{"version":"1.0.0","segments":[{"speaker":"Lance Baldo","startTime":6.39,"endTime":20.52,"body":"I had worked in"},{"speaker":"Lance Baldo","startTime":6.39,"endTime":20.52,"body":"both small and large pharma, and"},{"speaker":"Lance Baldo","startTime":20.52,"endTime":22.95,"body":"really had thought that my"},{"speaker":"Lance Baldo","startTime":20.52,"endTime":22.95,"body":"career was going to end in large"},{"speaker":"Lance Baldo","startTime":23.82,"endTime":50.1,"body":"pharma, hopefully in a senior"},{"speaker":"Lance Baldo","startTime":23.82,"endTime":50.1,"body":"leadership type role. And then I"},{"speaker":"Lance Baldo","startTime":50.1,"endTime":54.06,"body":"got drawn away for a couple of"},{"speaker":"Lance Baldo","startTime":50.1,"endTime":54.06,"body":"biotechs, but in that case, it"},{"speaker":"Lance Baldo","startTime":54.06,"endTime":58.02,"body":"was as a chief medical officer,"},{"speaker":"Lance Baldo","startTime":54.06,"endTime":58.02,"body":"a CMO. But I still aspired to"},{"speaker":"Lance Baldo","startTime":58.02,"endTime":62.34,"body":"that kind of senior leadership"},{"speaker":"Lance Baldo","startTime":58.02,"endTime":62.34,"body":"position, and really at some"},{"speaker":"Lance Baldo","startTime":62.34,"endTime":64.32,"body":"point, as you start getting a"},{"speaker":"Lance Baldo","startTime":62.34,"endTime":64.32,"body":"little bit older and a little"},{"speaker":"Lance Baldo","startTime":64.32,"endTime":67.98,"body":"bit wiser, I said, I think now"},{"speaker":"Lance Baldo","startTime":64.32,"endTime":67.98,"body":"is the time to do this. And I"},{"speaker":"Lance Baldo","startTime":67.98,"endTime":71.61,"body":"guess I was fortunate in that I"},{"speaker":"Lance Baldo","startTime":67.98,"endTime":71.61,"body":"could be kind of more narrowly"},{"speaker":"Lance Baldo","startTime":71.61,"endTime":74.67,"body":"focused, and I decided that I"},{"speaker":"Lance Baldo","startTime":71.61,"endTime":74.67,"body":"wanted it to be an opportunity"},{"speaker":"Lance Baldo","startTime":74.67,"endTime":77.43,"body":"in ophthalmology because I"},{"speaker":"Lance Baldo","startTime":74.67,"endTime":77.43,"body":"really loved retina and I really"},{"speaker":"Lance Baldo","startTime":77.43,"endTime":81.33,"body":"loved ophthalmology, and so I"},{"speaker":"Lance Baldo","startTime":77.43,"endTime":81.33,"body":"started looking exclusively in"},{"speaker":"Lance Baldo","startTime":81.33,"endTime":81.96,"body":"ophthalmology.."},{"speaker":"John Simboli","startTime":83.01,"endTime":87.39,"body":"You're trained as"},{"speaker":"John Simboli","startTime":83.01,"endTime":87.39,"body":"a physician, and like many CEOs"},{"speaker":"John Simboli","startTime":87.39,"endTime":91.74,"body":"I've worked with, that that is a"},{"speaker":"John Simboli","startTime":87.39,"endTime":91.74,"body":"path. What told you that this"},{"speaker":"John Simboli","startTime":91.74,"endTime":94.17,"body":"branch was the one you want to"},{"speaker":"John Simboli","startTime":91.74,"endTime":94.17,"body":"take, as opposed to that one?"},{"speaker":"Lance Baldo","startTime":94.62,"endTime":97.26,"body":"Early in my career,"},{"speaker":"Lance Baldo","startTime":94.62,"endTime":97.26,"body":"John, people would ask me, like,"},{"speaker":"Lance Baldo","startTime":97.29,"endTime":99.96,"body":"\"Do you feel like you're wasting"},{"speaker":"Lance Baldo","startTime":97.29,"endTime":99.96,"body":"your medical doctorate? Are you"},{"speaker":"Lance Baldo","startTime":99.96,"endTime":102.75,"body":"wasting your medical degree?"},{"speaker":"Lance Baldo","startTime":99.96,"endTime":102.75,"body":"And that question used to give"},{"speaker":"Lance Baldo","startTime":102.75,"endTime":106.17,"body":"me some pause for a moment. But"},{"speaker":"Lance Baldo","startTime":102.75,"endTime":106.17,"body":"now I recognize that while I"},{"speaker":"Lance Baldo","startTime":106.17,"endTime":109.89,"body":"don't use my medical degree the"},{"speaker":"Lance Baldo","startTime":106.17,"endTime":109.89,"body":"way many clinicians do, or the"},{"speaker":"Lance Baldo","startTime":109.89,"endTime":113.52,"body":"way I would have in the past, I"},{"speaker":"Lance Baldo","startTime":109.89,"endTime":113.52,"body":"still use that education. I"},{"speaker":"Lance Baldo","startTime":113.52,"endTime":116.22,"body":"still use that lexicon, John."},{"speaker":"Lance Baldo","startTime":113.52,"endTime":116.22,"body":"When you go through medical"},{"speaker":"Lance Baldo","startTime":116.22,"endTime":118.92,"body":"training, you learn a whole new"},{"speaker":"Lance Baldo","startTime":116.22,"endTime":118.92,"body":"way of thinking and a whole new"},{"speaker":"Lance Baldo","startTime":118.92,"endTime":122.16,"body":"way of talking, and I do apply"},{"speaker":"Lance Baldo","startTime":118.92,"endTime":122.16,"body":"that to the job I have today. It"},{"speaker":"Lance Baldo","startTime":122.16,"endTime":127.02,"body":"also gives me an extra, I'd like"},{"speaker":"Lance Baldo","startTime":122.16,"endTime":127.02,"body":"to say more than an extra, but"},{"speaker":"Lance Baldo","startTime":127.02,"endTime":130.2,"body":"certainly an air of credibility"},{"speaker":"Lance Baldo","startTime":127.02,"endTime":130.2,"body":"when you're out there talking to"},{"speaker":"Lance Baldo","startTime":130.2,"endTime":132.81,"body":"physician customers. When you're"},{"speaker":"Lance Baldo","startTime":130.2,"endTime":132.81,"body":"out there, sometimes even in"},{"speaker":"Lance Baldo","startTime":132.81,"endTime":136.83,"body":"front of patients, and so I"},{"speaker":"Lance Baldo","startTime":132.81,"endTime":136.83,"body":"still enjoy that part of my job."