{"version":"1.0.0","segments":[{"speaker":"John Simboli","startTime":0.0,"endTime":1.68,"body":"Bruce, welcome to"},{"speaker":"John Simboli","startTime":0.0,"endTime":1.68,"body":"BioBoss."},{"speaker":"Bruce Leuchter","startTime":2.0,"endTime":3.38,"body":"Thanks, John,"},{"speaker":"Bruce Leuchter","startTime":2.0,"endTime":3.38,"body":"pleasure to be here."},{"speaker":"John Simboli","startTime":3.38,"endTime":6.32,"body":"Bruce, what led"},{"speaker":"John Simboli","startTime":3.38,"endTime":6.32,"body":"you to your role as cofounder"},{"speaker":"John Simboli","startTime":6.32,"endTime":8.96,"body":"and CEO of Neurvati"},{"speaker":"John Simboli","startTime":6.32,"endTime":8.96,"body":"Neurosciences?"},{"speaker":"Bruce Leuchter","startTime":9.24,"endTime":12.66,"body":"It draws on a"},{"speaker":"Bruce Leuchter","startTime":9.24,"endTime":12.66,"body":"number of different experiences"},{"speaker":"Bruce Leuchter","startTime":12.66,"endTime":16.02,"body":"that I've had over the course of"},{"speaker":"Bruce Leuchter","startTime":12.66,"endTime":16.02,"body":"my career. And, you know, I grew"},{"speaker":"Bruce Leuchter","startTime":16.02,"endTime":19.2,"body":"up in the home of a brilliant"},{"speaker":"Bruce Leuchter","startTime":16.02,"endTime":19.2,"body":"clinician-scientist neurologist,"},{"speaker":"Bruce Leuchter","startTime":19.32,"endTime":22.62,"body":"found my way into neurology"},{"speaker":"Bruce Leuchter","startTime":19.32,"endTime":22.62,"body":"residency, then did some"},{"speaker":"Bruce Leuchter","startTime":22.62,"endTime":25.8,"body":"training in psychiatry, because"},{"speaker":"Bruce Leuchter","startTime":22.62,"endTime":25.8,"body":"I felt like I was getting half"},{"speaker":"Bruce Leuchter","startTime":25.8,"endTime":29.16,"body":"the story. So doing both"},{"speaker":"Bruce Leuchter","startTime":25.8,"endTime":29.16,"body":"neurology and psychiatry"},{"speaker":"Bruce Leuchter","startTime":29.16,"endTime":32.94,"body":"broadened my horizons around"},{"speaker":"Bruce Leuchter","startTime":29.16,"endTime":32.94,"body":"thinking through issues related"},{"speaker":"Bruce Leuchter","startTime":32.94,"endTime":38.145,"body":"to the brain and nervous system."},{"speaker":"Bruce Leuchter","startTime":32.94,"endTime":38.145,"body":"And from there, I believed that"},{"speaker":"Bruce Leuchter","startTime":38.145,"endTime":42.585,"body":"understanding industry, and as"},{"speaker":"Bruce Leuchter","startTime":38.145,"endTime":42.585,"body":"part of that, financial services"},{"speaker":"Bruce Leuchter","startTime":42.585,"endTime":47.265,"body":"in healthcare and biotech, would"},{"speaker":"Bruce Leuchter","startTime":42.585,"endTime":47.265,"body":"create another dimension to the"},{"speaker":"Bruce Leuchter","startTime":47.265,"endTime":51.885,"body":"work that I had done to date,"},{"speaker":"Bruce Leuchter","startTime":47.265,"endTime":51.885,"body":"but use the scientific and"},{"speaker":"Bruce Leuchter","startTime":51.885,"endTime":55.245,"body":"clinical perspective, and"},{"speaker":"Bruce Leuchter","startTime":51.885,"endTime":55.245,"body":"frankly, my love of those two"},{"speaker":"Bruce Leuchter","startTime":55.83,"endTime":58.95,"body":"dimensions of my life, the"},{"speaker":"Bruce Leuchter","startTime":55.83,"endTime":58.95,"body":"scientific training and clinical"},{"speaker":"Bruce Leuchter","startTime":58.95,"endTime":63.27,"body":"experience to inform how I"},{"speaker":"Bruce Leuchter","startTime":58.95,"endTime":63.27,"body":"performed my role in the"},{"speaker":"Bruce Leuchter","startTime":63.27,"endTime":67.17,"body":"financial services sector. And"},{"speaker":"Bruce Leuchter","startTime":63.27,"endTime":67.17,"body":"it was always a third leg of the"},{"speaker":"Bruce Leuchter","startTime":67.17,"endTime":72.75,"body":"stool to be able to leverage all"},{"speaker":"Bruce Leuchter","startTime":67.17,"endTime":72.75,"body":"of that in actually operating a"},{"speaker":"Bruce Leuchter","startTime":72.75,"endTime":75.21,"body":"neuroscience-focused biotech"},{"speaker":"Bruce Leuchter","startTime":72.75,"endTime":75.21,"body":"company. I think there's no"},{"speaker":"Bruce Leuchter","startTime":75.21,"endTime":78.315,"body":"greater privilege beyond,"},{"speaker":"Bruce Leuchter","startTime":75.21,"endTime":78.315,"body":"perhaps, taking care of patients"},{"speaker":"Bruce Leuchter","startTime":78.315,"endTime":82.215,"body":"that one can have than"},{"speaker":"Bruce Leuchter","startTime":78.315,"endTime":82.215,"body":"developing a novel therapy for a"},{"speaker":"Bruce Leuchter","startTime":82.215,"endTime":86.235,"body":"disease with high unmet medical"},{"speaker":"Bruce Leuchter","startTime":82.215,"endTime":86.235,"body":"need. And that is our mandate at"},{"speaker":"Bruce Leuchter","startTime":86.235,"endTime":90.195,"body":"Neurvati, and we get to do it"},{"speaker":"Bruce Leuchter","startTime":86.235,"endTime":90.195,"body":"with best-in-class sponsors,"},{"speaker":"Bruce Leuchter","startTime":90.195,"endTime":94.155,"body":"financial partners who help us"},{"speaker":"Bruce Leuchter","startTime":90.195,"endTime":94.155,"body":"along the way. And that's"},{"speaker":"Bruce Leuchter","startTime":94.155,"endTime":97.695,"body":"ultimately what led to me"},{"speaker":"Bruce Leuchter","startTime":94.155,"endTime":97.695,"body":"sitting in this seat, which, as"},{"speaker":"Bruce Leuchter","startTime":97.695,"endTime":100.095,"body":"we'll talk about, I'm sure later"},{"speaker":"Bruce Leuchter","startTime":97.695,"endTime":100.095,"body":"on in the discussion, has some"},{"speaker":"Bruce Leuchter","startTime":100.155,"endTime":104.16,"body":"unique features to it that draw,"},{"speaker":"Bruce Leuchter","startTime":100.155,"endTime":104.16,"body":"in particular, on the number of"},{"speaker":"Bruce Leuchter","startTime":104.16,"endTime":106.92,"body":"different professional"},{"speaker":"Bruce Leuchter","startTime":104.16,"endTime":106.92,"body":"experiences I've had over time"},{"speaker":"John Simboli","startTime":106.22,"endTime":109.4,"body":"When you were"},{"speaker":"John Simboli","startTime":106.22,"endTime":109.4,"body":"thinking about that, how you"},{"speaker":"John Simboli","startTime":109.4,"endTime":113.78,"body":"would apply your background and"},{"speaker":"John Simboli","startTime":109.4,"endTime":113.78,"body":"your interest in, and seeing how"},{"speaker":"John Simboli","startTime":113.78,"endTime":118.22,"body":"it could turn into, perhaps, a"},{"speaker":"John Simboli","startTime":113.78,"endTime":118.22,"body":"therapy someday, you must have"},{"speaker":"John Simboli","startTime":118.22,"endTime":120.98,"body":"looked at a lot of different"},{"speaker":"John Simboli","startTime":118.22,"endTime":120.98,"body":"options and a lot of different"},{"speaker":"John Simboli","startTime":120.98,"endTime":124.925,"body":"possibilities. How did you land"},{"speaker":"John Simboli","startTime":120.98,"endTime":124.925,"body":"on the one that enabled you to"},{"speaker":"John Simboli","startTime":124.925,"endTime":126.065,"body":"become the co-founder?"},{"speaker":"Bruce Leuchter","startTime":126.3,"endTime":129.78,"body":"Well, I think we"},{"speaker":"Bruce Leuchter","startTime":126.3,"endTime":129.78,"body":"in biotech often find ourselves"},{"speaker":"Bruce Leuchter","startTime":129.78,"endTime":135.18,"body":"looking across the landscape of"},{"speaker":"Bruce Leuchter","startTime":129.78,"endTime":135.18,"body":"opportunities. And in many"},{"speaker":"Bruce Leuchter","startTime":135.18,"endTime":139.08,"body":"cases, particularly in the"},{"speaker":"Bruce Leuchter","startTime":135.18,"endTime":139.08,"body":"venture world, you find early"},{"speaker":"Bruce Leuchter","startTime":139.08,"endTime":141.96,"body":"stage science, perhaps coming"},{"speaker":"Bruce Leuchter","startTime":139.08,"endTime":141.96,"body":"out of a top tier academic"},{"speaker":"Bruce Leuchter","startTime":141.96,"endTime":147.0,"body":"institution, or pre-clinical"},{"speaker":"Bruce Leuchter","startTime":141.96,"endTime":147.0,"body":"assets, molecules that are in"},{"speaker":"Bruce Leuchter","startTime":147.36,"endTime":149.444,"body":"development, pre-clinically that"},{"speaker":"Bruce Leuchter","startTime":147.36,"endTime":149.444,"body":"haven't yet found their way to"},{"speaker":"Bruce Leuchter","startTime":149.444,"endTime":151.845,"body":"the clinic. And then you work"},{"speaker":"Bruce Leuchter","startTime":149.444,"endTime":151.845,"body":"your way downstream and find"},{"speaker":"Bruce Leuchter","startTime":151.845,"endTime":155.205,"body":"clinical data sets around which"},{"speaker":"Bruce Leuchter","startTime":151.845,"endTime":155.205,"body":"you can organize for"},{"speaker":"Bruce Leuchter","startTime":155.205,"endTime":159.045,"body":"opportunities that exist in the"},{"speaker":"Bruce Leuchter","startTime":155.205,"endTime":159.045,"body":"market. And for our investors,"},{"speaker":"Bruce Leuchter","startTime":159.045,"endTime":161.685,"body":"Blackstone Life Sciences, the"},{"speaker":"Bruce Leuchter","startTime":159.045,"endTime":161.685,"body":"clinical data is really"},{"speaker":"Bruce Leuchter","startTime":161.685,"endTime":166.845,"body":"important, and it's important"},{"speaker":"Bruce Leuchter","startTime":161.685,"endTime":166.845,"body":"because we focus our efforts on"},{"speaker":"Bruce Leuchter","startTime":166.905,"endTime":170.085,"body":"mid and late stage drug"},{"speaker":"Bruce Leuchter","startTime":166.905,"endTime":170.085,"body":"development, where often"},{"speaker":"Bruce Leuchter","startTime":170.085,"endTime":174.285,"body":"companies find themselves in"},{"speaker":"Bruce Leuchter","startTime":170.085,"endTime":174.285,"body":"various different circumstances"},{"speaker":"Bruce Leuchter","startTime":174.285,"endTime":178.59,"body":"that preclude progressing"},{"speaker":"Bruce Leuchter","startTime":174.285,"endTime":178.59,"body":"programs internally and require"},{"speaker":"Bruce Leuchter","startTime":178.65,"endTime":181.29,"body":"externalizing those programs,"},{"speaker":"Bruce Leuchter","startTime":178.65,"endTime":181.29,"body":"putting them in the hands of"},{"speaker":"Bruce Leuchter","startTime":181.83,"endTime":186.87,"body":"entrepreneurs who, in our"},{"speaker":"Bruce Leuchter","startTime":181.83,"endTime":186.87,"body":"circumstance, have the necessary"},{"speaker":"Bruce Leuchter","startTime":186.87,"endTime":189.75,"body":"amount of capital to finance,"},{"speaker":"Bruce Leuchter","startTime":186.87,"endTime":189.75,"body":"they've been in late stage"},{"speaker":"Bruce Leuchter","startTime":189.75,"endTime":194.49,"body":"development. So for us, while"},{"speaker":"Bruce Leuchter","startTime":189.75,"endTime":194.49,"body":"there is a ton of raw material"},{"speaker":"Bruce Leuchter","startTime":194.49,"endTime":195.075,"body":"out there, early stage"},{"speaker":"Bruce Leuchter","startTime":194.49,"endTime":195.075,"body":"technologies that hold a"},{"speaker":"Bruce Leuchter","startTime":195.075,"endTime":199.755,"body":"tremendous amount of promise,"},{"speaker":"Bruce Leuchter","startTime":195.075,"endTime":199.755,"body":"our mandate is one where we need"},{"speaker":"Bruce Leuchter","startTime":199.755,"endTime":202.515,"body":"to look at mid and late stage"},{"speaker":"Bruce Leuchter","startTime":199.755,"endTime":202.515,"body":"development, and there are some"},{"speaker":"Bruce Leuchter","startTime":202.515,"endTime":205.395,"body":"unique challenges associated"},{"speaker":"Bruce Leuchter","startTime":202.515,"endTime":205.395,"body":"with that. Neuroscience is a"},{"speaker":"Bruce Leuchter","startTime":205.395,"endTime":209.715,"body":"space that has a pretty"},{"speaker":"Bruce Leuchter","startTime":205.395,"endTime":209.715,"body":"significant capital requirement"},{"speaker":"Bruce Leuchter","startTime":209.715,"endTime":212.355,"body":"to develop drugs through"},{"speaker":"Bruce Leuchter","startTime":209.715,"endTime":212.355,"body":"approval. Timelines can"},{"speaker":"Bruce Leuchter","startTime":212.355,"endTime":216.075,"body":"sometimes be more prolonged than"},{"speaker":"Bruce Leuchter","startTime":212.355,"endTime":216.075,"body":"other therapeutic areas, and"},{"speaker":"Bruce Leuchter","startTime":216.075,"endTime":220.26,"body":"risk is quite high. And it's not"},{"speaker":"Bruce Leuchter","startTime":216.075,"endTime":220.26,"body":"without understanding all of"},{"speaker":"Bruce Leuchter","startTime":220.26,"endTime":222.9,"body":"those things that people make"},{"speaker":"Bruce Leuchter","startTime":220.26,"endTime":222.9,"body":"decisions around neuroscience,"},{"speaker":"Bruce Leuchter","startTime":223.02,"endTime":227.04,"body":"product candidates, and for us,"},{"speaker":"Bruce Leuchter","startTime":223.02,"endTime":227.04,"body":"focusing on that later stage of"},{"speaker":"Bruce Leuchter","startTime":227.04,"endTime":229.5,"body":"development where we can"},{"speaker":"Bruce Leuchter","startTime":227.04,"endTime":229.5,"body":"organize around data, clinical"},{"speaker":"Bruce Leuchter","startTime":229.5,"endTime":233.16,"body":"data and pre-clinical data that"},{"speaker":"Bruce Leuchter","startTime":229.5,"endTime":233.16,"body":"give us conviction, is critical"},{"speaker":"Bruce Leuchter","startTime":233.16,"endTime":238.32,"body":"to getting a new affiliate co"},{"speaker":"Bruce Leuchter","startTime":233.16,"endTime":238.32,"body":"over the finish line and in our"},{"speaker":"Bruce Leuchter","startTime":238.98,"endTime":241.605,"body":"first affiliate co, GRIN"},{"speaker":"Bruce Leuchter","startTime":238.98,"endTime":241.605,"body":"Therapeutics, that fact pattern"},{"speaker":"Bruce Leuchter","startTime":241.605,"endTime":244.965,"body":"existed. We had a molecule that"},{"speaker":"Bruce Leuchter","startTime":241.605,"endTime":244.965,"body":"had a significant amount of"},{"speaker":"Bruce Leuchter","startTime":244.965,"endTime":248.385,"body":"clinical data, had a whole lot"},{"speaker":"Bruce Leuchter","startTime":244.965,"endTime":248.385,"body":"for us to look at in terms of"},{"speaker":"Bruce Leuchter","startTime":248.385,"endTime":252.705,"body":"safety, tolerability, dosing,"},{"speaker":"Bruce Leuchter","startTime":248.385,"endTime":252.705,"body":"protocol, PK, and even data in"},{"speaker":"Bruce Leuchter","startTime":252.705,"endTime":255.645,"body":"certain neuroscience"},{"speaker":"Bruce Leuchter","startTime":252.705,"endTime":255.645,"body":"indications. And when we coupled"},{"speaker":"Bruce Leuchter","startTime":255.645,"endTime":259.905,"body":"that with GRIN related"},{"speaker":"Bruce Leuchter","startTime":255.645,"endTime":259.905,"body":"neurodevelopmental disorder and"},{"speaker":"Bruce Leuchter","startTime":259.905,"endTime":263.925,"body":"knew that we could use human"},{"speaker":"Bruce Leuchter","startTime":259.905,"endTime":263.925,"body":"genetics to identify the most"},{"speaker":"Bruce Leuchter","startTime":263.925,"endTime":267.51,"body":"appropriate patient to enroll in"},{"speaker":"Bruce Leuchter","startTime":263.925,"endTime":267.51,"body":"our study, and combine that with"},{"speaker":"Bruce Leuchter","startTime":267.51,"endTime":270.21,"body":"the dossier that we had around"},{"speaker":"Bruce Leuchter","startTime":267.51,"endTime":270.21,"body":"this program, it made a whole"},{"speaker":"Bruce Leuchter","startTime":270.21,"endTime":274.29,"body":"lot of sense to push off on this"},{"speaker":"Bruce Leuchter","startTime":270.21,"endTime":274.29,"body":"particular opportunity, and"},{"speaker":"Bruce Leuchter","startTime":274.29,"endTime":275.67,"body":"we've been at it now for four"},{"speaker":"Bruce Leuchter","startTime":274.29,"endTime":275.67,"body":"years."},{"speaker":"John Simboli","startTime":275.66,"endTime":278.78,"body":"Does your work put"},{"speaker":"John Simboli","startTime":275.66,"endTime":278.78,"body":"you at the head of GRIN and"},{"speaker":"John Simboli","startTime":278.78,"endTime":279.44,"body":"Neurvati?"},{"speaker":"Bruce Leuchter","startTime":280.6,"endTime":284.86,"body":"So Neurvati"},{"speaker":"Bruce Leuchter","startTime":280.6,"endTime":284.86,"body":"Neurosciences is an operating"},{"speaker":"Bruce Leuchter","startTime":284.86,"endTime":289.18,"body":"company, a development company"},{"speaker":"Bruce Leuchter","startTime":284.86,"endTime":289.18,"body":"that is owned by Blackstone Life"},{"speaker":"Bruce Leuchter","startTime":289.18,"endTime":294.16,"body":"Sciences, and it was created to"},{"speaker":"Bruce Leuchter","startTime":289.18,"endTime":294.16,"body":"work on neuroscience"},{"speaker":"Bruce Leuchter","startTime":294.16,"endTime":297.4,"body":"therapeutics across the"},{"speaker":"Bruce Leuchter","startTime":294.16,"endTime":297.4,"body":"waterfront, which means that"},{"speaker":"Bruce Leuchter","startTime":297.4,"endTime":300.1,"body":"we're not restricted to a"},{"speaker":"Bruce Leuchter","startTime":297.4,"endTime":300.1,"body":"particular vertical in"},{"speaker":"Bruce Leuchter","startTime":300.1,"endTime":302.86,"body":"neuroscience. So as an example,"},{"speaker":"Bruce Leuchter","startTime":300.1,"endTime":302.86,"body":"right now, GRIN Therapeutics is"},{"speaker":"Bruce Leuchter","startTime":302.86,"endTime":305.845,"body":"focused on neurodevelopmental"},{"speaker":"Bruce Leuchter","startTime":302.86,"endTime":305.845,"body":"disease, but we look at"},{"speaker":"Bruce Leuchter","startTime":305.845,"endTime":310.105,"body":"opportunities that are in the"},{"speaker":"Bruce Leuchter","startTime":305.845,"endTime":310.105,"body":"clinic with critical mass data"},{"speaker":"Bruce Leuchter","startTime":310.105,"endTime":312.685,"body":"that could be in the neuro"},{"speaker":"Bruce Leuchter","startTime":310.105,"endTime":312.685,"body":"oncology space, could be in the"},{"speaker":"Bruce Leuchter","startTime":312.685,"endTime":314.725,"body":"neurovascular space,"},{"speaker":"Bruce Leuchter","startTime":312.685,"endTime":314.725,"body":"neuromuscular space,"},{"speaker":"Bruce Leuchter","startTime":314.725,"endTime":317.725,"body":"neuroinflammatory disease space,"},{"speaker":"Bruce Leuchter","startTime":314.725,"endTime":317.725,"body":"neuropsychiatry, pain, sleep,"},{"speaker":"Bruce Leuchter","startTime":317.725,"endTime":323.005,"body":"wake. All of these verticals for"},{"speaker":"Bruce Leuchter","startTime":317.725,"endTime":323.005,"body":"us are options, and the lowest"},{"speaker":"Bruce Leuchter","startTime":323.005,"endTime":327.25,"body":"common denominator is whether or"},{"speaker":"Bruce Leuchter","startTime":323.005,"endTime":327.25,"body":"not there's enough data to"},{"speaker":"Bruce Leuchter","startTime":327.25,"endTime":331.39,"body":"support a highly convicted view"},{"speaker":"Bruce Leuchter","startTime":327.25,"endTime":331.39,"body":"around success in mid and late"},{"speaker":"Bruce Leuchter","startTime":331.39,"endTime":336.13,"body":"stage development and regulatory"},{"speaker":"Bruce Leuchter","startTime":331.39,"endTime":336.13,"body":"discussions. So what Neurvati"},{"speaker":"Bruce Leuchter","startTime":336.13,"endTime":339.01,"body":"does is operate those affiliate"},{"speaker":"Bruce Leuchter","startTime":336.13,"endTime":339.01,"body":"co's, and that's where the"},{"speaker":"Bruce Leuchter","startTime":339.01,"endTime":342.13,"body":"people sit, the human capital,"},{"speaker":"Bruce Leuchter","startTime":339.01,"endTime":342.13,"body":"but all of the action, or"},{"speaker":"Bruce Leuchter","startTime":342.13,"endTime":345.67,"body":"activity, if you will, exists at"},{"speaker":"Bruce Leuchter","startTime":342.13,"endTime":345.67,"body":"the affiliate co level. The"},{"speaker":"Bruce Leuchter","startTime":345.73,"endTime":349.93,"body":"Neurvati team drops down into"},{"speaker":"Bruce Leuchter","startTime":345.73,"endTime":349.93,"body":"that affiliate co and executes."