{"version":"1.0.0","segments":[{"speaker":"John Simboli","startTime":0.0,"endTime":2.04,"body":"as CEO of Citryll?"},{"speaker":"Eduardo Bravo","startTime":2.52,"endTime":4.56,"body":"Thank you, John."},{"speaker":"Eduardo Bravo","startTime":2.52,"endTime":4.56,"body":"Thank you very much for inviting"},{"speaker":"Eduardo Bravo","startTime":4.56,"endTime":4.68,"body":"me."},{"speaker":"John Simboli","startTime":4.98,"endTime":7.98,"body":"What led you to"},{"speaker":"John Simboli","startTime":4.98,"endTime":7.98,"body":"your role as CEO of Citryll?"},{"speaker":"Eduardo Bravo","startTime":8.86,"endTime":14.32,"body":"I did many years"},{"speaker":"Eduardo Bravo","startTime":8.86,"endTime":14.32,"body":"of Big Pharma, and then I had a"},{"speaker":"Eduardo Bravo","startTime":14.38,"endTime":19.96,"body":"very large job as the CEO of a"},{"speaker":"Eduardo Bravo","startTime":14.38,"endTime":19.96,"body":"biotech that started in Spain"},{"speaker":"Eduardo Bravo","startTime":19.96,"endTime":23.2,"body":"and then moved to Belgium. I"},{"speaker":"Eduardo Bravo","startTime":19.96,"endTime":23.2,"body":"moved to the dark side for a"},{"speaker":"Eduardo Bravo","startTime":23.2,"endTime":26.92,"body":"couple of years, where I was the"},{"speaker":"Eduardo Bravo","startTime":23.2,"endTime":26.92,"body":"operational partner of a SPAC"},{"speaker":"Eduardo Bravo","startTime":26.98,"endTime":31.645,"body":"out of of LSP, then EQT. And"},{"speaker":"Eduardo Bravo","startTime":26.98,"endTime":31.645,"body":"when we finished that, and we,"},{"speaker":"Eduardo Bravo","startTime":31.645,"endTime":34.465,"body":"you know, reverse merged into"},{"speaker":"Eduardo Bravo","startTime":31.645,"endTime":34.465,"body":"Oculus, which is a fantastic"},{"speaker":"Eduardo Bravo","startTime":34.465,"endTime":38.425,"body":"company now quoted in NASDAQ. I"},{"speaker":"Eduardo Bravo","startTime":34.465,"endTime":38.425,"body":"just, you know, had this"},{"speaker":"Eduardo Bravo","startTime":38.425,"endTime":40.705,"body":"conversation internally and"},{"speaker":"Eduardo Bravo","startTime":38.425,"endTime":40.705,"body":"said, like, you know, I have the"},{"speaker":"Eduardo Bravo","startTime":40.705,"endTime":44.065,"body":"energy to do another one. And"},{"speaker":"Eduardo Bravo","startTime":40.705,"endTime":44.065,"body":"what I missed over those two"},{"speaker":"Eduardo Bravo","startTime":44.065,"endTime":49.105,"body":"years in at EBAC was the day to"},{"speaker":"Eduardo Bravo","startTime":44.065,"endTime":49.105,"body":"day adrenaline, as I call it."},{"speaker":"Eduardo Bravo","startTime":49.405,"endTime":54.07,"body":"And then, you know, started"},{"speaker":"Eduardo Bravo","startTime":49.405,"endTime":54.07,"body":"looking. Fairly quickly, you"},{"speaker":"Eduardo Bravo","startTime":54.07,"endTime":57.31,"body":"know, Citryll came to my"},{"speaker":"Eduardo Bravo","startTime":54.07,"endTime":57.31,"body":"attention through one of the"},{"speaker":"Eduardo Bravo","startTime":57.37,"endTime":60.43,"body":"board members, Daniela Couto,"},{"speaker":"Eduardo Bravo","startTime":57.37,"endTime":60.43,"body":"and I started exploring the"},{"speaker":"Eduardo Bravo","startTime":60.43,"endTime":63.31,"body":"company. Two years later, here"},{"speaker":"Eduardo Bravo","startTime":60.43,"endTime":63.31,"body":"am I."},{"speaker":"John Simboli","startTime":63.49,"endTime":64.87,"body":"During the"},{"speaker":"John Simboli","startTime":63.49,"endTime":64.87,"body":"exploration. What were the"},{"speaker":"John Simboli","startTime":64.87,"endTime":68.23,"body":"factors that made that stand out"},{"speaker":"John Simboli","startTime":64.87,"endTime":68.23,"body":"related to all the other ones"},{"speaker":"John Simboli","startTime":68.23,"endTime":68.95,"body":"you were looking at?"},{"speaker":"Eduardo Bravo","startTime":69.02,"endTime":72.08,"body":"The disadvantage,"},{"speaker":"Eduardo Bravo","startTime":69.02,"endTime":72.08,"body":"hopefully, for this, an"},{"speaker":"Eduardo Bravo","startTime":72.08,"endTime":75.68,"body":"advantage, of not having a"},{"speaker":"Eduardo Bravo","startTime":72.08,"endTime":75.68,"body":"scientific background is that I"},{"speaker":"Eduardo Bravo","startTime":75.68,"endTime":79.16,"body":"was relying on, actually, the"},{"speaker":"Eduardo Bravo","startTime":75.68,"endTime":79.16,"body":"scientific due diligence having"},{"speaker":"Eduardo Bravo","startTime":79.16,"endTime":83.66,"body":"been done by other people. But"},{"speaker":"Eduardo Bravo","startTime":79.16,"endTime":83.66,"body":"you know, when you look at most"},{"speaker":"Eduardo Bravo","startTime":83.66,"endTime":87.44,"body":"of the companies that I was"},{"speaker":"Eduardo Bravo","startTime":83.66,"endTime":87.44,"body":"looking at, all were backed by"},{"speaker":"Eduardo Bravo","startTime":87.44,"endTime":91.52,"body":"very well known VCs. So you"},{"speaker":"Eduardo Bravo","startTime":87.44,"endTime":91.52,"body":"know, I don't think that there's"},{"speaker":"Eduardo Bravo","startTime":91.52,"endTime":94.385,"body":"anything that I was going to"},{"speaker":"Eduardo Bravo","startTime":91.52,"endTime":94.385,"body":"discover on my due diligence"},{"speaker":"Eduardo Bravo","startTime":94.385,"endTime":99.965,"body":"that had not been discovered by"},{"speaker":"Eduardo Bravo","startTime":94.385,"endTime":99.965,"body":"the VCs. If they were happy to"},{"speaker":"Eduardo Bravo","startTime":99.965,"endTime":102.725,"body":"invest and continue to fund the"},{"speaker":"Eduardo Bravo","startTime":99.965,"endTime":102.725,"body":"company, meant that at least"},{"speaker":"Eduardo Bravo","startTime":102.725,"endTime":105.305,"body":"they believe what they were"},{"speaker":"Eduardo Bravo","startTime":102.725,"endTime":105.305,"body":"doing. So for me, the scientific"},{"speaker":"Eduardo Bravo","startTime":105.725,"endTime":112.505,"body":"tick is done by third parties,"},{"speaker":"Eduardo Bravo","startTime":105.725,"endTime":112.505,"body":"if I may say so. Then for me,"},{"speaker":"Eduardo Bravo","startTime":112.505,"endTime":118.91,"body":"what made Citryll a very special"},{"speaker":"Eduardo Bravo","startTime":112.505,"endTime":118.91,"body":"case was, one, despite lack of"},{"speaker":"Eduardo Bravo","startTime":118.91,"endTime":122.99,"body":"scientific knowledge, the"},{"speaker":"Eduardo Bravo","startTime":118.91,"endTime":122.99,"body":"science was super easy to"},{"speaker":"Eduardo Bravo","startTime":122.99,"endTime":127.31,"body":"understand. It's almost, you"},{"speaker":"Eduardo Bravo","startTime":122.99,"endTime":127.31,"body":"know, pretty intuitive, provided"},{"speaker":"Eduardo Bravo","startTime":127.31,"endTime":130.25,"body":"you believe, in all the"},{"speaker":"Eduardo Bravo","startTime":127.31,"endTime":130.25,"body":"mechanisms that go afterwards."},{"speaker":"Eduardo Bravo","startTime":130.25,"endTime":135.17,"body":"But, you know, the idea is a"},{"speaker":"Eduardo Bravo","startTime":130.25,"endTime":135.17,"body":"super simple idea, and it was"},{"speaker":"Eduardo Bravo","startTime":135.47,"endTime":139.295,"body":"very novel. I mean, it's first"},{"speaker":"Eduardo Bravo","startTime":135.47,"endTime":139.295,"body":"in class. No one has ever been"},{"speaker":"Eduardo Bravo","startTime":139.295,"endTime":144.155,"body":"able to target these NETs. And,"},{"speaker":"Eduardo Bravo","startTime":139.295,"endTime":144.155,"body":"you know, this can have such an"},{"speaker":"Eduardo Bravo","startTime":144.155,"endTime":147.395,"body":"influence on such a number of"},{"speaker":"Eduardo Bravo","startTime":144.155,"endTime":147.395,"body":"diseases, that I thought like,"},{"speaker":"Eduardo Bravo","startTime":147.395,"endTime":151.595,"body":"you know, I spent 13 years"},{"speaker":"Eduardo Bravo","startTime":147.395,"endTime":151.595,"body":"developing something that was"},{"speaker":"Eduardo Bravo","startTime":151.595,"endTime":156.035,"body":"super strange and rare for a"},{"speaker":"Eduardo Bravo","startTime":151.595,"endTime":156.035,"body":"very minor disease, and that"},{"speaker":"Eduardo Bravo","startTime":157.175,"endTime":160.46,"body":"gives another satisfaction. That"},{"speaker":"Eduardo Bravo","startTime":157.175,"endTime":160.46,"body":"product made it to the market."},{"speaker":"Eduardo Bravo","startTime":160.46,"endTime":165.02,"body":"So we we did that. Now I was"},{"speaker":"Eduardo Bravo","startTime":160.46,"endTime":165.02,"body":"like, Wow, this drug can change"},{"speaker":"Eduardo Bravo","startTime":165.02,"endTime":168.14,"body":"the industry. That's how I see"},{"speaker":"Eduardo Bravo","startTime":165.02,"endTime":168.14,"body":"it. And I said, Well, this is"},{"speaker":"Eduardo Bravo","startTime":168.14,"endTime":171.38,"body":"the sort of, if I'm going to"},{"speaker":"Eduardo Bravo","startTime":168.14,"endTime":171.38,"body":"devote five years of my energy"},{"speaker":"Eduardo Bravo","startTime":171.38,"endTime":173.9,"body":"into something, I want it to be"},{"speaker":"Eduardo Bravo","startTime":171.38,"endTime":173.9,"body":"as meaningful as that."},{"speaker":"John Simboli","startTime":174.2,"endTime":176.78,"body":"For a few CEOs"},{"speaker":"John Simboli","startTime":174.2,"endTime":176.78,"body":"I've spoken with, I've heard"},{"speaker":"John Simboli","startTime":176.78,"endTime":179.72,"body":"this variation, \"Yeah, I thought"},{"speaker":"John Simboli","startTime":176.78,"endTime":179.72,"body":"about it long and hard and"},{"speaker":"John Simboli","startTime":179.72,"endTime":182.78,"body":"decided this was what I wanted"},{"speaker":"John Simboli","startTime":179.72,"endTime":182.78,"body":"to do.\" There's a pause, \"And"},{"speaker":"John Simboli","startTime":182.78,"endTime":186.365,"body":"then I spoke to my family.\" So"},{"speaker":"John Simboli","startTime":182.78,"endTime":186.365,"body":"that is my question, what did"},{"speaker":"John Simboli","startTime":186.365,"endTime":188.225,"body":"your loved ones think of this"},{"speaker":"John Simboli","startTime":186.365,"endTime":188.225,"body":"idea?"},{"speaker":"Eduardo Bravo","startTime":188.0,"endTime":190.28,"body":"That I was"},{"speaker":"Eduardo Bravo","startTime":188.0,"endTime":190.28,"body":"completely crazy and that I"},{"speaker":"Eduardo Bravo","startTime":190.28,"endTime":194.6,"body":"should not do it. And, you know,"},{"speaker":"Eduardo Bravo","startTime":190.28,"endTime":194.6,"body":"I was 40 when I left. I was, you"},{"speaker":"Eduardo Bravo","startTime":194.6,"endTime":197.12,"body":"know, Vice President of the"},{"speaker":"Eduardo Bravo","startTime":194.6,"endTime":197.12,"body":"whole of Latin America. Probably"},{"speaker":"Eduardo Bravo","startTime":197.12,"endTime":200.48,"body":"as the youngest vice president"},{"speaker":"Eduardo Bravo","startTime":197.12,"endTime":200.48,"body":"at Sanofi-Aventis at that time."