},{"speaker":"Lance Baldo","startTime":136.86,"endTime":140.31,"body":"We're fortunate that at Beacon"},{"speaker":"Lance Baldo","startTime":136.86,"endTime":140.31,"body":"we work in rare diseases, and"},{"speaker":"Lance Baldo","startTime":140.31,"endTime":143.61,"body":"that the patient community has a"},{"speaker":"Lance Baldo","startTime":140.31,"endTime":143.61,"body":"really strong voice, and so I'm"},{"speaker":"Lance Baldo","startTime":143.61,"endTime":147.96,"body":"able to go out there as not only"},{"speaker":"Lance Baldo","startTime":143.61,"endTime":147.96,"body":"a CEO but also a clinician and"},{"speaker":"Lance Baldo","startTime":147.96,"endTime":151.44,"body":"hear from these patients and"},{"speaker":"Lance Baldo","startTime":147.96,"endTime":151.44,"body":"their families about the impact"},{"speaker":"Lance Baldo","startTime":151.44,"endTime":154.17,"body":"that some of these devastating"},{"speaker":"Lance Baldo","startTime":151.44,"endTime":154.17,"body":"blindness diseases could have,"},{"speaker":"Lance Baldo","startTime":154.17,"endTime":157.65,"body":"and that all, you know, hearkens"},{"speaker":"Lance Baldo","startTime":154.17,"endTime":157.65,"body":"back to my medical training. And"},{"speaker":"Lance Baldo","startTime":157.65,"endTime":160.17,"body":"and it really is one of the"},{"speaker":"Lance Baldo","startTime":157.65,"endTime":160.17,"body":"reasons why I have so much"},{"speaker":"Lance Baldo","startTime":160.17,"endTime":162.09,"body":"passion for what I'm doing and"},{"speaker":"Lance Baldo","startTime":160.17,"endTime":162.09,"body":"what we're doing here at"},{"speaker":"Lance Baldo","startTime":162.09,"endTime":162.69,"body":"Beacon.."},{"speaker":"John Simboli","startTime":162.78,"endTime":165.24,"body":"So when you decide"},{"speaker":"John Simboli","startTime":162.78,"endTime":165.24,"body":"that you wanted to become a CEO"},{"speaker":"John Simboli","startTime":165.24,"endTime":170.19,"body":"and lead a biopharma company,"},{"speaker":"John Simboli","startTime":165.24,"endTime":170.19,"body":"it's weighty decision. How do"},{"speaker":"John Simboli","startTime":170.19,"endTime":172.44,"body":"you go back to your family and"},{"speaker":"John Simboli","startTime":170.19,"endTime":172.44,"body":"explain that?"},{"speaker":"Lance Baldo","startTime":173.1,"endTime":175.98,"body":"The hardest"},{"speaker":"Lance Baldo","startTime":173.1,"endTime":175.98,"body":"conversation I had to have was"},{"speaker":"Lance Baldo","startTime":175.98,"endTime":178.65,"body":"almost certainly telling, and"},{"speaker":"Lance Baldo","startTime":175.98,"endTime":178.65,"body":"particularly, my mother. I come"},{"speaker":"Lance Baldo","startTime":178.65,"endTime":181.59,"body":"from an Italian American"},{"speaker":"Lance Baldo","startTime":178.65,"endTime":181.59,"body":"upbringing, and like, you know"},{"speaker":"Lance Baldo","startTime":181.62,"endTime":184.83,"body":"your mother and your life, and"},{"speaker":"Lance Baldo","startTime":181.62,"endTime":184.83,"body":"it was easier to tell the"},{"speaker":"Lance Baldo","startTime":184.83,"endTime":187.71,"body":"chairman of my department that I"},{"speaker":"Lance Baldo","startTime":184.83,"endTime":187.71,"body":"was leaving surgery than it was"},{"speaker":"Lance Baldo","startTime":187.71,"endTime":190.14,"body":"to tell my mother. And a little"},{"speaker":"Lance Baldo","startTime":187.71,"endTime":190.14,"body":"part of it, she said to me, I"},{"speaker":"Lance Baldo","startTime":190.14,"endTime":192.33,"body":"remember this was like many"},{"speaker":"Lance Baldo","startTime":190.14,"endTime":192.33,"body":"months later, maybe even many"},{"speaker":"Lance Baldo","startTime":192.33,"endTime":195.9,"body":"years later. She said, \"It used"},{"speaker":"Lance Baldo","startTime":192.33,"endTime":195.9,"body":"to be really easy for me to tell"},{"speaker":"Lance Baldo","startTime":195.9,"endTime":199.47,"body":"people what you did. My son is a"},{"speaker":"Lance Baldo","startTime":195.9,"endTime":199.47,"body":"doctor. My son is a surgeon. I"},{"speaker":"Lance Baldo","startTime":199.47,"endTime":202.17,"body":"think to this day, John, like"},{"speaker":"Lance Baldo","startTime":199.47,"endTime":202.17,"body":"to, you know, this is like 25"},{"speaker":"Lance Baldo","startTime":202.17,"endTime":205.17,"body":"years later. She's still not"},{"speaker":"Lance Baldo","startTime":202.17,"endTime":205.17,"body":"quite certain what I do for a"},{"speaker":"Lance Baldo","startTime":205.17,"endTime":207.24,"body":"living because it's a lot harder"},{"speaker":"Lance Baldo","startTime":205.17,"endTime":207.24,"body":"to explain. Like, what do you"},{"speaker":"Lance Baldo","startTime":207.24,"endTime":210.18,"body":"actually do as a CEO or what do"},{"speaker":"Lance Baldo","startTime":207.24,"endTime":210.18,"body":"you actually do as a leader in"},{"speaker":"Lance