},{"speaker":"Bruce Leuchter","startTime":350.23,"endTime":353.455,"body":"So all of the functions that"},{"speaker":"Bruce Leuchter","startTime":350.23,"endTime":353.455,"body":"you'd ordinarily expect to see"},{"speaker":"Bruce Leuchter","startTime":353.515,"endTime":356.875,"body":"within a biotech company"},{"speaker":"Bruce Leuchter","startTime":353.515,"endTime":356.875,"body":"certainly exist. They exist at"},{"speaker":"Bruce Leuchter","startTime":356.875,"endTime":361.915,"body":"the Neurvati co level, and then"},{"speaker":"Bruce Leuchter","startTime":356.875,"endTime":361.915,"body":"the day-to-day execution occurs"},{"speaker":"Bruce Leuchter","startTime":361.915,"endTime":364.855,"body":"in the affiliate co. And that's"},{"speaker":"Bruce Leuchter","startTime":361.915,"endTime":364.855,"body":"where the asset sits, that's"},{"speaker":"Bruce Leuchter","startTime":364.855,"endTime":368.035,"body":"where the capital flows when we"},{"speaker":"Bruce Leuchter","startTime":364.855,"endTime":368.035,"body":"raise capital. That's where the"},{"speaker":"Bruce Leuchter","startTime":368.035,"endTime":372.055,"body":"governance sits, where the"},{"speaker":"Bruce Leuchter","startTime":368.035,"endTime":372.055,"body":"incentive structure sits. And it"},{"speaker":"Bruce Leuchter","startTime":372.1,"endTime":377.38,"body":"allows us, as Neurvati, to"},{"speaker":"Bruce Leuchter","startTime":372.1,"endTime":377.38,"body":"continue to progress this sort"},{"speaker":"Bruce Leuchter","startTime":377.38,"endTime":380.44,"body":"of work across a number of"},{"speaker":"Bruce Leuchter","startTime":377.38,"endTime":380.44,"body":"different projects going"},{"speaker":"Bruce Leuchter","startTime":380.44,"endTime":383.32,"body":"forward. But the project that we"},{"speaker":"Bruce Leuchter","startTime":380.44,"endTime":383.32,"body":"have in hand right now, that"},{"speaker":"Bruce Leuchter","startTime":383.32,"endTime":387.94,"body":"we're solely focused on is GRIN,"},{"speaker":"Bruce Leuchter","startTime":383.32,"endTime":387.94,"body":"GRIN related neurodevelopmental"},{"speaker":"Bruce Leuchter","startTime":387.94,"endTime":391.54,"body":"disorder, and the development of"},{"speaker":"Bruce Leuchter","startTime":387.94,"endTime":391.54,"body":"radiprodil to treat these kids"},{"speaker":"Bruce Leuchter","startTime":391.54,"endTime":395.68,"body":"with a really difficult and"},{"speaker":"Bruce Leuchter","startTime":391.54,"endTime":395.68,"body":"highly morbid disease process."},{"speaker":"Bruce Leuchter","startTime":396.1,"endTime":401.545,"body":"When we look at opportunities,"},{"speaker":"Bruce Leuchter","startTime":396.1,"endTime":401.545,"body":"we are focused on human"},{"speaker":"Bruce Leuchter","startTime":401.545,"endTime":405.265,"body":"genetics. We want to have"},{"speaker":"Bruce Leuchter","startTime":401.545,"endTime":405.265,"body":"clarity around the patient"},{"speaker":"Bruce Leuchter","startTime":405.265,"endTime":408.565,"body":"population that suffers from the"},{"speaker":"Bruce Leuchter","startTime":405.265,"endTime":408.565,"body":"disease, how we can identify"},{"speaker":"Bruce Leuchter","startTime":408.565,"endTime":412.105,"body":"those patients, definitively"},{"speaker":"Bruce Leuchter","startTime":408.565,"endTime":412.105,"body":"diagnose those patients, and"},{"speaker":"Bruce Leuchter","startTime":412.105,"endTime":417.608,"body":"deliver precision therapeutics"},{"speaker":"Bruce Leuchter","startTime":412.105,"endTime":417.608,"body":"to those patients. People define"},{"speaker":"Bruce Leuchter","startTime":417.608,"endTime":417.987,"body":"precision therapeutics in"},{"speaker":"Bruce Leuchter","startTime":417.608,"endTime":417.987,"body":"various different ways, with"},{"speaker":"Bruce Leuchter","startTime":417.987,"endTime":420.01,"body":"various different therapeutic"},{"speaker":"Bruce Leuchter","startTime":417.987,"endTime":420.01,"body":"modalities. But the bottom line"},{"speaker":"Bruce Leuchter","startTime":420.01,"endTime":424.75,"body":"is that we're aiming to use"},{"speaker":"Bruce Leuchter","startTime":420.01,"endTime":424.75,"body":"human genetics, biomarkers of"},{"speaker":"Bruce Leuchter","startTime":424.75,"endTime":428.05,"body":"all sorts, whether they are from"},{"speaker":"Bruce Leuchter","startTime":424.75,"endTime":428.05,"body":"the cerebral spinal fluid,"},{"speaker":"Bruce Leuchter","startTime":428.17,"endTime":430.81,"body":"whether they are imaging"},{"speaker":"Bruce Leuchter","startTime":428.17,"endTime":430.81,"body":"biomarkers, electrophysiologic"},{"speaker":"Bruce Leuchter","startTime":430.81,"endTime":434.11,"body":"biomarkers, to try to"},{"speaker":"Bruce Leuchter","startTime":430.81,"endTime":434.11,"body":"triangulate around the patient"},{"speaker":"Bruce Leuchter","startTime":434.11,"endTime":437.53,"body":"population that is best suited"},{"speaker":"Bruce Leuchter","startTime":434.11,"endTime":437.53,"body":"to enroll in a study and to"},{"speaker":"Bruce Leuchter","startTime":437.53,"endTime":440.65,"body":"potentially benefit from an"},{"speaker":"Bruce Leuchter","startTime":437.53,"endTime":440.65,"body":"experimental therapy, should it"},{"speaker":"Bruce Leuchter","startTime":440.65,"endTime":443.875,"body":"get approved. And that's exactly"},{"speaker":"Bruce Leuchter","startTime":440.65,"endTime":443.875,"body":"what we did with GRIN. We said"},{"speaker":"Bruce Leuchter","startTime":443.935,"endTime":446.695,"body":"there's a genetically defined"},{"speaker":"Bruce Leuchter","startTime":443.935,"endTime":446.695,"body":"disease in GRIN related"},{"speaker":"Bruce Leuchter","startTime":446.695,"endTime":449.395,"body":"neurodevelopmental disorder."},{"speaker":"Bruce Leuchter","startTime":446.695,"endTime":449.395,"body":"There are no drugs approved to"},{"speaker":"Bruce Leuchter","startTime":449.395,"endTime":452.155,"body":"treat that disease. There are"},{"speaker":"Bruce Leuchter","startTime":449.395,"endTime":452.155,"body":"drugs approved to treat some of"},{"speaker":"Bruce Leuchter","startTime":452.155,"endTime":454.975,"body":"the symptoms of that disease,"},{"speaker":"Bruce Leuchter","startTime":452.155,"endTime":454.975,"body":"but no drugs approved to treat"},{"speaker":"Bruce Leuchter","startTime":454.975,"endTime":459.475,"body":"the underlying biology of that"},{"speaker":"Bruce Leuchter","startTime":454.975,"endTime":459.475,"body":"disease. So we can add a lot of"},{"speaker":"Bruce Leuchter","startTime":459.475,"endTime":463.075,"body":"value to patients, families and"},{"speaker":"Bruce Leuchter","startTime":459.475,"endTime":463.075,"body":"caregivers, that's key. But we"},{"speaker":"Bruce Leuchter","startTime":463.075,"endTime":465.28,"body":"also want to make sure that"},{"speaker":"Bruce Leuchter","startTime":463.075,"endTime":465.28,"body":"we're going to succeed as best"},{"speaker":"Bruce Leuchter","startTime":465.28,"endTime":468.76,"body":"we can, as best as one can when"},{"speaker":"Bruce Leuchter","startTime":465.28,"endTime":468.76,"body":"you're developing novel"},{"speaker":"Bruce Leuchter","startTime":468.76,"endTime":472.96,"body":"therapies. So how do we do that?"},{"speaker":"Bruce Leuchter","startTime":468.76,"endTime":472.96,"body":"We look at these triangulation"},{"speaker":"Bruce Leuchter","startTime":473.2,"endTime":477.82,"body":"exercises. In our case, GRIN, it"},{"speaker":"Bruce Leuchter","startTime":473.2,"endTime":477.82,"body":"was human genetics, and we"},{"speaker":"Bruce Leuchter","startTime":477.82,"endTime":481.12,"body":"developed conviction around our"},{"speaker":"Bruce Leuchter","startTime":477.82,"endTime":481.12,"body":"ability to identify these"},{"speaker":"Bruce Leuchter","startTime":481.12,"endTime":484.96,"body":"patients, properly diagnose"},{"speaker":"Bruce Leuchter","startTime":481.12,"endTime":484.96,"body":"them, and enrich the patient"},{"speaker":"Bruce Leuchter","startTime":484.96,"endTime":488.005,"body":"population that we enroll into"},{"speaker":"Bruce Leuchter","startTime":484.96,"endTime":488.005,"body":"the study. And that gives us a"},{"speaker":"Bruce Leuchter","startTime":488.005,"endTime":493.225,"body":"higher probability of showing a"},{"speaker":"Bruce Leuchter","startTime":488.005,"endTime":493.225,"body":"more impactful clinical effect"},{"speaker":"Bruce Leuchter","startTime":493.525,"endTime":496.105,"body":"that will drive even more"},{"speaker":"Bruce Leuchter","startTime":493.525,"endTime":496.105,"body":"conviction as we head into"},{"speaker":"Bruce Leuchter","startTime":496.105,"endTime":498.265,"body":"pivotal studies, which, of"},{"speaker":"Bruce Leuchter","startTime":496.105,"endTime":498.265,"body":"course, is what we're doing"},{"speaker":"Bruce Leuchter","startTime":498.265,"endTime":503.125,"body":"right now. So we knew the"},{"speaker":"Bruce Leuchter","startTime":498.265,"endTime":503.125,"body":"biology made sense. We knew the"},{"speaker":"Bruce Leuchter","startTime":503.125,"endTime":505.585,"body":"mechanistic rationale made"},{"speaker":"Bruce Leuchter","startTime":503.125,"endTime":505.585,"body":"sense, and we knew we could"},{"speaker":"Bruce Leuchter","startTime":505.585,"endTime":508.945,"body":"leverage pretty significantly"},{"speaker":"Bruce Leuchter","startTime":505.585,"endTime":508.945,"body":"human genetics to get us to a"},{"speaker":"Bruce Leuchter","startTime":508.945,"endTime":512.59,"body":"better spot. Historically in the"},{"speaker":"Bruce Leuchter","startTime":508.945,"endTime":512.59,"body":"treatment of these sorts of"},{"speaker":"Bruce Leuchter","startTime":512.59,"endTime":515.89,"body":"diseases, they're often called"},{"speaker":"Bruce Leuchter","startTime":512.59,"endTime":515.89,"body":"developmental epileptic"},{"speaker":"Bruce Leuchter","startTime":515.89,"endTime":519.91,"body":"encephalopathies, or DEEs, or"},{"speaker":"Bruce Leuchter","startTime":515.89,"endTime":519.91,"body":"neurodevelopmental disorders, or"},{"speaker":"Bruce Leuchter","startTime":519.91,"endTime":524.59,"body":"NDDs. Typically, you found"},{"speaker":"Bruce Leuchter","startTime":519.91,"endTime":524.59,"body":"companies developing symptomatic"},{"speaker":"Bruce Leuchter","startTime":524.59,"endTime":527.59,"body":"treatments. So there may be"},{"speaker":"Bruce Leuchter","startTime":524.59,"endTime":527.59,"body":"seizures that are a component"},{"speaker":"Bruce Leuchter","startTime":527.59,"endTime":530.59,"body":"part of the disease, they're"},{"speaker":"Bruce Leuchter","startTime":527.59,"endTime":530.59,"body":"developing an anti-epileptic or"},{"speaker":"Bruce Leuchter","startTime":530.59,"endTime":533.515,"body":"anti-seizure medicine to treat"},{"speaker":"Bruce Leuchter","startTime":530.59,"endTime":533.515,"body":"those seizures. There may be"},{"speaker":"Bruce Leuchter","startTime":533.515,"endTime":538.195,"body":"behavioral symptoms, and doctors"},{"speaker":"Bruce Leuchter","startTime":533.515,"endTime":538.195,"body":"may use psychotropic medicines"},{"speaker":"Bruce Leuchter","startTime":538.195,"endTime":540.655,"body":"to manage behavioral"},{"speaker":"Bruce Leuchter","startTime":538.195,"endTime":540.655,"body":"dysregulation, but they're"},{"speaker":"Bruce Leuchter","startTime":540.655,"endTime":544.855,"body":"treating the symptom. And what"},{"speaker":"Bruce Leuchter","startTime":540.655,"endTime":544.855,"body":"we thought we could do was"},{"speaker":"Bruce Leuchter","startTime":544.915,"endTime":547.795,"body":"organize around rapiprodil, a"},{"speaker":"Bruce Leuchter","startTime":544.915,"endTime":547.795,"body":"negative allosteric modulator"},{"speaker":"Bruce Leuchter","startTime":547.795,"endTime":552.055,"body":"against the NR2B subunit of the"},{"speaker":"Bruce Leuchter","startTime":547.795,"endTime":552.055,"body":"NMDA receptor, do it in patients"},{"speaker":"Bruce Leuchter","startTime":552.055,"endTime":555.835,"body":"who we definitively know have"},{"speaker":"Bruce Leuchter","startTime":552.055,"endTime":555.835,"body":"hyperactivity at that receptor,"},{"speaker":"Bruce Leuchter","startTime":555.835,"endTime":559.36,"body":"given a gain of function"},{"speaker":"Bruce Leuchter","startTime":555.835,"endTime":559.36,"body":"mutation, and potentially drive"},{"speaker":"Bruce Leuchter","startTime":559.36,"endTime":564.22,"body":"outsized effect in those"},{"speaker":"Bruce Leuchter","startTime":559.36,"endTime":564.22,"body":"patients. And we did that in a"},{"speaker":"Bruce Leuchter","startTime":564.22,"endTime":569.2,"body":"phase 1b/2A study, a small 15"},{"speaker":"Bruce Leuchter","startTime":564.22,"endTime":569.2,"body":"patient open label data set. But"},{"speaker":"Bruce Leuchter","startTime":569.2,"endTime":572.74,"body":"the data were so compelling, so"},{"speaker":"Bruce Leuchter","startTime":569.2,"endTime":572.74,"body":"convincing, that despite it"},{"speaker":"Bruce Leuchter","startTime":572.74,"endTime":575.8,"body":"being open label and a small"},{"speaker":"Bruce Leuchter","startTime":572.74,"endTime":575.8,"body":"number of patients, gave all"},{"speaker":"Bruce Leuchter","startTime":575.8,"endTime":578.74,"body":"stakeholders conviction around"},{"speaker":"Bruce Leuchter","startTime":575.8,"endTime":578.74,"body":"the potential therapeutic"},{"speaker":"Bruce Leuchter","startTime":578.74,"endTime":582.685,"body":"candidate. And so we feel like"},{"speaker":"Bruce Leuchter","startTime":578.74,"endTime":582.685,"body":"we've gotten to a mile marker in"},{"speaker":"Bruce Leuchter","startTime":582.685,"endTime":586.165,"body":"the course of our life cycle,"},{"speaker":"Bruce Leuchter","startTime":582.685,"endTime":586.165,"body":"where we've been able to prove"},{"speaker":"Bruce Leuchter","startTime":586.165,"endTime":589.945,"body":"out the thesis, where one can"},{"speaker":"Bruce Leuchter","startTime":586.165,"endTime":589.945,"body":"identify an opportunity that"},{"speaker":"Bruce Leuchter","startTime":589.945,"endTime":593.365,"body":"exists within another company,"},{"speaker":"Bruce Leuchter","startTime":589.945,"endTime":593.365,"body":"do a whole bunch of work to"},{"speaker":"Bruce Leuchter","startTime":593.365,"endTime":596.965,"body":"convince ourselves that it's"},{"speaker":"Bruce Leuchter","startTime":593.365,"endTime":596.965,"body":"worthy of the commitment that"},{"speaker":"Bruce Leuchter","startTime":596.965,"endTime":601.285,"body":"we're aiming to make. License it"},{"speaker":"Bruce Leuchter","startTime":596.965,"endTime":601.285,"body":"in, or acquire the asset in"},{"speaker":"Bruce Leuchter","startTime":601.285,"endTime":604.15,"body":"develop a special purpose"},{"speaker":"Bruce Leuchter","startTime":601.285,"endTime":604.15,"body":"vehicle around it, and that's"},{"speaker":"Bruce Leuchter","startTime":604.15,"endTime":608.83,"body":"GRIN Therapeutics, and then"},{"speaker":"Bruce Leuchter","startTime":604.15,"endTime":608.83,"body":"deliver on data that gives the"},{"speaker":"Bruce Leuchter","startTime":608.83,"endTime":612.01,"body":"broader community conviction"},{"speaker":"Bruce Leuchter","startTime":608.83,"endTime":612.01,"body":"around the potential of the drug"},{"speaker":"Bruce Leuchter","startTime":612.01,"endTime":614.83,"body":"candidate. And now here we are"},{"speaker":"Bruce Leuchter","startTime":612.01,"endTime":614.83,"body":"having done that with GRIN. And"},{"speaker":"Bruce Leuchter","startTime":615.01,"endTime":618.73,"body":"the aim for Neurvati would be to"},{"speaker":"Bruce Leuchter","startTime":615.01,"endTime":618.73,"body":"reproduce that success across"},{"speaker":"Bruce Leuchter","startTime":619.03,"endTime":622.93,"body":"another affiliate co, and, you"},{"speaker":"Bruce Leuchter","startTime":619.03,"endTime":622.93,"body":"know, continue to create a"},{"speaker":"Bruce Leuchter","startTime":622.93,"endTime":628.495,"body":"flywheel and become a solution"},{"speaker":"Bruce Leuchter","startTime":622.93,"endTime":628.495,"body":"for neuroscience therapeutic"},{"speaker":"Bruce Leuchter","startTime":628.495,"endTime":631.915,"body":"development, which I'd argue,"},{"speaker":"Bruce Leuchter","startTime":628.495,"endTime":631.915,"body":"and I think most would in this"},{"speaker":"Bruce Leuchter","startTime":631.915,"endTime":635.335,"body":"space, needs solutions, given"},{"speaker":"Bruce Leuchter","startTime":631.915,"endTime":635.335,"body":"the challenges that are inherent"},{"speaker":"Bruce Leuchter","startTime":635.335,"endTime":639.535,"body":"in developing drugs in this"},{"speaker":"Bruce Leuchter","startTime":635.335,"endTime":639.535,"body":"space. There needs to be ways to"},{"speaker":"Bruce Leuchter","startTime":639.535,"endTime":644.455,"body":"get creative around how to take"},{"speaker":"Bruce Leuchter","startTime":639.535,"endTime":644.455,"body":"viable technology, resource it"},{"speaker":"Bruce Leuchter","startTime":644.455,"endTime":647.635,"body":"appropriately, and deliver it to"},{"speaker":"Bruce Leuchter","startTime":644.455,"endTime":647.635,"body":"patients and caregivers. And"},{"speaker":"Bruce Leuchter","startTime":647.635,"endTime":649.375,"body":"that's what we're built to do."