},{"speaker":"Eduardo Bravo","startTime":201.02,"endTime":204.38,"body":"Very well regarded, and I was"},{"speaker":"Eduardo Bravo","startTime":201.02,"endTime":204.38,"body":"joining an 18 people team in"},{"speaker":"Eduardo Bravo","startTime":204.38,"endTime":208.46,"body":"Spain in cell therapy. I mean,"},{"speaker":"Eduardo Bravo","startTime":204.38,"endTime":208.46,"body":"it was like, What on earth are"},{"speaker":"Eduardo Bravo","startTime":208.46,"endTime":212.225,"body":"you doing? But you know what?"},{"speaker":"Eduardo Bravo","startTime":208.46,"endTime":212.225,"body":"Really, I wanted to be calling"},{"speaker":"Eduardo Bravo","startTime":212.225,"endTime":216.905,"body":"the shots, and I wanted to run a"},{"speaker":"Eduardo Bravo","startTime":212.225,"endTime":216.905,"body":"company my way, which I had the"},{"speaker":"Eduardo Bravo","startTime":216.905,"endTime":219.965,"body":"opportunity of doing with"},{"speaker":"Eduardo Bravo","startTime":216.905,"endTime":219.965,"body":"divisions in the past, but not"},{"speaker":"Eduardo Bravo","startTime":220.385,"endTime":224.285,"body":"at the time of making the"},{"speaker":"Eduardo Bravo","startTime":220.385,"endTime":224.285,"body":"decisions. You look that you are"},{"speaker":"Eduardo Bravo","startTime":224.285,"endTime":227.765,"body":"very young, but still, you know,"},{"speaker":"Eduardo Bravo","startTime":224.285,"endTime":227.765,"body":"only 20-25, years ahead of you."},{"speaker":"Eduardo Bravo","startTime":227.765,"endTime":230.285,"body":"So, you know, staying longer,"},{"speaker":"Eduardo Bravo","startTime":227.765,"endTime":230.285,"body":"then it would have been"},{"speaker":"Eduardo Bravo","startTime":230.285,"endTime":233.645,"body":"impossible to move. And then"},{"speaker":"Eduardo Bravo","startTime":230.285,"endTime":233.645,"body":"some people have done it, so"},{"speaker":"Eduardo Bravo","startTime":233.645,"endTime":235.67,"body":"probably it was the wrong"},{"speaker":"Eduardo Bravo","startTime":233.645,"endTime":235.67,"body":"assumption. But I thought like,"},{"speaker":"Eduardo Bravo","startTime":235.67,"endTime":239.57,"body":"you know, come on, I'm young, I"},{"speaker":"Eduardo Bravo","startTime":235.67,"endTime":239.57,"body":"have the opportunity. Let's"},{"speaker":"Eduardo Bravo","startTime":239.57,"endTime":243.05,"body":"jump, and you can always go"},{"speaker":"Eduardo Bravo","startTime":239.57,"endTime":243.05,"body":"back. It was much tougher than"},{"speaker":"Eduardo Bravo","startTime":243.05,"endTime":247.01,"body":"what I anticipated. So let's,"},{"speaker":"Eduardo Bravo","startTime":243.05,"endTime":247.01,"body":"let's be realistic here. I think"},{"speaker":"Eduardo Bravo","startTime":247.01,"endTime":250.67,"body":"that, you know, there's all the"},{"speaker":"Eduardo Bravo","startTime":247.01,"endTime":250.67,"body":"glamor of the things that I was"},{"speaker":"Eduardo Bravo","startTime":250.67,"endTime":254.63,"body":"looking for was great, but, you"},{"speaker":"Eduardo Bravo","startTime":250.67,"endTime":254.63,"body":"know, it's also very challenging"},{"speaker":"Eduardo Bravo","startTime":254.63,"endTime":256.91,"body":"when you don't have the"},{"speaker":"Eduardo Bravo","startTime":254.63,"endTime":256.91,"body":"resources that you're used to"},{"speaker":"Eduardo Bravo","startTime":256.91,"endTime":261.035,"body":"having and you deal with a very,"},{"speaker":"Eduardo Bravo","startTime":256.91,"endTime":261.035,"body":"very small team. You know,"},{"speaker":"Eduardo Bravo","startTime":261.035,"endTime":264.455,"body":"sometimes, in my case, it was"},{"speaker":"Eduardo Bravo","startTime":261.035,"endTime":264.455,"body":"not sophisticated investors. It"},{"speaker":"Eduardo Bravo","startTime":264.815,"endTime":266.435,"body":"was not an easy landing."},{"speaker":"John Simboli","startTime":266.3,"endTime":269.3,"body":"Do you remember"},{"speaker":"John Simboli","startTime":266.3,"endTime":269.3,"body":"any, either in the first go"},{"speaker":"John Simboli","startTime":269.3,"endTime":272.84,"body":"round or here Citryll, any"},{"speaker":"John Simboli","startTime":269.3,"endTime":272.84,"body":"things that were a surprise as"},{"speaker":"John Simboli","startTime":272.84,"endTime":275.84,"body":"far as what it means to be the"},{"speaker":"John Simboli","startTime":272.84,"endTime":275.84,"body":"leader of a biopharma company,"},{"speaker":"John Simboli","startTime":275.84,"endTime":278.0,"body":"rather than be a member of a"},{"speaker":"John Simboli","startTime":275.84,"endTime":278.0,"body":"large company?"},{"speaker":"Eduardo Bravo","startTime":277.52,"endTime":280.129,"body":"In pharma, you"},{"speaker":"Eduardo Bravo","startTime":277.52,"endTime":280.129,"body":"have a structure. I mean, the"},{"speaker":"Eduardo Bravo","startTime":280.188,"endTime":284.043,"body":"good and the bad is that you are"},{"speaker":"Eduardo Bravo","startTime":280.188,"endTime":284.043,"body":"a small piece of a huge machine."},{"speaker":"Eduardo Bravo","startTime":284.102,"endTime":287.483,"body":"The machine takes care of"},{"speaker":"Eduardo Bravo","startTime":284.102,"endTime":287.483,"body":"everything, most of it. The bad"},{"speaker":"Eduardo Bravo","startTime":287.542,"endTime":290.566,"body":"part is that, you know, you feel"},{"speaker":"Eduardo Bravo","startTime":287.542,"endTime":290.566,"body":"yourself as just a"},{"speaker":"Eduardo Bravo","startTime":290.626,"endTime":294.421,"body":"non-contributor, And it depends,"},{"speaker":"Eduardo Bravo","startTime":290.626,"endTime":294.421,"body":"some people are very happy like"},{"speaker":"Eduardo Bravo","startTime":294.481,"endTime":297.98,"body":"that. But, you know, I felt"},{"speaker":"Eduardo Bravo","startTime":294.481,"endTime":297.98,"body":"like, you know, I would like to"},{"speaker":"Eduardo Bravo","startTime":297.2,"endTime":374.12,"body":"to understand how"},{"speaker":"Eduardo Bravo","startTime":297.2,"endTime":374.12,"body":"little you know, and you need to"},{"speaker":"Eduardo Bravo","startTime":298.039,"endTime":301.241,"body":"see whether I can make a"},{"speaker":"Eduardo Bravo","startTime":298.039,"endTime":301.241,"body":"difference. And moving it was"},{"speaker":"Eduardo Bravo","startTime":301.301,"endTime":304.562,"body":"not Citryll it was Engitix in"},{"speaker":"Eduardo Bravo","startTime":301.301,"endTime":304.562,"body":"Spain, a very, very small"},{"speaker":"Eduardo Bravo","startTime":304.622,"endTime":308.061,"body":"biotech in the cell therapy"},{"speaker":"Eduardo Bravo","startTime":304.622,"endTime":308.061,"body":"space where, you know, we were"},{"speaker":"Eduardo Bravo","startTime":308.121,"endTime":311.857,"body":"making the calls. I mean, it's"},{"speaker":"Eduardo Bravo","startTime":308.121,"endTime":311.857,"body":"like, we're going to go for this"},{"speaker":"Eduardo Bravo","startTime":311.916,"endTime":315.415,"body":"indication, and it's us. And,"},{"speaker":"Eduardo Bravo","startTime":311.916,"endTime":315.415,"body":"you know, remember telling at"},{"speaker":"Eduardo Bravo","startTime":315.474,"endTime":319.092,"body":"that time a very inexperienced"},{"speaker":"Eduardo Bravo","startTime":315.474,"endTime":319.092,"body":"management, team guys, we have"},{"speaker":"Eduardo Bravo","startTime":319.151,"endTime":322.769,"body":"the money because we've been"},{"speaker":"Eduardo Bravo","startTime":319.151,"endTime":322.769,"body":"given the money. It's on us. You"},{"speaker":"Eduardo Bravo","startTime":322.828,"endTime":326.208,"body":"know, if we fail, we cannot"},{"speaker":"Eduardo Bravo","startTime":322.828,"endTime":326.208,"body":"blame anyone. You know, we're"},{"speaker":"Eduardo Bravo","startTime":326.268,"endTime":329.885,"body":"making the calls, we're calling"},{"speaker":"Eduardo Bravo","startTime":326.268,"endTime":329.885,"body":"the shots. So it's on us. And"},{"speaker":"Eduardo Bravo","startTime":329.945,"endTime":333.444,"body":"you know, we made some good"},{"speaker":"Eduardo Bravo","startTime":329.945,"endTime":333.444,"body":"calls. We made some sub-optimal"},{"speaker":"Eduardo Bravo","startTime":333.503,"endTime":337.002,"body":"calls. We learned a lot all"},{"speaker":"Eduardo Bravo","startTime":333.503,"endTime":337.002,"body":"together. And, you know, at the"},{"speaker":"Eduardo Bravo","startTime":337.061,"endTime":338.9,"body":"end, it was a successful story."},{"speaker":"Eduardo Bravo","startTime":374.24,"endTime":378.38,"body":"make calculated bets. And"},{"speaker":"Eduardo Bravo","startTime":374.24,"endTime":378.38,"body":"sometimes you know, I remember,"},{"speaker":"Eduardo Bravo","startTime":378.38,"endTime":381.68,"body":"you know, but not only in the"},{"speaker":"Eduardo Bravo","startTime":378.38,"endTime":381.68,"body":"team surrounding the company,"},{"speaker":"Eduardo Bravo","startTime":381.68,"endTime":384.68,"body":"but also at the board, we had Ed"},{"speaker":"Eduardo Bravo","startTime":381.68,"endTime":384.68,"body":"Holdener, who was the ex-CMO of"},{"speaker":"Eduardo Bravo","startTime":384.68,"endTime":389.72,"body":"Roche, which I will have all the"},{"speaker":"Eduardo Bravo","startTime":384.68,"endTime":389.72,"body":"respect for him, because he was"},{"speaker":"Eduardo Bravo","startTime":389.72,"endTime":392.9,"body":"always saying, like, we're doing"},{"speaker":"Eduardo Bravo","startTime":389.72,"endTime":392.9,"body":"an experiment. I mean, at the"},{"speaker":"Eduardo Bravo","startTime":392.9,"endTime":396.725,"body":"end, you know, we're testing a"},{"speaker":"Eduardo Bravo","startTime":392.9,"endTime":396.725,"body":"hypothesis. So a negative"},{"speaker":"Eduardo Bravo","startTime":396.725,"endTime":399.725,"body":"clinical trial is just that, you"},{"speaker":"Eduardo Bravo","startTime":396.725,"endTime":399.725,"body":"know, the hypothesis was not"},{"speaker":"Eduardo Bravo","startTime":399.725,"endTime":402.365,"body":"correct. Of course, it's not"},{"speaker":"Eduardo Bravo","startTime":399.725,"endTime":402.365,"body":"what investors want, is not what"},{"speaker":"Eduardo Bravo","startTime":402.365,"endTime":407.045,"body":"the management wants, but this"},{"speaker":"Eduardo Bravo","startTime":402.365,"endTime":407.045,"body":"is it. I mean, you're given the"},{"speaker":"Eduardo Bravo","startTime":407.045,"endTime":411.665,"body":"money to run a hypothesis, and"},{"speaker":"Eduardo Bravo","startTime":407.045,"endTime":411.665,"body":"the hypothesis, with all the"},{"speaker":"Eduardo Bravo","startTime":411.665,"endTime":415.505,"body":"information you have, is the"},{"speaker":"Eduardo Bravo","startTime":411.665,"endTime":415.505,"body":"best possible hypothesis. And I"},{"speaker":"Eduardo Bravo","startTime":415.505,"endTime":419.63,"body":"keep also telling my teams over"},{"speaker":"Eduardo Bravo","startTime":415.505,"endTime":419.63,"body":"and over again that our job is"},{"speaker":"Eduardo Bravo","startTime":419.63,"endTime":424.19,"body":"to reduce all the risk to the"},{"speaker":"Eduardo Bravo","startTime":419.63,"endTime":424.19,"body":"technology risk. You know, if"},{"speaker":"Eduardo Bravo","startTime":424.19,"endTime":427.49,"body":"the product at the end fails"},{"speaker":"Eduardo Bravo","startTime":424.19,"endTime":427.49,"body":"because the hypothesis was"},{"speaker":"Eduardo Bravo","startTime":427.49,"endTime":430.73,"body":"wrong, the mechanism doesn't"},{"speaker":"Eduardo Bravo","startTime":427.49,"endTime":430.73,"body":"fly, it's out of your control."