{"version":"1.0.0","segments":[{"speaker":"John Simboli","startTime":0.0,"endTime":1.98,"body":"Welcome to"},{"speaker":"John Simboli","startTime":0.0,"endTime":1.98,"body":"BioBoss, Abbas,"},{"speaker":"Abbas Kazimi","startTime":1.98,"endTime":3.72,"body":"Thanks, John, it's"},{"speaker":"Abbas Kazimi","startTime":1.98,"endTime":3.72,"body":"great to be here."},{"speaker":"John Simboli","startTime":3.72,"endTime":6.96,"body":"Abbas, what led"},{"speaker":"John Simboli","startTime":3.72,"endTime":6.96,"body":"you to your role as CEO at"},{"speaker":"John Simboli","startTime":6.96,"endTime":8.16,"body":"Nimbus therapeutics?"},{"speaker":"Abbas Kazimi","startTime":8.24,"endTime":10.46,"body":"Honestly, John,"},{"speaker":"Abbas Kazimi","startTime":8.24,"endTime":10.46,"body":"it's been a journey, both by"},{"speaker":"Abbas Kazimi","startTime":10.46,"endTime":15.62,"body":"circumstance and purpose. You"},{"speaker":"Abbas Kazimi","startTime":10.46,"endTime":15.62,"body":"know, I joined Nimbus more than"},{"speaker":"Abbas Kazimi","startTime":15.62,"endTime":19.64,"body":"a decade ago after getting a"},{"speaker":"Abbas Kazimi","startTime":15.62,"endTime":19.64,"body":"call from our first Chief"},{"speaker":"Abbas Kazimi","startTime":19.64,"endTime":24.38,"body":"Business Officer in 2014 and it"},{"speaker":"Abbas Kazimi","startTime":19.64,"endTime":24.38,"body":"was a moment where he called and"},{"speaker":"Abbas Kazimi","startTime":24.38,"endTime":27.92,"body":"said, I'm looking for BD talent."},{"speaker":"Abbas Kazimi","startTime":24.38,"endTime":27.92,"body":"Do you know anyone good? And at"},{"speaker":"Abbas Kazimi","startTime":27.92,"endTime":32.165,"body":"that point, I said, Yeah, me."},{"speaker":"Abbas Kazimi","startTime":27.92,"endTime":32.165,"body":"And so that moment really opened"},{"speaker":"Abbas Kazimi","startTime":32.165,"endTime":34.685,"body":"a door, and I've been here ever"},{"speaker":"Abbas Kazimi","startTime":32.165,"endTime":34.685,"body":"since. I think it's rare in our"},{"speaker":"Abbas Kazimi","startTime":34.685,"endTime":39.365,"body":"industry, especially in biotech,"},{"speaker":"Abbas Kazimi","startTime":34.685,"endTime":39.365,"body":"to find people who've stuck"},{"speaker":"Abbas Kazimi","startTime":39.365,"endTime":43.445,"body":"around a mission that's gone"},{"speaker":"Abbas Kazimi","startTime":39.365,"endTime":43.445,"body":"through so many cycles in our"},{"speaker":"Abbas Kazimi","startTime":43.445,"endTime":46.985,"body":"industry, but cycles as a"},{"speaker":"Abbas Kazimi","startTime":43.445,"endTime":46.985,"body":"company. And that first time,"},{"speaker":"Abbas Kazimi","startTime":46.985,"endTime":49.685,"body":"actually, when, when I got that"},{"speaker":"Abbas Kazimi","startTime":46.985,"endTime":49.685,"body":"call, was also the first time I"},{"speaker":"Abbas Kazimi","startTime":49.685,"endTime":53.285,"body":"realized the simplicity of just"},{"speaker":"Abbas Kazimi","startTime":49.685,"endTime":53.285,"body":"asking, for yourself, and the"},{"speaker":"Abbas Kazimi","startTime":53.285,"endTime":55.67,"body":"confidence that can give you of"},{"speaker":"Abbas Kazimi","startTime":53.285,"endTime":55.67,"body":"saying, Well, if you're looking"},{"speaker":"Abbas Kazimi","startTime":55.67,"endTime":59.33,"body":"for talent, and perhaps it's my"},{"speaker":"Abbas Kazimi","startTime":55.67,"endTime":59.33,"body":"turn, to transition from the"},{"speaker":"Abbas Kazimi","startTime":59.33,"endTime":62.69,"body":"investor banking side of the"},{"speaker":"Abbas Kazimi","startTime":59.33,"endTime":62.69,"body":"industry to a more operational"},{"speaker":"Abbas Kazimi","startTime":62.69,"endTime":65.93,"body":"role. So since day one, I've"},{"speaker":"Abbas Kazimi","startTime":62.69,"endTime":65.93,"body":"just been drawn to the company's"},{"speaker":"Abbas Kazimi","startTime":65.93,"endTime":68.21,"body":"mission, you know, using deep"},{"speaker":"Abbas Kazimi","startTime":65.93,"endTime":68.21,"body":"science, cutting-edge"},{"speaker":"Abbas Kazimi","startTime":68.21,"endTime":71.03,"body":"computation to make these"},{"speaker":"Abbas Kazimi","startTime":68.21,"endTime":71.03,"body":"transformative medicines,John."},{"speaker":"Abbas Kazimi","startTime":71.03,"endTime":73.61,"body":"It started in business"},{"speaker":"Abbas Kazimi","startTime":71.03,"endTime":73.61,"body":"development, doing a lot of"},{"speaker":"Abbas Kazimi","startTime":73.61,"endTime":79.955,"body":"deals, from our sales of TYK2,"},{"speaker":"Abbas Kazimi","startTime":73.61,"endTime":79.955,"body":"our sale to Takeda, to our sale"},{"speaker":"Abbas Kazimi","startTime":79.955,"endTime":83.795,"body":"of our NASH product to Gilead,"},{"speaker":"Abbas Kazimi","startTime":79.955,"endTime":83.795,"body":"but, honestly, over time, I just"},{"speaker":"Abbas Kazimi","startTime":83.795,"endTime":87.995,"body":"became invested in the people,"},{"speaker":"Abbas Kazimi","startTime":83.795,"endTime":87.995,"body":"the platform, and I was doing"},{"speaker":"Abbas Kazimi","startTime":87.995,"endTime":90.935,"body":"the deals in the background,"},{"speaker":"Abbas Kazimi","startTime":87.995,"endTime":90.935,"body":"where it just became more"},{"speaker":"Abbas Kazimi","startTime":90.935,"endTime":94.415,"body":"natural. And so for me, it was a"},{"speaker":"Abbas Kazimi","startTime":90.935,"endTime":94.415,"body":"transition from doing deals and"},{"speaker":"Abbas Kazimi","startTime":95.015,"endTime":99.215,"body":"transacting to eventually"},{"speaker":"Abbas Kazimi","startTime":95.015,"endTime":99.215,"body":"building a company. So when our"},{"speaker":"Abbas Kazimi","startTime":99.215,"endTime":103.7,"body":"former CEO stepped aside after"},{"speaker":"Abbas Kazimi","startTime":99.215,"endTime":103.7,"body":"11 years—we were together for"},{"speaker":"Abbas Kazimi","startTime":103.7,"endTime":107.48,"body":"those 11 years—a deep"},{"speaker":"Abbas Kazimi","startTime":103.7,"endTime":107.48,"body":"relationship, and the board"},{"speaker":"Abbas Kazimi","startTime":107.48,"endTime":111.56,"body":"asked me to step in. I took on"},{"speaker":"Abbas Kazimi","startTime":107.48,"endTime":111.56,"body":"the role with this deep respect"},{"speaker":"Abbas Kazimi","startTime":111.56,"endTime":115.7,"body":"for the legacy Nimbus has built,"},{"speaker":"Abbas Kazimi","startTime":111.56,"endTime":115.7,"body":"and just a real responsibility"},{"speaker":"Abbas Kazimi","startTime":116.06,"endTime":119.78,"body":"to lead Nimbus into the next"},{"speaker":"Abbas Kazimi","startTime":116.06,"endTime":119.78,"body":"chapter. So I didn't just land"},{"speaker":"Abbas Kazimi","startTime":119.78,"endTime":123.845,"body":"in the role. I  look at this as"},{"speaker":"Abbas Kazimi","startTime":119.78,"endTime":123.845,"body":"I grew into the role the"},{"speaker":"Abbas Kazimi","startTime":123.845,"endTime":127.145,"body":"organization, for me till this"},{"speaker":"Abbas Kazimi","startTime":123.845,"endTime":127.145,"body":"day, it's just not defined by a"},{"speaker":"Abbas Kazimi","startTime":127.145,"endTime":131.405,"body":"single leader, a single"},{"speaker":"Abbas Kazimi","startTime":127.145,"endTime":131.405,"body":"modality, a single platform or a"},{"speaker":"Abbas Kazimi","startTime":131.405,"endTime":134.885,"body":"single investor, and it's much"},{"speaker":"Abbas Kazimi","startTime":131.405,"endTime":134.885,"body":"more than that. And for me, it's"},{"speaker":"Abbas Kazimi","startTime":134.885,"endTime":138.485,"body":"the ability to honor the legacy"},{"speaker":"Abbas Kazimi","startTime":134.885,"endTime":138.485,"body":"that we've built, because I"},{"speaker":"Abbas Kazimi","startTime":138.485,"endTime":141.365,"body":"believe in our science, our team"},{"speaker":"Abbas Kazimi","startTime":138.485,"endTime":141.365,"body":"and the ability to make this"},{"speaker":"Abbas Kazimi","startTime":141.425,"endTime":143.045,"body":"lasting impact in the industry."},{"speaker":"John Simboli","startTime":143.045,"endTime":146.81,"body":"A couple of year"},{"speaker":"John Simboli","startTime":143.045,"endTime":146.81,"body":"ago, I interviewed a leader, a"},{"speaker":"John Simboli","startTime":146.81,"endTime":150.59,"body":"CEO at a biopharma company, who"},{"speaker":"John Simboli","startTime":146.81,"endTime":150.59,"body":"had come to the job from Chief"},{"speaker":"John Simboli","startTime":150.59,"endTime":154.61,"body":"Business Officer. And in his"},{"speaker":"John Simboli","startTime":150.59,"endTime":154.61,"body":"case, he had recently joined the"},{"speaker":"John Simboli","startTime":154.61,"endTime":158.21,"body":"company, and he had been"},{"speaker":"John Simboli","startTime":154.61,"endTime":158.21,"body":"Business Officer at some other"},{"speaker":"John Simboli","startTime":158.21,"endTime":161.27,"body":"places. He was accustomed to ,as"},{"speaker":"John Simboli","startTime":158.21,"endTime":161.27,"body":"Chief Business Officer, coming"},{"speaker":"John Simboli","startTime":161.27,"endTime":164.69,"body":"to meetings with the C-suite"},{"speaker":"John Simboli","startTime":161.27,"endTime":164.69,"body":"team with a series of ideas, and"},{"speaker":"John Simboli","startTime":164.69,"endTime":167.93,"body":"saying, What do you think of"},{"speaker":"John Simboli","startTime":164.69,"endTime":167.93,"body":"this, this and this? And then he"},{"speaker":"John Simboli","startTime":167.93,"endTime":171.155,"body":"said, once he became CEO, almost"},{"speaker":"John Simboli","startTime":167.93,"endTime":171.155,"body":"by default, he did the same"},{"speaker":"John Simboli","startTime":171.155,"endTime":174.455,"body":"thing. And at the first meeting,"},{"speaker":"John Simboli","startTime":171.155,"endTime":174.455,"body":"he said there was a long quiet"},{"speaker":"John Simboli","startTime":174.455,"endTime":177.275,"body":"period, and people said, Yeah,"},{"speaker":"John Simboli","startTime":174.455,"endTime":177.275,"body":"but which one are we going to"},{"speaker":"John Simboli","startTime":177.275,"endTime":180.995,"body":"do? You know, your job is not to"},{"speaker":"John Simboli","startTime":177.275,"endTime":180.995,"body":"propose all these options. Your"},{"speaker":"John Simboli","startTime":180.995,"endTime":183.695,"body":"job is to help us choose which"},{"speaker":"John Simboli","startTime":180.995,"endTime":183.695,"body":"one. That's a real"},{"speaker":"John Simboli","startTime":183.695,"endTime":187.415,"body":"simplification. But did you"},{"speaker":"John Simboli","startTime":183.695,"endTime":187.415,"body":"experience anything like that?"},{"speaker":"Unknown","startTime":188.26,"endTime":191.26,"body":"I think what was unique"},{"speaker":"Unknown","startTime":188.26,"endTime":191.26,"body":"about Nimbus has been, you know,"},{"speaker":"Unknown","startTime":191.26,"endTime":196.12,"body":"I am, I would say, the fourth"},{"speaker":"Unknown","startTime":191.26,"endTime":196.12,"body":"CEO at Nimbus over 16 years that"},{"speaker":"Unknown","startTime":196.12,"endTime":199.84,"body":"we have been around. The first"},{"speaker":"Unknown","startTime":196.12,"endTime":199.84,"body":"one was, you know, Bruce Booth,"},{"speaker":"Unknown","startTime":199.9,"endTime":202.66,"body":"Atlas venture partner who"},{"speaker":"Unknown","startTime":199.9,"endTime":202.66,"body":"started Nimbus, and then"},{"speaker":"Unknown","startTime":202.66,"endTime":207.04,"body":"officially, we hired our first"},{"speaker":"Unknown","startTime":202.66,"endTime":207.04,"body":"CEO in 2014, when I started as"},{"speaker":"Unknown","startTime":207.04,"endTime":210.64,"body":"well, by an individual named Don"},{"speaker":"Unknown","startTime":207.04,"endTime":210.64,"body":"Nicholson. And Don came from an"},{"speaker":"Unknown","startTime":210.64,"endTime":214.045,"body":"experience from Merck.,"},{"speaker":"Unknown","startTime":210.64,"endTime":214.045,"body":"extraordinary career, really"},{"speaker":"Unknown","startTime":214.045,"endTime":218.305,"body":"successful, retired. We brought"},{"speaker":"Unknown","startTime":214.045,"endTime":218.305,"body":"him out of Merck to run Nimbus."},{"speaker":"Unknown","startTime":218.305,"endTime":225.145,"body":"So more of your PhD-science-CEO"},{"speaker":"Unknown","startTime":218.305,"endTime":225.145,"body":"type. Eventually, when Don,"},{"speaker":"Unknown","startTime":225.205,"endTime":229.465,"body":"after our phase one exit to"},{"speaker":"Unknown","startTime":225.205,"endTime":229.465,"body":"Gilead, he left to go back into"},{"speaker":"Unknown","startTime":229.465,"endTime":235.75,"body":"retirement around 2016-2017. Jeb"},{"speaker":"Unknown","startTime":229.465,"endTime":235.75,"body":"Keiper, our CBO, at that point,"},{"speaker":"Unknown","startTime":235.93,"endTime":239.89,"body":"took on the CEO role for the"},{"speaker":"Unknown","startTime":235.93,"endTime":239.89,"body":"next six, seven years until this"},{"speaker":"Unknown","startTime":239.89,"endTime":243.85,"body":"recent transition. So why I'm"},{"speaker":"Unknown","startTime":239.89,"endTime":243.85,"body":"giving that history perspective"},{"speaker":"Unknown","startTime":243.85,"endTime":249.07,"body":"here is because I think the way"},{"speaker":"Unknown","startTime":243.85,"endTime":249.07,"body":"we run the organization, it's"},{"speaker":"Unknown","startTime":249.07,"endTime":254.17,"body":"disseminated where even now, my"},{"speaker":"Unknown","startTime":249.07,"endTime":254.17,"body":"style is more about this. It's I"},{"speaker":"Unknown","startTime":254.17,"endTime":258.355,"body":"bring in the team to a very"},{"speaker":"Unknown","startTime":254.17,"endTime":258.355,"body":"depth perspective. We share BD"},{"speaker":"Unknown","startTime":258.355,"endTime":261.595,"body":"updates with our executive team."},{"speaker":"Unknown","startTime":258.355,"endTime":261.595,"body":"So head of biology, head of"},{"speaker":"Unknown","startTime":261.595,"endTime":265.435,"body":"chemistry, head of TOX. They're"},{"speaker":"Unknown","startTime":261.595,"endTime":265.435,"body":"fairly aware of the"},{"speaker":"Unknown","startTime":265.435,"endTime":267.955,"body":"conversations that were"},{"speaker":"Unknown","startTime":265.435,"endTime":267.955,"body":"happening, and that's just"},{"speaker":"Unknown","startTime":267.955,"endTime":271.795,"body":"because our business model."},{"speaker":"Unknown","startTime":267.955,"endTime":271.795,"body":"Eventually, Nimbus is a BD sort"},{"speaker":"Unknown","startTime":271.795,"endTime":275.635,"body":"of driven business model. In all"},{"speaker":"Unknown","startTime":271.795,"endTime":275.635,"body":"of our years, in 16 years, I"},{"speaker":"Unknown","startTime":275.635,"endTime":279.64,"body":"haven't really forecasted a"},{"speaker":"Unknown","startTime":275.635,"endTime":279.64,"body":"sales force to hire. I've"},{"speaker":"Unknown","startTime":279.64,"endTime":284.14,"body":"thought about how far we can"},{"speaker":"Unknown","startTime":279.64,"endTime":284.14,"body":"take a drug to build value, and"},{"speaker":"Unknown","startTime":284.14,"endTime":287.98,"body":"I think it's a culture we have"},{"speaker":"Unknown","startTime":284.14,"endTime":287.98,"body":"to cultivate. And that culture"},{"speaker":"Unknown","startTime":287.98,"endTime":292.06,"body":"has implications on how"},{"speaker":"Unknown","startTime":287.98,"endTime":292.06,"body":"leadership shows up. And what"},{"speaker":"Unknown","startTime":292.06,"endTime":295.48,"body":"I've learned from, you know,"},{"speaker":"Unknown","startTime":292.06,"endTime":295.48,"body":"mentors within Nimbus, outside"},{"speaker":"Unknown","startTime":295.48,"endTime":299.08,"body":"of Nimbus, is we disseminate"},{"speaker":"Unknown","startTime":295.48,"endTime":299.08,"body":"this leadership, and when it"},{"speaker":"Unknown","startTime":299.08,"endTime":301.06,"body":"comes down to the most"},{"speaker":"Unknown","startTime":299.08,"endTime":301.06,"body":"complicated part of our"},{"speaker":"Unknown","startTime":301.06,"endTime":304.525,"body":"industry, John, the question"},{"speaker":"Unknown","startTime":301.06,"endTime":304.525,"body":"around who makes decisions."