},{"speaker":"John Simboli","startTime":649.375,"endTime":651.52,"body":"In that early"},{"speaker":"John Simboli","startTime":649.375,"endTime":651.52,"body":"stage, before you knew you had"},{"speaker":"John Simboli","startTime":651.52,"endTime":658.06,"body":"traction, an inkling and the"},{"speaker":"John Simboli","startTime":651.52,"endTime":658.06,"body":"data to support it in the early,"},{"speaker":"John Simboli","startTime":658.06,"endTime":661.54,"body":"early stages. Sometimes a"},{"speaker":"John Simboli","startTime":658.06,"endTime":661.54,"body":"founder, CEO, goes through a"},{"speaker":"John Simboli","startTime":661.54,"endTime":664.66,"body":"process of having to leave"},{"speaker":"John Simboli","startTime":661.54,"endTime":664.66,"body":"something that feels secure in"},{"speaker":"John Simboli","startTime":664.66,"endTime":667.66,"body":"order to take on something that"},{"speaker":"John Simboli","startTime":664.66,"endTime":667.66,"body":"feels hopeful."},{"speaker":"Bruce Leuchter","startTime":668.2,"endTime":671.44,"body":"Without"},{"speaker":"Bruce Leuchter","startTime":668.2,"endTime":671.44,"body":"question. And it wasn't a new"},{"speaker":"Bruce Leuchter","startTime":671.44,"endTime":675.82,"body":"kind of conversation for me and"},{"speaker":"Bruce Leuchter","startTime":671.44,"endTime":675.82,"body":"my family. I've had it a number"},{"speaker":"Bruce Leuchter","startTime":675.82,"endTime":681.76,"body":"of times at every mile marker"},{"speaker":"Bruce Leuchter","startTime":675.82,"endTime":681.76,"body":"along the way. One experiences,"},{"speaker":"Bruce Leuchter","startTime":681.76,"endTime":685.54,"body":"inevitably angst, wondering"},{"speaker":"Bruce Leuchter","startTime":681.76,"endTime":685.54,"body":"whether or not the decision is"},{"speaker":"Bruce Leuchter","startTime":685.54,"endTime":689.92,"body":"the right decision. Will it"},{"speaker":"Bruce Leuchter","startTime":685.54,"endTime":689.92,"body":"yield success in the way that"},{"speaker":"Bruce Leuchter","startTime":690.925,"endTime":695.185,"body":"the individual experiences it,"},{"speaker":"Bruce Leuchter","startTime":690.925,"endTime":695.185,"body":"but also in the way that his or"},{"speaker":"Bruce Leuchter","startTime":695.185,"endTime":697.705,"body":"her family experience it."},{"speaker":"Bruce Leuchter","startTime":695.185,"endTime":697.705,"body":"There's change, inevitable"},{"speaker":"Bruce Leuchter","startTime":697.705,"endTime":703.105,"body":"change. And I think change can"},{"speaker":"Bruce Leuchter","startTime":697.705,"endTime":703.105,"body":"be disorganizing, destabilizing,"},{"speaker":"Bruce Leuchter","startTime":703.165,"endTime":707.185,"body":"anxiety provoking, and it"},{"speaker":"Bruce Leuchter","startTime":703.165,"endTime":707.185,"body":"certainly has applied to me and"},{"speaker":"Bruce Leuchter","startTime":707.185,"endTime":709.405,"body":"some of the career decisions"},{"speaker":"Bruce Leuchter","startTime":707.185,"endTime":709.405,"body":"I've made. But what I've always"},{"speaker":"Bruce Leuchter","startTime":709.405,"endTime":715.21,"body":"said along the way to anyone"},{"speaker":"Bruce Leuchter","startTime":709.405,"endTime":715.21,"body":"who's asked, is life is not a"},{"speaker":"Bruce Leuchter","startTime":715.21,"endTime":718.57,"body":"dress rehearsal. You know, this"},{"speaker":"Bruce Leuchter","startTime":715.21,"endTime":718.57,"body":"is the real thing. You've got"},{"speaker":"Bruce Leuchter","startTime":718.57,"endTime":723.97,"body":"one chance and go out, learn as"},{"speaker":"Bruce Leuchter","startTime":718.57,"endTime":723.97,"body":"much as you can, put yourself by"},{"speaker":"Bruce Leuchter","startTime":723.97,"endTime":728.77,"body":"design, in vulnerable positions"},{"speaker":"Bruce Leuchter","startTime":723.97,"endTime":728.77,"body":"where there is clearly risk of"},{"speaker":"Bruce Leuchter","startTime":728.77,"endTime":732.07,"body":"failure, but do it in a"},{"speaker":"Bruce Leuchter","startTime":728.77,"endTime":732.07,"body":"controlled way. Do it in a way"},{"speaker":"Bruce Leuchter","startTime":732.07,"endTime":736.21,"body":"where you've developed enough"},{"speaker":"Bruce Leuchter","startTime":732.07,"endTime":736.21,"body":"muscle mass so that you can"},{"speaker":"Bruce Leuchter","startTime":736.21,"endTime":739.735,"body":"leverage it as you're trying to"},{"speaker":"Bruce Leuchter","startTime":736.21,"endTime":739.735,"body":"bob and weave in the new role."},{"speaker":"Bruce Leuchter","startTime":740.275,"endTime":744.175,"body":"And I would say that it's been"},{"speaker":"Bruce Leuchter","startTime":740.275,"endTime":744.175,"body":"an incredibly enriching"},{"speaker":"Bruce Leuchter","startTime":744.235,"endTime":749.035,"body":"experience to have made the"},{"speaker":"Bruce Leuchter","startTime":744.235,"endTime":749.035,"body":"various different pivots that"},{"speaker":"Bruce Leuchter","startTime":749.035,"endTime":751.975,"body":"I've made, all of which have"},{"speaker":"Bruce Leuchter","startTime":749.035,"endTime":751.975,"body":"come with a certain amount of"},{"speaker":"Bruce Leuchter","startTime":751.975,"endTime":755.995,"body":"anxiety. But therein lies the"},{"speaker":"Bruce Leuchter","startTime":751.975,"endTime":755.995,"body":"learning. And as I look back and"},{"speaker":"Bruce Leuchter","startTime":755.995,"endTime":759.775,"body":"reflect, I couldn't be happier"},{"speaker":"Bruce Leuchter","startTime":755.995,"endTime":759.775,"body":"with the amount that I've been"},{"speaker":"Bruce Leuchter","startTime":759.82,"endTime":763.36,"body":"able to take on board,"},{"speaker":"Bruce Leuchter","startTime":759.82,"endTime":763.36,"body":"synthesize, personalize in my"},{"speaker":"Bruce Leuchter","startTime":763.36,"endTime":769.06,"body":"own way, and then apply to"},{"speaker":"Bruce Leuchter","startTime":763.36,"endTime":769.06,"body":"achieving success with a firm,"},{"speaker":"Bruce Leuchter","startTime":769.18,"endTime":772.96,"body":"with academic colleagues before"},{"speaker":"Bruce Leuchter","startTime":769.18,"endTime":772.96,"body":"I was in the financial services"},{"speaker":"Bruce Leuchter","startTime":772.96,"endTime":776.2,"body":"side of the business and now"},{"speaker":"Bruce Leuchter","startTime":772.96,"endTime":776.2,"body":"with the best in class team. And"},{"speaker":"Bruce Leuchter","startTime":776.2,"endTime":779.68,"body":"assuming ,you know, that"},{"speaker":"Bruce Leuchter","startTime":776.2,"endTime":779.68,"body":"leadership role has a ton of"},{"speaker":"Bruce Leuchter","startTime":779.68,"endTime":783.4,"body":"gravity attached to it. And it"},{"speaker":"Bruce Leuchter","startTime":779.68,"endTime":783.4,"body":"isn't just your own personal"},{"speaker":"Bruce Leuchter","startTime":783.925,"endTime":788.425,"body":"experience and your testing of"},{"speaker":"Bruce Leuchter","startTime":783.925,"endTime":788.425,"body":"your ability to pivot. It's"},{"speaker":"Bruce Leuchter","startTime":789.025,"endTime":792.625,"body":"supporting the company, leading"},{"speaker":"Bruce Leuchter","startTime":789.025,"endTime":792.625,"body":"the organization, creating the"},{"speaker":"Bruce Leuchter","startTime":792.625,"endTime":797.905,"body":"kind of culture, that enables"},{"speaker":"Bruce Leuchter","startTime":792.625,"endTime":797.905,"body":"people to want to sacrifice, to"},{"speaker":"Bruce Leuchter","startTime":797.905,"endTime":802.825,"body":"want to compete, to want to lock"},{"speaker":"Bruce Leuchter","startTime":797.905,"endTime":802.825,"body":"arms, and who believe that one"},{"speaker":"Bruce Leuchter","startTime":802.825,"endTime":805.15,"body":"plus one equals three. And"},{"speaker":"Bruce Leuchter","startTime":802.825,"endTime":805.15,"body":"that's the beauty of a biotech"},{"speaker":"Bruce Leuchter","startTime":805.15,"endTime":810.85,"body":"company, because the expertise"},{"speaker":"Bruce Leuchter","startTime":805.15,"endTime":810.85,"body":"are so diversified across the"},{"speaker":"Bruce Leuchter","startTime":810.85,"endTime":814.03,"body":"team, lots of advanced degree"},{"speaker":"Bruce Leuchter","startTime":810.85,"endTime":814.03,"body":"people, plenty who don't have"},{"speaker":"Bruce Leuchter","startTime":814.03,"endTime":817.15,"body":"advanced degrees, who are"},{"speaker":"Bruce Leuchter","startTime":814.03,"endTime":817.15,"body":"equally as smart and capable and"},{"speaker":"Bruce Leuchter","startTime":817.15,"endTime":821.95,"body":"they have expertise that all"},{"speaker":"Bruce Leuchter","startTime":817.15,"endTime":821.95,"body":"contribute to the ultimate"},{"speaker":"Bruce Leuchter","startTime":821.95,"endTime":826.45,"body":"success of the organization. And"},{"speaker":"Bruce Leuchter","startTime":821.95,"endTime":826.45,"body":"to the earlier comment on data"},{"speaker":"Bruce Leuchter","startTime":826.45,"endTime":831.775,"body":"being binary, you progress"},{"speaker":"Bruce Leuchter","startTime":826.45,"endTime":831.775,"body":"programs for years and years"},{"speaker":"Bruce Leuchter","startTime":831.775,"endTime":837.175,"body":"with countless amounts of"},{"speaker":"Bruce Leuchter","startTime":831.775,"endTime":837.175,"body":"investment dollars, and the fate"},{"speaker":"Bruce Leuchter","startTime":837.175,"endTime":840.655,"body":"of the program oftentimes hinges"},{"speaker":"Bruce Leuchter","startTime":837.175,"endTime":840.655,"body":"on a data point, maybe two,"},{"speaker":"Bruce Leuchter","startTime":840.655,"endTime":843.535,"body":"depending on how many pivotal"},{"speaker":"Bruce Leuchter","startTime":840.655,"endTime":843.535,"body":"studies you're running. Why"},{"speaker":"Bruce Leuchter","startTime":843.535,"endTime":846.535,"body":"would people do that? Why would"},{"speaker":"Bruce Leuchter","startTime":843.535,"endTime":846.535,"body":"people take on that binary risk?"},{"speaker":"Bruce Leuchter","startTime":846.535,"endTime":851.155,"body":"And the answer isn't, in my"},{"speaker":"Bruce Leuchter","startTime":846.535,"endTime":851.155,"body":"mind, because there's economic"},{"speaker":"Bruce Leuchter","startTime":851.155,"endTime":856.6,"body":"upside if you succeed. The"},{"speaker":"Bruce Leuchter","startTime":851.155,"endTime":856.6,"body":"answer is that in so doing, in"},{"speaker":"Bruce Leuchter","startTime":856.6,"endTime":859.48,"body":"all of the blocking and"},{"speaker":"Bruce Leuchter","startTime":856.6,"endTime":859.48,"body":"tackling, the sausage making,"},{"speaker":"Bruce Leuchter","startTime":860.02,"endTime":864.7,"body":"you are coalescing as a really"},{"speaker":"Bruce Leuchter","startTime":860.02,"endTime":864.7,"body":"sharp, capable, intelligent"},{"speaker":"Bruce Leuchter","startTime":864.7,"endTime":870.94,"body":"group of people, and the sum is"},{"speaker":"Bruce Leuchter","startTime":864.7,"endTime":870.94,"body":"greater than the parts, and it's"},{"speaker":"Bruce Leuchter","startTime":870.94,"endTime":874.96,"body":"a living, breathing creature."},{"speaker":"Bruce Leuchter","startTime":870.94,"endTime":874.96,"body":"You have to want a lot of"},{"speaker":"Bruce Leuchter","startTime":875.32,"endTime":878.605,"body":"activity and fire drills and"},{"speaker":"Bruce Leuchter","startTime":875.32,"endTime":878.605,"body":"things that need to get solved"},{"speaker":"Bruce Leuchter","startTime":878.605,"endTime":881.545,"body":"for on a daily basis in order to"},{"speaker":"Bruce Leuchter","startTime":878.605,"endTime":881.545,"body":"like this job. But if you want"},{"speaker":"Bruce Leuchter","startTime":881.545,"endTime":885.145,"body":"it, you will love the job,"},{"speaker":"Bruce Leuchter","startTime":881.545,"endTime":885.145,"body":"because there's all of that and"},{"speaker":"Bruce Leuchter","startTime":885.145,"endTime":889.705,"body":"then some. And if you succeed,"},{"speaker":"Bruce Leuchter","startTime":885.145,"endTime":889.705,"body":"you've succeeded because you've"},{"speaker":"Bruce Leuchter","startTime":889.705,"endTime":893.665,"body":"gotten folks to believe that the"},{"speaker":"Bruce Leuchter","startTime":889.705,"endTime":893.665,"body":"team that's being brought to"},{"speaker":"Bruce Leuchter","startTime":893.665,"endTime":898.285,"body":"bear on this particular project"},{"speaker":"Bruce Leuchter","startTime":893.665,"endTime":898.285,"body":"is a team that can't be beat."},{"speaker":"Bruce Leuchter","startTime":898.63,"endTime":901.81,"body":"And it's not so much being"},{"speaker":"Bruce Leuchter","startTime":898.63,"endTime":901.81,"body":"beaten by other people or other"},{"speaker":"Bruce Leuchter","startTime":901.81,"endTime":907.27,"body":"companies. It's about winning in"},{"speaker":"Bruce Leuchter","startTime":901.81,"endTime":907.27,"body":"coalescing as a group and"},{"speaker":"Bruce Leuchter","startTime":907.27,"endTime":910.87,"body":"delivering results that"},{"speaker":"Bruce Leuchter","startTime":907.27,"endTime":910.87,"body":"inevitably benefit the"},{"speaker":"Bruce Leuchter","startTime":910.87,"endTime":913.21,"body":"communities you're trying to"},{"speaker":"Bruce Leuchter","startTime":910.87,"endTime":913.21,"body":"treat. In the event that you do"},{"speaker":"Bruce Leuchter","startTime":913.21,"endTime":917.47,"body":"not succeed in getting a drug"},{"speaker":"Bruce Leuchter","startTime":913.21,"endTime":917.47,"body":"approved, you have certainly"},{"speaker":"Bruce Leuchter","startTime":917.47,"endTime":921.43,"body":"succeeded in giving hope to"},{"speaker":"Bruce Leuchter","startTime":917.47,"endTime":921.43,"body":"patients who've participated in"},{"speaker":"Bruce Leuchter","startTime":921.43,"endTime":924.655,"body":"the study, patient advocacy"},{"speaker":"Bruce Leuchter","startTime":921.43,"endTime":924.655,"body":"organizations who haven't had as"},{"speaker":"Bruce Leuchter","startTime":924.655,"endTime":927.295,"body":"much visibility prior to your"},{"speaker":"Bruce Leuchter","startTime":924.655,"endTime":927.295,"body":"engagement around their disease,"},{"speaker":"Bruce Leuchter","startTime":927.355,"endTime":929.755,"body":"the relationships that you've"},{"speaker":"Bruce Leuchter","startTime":927.355,"endTime":929.755,"body":"built, the education that you've"},{"speaker":"Bruce Leuchter","startTime":929.755,"endTime":934.555,"body":"provided to all stakeholders."},{"speaker":"Bruce Leuchter","startTime":929.755,"endTime":934.555,"body":"It's beneficial net, net, to be"},{"speaker":"Bruce Leuchter","startTime":934.555,"endTime":939.235,"body":"sure, and I think you've got to"},{"speaker":"Bruce Leuchter","startTime":934.555,"endTime":939.235,"body":"want that to embrace this, you"},{"speaker":"Bruce Leuchter","startTime":939.235,"endTime":943.495,"body":"know this, binary risk that"},{"speaker":"Bruce Leuchter","startTime":939.235,"endTime":943.495,"body":"floats above all of our heads."},{"speaker":"John Simboli","startTime":945.1,"endTime":949.3,"body":"When I first"},{"speaker":"John Simboli","startTime":945.1,"endTime":949.3,"body":"started doing the podcast, I was"},{"speaker":"John Simboli","startTime":949.36,"endTime":954.16,"body":"physically going to executives"},{"speaker":"John Simboli","startTime":949.36,"endTime":954.16,"body":"offices and bringing my kit and"},{"speaker":"John Simboli","startTime":954.16,"endTime":958.42,"body":"doing this, and then during the"},{"speaker":"John Simboli","startTime":954.16,"endTime":958.42,"body":"the, you know, the pandemic, of"},{"speaker":"John Simboli","startTime":958.42,"endTime":961.24,"body":"course, I found this format that"},{"speaker":"John Simboli","startTime":958.42,"endTime":961.24,"body":"we're working in today worked."},{"speaker":"John Simboli","startTime":961.24,"endTime":964.66,"body":"And one of the things I found"},{"speaker":"John Simboli","startTime":961.24,"endTime":964.66,"body":"through that discussion was I'd"},{"speaker":"John Simboli","startTime":964.66,"endTime":968.245,"body":"be talking, you know, across a"},{"speaker":"John Simboli","startTime":964.66,"endTime":968.245,"body":"kitchen table, you know, 11"},{"speaker":"John Simboli","startTime":968.245,"endTime":972.205,"body":"o'clock at night with someone"},{"speaker":"John Simboli","startTime":968.245,"endTime":972.205,"body":"and and they, the family, would"},{"speaker":"John Simboli","startTime":972.205,"endTime":974.425,"body":"pass through the frame, someone"},{"speaker":"John Simboli","startTime":972.205,"endTime":974.425,"body":"from the family passed through."