},{"speaker":"Eduardo Bravo","startTime":431.03,"endTime":433.91,"body":"If you choose the wrong"},{"speaker":"Eduardo Bravo","startTime":431.03,"endTime":433.91,"body":"indication, if you go to the"},{"speaker":"Eduardo Bravo","startTime":433.91,"endTime":438.23,"body":"wrong patients, if you design"},{"speaker":"Eduardo Bravo","startTime":433.91,"endTime":438.23,"body":"the wrong clinical trial, if you"},{"speaker":"Eduardo Bravo","startTime":438.23,"endTime":441.935,"body":"do the CMC wrong, if you cut"},{"speaker":"Eduardo Bravo","startTime":438.23,"endTime":441.935,"body":"corners that should be not cut,"},{"speaker":"Eduardo Bravo","startTime":441.995,"endTime":446.075,"body":"if you go the wrong way in the"},{"speaker":"Eduardo Bravo","startTime":441.995,"endTime":446.075,"body":"regulatory path, that's on you."},{"speaker":"Eduardo Bravo","startTime":446.495,"endTime":448.895,"body":"That's what management is"},{"speaker":"Eduardo Bravo","startTime":446.495,"endTime":448.895,"body":"supposed to be doing. It's like,"},{"speaker":"Eduardo Bravo","startTime":448.895,"endTime":451.775,"body":"okay, take away as much as"},{"speaker":"Eduardo Bravo","startTime":448.895,"endTime":451.775,"body":"possible all the other risks,"},{"speaker":"Eduardo Bravo","startTime":452.255,"endTime":456.275,"body":"and investors should be faced"},{"speaker":"Eduardo Bravo","startTime":452.255,"endTime":456.275,"body":"with the technology risk, which"},{"speaker":"Eduardo Bravo","startTime":456.335,"endTime":457.175,"body":"you cannot control."},{"speaker":"John Simboli","startTime":457.595,"endTime":460.415,"body":"As you consult"},{"speaker":"John Simboli","startTime":457.595,"endTime":460.415,"body":"with your team to try to get the"},{"speaker":"John Simboli","startTime":460.415,"endTime":463.235,"body":"most information, and then in"},{"speaker":"John Simboli","startTime":460.415,"endTime":463.235,"body":"the end, you're responsible for"},{"speaker":"John Simboli","startTime":463.235,"endTime":468.2,"body":"making that choice terms of"},{"speaker":"John Simboli","startTime":463.235,"endTime":468.2,"body":"direction, how do you deal with"},{"speaker":"John Simboli","startTime":468.56,"endTime":472.1,"body":"the fact that sometimes that is"},{"speaker":"John Simboli","startTime":468.56,"endTime":472.1,"body":"the wrong decision? In other"},{"speaker":"John Simboli","startTime":472.1,"endTime":474.74,"body":"words, one CEO I spoke with"},{"speaker":"John Simboli","startTime":472.1,"endTime":474.74,"body":"said, you know, I had to get"},{"speaker":"John Simboli","startTime":474.74,"endTime":478.1,"body":"over my fear of making a wrong"},{"speaker":"John Simboli","startTime":474.74,"endTime":478.1,"body":"decision and realizing I might"},{"speaker":"John Simboli","startTime":478.1,"endTime":481.76,"body":"likely be able to correct it"},{"speaker":"John Simboli","startTime":478.1,"endTime":481.76,"body":"down the road. So I guess, what"},{"speaker":"John Simboli","startTime":481.76,"endTime":485.72,"body":"I'm trying to get at is, how do"},{"speaker":"John Simboli","startTime":481.76,"endTime":485.72,"body":"you separate the fact finding"},{"speaker":"John Simboli","startTime":485.72,"endTime":488.765,"body":"with the team from the I'm going"},{"speaker":"John Simboli","startTime":485.72,"endTime":488.765,"body":"to make the choice, and I might"},{"speaker":"John Simboli","startTime":488.765,"endTime":489.905,"body":"be right and I might be wrong?"},{"speaker":"Eduardo Bravo","startTime":490.08,"endTime":492.12,"body":"Well, I think"},{"speaker":"Eduardo Bravo","startTime":490.08,"endTime":492.12,"body":"that we all know that every"},{"speaker":"Eduardo Bravo","startTime":492.12,"endTime":497.46,"body":"decision is a guess, and you're"},{"speaker":"Eduardo Bravo","startTime":492.12,"endTime":497.46,"body":"just taking your best guess. And"},{"speaker":"Eduardo Bravo","startTime":497.46,"endTime":501.06,"body":"I truly believe that the best"},{"speaker":"Eduardo Bravo","startTime":497.46,"endTime":501.06,"body":"people are taking those"},{"speaker":"Eduardo Bravo","startTime":501.06,"endTime":504.78,"body":"decisions are the ones that have"},{"speaker":"Eduardo Bravo","startTime":501.06,"endTime":504.78,"body":"no fear in recognizing very"},{"speaker":"Eduardo Bravo","startTime":504.78,"endTime":508.2,"body":"quickly that it was the wrong"},{"speaker":"Eduardo Bravo","startTime":504.78,"endTime":508.2,"body":"call and that you can, most of"},{"speaker":"Eduardo Bravo","startTime":508.2,"endTime":512.4,"body":"the times, change your mind. And"},{"speaker":"Eduardo Bravo","startTime":508.2,"endTime":512.4,"body":"again, I am a strong believer"},{"speaker":"Eduardo Bravo","startTime":512.4,"endTime":517.125,"body":"that, you know, you try, you"},{"speaker":"Eduardo Bravo","startTime":512.4,"endTime":517.125,"body":"make a call, you try, and you"},{"speaker":"Eduardo Bravo","startTime":517.125,"endTime":519.765,"body":"should be analyzing very"},{"speaker":"Eduardo Bravo","startTime":517.125,"endTime":519.765,"body":"quickly. You know, does it make"},{"speaker":"Eduardo Bravo","startTime":519.765,"endTime":523.305,"body":"sense? Is this improving or not?"},{"speaker":"Eduardo Bravo","startTime":519.765,"endTime":523.305,"body":"And if not, let's try something"},{"speaker":"Eduardo Bravo","startTime":523.305,"endTime":526.245,"body":"else. I love copying as well,"},{"speaker":"Eduardo Bravo","startTime":523.305,"endTime":526.245,"body":"you know, I you know, every time"},{"speaker":"Eduardo Bravo","startTime":526.245,"endTime":529.185,"body":"we recruit someone and say like,"},{"speaker":"Eduardo Bravo","startTime":526.245,"endTime":529.185,"body":"well, especially the first three"},{"speaker":"Eduardo Bravo","startTime":529.185,"endTime":532.845,"body":"months, because after three"},{"speaker":"Eduardo Bravo","startTime":529.185,"endTime":532.845,"body":"months, people become, you know,"},{"speaker":"Eduardo Bravo","startTime":533.385,"endTime":535.95,"body":"part of the company. You know,"},{"speaker":"Eduardo Bravo","startTime":533.385,"endTime":535.95,"body":"the first three months, you look"},{"speaker":"Eduardo Bravo","startTime":535.95,"endTime":538.89,"body":"at things with critical eyes,"},{"speaker":"Eduardo Bravo","startTime":535.95,"endTime":538.89,"body":"usually when you arrive into"},{"speaker":"Eduardo Bravo","startTime":538.89,"endTime":541.95,"body":"companies like, well, if you see"},{"speaker":"Eduardo Bravo","startTime":538.89,"endTime":541.95,"body":"anything that we're doing, that"},{"speaker":"Eduardo Bravo","startTime":541.95,"endTime":545.61,"body":"you've seen anywhere in your"},{"speaker":"Eduardo Bravo","startTime":541.95,"endTime":545.61,"body":"career done better, faster,"},{"speaker":"Eduardo Bravo","startTime":545.61,"endTime":549.99,"body":"cheaper, tell us. Because, you"},{"speaker":"Eduardo Bravo","startTime":545.61,"endTime":549.99,"body":"know, here there's no right way"},{"speaker":"Eduardo Bravo","startTime":549.99,"endTime":552.75,"body":"of doing things. We will do"},{"speaker":"Eduardo Bravo","startTime":549.99,"endTime":552.75,"body":"whatever. And if there's a"},{"speaker":"Eduardo Bravo","startTime":552.75,"endTime":555.75,"body":"better way, we will try. And if"},{"speaker":"Eduardo Bravo","startTime":552.75,"endTime":555.75,"body":"it works, we keep it, and if it"},{"speaker":"Eduardo Bravo","startTime":555.75,"endTime":560.175,"body":"doesn't, we go back. But, you"},{"speaker":"Eduardo Bravo","startTime":555.75,"endTime":560.175,"body":"know, not changing or being"},{"speaker":"Eduardo Bravo","startTime":560.175,"endTime":564.495,"body":"obsessed with your way of doing"},{"speaker":"Eduardo Bravo","startTime":560.175,"endTime":564.495,"body":"things, I think, is the recipe"},{"speaker":"Eduardo Bravo","startTime":564.495,"endTime":568.275,"body":"for failure. And sometimes the"},{"speaker":"Eduardo Bravo","startTime":564.495,"endTime":568.275,"body":"bets are very long term. I mean,"},{"speaker":"Eduardo Bravo","startTime":568.275,"endTime":571.035,"body":"when you start a clinical trial,"},{"speaker":"Eduardo Bravo","startTime":568.275,"endTime":571.035,"body":"you cannot change three months"},{"speaker":"Eduardo Bravo","startTime":571.035,"endTime":573.915,"body":"later. It's like off . . . It"},{"speaker":"Eduardo Bravo","startTime":571.035,"endTime":573.915,"body":"was the wrong indication. I"},{"speaker":"Eduardo Bravo","startTime":573.915,"endTime":579.075,"body":"mean, you're probably committed."},{"speaker":"Eduardo Bravo","startTime":573.915,"endTime":579.075,"body":"So you also need to understand"},{"speaker":"Eduardo Bravo","startTime":580.095,"endTime":581.09,"body":"that there are certain decisions"},{"speaker":"Eduardo Bravo","startTime":580.095,"endTime":581.09,"body":"where you need to spend a lot of"},{"speaker":"Eduardo Bravo","startTime":581.09,"endTime":583.26,"body":"money and energy and time making"},{"speaker":"Eduardo Bravo","startTime":581.09,"endTime":583.26,"body":"sure that you make the best"},{"speaker":"Eduardo Bravo","startTime":583.26,"endTime":586.2,"body":"possible call. But also, you"},{"speaker":"Eduardo Bravo","startTime":583.26,"endTime":586.2,"body":"know that there's a lot of"},{"speaker":"Eduardo Bravo","startTime":586.2,"endTime":589.8,"body":"decisions where you should just"},{"speaker":"Eduardo Bravo","startTime":586.2,"endTime":589.8,"body":"take it, because not taking a"},{"speaker":"Eduardo Bravo","startTime":589.8,"endTime":595.2,"body":"decision is a course of action."},{"speaker":"Eduardo Bravo","startTime":589.8,"endTime":595.2,"body":"Inaction is pretty bad in the"},{"speaker":"Eduardo Bravo","startTime":595.2,"endTime":596.46,"body":"majority of the cases."},{"speaker":"John Simboli","startTime":596.64,"endTime":598.98,"body":"Coming from a"},{"speaker":"John Simboli","startTime":596.64,"endTime":598.98,"body":"non-science background, to lead"},{"speaker":"John Simboli","startTime":598.98,"endTime":603.06,"body":"a scientific company brings up"},{"speaker":"John Simboli","startTime":598.98,"endTime":603.06,"body":"the question, earlier in your"},{"speaker":"John Simboli","startTime":603.12,"endTime":607.305,"body":"education and your life view,"},{"speaker":"John Simboli","startTime":603.12,"endTime":607.305,"body":"what path did you see yourself"},{"speaker":"John Simboli","startTime":607.305,"endTime":608.565,"body":"on, if not this one?"