Baldo","startTime":210.18,"endTime":213.06,"body":"biotechnology? No, but I'll"},{"speaker":"Lance Baldo","startTime":210.18,"endTime":213.06,"body":"never forget that day. It was,"},{"speaker":"Lance Baldo","startTime":213.06,"endTime":215.49,"body":"you know, pre Zoom and it wasn't"},{"speaker":"Lance Baldo","startTime":213.06,"endTime":215.49,"body":"face to face and it was over the"},{"speaker":"Lance Baldo","startTime":215.49,"endTime":217.98,"body":"phone, and I had to call my"},{"speaker":"Lance Baldo","startTime":215.49,"endTime":217.98,"body":"mother and tell her I was"},{"speaker":"Lance Baldo","startTime":217.98,"endTime":220.29,"body":"leaving. And the other thing is,"},{"speaker":"Lance Baldo","startTime":217.98,"endTime":220.29,"body":"John, they were so invested in"},{"speaker":"Lance Baldo","startTime":220.29,"endTime":223.62,"body":"me. I mean, I couldn't be where"},{"speaker":"Lance Baldo","startTime":220.29,"endTime":223.62,"body":"I am today if it wasn't for the"},{"speaker":"Lance Baldo","startTime":223.62,"endTime":226.5,"body":"loving support of my parents and"},{"speaker":"Lance Baldo","startTime":223.62,"endTime":226.5,"body":"the economic support of my"},{"speaker":"Lance Baldo","startTime":226.5,"endTime":230.31,"body":"parents. Right? It is not cheap"},{"speaker":"Lance Baldo","startTime":226.5,"endTime":230.31,"body":"to become a physician, and so"},{"speaker":"Lance Baldo","startTime":230.34,"endTime":233.64,"body":"I'm still appreciative to this"},{"speaker":"Lance Baldo","startTime":230.34,"endTime":233.64,"body":"day of all the support that they"},{"speaker":"Lance Baldo","startTime":233.64,"endTime":236.85,"body":"gave me emotionally and"},{"speaker":"Lance Baldo","startTime":233.64,"endTime":236.85,"body":"financially for me to get that"},{"speaker":"Lance Baldo","startTime":236.85,"endTime":240.24,"body":"amazing education, which now I"},{"speaker":"Lance Baldo","startTime":236.85,"endTime":240.24,"body":"get to apply to medicine a very"},{"speaker":"Lance Baldo","startTime":240.24,"endTime":240.9,"body":"different way."},{"speaker":"Lance Baldo","startTime":241.32,"endTime":246.06,"body":"The harder transition for me was"},{"speaker":"Lance Baldo","startTime":241.32,"endTime":246.06,"body":"moving from a big company. I"},{"speaker":"Lance Baldo","startTime":246.06,"endTime":249.45,"body":"went rom Roche Genentech, to a"},{"speaker":"Lance Baldo","startTime":246.06,"endTime":249.45,"body":"small company and becoming a CMO"},{"speaker":"Lance Baldo","startTime":249.45,"endTime":252.0,"body":"for the first time. That was the"},{"speaker":"Lance Baldo","startTime":249.45,"endTime":252.0,"body":"harder transition for me. I"},{"speaker":"Lance Baldo","startTime":252.0,"endTime":255.27,"body":"actually feel like there's more"},{"speaker":"Lance Baldo","startTime":252.0,"endTime":255.27,"body":"parallels to being a small or"},{"speaker":"Lance Baldo","startTime":255.27,"endTime":257.7,"body":"mid-sized company CMO and"},{"speaker":"Lance Baldo","startTime":255.27,"endTime":257.7,"body":"actually being a smaller"},{"speaker":"Lance Baldo","startTime":257.7,"endTime":261.27,"body":"mid-sized company CEO. I was"},{"speaker":"Lance Baldo","startTime":257.7,"endTime":261.27,"body":"maybe maybe fortunate, although"},{"speaker":"Lance Baldo","startTime":261.27,"endTime":263.49,"body":"some would say this is"},{"speaker":"Lance Baldo","startTime":261.27,"endTime":263.49,"body":"unfortunate. When I joined as"},{"speaker":"Lance Baldo","startTime":263.49,"endTime":267.21,"body":"the CEO of Beacon, we were"},{"speaker":"Lance Baldo","startTime":263.49,"endTime":267.21,"body":"absent a CMO, so I like to say I"},{"speaker":"Lance Baldo","startTime":267.21,"endTime":270.48,"body":"was pulling double duty for some"},{"speaker":"Lance Baldo","startTime":267.21,"endTime":270.48,"body":"period of time. And obviously,"},{"speaker":"Lance Baldo","startTime":270.51,"endTime":273.27,"body":"well, maybe not obviously, but"},{"speaker":"Lance Baldo","startTime":270.51,"endTime":273.27,"body":"the comfort level was a lot more"},{"speaker":"Lance Baldo","startTime":273.93,"endTime":277.23,"body":"being the CMO, the CMO part of"},{"speaker":"Lance Baldo","startTime":273.93,"endTime":277.23,"body":"the job, and less so on the CEO"},{"speaker":"Lance Baldo","startTime":277.23,"endTime":279.51,"body":"part of the job. But it did"},{"speaker":"Lance Baldo","startTime":277.23,"endTime":279.51,"body":"allow me to really dig into the"},{"speaker":"Lance Baldo","startTime":279.51,"endTime":282.81,"body":"business and really get to know"},{"speaker":"Lance Baldo","startTime":279.51,"endTime":282.81,"body":"a lot more of the company"},{"speaker":"Lance Baldo","startTime":282.81,"endTime":285.39,"body":"because I had to kind of pull"},{"speaker":"Lance Baldo","startTime":282.81,"endTime":285.39,"body":"this double duty for really"},{"speaker":"Lance Baldo","startTime":285.39,"endTime":288.03,"body":"about nine months until we were"},{"speaker":"Lance Baldo","startTime":285.39,"endTime":288.03,"body":"able to hire an absolutely"},{"speaker":"Lance Baldo","startTime":288.03,"endTime":290.49,"body":"excellent chief medical officer"},{"speaker":"Lance Baldo","startTime":288.03,"endTime":290.49,"body":"that we have right now."