},{"speaker":"John Simboli","startTime":974.425,"endTime":978.625,"body":"And it led to this discussion"},{"speaker":"John Simboli","startTime":974.425,"endTime":978.625,"body":"about what it is that a CEO does"},{"speaker":"John Simboli","startTime":978.625,"endTime":981.565,"body":"at a biopharma company. So"},{"speaker":"John Simboli","startTime":978.625,"endTime":981.565,"body":"here's what I'm trying to get"},{"speaker":"John Simboli","startTime":981.565,"endTime":985.105,"body":"at, an executive at a big pharma"},{"speaker":"John Simboli","startTime":981.565,"endTime":985.105,"body":"company, people probably have a"},{"speaker":"John Simboli","startTime":985.105,"endTime":988.825,"body":"certain idea of what that job is"},{"speaker":"John Simboli","startTime":985.105,"endTime":988.825,"body":"like. It's probably very much a"},{"speaker":"John Simboli","startTime":988.825,"endTime":992.59,"body":"managerial job, because it's a"},{"speaker":"John Simboli","startTime":988.825,"endTime":992.59,"body":"big thing. And then people"},{"speaker":"John Simboli","startTime":992.65,"endTime":996.25,"body":"probably have a rudimentary idea"},{"speaker":"John Simboli","startTime":992.65,"endTime":996.25,"body":"what a scientist does. And they"},{"speaker":"John Simboli","startTime":996.25,"endTime":1001.53,"body":"picture being in the lab. What"},{"speaker":"John Simboli","startTime":996.25,"endTime":1001.53,"body":"is your day like? When someone"},{"speaker":"John Simboli","startTime":1001.53,"endTime":1003.87,"body":"says to you, what do you do for"},{"speaker":"John Simboli","startTime":1001.53,"endTime":1003.87,"body":"a living? How do you try to"},{"speaker":"John Simboli","startTime":1003.87,"endTime":1006.03,"body":"explain that? How does your day"},{"speaker":"John Simboli","startTime":1003.87,"endTime":1006.03,"body":"go by?"},{"speaker":"Bruce Leuchter","startTime":1006.9,"endTime":1008.76,"body":"Well, the"},{"speaker":"Bruce Leuchter","startTime":1006.9,"endTime":1008.76,"body":"easiest answer, and I get that"},{"speaker":"Bruce Leuchter","startTime":1008.76,"endTime":1013.14,"body":"question all the time, is I try"},{"speaker":"Bruce Leuchter","startTime":1008.76,"endTime":1013.14,"body":"to develop novel therapies for"},{"speaker":"Bruce Leuchter","startTime":1013.14,"endTime":1015.36,"body":"diseases of the brain and"},{"speaker":"Bruce Leuchter","startTime":1013.14,"endTime":1015.36,"body":"nervous system. I think most"},{"speaker":"Bruce Leuchter","startTime":1015.36,"endTime":1018.78,"body":"people can get that. What they"},{"speaker":"Bruce Leuchter","startTime":1015.36,"endTime":1018.78,"body":"don't necessarily get is how you"},{"speaker":"Bruce Leuchter","startTime":1018.78,"endTime":1023.58,"body":"do it on a day to day basis. And"},{"speaker":"Bruce Leuchter","startTime":1018.78,"endTime":1023.58,"body":"the diversification of"},{"speaker":"Bruce Leuchter","startTime":1023.58,"endTime":1029.64,"body":"experiences that I am able to"},{"speaker":"Bruce Leuchter","startTime":1023.58,"endTime":1029.64,"body":"have, need to have on a daily"},{"speaker":"Bruce Leuchter","startTime":1029.64,"endTime":1033.045,"body":"basis, is just what the doctor"},{"speaker":"Bruce Leuchter","startTime":1029.64,"endTime":1033.045,"body":"ordered. So at any given moment"},{"speaker":"Bruce Leuchter","startTime":1033.045,"endTime":1038.925,"body":"in time, I may be knee deep in"},{"speaker":"Bruce Leuchter","startTime":1033.045,"endTime":1038.925,"body":"an HR related issue, and there"},{"speaker":"Bruce Leuchter","startTime":1038.925,"endTime":1042.825,"body":"are all sorts of considerations"},{"speaker":"Bruce Leuchter","startTime":1038.925,"endTime":1042.825,"body":"that one needs to bring to bear,"},{"speaker":"Bruce Leuchter","startTime":1042.885,"endTime":1045.645,"body":"most of which require some level"},{"speaker":"Bruce Leuchter","startTime":1042.885,"endTime":1045.645,"body":"of mindfulness and self"},{"speaker":"Bruce Leuchter","startTime":1045.645,"endTime":1049.545,"body":"awareness and solution oriented"},{"speaker":"Bruce Leuchter","startTime":1045.645,"endTime":1049.545,"body":"thinking, and that has nothing"},{"speaker":"Bruce Leuchter","startTime":1049.545,"endTime":1052.425,"body":"to do with developing drugs, per"},{"speaker":"Bruce Leuchter","startTime":1049.545,"endTime":1052.425,"body":"se, it's about developing people"},{"speaker":"Bruce Leuchter","startTime":1052.425,"endTime":1056.49,"body":"and managing people, which, as I"},{"speaker":"Bruce Leuchter","startTime":1052.425,"endTime":1056.49,"body":"mentioned in my last comment, is"},{"speaker":"Bruce Leuchter","startTime":1056.49,"endTime":1059.43,"body":"critical to the success of a"},{"speaker":"Bruce Leuchter","startTime":1056.49,"endTime":1059.43,"body":"biotech company. In the next"},{"speaker":"Bruce Leuchter","startTime":1059.43,"endTime":1063.99,"body":"hour after that heavy duty HR"},{"speaker":"Bruce Leuchter","startTime":1059.43,"endTime":1063.99,"body":"meeting, I may find my way into"},{"speaker":"Bruce Leuchter","startTime":1063.99,"endTime":1066.99,"body":"a clinical development meeting"},{"speaker":"Bruce Leuchter","startTime":1063.99,"endTime":1066.99,"body":"talking about clinical trial"},{"speaker":"Bruce Leuchter","startTime":1066.99,"endTime":1073.23,"body":"design, and now I get to put on"},{"speaker":"Bruce Leuchter","startTime":1066.99,"endTime":1073.23,"body":"my neuroscience cap and think"},{"speaker":"Bruce Leuchter","startTime":1073.23,"endTime":1076.335,"body":"about biology. Think about"},{"speaker":"Bruce Leuchter","startTime":1073.23,"endTime":1076.335,"body":"disease states, think about"},{"speaker":"Bruce Leuchter","startTime":1076.335,"endTime":1081.555,"body":"physician behavior. It's"},{"speaker":"Bruce Leuchter","startTime":1076.335,"endTime":1081.555,"body":"gratifying, it's intricate, and"},{"speaker":"Bruce Leuchter","startTime":1082.695,"endTime":1087.615,"body":"it's a big part of what I do. In"},{"speaker":"Bruce Leuchter","startTime":1082.695,"endTime":1087.615,"body":"the hour following that meeting,"},{"speaker":"Bruce Leuchter","startTime":1087.735,"endTime":1092.235,"body":"I may find myself talking to"},{"speaker":"Bruce Leuchter","startTime":1087.735,"endTime":1092.235,"body":"investors who may have macro"},{"speaker":"Bruce Leuchter","startTime":1092.235,"endTime":1097.455,"body":"concerns about the market or the"},{"speaker":"Bruce Leuchter","startTime":1092.235,"endTime":1097.455,"body":"broader neuroscience space, and"},{"speaker":"Bruce Leuchter","startTime":1097.455,"endTime":1100.86,"body":"wonder how our business is"},{"speaker":"Bruce Leuchter","startTime":1097.455,"endTime":1100.86,"body":"accounting for those macro"},{"speaker":"Bruce Leuchter","startTime":1100.86,"endTime":1103.38,"body":"developments. They may be just"},{"speaker":"Bruce Leuchter","startTime":1100.86,"endTime":1103.38,"body":"as much in the weeds on the"},{"speaker":"Bruce Leuchter","startTime":1103.38,"endTime":1108.54,"body":"micro topics, at which point I'm"},{"speaker":"Bruce Leuchter","startTime":1103.38,"endTime":1108.54,"body":"talking about the science that"},{"speaker":"Bruce Leuchter","startTime":1108.54,"endTime":1110.7,"body":"we're progressing and the"},{"speaker":"Bruce Leuchter","startTime":1108.54,"endTime":1110.7,"body":"clinical work that we're doing"},{"speaker":"Bruce Leuchter","startTime":1111.24,"endTime":1115.62,"body":"in a way that is well received"},{"speaker":"Bruce Leuchter","startTime":1111.24,"endTime":1115.62,"body":"or can be well received by an"},{"speaker":"Bruce Leuchter","startTime":1115.62,"endTime":1118.8,"body":"investor who's thinking about"},{"speaker":"Bruce Leuchter","startTime":1115.62,"endTime":1118.8,"body":"deploying capital into an"},{"speaker":"Bruce Leuchter","startTime":1118.8,"endTime":1123.285,"body":"investment. In the hour after"},{"speaker":"Bruce Leuchter","startTime":1118.8,"endTime":1123.285,"body":"that, I could find myself on the"},{"speaker":"Bruce Leuchter","startTime":1123.285,"endTime":1127.605,"body":"line with investment bankers who"},{"speaker":"Bruce Leuchter","startTime":1123.285,"endTime":1127.605,"body":"are wondering whether the IPO"},{"speaker":"Bruce Leuchter","startTime":1127.605,"endTime":1133.245,"body":"markets will reconstitute, and"},{"speaker":"Bruce Leuchter","startTime":1127.605,"endTime":1133.245,"body":"are thinking about the fate of"},{"speaker":"Bruce Leuchter","startTime":1133.305,"endTime":1136.065,"body":"emerging growth biotech"},{"speaker":"Bruce Leuchter","startTime":1133.305,"endTime":1136.065,"body":"companies in the world we"},{"speaker":"Bruce Leuchter","startTime":1136.065,"endTime":1140.025,"body":"currently live in, and all the"},{"speaker":"Bruce Leuchter","startTime":1136.065,"endTime":1140.025,"body":"different three dimensional"},{"speaker":"Bruce Leuchter","startTime":1140.025,"endTime":1142.905,"body":"chess that one needs to play"},{"speaker":"Bruce Leuchter","startTime":1140.025,"endTime":1142.905,"body":"around that as we try to fund"},{"speaker":"Bruce Leuchter","startTime":1143.085,"endTime":1145.125,"body":"the companies that could"},{"speaker":"Bruce Leuchter","startTime":1143.085,"endTime":1145.125,"body":"potentially deliver these"},{"speaker":"Bruce Leuchter","startTime":1145.125,"endTime":1149.19,"body":"treatments to patients, it's the"},{"speaker":"Bruce Leuchter","startTime":1145.125,"endTime":1149.19,"body":"richest of experiences. And for"},{"speaker":"Bruce Leuchter","startTime":1149.25,"endTime":1154.59,"body":"people who do like to bob and"},{"speaker":"Bruce Leuchter","startTime":1149.25,"endTime":1154.59,"body":"weave, which is the terminology"},{"speaker":"Bruce Leuchter","startTime":1154.59,"endTime":1158.49,"body":"I tend to use, there's plenty of"},{"speaker":"Bruce Leuchter","startTime":1154.59,"endTime":1158.49,"body":"it in this role. I think it"},{"speaker":"Bruce Leuchter","startTime":1158.49,"endTime":1162.93,"body":"keeps you sharp. I think you"},{"speaker":"Bruce Leuchter","startTime":1158.49,"endTime":1162.93,"body":"have to care not just about any"},{"speaker":"Bruce Leuchter","startTime":1162.99,"endTime":1166.29,"body":"particular function, but about"},{"speaker":"Bruce Leuchter","startTime":1162.99,"endTime":1166.29,"body":"the broader organization. And"},{"speaker":"Bruce Leuchter","startTime":1166.71,"endTime":1169.395,"body":"you've got to care about your"},{"speaker":"Bruce Leuchter","startTime":1166.71,"endTime":1169.395,"body":"stakeholders. Because as much as"},{"speaker":"Bruce Leuchter","startTime":1169.395,"endTime":1174.915,"body":"you're managing a team of highly"},{"speaker":"Bruce Leuchter","startTime":1169.395,"endTime":1174.915,"body":"capable, gifted people on the"},{"speaker":"Bruce Leuchter","startTime":1174.915,"endTime":1178.335,"body":"operating side, you're managing"},{"speaker":"Bruce Leuchter","startTime":1174.915,"endTime":1178.335,"body":"a team of highly capable, often"},{"speaker":"Bruce Leuchter","startTime":1178.335,"endTime":1181.935,"body":"highly successful people on the"},{"speaker":"Bruce Leuchter","startTime":1178.335,"endTime":1181.935,"body":"board front, and there's a lot"},{"speaker":"Bruce Leuchter","startTime":1181.935,"endTime":1183.975,"body":"of considerations that surround"},{"speaker":"Bruce Leuchter","startTime":1181.935,"endTime":1183.975,"body":"that too. We are in the"},{"speaker":"Bruce Leuchter","startTime":1183.975,"endTime":1188.475,"body":"fortunate position at Neurvati"},{"speaker":"Bruce Leuchter","startTime":1183.975,"endTime":1188.475,"body":"GRIN of having just a tremendous"},{"speaker":"Bruce Leuchter","startTime":1188.475,"endTime":1192.435,"body":"board of directors with people"},{"speaker":"Bruce Leuchter","startTime":1188.475,"endTime":1192.435,"body":"whose experiences range across"},{"speaker":"Bruce Leuchter","startTime":1192.48,"endTime":1195.36,"body":"the industry in all sorts of"},{"speaker":"Bruce Leuchter","startTime":1192.48,"endTime":1195.36,"body":"senior leadership roles, and we"},{"speaker":"Bruce Leuchter","startTime":1195.36,"endTime":1198.18,"body":"benefit from that mind share on"},{"speaker":"Bruce Leuchter","startTime":1195.36,"endTime":1198.18,"body":"a daily basis. But that too"},{"speaker":"Bruce Leuchter","startTime":1198.18,"endTime":1202.44,"body":"requires management So people"},{"speaker":"Bruce Leuchter","startTime":1198.18,"endTime":1202.44,"body":"often say that the CEO role is a"},{"speaker":"Bruce Leuchter","startTime":1202.44,"endTime":1205.02,"body":"lonely role. If I've heard that"},{"speaker":"Bruce Leuchter","startTime":1202.44,"endTime":1205.02,"body":"from one person,  I've heard it"},{"speaker":"Bruce Leuchter","startTime":1205.02,"endTime":1208.26,"body":"from 1000. And to some extent"},{"speaker":"Bruce Leuchter","startTime":1205.02,"endTime":1208.26,"body":"they're right about that."},{"speaker":"Bruce Leuchter","startTime":1208.26,"endTime":1211.62,"body":"There's one person in charge of"},{"speaker":"Bruce Leuchter","startTime":1208.26,"endTime":1211.62,"body":"what I'm in charge of. But I"},{"speaker":"Bruce Leuchter","startTime":1211.62,"endTime":1215.565,"body":"don't see it as an N-of-1"},{"speaker":"Bruce Leuchter","startTime":1211.62,"endTime":1215.565,"body":"exercise, where one might think"},{"speaker":"Bruce Leuchter","startTime":1215.565,"endTime":1220.305,"body":"about loneliness existing in an"},{"speaker":"Bruce Leuchter","startTime":1215.565,"endTime":1220.305,"body":"N-of-1 world. I see it as an N"},{"speaker":"Bruce Leuchter","startTime":1220.305,"endTime":1224.145,"body":"of infinity world, because in"},{"speaker":"Bruce Leuchter","startTime":1220.305,"endTime":1224.145,"body":"any given moment, whether it's"},{"speaker":"Bruce Leuchter","startTime":1224.145,"endTime":1226.725,"body":"an employee, whether it's the"},{"speaker":"Bruce Leuchter","startTime":1224.145,"endTime":1226.725,"body":"executive leadership team, it's"},{"speaker":"Bruce Leuchter","startTime":1226.725,"endTime":1229.665,"body":"a vendor, aan investor, a"},{"speaker":"Bruce Leuchter","startTime":1226.725,"endTime":1229.665,"body":"banker, a consultant, a"},{"speaker":"Bruce Leuchter","startTime":1229.665,"endTime":1232.965,"body":"stakeholder at the board level,"},{"speaker":"Bruce Leuchter","startTime":1229.665,"endTime":1232.965,"body":"there's constant dialog,"},{"speaker":"Bruce Leuchter","startTime":1232.965,"endTime":1236.925,"body":"constant thought experiments and"},{"speaker":"Bruce Leuchter","startTime":1232.965,"endTime":1236.925,"body":"constant solution oriented"},{"speaker":"Bruce Leuchter","startTime":1236.925,"endTime":1239.55,"body":"thinking. And that doesn't make"},{"speaker":"Bruce Leuchter","startTime":1236.925,"endTime":1239.55,"body":"me feel lonely at all. You have"},{"speaker":"Bruce Leuchter","startTime":1239.55,"endTime":1243.45,"body":"to want to go out and get it and"},{"speaker":"Bruce Leuchter","startTime":1239.55,"endTime":1243.45,"body":"not believe that you don't need"},{"speaker":"Bruce Leuchter","startTime":1243.45,"endTime":1246.87,"body":"it. I think if there's one thing"},{"speaker":"Bruce Leuchter","startTime":1243.45,"endTime":1246.87,"body":"that everyone should learn about"},{"speaker":"Bruce Leuchter","startTime":1246.87,"endTime":1250.83,"body":"this role is that more"},{"speaker":"Bruce Leuchter","startTime":1246.87,"endTime":1250.83,"body":"perspective, more information,"},{"speaker":"Bruce Leuchter","startTime":1250.89,"endTime":1254.43,"body":"you know, more mind expansion"},{"speaker":"Bruce Leuchter","startTime":1250.89,"endTime":1254.43,"body":"equals higher probability of"},{"speaker":"Bruce Leuchter","startTime":1254.43,"endTime":1258.39,"body":"success, and you want to take as"},{"speaker":"Bruce Leuchter","startTime":1254.43,"endTime":1258.39,"body":"much of that on as you possibly"},{"speaker":"Bruce Leuchter","startTime":1258.39,"endTime":1262.575,"body":"can. It requires a healthy ego"},{"speaker":"Bruce Leuchter","startTime":1258.39,"endTime":1262.575,"body":"to do it, but it is definitely"},{"speaker":"Bruce Leuchter","startTime":1262.575,"endTime":1266.715,"body":"beneficial, so I don't"},{"speaker":"Bruce Leuchter","startTime":1262.575,"endTime":1266.715,"body":"experience the sort of classic"},{"speaker":"Bruce Leuchter","startTime":1266.775,"endTime":1269.655,"body":"loneliness that folks talk"},{"speaker":"Bruce Leuchter","startTime":1266.775,"endTime":1269.655,"body":"about. That doesn't mean the job"},{"speaker":"Bruce Leuchter","startTime":1270.255,"endTime":1272.355,"body":"isn't challenging,"},{"speaker":"Bruce Leuchter","startTime":1270.255,"endTime":1272.355,"body":"psychologically. Of course, it"},{"speaker":"Bruce Leuchter","startTime":1272.355,"endTime":1274.935,"body":"is when you're thinking about"},{"speaker":"Bruce Leuchter","startTime":1272.355,"endTime":1274.935,"body":"all the different roles and"},{"speaker":"Bruce Leuchter","startTime":1274.935,"endTime":1278.475,"body":"responsibilities that the CEO"},{"speaker":"Bruce Leuchter","startTime":1274.935,"endTime":1278.475,"body":"plays. But I'm in the fortunate"},{"speaker":"Bruce Leuchter","startTime":1278.475,"endTime":1281.715,"body":"position of working with the"},{"speaker":"Bruce Leuchter","startTime":1278.475,"endTime":1281.715,"body":"best people in the industry, no"},{"speaker":"Bruce Leuchter","startTime":1281.715,"endTime":1284.76,"body":"matter who we're talking about,"},{"speaker":"Bruce Leuchter","startTime":1281.715,"endTime":1284.76,"body":"stakeholders, or the executive"},{"speaker":"Bruce Leuchter","startTime":1284.76,"endTime":1288.06,"body":"leadership team, or or any given"},{"speaker":"Bruce Leuchter","startTime":1284.76,"endTime":1288.06,"body":"person in the company. And for"},{"speaker":"Bruce Leuchter","startTime":1288.06,"endTime":1288.96,"body":"me, that's a big win."},{"speaker":"John Simboli","startTime":1289.92,"endTime":1293.82,"body":"Your phrase \"bob"},{"speaker":"John Simboli","startTime":1289.92,"endTime":1293.82,"body":"and weave\" catches my ear, and I"},{"speaker":"John Simboli","startTime":1293.82,"endTime":1296.46,"body":"don't want to strain the"},{"speaker":"John Simboli","startTime":1293.82,"endTime":1296.46,"body":"metaphor, but it certainly"},{"speaker":"John Simboli","startTime":1296.46,"endTime":1300.48,"body":"brings to mind the image of a"},{"speaker":"John Simboli","startTime":1296.46,"endTime":1300.48,"body":"boxer and someone who knows how,"},{"speaker":"John Simboli","startTime":1300.48,"endTime":1303.78,"body":"through their footwork, to"},{"speaker":"John Simboli","startTime":1300.48,"endTime":1303.78,"body":"approach the moment and when to"},{"speaker":"John Simboli","startTime":1303.78,"endTime":1309.225,"body":"back off. So to follow that"},{"speaker":"John Simboli","startTime":1303.78,"endTime":1309.225,"body":"analogy, when you close, when"},{"speaker":"John Simboli","startTime":1309.225,"endTime":1314.145,"body":"you come in and really engage on"},{"speaker":"John Simboli","startTime":1309.225,"endTime":1314.145,"body":"something, how do you know when"},{"speaker":"John Simboli","startTime":1314.145,"endTime":1317.925,"body":"to do that and make whatever"},{"speaker":"John Simboli","startTime":1314.145,"endTime":1317.925,"body":"decision you have to make as a"},{"speaker":"John Simboli","startTime":1317.925,"endTime":1325.845,"body":"CEO, versus when to disengage,"},{"speaker":"John Simboli","startTime":1317.925,"endTime":1325.845,"body":"go back to what you just spoke"},{"speaker":"John Simboli","startTime":1325.845,"endTime":1328.318,"body":"about, bringing in all the"},{"speaker":"John Simboli","startTime":1325.845,"endTime":1328.318,"body":"information and try to evaluate"},{"speaker":"John Simboli","startTime":1328.318,"endTime":1328.35,"body":"it. I imagine it's a never"},{"speaker":"John Simboli","startTime":1328.318,"endTime":1328.35,"body":"ending, in and out, back and"},{"speaker":"John Simboli","startTime":1328.35,"endTime":1330.63,"body":"forth. But how does one do that?"