},{"speaker":"Eduardo Bravo","startTime":609.14,"endTime":613.22,"body":"Definitely not"},{"speaker":"Eduardo Bravo","startTime":609.14,"endTime":613.22,"body":"this one. You know, it's amazing"},{"speaker":"Eduardo Bravo","startTime":613.22,"endTime":618.26,"body":"how many times I tried to move"},{"speaker":"Eduardo Bravo","startTime":613.22,"endTime":618.26,"body":"out of the pharmaceutical space"},{"speaker":"Eduardo Bravo","startTime":618.26,"endTime":623.06,"body":"despite, you know, my family is"},{"speaker":"Eduardo Bravo","startTime":618.26,"endTime":623.06,"body":"a family of doctors, so I'm, you"},{"speaker":"Eduardo Bravo","startTime":623.06,"endTime":626.6,"body":"know, I've been very close. But"},{"speaker":"Eduardo Bravo","startTime":623.06,"endTime":626.6,"body":"I have an older brother, and"},{"speaker":"Eduardo Bravo","startTime":626.6,"endTime":628.88,"body":"probably, you know how those"},{"speaker":"Eduardo Bravo","startTime":626.6,"endTime":628.88,"body":"things go, my older brother then"},{"speaker":"Eduardo Bravo","startTime":628.88,"endTime":631.019,"body":"decided to follow my father's"},{"speaker":"Eduardo Bravo","startTime":628.88,"endTime":631.019,"body":"steps as a doctor. So then I"},{"speaker":"Eduardo Bravo","startTime":631.019,"endTime":635.525,"body":"decided I'm not going to be a"},{"speaker":"Eduardo Bravo","startTime":631.019,"endTime":635.525,"body":"doctor as well. And I was good"},{"speaker":"Eduardo Bravo","startTime":635.525,"endTime":639.605,"body":"at numbers, so I like math, and"},{"speaker":"Eduardo Bravo","startTime":635.525,"endTime":639.605,"body":"I like the money, so I decided"},{"speaker":"Eduardo Bravo","startTime":639.605,"endTime":643.085,"body":"I'm going to be a banker. And,"},{"speaker":"Eduardo Bravo","startTime":639.605,"endTime":643.085,"body":"you know, I could not find a job"},{"speaker":"Eduardo Bravo","startTime":643.085,"endTime":647.045,"body":"as a banker when I wanted to do"},{"speaker":"Eduardo Bravo","startTime":643.085,"endTime":647.045,"body":"a training. And through the"},{"speaker":"Eduardo Bravo","startTime":647.045,"endTime":653.045,"body":"priest of the of the church of"},{"speaker":"Eduardo Bravo","startTime":647.045,"endTime":653.045,"body":"San Luis De Los Franceses, in"},{"speaker":"Eduardo Bravo","startTime":653.045,"endTime":657.77,"body":"Madrid. And the priest was a"},{"speaker":"Eduardo Bravo","startTime":653.045,"endTime":657.77,"body":"friend of my mother's friend,"},{"speaker":"Eduardo Bravo","startTime":658.31,"endTime":663.23,"body":"and he went to school with the"},{"speaker":"Eduardo Bravo","startTime":658.31,"endTime":663.23,"body":"head of HR of Pierre Fabre in"},{"speaker":"Eduardo Bravo","startTime":663.23,"endTime":666.59,"body":"Paris. So I ended up as a"},{"speaker":"Eduardo Bravo","startTime":663.23,"endTime":666.59,"body":"trainee in the oncology"},{"speaker":"Eduardo Bravo","startTime":666.59,"endTime":669.41,"body":"department of Pierre Fabre."},{"speaker":"Eduardo Bravo","startTime":666.59,"endTime":669.41,"body":"Never thought that I was going"},{"speaker":"Eduardo Bravo","startTime":669.41,"endTime":672.23,"body":"to be there, but I wanted to"},{"speaker":"Eduardo Bravo","startTime":669.41,"endTime":672.23,"body":"learn French because I wanted to"},{"speaker":"Eduardo Bravo","startTime":672.23,"endTime":675.59,"body":"do INSEAD so like, who cares? I"},{"speaker":"Eduardo Bravo","startTime":672.23,"endTime":675.59,"body":"do this, and then I will go into"},{"speaker":"Eduardo Bravo","startTime":675.59,"endTime":678.935,"body":"banking. Then I got a job as a"},{"speaker":"Eduardo Bravo","startTime":675.59,"endTime":678.935,"body":"banker in London one year later."},{"speaker":"Eduardo Bravo","startTime":678.935,"endTime":682.895,"body":"Like, that's what I want to do."},{"speaker":"Eduardo Bravo","startTime":678.935,"endTime":682.895,"body":"So here I go, except that I"},{"speaker":"Eduardo Bravo","startTime":683.495,"endTime":688.055,"body":"resigned from from Pierre Fabre,"},{"speaker":"Eduardo Bravo","startTime":683.495,"endTime":688.055,"body":"and then found myself that, you"},{"speaker":"Eduardo Bravo","startTime":688.055,"endTime":691.895,"body":"know, I needed a work permit"},{"speaker":"Eduardo Bravo","startTime":688.055,"endTime":691.895,"body":"because Spain was not part of"},{"speaker":"Eduardo Bravo","startTime":691.895,"endTime":695.855,"body":"the EU. Had to go back to the"},{"speaker":"Eduardo Bravo","startTime":691.895,"endTime":695.855,"body":"industry. And then went to"},{"speaker":"Eduardo Bravo","startTime":695.855,"endTime":698.795,"body":"INSEAD, and I wanted to get out"},{"speaker":"Eduardo Bravo","startTime":695.855,"endTime":698.795,"body":"of the industry. But then at"},{"speaker":"Eduardo Bravo","startTime":698.795,"endTime":702.8,"body":"INSEAD, I really made the"},{"speaker":"Eduardo Bravo","startTime":698.795,"endTime":702.8,"body":"conscious decision—what I like"},{"speaker":"Eduardo Bravo","startTime":703.46,"endTime":706.94,"body":"is to manage teams. I don't care"},{"speaker":"Eduardo Bravo","startTime":703.46,"endTime":706.94,"body":"the industry. I want to have"},{"speaker":"Eduardo Bravo","startTime":706.94,"endTime":710.78,"body":"teams, and I want to be able to"},{"speaker":"Eduardo Bravo","startTime":706.94,"endTime":710.78,"body":"manage through people. That is"},{"speaker":"Eduardo Bravo","startTime":710.78,"endTime":714.32,"body":"what I like, that's what I think"},{"speaker":"Eduardo Bravo","startTime":710.78,"endTime":714.32,"body":"that I do. Well, that's what for"},{"speaker":"Eduardo Bravo","startTime":714.32,"endTime":717.74,"body":"other people to judge, but that"},{"speaker":"Eduardo Bravo","startTime":714.32,"endTime":717.74,"body":"was my internal thinking. And I"},{"speaker":"Eduardo Bravo","startTime":717.74,"endTime":720.92,"body":"went back to () at that time"},{"speaker":"Eduardo Bravo","startTime":717.74,"endTime":720.92,"body":"because they offered me the"},{"speaker":"Eduardo Bravo","startTime":720.92,"endTime":724.22,"body":"biggest team of all the jobs"},{"speaker":"Eduardo Bravo","startTime":720.92,"endTime":724.22,"body":"that I had when I left. And I"},{"speaker":"Eduardo Bravo","startTime":724.265,"endTime":727.445,"body":"was super happy with that, and"},{"speaker":"Eduardo Bravo","startTime":724.265,"endTime":727.445,"body":"that was back in the industry."},{"speaker":"Eduardo Bravo","startTime":727.445,"endTime":730.205,"body":"And, you know, 30 years later,"},{"speaker":"Eduardo Bravo","startTime":727.445,"endTime":730.205,"body":"here I am."},{"speaker":"John Simboli","startTime":730.66,"endTime":734.44,"body":"At INSEAD, what"},{"speaker":"John Simboli","startTime":730.66,"endTime":734.44,"body":"realization did you have about"},{"speaker":"John Simboli","startTime":734.44,"endTime":737.62,"body":"managing teams? What did you"},{"speaker":"John Simboli","startTime":734.44,"endTime":737.62,"body":"find out about yourself that you"},{"speaker":"John Simboli","startTime":737.62,"endTime":740.2,"body":"realized I like this, and I'm"},{"speaker":"John Simboli","startTime":737.62,"endTime":740.2,"body":"good at this?"},{"speaker":"Eduardo Bravo","startTime":739.86,"endTime":743.099,"body":"I've always liked"},{"speaker":"Eduardo Bravo","startTime":739.86,"endTime":743.099,"body":"it, and I had a very small team"},{"speaker":"Eduardo Bravo","startTime":743.165,"endTime":747.198,"body":"when I left for INSEAD, but it"},{"speaker":"Eduardo Bravo","startTime":743.165,"endTime":747.198,"body":"was this idea I really enjoyed"},{"speaker":"Eduardo Bravo","startTime":747.264,"endTime":751.297,"body":"all the management. I saw, that"},{"speaker":"Eduardo Bravo","startTime":747.264,"endTime":751.297,"body":"I was attracted to that area,"},{"speaker":"Eduardo Bravo","startTime":751.363,"endTime":755.263,"body":"that's the area where I was"},{"speaker":"Eduardo Bravo","startTime":751.363,"endTime":755.263,"body":"reading the most. I felt that I"},{"speaker":"Eduardo Bravo","startTime":755.329,"endTime":759.362,"body":"was pretty natural, but I had"},{"speaker":"Eduardo Bravo","startTime":755.329,"endTime":759.362,"body":"the option of going into bigger"},{"speaker":"Eduardo Bravo","startTime":759.428,"endTime":763.064,"body":"jobs that were usually better"},{"speaker":"Eduardo Bravo","startTime":759.428,"endTime":763.064,"body":"for MBAs, which are staff"},{"speaker":"Eduardo Bravo","startTime":763.13,"endTime":766.634,"body":"positions, and I was not"},{"speaker":"Eduardo Bravo","startTime":763.13,"endTime":766.634,"body":"attracted to that. I was not"},{"speaker":"Eduardo Bravo","startTime":766.7,"endTime":770.535,"body":"attracted at that time by the"},{"speaker":"Eduardo Bravo","startTime":766.7,"endTime":770.535,"body":"money or the position. I was"},{"speaker":"John Simboli","startTime":768.605,"endTime":777.365,"body":"If someone were to"},{"speaker":"John Simboli","startTime":768.605,"endTime":777.365,"body":"ask your teammates, what is it"},{"speaker":"John Simboli","startTime":770.601,"endTime":774.7,"body":"more attracted to the, this is"},{"speaker":"John Simboli","startTime":770.601,"endTime":774.7,"body":"what I like. I want to do this."},{"speaker":"John Simboli","startTime":777.365,"endTime":780.185,"body":"that makes him good at managing"},{"speaker":"John Simboli","startTime":777.365,"endTime":780.185,"body":"this team or leading this team?"},{"speaker":"John Simboli","startTime":780.185,"endTime":782.225,"body":"What do you think your"},{"speaker":"John Simboli","startTime":780.185,"endTime":782.225,"body":"colleagues would say?"},{"speaker":"Eduardo Bravo","startTime":782.48,"endTime":785.06,"body":"Yeah, I think"},{"speaker":"Eduardo Bravo","startTime":782.48,"endTime":785.06,"body":"that I bring a lot of focus and"},{"speaker":"Eduardo Bravo","startTime":785.06,"endTime":790.58,"body":"direction, but I leave a huge"},{"speaker":"Eduardo Bravo","startTime":785.06,"endTime":790.58,"body":"amount of liberty to the people"},{"speaker":"Eduardo Bravo","startTime":790.58,"endTime":794.9,"body":"below. So you can say that I do"},{"speaker":"Eduardo Bravo","startTime":790.58,"endTime":794.9,"body":"not micro-manage, and I'm a"},{"speaker":"Eduardo Bravo","startTime":794.9,"endTime":798.86,"body":"fanatic of pushing people"},{"speaker":"Eduardo Bravo","startTime":794.9,"endTime":798.86,"body":"further and further. I'm good at"},{"speaker":"Eduardo Bravo","startTime":798.86,"endTime":802.94,"body":"challenging the people to keep"},{"speaker":"Eduardo Bravo","startTime":798.86,"endTime":802.94,"body":"growing and, you know, also"},{"speaker":"Eduardo Bravo","startTime":803.18,"endTime":806.645,"body":"keeping calm when things do not"},{"speaker":"Eduardo Bravo","startTime":803.18,"endTime":806.645,"body":"go well. I'm very good at"},{"speaker":"Eduardo Bravo","startTime":806.645,"endTime":809.645,"body":"keeping people informed as well."