},{"speaker":"Unknown","startTime":304.705,"endTime":308.725,"body":"That's an inevitable conundrum"},{"speaker":"Unknown","startTime":304.705,"endTime":308.725,"body":"every company will have every"},{"speaker":"Unknown","startTime":308.725,"endTime":312.505,"body":"year. I think for us right now,"},{"speaker":"Unknown","startTime":308.725,"endTime":312.505,"body":"it's always been the, well, the"},{"speaker":"Unknown","startTime":312.505,"endTime":316.645,"body":"BD person or the CBO brought"},{"speaker":"Unknown","startTime":312.505,"endTime":316.645,"body":"deals forward, now you're going"},{"speaker":"Unknown","startTime":316.645,"endTime":320.725,"body":"to decide. I think the decision"},{"speaker":"Unknown","startTime":316.645,"endTime":320.725,"body":"factor at the end of the day, we"},{"speaker":"Unknown","startTime":320.725,"endTime":325.105,"body":"all make a strong recommendation"},{"speaker":"Unknown","startTime":320.725,"endTime":325.105,"body":"together. Our board is a"},{"speaker":"Unknown","startTime":325.15,"endTime":329.41,"body":"spectacular board where it's"},{"speaker":"Unknown","startTime":325.15,"endTime":329.41,"body":"never felt in the past decade or"},{"speaker":"Unknown","startTime":329.41,"endTime":332.53,"body":"so, where they're telling us"},{"speaker":"Unknown","startTime":329.41,"endTime":332.53,"body":"what to do. So I'll go to them"},{"speaker":"Unknown","startTime":332.83,"endTime":337.63,"body":"for advice, as you should with a"},{"speaker":"Unknown","startTime":332.83,"endTime":337.63,"body":"recommendation, and once I feel"},{"speaker":"Unknown","startTime":337.63,"endTime":340.87,"body":"confident that I have all the"},{"speaker":"Unknown","startTime":337.63,"endTime":340.87,"body":"viewpoints from my team, from"},{"speaker":"Unknown","startTime":340.87,"endTime":345.31,"body":"our investors and our board, a"},{"speaker":"Unknown","startTime":340.87,"endTime":345.31,"body":"decision feels more natural and"},{"speaker":"Unknown","startTime":345.31,"endTime":349.03,"body":"more inclusive versus the"},{"speaker":"Unknown","startTime":345.31,"endTime":349.03,"body":"classic, I'm going to make a"},{"speaker":"Unknown","startTime":349.03,"endTime":351.235,"body":"hierarchical decision, and"},{"speaker":"Unknown","startTime":349.03,"endTime":351.235,"body":"you're all going to fall in"},{"speaker":"Unknown","startTime":351.235,"endTime":353.575,"body":"line. So we're reversing the"},{"speaker":"Unknown","startTime":351.235,"endTime":353.575,"body":"script here. We're reversing"},{"speaker":"Unknown","startTime":353.575,"endTime":357.295,"body":"where decisions naturally grow"},{"speaker":"Unknown","startTime":353.575,"endTime":357.295,"body":"versus decisions are actually"},{"speaker":"Unknown","startTime":357.295,"endTime":359.575,"body":"written down with the 10"},{"speaker":"Unknown","startTime":357.295,"endTime":359.575,"body":"Commandments, and you must"},{"speaker":"Unknown","startTime":359.575,"endTime":360.415,"body":"follow them."},{"speaker":"John Simboli","startTime":360.415,"endTime":362.695,"body":"It seems to me"},{"speaker":"John Simboli","startTime":360.415,"endTime":362.695,"body":"that, just reading a bit about"},{"speaker":"John Simboli","startTime":362.695,"endTime":367.195,"body":"your blog about potential for"},{"speaker":"John Simboli","startTime":362.695,"endTime":367.195,"body":"advancing through failing fast,"},{"speaker":"John Simboli","startTime":367.195,"endTime":371.275,"body":"I think, is the title of the"},{"speaker":"John Simboli","startTime":367.195,"endTime":371.275,"body":"work, and just how you're"},{"speaker":"John Simboli","startTime":371.275,"endTime":375.04,"body":"talking about Nimbus and what"},{"speaker":"John Simboli","startTime":371.275,"endTime":375.04,"body":"its background was, maybe you're"},{"speaker":"John Simboli","startTime":375.04,"endTime":380.62,"body":"more prepared to deal with that"},{"speaker":"John Simboli","startTime":375.04,"endTime":380.62,"body":"kind of uncertainty than some"},{"speaker":"John Simboli","startTime":380.62,"endTime":381.16,"body":"folks."},{"speaker":"Unknown","startTime":383.16,"endTime":387.18,"body":"I would say I'm pretty"},{"speaker":"Unknown","startTime":383.16,"endTime":387.18,"body":"self aware of what I am and what"},{"speaker":"Unknown","startTime":387.18,"endTime":390.66,"body":"I'm not. I think, you know, I'm"},{"speaker":"Unknown","startTime":387.18,"endTime":390.66,"body":"not a classically trained, you"},{"speaker":"Unknown","startTime":390.66,"endTime":394.8,"body":"know, MBA from a leadership"},{"speaker":"Unknown","startTime":390.66,"endTime":394.8,"body":"school of thought here. I'm more"},{"speaker":"Unknown","startTime":394.8,"endTime":400.14,"body":"of a curiosity-driven leader."},{"speaker":"Unknown","startTime":394.8,"endTime":400.14,"body":"I'm more of a believer in the"},{"speaker":"Unknown","startTime":400.14,"endTime":405.18,"body":"power of teams. So what I've"},{"speaker":"Unknown","startTime":400.14,"endTime":405.18,"body":"learned about myself, and"},{"speaker":"Unknown","startTime":405.18,"endTime":408.945,"body":"especially now in this past"},{"speaker":"Unknown","startTime":405.18,"endTime":408.945,"body":"transition and even the past"},{"speaker":"Unknown","startTime":408.945,"endTime":412.665,"body":"couple of years, I had a"},{"speaker":"Unknown","startTime":408.945,"endTime":412.665,"body":"fortunate position to be as a"},{"speaker":"Unknown","startTime":412.665,"endTime":416.085,"body":"CBO, part of the board"},{"speaker":"Unknown","startTime":412.665,"endTime":416.085,"body":"conversations, that leadership,"},{"speaker":"Unknown","startTime":416.085,"endTime":419.565,"body":"for me, has never really felt"},{"speaker":"Unknown","startTime":416.085,"endTime":419.565,"body":"about having the answers. It's"},{"speaker":"Unknown","startTime":419.565,"endTime":424.305,"body":"about having better questions,"},{"speaker":"Unknown","startTime":419.565,"endTime":424.305,"body":"creating the space for others to"},{"speaker":"Unknown","startTime":424.305,"endTime":430.05,"body":"lead. And so it is challenging,"},{"speaker":"Unknown","startTime":424.305,"endTime":430.05,"body":"especially when I had a partner"},{"speaker":"Unknown","startTime":430.05,"endTime":435.21,"body":"in crime for 11 years, where the"},{"speaker":"Unknown","startTime":430.05,"endTime":435.21,"body":"CEO and myself, at that time"},{"speaker":"Unknown","startTime":435.21,"endTime":439.95,"body":"would candidly tell each other"},{"speaker":"Unknown","startTime":435.21,"endTime":439.95,"body":"we're fairly comfortable with"},{"speaker":"Unknown","startTime":440.85,"endTime":444.21,"body":"70-75% information and taking a"},{"speaker":"Unknown","startTime":440.85,"endTime":444.21,"body":"risk. And I think that is how"},{"speaker":"Unknown","startTime":444.21,"endTime":448.65,"body":"biotechs move fast, but also we"},{"speaker":"Unknown","startTime":444.21,"endTime":448.65,"body":"can move fast with confidence."},{"speaker":"Unknown","startTime":448.65,"endTime":454.095,"body":"And you know, we know that we're"},{"speaker":"Unknown","startTime":448.65,"endTime":454.095,"body":"managing and fortunate to work"},{"speaker":"Unknown","startTime":454.095,"endTime":459.735,"body":"with incredible scientists who"},{"speaker":"Unknown","startTime":454.095,"endTime":459.735,"body":"need to see all the data to take"},{"speaker":"Unknown","startTime":459.735,"endTime":463.215,"body":"that risk on the next step. I"},{"speaker":"Unknown","startTime":459.735,"endTime":463.215,"body":"think where leadership comes in"},{"speaker":"Unknown","startTime":463.215,"endTime":465.855,"body":"is the ability to convey"},{"speaker":"Unknown","startTime":463.215,"endTime":465.855,"body":"confidence that even if we were"},{"speaker":"Unknown","startTime":465.855,"endTime":469.215,"body":"taking this risk, even if we're"},{"speaker":"Unknown","startTime":465.855,"endTime":469.215,"body":"going to kill this program, as"},{"speaker":"Unknown","startTime":469.215,"endTime":473.355,"body":"you mentioned in that blog we"},{"speaker":"Unknown","startTime":469.215,"endTime":473.355,"body":"wrote, there's net benefit,"},{"speaker":"Unknown","startTime":473.355,"endTime":476.76,"body":"because ultimately, we're driven"},{"speaker":"Unknown","startTime":473.355,"endTime":476.76,"body":"by the same collective, and that"},{"speaker":"Unknown","startTime":476.76,"endTime":479.82,"body":"same collective is our purpose,"},{"speaker":"Unknown","startTime":476.76,"endTime":479.82,"body":"and our purpose is to serve"},{"speaker":"Unknown","startTime":480.0,"endTime":484.02,"body":"patients. And so I think when I"},{"speaker":"Unknown","startTime":480.0,"endTime":484.02,"body":"began my career in the industry,"},{"speaker":"Unknown","startTime":484.38,"endTime":487.74,"body":"I always found it humorous, I"},{"speaker":"Unknown","startTime":484.38,"endTime":487.74,"body":"found it's, you know, really"},{"speaker":"Unknown","startTime":487.8,"endTime":490.38,"body":"rudimentary to, Why do they"},{"speaker":"Unknown","startTime":487.8,"endTime":490.38,"body":"always keep mentioning the"},{"speaker":"Unknown","startTime":490.38,"endTime":493.14,"body":"mission? Why is it always"},{"speaker":"Unknown","startTime":490.38,"endTime":493.14,"body":"everyone opens in the meeting?"},{"speaker":"Unknown","startTime":493.14,"endTime":497.22,"body":"And over the years, I realized"},{"speaker":"Unknown","startTime":493.14,"endTime":497.22,"body":"that it's so powerful because it"},{"speaker":"Unknown","startTime":497.22,"endTime":500.325,"body":"actually is what kept me"},{"speaker":"Unknown","startTime":497.22,"endTime":500.325,"body":"grounded. It keeps me grounded"},{"speaker":"Unknown","startTime":500.625,"endTime":504.165,"body":"even now to the team. And so to"},{"speaker":"Unknown","startTime":500.625,"endTime":504.165,"body":"answer your question more"},{"speaker":"Unknown","startTime":504.165,"endTime":509.025,"body":"clearly, it's first, there's"},{"speaker":"Unknown","startTime":504.165,"endTime":509.025,"body":"comfort in taking risk with"},{"speaker":"Unknown","startTime":509.025,"endTime":511.545,"body":"knowing very little if you"},{"speaker":"Unknown","startTime":509.025,"endTime":511.545,"body":"believe in the value of the"},{"speaker":"Unknown","startTime":511.545,"endTime":516.885,"body":"individuals around you. Two, I"},{"speaker":"Unknown","startTime":511.545,"endTime":516.885,"body":"think gratitude is the backbone"},{"speaker":"Unknown","startTime":516.885,"endTime":520.005,"body":"of how I lead. It keeps me"},{"speaker":"Unknown","startTime":516.885,"endTime":520.005,"body":"grounded, especially when the"},{"speaker":"Unknown","startTime":520.05,"endTime":523.41,"body":"stakes are high, and so the"},{"speaker":"Unknown","startTime":520.05,"endTime":523.41,"body":"gratitude comes in that we're"},{"speaker":"Unknown","startTime":523.41,"endTime":526.47,"body":"very fortunate in this where"},{"speaker":"Unknown","startTime":523.41,"endTime":526.47,"body":"we've developed a business model"},{"speaker":"Unknown","startTime":526.83,"endTime":531.39,"body":"that allows us to take risk, and"},{"speaker":"Unknown","startTime":526.83,"endTime":531.39,"body":"if there's failure, we actually"},{"speaker":"Unknown","startTime":531.39,"endTime":533.73,"body":"celebrate that failure, because"},{"speaker":"Unknown","startTime":531.39,"endTime":533.73,"body":"we know there's more"},{"speaker":"Unknown","startTime":533.73,"endTime":537.63,"body":"opportunities that we can go"},{"speaker":"Unknown","startTime":533.73,"endTime":537.63,"body":"back to, to continue serving our"},{"speaker":"Unknown","startTime":537.63,"endTime":541.11,"body":"mission. Our mission isn't to"},{"speaker":"Unknown","startTime":537.63,"endTime":541.11,"body":"serve a single individual with a"},{"speaker":"Unknown","startTime":541.11,"endTime":545.175,"body":"single disease. It's to impact,"},{"speaker":"Unknown","startTime":541.11,"endTime":545.175,"body":"broadly, patients. And so I just"},{"speaker":"Unknown","startTime":545.175,"endTime":548.055,"body":"try to keep myself grounded in"},{"speaker":"Unknown","startTime":545.175,"endTime":548.055,"body":"that gratitude perspective and"},{"speaker":"Unknown","startTime":548.055,"endTime":551.355,"body":"the perspective of, why are we"},{"speaker":"Unknown","startTime":548.055,"endTime":551.355,"body":"here together, and that allows"},{"speaker":"Unknown","startTime":551.355,"endTime":554.535,"body":"us to take risks together. And"},{"speaker":"Unknown","startTime":551.355,"endTime":554.535,"body":"so I think that is a very unique"},{"speaker":"Unknown","startTime":554.535,"endTime":558.195,"body":"culture that we built. And"},{"speaker":"Unknown","startTime":554.535,"endTime":558.195,"body":"again, I'll credit that to being"},{"speaker":"Unknown","startTime":558.195,"endTime":561.435,"body":"around for this many years, but"},{"speaker":"Unknown","startTime":558.195,"endTime":561.435,"body":"also the company going through a"},{"speaker":"Unknown","startTime":561.435,"endTime":565.635,"body":"lot of changes in 16 years,"},{"speaker":"Unknown","startTime":561.435,"endTime":565.635,"body":"allows you to keep redefining"},{"speaker":"Unknown","startTime":565.635,"endTime":568.8,"body":"yourself, but you decide at what"},{"speaker":"Unknown","startTime":565.635,"endTime":568.8,"body":"point what kind of holds you"},{"speaker":"Unknown","startTime":568.8,"endTime":572.34,"body":"together. And I think those two"},{"speaker":"Unknown","startTime":568.8,"endTime":572.34,"body":"aspects of gratitude and mission"},{"speaker":"Unknown","startTime":572.64,"endTime":575.28,"body":"really have allowed us to take"},{"speaker":"Unknown","startTime":572.64,"endTime":575.28,"body":"these risks together."},{"speaker":"John Simboli","startTime":575.96,"endTime":578.18,"body":"Your decision"},{"speaker":"John Simboli","startTime":575.96,"endTime":578.18,"body":"making process sounds like it's"},{"speaker":"John Simboli","startTime":578.18,"endTime":581.42,"body":"collegial. Sounds like it's"},{"speaker":"John Simboli","startTime":578.18,"endTime":581.42,"body":"based on a lot of interaction."},{"speaker":"John Simboli","startTime":582.2,"endTime":585.14,"body":"Now that you're CEO, as opposed"},{"speaker":"John Simboli","startTime":582.2,"endTime":585.14,"body":"to business officer, is that"},{"speaker":"John Simboli","startTime":585.14,"endTime":588.8,"body":"process of communicating it and"},{"speaker":"John Simboli","startTime":585.14,"endTime":588.8,"body":"bringing people on board any"},{"speaker":"John Simboli","startTime":588.8,"endTime":590.3,"body":"different than the way it was"},{"speaker":"John Simboli","startTime":588.8,"endTime":590.3,"body":"before?"},{"speaker":"Unknown","startTime":590.9,"endTime":594.08,"body":"The title is a service"},{"speaker":"Unknown","startTime":590.9,"endTime":594.08,"body":"role, so you define how you're"},{"speaker":"Unknown","startTime":594.08,"endTime":598.58,"body":"going to be in servitude. So"},{"speaker":"Unknown","startTime":594.08,"endTime":598.58,"body":"I've learned the best leadership"},{"speaker":"Unknown","startTime":598.58,"endTime":601.1,"body":"isn't about control at that"},{"speaker":"Unknown","startTime":598.58,"endTime":601.1,"body":"point, John. I think a lot of"},{"speaker":"Unknown","startTime":601.1,"endTime":604.16,"body":"people like to convey control,"},{"speaker":"Unknown","startTime":601.1,"endTime":604.16,"body":"and it's easy. And I've met,"},{"speaker":"Unknown","startTime":604.58,"endTime":608.72,"body":"myself, a full spectrum of CEOs"},{"speaker":"Unknown","startTime":604.58,"endTime":608.72,"body":"who are probably really well"},{"speaker":"Unknown","startTime":608.72,"endTime":612.86,"body":"known in the public sector, and"},{"speaker":"Unknown","startTime":608.72,"endTime":612.86,"body":"if you kind of talk to their"},{"speaker":"Unknown","startTime":612.86,"endTime":616.445,"body":"brain trust, they said, he knows"},{"speaker":"Unknown","startTime":612.86,"endTime":616.445,"body":"all the answers, or she knows"},{"speaker":"Unknown","startTime":616.625,"endTime":620.105,"body":"how to make all the decisions. I"},{"speaker":"Unknown","startTime":616.625,"endTime":620.105,"body":"would say, to your question,"},{"speaker":"Unknown","startTime":620.105,"endTime":625.985,"body":"what has changed? It's the role"},{"speaker":"Unknown","startTime":620.105,"endTime":625.985,"body":"has changed, and for me, it's"},{"speaker":"Unknown","startTime":625.985,"endTime":630.485,"body":"still less about control. What"},{"speaker":"Unknown","startTime":625.985,"endTime":630.485,"body":"I've tried to amplify further is"},{"speaker":"Unknown","startTime":630.485,"endTime":635.705,"body":"clarity, trust and presence. I"},{"speaker":"Unknown","startTime":630.485,"endTime":635.705,"body":"think those three, you know,"},{"speaker":"Unknown","startTime":636.05,"endTime":639.71,"body":"stools are so critical to"},{"speaker":"Unknown","startTime":636.05,"endTime":639.71,"body":"holding up a foundation that,"},{"speaker":"Unknown","startTime":639.71,"endTime":641.87,"body":"you know, early in my career, I"},{"speaker":"Unknown","startTime":639.71,"endTime":641.87,"body":"thought I had to have all the"},{"speaker":"Unknown","startTime":641.87,"endTime":645.47,"body":"answers. Now I know it's way"},{"speaker":"Unknown","startTime":641.87,"endTime":645.47,"body":"more powerful, again, to ask the"},{"speaker":"Unknown","startTime":645.47,"endTime":648.17,"body":"right questions, create that"},{"speaker":"Unknown","startTime":645.47,"endTime":648.17,"body":"space for others, to bring their"},{"speaker":"Unknown","startTime":648.17,"endTime":652.49,"body":"best. And if we're doing that, I"},{"speaker":"Unknown","startTime":648.17,"endTime":652.49,"body":"really believe reciprocity and"},{"speaker":"Unknown","startTime":652.67,"endTime":654.77,"body":"understanding—okay. Well,"},{"speaker":"Unknown","startTime":652.67,"endTime":654.77,"body":"actually, I do believe him—and I"},{"speaker":"Unknown","startTime":654.77,"endTime":658.19,"body":"do have trust in him, and I do"},{"speaker":"Unknown","startTime":654.77,"endTime":658.19,"body":"understand this clarity. And so"},{"speaker":"Unknown","startTime":658.79,"endTime":661.955,"body":"we will go back every year."