},{"speaker":"Bruce Leuchter","startTime":1330.24,"endTime":1336.6,"body":"Well, I think no"},{"speaker":"Bruce Leuchter","startTime":1330.24,"endTime":1336.6,"body":"one should believe that there is"},{"speaker":"Bruce Leuchter","startTime":1336.6,"endTime":1341.88,"body":"ever a perfect decision. And I"},{"speaker":"Bruce Leuchter","startTime":1336.6,"endTime":1341.88,"body":"think if you convinced yourself"},{"speaker":"Bruce Leuchter","startTime":1341.88,"endTime":1346.14,"body":"of that and you're out trying to"},{"speaker":"Bruce Leuchter","startTime":1341.88,"endTime":1346.14,"body":"find it, it may amount to a bit"},{"speaker":"Bruce Leuchter","startTime":1346.14,"endTime":1350.22,"body":"of a wild goose chase. And the"},{"speaker":"Bruce Leuchter","startTime":1346.14,"endTime":1350.22,"body":"bobbing and weaving isn't so"},{"speaker":"Bruce Leuchter","startTime":1350.22,"endTime":1354.885,"body":"much evasion of different"},{"speaker":"Bruce Leuchter","startTime":1350.22,"endTime":1354.885,"body":"opinions, personalities,"},{"speaker":"Bruce Leuchter","startTime":1354.885,"endTime":1358.725,"body":"decisions, etc. It's more"},{"speaker":"Bruce Leuchter","startTime":1354.885,"endTime":1358.725,"body":"nimbleness, you know, light on"},{"speaker":"Bruce Leuchter","startTime":1358.725,"endTime":1363.465,"body":"your feet, figuring out how to"},{"speaker":"Bruce Leuchter","startTime":1358.725,"endTime":1363.465,"body":"move and change with the daily"},{"speaker":"Bruce Leuchter","startTime":1363.525,"endTime":1368.865,"body":"changing environment in which we"},{"speaker":"Bruce Leuchter","startTime":1363.525,"endTime":1368.865,"body":"live as biotech folks. And"},{"speaker":"Bruce Leuchter","startTime":1369.465,"endTime":1372.225,"body":"because there is no perfect"},{"speaker":"Bruce Leuchter","startTime":1369.465,"endTime":1372.225,"body":"decision, it's about"},{"speaker":"Bruce Leuchter","startTime":1372.645,"endTime":1376.665,"body":"triangulating around the best"},{"speaker":"Bruce Leuchter","startTime":1372.645,"endTime":1376.665,"body":"decision. And if you allow"},{"speaker":"Bruce Leuchter","startTime":1376.665,"endTime":1380.13,"body":"perfect to be the enemy of the"},{"speaker":"Bruce Leuchter","startTime":1376.665,"endTime":1380.13,"body":"good, you may never find that"},{"speaker":"Bruce Leuchter","startTime":1380.13,"endTime":1383.55,"body":"decisive moment. You may always"},{"speaker":"Bruce Leuchter","startTime":1380.13,"endTime":1383.55,"body":"be sitting there ambivalating"},{"speaker":"Bruce Leuchter","startTime":1383.67,"endTime":1387.51,"body":"about what it is that's best for"},{"speaker":"Bruce Leuchter","startTime":1383.67,"endTime":1387.51,"body":"the company. But if you take on"},{"speaker":"Bruce Leuchter","startTime":1387.57,"endTime":1389.79,"body":"these different vantage points"},{"speaker":"Bruce Leuchter","startTime":1387.57,"endTime":1389.79,"body":"and you appropriately"},{"speaker":"Bruce Leuchter","startTime":1389.79,"endTime":1394.05,"body":"contextualize them based on the"},{"speaker":"Bruce Leuchter","startTime":1389.79,"endTime":1394.05,"body":"source from which it's coming, I"},{"speaker":"Bruce Leuchter","startTime":1394.05,"endTime":1399.795,"body":"think it gives you enough"},{"speaker":"Bruce Leuchter","startTime":1394.05,"endTime":1399.795,"body":"information to ultimately come"},{"speaker":"Bruce Leuchter","startTime":1399.795,"endTime":1403.815,"body":"to a conclusion that is best for"},{"speaker":"Bruce Leuchter","startTime":1399.795,"endTime":1403.815,"body":"the company, that you believe"},{"speaker":"Bruce Leuchter","startTime":1403.815,"endTime":1407.295,"body":"wholeheartedly is going to yield"},{"speaker":"Bruce Leuchter","startTime":1403.815,"endTime":1407.295,"body":"the most amount of success, and"},{"speaker":"Bruce Leuchter","startTime":1407.295,"endTime":1410.295,"body":"recognize that there are going"},{"speaker":"Bruce Leuchter","startTime":1407.295,"endTime":1410.295,"body":"to be challenges associated with"},{"speaker":"Bruce Leuchter","startTime":1410.295,"endTime":1412.935,"body":"that decision more often than"},{"speaker":"Bruce Leuchter","startTime":1410.295,"endTime":1412.935,"body":"there isn't. And as long as"},{"speaker":"Bruce Leuchter","startTime":1412.935,"endTime":1415.815,"body":"you're prepared to contend with"},{"speaker":"Bruce Leuchter","startTime":1412.935,"endTime":1415.815,"body":"that, you can remain light on"},{"speaker":"Bruce Leuchter","startTime":1415.815,"endTime":1418.755,"body":"your feet. You can continue to"},{"speaker":"Bruce Leuchter","startTime":1415.815,"endTime":1418.755,"body":"bob and weave. It's probably"},{"speaker":"Bruce Leuchter","startTime":1418.755,"endTime":1422.895,"body":"important to think about bob and"},{"speaker":"Bruce Leuchter","startTime":1418.755,"endTime":1422.895,"body":"weave in the way that I do,"},{"speaker":"Bruce Leuchter","startTime":1422.895,"endTime":1427.08,"body":"which isn't so much trying to"},{"speaker":"Bruce Leuchter","startTime":1422.895,"endTime":1427.08,"body":"sidestep problems, you know,"},{"speaker":"Bruce Leuchter","startTime":1427.08,"endTime":1430.5,"body":"trying to bounce around and"},{"speaker":"Bruce Leuchter","startTime":1427.08,"endTime":1430.5,"body":"evade a punch. It's more about"},{"speaker":"Bruce Leuchter","startTime":1430.5,"endTime":1432.9,"body":"trying to get the rhythm of the"},{"speaker":"Bruce Leuchter","startTime":1430.5,"endTime":1432.9,"body":"business, trying to get, trying"},{"speaker":"Bruce Leuchter","startTime":1432.9,"endTime":1436.44,"body":"to understand the people that"},{"speaker":"Bruce Leuchter","startTime":1432.9,"endTime":1436.44,"body":"you're working across from or"},{"speaker":"Bruce Leuchter","startTime":1436.44,"endTime":1441.06,"body":"next to, and incorporate their"},{"speaker":"Bruce Leuchter","startTime":1436.44,"endTime":1441.06,"body":"style into what it is that you"},{"speaker":"Bruce Leuchter","startTime":1441.06,"endTime":1445.485,"body":"need to accomplish. Because it"},{"speaker":"Bruce Leuchter","startTime":1441.06,"endTime":1445.485,"body":"is not monolithic. It is not an"},{"speaker":"Bruce Leuchter","startTime":1445.485,"endTime":1451.005,"body":"N equals 1 role, and it is one"},{"speaker":"Bruce Leuchter","startTime":1445.485,"endTime":1451.005,"body":"that requires onboarding the"},{"speaker":"Bruce Leuchter","startTime":1451.005,"endTime":1455.625,"body":"kinds of perspectives that you"},{"speaker":"Bruce Leuchter","startTime":1451.005,"endTime":1455.625,"body":"perhaps don't have but need to"},{"speaker":"Bruce Leuchter","startTime":1455.625,"endTime":1458.445,"body":"quickly understand to get to the"},{"speaker":"Bruce Leuchter","startTime":1455.625,"endTime":1458.445,"body":"right decision."},{"speaker":"John Simboli","startTime":1459.105,"endTime":1462.405,"body":"When you were a"},{"speaker":"John Simboli","startTime":1459.105,"endTime":1462.405,"body":"kid, can you picture thinking"},{"speaker":"John Simboli","startTime":1462.825,"endTime":1466.125,"body":"I'd like to be this when I grow"},{"speaker":"John Simboli","startTime":1462.825,"endTime":1466.125,"body":"up? Did the this turn out to be"},{"speaker":"John Simboli","startTime":1466.125,"endTime":1468.945,"body":"that? What you're doing? Or is"},{"speaker":"John Simboli","startTime":1466.125,"endTime":1468.945,"body":"this something else?"},{"speaker":"Bruce Leuchter","startTime":1469.14,"endTime":1472.8,"body":"I didn't for a"},{"speaker":"Bruce Leuchter","startTime":1469.14,"endTime":1472.8,"body":"moment see myself pursuing the"},{"speaker":"Bruce Leuchter","startTime":1472.92,"endTime":1475.92,"body":"things that I've pursued,"},{"speaker":"Bruce Leuchter","startTime":1472.92,"endTime":1475.92,"body":"certainly not being the CEO of a"},{"speaker":"Bruce Leuchter","startTime":1475.92,"endTime":1482.7,"body":"biotech company. What I did see"},{"speaker":"Bruce Leuchter","startTime":1475.92,"endTime":1482.7,"body":"was a lot of neurology. And, you"},{"speaker":"Bruce Leuchter","startTime":1482.7,"endTime":1485.94,"body":"know, I had the great fortune of"},{"speaker":"Bruce Leuchter","startTime":1482.7,"endTime":1485.94,"body":"growing up in the home of a"},{"speaker":"Bruce Leuchter","startTime":1485.94,"endTime":1490.14,"body":"brilliant clinician scientist,"},{"speaker":"Bruce Leuchter","startTime":1485.94,"endTime":1490.14,"body":"neurologist, the best doctor"},{"speaker":"Bruce Leuchter","startTime":1490.14,"endTime":1495.165,"body":"I've ever known, really talented"},{"speaker":"Bruce Leuchter","startTime":1490.14,"endTime":1495.165,"body":"physician, and saw the work that"},{"speaker":"Bruce Leuchter","startTime":1495.165,"endTime":1498.225,"body":"he was doing on a daily basis."},{"speaker":"Bruce Leuchter","startTime":1495.165,"endTime":1498.225,"body":"You know, before the advent of"},{"speaker":"Bruce Leuchter","startTime":1498.525,"endTime":1502.725,"body":"digital technologies and the"},{"speaker":"Bruce Leuchter","startTime":1498.525,"endTime":1502.725,"body":"like. EEG pages strewn across"},{"speaker":"Bruce Leuchter","startTime":1502.725,"endTime":1506.085,"body":"the kitchen table, CSF samples"},{"speaker":"Bruce Leuchter","startTime":1502.725,"endTime":1506.085,"body":"in the freezer getting ready to"},{"speaker":"Bruce Leuchter","startTime":1506.085,"endTime":1509.685,"body":"go back to the office on Monday,"},{"speaker":"Bruce Leuchter","startTime":1506.085,"endTime":1509.685,"body":"go on rounds in the hospital on"},{"speaker":"Bruce Leuchter","startTime":1509.685,"endTime":1512.685,"body":"a Saturday, and saw it"},{"speaker":"Bruce Leuchter","startTime":1509.685,"endTime":1512.685,"body":"firsthand. Thought it was the"},{"speaker":"Bruce Leuchter","startTime":1513.105,"endTime":1518.31,"body":"coolest job in the world and the"},{"speaker":"Bruce Leuchter","startTime":1513.105,"endTime":1518.31,"body":"most privileged relationship"},{"speaker":"Bruce Leuchter","startTime":1518.31,"endTime":1522.93,"body":"that one could develop in the"},{"speaker":"Bruce Leuchter","startTime":1518.31,"endTime":1522.93,"body":"world. For someone who was"},{"speaker":"Bruce Leuchter","startTime":1522.93,"endTime":1526.53,"body":"interested in academics and"},{"speaker":"Bruce Leuchter","startTime":1522.93,"endTime":1526.53,"body":"science, there, in essence, was"},{"speaker":"Bruce Leuchter","startTime":1526.53,"endTime":1530.25,"body":"no other path. So while I can"},{"speaker":"Bruce Leuchter","startTime":1526.53,"endTime":1530.25,"body":"represent to you that becoming a"},{"speaker":"Bruce Leuchter","startTime":1530.25,"endTime":1534.93,"body":"physician was the narrow view I"},{"speaker":"Bruce Leuchter","startTime":1530.25,"endTime":1534.93,"body":"had of my career dating back to"},{"speaker":"Bruce Leuchter","startTime":1534.99,"endTime":1539.295,"body":"as early as I can remember, I"},{"speaker":"Bruce Leuchter","startTime":1534.99,"endTime":1539.295,"body":"can also represent to you that I"},{"speaker":"Bruce Leuchter","startTime":1539.355,"endTime":1544.935,"body":"felt pretty early on that there"},{"speaker":"Bruce Leuchter","startTime":1539.355,"endTime":1544.935,"body":"may be more to it than taking"},{"speaker":"Bruce Leuchter","startTime":1544.935,"endTime":1550.155,"body":"care of patients, as much of a"},{"speaker":"Bruce Leuchter","startTime":1544.935,"endTime":1550.155,"body":"privilege as that is. It felt"},{"speaker":"Bruce Leuchter","startTime":1550.155,"endTime":1556.035,"body":"like the ecosystem was bigger"},{"speaker":"Bruce Leuchter","startTime":1550.155,"endTime":1556.035,"body":"than that, the broader ecosystem"},{"speaker":"Bruce Leuchter","startTime":1556.035,"endTime":1558.855,"body":"of healthcare. I have a hard"},{"speaker":"Bruce Leuchter","startTime":1556.035,"endTime":1558.855,"body":"time articulating it more"},{"speaker":"Bruce Leuchter","startTime":1558.855,"endTime":1561.615,"body":"clearly, because I don't think I"},{"speaker":"Bruce Leuchter","startTime":1558.855,"endTime":1561.615,"body":"understood it any more clearly"},{"speaker":"Bruce Leuchter","startTime":1561.615,"endTime":1565.86,"body":"back in the day, but it did feel"},{"speaker":"Bruce Leuchter","startTime":1561.615,"endTime":1565.86,"body":"like there were other forces at"},{"speaker":"Bruce Leuchter","startTime":1565.86,"endTime":1570.12,"body":"play that were ultimately"},{"speaker":"Bruce Leuchter","startTime":1565.86,"endTime":1570.12,"body":"determining how a patient was"},{"speaker":"Bruce Leuchter","startTime":1570.12,"endTime":1573.18,"body":"treated by their physician, and"},{"speaker":"Bruce Leuchter","startTime":1570.12,"endTime":1573.18,"body":"that got me interested in"},{"speaker":"Bruce Leuchter","startTime":1573.18,"endTime":1578.46,"body":"managed care. I did some work at"},{"speaker":"Bruce Leuchter","startTime":1573.18,"endTime":1578.46,"body":"an HMO back in medical school. I"},{"speaker":"Bruce Leuchter","startTime":1578.46,"endTime":1582.78,"body":"saw pretty early in coming to"},{"speaker":"Bruce Leuchter","startTime":1578.46,"endTime":1582.78,"body":"New York City to train that, you"},{"speaker":"Bruce Leuchter","startTime":1582.78,"endTime":1585.645,"body":"know, you throw a stone, you hit"},{"speaker":"Bruce Leuchter","startTime":1582.78,"endTime":1585.645,"body":"two bankers in New York City and"},{"speaker":"Bruce Leuchter","startTime":1586.005,"endTime":1589.605,"body":"got close to Wall Street, but at"},{"speaker":"Bruce Leuchter","startTime":1586.005,"endTime":1589.605,"body":"a moment in time at which there"},{"speaker":"Bruce Leuchter","startTime":1589.605,"endTime":1592.845,"body":"was an enormous amount of novel"},{"speaker":"Bruce Leuchter","startTime":1589.605,"endTime":1592.845,"body":"therapeutic development. This is"},{"speaker":"Bruce Leuchter","startTime":1592.845,"endTime":1595.665,"body":"the novel anti-epileptics, the"},{"speaker":"Bruce Leuchter","startTime":1592.845,"endTime":1595.665,"body":"novel MS drugs, the pain drugs,"},{"speaker":"Bruce Leuchter","startTime":1595.665,"endTime":1599.205,"body":"the sleep drugs, all the stuff"},{"speaker":"Bruce Leuchter","startTime":1595.665,"endTime":1599.205,"body":"we currently use to treat"},{"speaker":"Bruce Leuchter","startTime":1599.205,"endTime":1601.725,"body":"patients, was happening at that"},{"speaker":"Bruce Leuchter","startTime":1599.205,"endTime":1601.725,"body":"moment in time, and there was"},{"speaker":"Bruce Leuchter","startTime":1601.725,"endTime":1605.445,"body":"just a demand for viewpoints"},{"speaker":"Bruce Leuchter","startTime":1601.725,"endTime":1605.445,"body":"from people who were in"},{"speaker":"Bruce Leuchter","startTime":1605.505,"endTime":1609.39,"body":"physician roles or academic"},{"speaker":"Bruce Leuchter","startTime":1605.505,"endTime":1609.39,"body":"roles. I found my way to that,"},{"speaker":"Bruce Leuchter","startTime":1609.75,"endTime":1612.87,"body":"and that snowballed, and here I"},{"speaker":"Bruce Leuchter","startTime":1609.75,"endTime":1612.87,"body":"am. But again, the governing"},{"speaker":"Bruce Leuchter","startTime":1612.87,"endTime":1617.49,"body":"principle being, I like to learn"},{"speaker":"Bruce Leuchter","startTime":1612.87,"endTime":1617.49,"body":"and I like to challenge myself,"},{"speaker":"Bruce Leuchter","startTime":1617.55,"endTime":1621.99,"body":"and I believe that humility is"},{"speaker":"Bruce Leuchter","startTime":1617.55,"endTime":1621.99,"body":"critical, and I believe that"},{"speaker":"Bruce Leuchter","startTime":1621.99,"endTime":1625.23,"body":"vulnerability is critical to"},{"speaker":"Bruce Leuchter","startTime":1621.99,"endTime":1625.23,"body":"learning, believe it or not,"},{"speaker":"Bruce Leuchter","startTime":1625.23,"endTime":1629.475,"body":"allowing yourself to feel"},{"speaker":"Bruce Leuchter","startTime":1625.23,"endTime":1629.475,"body":"vulnerable. And that I think"},{"speaker":"Bruce Leuchter","startTime":1629.475,"endTime":1632.355,"body":"I've believed for also as long"},{"speaker":"Bruce Leuchter","startTime":1629.475,"endTime":1632.355,"body":"as I can remember, so maybe"},{"speaker":"Bruce Leuchter","startTime":1632.355,"endTime":1635.355,"body":"there is a common thread. But at"},{"speaker":"Bruce Leuchter","startTime":1632.355,"endTime":1635.355,"body":"the end of the day, I was the"},{"speaker":"Bruce Leuchter","startTime":1635.355,"endTime":1639.975,"body":"son of a brilliant physician,"},{"speaker":"Bruce Leuchter","startTime":1635.355,"endTime":1639.975,"body":"and I was beelining straight to"},{"speaker":"Bruce Leuchter","startTime":1640.155,"endTime":1641.415,"body":"medical school."},{"speaker":"John Simboli","startTime":1641.0,"endTime":1643.22,"body":"who is Neurvati"},{"speaker":"John Simboli","startTime":1641.0,"endTime":1643.22,"body":"Neurosciences?"