},{"speaker":"Eduardo Bravo","startTime":806.645,"endTime":809.645,"body":"I mean, for me, communication to"},{"speaker":"Eduardo Bravo","startTime":809.645,"endTime":813.305,"body":"the people, they need to know"},{"speaker":"Eduardo Bravo","startTime":809.645,"endTime":813.305,"body":"what you're doing and why you're"},{"speaker":"Eduardo Bravo","startTime":813.305,"endTime":816.485,"body":"doing it. That's my job as a"},{"speaker":"Eduardo Bravo","startTime":813.305,"endTime":816.485,"body":"leader, is to challenge the"},{"speaker":"Eduardo Bravo","startTime":816.485,"endTime":821.405,"body":"people to think. You know, if"},{"speaker":"Eduardo Bravo","startTime":816.485,"endTime":821.405,"body":"they cannot convince me, Wow, I"},{"speaker":"Eduardo Bravo","startTime":821.465,"endTime":826.445,"body":"become nervous. So I'm a pain in"},{"speaker":"Eduardo Bravo","startTime":821.465,"endTime":826.445,"body":"the neck asking, but if I get"},{"speaker":"Eduardo Bravo","startTime":826.445,"endTime":830.15,"body":"convinced that I'm like, Okay,"},{"speaker":"Eduardo Bravo","startTime":826.445,"endTime":830.15,"body":"this is under control, I'm happy"},{"speaker":"Eduardo Bravo","startTime":830.15,"endTime":830.57,"body":"with that."},{"speaker":"John Simboli","startTime":831.41,"endTime":834.71,"body":"When you get that,"},{"speaker":"John Simboli","startTime":831.41,"endTime":834.71,"body":"just tell me about Citryll, and"},{"speaker":"John Simboli","startTime":834.71,"endTime":838.076,"body":"you realize you only have a very"},{"speaker":"John Simboli","startTime":834.71,"endTime":838.076,"body":"short period of time, how do you"},{"speaker":"Eduardo Bravo","startTime":838.42,"endTime":841.92,"body":"We're a private"},{"speaker":"Eduardo Bravo","startTime":838.42,"endTime":841.92,"body":"biotech company based in the"},{"speaker":"Eduardo Bravo","startTime":841.92,"endTime":846.72,"body":"Netherlands that has a"},{"speaker":"Eduardo Bravo","startTime":841.92,"endTime":846.72,"body":"monoclonal antibody targeting a"},{"speaker":"Eduardo Bravo","startTime":846.72,"endTime":852.42,"body":"very new mechanism of action"},{"speaker":"Eduardo Bravo","startTime":846.72,"endTime":852.42,"body":"that hopefully will be able to"},{"speaker":"Eduardo Bravo","startTime":852.42,"endTime":856.14,"body":"solve a lot of the inflammatory"},{"speaker":"Eduardo Bravo","startTime":852.42,"endTime":856.14,"body":"diseases which are common to"},{"speaker":"Eduardo Bravo","startTime":856.14,"endTime":858.48,"body":"many, many diseases in the"},{"speaker":"Eduardo Bravo","startTime":856.14,"endTime":858.48,"body":"world."},{"speaker":"John Simboli","startTime":859.2,"endTime":862.2,"body":"Can you describe"},{"speaker":"John Simboli","startTime":859.2,"endTime":862.2,"body":"what that gap is, and was? In"},{"speaker":"John Simboli","startTime":862.2,"endTime":865.74,"body":"what ways were patients not"},{"speaker":"John Simboli","startTime":862.2,"endTime":865.74,"body":"being served, that was needed"},{"speaker":"John Simboli","startTime":865.74,"endTime":867.54,"body":"for a company like yours to come"},{"speaker":"John Simboli","startTime":865.74,"endTime":867.54,"body":"along?"},{"speaker":"Eduardo Bravo","startTime":867.9,"endTime":870.78,"body":"If you look at"},{"speaker":"Eduardo Bravo","startTime":867.9,"endTime":870.78,"body":"the immune mediated inflammatory"},{"speaker":"Eduardo Bravo","startTime":870.78,"endTime":876.0,"body":"diseases, and despite the"},{"speaker":"Eduardo Bravo","startTime":870.78,"endTime":876.0,"body":"incredible advances that have"},{"speaker":"Eduardo Bravo","startTime":876.0,"endTime":879.12,"body":"happened since biologics"},{"speaker":"Eduardo Bravo","startTime":876.0,"endTime":879.12,"body":"arrived, I mean, I can think"},{"speaker":"Eduardo Bravo","startTime":879.48,"endTime":882.06,"body":"rheumatoid arthritis and the"},{"speaker":"Eduardo Bravo","startTime":879.48,"endTime":882.06,"body":"arrival of Humira, the"},{"speaker":"Eduardo Bravo","startTime":882.06,"endTime":886.2,"body":"anti-TNFs, then the anti CD 20s,"},{"speaker":"Eduardo Bravo","startTime":882.06,"endTime":886.2,"body":"the Jak inhibitors, the IL 6."},{"speaker":"Eduardo Bravo","startTime":886.98,"endTime":889.68,"body":"You go to determinative, super"},{"speaker":"Eduardo Bravo","startTime":886.98,"endTime":889.68,"body":"active, and now with the"},{"speaker":"Eduardo Bravo","startTime":889.68,"endTime":894.225,"body":"appearance of the IL 17s. So"},{"speaker":"Eduardo Bravo","startTime":889.68,"endTime":894.225,"body":"psoriasis, I mean, you name it,"},{"speaker":"Eduardo Bravo","startTime":894.285,"endTime":898.665,"body":"all these diseases. If you look"},{"speaker":"Eduardo Bravo","startTime":894.285,"endTime":898.665,"body":"at the transformation over the"},{"speaker":"Eduardo Bravo","startTime":898.665,"endTime":902.445,"body":"last 20 years, it's pretty."},{"speaker":"Eduardo Bravo","startTime":898.665,"endTime":902.445,"body":"phenomenal. Now the problem is,"},{"speaker":"Eduardo Bravo","startTime":902.445,"endTime":908.265,"body":"if you look at where we are,"},{"speaker":"Eduardo Bravo","startTime":902.445,"endTime":908.265,"body":"there's, I would say, around 40,"},{"speaker":"Eduardo Bravo","startTime":908.625,"endTime":913.41,"body":"which is a pretty amazing"},{"speaker":"Eduardo Bravo","startTime":908.625,"endTime":913.41,"body":"number, 40% of the patients that"},{"speaker":"Eduardo Bravo","startTime":913.41,"endTime":919.29,"body":"are not adequately controlled"},{"speaker":"Eduardo Bravo","startTime":913.41,"endTime":919.29,"body":"with existing therapies. So, you"},{"speaker":"Eduardo Bravo","startTime":919.29,"endTime":923.79,"body":"know, there's, there's been a"},{"speaker":"Eduardo Bravo","startTime":919.29,"endTime":923.79,"body":"huge improvement, but the gap is"},{"speaker":"Eduardo Bravo","startTime":923.79,"endTime":926.79,"body":"still fantastic. It's like, you"},{"speaker":"Eduardo Bravo","startTime":923.79,"endTime":926.79,"body":"know, probably in oncology, you"},{"speaker":"Eduardo Bravo","startTime":926.79,"endTime":929.73,"body":"know, if you look at where we"},{"speaker":"Eduardo Bravo","startTime":926.79,"endTime":929.73,"body":"were, where we are, but you"},{"speaker":"Eduardo Bravo","startTime":929.73,"endTime":933.75,"body":"know, what remains to be done?"},{"speaker":"Eduardo Bravo","startTime":929.73,"endTime":933.75,"body":"Well, I think that inflammation"},{"speaker":"Eduardo Bravo","startTime":933.75,"endTime":937.23,"body":"is a little bit the same, and"},{"speaker":"Eduardo Bravo","startTime":933.75,"endTime":937.23,"body":"people have been looking in a"},{"speaker":"Eduardo Bravo","startTime":937.275,"endTime":941.355,"body":"very precise way, looking at all"},{"speaker":"Eduardo Bravo","startTime":937.275,"endTime":941.355,"body":"the, you know, downstream, every"},{"speaker":"Eduardo Bravo","startTime":941.475,"endTime":945.435,"body":"pro-inflammatory cytokine and"},{"speaker":"Eduardo Bravo","startTime":941.475,"endTime":945.435,"body":"marker, and how we can. You"},{"speaker":"Eduardo Bravo","startTime":945.435,"endTime":948.135,"body":"know, these NETs were discovered"},{"speaker":"Eduardo Bravo","startTime":945.435,"endTime":948.135,"body":"20 years ago. So we're talking"},{"speaker":"Eduardo Bravo","startTime":948.135,"endTime":954.075,"body":"yesterday for the pharma"},{"speaker":"Eduardo Bravo","startTime":948.135,"endTime":954.075,"body":"industry. You know, neutrophils,"},{"speaker":"Eduardo Bravo","startTime":954.135,"endTime":958.215,"body":"which, you know, I still have,"},{"speaker":"Eduardo Bravo","startTime":954.135,"endTime":958.215,"body":"my CSO that says, when he was at"},{"speaker":"Eduardo Bravo","startTime":958.215,"endTime":960.84,"body":"GSK, if things were touched by"},{"speaker":"Eduardo Bravo","startTime":958.215,"endTime":960.84,"body":"neutrophils, they would just"},{"speaker":"Eduardo Bravo","startTime":960.84,"endTime":964.2,"body":"shut them, you know, because no"},{"speaker":"Eduardo Bravo","startTime":960.84,"endTime":964.2,"body":"one understood neutrophils. It"},{"speaker":"Eduardo Bravo","startTime":964.2,"endTime":968.76,"body":"was part of the innate immune"},{"speaker":"Eduardo Bravo","startTime":964.2,"endTime":968.76,"body":"system. We don't want to mess"},{"speaker":"Eduardo Bravo","startTime":968.76,"endTime":972.18,"body":"with them, because they are the"},{"speaker":"Eduardo Bravo","startTime":968.76,"endTime":972.18,"body":"first responders to an issue in"},{"speaker":"Eduardo Bravo","startTime":972.18,"endTime":978.36,"body":"the body. So when those NETs"},{"speaker":"Eduardo Bravo","startTime":972.18,"endTime":978.36,"body":"were discovered, now, finding a"},{"speaker":"Eduardo Bravo","startTime":978.36,"endTime":984.225,"body":"way of, because we have the"},{"speaker":"Eduardo Bravo","startTime":978.36,"endTime":984.225,"body":"beauty of this dual mechanism,"},{"speaker":"Eduardo Bravo","startTime":984.945,"endTime":988.965,"body":"\"A,\" being able to inhibit"},{"speaker":"Eduardo Bravo","startTime":984.945,"endTime":988.965,"body":"additional NET release, so we"},{"speaker":"Eduardo Bravo","startTime":988.965,"endTime":994.785,"body":"can stop new NETs being"},{"speaker":"Eduardo Bravo","startTime":988.965,"endTime":994.785,"body":"released. And very importantly,"},{"speaker":"Eduardo Bravo","startTime":994.785,"endTime":997.965,"body":"and we believe is the most"},{"speaker":"Eduardo Bravo","startTime":994.785,"endTime":997.965,"body":"important of the two, we can"},{"speaker":"Eduardo Bravo","startTime":997.965,"endTime":1002.405,"body":"help clear the accumulation of"},{"speaker":"Eduardo Bravo","startTime":997.965,"endTime":1002.405,"body":"NETs in the tissue. So suddenly,"},{"speaker":"Eduardo Bravo","startTime":1002.465,"endTime":1006.365,"body":"if our hypothesis today,"},{"speaker":"Eduardo Bravo","startTime":1002.465,"endTime":1006.365,"body":"published by many, many groups"},{"speaker":"Eduardo Bravo","startTime":1006.41,"endTime":1013.55,"body":"in many diseases, is that indeed"},{"speaker":"Eduardo Bravo","startTime":1006.41,"endTime":1013.55,"body":"NETs are the initiators and the"},{"speaker":"Eduardo Bravo","startTime":1013.55,"endTime":1016.49,"body":"key components of the"},{"speaker":"Eduardo Bravo","startTime":1013.55,"endTime":1016.49,"body":"inflammation, and we can target"},{"speaker":"Eduardo Bravo","startTime":1016.49,"endTime":1020.51,"body":"those, we believe that we go at"},{"speaker":"Eduardo Bravo","startTime":1016.49,"endTime":1020.51,"body":"the very top of the inflammation"},{"speaker":"Eduardo Bravo","startTime":1020.51,"endTime":1025.01,"body":"cascade, and therefore we should"},{"speaker":"Eduardo Bravo","startTime":1020.51,"endTime":1025.01,"body":"have a much broader"},{"speaker":"Eduardo Bravo","startTime":1025.01,"endTime":1029.675,"body":"applicability than the very"},{"speaker":"Eduardo Bravo","startTime":1025.01,"endTime":1029.675,"body":"specific cytokine targets."},{"speaker":"John Simboli","startTime":1030.635,"endTime":1033.095,"body":"How would you"},{"speaker":"John Simboli","startTime":1030.635,"endTime":1033.095,"body":"describe the function of the"},{"speaker":"John Simboli","startTime":1033.095,"endTime":1035.615,"body":"NET, and why is it foundational?"