},{"speaker":"Unknown","startTime":658.79,"endTime":661.955,"body":"Nimbus is fortunate, we take the"},{"speaker":"Unknown","startTime":661.955,"endTime":664.715,"body":"whole company off-site, and"},{"speaker":"Unknown","startTime":661.955,"endTime":664.715,"body":"inevitably, one of the"},{"speaker":"Unknown","startTime":664.715,"endTime":668.015,"body":"conversations for all these"},{"speaker":"Unknown","startTime":664.715,"endTime":668.015,"body":"years has gone back to the"},{"speaker":"Unknown","startTime":668.015,"endTime":671.615,"body":"fundamental of, how do we make a"},{"speaker":"Unknown","startTime":668.015,"endTime":671.615,"body":"decision, right? How does this"},{"speaker":"Unknown","startTime":671.615,"endTime":675.875,"body":"come down? And I think right"},{"speaker":"Unknown","startTime":671.615,"endTime":675.875,"body":"now, because I have been such a"},{"speaker":"Unknown","startTime":675.875,"endTime":678.875,"body":"presence at the company for"},{"speaker":"Unknown","startTime":675.875,"endTime":678.875,"body":"these years, they already know"},{"speaker":"Unknown","startTime":678.875,"endTime":681.155,"body":"me. They already know a little"},{"speaker":"Unknown","startTime":678.875,"endTime":681.155,"body":"bit of my style, I think what"},{"speaker":"Unknown","startTime":681.155,"endTime":683.72,"body":"they're trying to figure out is,"},{"speaker":"Unknown","startTime":681.155,"endTime":683.72,"body":"how much is that going to"},{"speaker":"Unknown","startTime":683.72,"endTime":686.9,"body":"change? And I think what they're"},{"speaker":"Unknown","startTime":683.72,"endTime":686.9,"body":"realizing, the change is now"},{"speaker":"Unknown","startTime":686.9,"endTime":691.04,"body":"further enhancement of clarity,"},{"speaker":"Unknown","startTime":686.9,"endTime":691.04,"body":"further enhancement of trust and"},{"speaker":"Unknown","startTime":691.04,"endTime":692.0,"body":"further enhancement of presence."},{"speaker":"John Simboli","startTime":692.12,"endTime":695.36,"body":"Do you think that"},{"speaker":"John Simboli","startTime":692.12,"endTime":695.36,"body":"those are characteristics that"},{"speaker":"John Simboli","startTime":695.36,"endTime":699.86,"body":"you came to the the world with,"},{"speaker":"John Simboli","startTime":695.36,"endTime":699.86,"body":"or do you think those are things"},{"speaker":"John Simboli","startTime":699.86,"endTime":700.52,"body":"that you learned?"},{"speaker":"Unknown","startTime":700.78,"endTime":704.315,"body":"It's probably nurture."},{"speaker":"Unknown","startTime":700.78,"endTime":704.315,"body":"You know, I grew up in a family"},{"speaker":"Unknown","startTime":704.38,"endTime":708.505,"body":"that worked extremely hard. Son"},{"speaker":"Unknown","startTime":704.38,"endTime":708.505,"body":"of immigrants, my siblings, you"},{"speaker":"Unknown","startTime":708.571,"endTime":712.237,"body":"know, both very successful in"},{"speaker":"Unknown","startTime":708.571,"endTime":712.237,"body":"their own right. You know,"},{"speaker":"Unknown","startTime":712.303,"endTime":715.773,"body":"one's, you know, a child"},{"speaker":"Unknown","startTime":712.303,"endTime":715.773,"body":"psychiatrist at the hospital"},{"speaker":"Unknown","startTime":715.838,"endTime":719.505,"body":"system down in Houston, a"},{"speaker":"Unknown","startTime":715.838,"endTime":719.505,"body":"brother who's been at McKinsey"},{"speaker":"Unknown","startTime":719.57,"endTime":723.498,"body":"for over 20 years, advising a"},{"speaker":"Unknown","startTime":719.57,"endTime":723.498,"body":"number of companies in private"},{"speaker":"Unknown","startTime":723.564,"endTime":727.23,"body":"equity, oil and gas, and I in"},{"speaker":"Unknown","startTime":723.564,"endTime":727.23,"body":"the biotech sector. And we"},{"speaker":"Unknown","startTime":727.296,"endTime":731.093,"body":"always kind of go back and"},{"speaker":"Unknown","startTime":727.296,"endTime":731.093,"body":"remind ourselves, from a humble"},{"speaker":"Unknown","startTime":731.159,"endTime":734.956,"body":"beginning of our parents did"},{"speaker":"Unknown","startTime":731.159,"endTime":734.956,"body":"something that's probably, in"},{"speaker":"Unknown","startTime":735.021,"endTime":739.015,"body":"our mind, more difficult than"},{"speaker":"Unknown","startTime":735.021,"endTime":739.015,"body":"starting a company or running a"},{"speaker":"Unknown","startTime":739.081,"endTime":743.074,"body":"company. To leave a culture, to"},{"speaker":"Unknown","startTime":739.081,"endTime":743.074,"body":"leave family, essentially, to"},{"speaker":"Unknown","startTime":743.14,"endTime":746.806,"body":"leave memories with your"},{"speaker":"Unknown","startTime":743.14,"endTime":746.806,"body":"siblings, to take on a risk, to"},{"speaker":"Unknown","startTime":746.872,"endTime":751.062,"body":"take on a risk that comes with a"},{"speaker":"Unknown","startTime":746.872,"endTime":751.062,"body":"lot of sacrifice, to go through"},{"speaker":"Unknown","startTime":751.128,"endTime":754.532,"body":"periods of humiliation, to go"},{"speaker":"Unknown","startTime":751.128,"endTime":754.532,"body":"through periods of not"},{"speaker":"Unknown","startTime":754.598,"endTime":758.657,"body":"understanding what it takes to"},{"speaker":"Unknown","startTime":754.598,"endTime":758.657,"body":"succeed. Because sometimes it's"},{"speaker":"Unknown","startTime":758.722,"endTime":762.913,"body":"not just about putting your head"},{"speaker":"Unknown","startTime":758.722,"endTime":762.913,"body":"down and getting good grades or"},{"speaker":"Unknown","startTime":762.978,"endTime":766.775,"body":"doing the best job. There's"},{"speaker":"Unknown","startTime":762.978,"endTime":766.775,"body":"other attributes. So that, for"},{"speaker":"Unknown","startTime":766.841,"endTime":770.704,"body":"me, is foundational, right? At"},{"speaker":"Unknown","startTime":766.841,"endTime":770.704,"body":"the end of the day, the sole"},{"speaker":"Unknown","startTime":770.769,"endTime":774.698,"body":"message my parents had was we"},{"speaker":"Unknown","startTime":770.769,"endTime":774.698,"body":"had each other. And we had the"},{"speaker":"Unknown","startTime":774.763,"endTime":778.953,"body":"sense that education and service"},{"speaker":"Unknown","startTime":774.763,"endTime":778.953,"body":"mattered, and we were a classic"},{"speaker":"Unknown","startTime":779.019,"endTime":783.274,"body":"family, where every night we had"},{"speaker":"Unknown","startTime":779.019,"endTime":783.274,"body":"dinner together, no matter what."},{"speaker":"Unknown","startTime":783.34,"endTime":787.137,"body":"When dad came home, we all"},{"speaker":"Unknown","startTime":783.34,"endTime":787.137,"body":"waited, and even till this day,"},{"speaker":"Unknown","startTime":787.203,"endTime":791.131,"body":"my wife and I, who's also in the"},{"speaker":"Unknown","startTime":787.203,"endTime":791.131,"body":"pharma industry, we tend to"},{"speaker":"Unknown","startTime":791.196,"endTime":794.208,"body":"create that culture of"},{"speaker":"Unknown","startTime":791.196,"endTime":794.208,"body":"conversation. And those"},{"speaker":"Unknown","startTime":794.274,"endTime":798.202,"body":"conversations, at the end of the"},{"speaker":"Unknown","startTime":794.274,"endTime":798.202,"body":"day, they get summarized by"},{"speaker":"Unknown","startTime":798.267,"endTime":802.065,"body":"doing something bigger than"},{"speaker":"Unknown","startTime":798.267,"endTime":802.065,"body":"yourself. And so I think about"},{"speaker":"Unknown","startTime":802.13,"endTime":805.666,"body":"memories a lot, and I think"},{"speaker":"Unknown","startTime":802.13,"endTime":805.666,"body":"about the immigrants and I"},{"speaker":"Unknown","startTime":805.731,"endTime":809.725,"body":"asked, you know, even someone"},{"speaker":"Unknown","startTime":805.731,"endTime":809.725,"body":"who lost a sibling. I said, you"},{"speaker":"Unknown","startTime":809.791,"endTime":813.784,"body":"know, what memories do you hold"},{"speaker":"Unknown","startTime":809.791,"endTime":813.784,"body":"on to your sibling who's much"},{"speaker":"Unknown","startTime":813.85,"endTime":817.516,"body":"older? And they said, listen,"},{"speaker":"Unknown","startTime":813.85,"endTime":817.516,"body":"when we left our family at"},{"speaker":"Unknown","startTime":817.582,"endTime":821.641,"body":"18-19, years old, we left the"},{"speaker":"Unknown","startTime":817.582,"endTime":821.641,"body":"formation of those memories. The"},{"speaker":"Unknown","startTime":821.706,"endTime":825.635,"body":"memories started becoming the"},{"speaker":"Unknown","startTime":821.706,"endTime":825.635,"body":"interactions we had, not the I"},{"speaker":"Unknown","startTime":825.7,"endTime":829.76,"body":"was there for your graduation, I"},{"speaker":"Unknown","startTime":825.7,"endTime":829.76,"body":"was there for your wedding, I"},{"speaker":"Unknown","startTime":829.825,"endTime":833.491,"body":"was there for your first child."},{"speaker":"Unknown","startTime":829.825,"endTime":833.491,"body":"And so that weight, it's"},{"speaker":"Unknown","startTime":833.557,"endTime":837.223,"body":"actually positive, it's"},{"speaker":"Unknown","startTime":833.557,"endTime":837.223,"body":"uplifting, and I bring that into"},{"speaker":"Unknown","startTime":837.289,"endTime":841.086,"body":"what I do at work every day,"},{"speaker":"Unknown","startTime":837.289,"endTime":841.086,"body":"because it now goes on to two"},{"speaker":"Unknown","startTime":841.152,"endTime":845.015,"body":"levels of personal attributes."},{"speaker":"Unknown","startTime":841.152,"endTime":845.015,"body":"Number one, illness has been"},{"speaker":"Unknown","startTime":845.08,"endTime":848.812,"body":"prevalent in my own family,"},{"speaker":"Unknown","startTime":845.08,"endTime":848.812,"body":"watching members of my family"},{"speaker":"Unknown","startTime":848.877,"endTime":853.068,"body":"get sick. I've lost my father to"},{"speaker":"Unknown","startTime":848.877,"endTime":853.068,"body":"AML. He had MDS, originally. My"},{"speaker":"Unknown","startTime":853.133,"endTime":857.258,"body":"mother has had a long diagnosis,"},{"speaker":"Unknown","startTime":853.133,"endTime":857.258,"body":"which I talk about very openly"},{"speaker":"Unknown","startTime":857.323,"endTime":861.579,"body":"with my teams here, because when"},{"speaker":"Unknown","startTime":857.323,"endTime":861.579,"body":"I get a call about, hey, we have"},{"speaker":"Unknown","startTime":861.644,"endTime":865.704,"body":"a new patient enrolled in our"},{"speaker":"Unknown","startTime":861.644,"endTime":865.704,"body":"trial, I know what it feels like"},{"speaker":"Unknown","startTime":865.769,"endTime":869.698,"body":"to be a family, to say, Okay,"},{"speaker":"Unknown","startTime":865.769,"endTime":869.698,"body":"we're going to take a risk and"},{"speaker":"Unknown","startTime":869.763,"endTime":873.822,"body":"join. So to bring that humility"},{"speaker":"Unknown","startTime":869.763,"endTime":873.822,"body":"and gratitude to the table, it"},{"speaker":"Unknown","startTime":873.888,"endTime":878.012,"body":"helps you clarify. It helps you"},{"speaker":"Unknown","startTime":873.888,"endTime":878.012,"body":"manage the pressure. And on the"},{"speaker":"Unknown","startTime":878.078,"endTime":881.679,"body":"other side, if you work in"},{"speaker":"Unknown","startTime":878.078,"endTime":881.679,"body":"gratitude of wow, we made it"},{"speaker":"Unknown","startTime":881.744,"endTime":885.607,"body":"here because of the sacrifice"},{"speaker":"Unknown","startTime":881.744,"endTime":885.607,"body":"someone took for us, it makes"},{"speaker":"Unknown","startTime":885.673,"endTime":889.536,"body":"all the other pressures less"},{"speaker":"Unknown","startTime":885.673,"endTime":889.536,"body":"about you and your ego proving"},{"speaker":"Unknown","startTime":889.601,"endTime":893.137,"body":"yourself and more about the"},{"speaker":"Unknown","startTime":889.601,"endTime":893.137,"body":"individuals around you and"},{"speaker":"Unknown","startTime":893.202,"endTime":897.065,"body":"saying, I want everyone to hear"},{"speaker":"Unknown","startTime":893.202,"endTime":897.065,"body":"and feel what success looks"},{"speaker":"Unknown","startTime":897.13,"endTime":900.928,"body":"like. When we signed one of our"},{"speaker":"Unknown","startTime":897.13,"endTime":900.928,"body":"first transactions, I just"},{"speaker":"Unknown","startTime":900.993,"endTime":905.118,"body":"couldn't wait to be with a team."},{"speaker":"Unknown","startTime":900.993,"endTime":905.118,"body":"Because for so long, we talked"},{"speaker":"Unknown","startTime":905.183,"endTime":909.308,"body":"about how we're trying to find"},{"speaker":"Unknown","startTime":905.183,"endTime":909.308,"body":"the right shepherd for our drug,"},{"speaker":"Unknown","startTime":909.374,"endTime":913.498,"body":"not the term sheet. And I think"},{"speaker":"Unknown","startTime":909.374,"endTime":913.498,"body":"that inevitably felt right when"},{"speaker":"Unknown","startTime":913.564,"endTime":917.82,"body":"we realized that wow, Gilead can"},{"speaker":"Unknown","startTime":913.564,"endTime":917.82,"body":"take our ACC drug and impact the"},{"speaker":"Unknown","startTime":917.885,"endTime":921.944,"body":"most patients with NASH. Wow."},{"speaker":"Unknown","startTime":917.885,"endTime":921.944,"body":"Christophe Weber from Takeda has"},{"speaker":"Unknown","startTime":922.01,"endTime":925.873,"body":"a bigger vision for TYK2 drug"},{"speaker":"Unknown","startTime":922.01,"endTime":925.873,"body":"than we ever had, right? He's"},{"speaker":"Unknown","startTime":925.938,"endTime":930.194,"body":"thinking globally. He's thinking"},{"speaker":"Unknown","startTime":925.938,"endTime":930.194,"body":"about 11 indications. We thought"},{"speaker":"Unknown","startTime":930.259,"endTime":934.253,"body":"about two. And if you find that"},{"speaker":"Unknown","startTime":930.259,"endTime":934.253,"body":"balance in life where you are"},{"speaker":"Unknown","startTime":934.318,"endTime":938.247,"body":"completely in service of the"},{"speaker":"Unknown","startTime":934.318,"endTime":938.247,"body":"molecules and the patients, and"},{"speaker":"Unknown","startTime":938.312,"endTime":942.503,"body":"I go back to how I was educated,"},{"speaker":"Unknown","startTime":938.312,"endTime":942.503,"body":"by watching family, by watching"},{"speaker":"Unknown","startTime":942.568,"endTime":946.431,"body":"parents, by watching other"},{"speaker":"Unknown","startTime":942.568,"endTime":946.431,"body":"immigrants grow through it John,"},{"speaker":"Unknown","startTime":946.496,"endTime":950.556,"body":"it feels more natural to me. It"},{"speaker":"Unknown","startTime":946.496,"endTime":950.556,"body":"feels more, an ability to make"},{"speaker":"Unknown","startTime":950.621,"endTime":953.829,"body":"more connections with"},{"speaker":"Unknown","startTime":950.621,"endTime":953.829,"body":"individuals at the company,"},{"speaker":"Unknown","startTime":953.895,"endTime":957.627,"body":"because now they get to see"},{"speaker":"Unknown","startTime":953.895,"endTime":957.627,"body":"someone who's not looking out"},{"speaker":"Unknown","startTime":957.692,"endTime":960.115,"body":"for his deal sheet or his own resume."},{"speaker":"John Simboli","startTime":960.715,"endTime":964.315,"body":"Along the way, do"},{"speaker":"John Simboli","startTime":960.715,"endTime":964.315,"body":"you recall picturing yourself in"},{"speaker":"John Simboli","startTime":964.315,"endTime":968.695,"body":"any particular role other than,"},{"speaker":"John Simboli","startTime":964.315,"endTime":968.695,"body":"I'll find that out; I'm curious?"},{"speaker":"Unknown","startTime":968.66,"endTime":970.28,"body":"You know, I would"},{"speaker":"Unknown","startTime":968.66,"endTime":970.28,"body":"probably say it's the last"},{"speaker":"Unknown","startTime":970.28,"endTime":974.54,"body":"piece, curiosity. And it's so"},{"speaker":"Unknown","startTime":970.28,"endTime":974.54,"body":"fascinating that you're"},{"speaker":"Unknown","startTime":974.72,"endTime":978.86,"body":"reflecting on a question that I"},{"speaker":"Unknown","startTime":974.72,"endTime":978.86,"body":"still think about till this day."