},{"speaker":"Bruce Leuchter","startTime":1643.72,"endTime":1649.06,"body":"I tell people,"},{"speaker":"Bruce Leuchter","startTime":1643.72,"endTime":1649.06,"body":"our job is to identify and"},{"speaker":"Bruce Leuchter","startTime":1649.06,"endTime":1653.14,"body":"develop novel therapeutics for"},{"speaker":"Bruce Leuchter","startTime":1649.06,"endTime":1653.14,"body":"diseases of the brain and"},{"speaker":"Bruce Leuchter","startTime":1653.14,"endTime":1656.92,"body":"nervous system. I think most"},{"speaker":"Bruce Leuchter","startTime":1653.14,"endTime":1656.92,"body":"people, whether they're close to"},{"speaker":"Bruce Leuchter","startTime":1656.92,"endTime":1660.46,"body":"biotech or far from it,"},{"speaker":"Bruce Leuchter","startTime":1656.92,"endTime":1660.46,"body":"appreciate that, understand"},{"speaker":"Bruce Leuchter","startTime":1660.46,"endTime":1664.6,"body":"that. We do it in a way that is"},{"speaker":"Bruce Leuchter","startTime":1660.46,"endTime":1664.6,"body":"different than a standard"},{"speaker":"Bruce Leuchter","startTime":1664.66,"endTime":1667.54,"body":"biotech company does, just given"},{"speaker":"Bruce Leuchter","startTime":1664.66,"endTime":1667.54,"body":"our relationship with Blackstone"},{"speaker":"Bruce Leuchter","startTime":1667.54,"endTime":1670.165,"body":"Life Sciences, how they finance"},{"speaker":"Bruce Leuchter","startTime":1667.54,"endTime":1670.165,"body":"the work we do, and how they"},{"speaker":"Bruce Leuchter","startTime":1670.165,"endTime":1674.665,"body":"partner with us on it. Also"},{"speaker":"Bruce Leuchter","startTime":1670.165,"endTime":1674.665,"body":"different in terms of the way in"},{"speaker":"Bruce Leuchter","startTime":1674.665,"endTime":1678.685,"body":"which we innovate, where we look"},{"speaker":"Bruce Leuchter","startTime":1674.665,"endTime":1678.685,"body":"for programs that are going to"},{"speaker":"Bruce Leuchter","startTime":1678.685,"endTime":1683.065,"body":"be externalized from established"},{"speaker":"Bruce Leuchter","startTime":1678.685,"endTime":1683.065,"body":"companies, determine whether or"},{"speaker":"Bruce Leuchter","startTime":1683.065,"endTime":1686.365,"body":"not there's any hazard around"},{"speaker":"Bruce Leuchter","startTime":1683.065,"endTime":1686.365,"body":"that decision to externalize."},{"speaker":"Bruce Leuchter","startTime":1686.365,"endTime":1689.785,"body":"Often there is not. Often there"},{"speaker":"Bruce Leuchter","startTime":1686.365,"endTime":1689.785,"body":"is just the need to prune"},{"speaker":"Bruce Leuchter","startTime":1689.785,"endTime":1693.13,"body":"portfolios, to rethink"},{"speaker":"Bruce Leuchter","startTime":1689.785,"endTime":1693.13,"body":"strategies in certain"},{"speaker":"Bruce Leuchter","startTime":1693.13,"endTime":1696.37,"body":"therapeutic areas, less of a"},{"speaker":"Bruce Leuchter","startTime":1693.13,"endTime":1696.37,"body":"commentary on an individual"},{"speaker":"Bruce Leuchter","startTime":1696.37,"endTime":1699.01,"body":"program, more of a commentary on"},{"speaker":"Bruce Leuchter","startTime":1696.37,"endTime":1699.01,"body":"an overarching corporate"},{"speaker":"Bruce Leuchter","startTime":1699.01,"endTime":1704.65,"body":"strategy. And we, because of our"},{"speaker":"Bruce Leuchter","startTime":1699.01,"endTime":1704.65,"body":"relationships, both at the"},{"speaker":"Bruce Leuchter","startTime":1704.65,"endTime":1707.23,"body":"Neurvati co level, given"},{"speaker":"Bruce Leuchter","startTime":1704.65,"endTime":1707.23,"body":"everything that each of the"},{"speaker":"Bruce Leuchter","startTime":1707.23,"endTime":1709.51,"body":"senior leaders have done in"},{"speaker":"Bruce Leuchter","startTime":1707.23,"endTime":1709.51,"body":"their careers, and at Blackstone"},{"speaker":"Bruce Leuchter","startTime":1709.51,"endTime":1712.27,"body":"Life Sciences, the network is"},{"speaker":"Bruce Leuchter","startTime":1709.51,"endTime":1712.27,"body":"quite large, and so we find"},{"speaker":"Bruce Leuchter","startTime":1712.27,"endTime":1715.195,"body":"ourselves in bespoke"},{"speaker":"Bruce Leuchter","startTime":1712.27,"endTime":1715.195,"body":"conversations with the world's"},{"speaker":"Bruce Leuchter","startTime":1715.195,"endTime":1718.495,"body":"largest pharma companies and,"},{"speaker":"Bruce Leuchter","startTime":1715.195,"endTime":1718.495,"body":"for that matter, small privately"},{"speaker":"Bruce Leuchter","startTime":1718.495,"endTime":1721.855,"body":"held pharma companies or biotech"},{"speaker":"Bruce Leuchter","startTime":1718.495,"endTime":1721.855,"body":"companies, where there is a"},{"speaker":"Bruce Leuchter","startTime":1721.855,"endTime":1725.155,"body":"need, there is a need for"},{"speaker":"Bruce Leuchter","startTime":1721.855,"endTime":1725.155,"body":"operational expertise, there is"},{"speaker":"Bruce Leuchter","startTime":1725.155,"endTime":1728.875,"body":"a need for alternative"},{"speaker":"Bruce Leuchter","startTime":1725.155,"endTime":1728.875,"body":"financing. And we identify those"},{"speaker":"Bruce Leuchter","startTime":1728.875,"endTime":1732.295,"body":"programs, we diligence them in"},{"speaker":"Bruce Leuchter","startTime":1728.875,"endTime":1732.295,"body":"an incredibly robust way, in a"},{"speaker":"Bruce Leuchter","startTime":1732.295,"endTime":1737.8,"body":"manner that I'm quite proud of,"},{"speaker":"Bruce Leuchter","startTime":1732.295,"endTime":1737.8,"body":"the level of detail, the embrace"},{"speaker":"Bruce Leuchter","startTime":1737.8,"endTime":1740.02,"body":"of the science, the"},{"speaker":"Bruce Leuchter","startTime":1737.8,"endTime":1740.02,"body":"understanding of the clinical"},{"speaker":"Bruce Leuchter","startTime":1740.02,"endTime":1743.08,"body":"development that we need to do,"},{"speaker":"Bruce Leuchter","startTime":1740.02,"endTime":1743.08,"body":"the regulatory path that  we'll"},{"speaker":"Bruce Leuchter","startTime":1743.08,"endTime":1746.98,"body":"pursue, the markets that we aim"},{"speaker":"Bruce Leuchter","startTime":1743.08,"endTime":1746.98,"body":"to target, and then we find our"},{"speaker":"Bruce Leuchter","startTime":1746.98,"endTime":1750.64,"body":"way toward establishing a new"},{"speaker":"Bruce Leuchter","startTime":1746.98,"endTime":1750.64,"body":"special purpose vehicle, or"},{"speaker":"Bruce Leuchter","startTime":1750.64,"endTime":1753.94,"body":"affiliate co and then"},{"speaker":"Bruce Leuchter","startTime":1750.64,"endTime":1753.94,"body":"progressing it into late and"},{"speaker":"Bruce Leuchter","startTime":1753.94,"endTime":1756.82,"body":"through late stage development"},{"speaker":"Bruce Leuchter","startTime":1753.94,"endTime":1756.82,"body":"to approval. So again, the"},{"speaker":"Bruce Leuchter","startTime":1756.82,"endTime":1759.1,"body":"easiest way to say it is we"},{"speaker":"Bruce Leuchter","startTime":1756.82,"endTime":1759.1,"body":"develop neuroscience"},{"speaker":"Bruce Leuchter","startTime":1759.1,"endTime":1762.685,"body":"therapeutics, and we do it in a"},{"speaker":"Bruce Leuchter","startTime":1759.1,"endTime":1762.685,"body":"way that leverages the"},{"speaker":"Bruce Leuchter","startTime":1762.685,"endTime":1765.985,"body":"operational capabilities that we"},{"speaker":"Bruce Leuchter","startTime":1762.685,"endTime":1765.985,"body":"have and the financial backing"},{"speaker":"Bruce Leuchter","startTime":1765.985,"endTime":1767.185,"body":"that we have from our partner,"},{"speaker":"John Simboli","startTime":1767.0,"endTime":1769.82,"body":"Let's say that at"},{"speaker":"John Simboli","startTime":1767.0,"endTime":1769.82,"body":"an investor conference, and you"},{"speaker":"John Simboli","startTime":1769.82,"endTime":1772.64,"body":"begin to give the description of"},{"speaker":"John Simboli","startTime":1769.82,"endTime":1772.64,"body":"who you are as a company, as"},{"speaker":"John Simboli","startTime":1772.64,"endTime":1776.66,"body":"you've been giving it to me, and"},{"speaker":"John Simboli","startTime":1772.64,"endTime":1776.66,"body":"you get that moment when someone"},{"speaker":"John Simboli","startTime":1776.72,"endTime":1780.86,"body":"wants to put your company, into"},{"speaker":"John Simboli","startTime":1776.72,"endTime":1780.86,"body":"a particular category. And"},{"speaker":"John Simboli","startTime":1780.92,"endTime":1783.86,"body":"sometimes it's the right one,"},{"speaker":"John Simboli","startTime":1780.92,"endTime":1783.86,"body":"sometimes it's wrong one. It's"},{"speaker":"John Simboli","startTime":1783.86,"endTime":1788.48,"body":"been my experience that often"},{"speaker":"John Simboli","startTime":1783.86,"endTime":1788.48,"body":"the CEO's job is to help to"},{"speaker":"John Simboli","startTime":1788.48,"endTime":1792.365,"body":"educate at that point so that"},{"speaker":"John Simboli","startTime":1788.48,"endTime":1792.365,"body":"you know they don't get stuck in"},{"speaker":"John Simboli","startTime":1792.365,"endTime":1799.205,"body":"the wrong spot. So are there"},{"speaker":"John Simboli","startTime":1792.365,"endTime":1799.205,"body":"wrong spots that Neurvati would"},{"speaker":"John Simboli","startTime":1799.205,"endTime":1801.905,"body":"get placed into? And if there"},{"speaker":"John Simboli","startTime":1799.205,"endTime":1801.905,"body":"are, what are they? What is that"},{"speaker":"John Simboli","startTime":1801.905,"endTime":1804.905,"body":"pattern? And then how do you"},{"speaker":"John Simboli","startTime":1801.905,"endTime":1804.905,"body":"help get out of that pattern?"},{"speaker":"John Simboli","startTime":1804.905,"endTime":1805.145,"body":"think"},{"speaker":"Bruce Leuchter","startTime":1805.0,"endTime":1809.5,"body":"I think our"},{"speaker":"Bruce Leuchter","startTime":1805.0,"endTime":1809.5,"body":"model requires explanation."},{"speaker":"Bruce Leuchter","startTime":1809.68,"endTime":1814.0,"body":"Because as much as we develop"},{"speaker":"Bruce Leuchter","startTime":1809.68,"endTime":1814.0,"body":"mid to late stage therapeutics,"},{"speaker":"Bruce Leuchter","startTime":1814.3,"endTime":1817.3,"body":"there are unique features that I"},{"speaker":"Bruce Leuchter","startTime":1814.3,"endTime":1817.3,"body":"think people need to understand,"},{"speaker":"Bruce Leuchter","startTime":1817.3,"endTime":1820.72,"body":"for them to fully appreciate"},{"speaker":"Bruce Leuchter","startTime":1817.3,"endTime":1820.72,"body":"what our mandate is and how we"},{"speaker":"Bruce Leuchter","startTime":1820.72,"endTime":1824.5,"body":"do it. We certainly want people"},{"speaker":"Bruce Leuchter","startTime":1820.72,"endTime":1824.5,"body":"focused on the affiliate co work"},{"speaker":"Bruce Leuchter","startTime":1824.5,"endTime":1827.715,"body":"that we do, particularly where"},{"speaker":"Bruce Leuchter","startTime":1824.5,"endTime":1827.715,"body":"we are right now with GRIN"},{"speaker":"Bruce Leuchter","startTime":1827.715,"endTime":1829.525,"body":"Therapeutics, heading into a"},{"speaker":"Bruce Leuchter","startTime":1827.715,"endTime":1829.525,"body":"phase three study, there's all"},{"speaker":"Bruce Leuchter","startTime":1829.525,"endTime":1832.525,"body":"kinds of motivation around"},{"speaker":"Bruce Leuchter","startTime":1829.525,"endTime":1832.525,"body":"educating the stakeholder,"},{"speaker":"Bruce Leuchter","startTime":1832.525,"endTime":1838.465,"body":"community, investors, strategics"},{"speaker":"Bruce Leuchter","startTime":1832.525,"endTime":1838.465,"body":"and others, on how promising"},{"speaker":"Bruce Leuchter","startTime":1838.465,"endTime":1841.525,"body":"this development stage"},{"speaker":"Bruce Leuchter","startTime":1838.465,"endTime":1841.525,"body":"therapeutic is and how focused"},{"speaker":"Bruce Leuchter","startTime":1841.525,"endTime":1844.705,"body":"we are on progressing the ball"},{"speaker":"Bruce Leuchter","startTime":1841.525,"endTime":1844.705,"body":"down the field and gaining"},{"speaker":"Bruce Leuchter","startTime":1844.705,"endTime":1847.165,"body":"approval, ultimately, and"},{"speaker":"Bruce Leuchter","startTime":1844.705,"endTime":1847.165,"body":"delivering it to patients. So we"},{"speaker":"Bruce Leuchter","startTime":1847.165,"endTime":1850.765,"body":"want the spotlight on the"},{"speaker":"Bruce Leuchter","startTime":1847.165,"endTime":1850.765,"body":"affiliate co. But we also want"},{"speaker":"Bruce Leuchter","startTime":1850.765,"endTime":1855.31,"body":"people to understand that away"},{"speaker":"Bruce Leuchter","startTime":1850.765,"endTime":1855.31,"body":"from the affiliate co are all of"},{"speaker":"Bruce Leuchter","startTime":1855.31,"endTime":1858.91,"body":"these capabilities that can be"},{"speaker":"Bruce Leuchter","startTime":1855.31,"endTime":1858.91,"body":"leveraged against a very broad"},{"speaker":"Bruce Leuchter","startTime":1858.91,"endTime":1863.89,"body":"swath of neuroscience. I think"},{"speaker":"Bruce Leuchter","startTime":1858.91,"endTime":1863.89,"body":"typically when people think"},{"speaker":"Bruce Leuchter","startTime":1863.89,"endTime":1867.31,"body":"about biotech companies, they"},{"speaker":"Bruce Leuchter","startTime":1863.89,"endTime":1867.31,"body":"think about those companies"},{"speaker":"Bruce Leuchter","startTime":1867.31,"endTime":1871.39,"body":"pursuing perhaps one or two"},{"speaker":"Bruce Leuchter","startTime":1867.31,"endTime":1871.39,"body":"verticals within a given"},{"speaker":"Bruce Leuchter","startTime":1871.39,"endTime":1874.15,"body":"therapeutic area. So if you're"},{"speaker":"Bruce Leuchter","startTime":1871.39,"endTime":1874.15,"body":"developing a drug for"},{"speaker":"Bruce Leuchter","startTime":1874.15,"endTime":1876.655,"body":"psychiatric indications, you"},{"speaker":"Bruce Leuchter","startTime":1874.15,"endTime":1876.655,"body":"likely organize around"},{"speaker":"Bruce Leuchter","startTime":1876.655,"endTime":1879.055,"body":"additional psychiatric"},{"speaker":"Bruce Leuchter","startTime":1876.655,"endTime":1879.055,"body":"indications. If you're"},{"speaker":"Bruce Leuchter","startTime":1879.055,"endTime":1881.635,"body":"developing a drug against a"},{"speaker":"Bruce Leuchter","startTime":1879.055,"endTime":1881.635,"body":"neuroinflammatory disease,"},{"speaker":"Bruce Leuchter","startTime":1881.695,"endTime":1884.875,"body":"you're organizing around broader"},{"speaker":"Bruce Leuchter","startTime":1881.695,"endTime":1884.875,"body":"neuroinflammatory diseases or"},{"speaker":"Bruce Leuchter","startTime":1884.875,"endTime":1888.535,"body":"adjacent indications. And what's"},{"speaker":"Bruce Leuchter","startTime":1884.875,"endTime":1888.535,"body":"different about us is that we"},{"speaker":"Bruce Leuchter","startTime":1888.655,"endTime":1892.435,"body":"are not restricted to a given"},{"speaker":"Bruce Leuchter","startTime":1888.655,"endTime":1892.435,"body":"number of verticals. It's really"},{"speaker":"Bruce Leuchter","startTime":1892.435,"endTime":1895.735,"body":"important that people understand"},{"speaker":"Bruce Leuchter","startTime":1892.435,"endTime":1895.735,"body":"that, because what we want folks"},{"speaker":"Bruce Leuchter","startTime":1895.735,"endTime":1899.26,"body":"to appreciate is that we have"},{"speaker":"Bruce Leuchter","startTime":1895.735,"endTime":1899.26,"body":"the ability to look across the"},{"speaker":"Bruce Leuchter","startTime":1899.26,"endTime":1903.34,"body":"waterfront of neuroscience, and"},{"speaker":"Bruce Leuchter","startTime":1899.26,"endTime":1903.34,"body":"even though we are sitting here"},{"speaker":"Bruce Leuchter","startTime":1903.34,"endTime":1905.98,"body":"today talking about"},{"speaker":"Bruce Leuchter","startTime":1903.34,"endTime":1905.98,"body":"neurodevelopmental disease for"},{"speaker":"Bruce Leuchter","startTime":1905.98,"endTime":1909.64,"body":"GRIN Therapeutics and wanting"},{"speaker":"Bruce Leuchter","startTime":1905.98,"endTime":1909.64,"body":"people to understand what it is"},{"speaker":"Bruce Leuchter","startTime":1909.64,"endTime":1913.78,"body":"that we do around radiprodil in"},{"speaker":"Bruce Leuchter","startTime":1909.64,"endTime":1913.78,"body":"these diseases, we also want"},{"speaker":"Bruce Leuchter","startTime":1913.78,"endTime":1918.04,"body":"people to realize that if there"},{"speaker":"Bruce Leuchter","startTime":1913.78,"endTime":1918.04,"body":"are opportunities away from"},{"speaker":"Bruce Leuchter","startTime":1918.04,"endTime":1921.76,"body":"neurodevelopmental disease or"},{"speaker":"Bruce Leuchter","startTime":1918.04,"endTime":1921.76,"body":"away from orphan neurology that"},{"speaker":"Bruce Leuchter","startTime":1921.805,"endTime":1927.985,"body":"are focused on sleep/wake as an"},{"speaker":"Bruce Leuchter","startTime":1921.805,"endTime":1927.985,"body":"example, or focused on pain, or,"},{"speaker":"Bruce Leuchter","startTime":1927.985,"endTime":1931.165,"body":"for that matter, neuro oncology,"},{"speaker":"Bruce Leuchter","startTime":1927.985,"endTime":1931.165,"body":"glioblastomas, or malignant"},{"speaker":"Bruce Leuchter","startTime":1931.165,"endTime":1935.185,"body":"brain tumors, that we have an"},{"speaker":"Bruce Leuchter","startTime":1931.165,"endTime":1935.185,"body":"opportunity because of our"},{"speaker":"Bruce Leuchter","startTime":1935.185,"endTime":1939.385,"body":"sponsor, to go think about those"},{"speaker":"Bruce Leuchter","startTime":1935.185,"endTime":1939.385,"body":"diseases, apply the same amount"},{"speaker":"Bruce Leuchter","startTime":1939.385,"endTime":1942.565,"body":"of rigor, deliver the same kind"},{"speaker":"Bruce Leuchter","startTime":1939.385,"endTime":1942.565,"body":"of best-in-class work product"},{"speaker":"Bruce Leuchter","startTime":1942.565,"endTime":1946.81,"body":"around its viability, and if we"},{"speaker":"Bruce Leuchter","startTime":1942.565,"endTime":1946.81,"body":"get there, pursue it, even"},{"speaker":"Bruce Leuchter","startTime":1946.81,"endTime":1950.35,"body":"though one would argue that"},{"speaker":"Bruce Leuchter","startTime":1946.81,"endTime":1950.35,"body":"neuro oncology is very different"},{"speaker":"Bruce Leuchter","startTime":1950.35,"endTime":1953.59,"body":"than neurodevelopmental disease."},{"speaker":"Bruce Leuchter","startTime":1950.35,"endTime":1953.59,"body":"And we think that's okay,"},{"speaker":"Bruce Leuchter","startTime":1953.95,"endTime":1958.99,"body":"because, in our view, what the"},{"speaker":"Bruce Leuchter","startTime":1953.95,"endTime":1958.99,"body":"space really needs is champions"},{"speaker":"Bruce Leuchter","startTime":1959.35,"endTime":1964.09,"body":"for viable drug candidates,"},{"speaker":"Bruce Leuchter","startTime":1959.35,"endTime":1964.09,"body":"viable therapeutic candidates."