},{"speaker":"John Simboli","startTime":291.18,"endTime":294.0,"body":"Each of us, when"},{"speaker":"John Simboli","startTime":291.18,"endTime":294.0,"body":"we try when we have new"},{"speaker":"John Simboli","startTime":294.0,"endTime":296.82,"body":"opportunities, we try to picture"},{"speaker":"John Simboli","startTime":294.0,"endTime":296.82,"body":"what it's going to be like, and"},{"speaker":"John Simboli","startTime":296.82,"endTime":299.88,"body":"some of it is what we picture,"},{"speaker":"John Simboli","startTime":296.82,"endTime":299.88,"body":"and some of it is not. So what?"},{"speaker":"John Simboli","startTime":299.88,"endTime":302.64,"body":"Was what you were able to"},{"speaker":"John Simboli","startTime":299.88,"endTime":302.64,"body":"anticipate and what was not for"},{"speaker":"John Simboli","startTime":302.64,"endTime":303.3,"body":"those roles."},{"speaker":"Lance Baldo","startTime":303.57,"endTime":305.4,"body":"When I was at"},{"speaker":"Lance Baldo","startTime":303.57,"endTime":305.4,"body":"Genentech, I had become quite"},{"speaker":"Lance Baldo","startTime":305.4,"endTime":308.49,"body":"senior, and I had about about"},{"speaker":"Lance Baldo","startTime":305.4,"endTime":308.49,"body":"700 people in my organization."},{"speaker":"Lance Baldo","startTime":308.49,"endTime":312.33,"body":"And so, my job was truly to kind"},{"speaker":"Lance Baldo","startTime":308.49,"endTime":312.33,"body":"of communicate and lead, and"},{"speaker":"Lance Baldo","startTime":312.33,"endTime":315.03,"body":"hopefully guide people to make"},{"speaker":"Lance Baldo","startTime":312.33,"endTime":315.03,"body":"good decisions. Again, you"},{"speaker":"Lance Baldo","startTime":315.03,"endTime":317.58,"body":"didn't do too much because you"},{"speaker":"Lance Baldo","startTime":315.03,"endTime":317.58,"body":"get to that level, and you're"},{"speaker":"Lance Baldo","startTime":317.61,"endTime":320.22,"body":"hopefully guiding and providing"},{"speaker":"Lance Baldo","startTime":317.61,"endTime":320.22,"body":"some guardrails for people to"},{"speaker":"Lance Baldo","startTime":320.22,"endTime":324.63,"body":"get on and do great work, then I"},{"speaker":"Lance Baldo","startTime":320.22,"endTime":324.63,"body":"jumped to a relatively small"},{"speaker":"Lance Baldo","startTime":324.66,"endTime":328.89,"body":"biotech company as a CMO, and it"},{"speaker":"Lance Baldo","startTime":324.66,"endTime":328.89,"body":"was in a new area for me. And"},{"speaker":"Lance Baldo","startTime":328.89,"endTime":332.04,"body":"like the third week on the job,"},{"speaker":"Lance Baldo","startTime":328.89,"endTime":332.04,"body":"we had to present something to"},{"speaker":"Lance Baldo","startTime":332.04,"endTime":334.32,"body":"the FDA. And so I remember, I"},{"speaker":"Lance Baldo","startTime":332.04,"endTime":334.32,"body":"asked the question. I was like,"},{"speaker":"Lance Baldo","startTime":334.38,"endTime":337.11,"body":"\"Great, who's presenting to the"},{"speaker":"Lance Baldo","startTime":334.38,"endTime":337.11,"body":"FDA? And they looked at me, and"},{"speaker":"Lance Baldo","startTime":337.11,"endTime":339.6,"body":"you know where this is going."},{"speaker":"Lance Baldo","startTime":337.11,"endTime":339.6,"body":"And they said, \"You.\" And I was"},{"speaker":"Lance Baldo","startTime":339.6,"endTime":342.87,"body":"like, \"Okay,\" I said, \"Well,"},{"speaker":"Lance Baldo","startTime":339.6,"endTime":342.87,"body":"where's the content? Where are"},{"speaker":"Lance Baldo","startTime":342.87,"endTime":345.66,"body":"the slides?\" They're like,"},{"speaker":"Lance Baldo","startTime":342.87,"endTime":345.66,"body":"\"Lance, you need to pull"},{"speaker":"Lance Baldo","startTime":345.66,"endTime":350.73,"body":"together the slides,\" and I was"},{"speaker":"Lance Baldo","startTime":345.66,"endTime":350.73,"body":"like, wow, you know, I, and I."},{"speaker":"Lance Baldo","startTime":350.76,"endTime":353.4,"body":"It's not that I couldn't do it,"},{"speaker":"Lance Baldo","startTime":350.76,"endTime":353.4,"body":"but again, it's using muscles I"},{"speaker":"Lance Baldo","startTime":353.4,"endTime":355.83,"body":"hadn't used before. And I"},{"speaker":"Lance Baldo","startTime":353.4,"endTime":355.83,"body":"remember, and I worked with a"},{"speaker":"Lance Baldo","startTime":355.83,"endTime":357.84,"body":"couple people on the team, and"},{"speaker":"Lance Baldo","startTime":355.83,"endTime":357.84,"body":"we put together these great"},{"speaker":"Lance Baldo","startTime":357.84,"endTime":362.16,"body":"slides. And for the first time"},{"speaker":"Lance Baldo","startTime":357.84,"endTime":362.16,"body":"in probably half a decade of my"},{"speaker":"Lance Baldo","startTime":362.16,"endTime":365.61,"body":"career, I actually scripted."