},{"speaker":"Unknown","startTime":980.12,"endTime":983.84,"body":"You know, I was fortunate, in"},{"speaker":"Unknown","startTime":980.12,"endTime":983.84,"body":"undergrad, when you're in Texas"},{"speaker":"Unknown","startTime":983.84,"endTime":988.52,"body":"and you're a certain percent of"},{"speaker":"Unknown","startTime":983.84,"endTime":988.52,"body":"your graduating class, you're"},{"speaker":"Unknown","startTime":988.52,"endTime":991.025,"body":"guaranteed admission into the"},{"speaker":"Unknown","startTime":988.52,"endTime":991.025,"body":"University of Texas System. So I"},{"speaker":"Unknown","startTime":991.025,"endTime":993.725,"body":"went to UT, Austin, and then I"},{"speaker":"Unknown","startTime":991.025,"endTime":993.725,"body":"applied, I got into the business"},{"speaker":"Unknown","startTime":993.725,"endTime":996.845,"body":"school, and McCombs Business"},{"speaker":"Unknown","startTime":993.725,"endTime":996.845,"body":"School, phenomenal school,"},{"speaker":"Unknown","startTime":996.845,"endTime":1000.625,"body":"highly ranked and a coveted"},{"speaker":"Unknown","startTime":996.845,"endTime":1000.625,"body":"role. After the first year John,"},{"speaker":"Unknown","startTime":1000.625,"endTime":1005.185,"body":"I was like, What is this? Right?"},{"speaker":"Unknown","startTime":1000.625,"endTime":1005.185,"body":"There's a lot of soft skills"},{"speaker":"Unknown","startTime":1005.185,"endTime":1007.525,"body":"here that they're not teaching,"},{"speaker":"Unknown","startTime":1005.185,"endTime":1007.525,"body":"and they're teaching a lot of"},{"speaker":"Unknown","startTime":1007.525,"endTime":1010.825,"body":"fundamentals here that I'm not"},{"speaker":"Unknown","startTime":1007.525,"endTime":1010.825,"body":"really sure sparked my"},{"speaker":"Unknown","startTime":1010.825,"endTime":1016.39,"body":"curiosity. So I began my jumping"},{"speaker":"Unknown","startTime":1010.825,"endTime":1016.39,"body":"around within the university"},{"speaker":"Unknown","startTime":1016.39,"endTime":1019.15,"body":"that offered so much. And at one"},{"speaker":"Unknown","startTime":1016.39,"endTime":1019.15,"body":"point, I think I told myself"},{"speaker":"Unknown","startTime":1019.15,"endTime":1022.03,"body":"that you're never going to be"},{"speaker":"Unknown","startTime":1019.15,"endTime":1022.03,"body":"here again. This is a once in a"},{"speaker":"Unknown","startTime":1022.03,"endTime":1026.23,"body":"lifetime opportunity at such an"},{"speaker":"Unknown","startTime":1022.03,"endTime":1026.23,"body":"extraordinarily large school"},{"speaker":"Unknown","startTime":1026.23,"endTime":1029.53,"body":"with so many resources. So at"},{"speaker":"Unknown","startTime":1026.23,"endTime":1029.53,"body":"one point, I jumped from"},{"speaker":"Unknown","startTime":1029.53,"endTime":1033.43,"body":"business to chemistry, from"},{"speaker":"Unknown","startTime":1029.53,"endTime":1033.43,"body":"chemistry to biology. At some"},{"speaker":"Unknown","startTime":1033.43,"endTime":1036.01,"body":"point, being South Asian, I was"},{"speaker":"Unknown","startTime":1033.43,"endTime":1036.01,"body":"pre-med. I was like, I guess"},{"speaker":"Unknown","startTime":1036.01,"endTime":1038.095,"body":"I'll be a doctor eventually,"},{"speaker":"Unknown","startTime":1036.01,"endTime":1038.095,"body":"because everyone's a doctor,"},{"speaker":"Unknown","startTime":1038.095,"endTime":1040.975,"body":"somehow, in our family. But it"},{"speaker":"Unknown","startTime":1038.095,"endTime":1040.975,"body":"really didn't tick me enough."},{"speaker":"Unknown","startTime":1040.975,"endTime":1044.395,"body":"And towards the end of my"},{"speaker":"Unknown","startTime":1040.975,"endTime":1044.395,"body":"undergrad, I graduated with a"},{"speaker":"Unknown","startTime":1044.395,"endTime":1048.655,"body":"degree in Asian studies, Liberal"},{"speaker":"Unknown","startTime":1044.395,"endTime":1048.655,"body":"Arts. I figured I would never"},{"speaker":"Unknown","startTime":1048.655,"endTime":1052.315,"body":"read a book about Japanese"},{"speaker":"Unknown","startTime":1048.655,"endTime":1052.315,"body":"anthropology or learn about"},{"speaker":"Unknown","startTime":1052.315,"endTime":1057.535,"body":"Southeast Asia. And when I got"},{"speaker":"Unknown","startTime":1052.315,"endTime":1057.535,"body":"into grad school, molecular and"},{"speaker":"Unknown","startTime":1057.535,"endTime":1061.66,"body":"cell biology, interesting. I"},{"speaker":"Unknown","startTime":1057.535,"endTime":1061.66,"body":"think I was two and a half years"},{"speaker":"Unknown","startTime":1061.66,"endTime":1066.1,"body":"into it, on a microscope,"},{"speaker":"Unknown","startTime":1061.66,"endTime":1066.1,"body":"looking at C elegans and"},{"speaker":"Unknown","startTime":1066.1,"endTime":1069.76,"body":"counting these eggs that were"},{"speaker":"Unknown","startTime":1066.1,"endTime":1069.76,"body":"hatching out of these CMA, SMA,"},{"speaker":"Unknown","startTime":1069.76,"endTime":1073.96,"body":"long knockouts. I got bored"},{"speaker":"Unknown","startTime":1069.76,"endTime":1073.96,"body":"again. I was like, Wait, is this"},{"speaker":"Unknown","startTime":1073.96,"endTime":1077.92,"body":"really it? What are we doing?"},{"speaker":"Unknown","startTime":1073.96,"endTime":1077.92,"body":"And by chance, and most of my"},{"speaker":"Unknown","startTime":1077.92,"endTime":1082.3,"body":"career has been one of"},{"speaker":"Unknown","startTime":1077.92,"endTime":1082.3,"body":"circumstance and chance, and"},{"speaker":"Unknown","startTime":1082.3,"endTime":1085.585,"body":"being confident about telling"},{"speaker":"Unknown","startTime":1082.3,"endTime":1085.585,"body":"people I am curious. So I met an"},{"speaker":"Unknown","startTime":1085.585,"endTime":1088.825,"body":"individual. Decided at that"},{"speaker":"Unknown","startTime":1085.585,"endTime":1088.825,"body":"point I was going to join him."},{"speaker":"Unknown","startTime":1088.825,"endTime":1092.245,"body":"He was one of the founding"},{"speaker":"Unknown","startTime":1088.825,"endTime":1092.245,"body":"partners at MPM capital, but was"},{"speaker":"Unknown","startTime":1092.245,"endTime":1096.805,"body":"running Bain and BCGs healthcare"},{"speaker":"Unknown","startTime":1092.245,"endTime":1096.805,"body":"practice. At some point, he ran"},{"speaker":"Unknown","startTime":1096.805,"endTime":1100.165,"body":"BCG for 26 years, and then Bain"},{"speaker":"Unknown","startTime":1096.805,"endTime":1100.165,"body":"for seven years on the life"},{"speaker":"Unknown","startTime":1100.165,"endTime":1105.576,"body":"science consulting side. And  it"},{"speaker":"Unknown","startTime":1100.165,"endTime":1105.576,"body":"was just the individual I"},{"speaker":"Unknown","startTime":1105.576,"endTime":1106.51,"body":"gravitated towards, and figured,"},{"speaker":"Unknown","startTime":1105.576,"endTime":1106.51,"body":"you know what, I'm going to take"},{"speaker":"Unknown","startTime":1106.51,"endTime":1111.01,"body":"a chance here. So again, going"},{"speaker":"Unknown","startTime":1106.51,"endTime":1111.01,"body":"back to a family that worked"},{"speaker":"Unknown","startTime":1111.01,"endTime":1113.83,"body":"really hard, that had clear"},{"speaker":"Unknown","startTime":1111.01,"endTime":1113.83,"body":"career paths, here's their"},{"speaker":"Unknown","startTime":1113.83,"endTime":1118.21,"body":"youngest son deciding to jump,"},{"speaker":"Unknown","startTime":1113.83,"endTime":1118.21,"body":"out of curiosity. But you know,"},{"speaker":"Unknown","startTime":1118.27,"endTime":1121.87,"body":"it was those moments that taught"},{"speaker":"Unknown","startTime":1118.27,"endTime":1121.87,"body":"me the most. When I joined the"},{"speaker":"Unknown","startTime":1121.87,"endTime":1125.53,"body":"investment banking side in seven"},{"speaker":"Unknown","startTime":1121.87,"endTime":1125.53,"body":"and eight, it was learning about"},{"speaker":"Unknown","startTime":1125.53,"endTime":1129.13,"body":"how companies were making good"},{"speaker":"Unknown","startTime":1125.53,"endTime":1129.13,"body":"decisions and bad ones. A lot of"},{"speaker":"Unknown","startTime":1129.13,"endTime":1132.535,"body":"companies were shutting down."},{"speaker":"Unknown","startTime":1129.13,"endTime":1132.535,"body":"And it went back to the, I was"},{"speaker":"Unknown","startTime":1132.535,"endTime":1135.415,"body":"curious about how do these"},{"speaker":"Unknown","startTime":1132.535,"endTime":1135.415,"body":"leaders make these decisions?"},{"speaker":"Unknown","startTime":1136.135,"endTime":1138.535,"body":"How are they actually going to"},{"speaker":"Unknown","startTime":1136.135,"endTime":1138.535,"body":"navigate through success? How"},{"speaker":"Unknown","startTime":1138.535,"endTime":1140.995,"body":"are they actually going to"},{"speaker":"Unknown","startTime":1138.535,"endTime":1140.995,"body":"succeed or fail and return money"},{"speaker":"Unknown","startTime":1140.995,"endTime":1144.775,"body":"to investors? As an advisor, we"},{"speaker":"Unknown","startTime":1140.995,"endTime":1144.775,"body":"had a chance to give them"},{"speaker":"Unknown","startTime":1144.775,"endTime":1150.295,"body":"options, but it was my first"},{"speaker":"Unknown","startTime":1144.775,"endTime":1150.295,"body":"foray. Inevitably, I did not"},{"speaker":"Unknown","startTime":1150.295,"endTime":1153.22,"body":"plan on being in biotech. I did"},{"speaker":"Unknown","startTime":1150.295,"endTime":1153.22,"body":"not plan on being in a"},{"speaker":"Unknown","startTime":1153.22,"endTime":1157.3,"body":"management role, but that"},{"speaker":"Unknown","startTime":1153.22,"endTime":1157.3,"body":"curiosity till this day, has led"},{"speaker":"Unknown","startTime":1157.3,"endTime":1161.5,"body":"me to a point where I've learned"},{"speaker":"Unknown","startTime":1157.3,"endTime":1161.5,"body":"about what I can do, I learned"},{"speaker":"Unknown","startTime":1161.5,"endTime":1165.22,"body":"about my own leadership style,"},{"speaker":"Unknown","startTime":1161.5,"endTime":1165.22,"body":"my ability to make decisions"},{"speaker":"Unknown","startTime":1165.22,"endTime":1169.12,"body":"with less information, and, most"},{"speaker":"Unknown","startTime":1165.22,"endTime":1169.12,"body":"importantly, my decisions to"},{"speaker":"Unknown","startTime":1169.72,"endTime":1174.76,"body":"connect with individuals more."},{"speaker":"Unknown","startTime":1169.72,"endTime":1174.76,"body":"And so, over the years, it's"},{"speaker":"Unknown","startTime":1174.76,"endTime":1178.465,"body":"less about doubt on why didn't I"},{"speaker":"Unknown","startTime":1174.76,"endTime":1178.465,"body":"have a direct shot from here to"},{"speaker":"Unknown","startTime":1178.465,"endTime":1184.105,"body":"the moon? It was more about I'm"},{"speaker":"Unknown","startTime":1178.465,"endTime":1184.105,"body":"more confident now about going"},{"speaker":"Unknown","startTime":1184.105,"endTime":1187.585,"body":"through curiosity. And again,"},{"speaker":"Unknown","startTime":1184.105,"endTime":1187.585,"body":"chance and fortune and luck are"},{"speaker":"Unknown","startTime":1187.585,"endTime":1191.245,"body":"definitely a part of it. But you"},{"speaker":"Unknown","startTime":1187.585,"endTime":1191.245,"body":"can come back and say, maybe you"},{"speaker":"Unknown","startTime":1191.245,"endTime":1194.905,"body":"were inevitably put in this"},{"speaker":"Unknown","startTime":1191.245,"endTime":1194.905,"body":"position because you followed"},{"speaker":"Unknown","startTime":1194.905,"endTime":1201.73,"body":"your curiosity. And so being in"},{"speaker":"Unknown","startTime":1194.905,"endTime":1201.73,"body":"biotech, I like to find mentors,"},{"speaker":"Unknown","startTime":1201.73,"endTime":1205.93,"body":"and I do have mentors who have"},{"speaker":"Unknown","startTime":1201.73,"endTime":1205.93,"body":"had similar paths where none of"},{"speaker":"Unknown","startTime":1205.93,"endTime":1210.49,"body":"us really kind of planned to be"},{"speaker":"Unknown","startTime":1205.93,"endTime":1210.49,"body":"here. But what has allowed us to"},{"speaker":"Unknown","startTime":1210.49,"endTime":1213.85,"body":"succeed goes back to the"},{"speaker":"Unknown","startTime":1210.49,"endTime":1213.85,"body":"foundation of what every company"},{"speaker":"Unknown","startTime":1213.85,"endTime":1217.03,"body":"has, it's great talent and a"},{"speaker":"Unknown","startTime":1213.85,"endTime":1217.03,"body":"long term vision."},{"speaker":"John Simboli","startTime":1217.9,"endTime":1220.96,"body":"Let me see if I"},{"speaker":"John Simboli","startTime":1217.9,"endTime":1220.96,"body":"can make a connection there. I'm"},{"speaker":"John Simboli","startTime":1220.96,"endTime":1223.72,"body":"going to refer to something"},{"speaker":"John Simboli","startTime":1220.96,"endTime":1223.72,"body":"that's kind of old, so you can"},{"speaker":"John Simboli","startTime":1223.72,"endTime":1226.84,"body":"let me know if it's just doesn't"},{"speaker":"John Simboli","startTime":1223.72,"endTime":1226.84,"body":"apply anymore. When I was doing"},{"speaker":"John Simboli","startTime":1226.84,"endTime":1231.1,"body":"my research, I came across the"},{"speaker":"John Simboli","startTime":1226.84,"endTime":1231.1,"body":"YouTube interview from, I think"},{"speaker":"John Simboli","startTime":1231.1,"endTime":1234.58,"body":"it's 2020, when you're talking"},{"speaker":"John Simboli","startTime":1231.1,"endTime":1234.58,"body":"about, you're obviously in a"},{"speaker":"John Simboli","startTime":1234.58,"endTime":1237.58,"body":"different role there, but you're"},{"speaker":"John Simboli","startTime":1234.58,"endTime":1237.58,"body":"talking about, I guess you could"},{"speaker":"John Simboli","startTime":1237.58,"endTime":1244.165,"body":"say the origin story for Nimbus"},{"speaker":"John Simboli","startTime":1237.58,"endTime":1244.165,"body":"and I felt it, in terms of an"},{"speaker":"John Simboli","startTime":1244.165,"endTime":1247.885,"body":"experiment, a curiosity about"},{"speaker":"John Simboli","startTime":1244.165,"endTime":1247.885,"body":"Schrodinger and all those"},{"speaker":"John Simboli","startTime":1248.245,"endTime":1251.065,"body":"things.That may be so old that"},{"speaker":"John Simboli","startTime":1248.245,"endTime":1251.065,"body":"it's not worth talking about"},{"speaker":"John Simboli","startTime":1251.065,"endTime":1254.305,"body":"this point. On the other hand,"},{"speaker":"John Simboli","startTime":1251.065,"endTime":1254.305,"body":"it struck me, I thought, this is"},{"speaker":"John Simboli","startTime":1254.305,"endTime":1259.105,"body":"an unusual reset. Is that useful"},{"speaker":"John Simboli","startTime":1254.305,"endTime":1259.105,"body":"in terms of talking about what"},{"speaker":"John Simboli","startTime":1259.165,"endTime":1259.945,"body":"your vision is?"},{"speaker":"Unknown","startTime":1259.92,"endTime":1263.493,"body":"There's a theme here,"},{"speaker":"Unknown","startTime":1259.92,"endTime":1263.493,"body":"John, about, about how we can go"},{"speaker":"Unknown","startTime":1263.56,"endTime":1267.2,"body":"about making breakthrough"},{"speaker":"Unknown","startTime":1263.56,"endTime":1267.2,"body":"medicines to impact patients."},{"speaker":"Unknown","startTime":1267.266,"endTime":1271.435,"body":"And I think that is, you know,"},{"speaker":"Unknown","startTime":1267.266,"endTime":1271.435,"body":"it's not as direct, not as clear"},{"speaker":"Unknown","startTime":1271.502,"endTime":1275.208,"body":"as some companies will say, I"},{"speaker":"Unknown","startTime":1271.502,"endTime":1275.208,"body":"have an mRNA vaccine for X"},{"speaker":"Unknown","startTime":1275.274,"endTime":1279.179,"body":"indication, or I'm going to"},{"speaker":"Unknown","startTime":1275.274,"endTime":1279.179,"body":"validate so and so pathway. And"},{"speaker":"Unknown","startTime":1279.245,"endTime":1283.15,"body":"purposefully, and probably not"},{"speaker":"Unknown","startTime":1279.245,"endTime":1283.15,"body":"surprising, now, I gravitate"},{"speaker":"Unknown","startTime":1283.216,"endTime":1287.121,"body":"towards that ability. And for"},{"speaker":"Unknown","startTime":1283.216,"endTime":1287.121,"body":"me, look, Nimbus is a biotech"},{"speaker":"Unknown","startTime":1287.187,"endTime":1291.356,"body":"that invents new small molecule"},{"speaker":"Unknown","startTime":1287.187,"endTime":1291.356,"body":"medicines for serious diseases."