},{"speaker":"Bruce Leuchter","startTime":1964.09,"endTime":1969.115,"body":"It needs to have people who are"},{"speaker":"Bruce Leuchter","startTime":1964.09,"endTime":1969.115,"body":"willing to roll up sleeves, get"},{"speaker":"Bruce Leuchter","startTime":1969.115,"endTime":1973.675,"body":"into the weeds, make careful"},{"speaker":"Bruce Leuchter","startTime":1969.115,"endTime":1973.675,"body":"decisions around what's best for"},{"speaker":"Bruce Leuchter","startTime":1973.675,"endTime":1977.215,"body":"any given program, and not be"},{"speaker":"Bruce Leuchter","startTime":1973.675,"endTime":1977.215,"body":"restricted to a given vertical"},{"speaker":"Bruce Leuchter","startTime":1977.215,"endTime":1979.915,"body":"within neuroscience. Because at"},{"speaker":"Bruce Leuchter","startTime":1977.215,"endTime":1979.915,"body":"the end of the day, we want to"},{"speaker":"Bruce Leuchter","startTime":1979.915,"endTime":1984.295,"body":"take clinical stage product"},{"speaker":"Bruce Leuchter","startTime":1979.915,"endTime":1984.295,"body":"candidates, properly resource"},{"speaker":"Bruce Leuchter","startTime":1984.295,"endTime":1989.695,"body":"them, deliver the ultimate data"},{"speaker":"Bruce Leuchter","startTime":1984.295,"endTime":1989.695,"body":"point, gain approval, and find"},{"speaker":"Bruce Leuchter","startTime":1990.235,"endTime":1993.58,"body":"our way to patients through"},{"speaker":"Bruce Leuchter","startTime":1990.235,"endTime":1993.58,"body":"whatever mechanism. Could be us"},{"speaker":"Bruce Leuchter","startTime":1993.64,"endTime":1996.64,"body":"commercializing the drug. Could"},{"speaker":"Bruce Leuchter","startTime":1993.64,"endTime":1996.64,"body":"be us putting it in the hands of"},{"speaker":"Bruce Leuchter","startTime":1996.64,"endTime":1999.16,"body":"a vertically integrated"},{"speaker":"Bruce Leuchter","startTime":1996.64,"endTime":1999.16,"body":"organization that is already"},{"speaker":"Bruce Leuchter","startTime":1999.16,"endTime":2002.04,"body":"commercializing against the same"},{"speaker":"Bruce Leuchter","startTime":1999.16,"endTime":2002.04,"body":"call point, against the same"},{"speaker":"Bruce Leuchter","startTime":2002.04,"endTime":2006.18,"body":"position. And what we've noted,"},{"speaker":"Bruce Leuchter","startTime":2002.04,"endTime":2006.18,"body":"this is a very generic comment"},{"speaker":"Bruce Leuchter","startTime":2006.18,"endTime":2010.02,"body":"to all of our peers across the"},{"speaker":"Bruce Leuchter","startTime":2006.18,"endTime":2010.02,"body":"biopharma landscape., but what"},{"speaker":"Bruce Leuchter","startTime":2010.02,"endTime":2013.185,"body":"we've noted is that it's not"},{"speaker":"Bruce Leuchter","startTime":2010.02,"endTime":2013.185,"body":"always true that you can work on"},{"speaker":"Bruce Leuchter","startTime":2013.185,"endTime":2017.565,"body":"everything that you want to work"},{"speaker":"Bruce Leuchter","startTime":2013.185,"endTime":2017.565,"body":"on. And in some cases, despite a"},{"speaker":"Bruce Leuchter","startTime":2017.565,"endTime":2021.045,"body":"product candidate being"},{"speaker":"Bruce Leuchter","startTime":2017.565,"endTime":2021.045,"body":"perfectly viable, fundamentally,"},{"speaker":"Bruce Leuchter","startTime":2021.525,"endTime":2025.905,"body":"there are reasons for companies"},{"speaker":"Bruce Leuchter","startTime":2021.525,"endTime":2025.905,"body":"to externalize or terminate"},{"speaker":"Bruce Leuchter","startTime":2025.905,"endTime":2028.425,"body":"their own resource allocation"},{"speaker":"Bruce Leuchter","startTime":2025.905,"endTime":2028.425,"body":"against that program. And"},{"speaker":"Bruce Leuchter","startTime":2028.425,"endTime":2031.005,"body":"because we're not restricted to"},{"speaker":"Bruce Leuchter","startTime":2028.425,"endTime":2031.005,"body":"any of these given verticals,"},{"speaker":"Bruce Leuchter","startTime":2031.005,"endTime":2036.03,"body":"per se, we can take that robust"},{"speaker":"Bruce Leuchter","startTime":2031.005,"endTime":2036.03,"body":"data set and we can create value"},{"speaker":"Bruce Leuchter","startTime":2036.03,"endTime":2038.31,"body":"around it. We can progress the"},{"speaker":"Bruce Leuchter","startTime":2036.03,"endTime":2038.31,"body":"ball down the field in a way"},{"speaker":"Bruce Leuchter","startTime":2038.31,"endTime":2042.33,"body":"that one may not have otherwise"},{"speaker":"Bruce Leuchter","startTime":2038.31,"endTime":2042.33,"body":"been able to do. And that's a"},{"speaker":"Bruce Leuchter","startTime":2042.33,"endTime":2046.17,"body":"privilege, and so we want people"},{"speaker":"Bruce Leuchter","startTime":2042.33,"endTime":2046.17,"body":"to know that. That is, if I had"},{"speaker":"Bruce Leuchter","startTime":2046.17,"endTime":2048.57,"body":"to argue that there's one"},{"speaker":"Bruce Leuchter","startTime":2046.17,"endTime":2048.57,"body":"distinct difference between us"},{"speaker":"Bruce Leuchter","startTime":2048.57,"endTime":2054.09,"body":"and others, is that our common"},{"speaker":"Bruce Leuchter","startTime":2048.57,"endTime":2054.09,"body":"denominator is data, is"},{"speaker":"Bruce Leuchter","startTime":2054.09,"endTime":2058.05,"body":"robustness of clinical data"},{"speaker":"Bruce Leuchter","startTime":2054.09,"endTime":2058.05,"body":"sets, and what that is allowing"},{"speaker":"Bruce Leuchter","startTime":2058.05,"endTime":2062.655,"body":"us to believe about downstream"},{"speaker":"Bruce Leuchter","startTime":2058.05,"endTime":2062.655,"body":"success. It is not restricted to"},{"speaker":"Bruce Leuchter","startTime":2062.655,"endTime":2065.715,"body":"a view on a certain vertical of"},{"speaker":"Bruce Leuchter","startTime":2062.655,"endTime":2065.715,"body":"neuroscience."},{"speaker":"John Simboli","startTime":2065.18,"endTime":2069.5,"body":"It would seem that"},{"speaker":"John Simboli","startTime":2065.18,"endTime":2069.5,"body":"that would take a sophisticated"},{"speaker":"John Simboli","startTime":2070.4,"endTime":2075.14,"body":"partner to absorb that and"},{"speaker":"John Simboli","startTime":2070.4,"endTime":2075.14,"body":"understand that. On the other"},{"speaker":"John Simboli","startTime":2075.14,"endTime":2078.02,"body":"hand, it would seem it could be"},{"speaker":"John Simboli","startTime":2075.14,"endTime":2078.02,"body":"breathtaking in the right"},{"speaker":"John Simboli","startTime":2079.1,"endTime":2082.52,"body":"conversation. Is that a fair"},{"speaker":"John Simboli","startTime":2079.1,"endTime":2082.52,"body":"statement?"},{"speaker":"Bruce Leuchter","startTime":2082.84,"endTime":2085.06,"body":"It's a fair"},{"speaker":"Bruce Leuchter","startTime":2082.84,"endTime":2085.06,"body":"statement. I think the ambition"},{"speaker":"Bruce Leuchter","startTime":2085.12,"endTime":2089.98,"body":"level is high when one tries to"},{"speaker":"Bruce Leuchter","startTime":2085.12,"endTime":2089.98,"body":"tackle, you know, an entire"},{"speaker":"Bruce Leuchter","startTime":2089.98,"endTime":2093.46,"body":"therapeutic area the size of"},{"speaker":"Bruce Leuchter","startTime":2089.98,"endTime":2093.46,"body":"neuroscience. And what we've"},{"speaker":"Bruce Leuchter","startTime":2093.46,"endTime":2097.24,"body":"done as an organization is"},{"speaker":"Bruce Leuchter","startTime":2093.46,"endTime":2097.24,"body":"remain relatively lean,"},{"speaker":"Bruce Leuchter","startTime":2097.48,"endTime":2100.12,"body":"certainly relative to other"},{"speaker":"Bruce Leuchter","startTime":2097.48,"endTime":2100.12,"body":"companies heading into Phase 3"},{"speaker":"Bruce Leuchter","startTime":2100.12,"endTime":2103.6,"body":"studies, and we've done that for"},{"speaker":"Bruce Leuchter","startTime":2100.12,"endTime":2103.6,"body":"a reason. We're certainly fit"},{"speaker":"Bruce Leuchter","startTime":2103.6,"endTime":2108.025,"body":"for purpose. We've got all the"},{"speaker":"Bruce Leuchter","startTime":2103.6,"endTime":2108.025,"body":"capabilities and muscle that we"},{"speaker":"Bruce Leuchter","startTime":2108.025,"endTime":2111.445,"body":"need to progress our programs,"},{"speaker":"Bruce Leuchter","startTime":2108.025,"endTime":2111.445,"body":"but we know that the next"},{"speaker":"Bruce Leuchter","startTime":2111.445,"endTime":2114.985,"body":"opportunity we work on may"},{"speaker":"Bruce Leuchter","startTime":2111.445,"endTime":2114.985,"body":"require slightly different"},{"speaker":"Bruce Leuchter","startTime":2115.045,"endTime":2118.105,"body":"expertise, that may require a"},{"speaker":"Bruce Leuchter","startTime":2115.045,"endTime":2118.105,"body":"different fit for purpose view"},{"speaker":"Bruce Leuchter","startTime":2118.165,"endTime":2121.945,"body":"on who we hire and who organizes"},{"speaker":"Bruce Leuchter","startTime":2118.165,"endTime":2121.945,"body":"around that next project. And"},{"speaker":"Bruce Leuchter","startTime":2122.065,"endTime":2124.825,"body":"they're going to be plenty of"},{"speaker":"Bruce Leuchter","startTime":2122.065,"endTime":2124.825,"body":"people who organize around all"},{"speaker":"Bruce Leuchter","startTime":2124.825,"endTime":2127.825,"body":"projects that we take on, but"},{"speaker":"Bruce Leuchter","startTime":2124.825,"endTime":2127.825,"body":"there may be more bespoke"},{"speaker":"Bruce Leuchter","startTime":2128.05,"endTime":2131.95,"body":"expertise and capabilities that"},{"speaker":"Bruce Leuchter","startTime":2128.05,"endTime":2131.95,"body":"are mandated, required in order"},{"speaker":"Bruce Leuchter","startTime":2131.95,"endTime":2134.17,"body":"for us to succeed in the next"},{"speaker":"Bruce Leuchter","startTime":2131.95,"endTime":2134.17,"body":"affiliate co, we've got the"},{"speaker":"Bruce Leuchter","startTime":2134.17,"endTime":2137.23,"body":"opportunity to bring those folks"},{"speaker":"Bruce Leuchter","startTime":2134.17,"endTime":2137.23,"body":"in. So we don't believe, as I"},{"speaker":"Bruce Leuchter","startTime":2137.41,"endTime":2140.71,"body":"said earlier in the"},{"speaker":"Bruce Leuchter","startTime":2137.41,"endTime":2140.71,"body":"conversation, no one's good at"},{"speaker":"Bruce Leuchter","startTime":2140.71,"endTime":2144.91,"body":"everything. Expertise are called"},{"speaker":"Bruce Leuchter","startTime":2140.71,"endTime":2144.91,"body":"expertise for a reason. And as"},{"speaker":"Bruce Leuchter","startTime":2144.91,"endTime":2146.95,"body":"we organize around"},{"speaker":"Bruce Leuchter","startTime":2144.91,"endTime":2146.95,"body":"opportunities, we look for the"},{"speaker":"Bruce Leuchter","startTime":2146.95,"endTime":2150.13,"body":"best expertise that will give us"},{"speaker":"Bruce Leuchter","startTime":2146.95,"endTime":2150.13,"body":"the highest probability of"},{"speaker":"Bruce Leuchter","startTime":2150.13,"endTime":2153.115,"body":"succeeding around that affiliate"},{"speaker":"Bruce Leuchter","startTime":2150.13,"endTime":2153.115,"body":"co. And that's what our model"},{"speaker":"Bruce Leuchter","startTime":2153.115,"endTime":2153.715,"body":"has enabled."},{"speaker":"John Simboli","startTime":2154.5,"endTime":2157.74,"body":"If GRIN succeeds"},{"speaker":"John Simboli","startTime":2154.5,"endTime":2157.74,"body":"the way you hope it will, do you"},{"speaker":"John Simboli","startTime":2157.74,"endTime":2163.5,"body":"allow yourself, at this point to"},{"speaker":"John Simboli","startTime":2157.74,"endTime":2163.5,"body":"picture how transformational"},{"speaker":"John Simboli","startTime":2163.92,"endTime":2167.28,"body":"your therapeutic might be, and"},{"speaker":"John Simboli","startTime":2163.92,"endTime":2167.28,"body":"what is the need? What's not"},{"speaker":"John Simboli","startTime":2167.28,"endTime":2171.54,"body":"being served? Just how could you"},{"speaker":"John Simboli","startTime":2167.28,"endTime":2171.54,"body":"change the equation?"},{"speaker":"Bruce Leuchter","startTime":2171.9,"endTime":2177.18,"body":"Important"},{"speaker":"Bruce Leuchter","startTime":2171.9,"endTime":2177.18,"body":"question. We believe that we"},{"speaker":"Bruce Leuchter","startTime":2177.18,"endTime":2181.14,"body":"have an opportunity to"},{"speaker":"Bruce Leuchter","startTime":2177.18,"endTime":2181.14,"body":"materially impact the lives of"},{"speaker":"Bruce Leuchter","startTime":2181.26,"endTime":2185.58,"body":"patients, caregivers and"},{"speaker":"Bruce Leuchter","startTime":2181.26,"endTime":2185.58,"body":"families in a way that hasn't"},{"speaker":"Bruce Leuchter","startTime":2185.58,"endTime":2190.44,"body":"yet been done. So it is very"},{"speaker":"Bruce Leuchter","startTime":2185.58,"endTime":2190.44,"body":"true and important to note that"},{"speaker":"Bruce Leuchter","startTime":2190.44,"endTime":2194.4,"body":"companies have had significant"},{"speaker":"Bruce Leuchter","startTime":2190.44,"endTime":2194.4,"body":"success around rare pediatric"},{"speaker":"Bruce Leuchter","startTime":2194.4,"endTime":2196.725,"body":"epilepsies and"},{"speaker":"Bruce Leuchter","startTime":2194.4,"endTime":2196.725,"body":"neurodevelopmental diseases,"},{"speaker":"Bruce Leuchter","startTime":2196.725,"endTime":2199.605,"body":"particularly over the last 10"},{"speaker":"Bruce Leuchter","startTime":2196.725,"endTime":2199.605,"body":"years, where I would argue human"},{"speaker":"Bruce Leuchter","startTime":2200.565,"endTime":2203.865,"body":"genetics have enabled more"},{"speaker":"Bruce Leuchter","startTime":2200.565,"endTime":2203.865,"body":"definitive diagnosis awareness,"},{"speaker":"Bruce Leuchter","startTime":2203.865,"endTime":2208.005,"body":"visibility of these diseases has"},{"speaker":"Bruce Leuchter","startTime":2203.865,"endTime":2208.005,"body":"increased, and the tide in"},{"speaker":"Bruce Leuchter","startTime":2208.005,"endTime":2212.985,"body":"general has been rising. But the"},{"speaker":"Bruce Leuchter","startTime":2208.005,"endTime":2212.985,"body":"success to this point has been"},{"speaker":"Bruce Leuchter","startTime":2212.985,"endTime":2216.585,"body":"largely around treating symptoms"},{"speaker":"Bruce Leuchter","startTime":2212.985,"endTime":2216.585,"body":"of disease, not treating the"},{"speaker":"Bruce Leuchter","startTime":2216.585,"endTime":2216.779,"body":"underlying disease biology, in"},{"speaker":"Bruce Leuchter","startTime":2216.585,"endTime":2216.779,"body":"this particular part of the of"},{"speaker":"Bruce Leuchter","startTime":2216.779,"endTime":2216.914,"body":"the neuroscience universe, where"},{"speaker":"Bruce Leuchter","startTime":2216.779,"endTime":2216.914,"body":"we're talking about"},{"speaker":"Bruce Leuchter","startTime":2216.914,"endTime":2217.011,"body":"neurodevelopmental diseases and"},{"speaker":"Bruce Leuchter","startTime":2216.914,"endTime":2217.011,"body":"developmental epileptic"},{"speaker":"Bruce Leuchter","startTime":2217.011,"endTime":2226.77,"body":"encephalopathies. Some of the"},{"speaker":"Bruce Leuchter","startTime":2217.011,"endTime":2226.77,"body":"therapeutic modalities that have"},{"speaker":"Bruce Leuchter","startTime":2226.83,"endTime":2230.37,"body":"come to the forefront over the"},{"speaker":"Bruce Leuchter","startTime":2226.83,"endTime":2230.37,"body":"last 5-10, years, gene"},{"speaker":"Bruce Leuchter","startTime":2230.37,"endTime":2234.33,"body":"therapies, oligonucleotide"},{"speaker":"Bruce Leuchter","startTime":2230.37,"endTime":2234.33,"body":"therapies, genetic medicines,"},{"speaker":"Bruce Leuchter","startTime":2234.93,"endTime":2239.19,"body":"are increasingly more often"},{"speaker":"Bruce Leuchter","startTime":2234.93,"endTime":2239.19,"body":"putting this on the radar screen"},{"speaker":"Bruce Leuchter","startTime":2239.37,"endTime":2242.955,"body":"of physicians, KOLs and"},{"speaker":"Bruce Leuchter","startTime":2239.37,"endTime":2242.955,"body":"companies, investors, for that"},{"speaker":"Bruce Leuchter","startTime":2242.955,"endTime":2246.495,"body":"matter, that you can actually"},{"speaker":"Bruce Leuchter","startTime":2242.955,"endTime":2246.495,"body":"take a rifle shot, as opposed to"},{"speaker":"Bruce Leuchter","startTime":2246.495,"endTime":2252.015,"body":"a buckshot, at these diseases."