},{"speaker":"Lance Baldo","startTime":362.16,"endTime":365.61,"body":"This was pre-Zoom, so it was a"},{"speaker":"Lance Baldo","startTime":365.61,"endTime":369.18,"body":"teleconference. I scripted"},{"speaker":"Lance Baldo","startTime":365.61,"endTime":369.18,"body":"almost the entire presentation I"},{"speaker":"Lance Baldo","startTime":369.18,"endTime":371.82,"body":"was going to give because it was"},{"speaker":"Lance Baldo","startTime":369.18,"endTime":371.82,"body":"just outside of my level of"},{"speaker":"Lance Baldo","startTime":371.82,"endTime":375.99,"body":"comfort. And I remember after"},{"speaker":"Lance Baldo","startTime":371.82,"endTime":375.99,"body":"that after that call, John, that"},{"speaker":"Lance Baldo","startTime":375.99,"endTime":378.63,"body":"evening chatted with my wife,"},{"speaker":"Lance Baldo","startTime":375.99,"endTime":378.63,"body":"and I said, \"You know, I think"},{"speaker":"Lance Baldo","startTime":378.66,"endTime":381.66,"body":"I'm in over my head. Like I"},{"speaker":"Lance Baldo","startTime":378.66,"endTime":381.66,"body":"think this is going to be the"},{"speaker":"Lance Baldo","startTime":381.66,"endTime":384.66,"body":"first time in my career where"},{"speaker":"Lance Baldo","startTime":381.66,"endTime":384.66,"body":"I'm going to fail.\" Now fast"},{"speaker":"Lance Baldo","startTime":384.66,"endTime":386.88,"body":"forward six months later, and"},{"speaker":"Lance Baldo","startTime":384.66,"endTime":386.88,"body":"you get your legs under you, and"},{"speaker":"Lance Baldo","startTime":386.88,"endTime":390.09,"body":"everything goes very well. But I"},{"speaker":"Lance Baldo","startTime":386.88,"endTime":390.09,"body":"remember that that third week on"},{"speaker":"Lance Baldo","startTime":390.09,"endTime":392.85,"body":"the job, I thought, wow, now"},{"speaker":"Lance Baldo","startTime":390.09,"endTime":392.85,"body":"you've done it, Lance. You've"},{"speaker":"Lance Baldo","startTime":392.85,"endTime":397.26,"body":"really put yourself in over your"},{"speaker":"Lance Baldo","startTime":392.85,"endTime":397.26,"body":"over your head. But it was a"},{"speaker":"Lance Baldo","startTime":397.26,"endTime":400.32,"body":"great experience. I had a really"},{"speaker":"Lance Baldo","startTime":397.26,"endTime":400.32,"body":"nurturing group of managers and"},{"speaker":"Lance Baldo","startTime":400.32,"endTime":404.16,"body":"a CEO over there as well, and it"},{"speaker":"Lance Baldo","startTime":400.32,"endTime":404.16,"body":"was a really great experience"},{"speaker":"Lance Baldo","startTime":404.16,"endTime":406.8,"body":"for me. But it could be hard."},{"speaker":"Lance Baldo","startTime":404.16,"endTime":406.8,"body":"That first transition, I tell"},{"speaker":"Lance Baldo","startTime":406.8,"endTime":410.46,"body":"people from big company to like"},{"speaker":"Lance Baldo","startTime":406.8,"endTime":410.46,"body":"small company, that could be a"},{"speaker":"Lance Baldo","startTime":410.46,"endTime":411.39,"body":"hard transition."},{"speaker":"John Simboli","startTime":411.72,"endTime":414.39,"body":"A lot of people"},{"speaker":"John Simboli","startTime":411.72,"endTime":414.39,"body":"would gravitate towards the the"},{"speaker":"John Simboli","startTime":414.39,"endTime":418.53,"body":"surer thing, the comfort zone."},{"speaker":"John Simboli","startTime":414.39,"endTime":418.53,"body":"Some people, for whatever"},{"speaker":"John Simboli","startTime":418.53,"endTime":421.89,"body":"reason, go the other direction."},{"speaker":"John Simboli","startTime":418.53,"endTime":421.89,"body":"So, what was pulling you to try"},{"speaker":"John Simboli","startTime":422.13,"endTime":423.3,"body":"to go someplace new?"},{"speaker":"Lance Baldo","startTime":423.81,"endTime":426.66,"body":"I kind of had this"},{"speaker":"Lance Baldo","startTime":423.81,"endTime":426.66,"body":"epiphany that, like, you need to"},{"speaker":"Lance Baldo","startTime":426.66,"endTime":429.57,"body":"sometimes get outside your"},{"speaker":"Lance Baldo","startTime":426.66,"endTime":429.57,"body":"comfort zone, and so I just"},{"speaker":"Lance Baldo","startTime":429.57,"endTime":432.75,"body":"thought to myself, if I don't"},{"speaker":"Lance Baldo","startTime":429.57,"endTime":432.75,"body":"get outside my comfort zone, I"},{"speaker":"Lance Baldo","startTime":432.75,"endTime":435.81,"body":"may. And I tried to live my life"},{"speaker":"Lance Baldo","startTime":432.75,"endTime":435.81,"body":"with very few, if any, regrets,"},{"speaker":"Lance Baldo","startTime":435.81,"endTime":438.24,"body":"but I may regret that. And so I"},{"speaker":"Lance Baldo","startTime":435.81,"endTime":438.24,"body":"decided to kind of get outside"},{"speaker":"Lance Baldo","startTime":438.24,"endTime":442.05,"body":"my comfort zone, and a lot like"},{"speaker":"Lance Baldo","startTime":438.24,"endTime":442.05,"body":"leaving clinical medicine, it"},{"speaker":"Lance Baldo","startTime":442.05,"endTime":446.94,"body":"sure feels scary at the"},{"speaker":"Lance Baldo","startTime":442.05,"endTime":446.94,"body":"beginning. But often you look"},{"speaker":"Lance Baldo","startTime":446.94,"endTime":450.39,"body":"back, sometimes months and often"},{"speaker":"Lance Baldo","startTime":446.94,"endTime":450.39,"body":"years later, and you think,"},{"speaker":"Lance Baldo","startTime":450.72,"endTime":452.37,"body":"\"Hey, that was the right"},{"speaker":"Lance Baldo","startTime":450.72,"endTime":452.37,"body":"decision. That was the right"},{"speaker":"Lance Baldo","startTime":452.37,"endTime":455.49,"body":"decision to make.