},{"speaker":"Unknown","startTime":1291.423,"endTime":1294.864,"body":"Across cancer, across"},{"speaker":"Unknown","startTime":1291.423,"endTime":1294.864,"body":"inflammation, across metabolic"},{"speaker":"Unknown","startTime":1294.93,"endTime":1299.232,"body":"disorders. And we're a team that"},{"speaker":"Unknown","startTime":1294.93,"endTime":1299.232,"body":"believes that you can do science"},{"speaker":"Unknown","startTime":1299.298,"endTime":1303.336,"body":"at the highest level and still"},{"speaker":"Unknown","startTime":1299.298,"endTime":1303.336,"body":"keep your soul intact. And our"},{"speaker":"Unknown","startTime":1303.402,"endTime":1307.108,"body":"soul is to eventually help"},{"speaker":"Unknown","startTime":1303.402,"endTime":1307.108,"body":"patients. And we don't define"},{"speaker":"Unknown","startTime":1307.174,"endTime":1310.814,"body":"it. And that curiosity has, I"},{"speaker":"Unknown","startTime":1307.174,"endTime":1310.814,"body":"believe, allowed us to be"},{"speaker":"Unknown","startTime":1310.88,"endTime":1314.851,"body":"successful. If I define success"},{"speaker":"Unknown","startTime":1310.88,"endTime":1314.851,"body":"as four molecules discovered"},{"speaker":"Unknown","startTime":1314.918,"endTime":1318.889,"body":"internally that have gone into"},{"speaker":"Unknown","startTime":1314.918,"endTime":1318.889,"body":"the clinic, and they're still"},{"speaker":"Unknown","startTime":1318.955,"endTime":1323.257,"body":"there; raising over $600 million"},{"speaker":"Unknown","startTime":1318.955,"endTime":1323.257,"body":"in 16 years, which is not a lot,"},{"speaker":"Unknown","startTime":1323.323,"endTime":1327.36,"body":"if you think about it, but yet"},{"speaker":"Unknown","startTime":1323.323,"endTime":1327.36,"body":"able to return over $4 billion"},{"speaker":"Unknown","startTime":1327.426,"endTime":1331.596,"body":"back to investors. And each one"},{"speaker":"Unknown","startTime":1327.426,"endTime":1331.596,"body":"of those data points, a company"},{"speaker":"Unknown","startTime":1331.662,"endTime":1335.964,"body":"would say is their definition of"},{"speaker":"Unknown","startTime":1331.662,"endTime":1335.964,"body":"success. Some would say it's the"},{"speaker":"Unknown","startTime":1336.03,"endTime":1340.001,"body":"clinic. Some would say it's the"},{"speaker":"Unknown","startTime":1336.03,"endTime":1340.001,"body":"ability to raise money. Some"},{"speaker":"Unknown","startTime":1340.067,"endTime":1344.038,"body":"would say it's the ability to"},{"speaker":"Unknown","startTime":1340.067,"endTime":1344.038,"body":"return money. I think we don't"},{"speaker":"Unknown","startTime":1344.104,"endTime":1347.744,"body":"think about it as myopic as"},{"speaker":"Unknown","startTime":1344.104,"endTime":1347.744,"body":"that. I think first we just"},{"speaker":"Unknown","startTime":1347.811,"endTime":1351.186,"body":"think about it as, what"},{"speaker":"Unknown","startTime":1347.811,"endTime":1351.186,"body":"celebrates at Nimbus is the"},{"speaker":"Unknown","startTime":1351.252,"endTime":1355.289,"body":"ability to say we've had four"},{"speaker":"Unknown","startTime":1351.252,"endTime":1355.289,"body":"INDs, and all have successfully"},{"speaker":"Unknown","startTime":1355.355,"endTime":1359.525,"body":"gone to the clinic. And knock on"},{"speaker":"Unknown","startTime":1355.355,"endTime":1359.525,"body":"wood, so far, all of our drugs"},{"speaker":"Unknown","startTime":1359.591,"endTime":1363.231,"body":"that we have invented are still"},{"speaker":"Unknown","startTime":1359.591,"endTime":1363.231,"body":"active in patients, and"},{"speaker":"Unknown","startTime":1363.297,"endTime":1367.467,"body":"everything else is a result of"},{"speaker":"Unknown","startTime":1363.297,"endTime":1367.467,"body":"that focus. And so the curiosity"},{"speaker":"Unknown","startTime":1367.533,"endTime":1371.636,"body":"part of our brain says, Where"},{"speaker":"Unknown","startTime":1367.533,"endTime":1371.636,"body":"can we make a difference? At any"},{"speaker":"Unknown","startTime":1371.703,"endTime":1375.674,"body":"level, we could have decided to"},{"speaker":"Unknown","startTime":1371.703,"endTime":1375.674,"body":"enter the GLP-1 race and say"},{"speaker":"Unknown","startTime":1375.74,"endTime":1379.645,"body":"we're going to make a small"},{"speaker":"Unknown","startTime":1375.74,"endTime":1379.645,"body":"molecule, or else GLP-1., Or we"},{"speaker":"Unknown","startTime":1379.711,"endTime":1383.682,"body":"decided, well, what's going to"},{"speaker":"Unknown","startTime":1379.711,"endTime":1383.682,"body":"happen in four or five years?"},{"speaker":"Unknown","startTime":1383.748,"endTime":1387.917,"body":"There's probably going to be a"},{"speaker":"Unknown","startTime":1383.748,"endTime":1387.917,"body":"lot of GLP-1s that are emerging."},{"speaker":"Unknown","startTime":1387.984,"endTime":1391.955,"body":"You're probably not going to"},{"speaker":"Unknown","startTime":1387.984,"endTime":1391.955,"body":"overcome the challenges that if"},{"speaker":"Unknown","startTime":1392.021,"endTime":1395.661,"body":"you listen to the leaders in the"},{"speaker":"Unknown","startTime":1392.021,"endTime":1395.661,"body":"GLP-1 space of patient"},{"speaker":"Unknown","startTime":1395.727,"endTime":1399.698,"body":"experience, they want an oral"},{"speaker":"Unknown","startTime":1395.727,"endTime":1399.698,"body":"drug, great, but what else are"},{"speaker":"Unknown","startTime":1399.764,"endTime":1403.934,"body":"they dealing with? Well, they're"},{"speaker":"Unknown","startTime":1399.764,"endTime":1403.934,"body":"probably dealing with a lot of"},{"speaker":"Unknown","startTime":1404.0,"endTime":1407.64,"body":"lean muscle mass loss, and"},{"speaker":"Unknown","startTime":1404.0,"endTime":1407.64,"body":"that's the next wave. And so"},{"speaker":"Unknown","startTime":1407.706,"endTime":1411.545,"body":"there are a few targets that"},{"speaker":"Unknown","startTime":1407.706,"endTime":1411.545,"body":"Nimbus decided that we can go"},{"speaker":"Unknown","startTime":1411.611,"endTime":1415.78,"body":"after. Let's go after it. Let's"},{"speaker":"Unknown","startTime":1411.611,"endTime":1415.78,"body":"take that risk. And if we fail,"},{"speaker":"Unknown","startTime":1415.847,"endTime":1419.95,"body":"we have this platform, quote,"},{"speaker":"Unknown","startTime":1415.847,"endTime":1419.95,"body":"unquote, that we have an ability"},{"speaker":"Unknown","startTime":1420.016,"endTime":1423.987,"body":"to think about what are other"},{"speaker":"Unknown","startTime":1420.016,"endTime":1423.987,"body":"indications to go towards. And"},{"speaker":"Unknown","startTime":1424.053,"endTime":1427.76,"body":"those could be completely"},{"speaker":"Unknown","startTime":1424.053,"endTime":1427.76,"body":"outside of metabolic diseases."},{"speaker":"Unknown","startTime":1427.826,"endTime":1431.135,"body":"They could to be in"},{"speaker":"Unknown","startTime":1427.826,"endTime":1431.135,"body":"inflammation. It could be back"},{"speaker":"Unknown","startTime":1431.201,"endTime":1435.437,"body":"in oncology. And that, again, is"},{"speaker":"Unknown","startTime":1431.201,"endTime":1435.437,"body":"challenging on managing a team,"},{"speaker":"Unknown","startTime":1435.503,"endTime":1439.209,"body":"because you're oscillating"},{"speaker":"Unknown","startTime":1435.503,"endTime":1439.209,"body":"between such vast spaces. But"},{"speaker":"Unknown","startTime":1439.275,"endTime":1443.246,"body":"the culture I continue wanting"},{"speaker":"Unknown","startTime":1439.275,"endTime":1443.246,"body":"to cultivate is going back to"},{"speaker":"Unknown","startTime":1443.313,"endTime":1447.548,"body":"the basics of be curious and be"},{"speaker":"Unknown","startTime":1443.313,"endTime":1447.548,"body":"driven by the impact of patients"},{"speaker":"Unknown","startTime":1447.614,"endTime":1451.453,"body":"we're going to have. I think at"},{"speaker":"Unknown","startTime":1447.614,"endTime":1451.453,"body":"some point someone asked a"},{"speaker":"Unknown","startTime":1451.519,"endTime":1455.292,"body":"question around you're talking"},{"speaker":"Unknown","startTime":1451.519,"endTime":1455.292,"body":"about psoriasis, or you're"},{"speaker":"Unknown","startTime":1455.358,"endTime":1459.13,"body":"talking about IBD, that's not as"},{"speaker":"Unknown","startTime":1455.358,"endTime":1459.13,"body":"impactful as an oncology"},{"speaker":"Unknown","startTime":1459.196,"endTime":1463.167,"body":"company. I said, have you ever"},{"speaker":"Unknown","startTime":1459.196,"endTime":1463.167,"body":"been around a patient who has"},{"speaker":"Unknown","startTime":1463.234,"endTime":1467.403,"body":"IBD? Have you been a father or a"},{"speaker":"Unknown","startTime":1463.234,"endTime":1467.403,"body":"mother lifting their child off"},{"speaker":"Unknown","startTime":1467.469,"endTime":1471.44,"body":"the floor because they're in so"},{"speaker":"Unknown","startTime":1467.469,"endTime":1471.44,"body":"much pain from their Crohn's"},{"speaker":"Unknown","startTime":1471.506,"endTime":1475.544,"body":"disease or ulcerative colitis?"},{"speaker":"Unknown","startTime":1471.506,"endTime":1475.544,"body":"And so we're not ones to judge"},{"speaker":"Unknown","startTime":1475.61,"endTime":1478.853,"body":"an illness. We're ones to"},{"speaker":"Unknown","startTime":1475.61,"endTime":1478.853,"body":"decide, how can we help"},{"speaker":"Unknown","startTime":1478.919,"endTime":1483.221,"body":"alleviate their suffering? And I"},{"speaker":"Unknown","startTime":1478.919,"endTime":1483.221,"body":"think that is really hard to do."},{"speaker":"Unknown","startTime":1483.287,"endTime":1487.126,"body":"But knowing what we're good at,"},{"speaker":"Unknown","startTime":1483.287,"endTime":1487.126,"body":"and knowing that we have a"},{"speaker":"Unknown","startTime":1487.192,"endTime":1490.832,"body":"longer term vision, I think"},{"speaker":"Unknown","startTime":1487.192,"endTime":1490.832,"body":"really has driven and makes"},{"speaker":"Unknown","startTime":1490.898,"endTime":1495.001,"body":"Nimbus totally unique in this"},{"speaker":"Unknown","startTime":1490.898,"endTime":1495.001,"body":"sector. We build real medicines."},{"speaker":"Unknown","startTime":1495.068,"endTime":1498.575,"body":"We've done it again and again."},{"speaker":"Unknown","startTime":1495.068,"endTime":1498.575,"body":"Our approach is deeply"},{"speaker":"Unknown","startTime":1498.642,"endTime":1502.745,"body":"integrated. We bring together"},{"speaker":"Unknown","startTime":1498.642,"endTime":1502.745,"body":"computational chemistry, biology"},{"speaker":"Unknown","startTime":1502.811,"endTime":1506.451,"body":"and development from day one."},{"speaker":"Unknown","startTime":1502.811,"endTime":1506.451,"body":"And that speeds us up and"},{"speaker":"Unknown","startTime":1506.517,"endTime":1508.04,"body":"sharpens our decisions."},{"speaker":"John Simboli","startTime":1508.0,"endTime":1511.42,"body":"When people hear"},{"speaker":"John Simboli","startTime":1508.0,"endTime":1511.42,"body":"the thoughts you've been sharing"},{"speaker":"John Simboli","startTime":1511.42,"endTime":1516.28,"body":"and they say, Oh, I think I"},{"speaker":"John Simboli","startTime":1511.42,"endTime":1516.28,"body":"understand now, you're a x"},{"speaker":"John Simboli","startTime":1516.28,"endTime":1520.18,"body":"company, a platform company, you"},{"speaker":"John Simboli","startTime":1516.28,"endTime":1520.18,"body":"are a, you're in this space, and"},{"speaker":"John Simboli","startTime":1520.18,"endTime":1523.9,"body":"then you may think, well, that's"},{"speaker":"John Simboli","startTime":1520.18,"endTime":1523.9,"body":"part of the answer, but it's not"},{"speaker":"John Simboli","startTime":1523.9,"endTime":1527.74,"body":"really the answer. So is there a"},{"speaker":"John Simboli","startTime":1523.9,"endTime":1527.74,"body":"pattern when people kind of"},{"speaker":"John Simboli","startTime":1527.74,"endTime":1532.12,"body":"don't yet understand what"},{"speaker":"John Simboli","startTime":1527.74,"endTime":1532.12,"body":"categories they like to pigeon"},{"speaker":"John Simboli","startTime":1532.165,"endTime":1534.325,"body":"hole? How do you extricate"},{"speaker":"John Simboli","startTime":1532.165,"endTime":1534.325,"body":"yourself?"},{"speaker":"Unknown","startTime":1534.0,"endTime":1537.36,"body":"One form of"},{"speaker":"Unknown","startTime":1534.0,"endTime":1537.36,"body":"intelligence is the ability to"},{"speaker":"Unknown","startTime":1537.36,"endTime":1540.36,"body":"put things into categories, and"},{"speaker":"Unknown","startTime":1537.36,"endTime":1540.36,"body":"people try to do that with"},{"speaker":"Unknown","startTime":1540.36,"endTime":1545.58,"body":"Nimbus all the time. After our"},{"speaker":"Unknown","startTime":1540.36,"endTime":1545.58,"body":"NASH exit, we were the"},{"speaker":"Unknown","startTime":1546.12,"endTime":1550.5,"body":"metabolism company, and then"},{"speaker":"Unknown","startTime":1546.12,"endTime":1550.5,"body":"came TYK2, and we were suddenly,"},{"speaker":"Unknown","startTime":1550.5,"endTime":1554.64,"body":"oh, now you're an I\u0026I company."},{"speaker":"Unknown","startTime":1550.5,"endTime":1554.64,"body":"If it's not a therapeutic area,"},{"speaker":"Unknown","startTime":1554.64,"endTime":1557.88,"body":"it's a technology angle. Wait,"},{"speaker":"Unknown","startTime":1554.64,"endTime":1557.88,"body":"you're the first AI-enabled"},{"speaker":"Unknown","startTime":1557.88,"endTime":1561.165,"body":"company to take a molecule to"},{"speaker":"Unknown","startTime":1557.88,"endTime":1561.165,"body":"the clinic. You're a tech-bio"},{"speaker":"Unknown","startTime":1561.165,"endTime":1564.765,"body":"company, right? Aren't you very"},{"speaker":"Unknown","startTime":1561.165,"endTime":1564.765,"body":"similar to all the new tech-bio"},{"speaker":"Unknown","startTime":1565.245,"endTime":1569.625,"body":"phases? The truth is, and what"},{"speaker":"Unknown","startTime":1565.245,"endTime":1569.625,"body":"investors do like to hear, is"},{"speaker":"Unknown","startTime":1569.625,"endTime":1573.045,"body":"that we're not defined by a"},{"speaker":"Unknown","startTime":1569.625,"endTime":1573.045,"body":"single category. Not a single"},{"speaker":"Unknown","startTime":1573.045,"endTime":1577.965,"body":"asset, not a single partner or a"},{"speaker":"Unknown","startTime":1573.045,"endTime":1577.965,"body":"single investor. What makes"},{"speaker":"Unknown","startTime":1577.965,"endTime":1580.905,"body":"Nimbus differenct, and what"},{"speaker":"Unknown","startTime":1577.965,"endTime":1580.905,"body":"investors like to hear, is that,"},{"speaker":"Unknown","startTime":1581.31,"endTime":1584.49,"body":"A, we've repeatedly evolved."},{"speaker":"Unknown","startTime":1581.31,"endTime":1584.49,"body":"We've evolved from an ability to"},{"speaker":"Unknown","startTime":1584.49,"endTime":1588.27,"body":"say we're going to actually win"},{"speaker":"Unknown","startTime":1584.49,"endTime":1588.27,"body":"in the immunology space. We're"},{"speaker":"Unknown","startTime":1588.27,"endTime":1592.47,"body":"going to crack the code on how"},{"speaker":"Unknown","startTime":1588.27,"endTime":1592.47,"body":"to get a best in class, TYK2"},{"speaker":"Unknown","startTime":1592.47,"endTime":1596.91,"body":"inhibitor. We're also going to"},{"speaker":"Unknown","startTime":1592.47,"endTime":1596.91,"body":"be able to go from an idea into"},{"speaker":"Unknown","startTime":1596.91,"endTime":1601.29,"body":"the clinic and welcome attrition"},{"speaker":"Unknown","startTime":1596.91,"endTime":1601.29,"body":"as part of it. I have learned"},{"speaker":"Unknown","startTime":1601.29,"endTime":1605.475,"body":"investors equally celebrate our"},{"speaker":"Unknown","startTime":1601.29,"endTime":1605.475,"body":"ability to pause programs and"},{"speaker":"Unknown","startTime":1605.475,"endTime":1608.835,"body":"have the confidence to say we're"},{"speaker":"Unknown","startTime":1605.475,"endTime":1608.835,"body":"actually not going to work on"},{"speaker":"Unknown","startTime":1608.835,"endTime":1612.495,"body":"this investment as a thesis for"},{"speaker":"Unknown","startTime":1608.835,"endTime":1612.495,"body":"this drug. We're actually going"},{"speaker":"Unknown","startTime":1612.495,"endTime":1615.735,"body":"to take those resources and put"},{"speaker":"Unknown","startTime":1612.495,"endTime":1615.735,"body":"it against another asset. So I"},{"speaker":"Unknown","startTime":1615.735,"endTime":1620.115,"body":"remind people, the story isn't"},{"speaker":"Unknown","startTime":1615.735,"endTime":1620.115,"body":"just about the exits, it's this"},{"speaker":"Unknown","startTime":1620.115,"endTime":1623.295,"body":"engine. And I think at the end"},{"speaker":"Unknown","startTime":1620.115,"endTime":1623.295,"body":"of the day, John, where"},{"speaker":"Unknown","startTime":1623.295,"endTime":1626.175,"body":"investors want to get to with"},{"speaker":"Unknown","startTime":1623.295,"endTime":1626.175,"body":"Nimbus, it's the engine. And"},{"speaker":"Unknown","startTime":1626.175,"endTime":1630.84,"body":"when I talk about engine, it's"},{"speaker":"Unknown","startTime":1626.175,"endTime":1630.84,"body":"the team, it's the process, and"},{"speaker":"Unknown","startTime":1630.84,"endTime":1634.62,"body":"the scientific depth. The"},{"speaker":"Unknown","startTime":1630.84,"endTime":1634.62,"body":"cultural DNA allows us to keep"},{"speaker":"Unknown","startTime":1634.62,"endTime":1638.46,"body":"doing what we're doing. We then"},{"speaker":"Unknown","startTime":1634.62,"endTime":1638.46,"body":"get to this large pipeline, and"},{"speaker":"Unknown","startTime":1638.46,"endTime":1642.12,"body":"it feels like an a la carte, for"},{"speaker":"Unknown","startTime":1638.46,"endTime":1642.12,"body":"the investor to say, Well, where"},{"speaker":"Unknown","startTime":1642.12,"endTime":1646.2,"body":"is my liquidation event going to"},{"speaker":"Unknown","startTime":1642.12,"endTime":1646.2,"body":"come from? And we can, with high"},{"speaker":"Unknown","startTime":1646.2,"endTime":1649.74,"body":"intelligence and high"},{"speaker":"Unknown","startTime":1646.2,"endTime":1649.74,"body":"confidence, dig into a single"},{"speaker":"Unknown","startTime":1649.74,"endTime":1653.385,"body":"asset and talk about now, let's"},{"speaker":"Unknown","startTime":1649.74,"endTime":1653.385,"body":"talk about our Werner