},{"speaker":"John Simboli","startTime":1035.0,"endTime":1182.36,"body":"Do you find yourself still"},{"speaker":"John Simboli","startTime":1035.0,"endTime":1182.36,"body":"fielding questions, especially"},{"speaker":"Eduardo Bravo","startTime":1035.599,"endTime":1039.07,"body":"So NETs have a"},{"speaker":"Eduardo Bravo","startTime":1035.599,"endTime":1039.07,"body":"pathological, a very important"},{"speaker":"Eduardo Bravo","startTime":1039.147,"endTime":1043.313,"body":"mission. So, you know,"},{"speaker":"Eduardo Bravo","startTime":1039.147,"endTime":1043.313,"body":"neutrophils, which are the most"},{"speaker":"Eduardo Bravo","startTime":1043.39,"endTime":1048.173,"body":"common of the white blood cells,"},{"speaker":"Eduardo Bravo","startTime":1043.39,"endTime":1048.173,"body":"are the first responders to a"},{"speaker":"Eduardo Bravo","startTime":1048.251,"endTime":1052.957,"body":"host attack to the body. And you"},{"speaker":"Eduardo Bravo","startTime":1048.251,"endTime":1052.957,"body":"know, neutrophils respond in"},{"speaker":"Eduardo Bravo","startTime":1053.034,"endTime":1057.74,"body":"four ways, one of which is this"},{"speaker":"Eduardo Bravo","startTime":1053.034,"endTime":1057.74,"body":"NETosis. So it's they sort of"},{"speaker":"Eduardo Bravo","startTime":1057.817,"endTime":1062.214,"body":"explode, if I can say explode,"},{"speaker":"Eduardo Bravo","startTime":1057.817,"endTime":1062.214,"body":"and release their internal"},{"speaker":"Eduardo Bravo","startTime":1062.291,"endTime":1066.534,"body":"content, these web like"},{"speaker":"Eduardo Bravo","startTime":1062.291,"endTime":1066.534,"body":"structures that have, you know,"},{"speaker":"Eduardo Bravo","startTime":1066.612,"endTime":1071.086,"body":"DNA. And those actually are"},{"speaker":"Eduardo Bravo","startTime":1066.612,"endTime":1071.086,"body":"capable, that's the reason why"},{"speaker":"Eduardo Bravo","startTime":1071.163,"endTime":1075.483,"body":"they are called traps, trap"},{"speaker":"Eduardo Bravo","startTime":1071.163,"endTime":1075.483,"body":"these foreign pathogens. And"},{"speaker":"Eduardo Bravo","startTime":1075.561,"endTime":1080.344,"body":"after they have trapped them,"},{"speaker":"Eduardo Bravo","startTime":1075.561,"endTime":1080.344,"body":"they are cleared by macrophages."},{"speaker":"Eduardo Bravo","startTime":1080.421,"endTime":1085.435,"body":"That's the way they should work."},{"speaker":"Eduardo Bravo","startTime":1080.421,"endTime":1085.435,"body":"And we have NETs all over, small"},{"speaker":"Eduardo Bravo","startTime":1085.513,"endTime":1090.373,"body":"amount, because there's always"},{"speaker":"Eduardo Bravo","startTime":1085.513,"endTime":1090.373,"body":"something going on in your body."},{"speaker":"Eduardo Bravo","startTime":1090.45,"endTime":1094.539,"body":"Now, what has been discovered is"},{"speaker":"Eduardo Bravo","startTime":1090.45,"endTime":1094.539,"body":"that in some genetic"},{"speaker":"Eduardo Bravo","startTime":1094.616,"endTime":1099.399,"body":"preconditions in some patients,"},{"speaker":"Eduardo Bravo","startTime":1094.616,"endTime":1099.399,"body":"people have either neutrophils"},{"speaker":"Eduardo Bravo","startTime":1099.476,"endTime":1104.259,"body":"that NETose too easily, or you"},{"speaker":"Eduardo Bravo","startTime":1099.476,"endTime":1104.259,"body":"have an overproduction of NETs."},{"speaker":"Eduardo Bravo","startTime":1104.336,"endTime":1109.12,"body":"One, you have too manyNEs, those"},{"speaker":"Eduardo Bravo","startTime":1104.336,"endTime":1109.12,"body":"NETs accumulate in the tissue"},{"speaker":"Eduardo Bravo","startTime":1109.197,"endTime":1113.594,"body":"and generate tissue damage."},{"speaker":"Eduardo Bravo","startTime":1109.197,"endTime":1113.594,"body":"Because the NETs, apart from,"},{"speaker":"Eduardo Bravo","startTime":1113.671,"endTime":1117.451,"body":"you know, trapping those things,"},{"speaker":"Eduardo Bravo","startTime":1113.671,"endTime":1117.451,"body":"release a lot of"},{"speaker":"Eduardo Bravo","startTime":1117.529,"endTime":1122.389,"body":"pro-inflammatory cytokines. So"},{"speaker":"Eduardo Bravo","startTime":1117.529,"endTime":1122.389,"body":"if you have a continuous release"},{"speaker":"Eduardo Bravo","startTime":1122.466,"endTime":1127.326,"body":"of NETs and accumulation in the"},{"speaker":"Eduardo Bravo","startTime":1122.466,"endTime":1127.326,"body":"NETs, you are actually creating"},{"speaker":"Eduardo Bravo","startTime":1127.403,"endTime":1132.341,"body":"an inflammatory environment. So"},{"speaker":"Eduardo Bravo","startTime":1127.403,"endTime":1132.341,"body":"in a normal, healthy person, you"},{"speaker":"Eduardo Bravo","startTime":1132.418,"endTime":1136.738,"body":"will have some neutrophils"},{"speaker":"Eduardo Bravo","startTime":1132.418,"endTime":1136.738,"body":"netting. And these NETs being"},{"speaker":"Eduardo Bravo","startTime":1136.815,"endTime":1141.676,"body":"healthy for your body, and they"},{"speaker":"Eduardo Bravo","startTime":1136.815,"endTime":1141.676,"body":"will just, you know, clear your"},{"speaker":"Eduardo Bravo","startTime":1141.753,"endTime":1146.304,"body":"pathogens, and they will be"},{"speaker":"Eduardo Bravo","startTime":1141.753,"endTime":1146.304,"body":"eaten by macrophages. But if at"},{"speaker":"Eduardo Bravo","startTime":1146.382,"endTime":1150.393,"body":"some point that regulation is"},{"speaker":"Eduardo Bravo","startTime":1146.382,"endTime":1150.393,"body":"altered, then you have"},{"speaker":"Eduardo Bravo","startTime":1150.47,"endTime":1155.253,"body":"accumulation of NETs, and then"},{"speaker":"Eduardo Bravo","startTime":1150.47,"endTime":1155.253,"body":"an inflammatory process starts,"},{"speaker":"Eduardo Bravo","startTime":1155.331,"endTime":1160.268,"body":"and that inflammation goes into"},{"speaker":"Eduardo Bravo","startTime":1155.331,"endTime":1160.268,"body":"tissue damage, and then you have"},{"speaker":"Eduardo Bravo","startTime":1160.345,"endTime":1165.128,"body":"from chest arthritis to COPD to"},{"speaker":"Eduardo Bravo","startTime":1160.345,"endTime":1165.128,"body":"cardiovascular disease to now,"},{"speaker":"Eduardo Bravo","startTime":1165.205,"endTime":1170.143,"body":"even people are saying this beta"},{"speaker":"Eduardo Bravo","startTime":1165.205,"endTime":1170.143,"body":"in Alzheimer, these plaques are"},{"speaker":"Eduardo Bravo","startTime":1170.22,"endTime":1175.234,"body":"actually coming because of NETs."},{"speaker":"Eduardo Bravo","startTime":1170.22,"endTime":1175.234,"body":"We have now doctors saying that,"},{"speaker":"Eduardo Bravo","startTime":1175.312,"endTime":1180.249,"body":"you know, some of the mechanisms"},{"speaker":"Eduardo Bravo","startTime":1175.312,"endTime":1180.249,"body":"of resistance of tumors have to"},{"speaker":"Eduardo Bravo","startTime":1180.326,"endTime":1184.955,"body":"do with presence of NETs in"},{"speaker":"Eduardo Bravo","startTime":1180.326,"endTime":1184.955,"body":"those tumors. So we're not going"},{"speaker":"Eduardo Bravo","startTime":1182.36,"endTime":1194.75,"body":"in"},{"speaker":"Eduardo Bravo","startTime":1185.032,"endTime":1189.584,"body":"to cure everything. I mean, I"},{"speaker":"Eduardo Bravo","startTime":1185.032,"endTime":1189.584,"body":"think that we need to be very"},{"speaker":"Eduardo Bravo","startTime":1189.661,"endTime":1194.058,"body":"realistic. But what is amazing"},{"speaker":"Eduardo Bravo","startTime":1189.661,"endTime":1194.058,"body":"is that something that was"},{"speaker":"Eduardo Bravo","startTime":1194.135,"endTime":1198.764,"body":"unknown 20 years ago, today"},{"speaker":"Eduardo Bravo","startTime":1194.135,"endTime":1198.764,"body":"there's plenty of literature and"},{"speaker":"Eduardo Bravo","startTime":1198.841,"endTime":1203.702,"body":"every day there's new literature"},{"speaker":"Eduardo Bravo","startTime":1198.841,"endTime":1203.702,"body":"linking NETs to more diseases,"},{"speaker":"Eduardo Bravo","startTime":1203.779,"endTime":1208.408,"body":"all of inflammatory component."},{"speaker":"Eduardo Bravo","startTime":1203.779,"endTime":1208.408,"body":"Now, the link that we need to"},{"speaker":"Eduardo Bravo","startTime":1208.485,"endTime":1213.114,"body":"do, and that's the hypothesis,"},{"speaker":"Eduardo Bravo","startTime":1208.485,"endTime":1213.114,"body":"is that by reducing the NETs,"},{"speaker":"Eduardo Bravo","startTime":1213.191,"endTime":1215.66,"body":"you will have a clinical effect."},{"speaker":"Eduardo Bravo","startTime":1217.145,"endTime":1231.185,"body":"The question that I get the most"},{"speaker":"Eduardo Bravo","startTime":1217.145,"endTime":1231.185,"body":"is like, How sure are you that"},{"speaker":"Eduardo Bravo","startTime":1231.185,"endTime":1235.445,"body":"the NETs are the cause and not"},{"speaker":"Eduardo Bravo","startTime":1231.185,"endTime":1235.445,"body":"the consequence of the"},{"speaker":"Eduardo Bravo","startTime":1235.445,"endTime":1238.745,"body":"inflammation? We call it"},{"speaker":"Eduardo Bravo","startTime":1235.445,"endTime":1238.745,"body":"informally, the chicken and egg"},{"speaker":"Eduardo Bravo","startTime":1238.985,"endTime":1242.21,"body":"problem. Well, I think that we"},{"speaker":"Eduardo Bravo","startTime":1238.985,"endTime":1242.21,"body":"have more and more data that we"},{"speaker":"Eduardo Bravo","startTime":1242.21,"endTime":1246.59,"body":"believe shows that they are the"},{"speaker":"Eduardo Bravo","startTime":1242.21,"endTime":1246.59,"body":"initial and that, you know, they"},{"speaker":"Eduardo Bravo","startTime":1246.59,"endTime":1250.55,"body":"are a cause. Clearly, there's"},{"speaker":"Eduardo Bravo","startTime":1246.59,"endTime":1250.55,"body":"very little or no data to show"},{"speaker":"Eduardo Bravo","startTime":1250.55,"endTime":1254.87,"body":"that you can have a clinical"},{"speaker":"Eduardo Bravo","startTime":1250.55,"endTime":1254.87,"body":"effect by touching NETs. That's"},{"speaker":"Eduardo Bravo","startTime":1254.99,"endTime":1258.41,"body":"what remains to be seen. We've"},{"speaker":"Eduardo Bravo","startTime":1254.99,"endTime":1258.41,"body":"done it in animals, but now we"},{"speaker":"Eduardo Bravo","startTime":1258.41,"endTime":1261.53,"body":"need to do it in patients. No"},{"speaker":"Eduardo Bravo","startTime":1258.41,"endTime":1261.53,"body":"one has been able, I mean,"},{"speaker":"Eduardo Bravo","startTime":1261.53,"endTime":1268.295,"body":"there's been some older tries."},{"speaker":"Eduardo Bravo","startTime":1261.53,"endTime":1268.295,"body":"The NETs are created when"},{"speaker":"Eduardo Bravo","startTime":1268.355,"endTime":1272.555,"body":"through the PAD4 inhibitor,"},{"speaker":"Eduardo Bravo","startTime":1268.355,"endTime":1272.555,"body":"enzyme. And I don't know if you"},{"speaker":"Eduardo Bravo","startTime":1272.555,"endTime":1277.955,"body":"remember, but a few years ago,"},{"speaker":"Eduardo Bravo","startTime":1272.555,"endTime":1277.955,"body":"this PAD4 became super hot, and"},{"speaker":"Eduardo Bravo","startTime":1277.955,"endTime":1281.555,"body":"BMS, I think, acquired Padlock."