\" And I often"},{"speaker":"Lance Baldo","startTime":452.37,"endTime":455.49,"body":"think about. I had a really"},{"speaker":"Lance Baldo","startTime":455.49,"endTime":461.58,"body":"great mentor, Clive Meanwell,"},{"speaker":"Lance Baldo","startTime":455.49,"endTime":461.58,"body":"who is quite quite well known"},{"speaker":"Lance Baldo","startTime":461.58,"endTime":464.52,"body":"now, particularly he was the CEO"},{"speaker":"Lance Baldo","startTime":461.58,"endTime":464.52,"body":"and founder of The Medicines"},{"speaker":"Lance Baldo","startTime":464.52,"endTime":468.03,"body":"Company, and then later,"},{"speaker":"Lance Baldo","startTime":464.52,"endTime":468.03,"body":"Metsera. But he talked about"},{"speaker":"Lance Baldo","startTime":468.03,"endTime":470.64,"body":"something called lifetime"},{"speaker":"Lance Baldo","startTime":468.03,"endTime":470.64,"body":"impact, as well. And he kind of,"},{"speaker":"Lance Baldo","startTime":470.94,"endTime":473.34,"body":"you know, when I had left"},{"speaker":"Lance Baldo","startTime":470.94,"endTime":473.34,"body":"clinical medicine, and I kind of"},{"speaker":"Lance Baldo","startTime":473.34,"endTime":475.59,"body":"was regretting like, hey, I'm"},{"speaker":"Lance Baldo","startTime":473.34,"endTime":475.59,"body":"not going to be helping patients"},{"speaker":"Lance Baldo","startTime":475.59,"endTime":478.44,"body":"as much anymore. And he said,"},{"speaker":"Lance Baldo","startTime":475.59,"endTime":478.44,"body":"\"Well, think about.\" He goes,"},{"speaker":"Lance Baldo","startTime":478.5,"endTime":481.38,"body":"\"You may not help patients as"},{"speaker":"Lance Baldo","startTime":478.5,"endTime":481.38,"body":"much, but think about how many"},{"speaker":"Lance Baldo","startTime":481.38,"endTime":484.02,"body":"tens of thousands, or even"},{"speaker":"Lance Baldo","startTime":481.38,"endTime":484.02,"body":"millions of patients, you could"},{"speaker":"Lance Baldo","startTime":484.02,"endTime":487.29,"body":"actually impact if you have a"},{"speaker":"Lance Baldo","startTime":484.02,"endTime":487.29,"body":"great career in industry.\" And"},{"speaker":"Lance Baldo","startTime":487.29,"endTime":489.0,"body":"that really stuck with me"},{"speaker":"Lance Baldo","startTime":487.29,"endTime":489.0,"body":"because there was this whole"},{"speaker":"Lance Baldo","startTime":489.0,"endTime":491.31,"body":"thing which I don't like when"},{"speaker":"Lance Baldo","startTime":489.0,"endTime":491.31,"body":"people say anymore, John. Like,"},{"speaker":"Lance Baldo","startTime":491.49,"endTime":493.38,"body":"you know, when you go to"},{"speaker":"Lance Baldo","startTime":491.49,"endTime":493.38,"body":"industry, you went to the dark"},{"speaker":"Lance Baldo","startTime":493.38,"endTime":497.61,"body":"side. I just don't think that's"},{"speaker":"Lance Baldo","startTime":493.38,"endTime":497.61,"body":"a truism. I think when you move"},{"speaker":"Lance Baldo","startTime":497.61,"endTime":500.91,"body":"from clinical medicine to"},{"speaker":"Lance Baldo","startTime":497.61,"endTime":500.91,"body":"industry, you can impact"},{"speaker":"Lance Baldo","startTime":500.91,"endTime":503.49,"body":"science, and you can impact"},{"speaker":"Lance Baldo","startTime":500.91,"endTime":503.49,"body":"patients, and you can impact"},{"speaker":"Lance Baldo","startTime":503.49,"endTime":506.79,"body":"society in just a much different"},{"speaker":"Lance Baldo","startTime":503.49,"endTime":506.79,"body":"way. That's all, and that's what"},{"speaker":"Lance Baldo","startTime":506.79,"endTime":509.46,"body":"I feel like I'm doing now as a"},{"speaker":"Lance Baldo","startTime":506.79,"endTime":509.46,"body":"physician working as a CEO."},{"speaker":"Lance Baldo","startTime":509.94,"endTime":512.58,"body":"When I was working abroad, John,"},{"speaker":"Lance Baldo","startTime":509.94,"endTime":512.58,"body":"so I had worked for Roche"},{"speaker":"Lance Baldo","startTime":512.58,"endTime":515.28,"body":"Genentech. So when I was working"},{"speaker":"Lance Baldo","startTime":512.58,"endTime":515.28,"body":"for Roche, I was primarily in"},{"speaker":"Lance Baldo","startTime":515.28,"endTime":518.49,"body":"Basel, Switzerland, for about"},{"speaker":"Lance Baldo","startTime":515.28,"endTime":518.49,"body":"five years, and then in New"},{"speaker":"Lance Baldo","startTime":518.49,"endTime":521.31,"body":"Zealand as a general manager,"},{"speaker":"Lance Baldo","startTime":518.49,"endTime":521.31,"body":"also for Roche for a couple of"},{"speaker":"Lance Baldo","startTime":521.31,"endTime":525.03,"body":"years, and the one area where I"},{"speaker":"Lance Baldo","startTime":521.31,"endTime":525.03,"body":"didn't have too much exposure"},{"speaker":"Lance Baldo","startTime":525.03,"endTime":529.71,"body":"was actually ophthalmology. And"},{"speaker":"Lance Baldo","startTime":525.03,"endTime":529.71,"body":"then one of the dream jobs that"},{"speaker":"Lance Baldo","startTime":529.71,"endTime":533.34,"body":"I wanted in Genentech was a job"},{"speaker":"Lance Baldo","startTime":529.71,"endTime":533.34,"body":"called franchise head, and I"},{"speaker":"Lance Baldo","startTime":533.34,"endTime":536.55,"body":"would have been pretty keen on"},{"speaker":"Lance Baldo","startTime":533.34,"endTime":536.55,"body":"almost any therapy area because"},{"speaker":"Lance Baldo","startTime":536.55,"endTime":539.37,"body":"that was kind of the dream job"},{"speaker":"Lance Baldo","startTime":536.55,"endTime":539.37,"body":"that I wanted to have. And one"},{"speaker":"Lance Baldo","startTime":539.37,"endTime":541.77,"body":"day I got a call from my manager"},{"speaker":"Lance Baldo","startTime":539.37,"endTime":541.77,"body":"saying, \"Hey, there's a"},{"speaker":"Lance Baldo","startTime":541.77,"endTime":545.55,"body":"franchise head job opening up in"},{"speaker":"Lance Baldo","startTime":541.77,"endTime":545.55,"body":"the U.S. and it happens to be"},{"speaker":"Lance Baldo","startTime":545.55,"endTime":548.85,"body":"ophthalmology, and the CEO of"},{"speaker":"Lance Baldo","startTime":545.55,"endTime":548.85,"body":"Genentech thinks you'd be"},{"speaker":"Lance Baldo","startTime":548.85,"endTime":553.29,"body":"perfect for it.