helicase"},{"speaker":"Unknown","startTime":1653.385,"endTime":1656.325,"body":"program. Why are we the best in"},{"speaker":"Unknown","startTime":1653.385,"endTime":1656.325,"body":"class? How are we going to"},{"speaker":"Unknown","startTime":1656.325,"endTime":1660.765,"body":"continue beating pharma like"},{"speaker":"Unknown","startTime":1656.325,"endTime":1660.765,"body":"Novartis and Roche and GSK? We"},{"speaker":"Unknown","startTime":1660.765,"endTime":1664.425,"body":"tend to put our hat in the ring"},{"speaker":"Unknown","startTime":1660.765,"endTime":1664.425,"body":"against the biggest. We'll talk"},{"speaker":"Unknown","startTime":1664.425,"endTime":1668.145,"body":"about our SIK2 program. And"},{"speaker":"Unknown","startTime":1664.425,"endTime":1668.145,"body":"investors now can say, wow. Do I"},{"speaker":"Unknown","startTime":1668.145,"endTime":1671.445,"body":"want to take a bet on an"},{"speaker":"Unknown","startTime":1668.145,"endTime":1671.445,"body":"oncology play with a very"},{"speaker":"Unknown","startTime":1671.445,"endTime":1674.31,"body":"competitive landscape, or do I"},{"speaker":"Unknown","startTime":1671.445,"endTime":1674.31,"body":"want to go into an immunology"},{"speaker":"Unknown","startTime":1674.31,"endTime":1679.83,"body":"play where Nimbus is advancing a"},{"speaker":"Unknown","startTime":1674.31,"endTime":1679.83,"body":"selective SIK2 program? Is there"},{"speaker":"Unknown","startTime":1679.83,"endTime":1684.21,"body":"space in the I\u0026I world of this"},{"speaker":"Unknown","startTime":1679.83,"endTime":1684.21,"body":"novel mechanism? How will this"},{"speaker":"Unknown","startTime":1684.21,"endTime":1687.33,"body":"hold true? And you talk to our"},{"speaker":"Unknown","startTime":1684.21,"endTime":1687.33,"body":"team, and they see that"},{"speaker":"Unknown","startTime":1687.33,"endTime":1691.11,"body":"conviction, you can start seeing"},{"speaker":"Unknown","startTime":1687.33,"endTime":1691.11,"body":"the investor thesis formulate"},{"speaker":"Unknown","startTime":1691.11,"endTime":1696.27,"body":"together. And where they end up"},{"speaker":"Unknown","startTime":1691.11,"endTime":1696.27,"body":"is, here is a company—and for"},{"speaker":"Unknown","startTime":1696.27,"endTime":1699.495,"body":"me, on a personal leadership"},{"speaker":"Unknown","startTime":1696.27,"endTime":1699.495,"body":"side, I love the oscillation"},{"speaker":"Unknown","startTime":1699.495,"endTime":1705.075,"body":"between balancing conviction and"},{"speaker":"Unknown","startTime":1699.495,"endTime":1705.075,"body":"discipline. And every investor"},{"speaker":"Unknown","startTime":1705.075,"endTime":1708.555,"body":"we talk to, and again, I'm so"},{"speaker":"Unknown","startTime":1705.075,"endTime":1708.555,"body":"fortunate to have an investor"},{"speaker":"Unknown","startTime":1708.555,"endTime":1713.115,"body":"base that goes from your venture"},{"speaker":"Unknown","startTime":1708.555,"endTime":1713.115,"body":"creation organizations, Atlas,"},{"speaker":"Unknown","startTime":1713.115,"endTime":1716.715,"body":"still a very strong supporter,"},{"speaker":"Unknown","startTime":1713.115,"endTime":1716.715,"body":"Lghtstone Ventures, you start"},{"speaker":"Unknown","startTime":1716.715,"endTime":1720.42,"body":"getting into the SR Ones of the"},{"speaker":"Unknown","startTime":1716.715,"endTime":1720.42,"body":"world, who do both public and"},{"speaker":"Unknown","startTime":1720.42,"endTime":1723.06,"body":"private, and then we have a lot"},{"speaker":"Unknown","startTime":1720.42,"endTime":1723.06,"body":"of crossover investors—Baker"},{"speaker":"Unknown","startTime":1723.24,"endTime":1729.36,"body":"Brothers, BVF, Google Ventures,"},{"speaker":"Unknown","startTime":1723.24,"endTime":1729.36,"body":"RA Capital, SV Health Investors."},{"speaker":"Unknown","startTime":1729.42,"endTime":1734.28,"body":"And so that broad spectrum has"},{"speaker":"Unknown","startTime":1729.42,"endTime":1734.28,"body":"taught me that, why do we have"},{"speaker":"Unknown","startTime":1734.28,"endTime":1738.78,"body":"such a broad investor base? It's"},{"speaker":"Unknown","startTime":1734.28,"endTime":1738.78,"body":"because we speak candidly about"},{"speaker":"Unknown","startTime":1738.96,"endTime":1743.385,"body":"where we can have conviction on"},{"speaker":"Unknown","startTime":1738.96,"endTime":1743.385,"body":"we're going to win, and yet"},{"speaker":"Unknown","startTime":1743.445,"endTime":1746.145,"body":"management applies discipline on"},{"speaker":"Unknown","startTime":1743.445,"endTime":1746.145,"body":"saying actually we're going to"},{"speaker":"Unknown","startTime":1746.145,"endTime":1748.545,"body":"save some capital dollars and"},{"speaker":"Unknown","startTime":1746.145,"endTime":1748.545,"body":"decide that we're not going to"},{"speaker":"Unknown","startTime":1748.545,"endTime":1751.725,"body":"progress X program, because we"},{"speaker":"Unknown","startTime":1748.545,"endTime":1751.725,"body":"don't see us actually winning."},{"speaker":"Unknown","startTime":1753.165,"endTime":1756.585,"body":"That, I think has worked in our"},{"speaker":"Unknown","startTime":1753.165,"endTime":1756.585,"body":"favor for years, and I want to"},{"speaker":"Unknown","startTime":1756.585,"endTime":1760.365,"body":"continue cultivating that,"},{"speaker":"Unknown","startTime":1756.585,"endTime":1760.365,"body":"knowing that right now I can"},{"speaker":"Unknown","startTime":1760.365,"endTime":1763.485,"body":"actually leave this meeting and"},{"speaker":"Unknown","startTime":1760.365,"endTime":1763.485,"body":"go to the next one and talk"},{"speaker":"Unknown","startTime":1763.485,"endTime":1765.75,"body":"about what's happening at ASCO,"},{"speaker":"Unknown","startTime":1763.485,"endTime":1765.75,"body":"how are we positioning our"},{"speaker":"Unknown","startTime":1765.75,"endTime":1769.11,"body":"molecule for the next year's"},{"speaker":"Unknown","startTime":1765.75,"endTime":1769.11,"body":"presentation? What's going on at"},{"speaker":"Unknown","startTime":1769.11,"endTime":1772.95,"body":"AAD? Where will our SIK2"},{"speaker":"Unknown","startTime":1769.11,"endTime":1772.95,"body":"compound fit? And that, I think,"},{"speaker":"Unknown","startTime":1772.95,"endTime":1776.43,"body":"is fun. It goes back to my"},{"speaker":"Unknown","startTime":1772.95,"endTime":1776.43,"body":"personality of I like being in"},{"speaker":"Unknown","startTime":1776.43,"endTime":1779.01,"body":"immunology one day and"},{"speaker":"Unknown","startTime":1776.43,"endTime":1779.01,"body":"metabolism the next day and"},{"speaker":"Unknown","startTime":1779.25,"endTime":1782.67,"body":"oncology the next day. So for"},{"speaker":"Unknown","startTime":1779.25,"endTime":1782.67,"body":"me, I found the perfect match."},{"speaker":"Unknown","startTime":1783.09,"endTime":1786.21,"body":"Go depth and breadth across the"},{"speaker":"Unknown","startTime":1783.09,"endTime":1786.21,"body":"board where we can make an"},{"speaker":"Unknown","startTime":1786.21,"endTime":1786.81,"body":"impact,"},{"speaker":"John Simboli","startTime":1787.815,"endTime":1794.295,"body":"This openness to"},{"speaker":"John Simboli","startTime":1787.815,"endTime":1794.295,"body":"breadth of challenges. How does"},{"speaker":"John Simboli","startTime":1794.295,"endTime":1798.135,"body":"that relate, if at all, to this"},{"speaker":"John Simboli","startTime":1794.295,"endTime":1798.135,"body":"idea that mega blockbuster is"},{"speaker":"John Simboli","startTime":1798.135,"endTime":1800.055,"body":"something that interests you?"},{"speaker":"Unknown","startTime":1799.38,"endTime":1802.498,"body":"I think, ultimately,"},{"speaker":"Unknown","startTime":1799.38,"endTime":1802.498,"body":"the business model, and going"},{"speaker":"Abbas Kazimi","startTime":1800.0,"endTime":1805.614,"body":"Let's just talk"},{"speaker":"Abbas Kazimi","startTime":1800.0,"endTime":1805.614,"body":"about one of our emerging"},{"speaker":"Abbas Kazimi","startTime":1802.561,"endTime":1806.178,"body":"back to one of your earlier"},{"speaker":"Abbas Kazimi","startTime":1802.561,"endTime":1806.178,"body":"questions, it's actually still"},{"speaker":"Abbas Kazimi","startTime":1805.751,"endTime":1813.145,"body":"programs, it's a salt-induced"},{"speaker":"Abbas Kazimi","startTime":1805.751,"endTime":1813.145,"body":"kinase 2. So, yes, we're"},{"speaker":"Abbas Kazimi","startTime":1806.241,"endTime":1809.921,"body":"in play today. The question"},{"speaker":"Abbas Kazimi","startTime":1806.241,"endTime":1809.921,"body":"around our formation was around"},{"speaker":"Abbas Kazimi","startTime":1809.983,"endTime":1813.289,"body":"number one, can we work with"},{"speaker":"Abbas Kazimi","startTime":1809.983,"endTime":1813.289,"body":"Schrodinger and discover"},{"speaker":"Abbas Kazimi","startTime":1813.282,"endTime":1821.361,"body":"virtual. So FTEs were still"},{"speaker":"Abbas Kazimi","startTime":1813.282,"endTime":1821.361,"body":"hovering around 75-80, 76 to be"},{"speaker":"Abbas Kazimi","startTime":1813.351,"endTime":1816.782,"body":"molecules in silico? As of"},{"speaker":"Abbas Kazimi","startTime":1813.351,"endTime":1816.782,"body":"today, we work with a lot of"},{"speaker":"Abbas Kazimi","startTime":1816.844,"endTime":1820.586,"body":"broader companies outside of"},{"speaker":"Abbas Kazimi","startTime":1816.844,"endTime":1820.586,"body":"Schrodinger. They're one of our"},{"speaker":"Abbas Kazimi","startTime":1820.649,"endTime":1824.391,"body":"partners, but we have a number"},{"speaker":"Abbas Kazimi","startTime":1820.649,"endTime":1824.391,"body":"of them to continue advancing"},{"speaker":"Abbas Kazimi","startTime":1821.498,"endTime":1830.262,"body":"precise,. 80, because we have a"},{"speaker":"Abbas Kazimi","startTime":1821.498,"endTime":1830.262,"body":"few consultants that we're going"},{"speaker":"Abbas Kazimi","startTime":1824.453,"endTime":1828.196,"body":"our ability. Number two, the"},{"speaker":"Abbas Kazimi","startTime":1824.453,"endTime":1828.196,"body":"second business model principle"},{"speaker":"Abbas Kazimi","startTime":1828.258,"endTime":1832.125,"body":"was, can we still be virtual?"},{"speaker":"Abbas Kazimi","startTime":1828.258,"endTime":1832.125,"body":"That still holds true today. But"},{"speaker":"Abbas Kazimi","startTime":1830.399,"endTime":1837.93,"body":"to bring on board and but we"},{"speaker":"Abbas Kazimi","startTime":1830.399,"endTime":1837.93,"body":"have this, this feeling of"},{"speaker":"Abbas Kazimi","startTime":1832.188,"endTime":1835.992,"body":"to answer your question, the"},{"speaker":"Abbas Kazimi","startTime":1832.188,"endTime":1835.992,"body":"third part of it is our business"},{"speaker":"Abbas Kazimi","startTime":1836.055,"endTime":1839.735,"body":"structure. We're still a LLC"},{"speaker":"Abbas Kazimi","startTime":1836.055,"endTime":1839.735,"body":"holding company. And what that"},{"speaker":"Abbas Kazimi","startTime":1838.067,"endTime":1846.146,"body":"hundreds of FTEs because we've"},{"speaker":"Abbas Kazimi","startTime":1838.067,"endTime":1846.146,"body":"had these relationships with"},{"speaker":"Abbas Kazimi","startTime":1839.797,"endTime":1843.602,"body":"implies is that ultimately, as"},{"speaker":"Abbas Kazimi","startTime":1839.797,"endTime":1843.602,"body":"of today, there is going to be"},{"speaker":"Abbas Kazimi","startTime":1843.664,"endTime":1847.469,"body":"an eventual exit to a partner."},{"speaker":"Abbas Kazimi","startTime":1843.664,"endTime":1847.469,"body":"Now, our last program that was"},{"speaker":"Abbas Kazimi","startTime":1846.283,"endTime":1854.499,"body":"either consultants that have"},{"speaker":"Abbas Kazimi","startTime":1846.283,"endTime":1854.499,"body":"been working with us for years,"},{"speaker":"Abbas Kazimi","startTime":1847.531,"endTime":1851.586,"body":"in phase 2b, multiple we had two"},{"speaker":"Abbas Kazimi","startTime":1847.531,"endTime":1851.586,"body":"phase 2bs ongoing. We were ready"},{"speaker":"Abbas Kazimi","startTime":1851.648,"endTime":1855.64,"body":"to get our CRO to raise money if"},{"speaker":"Abbas Kazimi","startTime":1851.648,"endTime":1855.64,"body":"we needed to bring on Bain. And"},{"speaker":"Abbas Kazimi","startTime":1854.636,"endTime":1863.4,"body":"but more specifically, the CROs"},{"speaker":"Abbas Kazimi","startTime":1854.636,"endTime":1863.4,"body":"we have been working with. We've"},{"speaker":"Abbas Kazimi","startTime":1855.702,"endTime":1859.569,"body":"Bain came in and supported us"},{"speaker":"Abbas Kazimi","startTime":1855.702,"endTime":1859.569,"body":"multiple times to get that phase"},{"speaker":"Abbas Kazimi","startTime":1859.632,"endTime":1863.437,"body":"three ready launch, knowing that"},{"speaker":"Abbas Kazimi","startTime":1859.632,"endTime":1863.437,"body":"if we launched a phase three"},{"speaker":"Abbas Kazimi","startTime":1863.499,"endTime":1867.304,"body":"study, we would probably start"},{"speaker":"Abbas Kazimi","startTime":1863.499,"endTime":1867.304,"body":"thinking about sale. We've had"},{"speaker":"Abbas Kazimi","startTime":1863.537,"endTime":1871.753,"body":"known them for over 15 years."},{"speaker":"Abbas Kazimi","startTime":1863.537,"endTime":1871.753,"body":"Any company can come today and"},{"speaker":"Abbas Kazimi","startTime":1867.366,"endTime":1870.984,"body":"business engagements across all"},{"speaker":"Abbas Kazimi","startTime":1867.366,"endTime":1870.984,"body":"of our programs the day we"},{"speaker":"Abbas Kazimi","startTime":1871.046,"endTime":1874.976,"body":"announce them. Even now some of"},{"speaker":"Abbas Kazimi","startTime":1871.046,"endTime":1874.976,"body":"our, even unannounced programs,"},{"speaker":"Abbas Kazimi","startTime":1871.89,"endTime":1880.38,"body":"start a virtual model, I think"},{"speaker":"Abbas Kazimi","startTime":1871.89,"endTime":1880.38,"body":"what you can start Is this, the"},{"speaker":"Abbas Kazimi","startTime":1875.038,"endTime":1878.967,"body":"there's BD partnering interest."},{"speaker":"Abbas Kazimi","startTime":1875.038,"endTime":1878.967,"body":"So we nominate our new targets,"},{"speaker":"Abbas Kazimi","startTime":1879.03,"endTime":1882.336,"body":"at a fundamental level we think"},{"speaker":"Abbas Kazimi","startTime":1879.03,"endTime":1882.336,"body":"about, is that target"},{"speaker":"Abbas Kazimi","startTime":1880.516,"endTime":1887.363,"body":"human element of the"},{"speaker":"Abbas Kazimi","startTime":1880.516,"endTime":1887.363,"body":"relationship. So when we call"},{"speaker":"Abbas Kazimi","startTime":1882.398,"endTime":1886.14,"body":"genetically validated? Is there"},{"speaker":"Abbas Kazimi","startTime":1882.398,"endTime":1886.14,"body":"biology that we can actually"},{"speaker":"Abbas Kazimi","startTime":1886.203,"endTime":1889.696,"body":"utilize and move quickly? Is"},{"speaker":"Abbas Kazimi","startTime":1886.203,"endTime":1889.696,"body":"there chemistry that we can"},{"speaker":"Abbas Kazimi","startTime":1887.5,"endTime":1895.305,"body":"our colleagues at Wu Xi or"},{"speaker":"Abbas Kazimi","startTime":1887.5,"endTime":1895.305,"body":"Pharmaran or Aurigene in India"},{"speaker":"Abbas Kazimi","startTime":1889.758,"endTime":1893.189,"body":"actually get ligands to"},{"speaker":"Abbas Kazimi","startTime":1889.758,"endTime":1893.189,"body":"prosecute that program? But the"},{"speaker":"Abbas Kazimi","startTime":1893.251,"endTime":1896.869,"body":"fourth leg of that chair is what"},{"speaker":"Abbas Kazimi","startTime":1893.251,"endTime":1896.869,"body":"is a potential commercial"},{"speaker":"Abbas Kazimi","startTime":1895.442,"endTime":1904.069,"body":"or Charles River, we're calling"},{"speaker":"Abbas Kazimi","startTime":1895.442,"endTime":1904.069,"body":"them by name. We're calling, by"},{"speaker":"Abbas Kazimi","startTime":1896.931,"endTime":1899.925,"body":"opportunity? So mega"},{"speaker":"Abbas Kazimi","startTime":1896.931,"endTime":1899.925,"body":"blockbusters, pipeline in a"},{"speaker":"Abbas Kazimi","startTime":1899.987,"endTime":1903.792,"body":"pill, is kind of where people"},{"speaker":"Abbas Kazimi","startTime":1899.987,"endTime":1903.792,"body":"are focusing. We'll think about"},{"speaker":"Abbas Kazimi","startTime":1903.854,"endTime":1907.721,"body":"how to balance our portfolio."},{"speaker":"Abbas Kazimi","startTime":1903.854,"endTime":1907.721,"body":"There are some programs like our"},{"speaker":"Abbas Kazimi","startTime":1904.206,"endTime":1912.559,"body":"name, these 10 med chemists on"},{"speaker":"Abbas Kazimi","startTime":1904.206,"endTime":1912.559,"body":"this project. And when we talk"},{"speaker":"Abbas Kazimi","startTime":1907.784,"endTime":1911.589,"body":"salt induced kinase 2 program,"},{"speaker":"Abbas Kazimi","startTime":1907.784,"endTime":1911.589,"body":"SIK2, which we think is a mega"},{"speaker":"Abbas Kazimi","startTime":1911.651,"endTime":1915.206,"body":"blockbuster. It's indicated"},{"speaker":"Abbas Kazimi","startTime":1911.651,"endTime":1915.206,"body":"across multiple cytokines. It"},{"speaker":"Abbas Kazimi","startTime":1912.696,"endTime":1921.186,"body":"about a project, we talk about,"},{"speaker":"Abbas Kazimi","startTime":1912.696,"endTime":1921.186,"body":"what are we trying to achieve?"