},{"speaker":"Eduardo Bravo","startTime":1277.955,"endTime":1281.555,"body":"So it was, you know, there was a"},{"speaker":"Eduardo Bravo","startTime":1281.555,"endTime":1285.155,"body":"couple of very big acquisitions,"},{"speaker":"Eduardo Bravo","startTime":1281.555,"endTime":1285.155,"body":"and two or three big pharmas had"},{"speaker":"Eduardo Bravo","startTime":1285.155,"endTime":1290.12,"body":"these PAD4 inhibitor programs,"},{"speaker":"Eduardo Bravo","startTime":1285.155,"endTime":1290.12,"body":"because it was a small molecule,"},{"speaker":"Eduardo Bravo","startTime":1290.36,"endTime":1295.28,"body":"and you could actually eliminate"},{"speaker":"Eduardo Bravo","startTime":1290.36,"endTime":1295.28,"body":"NETosis by not allowing these"},{"speaker":"Eduardo Bravo","startTime":1295.28,"endTime":1298.76,"body":"NETs to explode inside the"},{"speaker":"Eduardo Bravo","startTime":1295.28,"endTime":1298.76,"body":"neutrophil. So that was the"},{"speaker":"Eduardo Bravo","startTime":1298.76,"endTime":1302.36,"body":"idea, you don't allow the"},{"speaker":"Eduardo Bravo","startTime":1298.76,"endTime":1302.36,"body":"decondensation of the DNA, and"},{"speaker":"Eduardo Bravo","startTime":1302.36,"endTime":1305.54,"body":"therefore the neutrophil does"},{"speaker":"Eduardo Bravo","startTime":1302.36,"endTime":1305.54,"body":"not explode. I still think that"},{"speaker":"Eduardo Bravo","startTime":1305.54,"endTime":1309.38,"body":"they will be missing the"},{"speaker":"Eduardo Bravo","startTime":1305.54,"endTime":1309.38,"body":"clearing of the NETs, but that's"},{"speaker":"Eduardo Bravo","startTime":1309.38,"endTime":1312.305,"body":"a different story. That was the"},{"speaker":"Eduardo Bravo","startTime":1309.38,"endTime":1312.305,"body":"idea. So there was a lot of"},{"speaker":"Eduardo Bravo","startTime":1312.305,"endTime":1315.305,"body":"interest. Now, the problem with"},{"speaker":"Eduardo Bravo","startTime":1312.305,"endTime":1315.305,"body":"those small molecules is that"},{"speaker":"Eduardo Bravo","startTime":1315.305,"endTime":1321.005,"body":"PAD4 is an intracellular target"},{"speaker":"Eduardo Bravo","startTime":1315.305,"endTime":1321.005,"body":"that touches many other things"},{"speaker":"Eduardo Bravo","startTime":1321.065,"endTime":1325.565,"body":"on top of this, you know, DNA,"},{"speaker":"Eduardo Bravo","startTime":1321.065,"endTime":1325.565,"body":"the condensation of the"},{"speaker":"Eduardo Bravo","startTime":1325.565,"endTime":1329.585,"body":"neutrophils, and therefore are"},{"speaker":"Eduardo Bravo","startTime":1325.565,"endTime":1329.585,"body":"very toxic. There's some people"},{"speaker":"Eduardo Bravo","startTime":1329.585,"endTime":1333.89,"body":"now, AstraZeneca has an antibody"},{"speaker":"Eduardo Bravo","startTime":1329.585,"endTime":1333.89,"body":"against PAD4. So it shows that"},{"speaker":"Eduardo Bravo","startTime":1333.89,"endTime":1336.95,"body":"some companies have not"},{"speaker":"Eduardo Bravo","startTime":1333.89,"endTime":1336.95,"body":"abandoned it completely. But"},{"speaker":"Eduardo Bravo","startTime":1336.95,"endTime":1340.85,"body":"it's very, very early stage, but"},{"speaker":"Eduardo Bravo","startTime":1336.95,"endTime":1340.85,"body":"it's still no one has been able"},{"speaker":"Eduardo Bravo","startTime":1340.85,"endTime":1345.89,"body":"to target these NETs. We're the"},{"speaker":"Eduardo Bravo","startTime":1340.85,"endTime":1345.89,"body":"first one. So, you know, people"},{"speaker":"Eduardo Bravo","startTime":1345.89,"endTime":1350.27,"body":"were interested. We've seen some"},{"speaker":"Eduardo Bravo","startTime":1345.89,"endTime":1350.27,"body":"big pharmas that have come to us"},{"speaker":"Eduardo Bravo","startTime":1350.27,"endTime":1353.39,"body":"and like, wow, we really like"},{"speaker":"Eduardo Bravo","startTime":1350.27,"endTime":1353.39,"body":"this approach, we really like"},{"speaker":"Eduardo Bravo","startTime":1353.39,"endTime":1357.395,"body":"this NET idea, but we've never"},{"speaker":"Eduardo Bravo","startTime":1353.39,"endTime":1357.395,"body":"been able to target. You know,"},{"speaker":"Eduardo Bravo","startTime":1357.395,"endTime":1361.715,"body":"those pharmas, some became"},{"speaker":"Eduardo Bravo","startTime":1357.395,"endTime":1361.715,"body":"investors, some are probably are"},{"speaker":"Eduardo Bravo","startTime":1361.715,"endTime":1365.435,"body":"looking into the data, will be"},{"speaker":"Eduardo Bravo","startTime":1361.715,"endTime":1365.435,"body":"looking into the data. Because"},{"speaker":"Eduardo Bravo","startTime":1365.435,"endTime":1367.655,"body":"also, when you go with a new"},{"speaker":"Eduardo Bravo","startTime":1365.435,"endTime":1367.655,"body":"mechanism of action, there's"},{"speaker":"Eduardo Bravo","startTime":1367.655,"endTime":1370.895,"body":"still a lot of unknowns. Is the"},{"speaker":"Eduardo Bravo","startTime":1367.655,"endTime":1370.895,"body":"dose sufficient, you know, what"},{"speaker":"Eduardo Bravo","startTime":1370.895,"endTime":1375.035,"body":"is the right regimen, what is"},{"speaker":"Eduardo Bravo","startTime":1370.895,"endTime":1375.035,"body":"the right indication, what is"},{"speaker":"Eduardo Bravo","startTime":1375.035,"endTime":1377.855,"body":"the right patient, what is . . ."},{"speaker":"Eduardo Bravo","startTime":1375.035,"endTime":1377.855,"body":"So I understand the risk"},{"speaker":"Eduardo Bravo","startTime":1377.855,"endTime":1382.52,"body":"associated, but for me, this is"},{"speaker":"Eduardo Bravo","startTime":1377.855,"endTime":1382.52,"body":"like an anti TNF Alpha when they"},{"speaker":"Eduardo Bravo","startTime":1382.52,"endTime":1388.22,"body":"arrived, a PD-1. I mean, I think"},{"speaker":"Eduardo Bravo","startTime":1382.52,"endTime":1388.22,"body":"that this, if our hypothesis is"},{"speaker":"Eduardo Bravo","startTime":1388.22,"endTime":1393.2,"body":"right, this will unlock a new"},{"speaker":"Eduardo Bravo","startTime":1388.22,"endTime":1393.2,"body":"category of anti-inflammatory"},{"speaker":"Eduardo Bravo","startTime":1393.0,"endTime":1398.249,"body":"I will call it"},{"speaker":"Eduardo Bravo","startTime":1393.0,"endTime":1398.249,"body":"like this. Probably the phrase"},{"speaker":"Eduardo Bravo","startTime":1393.2,"endTime":1393.56,"body":"agents."},{"speaker":"John Simboli","startTime":1393.5,"endTime":1396.291,"body":"At very beginning,"},{"speaker":"John Simboli","startTime":1393.5,"endTime":1396.291,"body":"you were saying that one of the"},{"speaker":"John Simboli","startTime":1396.347,"endTime":1399.418,"body":"attractions for you about"},{"speaker":"John Simboli","startTime":1396.347,"endTime":1399.418,"body":"Citryll was that, in a sense,"},{"speaker":"John Simboli","startTime":1398.366,"endTime":1405.482,"body":"that I will hear the most would"},{"speaker":"John Simboli","startTime":1398.366,"endTime":1405.482,"body":"be, we remain to be convinced"},{"speaker":"John Simboli","startTime":1399.474,"endTime":1402.825,"body":"it's a simple idea. It's not"},{"speaker":"John Simboli","startTime":1399.474,"endTime":1402.825,"body":"hard to grasp, not easy to find"},{"speaker":"John Simboli","startTime":1402.881,"endTime":1406.343,"body":"out if it's right or wrong. But"},{"speaker":"John Simboli","startTime":1402.881,"endTime":1406.343,"body":"the concept, I think you said,"},{"speaker":"John Simboli","startTime":1405.598,"endTime":1412.831,"body":"that by reducing NETs, you will"},{"speaker":"John Simboli","startTime":1405.598,"endTime":1412.831,"body":"have a clinical effect. That's"},{"speaker":"John Simboli","startTime":1406.398,"endTime":1409.525,"body":"was not difficult to grasp. My"},{"speaker":"John Simboli","startTime":1406.398,"endTime":1409.525,"body":"guess is that an investor"},{"speaker":"John Simboli","startTime":1409.581,"endTime":1412.485,"body":"conferences and other places"},{"speaker":"John Simboli","startTime":1409.581,"endTime":1412.485,"body":"where you're talking to"},{"speaker":"John Simboli","startTime":1412.541,"endTime":1416.003,"body":"sophisticated audiences, that"},{"speaker":"John Simboli","startTime":1412.541,"endTime":1416.003,"body":"there are times when people hear"},{"speaker":"John Simboli","startTime":1412.948,"endTime":1420.297,"body":"the reason why we're doing two"},{"speaker":"John Simboli","startTime":1412.948,"endTime":1420.297,"body":"clinical trials. In two clinical"},{"speaker":"John Simboli","startTime":1416.059,"endTime":1419.577,"body":"what you're saying, what you've"},{"speaker":"John Simboli","startTime":1416.059,"endTime":1419.577,"body":"been saying to me over the last"},{"speaker":"John Simboli","startTime":1419.632,"endTime":1423.094,"body":"half hour or so, and and decide"},{"speaker":"John Simboli","startTime":1419.632,"endTime":1423.094,"body":"that they see you as this kind"},{"speaker":"John Simboli","startTime":1420.414,"endTime":1427.88,"body":"trials, and if it works in both,"},{"speaker":"John Simboli","startTime":1420.414,"endTime":1427.88,"body":"but we will need to show it. No"},{"speaker":"John Simboli","startTime":1423.15,"endTime":1426.78,"body":"of company, or someone else sees"},{"speaker":"John Simboli","startTime":1423.15,"endTime":1426.78,"body":"you as that kind of company. You"},{"speaker":"John Simboli","startTime":1426.836,"endTime":1430.242,"body":"know, maybe it's who knows what"},{"speaker":"John Simboli","startTime":1426.836,"endTime":1430.242,"body":"it might be? Can you describe"},{"speaker":"John Simboli","startTime":1427.996,"endTime":1434.879,"body":"one dares to dispute that you"},{"speaker":"John Simboli","startTime":1427.996,"endTime":1434.879,"body":"can give a corticosteroid for"},{"speaker":"John Simboli","startTime":1430.298,"endTime":1433.146,"body":"what categories of"},{"speaker":"John Simboli","startTime":1430.298,"endTime":1433.146,"body":"misunderstanding there are about"},{"speaker":"John Simboli","startTime":1433.201,"endTime":1436.049,"body":"Citryll and then how you go"},{"speaker":"John Simboli","startTime":1433.201,"endTime":1436.049,"body":"about saying, No, we're"},{"speaker":"John Simboli","startTime":1434.996,"endTime":1440.829,"body":"100 indications. What if this"},{"speaker":"John Simboli","startTime":1434.996,"endTime":1440.829,"body":"was the 21st century"},{"speaker":"John Simboli","startTime":1436.105,"endTime":1438.06,"body":"actually, this is what we're about?"},{"speaker":"John Simboli","startTime":1440.945,"endTime":1448.178,"body":"corticosteroid without the side"},{"speaker":"John Simboli","startTime":1440.945,"endTime":1448.178,"body":"effects of the corticosteroid?"},{"speaker":"John Simboli","startTime":1448.295,"endTime":1454.594,"body":"If really NETs are this"},{"speaker":"John Simboli","startTime":1448.295,"endTime":1454.594,"body":"important, and we could really"},{"speaker":"John Simboli","startTime":1454.711,"endTime":1461.71,"body":"eliminate excess NETs in the"},{"speaker":"John Simboli","startTime":1454.711,"endTime":1461.71,"body":"body?  