},{"speaker":"Bruce Leuchter","startTime":2246.495,"endTime":2252.015,"body":"But as I do think forward to"},{"speaker":"Bruce Leuchter","startTime":2252.135,"endTime":2256.995,"body":"delivering Phase 3 data in GRIN"},{"speaker":"Bruce Leuchter","startTime":2252.135,"endTime":2256.995,"body":"related NDD, and engaging with"},{"speaker":"Bruce Leuchter","startTime":2256.995,"endTime":2260.715,"body":"regulators around potential"},{"speaker":"Bruce Leuchter","startTime":2256.995,"endTime":2260.715,"body":"approval and the impact that it"},{"speaker":"Bruce Leuchter","startTime":2260.715,"endTime":2265.74,"body":"may have on patients, it's not"},{"speaker":"Bruce Leuchter","startTime":2260.715,"endTime":2265.74,"body":"just the impact that it can have"},{"speaker":"Bruce Leuchter","startTime":2265.74,"endTime":2270.24,"body":"on GRIN and its families. It's"},{"speaker":"Bruce Leuchter","startTime":2265.74,"endTime":2270.24,"body":"the impact that it can have for"},{"speaker":"Bruce Leuchter","startTime":2270.24,"endTime":2273.06,"body":"diseases that are also"},{"speaker":"Bruce Leuchter","startTime":2270.24,"endTime":2273.06,"body":"genetically defined. If we"},{"speaker":"Bruce Leuchter","startTime":2273.06,"endTime":2278.34,"body":"succeed in demonstrating that"},{"speaker":"Bruce Leuchter","startTime":2273.06,"endTime":2278.34,"body":"one can pursue underlying"},{"speaker":"Bruce Leuchter","startTime":2278.34,"endTime":2282.54,"body":"disease biology associated with"},{"speaker":"Bruce Leuchter","startTime":2278.34,"endTime":2282.54,"body":"these diseases, it gives hope,"},{"speaker":"Bruce Leuchter","startTime":2282.6,"endTime":2286.62,"body":"encouragement, motivation,"},{"speaker":"Bruce Leuchter","startTime":2282.6,"endTime":2286.62,"body":"energy, to doing the same thing"},{"speaker":"Bruce Leuchter","startTime":2286.62,"endTime":2289.725,"body":"across a number of different"},{"speaker":"Bruce Leuchter","startTime":2286.62,"endTime":2289.725,"body":"genetically defined diseases for"},{"speaker":"Bruce Leuchter","startTime":2289.725,"endTime":2292.545,"body":"which there is no therapeutic"},{"speaker":"Bruce Leuchter","startTime":2289.725,"endTime":2292.545,"body":"candidate in development, and"},{"speaker":"Bruce Leuchter","startTime":2292.545,"endTime":2295.365,"body":"for which there is no disease"},{"speaker":"Bruce Leuchter","startTime":2292.545,"endTime":2295.365,"body":"specific treatment, there is"},{"speaker":"Bruce Leuchter","startTime":2295.365,"endTime":2298.425,"body":"only an ability to treat"},{"speaker":"Bruce Leuchter","startTime":2295.365,"endTime":2298.425,"body":"symptoms. And part of what we're"},{"speaker":"Bruce Leuchter","startTime":2298.425,"endTime":2304.125,"body":"trying to talk to folks about,"},{"speaker":"Bruce Leuchter","startTime":2298.425,"endTime":2304.125,"body":"irrespective of constituency, is"},{"speaker":"Bruce Leuchter","startTime":2304.125,"endTime":2308.685,"body":"that creating disease specific"},{"speaker":"Bruce Leuchter","startTime":2304.125,"endTime":2308.685,"body":"treatments, creating treatments"},{"speaker":"Bruce Leuchter","startTime":2308.685,"endTime":2312.87,"body":"that go after the underlying"},{"speaker":"Bruce Leuchter","startTime":2308.685,"endTime":2312.87,"body":"disease process and target that"},{"speaker":"Bruce Leuchter","startTime":2312.87,"endTime":2316.11,"body":"biology, has to be the way in"},{"speaker":"Bruce Leuchter","startTime":2312.87,"endTime":2316.11,"body":"which we think about therapeutic"},{"speaker":"Bruce Leuchter","startTime":2316.17,"endTime":2318.63,"body":"development going forward,"},{"speaker":"Bruce Leuchter","startTime":2316.17,"endTime":2318.63,"body":"because it's got the greatest"},{"speaker":"Bruce Leuchter","startTime":2318.69,"endTime":2321.33,"body":"chance at delivering the most"},{"speaker":"Bruce Leuchter","startTime":2318.69,"endTime":2321.33,"body":"pronounced effect size and"},{"speaker":"Bruce Leuchter","startTime":2321.33,"endTime":2324.87,"body":"helping these patients"},{"speaker":"Bruce Leuchter","startTime":2321.33,"endTime":2324.87,"body":"maximally. I think if we spend"},{"speaker":"Bruce Leuchter","startTime":2325.29,"endTime":2329.55,"body":"our time, all of our time,"},{"speaker":"Bruce Leuchter","startTime":2325.29,"endTime":2329.55,"body":"continuing to pursue symptomatic"},{"speaker":"Bruce Leuchter","startTime":2329.55,"endTime":2332.49,"body":"treatments, we leave a lot on"},{"speaker":"Bruce Leuchter","startTime":2329.55,"endTime":2332.49,"body":"the table that these patients"},{"speaker":"Bruce Leuchter","startTime":2332.49,"endTime":2335.595,"body":"suffer from. And while we can"},{"speaker":"Bruce Leuchter","startTime":2332.49,"endTime":2335.595,"body":"see something like seizure, now"},{"speaker":"Bruce Leuchter","startTime":2335.595,"endTime":2339.075,"body":"you can actually see a patient"},{"speaker":"Bruce Leuchter","startTime":2335.595,"endTime":2339.075,"body":"have an epileptic seizure, what"},{"speaker":"Bruce Leuchter","startTime":2339.075,"endTime":2342.915,"body":"is harder to see is the impact"},{"speaker":"Bruce Leuchter","startTime":2339.075,"endTime":2342.915,"body":"of the non seizure symptoms on"},{"speaker":"Bruce Leuchter","startTime":2342.915,"endTime":2345.255,"body":"the patients, the families and"},{"speaker":"Bruce Leuchter","startTime":2342.915,"endTime":2345.255,"body":"the caregivers and the"},{"speaker":"Bruce Leuchter","startTime":2345.255,"endTime":2349.035,"body":"clinicians who treat them. By"},{"speaker":"Bruce Leuchter","startTime":2345.255,"endTime":2349.035,"body":"going after the broader disease"},{"speaker":"Bruce Leuchter","startTime":2349.035,"endTime":2352.275,"body":"state in the way that we are"},{"speaker":"Bruce Leuchter","startTime":2349.035,"endTime":2352.275,"body":"with radiprodil in GRIN NDD,"},{"speaker":"Bruce Leuchter","startTime":2352.695,"endTime":2355.215,"body":"we're giving these patients and"},{"speaker":"Bruce Leuchter","startTime":2352.695,"endTime":2355.215,"body":"all of the associated"},{"speaker":"Bruce Leuchter","startTime":2355.215,"endTime":2358.62,"body":"constituencies an opportunity to"},{"speaker":"Bruce Leuchter","startTime":2355.215,"endTime":2358.62,"body":"target the underlying disease"},{"speaker":"Bruce Leuchter","startTime":2358.62,"endTime":2363.24,"body":"biology. And that, I hope, is"},{"speaker":"Bruce Leuchter","startTime":2358.62,"endTime":2363.24,"body":"catalytic to additional work"},{"speaker":"Bruce Leuchter","startTime":2363.24,"endTime":2366.42,"body":"that can be done across"},{"speaker":"Bruce Leuchter","startTime":2363.24,"endTime":2366.42,"body":"additional diseases, where the"},{"speaker":"Bruce Leuchter","startTime":2366.42,"endTime":2369.96,"body":"bona fides are there. We've"},{"speaker":"Bruce Leuchter","startTime":2366.42,"endTime":2369.96,"body":"shown it can be done, and we get"},{"speaker":"Bruce Leuchter","startTime":2369.96,"endTime":2372.84,"body":"more momentum to treat these"},{"speaker":"Bruce Leuchter","startTime":2369.96,"endTime":2372.84,"body":"kids. When I was training in"},{"speaker":"Bruce Leuchter","startTime":2372.84,"endTime":2376.74,"body":"neurology, and I was looking, I"},{"speaker":"Bruce Leuchter","startTime":2372.84,"endTime":2376.74,"body":"was rotating through pediatric"},{"speaker":"Bruce Leuchter","startTime":2376.74,"endTime":2381.105,"body":"neurology clinics, cynically,"},{"speaker":"Bruce Leuchter","startTime":2376.74,"endTime":2381.105,"body":"very cynically, you found people"},{"speaker":"Bruce Leuchter","startTime":2381.105,"endTime":2384.405,"body":"saying, particularly those who"},{"speaker":"Bruce Leuchter","startTime":2381.105,"endTime":2384.405,"body":"weren't going into neurology,"},{"speaker":"Bruce Leuchter","startTime":2385.005,"endTime":2390.165,"body":"that neurology was a \"diagnose"},{"speaker":"Bruce Leuchter","startTime":2385.005,"endTime":2390.165,"body":"and adios\" subspecialty. You can"},{"speaker":"Bruce Leuchter","startTime":2390.225,"endTime":2393.525,"body":"make the diagnosis. It can be a"},{"speaker":"Bruce Leuchter","startTime":2390.225,"endTime":2393.525,"body":"very sophisticated diagnostic"},{"speaker":"Bruce Leuchter","startTime":2393.525,"endTime":2396.765,"body":"workup, and it can yield a lot"},{"speaker":"Bruce Leuchter","startTime":2393.525,"endTime":2396.765,"body":"of information. And then, in"},{"speaker":"Bruce Leuchter","startTime":2396.765,"endTime":2401.22,"body":"essence, you bid  adieu, adios"},{"speaker":"Bruce Leuchter","startTime":2396.765,"endTime":2401.22,"body":"to the patient., Because there"},{"speaker":"Bruce Leuchter","startTime":2401.22,"endTime":2403.65,"body":"just wasn't anything to treat"},{"speaker":"Bruce Leuchter","startTime":2401.22,"endTime":2403.65,"body":"them with, right? And we have"},{"speaker":"Bruce Leuchter","startTime":2403.71,"endTime":2407.55,"body":"most definitely made progress"},{"speaker":"Bruce Leuchter","startTime":2403.71,"endTime":2407.55,"body":"over the last 30 years in that"},{"speaker":"Bruce Leuchter","startTime":2407.55,"endTime":2410.49,"body":"regard. But I'd argue there's"},{"speaker":"Bruce Leuchter","startTime":2407.55,"endTime":2410.49,"body":"been an acceleration of that"},{"speaker":"Bruce Leuchter","startTime":2410.49,"endTime":2413.85,"body":"process over the course of the"},{"speaker":"Bruce Leuchter","startTime":2410.49,"endTime":2413.85,"body":"last five to 10 years where"},{"speaker":"Bruce Leuchter","startTime":2413.85,"endTime":2416.37,"body":"these sorts of disease specific"},{"speaker":"Bruce Leuchter","startTime":2413.85,"endTime":2416.37,"body":"treatments are now possible,"},{"speaker":"Bruce Leuchter","startTime":2416.49,"endTime":2420.93,"body":"such that no one contemplating a"},{"speaker":"Bruce Leuchter","startTime":2416.49,"endTime":2420.93,"body":"career in neurology has to ever"},{"speaker":"Bruce Leuchter","startTime":2420.93,"endTime":2425.175,"body":"hear \"diagnose and adios\" again,"},{"speaker":"Bruce Leuchter","startTime":2420.93,"endTime":2425.175,"body":"because it is not the way I"},{"speaker":"Bruce Leuchter","startTime":2425.175,"endTime":2428.295,"body":"think about neurology, and it's"},{"speaker":"Bruce Leuchter","startTime":2425.175,"endTime":2428.295,"body":"not the way we need to think"},{"speaker":"Bruce Leuchter","startTime":2428.295,"endTime":2431.535,"body":"about neurology today, given all"},{"speaker":"Bruce Leuchter","startTime":2428.295,"endTime":2431.535,"body":"the technological advancements."},{"speaker":"John Simboli","startTime":2432.135,"endTime":2434.235,"body":"Bruce, what's a"},{"speaker":"John Simboli","startTime":2432.135,"endTime":2434.235,"body":"good partner for Neurvati?"},{"speaker":"Bruce Leuchter","startTime":2434.66,"endTime":2437.42,"body":"It's a long"},{"speaker":"Bruce Leuchter","startTime":2434.66,"endTime":2437.42,"body":"list, John. There is no favored"},{"speaker":"Bruce Leuchter","startTime":2437.42,"endTime":2441.2,"body":"nation in our business. We are"},{"speaker":"Bruce Leuchter","startTime":2437.42,"endTime":2441.2,"body":"focused on the fundamentals"},{"speaker":"Bruce Leuchter","startTime":2441.26,"endTime":2444.68,"body":"associated with developing"},{"speaker":"Bruce Leuchter","startTime":2441.26,"endTime":2444.68,"body":"neurotherapeutics. That can"},{"speaker":"Bruce Leuchter","startTime":2444.68,"endTime":2447.92,"body":"happen in a number of different"},{"speaker":"Bruce Leuchter","startTime":2444.68,"endTime":2447.92,"body":"contexts. It is certainly true"},{"speaker":"Bruce Leuchter","startTime":2447.98,"endTime":2451.88,"body":"that large cap biopharmaceutical"},{"speaker":"Bruce Leuchter","startTime":2447.98,"endTime":2451.88,"body":"companies is where we spend a"},{"speaker":"Bruce Leuchter","startTime":2451.88,"endTime":2455.54,"body":"lot of time. That's where most"},{"speaker":"Bruce Leuchter","startTime":2451.88,"endTime":2455.54,"body":"of the portfolio reorganization"},{"speaker":"Bruce Leuchter","startTime":2455.6,"endTime":2459.26,"body":"and some of the strategic"},{"speaker":"Bruce Leuchter","startTime":2455.6,"endTime":2459.26,"body":"shifting occurs that enables"},{"speaker":"Bruce Leuchter","startTime":2459.425,"endTime":2462.965,"body":"opportunities for externalizing"},{"speaker":"Bruce Leuchter","startTime":2459.425,"endTime":2462.965,"body":"viable technologies. But it's"},{"speaker":"Bruce Leuchter","startTime":2462.965,"endTime":2466.385,"body":"also true that if you swung the"},{"speaker":"Bruce Leuchter","startTime":2462.965,"endTime":2466.385,"body":"pendulum to the other side,"},{"speaker":"Bruce Leuchter","startTime":2466.445,"endTime":2472.385,"body":"you'd find privately held or"},{"speaker":"Bruce Leuchter","startTime":2466.445,"endTime":2472.385,"body":"micro cap, small cap biopharma"},{"speaker":"Bruce Leuchter","startTime":2472.385,"endTime":2477.245,"body":"companies that may be challenged"},{"speaker":"Bruce Leuchter","startTime":2472.385,"endTime":2477.245,"body":"right now by the current market"},{"speaker":"Bruce Leuchter","startTime":2477.245,"endTime":2480.245,"body":"conditions, may not be able to"},{"speaker":"Bruce Leuchter","startTime":2477.245,"endTime":2480.245,"body":"finance all the work that they'd"},{"speaker":"Bruce Leuchter","startTime":2480.245,"endTime":2483.53,"body":"like to do, and may be under"},{"speaker":"Bruce Leuchter","startTime":2480.245,"endTime":2483.53,"body":"pressure to find solutions."},{"speaker":"Bruce Leuchter","startTime":2483.53,"endTime":2486.83,"body":"Their technologies may be"},{"speaker":"Bruce Leuchter","startTime":2483.53,"endTime":2486.83,"body":"equally as viable as the"},{"speaker":"Bruce Leuchter","startTime":2486.83,"endTime":2491.15,"body":"technologies of a multinational,"},{"speaker":"Bruce Leuchter","startTime":2486.83,"endTime":2491.15,"body":"large cap biopharma company. And"},{"speaker":"Bruce Leuchter","startTime":2491.57,"endTime":2493.61,"body":"then, of course, there's"},{"speaker":"Bruce Leuchter","startTime":2491.57,"endTime":2493.61,"body":"everyone in between. And"},{"speaker":"Bruce Leuchter","startTime":2494.03,"endTime":2497.81,"body":"everyone in between doesn't just"},{"speaker":"Bruce Leuchter","startTime":2494.03,"endTime":2497.81,"body":"include companies. There are"},{"speaker":"Bruce Leuchter","startTime":2498.47,"endTime":2501.53,"body":"investors in the world who've"},{"speaker":"Bruce Leuchter","startTime":2498.47,"endTime":2501.53,"body":"chosen to organize around"},{"speaker":"Bruce Leuchter","startTime":2501.65,"endTime":2505.775,"body":"neuroscience therapeutics and"},{"speaker":"Bruce Leuchter","startTime":2501.65,"endTime":2505.775,"body":"are looking for ways in which to"},{"speaker":"Bruce Leuchter","startTime":2505.775,"endTime":2509.555,"body":"collaborate, looking for ways to"},{"speaker":"Bruce Leuchter","startTime":2505.775,"endTime":2509.555,"body":"progress. There are programs"},{"speaker":"Bruce Leuchter","startTime":2509.555,"endTime":2513.095,"body":"that they've already gotten"},{"speaker":"Bruce Leuchter","startTime":2509.555,"endTime":2513.095,"body":"behind, but now need some help"},{"speaker":"Bruce Leuchter","startTime":2513.095,"endTime":2517.235,"body":"with. So we see our audience as"},{"speaker":"Bruce Leuchter","startTime":2513.095,"endTime":2517.235,"body":"a very broad audience. I would"},{"speaker":"Bruce Leuchter","startTime":2517.235,"endTime":2523.415,"body":"argue that you might include key"},{"speaker":"Bruce Leuchter","startTime":2517.235,"endTime":2523.415,"body":"opinion leaders and principal"},{"speaker":"Bruce Leuchter","startTime":2523.415,"endTime":2526.078,"body":"investigators in that audience."},{"speaker":"Bruce Leuchter","startTime":2523.415,"endTime":2526.078,"body":"We find ourselves in discussions"},{"speaker":"Bruce Leuchter","startTime":2526.078,"endTime":2527.54,"body":"with the world's leading"},{"speaker":"Bruce Leuchter","startTime":2526.078,"endTime":2527.54,"body":"scientists on some of the recent"},{"speaker":"Bruce Leuchter","startTime":2527.54,"endTime":2530.12,"body":"discoveries that they've made"},{"speaker":"Bruce Leuchter","startTime":2527.54,"endTime":2530.12,"body":"that can be mapped on to a"},{"speaker":"Bruce Leuchter","startTime":2530.12,"endTime":2533.66,"body":"clinical thesis surrounding a"},{"speaker":"Bruce Leuchter","startTime":2530.12,"endTime":2533.66,"body":"certain drug candidate. And that"},{"speaker":"Bruce Leuchter","startTime":2533.66,"endTime":2537.92,"body":"kind of innovation may not"},{"speaker":"Bruce Leuchter","startTime":2533.66,"endTime":2537.92,"body":"happen in a wet lab, for us, but"},{"speaker":"Bruce Leuchter","startTime":2538.04,"endTime":2540.56,"body":"certainly can leverage the work"},{"speaker":"Bruce Leuchter","startTime":2538.04,"endTime":2540.56,"body":"that does happen in wet labs,"},{"speaker":"Bruce Leuchter","startTime":2540.56,"endTime":2543.86,"body":"and for sure, manage, leverage"},{"speaker":"Bruce Leuchter","startTime":2540.56,"endTime":2543.86,"body":"rather, the work that these top"},{"speaker":"Bruce Leuchter","startTime":2543.86,"endTime":2547.58,"body":"tier thought leaders are willing"},{"speaker":"Bruce Leuchter","startTime":2543.86,"endTime":2547.58,"body":"to share with us. So we don't"},{"speaker":"Bruce Leuchter","startTime":2548.12,"endTime":2552.065,"body":"have a view that our model is"},{"speaker":"Bruce Leuchter","startTime":2548.12,"endTime":2552.065,"body":"appropriate for a small carve"},{"speaker":"Bruce Leuchter","startTime":2552.065,"endTime":2555.725,"body":"out of the industry. We have the"},{"speaker":"Bruce Leuchter","startTime":2552.065,"endTime":2555.725,"body":"view that neuroscience is"},{"speaker":"Bruce Leuchter","startTime":2555.725,"endTime":2559.685,"body":"critically important. It's"},{"speaker":"Bruce Leuchter","startTime":2555.725,"endTime":2559.685,"body":"important to our industry, but"},{"speaker":"Bruce Leuchter","startTime":2559.685,"endTime":2563.105,"body":"moreover, it's important to the"},{"speaker":"Bruce Leuchter","startTime":2559.685,"endTime":2563.105,"body":"world in which we live, where"},{"speaker":"Bruce Leuchter","startTime":2563.105,"endTime":2567.665,"body":"the unmet need is sky high, the"},{"speaker":"Bruce Leuchter","startTime":2563.105,"endTime":2567.665,"body":"viable technologies, while"},{"speaker":"Bruce Leuchter","startTime":2567.665,"endTime":2571.445,"body":"increasing in number, are still"},{"speaker":"Bruce Leuchter","startTime":2567.665,"endTime":2571.445,"body":"not enough. We see the universe"},{"speaker":"Bruce Leuchter","startTime":2571.445,"endTime":2574.37,"body":"is big, and we see it with a lot"},{"speaker":"Bruce Leuchter","startTime":2571.445,"endTime":2574.37,"body":"of opportunity, and we think"},{"speaker":"Bruce Leuchter","startTime":2574.37,"endTime":2578.33,"body":"we've got the right team"},{"speaker":"Bruce Leuchter","startTime":2574.37,"endTime":2578.33,"body":"members, the right supporters,"},{"speaker":"Bruce Leuchter","startTime":2578.33,"endTime":2581.75,"body":"the right advisors to help us"},{"speaker":"Bruce Leuchter","startTime":2578.33,"endTime":2581.75,"body":"succeed in the long term."},{"speaker":"John Simboli","startTime":2581.75,"endTime":2584.57,"body":"Thanks for"},{"speaker":"John Simboli","startTime":2581.75,"endTime":2584.57,"body":"speaking with me today, Bruce."},{"speaker":"Bruce Leuchter","startTime":2584.87,"endTime":2586.85,"body":"Thank you, John,"},{"speaker":"Bruce Leuchter","startTime":2584.87,"endTime":2586.85,"body":"it was a pleasure, and I enjoyed"},{"speaker":"Bruce Leuchter","startTime":2586.85,"endTime":2589.79,"body":"the conversation. Lots of"},{"speaker":"Bruce Leuchter","startTime":2586.85,"endTime":2589.79,"body":"important topics to discuss, and"},{"speaker":"Bruce Leuchter","startTime":2589.79,"endTime":2591.47,"body":"I'm glad we hit on a number of"},{"speaker":"Bruce Leuchter","startTime":2589.79,"endTime":2591.47,"body":"them."}]}