},{"speaker":"Abbas Kazimi","startTime":1915.269,"endTime":1918.262,"body":"can actually give"},{"speaker":"Abbas Kazimi","startTime":1915.269,"endTime":1918.262,"body":"pro-inflammatory resolution to"},{"speaker":"Abbas Kazimi","startTime":1918.325,"endTime":1921.755,"body":"inflammatory diseases. So any"},{"speaker":"Abbas Kazimi","startTime":1918.325,"endTime":1921.755,"body":"partner would think about"},{"speaker":"Abbas Kazimi","startTime":1921.323,"endTime":1930.223,"body":"So salt induced kinase 2, it's a"},{"speaker":"Abbas Kazimi","startTime":1921.323,"endTime":1930.223,"body":"program that Galapagos attempted"},{"speaker":"Abbas Kazimi","startTime":1921.818,"endTime":1925.685,"body":"Nimbus, get your best molecules"},{"speaker":"Abbas Kazimi","startTime":1921.818,"endTime":1925.685,"body":"to the clinic, and we're going"},{"speaker":"Abbas Kazimi","startTime":1925.747,"endTime":1929.053,"body":"to take over and go fairly"},{"speaker":"Abbas Kazimi","startTime":1925.747,"endTime":1929.053,"body":"broad, just as we did with"},{"speaker":"Abbas Kazimi","startTime":1929.115,"endTime":1932.546,"body":"TYK2,. The other spectrum,"},{"speaker":"Abbas Kazimi","startTime":1929.115,"endTime":1932.546,"body":"oncology, our Werner program"},{"speaker":"Abbas Kazimi","startTime":1930.36,"endTime":1937.892,"body":"to go after. They kind of"},{"speaker":"Abbas Kazimi","startTime":1930.36,"endTime":1937.892,"body":"muddied the water. They had a"},{"speaker":"Abbas Kazimi","startTime":1932.608,"endTime":1936.039,"body":"synthetic lethal target, it's"},{"speaker":"Abbas Kazimi","startTime":1932.608,"endTime":1936.039,"body":"very specific to MSI high"},{"speaker":"Abbas Kazimi","startTime":1936.101,"endTime":1939.345,"body":"patients. And until today,"},{"speaker":"Abbas Kazimi","startTime":1936.101,"endTime":1939.345,"body":"people are still thinking"},{"speaker":"Abbas Kazimi","startTime":1938.029,"endTime":1945.697,"body":"pan-SIK inhibitor, meaning"},{"speaker":"Abbas Kazimi","startTime":1938.029,"endTime":1945.697,"body":"there's three isoforms, SIK1,"},{"speaker":"Abbas Kazimi","startTime":1939.407,"endTime":1943.149,"body":"through between endometrial"},{"speaker":"Abbas Kazimi","startTime":1939.407,"endTime":1943.149,"body":"gastric cancers, how big is that"},{"speaker":"Abbas Kazimi","startTime":1943.212,"endTime":1946.58,"body":"patient population? So"},{"speaker":"Abbas Kazimi","startTime":1943.212,"endTime":1946.58,"body":"commercially, the question will"},{"speaker":"Abbas Kazimi","startTime":1945.834,"endTime":1954.187,"body":"SIK2, SIK3, and they're very"},{"speaker":"Abbas Kazimi","startTime":1945.834,"endTime":1954.187,"body":"close to each other. So this was"},{"speaker":"Abbas Kazimi","startTime":1946.642,"endTime":1950.197,"body":"be there. For Nimbus, it's an"},{"speaker":"Abbas Kazimi","startTime":1946.642,"endTime":1950.197,"body":"opportunity to still impact"},{"speaker":"Abbas Kazimi","startTime":1950.26,"endTime":1954.189,"body":"those patients who aren't doing"},{"speaker":"Abbas Kazimi","startTime":1950.26,"endTime":1954.189,"body":"well on a PD-1 or refractory or"},{"speaker":"Abbas Kazimi","startTime":1954.252,"endTime":1958.119,"body":"relapse. And again, it's also an"},{"speaker":"Abbas Kazimi","startTime":1954.252,"endTime":1958.119,"body":"ability to say we can balance"},{"speaker":"Abbas Kazimi","startTime":1954.324,"endTime":1962.814,"body":"an opportunity to say, is there"},{"speaker":"Abbas Kazimi","startTime":1954.324,"endTime":1962.814,"body":"a thesis that we have? And the"},{"speaker":"Abbas Kazimi","startTime":1958.181,"endTime":1962.111,"body":"our portfolio between what you"},{"speaker":"Abbas Kazimi","startTime":1958.181,"endTime":1962.111,"body":"call a mega blockbuster, but yet"},{"speaker":"Abbas Kazimi","startTime":1962.173,"endTime":1965.728,"body":"a drug that Nimbus feels is"},{"speaker":"Abbas Kazimi","startTime":1962.173,"endTime":1965.728,"body":"going to be best in class and"},{"speaker":"Abbas Kazimi","startTime":1962.95,"endTime":1970.893,"body":"hypothesis we wanted to test"},{"speaker":"Abbas Kazimi","startTime":1962.95,"endTime":1970.893,"body":"was, what if we go after SIK2"},{"speaker":"Abbas Kazimi","startTime":1965.791,"endTime":1969.658,"body":"will still impact patients. So"},{"speaker":"Abbas Kazimi","startTime":1965.791,"endTime":1969.658,"body":"we think about that at an early"},{"speaker":"Abbas Kazimi","startTime":1969.72,"endTime":1973.712,"body":"level. I think it's a portfolio"},{"speaker":"Abbas Kazimi","startTime":1969.72,"endTime":1973.712,"body":"that you can manage those risks."},{"speaker":"Abbas Kazimi","startTime":1971.03,"endTime":1979.383,"body":"only it's a powerful metabolic,"},{"speaker":"Abbas Kazimi","startTime":1971.03,"endTime":1979.383,"body":"immunometabolic target at the"},{"speaker":"Abbas Kazimi","startTime":1973.774,"endTime":1977.33,"body":"You know my colleagues who I"},{"speaker":"Abbas Kazimi","startTime":1973.774,"endTime":1977.33,"body":"talk to, I would say once or"},{"speaker":"Abbas Kazimi","startTime":1977.392,"endTime":1981.072,"body":"twice a week from different"},{"speaker":"Abbas Kazimi","startTime":1977.392,"endTime":1981.072,"body":"pharma relationships, we're not"},{"speaker":"Abbas Kazimi","startTime":1979.519,"endTime":1988.009,"body":"intersection of inflammation and"},{"speaker":"Abbas Kazimi","startTime":1979.519,"endTime":1988.009,"body":"innate immunity. It regulates"},{"speaker":"Abbas Kazimi","startTime":1981.134,"endTime":1984.128,"body":"always doing BD, but we're"},{"speaker":"Abbas Kazimi","startTime":1981.134,"endTime":1984.128,"body":"always building those"},{"speaker":"Abbas Kazimi","startTime":1984.191,"endTime":1987.871,"body":"relationships. They want to"},{"speaker":"Abbas Kazimi","startTime":1984.191,"endTime":1987.871,"body":"know, hey, that early metabolic"},{"speaker":"Abbas Kazimi","startTime":1987.933,"endTime":1991.488,"body":"program, where is it? Are you"},{"speaker":"Abbas Kazimi","startTime":1987.933,"endTime":1991.488,"body":"talking about partnerships?"},{"speaker":"Abbas Kazimi","startTime":1988.146,"endTime":1996.088,"body":"key immune cells inflammatory"},{"speaker":"Abbas Kazimi","startTime":1988.146,"endTime":1996.088,"body":"pathways, including cytokine"},{"speaker":"Abbas Kazimi","startTime":1991.551,"endTime":1995.543,"body":"Nope, we have confidence we can"},{"speaker":"Abbas Kazimi","startTime":1991.551,"endTime":1995.543,"body":"take it fairly far. And when you"},{"speaker":"Abbas Kazimi","startTime":1995.605,"endTime":1999.347,"body":"say, No, you and I both know"},{"speaker":"Abbas Kazimi","startTime":1995.605,"endTime":1999.347,"body":"people get more interested, and"},{"speaker":"Abbas Kazimi","startTime":1996.225,"endTime":2004.852,"body":"production and the resolution of"},{"speaker":"Abbas Kazimi","startTime":1996.225,"endTime":2004.852,"body":"inflammation. So at Nimbus, we"},{"speaker":"Abbas Kazimi","startTime":1999.41,"endTime":2003.152,"body":"so they want to start digging"},{"speaker":"Abbas Kazimi","startTime":1999.41,"endTime":2003.152,"body":"deeper. And that's not just to"},{"speaker":"Abbas Kazimi","startTime":2003.215,"endTime":2007.082,"body":"say we have a strategy there."},{"speaker":"Abbas Kazimi","startTime":2003.215,"endTime":2007.082,"body":"It's honestly, I love being very"},{"speaker":"Abbas Kazimi","startTime":2004.989,"endTime":2013.479,"body":"said, how can we do this? Using"},{"speaker":"Abbas Kazimi","startTime":2004.989,"endTime":2013.479,"body":"our computational tools, using"},{"speaker":"Abbas Kazimi","startTime":2007.144,"endTime":2011.011,"body":"open with people. I love being"},{"speaker":"Abbas Kazimi","startTime":2007.144,"endTime":2011.011,"body":"very candid of what I think our"},{"speaker":"Abbas Kazimi","startTime":2011.074,"endTime":2014.504,"body":"team can do and where I think"},{"speaker":"Abbas Kazimi","startTime":2011.074,"endTime":2014.504,"body":"our team can benefit from"},{"speaker":"Abbas Kazimi","startTime":2013.616,"endTime":2021.969,"body":"our ability to work with not"},{"speaker":"Abbas Kazimi","startTime":2013.616,"endTime":2021.969,"body":"just one platform, but a variety"},{"speaker":"Abbas Kazimi","startTime":2014.566,"endTime":2018.122,"body":"partnering. So we like to"},{"speaker":"Abbas Kazimi","startTime":2014.566,"endTime":2018.122,"body":"balance that portfolio. And you"},{"speaker":"Abbas Kazimi","startTime":2018.184,"endTime":2021.552,"body":"know, in a year like this, in"},{"speaker":"Abbas Kazimi","startTime":2018.184,"endTime":2021.552,"body":"2025 we have not stopped"},{"speaker":"Abbas Kazimi","startTime":2021.615,"endTime":2024.92,"body":"thinking about the next"},{"speaker":"Abbas Kazimi","startTime":2021.615,"endTime":2024.92,"body":"generation of targets. And so"},{"speaker":"Abbas Kazimi","startTime":2022.106,"endTime":2029.226,"body":"of different partners, to,"},{"speaker":"Abbas Kazimi","startTime":2022.106,"endTime":2029.226,"body":"number one, generate this"},{"speaker":"Abbas Kazimi","startTime":2024.983,"endTime":2028.85,"body":"our Gantt chart will go out to"},{"speaker":"Abbas Kazimi","startTime":2024.983,"endTime":2028.85,"body":"28-29 with our current programs"},{"speaker":"Abbas Kazimi","startTime":2028.912,"endTime":2032.655,"body":"as leads. But yet we have this"},{"speaker":"Abbas Kazimi","startTime":2028.912,"endTime":2032.655,"body":"massive investment about what"},{"speaker":"Abbas Kazimi","startTime":2029.363,"endTime":2037.442,"body":"protein structure, look at that"},{"speaker":"Abbas Kazimi","startTime":2029.363,"endTime":2037.442,"body":"protein and figure out, are"},{"speaker":"Abbas Kazimi","startTime":2032.717,"endTime":2036.522,"body":"are the new targets coming up,"},{"speaker":"Abbas Kazimi","startTime":2032.717,"endTime":2036.522,"body":"knowing that we're still going"},{"speaker":"Abbas Kazimi","startTime":2036.584,"endTime":2040.389,"body":"to probably average between our"},{"speaker":"Abbas Kazimi","startTime":2036.584,"endTime":2040.389,"body":"70 to 75% attrition rate. And"},{"speaker":"Abbas Kazimi","startTime":2037.579,"endTime":2045.521,"body":"there pockets that we actually"},{"speaker":"Abbas Kazimi","startTime":2037.579,"endTime":2045.521,"body":"can go after? And then two,"},{"speaker":"Abbas Kazimi","startTime":2040.451,"endTime":2044.256,"body":"the team is confident in that."},{"speaker":"Abbas Kazimi","startTime":2040.451,"endTime":2044.256,"body":"They're confident knowing that"},{"speaker":"Abbas Kazimi","startTime":2044.318,"endTime":2048.185,"body":"one of these will actually do"},{"speaker":"Abbas Kazimi","startTime":2044.318,"endTime":2048.185,"body":"something that's going to return"},{"speaker":"Abbas Kazimi","startTime":2045.658,"endTime":2054.011,"body":"drive with our computational"},{"speaker":"Abbas Kazimi","startTime":2045.658,"endTime":2054.011,"body":"tools such high selectivity that"},{"speaker":"Abbas Kazimi","startTime":2048.248,"endTime":2051.367,"body":"money to investors. One of"},{"speaker":"Abbas Kazimi","startTime":2048.248,"endTime":2051.367,"body":"these, or two of these,"},{"speaker":"Abbas Kazimi","startTime":2051.429,"endTime":2055.421,"body":"hopefully will go to the clinic"},{"speaker":"Abbas Kazimi","startTime":2051.429,"endTime":2055.421,"body":"and continue impacting patients,"},{"speaker":"Abbas Kazimi","startTime":2054.148,"endTime":2061.543,"body":"we're going to get a SIK2"},{"speaker":"Abbas Kazimi","startTime":2054.148,"endTime":2061.543,"body":"inhibitor that no one's seen"},{"speaker":"Abbas Kazimi","startTime":2055.483,"endTime":2058.789,"body":"and one of these programs may"},{"speaker":"Abbas Kazimi","startTime":2055.483,"endTime":2058.789,"body":"stop because there's an"},{"speaker":"Abbas Kazimi","startTime":2058.851,"endTime":2062.469,"body":"opportunity cost to work on"},{"speaker":"Abbas Kazimi","startTime":2058.851,"endTime":2062.469,"body":"another program. to either, A,"},{"speaker":"Abbas Kazimi","startTime":2061.68,"endTime":2070.306,"body":"before, and biologically start"},{"speaker":"Abbas Kazimi","startTime":2061.68,"endTime":2070.306,"body":"showing robust anti-inflammatory"},{"speaker":"Abbas Kazimi","startTime":2062.531,"endTime":2066.398,"body":"go to broader patients, or, B, a"},{"speaker":"Abbas Kazimi","startTime":2062.531,"endTime":2066.398,"body":"smaller set. So again, my job"},{"speaker":"Abbas Kazimi","startTime":2066.461,"endTime":2070.141,"body":"has always been in my career to"},{"speaker":"Abbas Kazimi","startTime":2066.461,"endTime":2070.141,"body":"create those options, and I"},{"speaker":"Abbas Kazimi","startTime":2070.203,"endTime":2074.07,"body":"think we're very fortunate to be"},{"speaker":"Abbas Kazimi","startTime":2070.203,"endTime":2074.07,"body":"able to have a portfolio that"},{"speaker":"Abbas Kazimi","startTime":2070.443,"endTime":2078.659,"body":"effects without this kind of"},{"speaker":"Abbas Kazimi","startTime":2070.443,"endTime":2078.659,"body":"broad immune suppression you've"},{"speaker":"Abbas Kazimi","startTime":2074.133,"endTime":2078.0,"body":"gives us optionality. Our board"},{"speaker":"Abbas Kazimi","startTime":2074.133,"endTime":2078.0,"body":"meetings are fun. Some may not"},{"speaker":"Abbas Kazimi","startTime":2078.062,"endTime":2081.617,"body":"agree, but for me, they're fun"},{"speaker":"Abbas Kazimi","startTime":2078.062,"endTime":2081.617,"body":"because you have strategic"},{"speaker":"Abbas Kazimi","startTime":2078.796,"endTime":2087.012,"body":"seen in other approaches, and"},{"speaker":"Abbas Kazimi","startTime":2078.796,"endTime":2087.012,"body":"we've achieved that again. And"},{"speaker":"Abbas Kazimi","startTime":2081.68,"endTime":2085.422,"body":"conversations on which path do"},{"speaker":"Abbas Kazimi","startTime":2081.68,"endTime":2085.422,"body":"you want to take forward. And"},{"speaker":"Abbas Kazimi","startTime":2085.485,"endTime":2089.165,"body":"the conversation becomes Let's"},{"speaker":"Abbas Kazimi","startTime":2085.485,"endTime":2089.165,"body":"weigh the pros and cons. And"},{"speaker":"Abbas Kazimi","startTime":2087.149,"endTime":2094.818,"body":"so when you go to the pharma"},{"speaker":"Abbas Kazimi","startTime":2087.149,"endTime":2094.818,"body":"partners, and they have the"},{"speaker":"Abbas Kazimi","startTime":2089.227,"endTime":2092.969,"body":"every board meeting ends with"},{"speaker":"Abbas Kazimi","startTime":2089.227,"endTime":2092.969,"body":"the same conversation of great"},{"speaker":"Abbas Kazimi","startTime":2093.032,"endTime":2096.774,"body":"job, continue creating more"},{"speaker":"Abbas Kazimi","startTime":2093.032,"endTime":2096.774,"body":"options. And I love that. I love"},{"speaker":"Abbas Kazimi","startTime":2094.954,"endTime":2103.581,"body":"exemplars in their mind that you"},{"speaker":"Abbas Kazimi","startTime":2094.954,"endTime":2103.581,"body":"were the first company to have"},{"speaker":"Abbas Kazimi","startTime":2096.836,"endTime":2099.02,"body":"that curiosity side of the picture."},{"speaker":"Unknown","startTime":2099.0,"endTime":2327.705,"body":"the world,  as you see"},{"speaker":"Unknown","startTime":2099.0,"endTime":2327.705,"body":"it?"},{"speaker":"Unknown","startTime":2103.718,"endTime":2110.976,"body":"in the immuno oncology space,"},{"speaker":"Unknown","startTime":2103.718,"endTime":2110.976,"body":"the most selective HPK1"},{"speaker":"Unknown","startTime":2111.113,"endTime":2119.739,"body":"inhibitor in the clinic, you're"},{"speaker":"Unknown","startTime":2111.113,"endTime":2119.739,"body":"seeing responses. You were able"},{"speaker":"Unknown","startTime":2119.876,"endTime":2127.408,"body":"to actually get the most"},{"speaker":"Unknown","startTime":2119.876,"endTime":2127.408,"body":"selective TYK2 inhibitor going"},{"speaker":"Unknown","startTime":2127.545,"endTime":2135.487,"body":"after allosteric pockets, the"},{"speaker":"Unknown","startTime":2127.545,"endTime":2135.487,"body":"way Bristol did, but clearly"},{"speaker":"Unknown","startTime":2135.624,"endTime":2143.429,"body":"with more selectivity, which"},{"speaker":"Unknown","startTime":2135.624,"endTime":2143.429,"body":"translated to more efficacy,"},{"speaker":"Unknown","startTime":2143.566,"endTime":2151.508,"body":"which is why Takeda bought it."