That's the maximum. Yes,"},{"speaker":"John Simboli","startTime":1461.827,"endTime":1468.709,"body":"but I don't think that RA is the"},{"speaker":"John Simboli","startTime":1461.827,"endTime":1468.709,"body":"only area. We're doing RA,"},{"speaker":"John Simboli","startTime":1462.645,"endTime":1492.57,"body":"How does the"},{"speaker":"John Simboli","startTime":1462.645,"endTime":1492.57,"body":"Citryll platform and pipeline"},{"speaker":"John Simboli","startTime":1468.826,"endTime":1475.592,"body":"because it would be very easy"},{"speaker":"John Simboli","startTime":1468.826,"endTime":1475.592,"body":"for pharmas and investors to"},{"speaker":"John Simboli","startTime":1475.709,"endTime":1482.825,"body":"understand that there's not a"},{"speaker":"John Simboli","startTime":1475.709,"endTime":1482.825,"body":"single compound that works only"},{"speaker":"John Simboli","startTime":1482.941,"endTime":1488.658,"body":"in RA. If it works in RA, it"},{"speaker":"John Simboli","startTime":1482.941,"endTime":1488.658,"body":"works in at least 10"},{"speaker":"John Simboli","startTime":1488.774,"endTime":1495.89,"body":"indications. Once you've crossed"},{"speaker":"John Simboli","startTime":1488.774,"endTime":1495.89,"body":"that bridge, a lot of people"},{"speaker":"John Simboli","startTime":1492.93,"endTime":1508.335,"body":"express your vision for the"},{"speaker":"John Simboli","startTime":1492.93,"endTime":1508.335,"body":"company?"},{"speaker":"John Simboli","startTime":1496.007,"endTime":1503.94,"body":"will see this very differently,"},{"speaker":"John Simboli","startTime":1496.007,"endTime":1503.94,"body":"and that's reason why we went there."},{"speaker":"Eduardo Bravo","startTime":1508.78,"endTime":1512.5,"body":"The vision is to"},{"speaker":"Eduardo Bravo","startTime":1508.78,"endTime":1512.5,"body":"bring something to the market as"},{"speaker":"Eduardo Bravo","startTime":1512.5,"endTime":1516.7,"body":"quickly as possible that really"},{"speaker":"Eduardo Bravo","startTime":1512.5,"endTime":1516.7,"body":"makes a difference for patients."},{"speaker":"Eduardo Bravo","startTime":1517.06,"endTime":1521.02,"body":"And you know, if it's a, you"},{"speaker":"Eduardo Bravo","startTime":1517.06,"endTime":1521.02,"body":"know, the new corticosteroids of"},{"speaker":"Eduardo Bravo","startTime":1521.02,"endTime":1524.56,"body":"the future, fine, if it's a"},{"speaker":"Eduardo Bravo","startTime":1521.02,"endTime":1524.56,"body":"super-targeted approach for a"},{"speaker":"Eduardo Bravo","startTime":1524.56,"endTime":1530.8,"body":"sub-population of HS. But we"},{"speaker":"Eduardo Bravo","startTime":1524.56,"endTime":1530.8,"body":"need to find out which patients"},{"speaker":"Eduardo Bravo","startTime":1530.8,"endTime":1534.985,"body":"will benefit and how quickly we"},{"speaker":"Eduardo Bravo","startTime":1530.8,"endTime":1534.985,"body":"can get the compound out for"},{"speaker":"Eduardo Bravo","startTime":1534.985,"endTime":1537.025,"body":"those patients. That's my goal."},{"speaker":"John Simboli","startTime":1536.98,"endTime":1539.777,"body":"Many people"},{"speaker":"John Simboli","startTime":1536.98,"endTime":1539.777,"body":"listening will have a working"},{"speaker":"John Simboli","startTime":1539.845,"endTime":1544.006,"body":"understanding of what RA is. Can"},{"speaker":"John Simboli","startTime":1539.845,"endTime":1544.006,"body":"you help with describing HS?"},{"speaker":"John Simboli","startTime":1544.074,"endTime":1548.1,"body":"What do patients have to deal"},{"speaker":"John Simboli","startTime":1544.074,"endTime":1548.1,"body":"with? What's their life like?"},{"speaker":"Eduardo Bravo","startTime":1548.0,"endTime":1549.8,"body":"Hidradenitis"},{"speaker":"Eduardo Bravo","startTime":1548.0,"endTime":1549.8,"body":"Suppurativa, which is the"},{"speaker":"Eduardo Bravo","startTime":1549.8,"endTime":1553.94,"body":"horrible name, and that's reason"},{"speaker":"Eduardo Bravo","startTime":1549.8,"endTime":1553.94,"body":"why it's now called HS. And"},{"speaker":"Eduardo Bravo","startTime":1554.06,"endTime":1557.84,"body":"three years ago, no one knew"},{"speaker":"Eduardo Bravo","startTime":1554.06,"endTime":1557.84,"body":"what HS meant, not even in our"},{"speaker":"Eduardo Bravo","startTime":1557.84,"endTime":1562.76,"body":"sector. But now the arrival of"},{"speaker":"Eduardo Bravo","startTime":1557.84,"endTime":1562.76,"body":"the IL-17, Cosentyx and BimZelx"},{"speaker":"Eduardo Bravo","startTime":1563.12,"endTime":1566.9,"body":"and others in development has"},{"speaker":"Eduardo Bravo","startTime":1563.12,"endTime":1566.9,"body":"transformed the market. So now"},{"speaker":"Eduardo Bravo","startTime":1567.26,"endTime":1571.325,"body":"all the investors, everyone"},{"speaker":"Eduardo Bravo","startTime":1567.26,"endTime":1571.325,"body":"understands HS. But HS is a"},{"speaker":"Eduardo Bravo","startTime":1571.325,"endTime":1574.025,"body":"neutrophilic disease in which"},{"speaker":"Eduardo Bravo","startTime":1571.325,"endTime":1574.025,"body":"you have an infection that"},{"speaker":"Eduardo Bravo","startTime":1574.025,"endTime":1578.825,"body":"usually starts n the follicle. I"},{"speaker":"Eduardo Bravo","startTime":1574.025,"endTime":1578.825,"body":"would say, gets out of control,"},{"speaker":"Eduardo Bravo","startTime":1578.825,"endTime":1583.205,"body":"and you end up with, in the"},{"speaker":"Eduardo Bravo","startTime":1578.825,"endTime":1583.205,"body":"armpits, in between your legs,"},{"speaker":"Eduardo Bravo","startTime":1583.205,"endTime":1587.645,"body":"under your breast, in the areas"},{"speaker":"Eduardo Bravo","startTime":1583.205,"endTime":1587.645,"body":"of friction, you end up with"},{"speaker":"Eduardo Bravo","startTime":1587.825,"endTime":1594.71,"body":"huge abscesses and scars and"},{"speaker":"Eduardo Bravo","startTime":1587.825,"endTime":1594.71,"body":"tunnels and superation, which"},{"speaker":"Eduardo Bravo","startTime":1594.71,"endTime":1600.29,"body":"means that smells, I mean, it's"},{"speaker":"Eduardo Bravo","startTime":1594.71,"endTime":1600.29,"body":"very, very debilitating. You"},{"speaker":"Eduardo Bravo","startTime":1600.29,"endTime":1603.71,"body":"don't die of HS, but people"},{"speaker":"Eduardo Bravo","startTime":1600.29,"endTime":1603.71,"body":"have, you know, a lot of"},{"speaker":"Eduardo Bravo","startTime":1603.71,"endTime":1608.21,"body":"difficulty in living with it. It"},{"speaker":"Eduardo Bravo","startTime":1603.71,"endTime":1608.21,"body":"takes ages now, hopefully it"},{"speaker":"Eduardo Bravo","startTime":1608.21,"endTime":1612.83,"body":"will be quicker for GPs to"},{"speaker":"Eduardo Bravo","startTime":1608.21,"endTime":1612.83,"body":"recognize it and to treat it"},{"speaker":"Eduardo Bravo","startTime":1612.83,"endTime":1616.67,"body":"correctly. And now, with the"},{"speaker":"Eduardo Bravo","startTime":1612.83,"endTime":1616.67,"body":"IL-17 is starting to change, but"},{"speaker":"Eduardo Bravo","startTime":1616.67,"endTime":1621.095,"body":"up until now, with very little"},{"speaker":"Eduardo Bravo","startTime":1616.67,"endTime":1621.095,"body":"effective treatment available,"},{"speaker":"Eduardo Bravo","startTime":1621.095,"endTime":1625.715,"body":"so patients had to endure those"},{"speaker":"Eduardo Bravo","startTime":1621.095,"endTime":1625.715,"body":"therapies going through surgery"},{"speaker":"Eduardo Bravo","startTime":1625.715,"endTime":1630.215,"body":"when the area was, you know, too"},{"speaker":"Eduardo Bravo","startTime":1625.715,"endTime":1630.215,"body":"damaged, and so you have scars,"},{"speaker":"Eduardo Bravo","startTime":1630.335,"endTime":1632.915,"body":"you know, you don't want to show"},{"speaker":"Eduardo Bravo","startTime":1630.335,"endTime":1632.915,"body":"your body. I mean, it's a"},{"speaker":"Eduardo Bravo","startTime":1633.875,"endTime":1635.915,"body":"tremendously debilitating"},{"speaker":"Eduardo Bravo","startTime":1633.875,"endTime":1635.915,"body":"disease."},{"speaker":"John Simboli","startTime":1636.08,"endTime":1639.2,"body":"How was it that"},{"speaker":"John Simboli","startTime":1636.08,"endTime":1639.2,"body":"Citryll chose to be located in"},{"speaker":"John Simboli","startTime":1639.2,"endTime":1640.4,"body":"Oss and the Netherlands?"},{"speaker":"Eduardo Bravo","startTime":1640.0,"endTime":1642.94,"body":"The company was"},{"speaker":"Eduardo Bravo","startTime":1640.0,"endTime":1642.94,"body":"started in Oss. It's where"},{"speaker":"Eduardo Bravo","startTime":1642.94,"endTime":1647.5,"body":"Organon was founded. And you"},{"speaker":"Eduardo Bravo","startTime":1642.94,"endTime":1647.5,"body":"know, that's where Keytruda was"},{"speaker":"Eduardo Bravo","startTime":1647.5,"endTime":1652.0,"body":"discovered, because Keytruda is"},{"speaker":"Eduardo Bravo","startTime":1647.5,"endTime":1652.0,"body":"originally an Organon compound,"},{"speaker":"Eduardo Bravo","startTime":1652.54,"endTime":1657.76,"body":"is where the PTK of Acerta,"},{"speaker":"Eduardo Bravo","startTime":1652.54,"endTime":1657.76,"body":"Acerta is there. So there's a"},{"speaker":"Eduardo Bravo","startTime":1657.76,"endTime":1662.02,"body":"couple of very big drugs already"},{"speaker":"Eduardo Bravo","startTime":1657.76,"endTime":1662.02,"body":"that have come out of of the"},{"speaker":"Eduardo Bravo","startTime":1662.02,"endTime":1665.245,"body":"research in Oss. There's"},{"speaker":"Eduardo Bravo","startTime":1662.02,"endTime":1665.245,"body":"probably 50 or 60 biotech"},{"speaker":"Eduardo Bravo","startTime":1665.245,"endTime":1669.565,"body":"companies there, So it's a very"},{"speaker":"Eduardo Bravo","startTime":1665.245,"endTime":1669.565,"body":"small location, but there's like"},{"speaker":"Eduardo Bravo","startTime":1669.565,"endTime":1672.505,"body":"a small hub. I think that that's"},{"speaker":"Eduardo Bravo","startTime":1669.565,"endTime":1672.505,"body":"what is impressive about the"},{"speaker":"Eduardo Bravo","startTime":1672.505,"endTime":1677.845,"body":"Benelux in general, is, you know"},{"speaker":"Eduardo Bravo","startTime":1672.505,"endTime":1677.845,"body":"how good they are at moving"},{"speaker":"Eduardo Bravo","startTime":1678.325,"endTime":1681.505,"body":"compounds and companies and"},{"speaker":"Eduardo Bravo","startTime":1678.325,"endTime":1681.505,"body":"funding them, and you know, the"},{"speaker":"Eduardo Bravo","startTime":1681.505,"endTime":1683.665,"body":"science is great, and the"},{"speaker":"Eduardo Bravo","startTime":1681.505,"endTime":1683.665,"body":"founders are great, and there"},{"speaker":"Eduardo Bravo","startTime":1683.665,"endTime":1687.97,"body":"are teams there. And so, you"},{"speaker":"Eduardo Bravo","startTime":1683.665,"endTime":1687.97,"body":"know, all my respect for those"},{"speaker":"Eduardo Bravo","startTime":1687.97,"endTime":1691.15,"body":"countries, I think, in how they"},{"speaker":"Eduardo Bravo","startTime":1687.97,"endTime":1691.15,"body":"are developing the industry."},{"speaker":"John Simboli","startTime":1691.99,"endTime":1693.97,"body":"Eduardo, thanks"},{"speaker":"John Simboli","startTime":1691.99,"endTime":1693.97,"body":"for speaking with me today."},{"speaker":"Eduardo Bravo","startTime":1694.27,"endTime":1696.49,"body":"Thank you, John."},{"speaker":"Eduardo Bravo","startTime":1694.27,"endTime":1696.49,"body":"It was a real pleasure."}]}