\" And I remember"},{"speaker":"Lance Baldo","startTime":548.85,"endTime":553.29,"body":"I was like, \"I've never really"},{"speaker":"Lance Baldo","startTime":553.32,"endTime":556.74,"body":"focused on ophthalmology"},{"speaker":"Lance Baldo","startTime":553.32,"endTime":556.74,"body":"before.\" And what was said to me"},{"speaker":"Lance Baldo","startTime":556.74,"endTime":560.07,"body":"was, and this this happens to be"},{"speaker":"Lance Baldo","startTime":556.74,"endTime":560.07,"body":"a specific part of ophthalmology"},{"speaker":"Lance Baldo","startTime":560.07,"endTime":562.23,"body":"called retina. They said, you"},{"speaker":"Lance Baldo","startTime":560.07,"endTime":562.23,"body":"know, there's a lot of physician"},{"speaker":"Lance Baldo","startTime":562.23,"endTime":566.43,"body":"entrepreneurs. They like"},{"speaker":"Lance Baldo","startTime":562.23,"endTime":566.43,"body":"business minded, scientifically"},{"speaker":"Lance Baldo","startTime":566.43,"endTime":570.45,"body":"focused leadership, and we think"},{"speaker":"Lance Baldo","startTime":566.43,"endTime":570.45,"body":"you'd be great for it. And so it"},{"speaker":"Lance Baldo","startTime":570.45,"endTime":572.25,"body":"was a bit of leap of faith"},{"speaker":"Lance Baldo","startTime":570.45,"endTime":572.25,"body":"there, as well, when we started"},{"speaker":"Lance Baldo","startTime":572.25,"endTime":575.16,"body":"talking about leaps of faith in"},{"speaker":"Lance Baldo","startTime":572.25,"endTime":575.16,"body":"my career. And sure enough, you"},{"speaker":"Lance Baldo","startTime":575.16,"endTime":577.74,"body":"know, kudos to management there"},{"speaker":"Lance Baldo","startTime":575.16,"endTime":577.74,"body":"and kudos to leadership. They"},{"speaker":"Lance Baldo","startTime":577.74,"endTime":580.92,"body":"were right. Like, first couple"},{"speaker":"Lance Baldo","startTime":577.74,"endTime":580.92,"body":"weeks on the job, unlike when I"},{"speaker":"Lance Baldo","startTime":580.92,"endTime":584.04,"body":"moved over to Adaptive"},{"speaker":"Lance Baldo","startTime":580.92,"endTime":584.04,"body":"Biotechnologies, and I really,"},{"speaker":"Lance Baldo","startTime":584.04,"endTime":586.26,"body":"you know, and I really felt like"},{"speaker":"Lance Baldo","startTime":584.04,"endTime":586.26,"body":"I was drowning, I felt like I"},{"speaker":"Lance Baldo","startTime":586.26,"endTime":588.99,"body":"was like in my element right out"},{"speaker":"Lance Baldo","startTime":586.26,"endTime":588.99,"body":"of the gate at the beginning"},{"speaker":"Lance Baldo","startTime":588.99,"endTime":592.2,"body":"there, and it was a really"},{"speaker":"Lance Baldo","startTime":588.99,"endTime":592.2,"body":"formative part of my career. And"},{"speaker":"Lance Baldo","startTime":592.2,"endTime":595.44,"body":"again, it was one of those times"},{"speaker":"Lance Baldo","startTime":592.2,"endTime":595.44,"body":"I probably would have stayed,"},{"speaker":"Lance Baldo","startTime":595.68,"endTime":597.6,"body":"but when you're in a large"},{"speaker":"Lance Baldo","startTime":595.68,"endTime":597.6,"body":"company, sometimes other"},{"speaker":"Lance Baldo","startTime":597.6,"endTime":600.06,"body":"opportunities called, and I"},{"speaker":"Lance Baldo","startTime":597.6,"endTime":600.06,"body":"ended up getting promoted into a"},{"speaker":"Lance Baldo","startTime":600.06,"endTime":602.46,"body":"more senior role that happened"},{"speaker":"Lance Baldo","startTime":600.06,"endTime":602.46,"body":"to still have responsibility for"},{"speaker":"Lance Baldo","startTime":602.46,"endTime":605.85,"body":"ophthalmology, but it was across"},{"speaker":"Lance Baldo","startTime":602.46,"endTime":605.85,"body":"the whole Roche Genentech"},{"speaker":"Lance Baldo","startTime":605.91,"endTime":608.76,"body":"portfolio at that time. But it"},{"speaker":"Lance Baldo","startTime":605.91,"endTime":608.76,"body":"was another one of those times I"},{"speaker":"Lance Baldo","startTime":608.76,"endTime":611.4,"body":"could have stayed in retina for"},{"speaker":"Lance Baldo","startTime":608.76,"endTime":611.4,"body":"the rest of my career and been"},{"speaker":"Lance Baldo","startTime":611.4,"endTime":611.82,"body":"happy."