},{"speaker":"Unknown","startTime":2143.566,"endTime":2151.508,"body":"You're able to get a Werner"},{"speaker":"Unknown","startTime":2151.645,"endTime":2159.861,"body":"program to go after a helicase"},{"speaker":"Unknown","startTime":2151.645,"endTime":2159.861,"body":"that's turning over every six"},{"speaker":"Unknown","startTime":2159.998,"endTime":2167.803,"body":"hours, but to suppress that"},{"speaker":"Unknown","startTime":2159.998,"endTime":2167.803,"body":"helicase in patients with MSI"},{"speaker":"Unknown","startTime":2167.94,"endTime":2176.019,"body":"high tumors, to shut down that"},{"speaker":"Unknown","startTime":2167.94,"endTime":2176.019,"body":"helicase to drive cell death"},{"speaker":"Unknown","startTime":2176.156,"endTime":2184.92,"body":"with the selectivity that Nimbus"},{"speaker":"Unknown","startTime":2176.156,"endTime":2184.92,"body":"has with its platform,. You did"},{"speaker":"Unknown","startTime":2185.057,"endTime":2192.999,"body":"that, and now with SIK2, we're"},{"speaker":"Unknown","startTime":2185.057,"endTime":2192.999,"body":"on the path to nominate our"},{"speaker":"Unknown","startTime":2193.136,"endTime":2201.489,"body":"clinical candidate by the end of"},{"speaker":"Unknown","startTime":2193.136,"endTime":2201.489,"body":"the year, and first in human"},{"speaker":"Unknown","startTime":2201.626,"endTime":2210.526,"body":"next year. It just shows that we"},{"speaker":"Unknown","startTime":2201.626,"endTime":2210.526,"body":"have this belief that we can use"},{"speaker":"Unknown","startTime":2210.663,"endTime":2219.016,"body":"our computational tools with our"},{"speaker":"Unknown","startTime":2210.663,"endTime":2219.016,"body":"partners outside of our four"},{"speaker":"Unknown","startTime":2219.153,"endTime":2226.274,"body":"walls to really offer a"},{"speaker":"Unknown","startTime":2219.153,"endTime":2226.274,"body":"transformative new mechanism"},{"speaker":"Unknown","startTime":2226.411,"endTime":2233.942,"body":"that's applicable across"},{"speaker":"Unknown","startTime":2226.411,"endTime":2233.942,"body":"multiple inflammatory diseases"},{"speaker":"Unknown","startTime":2234.079,"endTime":2242.843,"body":"where steroid-sparing, cytokine"},{"speaker":"Unknown","startTime":2234.079,"endTime":2242.843,"body":"-targeted approaches are falling"},{"speaker":"Unknown","startTime":2242.98,"endTime":2250.785,"body":"short in our mind. So that, I"},{"speaker":"Unknown","startTime":2242.98,"endTime":2250.785,"body":"think, is a nutshell of how"},{"speaker":"Unknown","startTime":2250.922,"endTime":2259.275,"body":"Nimbus is able to do it, select"},{"speaker":"Unknown","startTime":2250.922,"endTime":2259.275,"body":"a target, work with the right"},{"speaker":"Unknown","startTime":2259.412,"endTime":2267.491,"body":"collaborator, bring on the right"},{"speaker":"Unknown","startTime":2259.412,"endTime":2267.491,"body":"tools from either academic"},{"speaker":"Unknown","startTime":2267.628,"endTime":2274.748,"body":"institutions or established"},{"speaker":"Unknown","startTime":2267.628,"endTime":2274.748,"body":"partners like Cresset or"},{"speaker":"Unknown","startTime":2274.885,"endTime":2283.786,"body":"Schrodinger or Proteros to get a"},{"speaker":"Unknown","startTime":2274.885,"endTime":2283.786,"body":"structure, and we just have this"},{"speaker":"Unknown","startTime":2283.923,"endTime":2292.55,"body":"ability to kind of bring on the"},{"speaker":"Unknown","startTime":2283.923,"endTime":2292.55,"body":"best of minds at the right time"},{"speaker":"Unknown","startTime":2292.687,"endTime":2301.313,"body":"and uniquely position our lead"},{"speaker":"Unknown","startTime":2292.687,"endTime":2301.313,"body":"based on our chemistry strength,"},{"speaker":"Unknown","startTime":2301.45,"endTime":2310.077,"body":"our strength, our deep target,"},{"speaker":"Unknown","startTime":2301.45,"endTime":2310.077,"body":"conviction and a track record of"},{"speaker":"Unknown","startTime":2310.214,"endTime":2318.704,"body":"just building real drugs that,"},{"speaker":"Unknown","startTime":2310.214,"endTime":2318.704,"body":"for me, is a formulation that I"},{"speaker":"Unknown","startTime":2318.841,"endTime":2326.783,"body":"don't hear too often, that in"},{"speaker":"Unknown","startTime":2318.841,"endTime":2326.783,"body":"two minutes, are you able to"},{"speaker":"Unknown","startTime":2326.92,"endTime":2334.588,"body":"summarize a virtual platform, a"},{"speaker":"Unknown","startTime":2326.92,"endTime":2334.588,"body":"technology platform, and"},{"speaker":"Unknown","startTime":2334.725,"endTime":2343.352,"body":"highlight a drug that is going"},{"speaker":"Unknown","startTime":2334.725,"endTime":2343.352,"body":"to be transformative? That's why"},{"speaker":"Unknown","startTime":2343.489,"endTime":2351.568,"body":"I stuck around for this many"},{"speaker":"Unknown","startTime":2343.489,"endTime":2351.568,"body":"years. John, I think it's very"},{"speaker":"Unknown","startTime":2350.565,"endTime":2373.29,"body":"I think about that from two"},{"speaker":"Unknown","startTime":2350.565,"endTime":2373.29,"body":"lenses, the word you stuck out"},{"speaker":"Unknown","startTime":2351.705,"endTime":2360.058,"body":"unique of what Nimbus has been"},{"speaker":"Unknown","startTime":2351.705,"endTime":2360.058,"body":"doing and what it's continuing"},{"speaker":"Unknown","startTime":2360.195,"endTime":2360.88,"body":"to do"},{"speaker":"Unknown","startTime":2373.29,"endTime":2377.31,"body":"in there, what good you can do"},{"speaker":"Unknown","startTime":2373.29,"endTime":2377.31,"body":"in the world and what Nimbus can"},{"speaker":"Unknown","startTime":2377.31,"endTime":2382.11,"body":"do. So the first part, if Nimbus"},{"speaker":"Unknown","startTime":2377.31,"endTime":2382.11,"body":"succeeds the way I hope it will."},{"speaker":"Unknown","startTime":2382.77,"endTime":2386.55,"body":"Will have brought life changing"},{"speaker":"Unknown","startTime":2382.77,"endTime":2386.55,"body":"medicines to people who are sick"},{"speaker":"Unknown","startTime":2386.73,"endTime":2389.67,"body":"and out of options, and that's"},{"speaker":"Unknown","startTime":2386.73,"endTime":2389.67,"body":"the most important thing. We"},{"speaker":"Unknown","startTime":2389.67,"endTime":2393.75,"body":"will have made science matter"},{"speaker":"Unknown","startTime":2389.67,"endTime":2393.75,"body":"the most human way possible. But"},{"speaker":"Unknown","startTime":2393.75,"endTime":2398.475,"body":"beyond that, what I do hope is"},{"speaker":"Unknown","startTime":2393.75,"endTime":2398.475,"body":"that we show what's possible in"},{"speaker":"Unknown","startTime":2398.475,"endTime":2402.915,"body":"biotech. That we can build a"},{"speaker":"Unknown","startTime":2398.475,"endTime":2402.915,"body":"company that's fast, rigorous,"},{"speaker":"Unknown","startTime":2403.155,"endTime":2406.695,"body":"but rooted in purpose. That you"},{"speaker":"Unknown","startTime":2403.155,"endTime":2406.695,"body":"can scale without losing your"},{"speaker":"Unknown","startTime":2406.695,"endTime":2410.295,"body":"soul. That culture, creativity"},{"speaker":"Unknown","startTime":2406.695,"endTime":2410.295,"body":"and compassion are competitive"},{"speaker":"Unknown","startTime":2410.295,"endTime":2414.255,"body":"advantages and not just"},{"speaker":"Unknown","startTime":2410.295,"endTime":2414.255,"body":"feel-good values. And if we do"},{"speaker":"Unknown","startTime":2414.255,"endTime":2417.255,"body":"it right, we'll not only help"},{"speaker":"Unknown","startTime":2414.255,"endTime":2417.255,"body":"patients, we'll also help shape"},{"speaker":"Unknown","startTime":2417.255,"endTime":2420.66,"body":"the next generation of leaders"},{"speaker":"Unknown","startTime":2417.255,"endTime":2420.66,"body":"and companies. The ripple effect"},{"speaker":"Unknown","startTime":2421.56,"endTime":2425.76,"body":"that I see that we get calls all"},{"speaker":"Unknown","startTime":2421.56,"endTime":2425.76,"body":"the time about, can you talk to"},{"speaker":"Unknown","startTime":2425.76,"endTime":2429.6,"body":"this investment that I've made?"},{"speaker":"Unknown","startTime":2425.76,"endTime":2429.6,"body":"They want to emulate Nimbus."},{"speaker":"Unknown","startTime":2429.96,"endTime":2432.78,"body":"They want to have the same"},{"speaker":"Unknown","startTime":2429.96,"endTime":2432.78,"body":"business model. They want to"},{"speaker":"Unknown","startTime":2432.78,"endTime":2436.98,"body":"have the same principles. And"},{"speaker":"Unknown","startTime":2432.78,"endTime":2436.98,"body":"that is great. I love that. I"},{"speaker":"Unknown","startTime":2436.98,"endTime":2439.92,"body":"love being able to talk about"},{"speaker":"Unknown","startTime":2436.98,"endTime":2439.92,"body":"how we've done it, why we're"},{"speaker":"Unknown","startTime":2439.92,"endTime":2443.28,"body":"doing it. And that kind of good"},{"speaker":"Unknown","startTime":2439.92,"endTime":2443.28,"body":"is what I want to leave behind"},{"speaker":"Unknown","startTime":2443.625,"endTime":2450.285,"body":"as an organization on what good"},{"speaker":"Unknown","startTime":2443.625,"endTime":2450.285,"body":"we could do in the world. Kind"},{"speaker":"Unknown","startTime":2450.285,"endTime":2454.485,"body":"of goes back to how we were"},{"speaker":"Unknown","startTime":2450.285,"endTime":2454.485,"body":"raised. My wife and I have a"},{"speaker":"Unknown","startTime":2454.485,"endTime":2459.045,"body":"very similar upbringing, being"},{"speaker":"Unknown","startTime":2454.485,"endTime":2459.045,"body":"fortunate to travel the world,"},{"speaker":"Unknown","startTime":2459.705,"endTime":2464.745,"body":"to see the world as its flat, to"},{"speaker":"Unknown","startTime":2459.705,"endTime":2464.745,"body":"see the world in terms of"},{"speaker":"Unknown","startTime":2465.15,"endTime":2470.25,"body":"anything as accessible, but yet"},{"speaker":"Unknown","startTime":2465.15,"endTime":2470.25,"body":"humbling ourselves on how how"},{"speaker":"Unknown","startTime":2470.25,"endTime":2474.39,"body":"much disparity there also is in"},{"speaker":"Unknown","startTime":2470.25,"endTime":2474.39,"body":"the world. And so knowing that"},{"speaker":"Unknown","startTime":2474.39,"endTime":2477.51,"body":"we've worked hard, knowing that"},{"speaker":"Unknown","startTime":2474.39,"endTime":2477.51,"body":"we will continue working hard"},{"speaker":"Unknown","startTime":2477.51,"endTime":2481.95,"body":"for a greater purpose, we also"},{"speaker":"Unknown","startTime":2477.51,"endTime":2481.95,"body":"have been very fortunate in this"},{"speaker":"Unknown","startTime":2481.95,"endTime":2485.43,"body":"industry to be able to give"},{"speaker":"Unknown","startTime":2481.95,"endTime":2485.43,"body":"back. And so we are giving back"},{"speaker":"Unknown","startTime":2485.43,"endTime":2488.85,"body":"on two levels, one on the"},{"speaker":"Unknown","startTime":2485.43,"endTime":2488.85,"body":"research side. I think that was"},{"speaker":"Unknown","startTime":2488.895,"endTime":2492.855,"body":"important for me, knowing that"},{"speaker":"Unknown","startTime":2488.895,"endTime":2492.855,"body":"my mother, who continues to be"},{"speaker":"Unknown","startTime":2492.855,"endTime":2495.915,"body":"treated at MD Anderson, my"},{"speaker":"Unknown","startTime":2492.855,"endTime":2495.915,"body":"sibling as well, and my father"},{"speaker":"Unknown","startTime":2495.915,"endTime":2499.335,"body":"who was treated before he passed"},{"speaker":"Unknown","startTime":2495.915,"endTime":2499.335,"body":"away, to MD Anderson, we"},{"speaker":"Unknown","startTime":2499.335,"endTime":2504.555,"body":"established an endowment at this"},{"speaker":"Unknown","startTime":2499.335,"endTime":2504.555,"body":"integrated data sciences group"},{"speaker":"Unknown","startTime":2504.795,"endTime":2508.335,"body":"within MD Anderson. It spoke to"},{"speaker":"Unknown","startTime":2504.795,"endTime":2508.335,"body":"both of what we do for a living,"},{"speaker":"Unknown","startTime":2508.635,"endTime":2511.276,"body":"a lot of data sciences within"},{"speaker":"Unknown","startTime":2508.635,"endTime":2511.276,"body":"oncology, and being able to take"},{"speaker":"Unknown","startTime":2511.276,"endTime":2511.47,"body":"some of the computational"},{"speaker":"Unknown","startTime":2511.276,"endTime":2511.47,"body":"background I've built and"},{"speaker":"Unknown","startTime":2511.47,"endTime":2511.737,"body":"learned about at Nimbus, knowing"},{"speaker":"Unknown","startTime":2511.47,"endTime":2511.737,"body":"that MD Anderson is doing that"},{"speaker":"Unknown","startTime":2511.737,"endTime":2511.956,"body":"to serve patients. So giving"},{"speaker":"Unknown","startTime":2511.737,"endTime":2511.956,"body":"back from an endowment"},{"speaker":"Unknown","startTime":2511.956,"endTime":2518.46,"body":"perspective, especially in an"},{"speaker":"Unknown","startTime":2511.956,"endTime":2518.46,"body":"environment where academics and"},{"speaker":"Unknown","startTime":2519.18,"endTime":2525.0,"body":"human academics and universities"},{"speaker":"Unknown","startTime":2519.18,"endTime":2525.0,"body":"are being attacked, we were"},{"speaker":"Unknown","startTime":2525.0,"endTime":2528.06,"body":"really excited to be able to"},{"speaker":"Unknown","startTime":2525.0,"endTime":2528.06,"body":"support their mission and make a"},{"speaker":"Unknown","startTime":2528.06,"endTime":2532.26,"body":"difference. And then more on a"},{"speaker":"Unknown","startTime":2528.06,"endTime":2532.26,"body":"local level, just giving back to"},{"speaker":"Unknown","startTime":2532.26,"endTime":2536.385,"body":"the community. We've been really"},{"speaker":"Unknown","startTime":2532.26,"endTime":2536.385,"body":"active with CASPAR homeless"},{"speaker":"Unknown","startTime":2536.385,"endTime":2541.425,"body":"shelter out here in Cambridge,"},{"speaker":"Unknown","startTime":2536.385,"endTime":2541.425,"body":"and by chance, we had a chance"},{"speaker":"Unknown","startTime":2541.425,"endTime":2545.025,"body":"to meet them a couple of years"},{"speaker":"Unknown","startTime":2541.425,"endTime":2545.025,"body":"ago in Cambridge. They were"},{"speaker":"Unknown","startTime":2545.025,"endTime":2548.625,"body":"situated right behind MIT, and"},{"speaker":"Unknown","startTime":2545.025,"endTime":2548.625,"body":"they're still there. But for me,"},{"speaker":"Unknown","startTime":2548.625,"endTime":2552.465,"body":"it's all of it. I know science"},{"speaker":"Unknown","startTime":2548.625,"endTime":2552.465,"body":"and medicines are important, but"},{"speaker":"Unknown","startTime":2552.465,"endTime":2555.825,"body":"ultimately the humanity of it"},{"speaker":"Unknown","startTime":2552.465,"endTime":2555.825,"body":"all matters as well, and so"},{"speaker":"Unknown","startTime":2555.825,"endTime":2558.99,"body":"being able to support local"},{"speaker":"Unknown","startTime":2555.825,"endTime":2558.99,"body":"causes of where we're from in"},{"speaker":"Unknown","startTime":2558.99,"endTime":2561.87,"body":"our community, people with"},{"speaker":"Unknown","startTime":2558.99,"endTime":2561.87,"body":"addiction, people who are"},{"speaker":"Unknown","startTime":2561.87,"endTime":2565.83,"body":"homeless, I think it's important"},{"speaker":"Unknown","startTime":2561.87,"endTime":2565.83,"body":"that we don't lose ourselves in"},{"speaker":"Unknown","startTime":2565.83,"endTime":2568.41,"body":"just about the headlines on"},{"speaker":"Unknown","startTime":2565.83,"endTime":2568.41,"body":"what's the next big deal going"},{"speaker":"Unknown","startTime":2568.41,"endTime":2572.97,"body":"to look like. This idea of being"},{"speaker":"Unknown","startTime":2568.41,"endTime":2572.97,"body":"altruistic in your work, but"},{"speaker":"Unknown","startTime":2573.27,"endTime":2576.51,"body":"being altruistic in your"},{"speaker":"Unknown","startTime":2573.27,"endTime":2576.51,"body":"community. For me, that's just"},{"speaker":"Unknown","startTime":2576.51,"endTime":2581.715,"body":"so important. So my ambition is"},{"speaker":"Unknown","startTime":2576.51,"endTime":2581.715,"body":"to never lose sight of that."},{"speaker":"Unknown","startTime":2581.955,"endTime":2585.915,"body":"Never lose sight of being"},{"speaker":"Unknown","startTime":2581.955,"endTime":2585.915,"body":"grounded with humility and being"},{"speaker":"Unknown","startTime":2585.915,"endTime":2589.515,"body":"grounded by gratitude. And so if"},{"speaker":"Unknown","startTime":2585.915,"endTime":2589.515,"body":"Nimbus can allow us to achieve"},{"speaker":"Unknown","startTime":2589.515,"endTime":2593.655,"body":"that by the organization, being"},{"speaker":"Unknown","startTime":2589.515,"endTime":2593.655,"body":"grounded in gratitude and"},{"speaker":"Unknown","startTime":2593.655,"endTime":2597.135,"body":"humility, I think as"},{"speaker":"Unknown","startTime":2593.655,"endTime":2597.135,"body":"individuals, inevitably, we'll"},{"speaker":"Unknown","startTime":2597.135,"endTime":2598.515,"body":"have that spillover effect."},{"speaker":"John Simboli","startTime":2599.775,"endTime":2601.815,"body":"Abbas, thank you"},{"speaker":"John Simboli","startTime":2599.775,"endTime":2601.815,"body":"for speaking with me today."},{"speaker":"Unknown","startTime":2602.1,"endTime":2604.74,"body":"My pleasure. Our"},{"speaker":"Unknown","startTime":2602.1,"endTime":2604.74,"body":"mission is to serve patients and"},{"speaker":"Unknown","startTime":2604.74,"endTime":2608.52,"body":"to make medicines and"},{"speaker":"Unknown","startTime":2604.74,"endTime":2608.52,"body":"leadership. Will have to"},{"speaker":"Unknown","startTime":2608.52,"endTime":2612.24,"body":"navigate through all the"},{"speaker":"Unknown","startTime":2608.52,"endTime":2612.24,"body":"inevitable questions of what may"},{"speaker":"Unknown","startTime":2612.24,"endTime":2616.02,"body":"or may not happen, but yet"},{"speaker":"Unknown","startTime":2612.24,"endTime":2616.02,"body":"manage risk with a deep, deep"},{"speaker":"Unknown","startTime":2616.02,"endTime":2617.34,"body":"purpose to serve others."}]}