},{"speaker":"John Simboli","startTime":612.69,"endTime":616.05,"body":"When you were"},{"speaker":"John Simboli","startTime":612.69,"endTime":616.05,"body":"thinking about becoming a CEO"},{"speaker":"John Simboli","startTime":616.05,"endTime":618.9,"body":"and kind of exploring the"},{"speaker":"John Simboli","startTime":616.05,"endTime":618.9,"body":"opportunities, I'm sure there"},{"speaker":"John Simboli","startTime":618.9,"endTime":623.91,"body":"were many that that you you saw"},{"speaker":"John Simboli","startTime":618.9,"endTime":623.91,"body":"and came to you and you thought"},{"speaker":"John Simboli","startTime":623.91,"endTime":626.4,"body":"through. Do you recall what it"},{"speaker":"John Simboli","startTime":623.91,"endTime":626.4,"body":"was about Beacon that really"},{"speaker":"John Simboli","startTime":626.43,"endTime":629.13,"body":"piqued your interest and said,"},{"speaker":"John Simboli","startTime":626.43,"endTime":629.13,"body":"\"I'd like to explore that?\""},{"speaker":"Lance Baldo","startTime":629.4,"endTime":631.77,"body":"I was exploring a"},{"speaker":"Lance Baldo","startTime":629.4,"endTime":631.77,"body":"different opportunity, which I"},{"speaker":"Lance Baldo","startTime":631.77,"endTime":635.91,"body":"was also quite keen on, and I"},{"speaker":"Lance Baldo","startTime":631.77,"endTime":635.91,"body":"decided to call a friend and a"},{"speaker":"Lance Baldo","startTime":635.91,"endTime":638.28,"body":"colleague of mine who actually"},{"speaker":"Lance Baldo","startTime":635.91,"endTime":638.28,"body":"was my hiring manager when I"},{"speaker":"Lance Baldo","startTime":638.28,"endTime":641.4,"body":"became the franchise head for"},{"speaker":"Lance Baldo","startTime":638.28,"endTime":641.4,"body":"ophthalmology at Genentech, and"},{"speaker":"Lance Baldo","startTime":641.4,"endTime":643.86,"body":"I called him up and I said,"},{"speaker":"Lance Baldo","startTime":641.4,"endTime":643.86,"body":"\"Hey, I'm thinking about, you"},{"speaker":"Lance Baldo","startTime":643.86,"endTime":647.4,"body":"know. my next step in my career,"},{"speaker":"Lance Baldo","startTime":643.86,"endTime":647.4,"body":"and I'd like to be a CEO. And"},{"speaker":"Lance Baldo","startTime":647.4,"endTime":649.2,"body":"this is a company I'm looking"},{"speaker":"Lance Baldo","startTime":647.4,"endTime":649.2,"body":"at. And he's like, \"Lance, are"},{"speaker":"Lance Baldo","startTime":649.2,"endTime":652.53,"body":"you considering CEO jobs in"},{"speaker":"Lance Baldo","startTime":649.2,"endTime":652.53,"body":"ophthalmology?\" And I said,"},{"speaker":"Lance Baldo","startTime":652.77,"endTime":657.99,"body":"\"Yes, I am.\" And he said, \"I've"},{"speaker":"Lance Baldo","startTime":652.77,"endTime":657.99,"body":"got a better one for you.\" And"},{"speaker":"Lance Baldo","startTime":657.99,"endTime":660.9,"body":"it turned out that better one"},{"speaker":"Lance Baldo","startTime":657.99,"endTime":660.9,"body":"was was Beacon Therapeutics, and"},{"speaker":"Lance Baldo","startTime":660.9,"endTime":663.66,"body":"truly, I mean, both"},{"speaker":"Lance Baldo","startTime":660.9,"endTime":663.66,"body":"opportunities are amazing"},{"speaker":"Lance Baldo","startTime":663.66,"endTime":666.63,"body":"opportunities in different ways."},{"speaker":"Lance Baldo","startTime":663.66,"endTime":666.63,"body":"But what was really appealing to"},{"speaker":"Lance Baldo","startTime":666.63,"endTime":669.69,"body":"me about Beacon Therapeutics is"},{"speaker":"Lance Baldo","startTime":666.63,"endTime":669.69,"body":"its clinical stage. We have a"},{"speaker":"Lance Baldo","startTime":669.69,"endTime":673.83,"body":"drug that's being studied,"},{"speaker":"Lance Baldo","startTime":669.69,"endTime":673.83,"body":"that's in patients right now,"},{"speaker":"Lance Baldo","startTime":673.86,"endTime":676.95,"body":"that's fairly close to knowing"},{"speaker":"Lance Baldo","startTime":673.86,"endTime":676.95,"body":"how well it works and whether or"},{"speaker":"Lance Baldo","startTime":676.95,"endTime":679.41,"body":"not you can bring it through the"},{"speaker":"Lance Baldo","startTime":676.95,"endTime":679.41,"body":"regulators and ultimately get it"},{"speaker":"Lance Baldo","startTime":679.41,"endTime":682.29,"body":"to patients. And that, to me,"},{"speaker":"Lance Baldo","startTime":679.41,"endTime":682.29,"body":"when I think through my career,"},{"speaker":"Lance Baldo","startTime":682.29,"endTime":684.99,"body":"that's where I feel like I could"},{"speaker":"Lance Baldo","startTime":682.29,"endTime":684.99,"body":"have the most impact is when"},{"speaker":"Lance Baldo","startTime":684.99,"endTime":687.27,"body":"things are in the clinic or"},{"speaker":"Lance Baldo","startTime":684.99,"endTime":687.27,"body":"getting pretty close to"},{"speaker":"Lance Baldo","startTime":687.27,"endTime":690.21,"body":"commercialization, and that's"},{"speaker":"Lance Baldo","startTime":687.27,"endTime":690.21,"body":"what really drew me to Beacon. I"},{"speaker":"Lance Baldo","startTime":690.21,"endTime":692.97,"body":"mean, there's some sexy"},{"speaker":"Lance Baldo","startTime":690.21,"endTime":692.97,"body":"technology, and there was some"},{"speaker":"Lance Baldo","startTime":692.97,"endTime":696.12,"body":"great investors and some really"},{"speaker":"Lance Baldo","startTime":692.97,"endTime":696.12,"body":"good people that I knew from my"},{"speaker":"Lance Baldo","startTime":696.12,"endTime":699.57,"body":"past, and all of that kind of"},{"speaker":"Lance Baldo","startTime":696.12,"endTime":699.57,"body":"just really built out Beacon as"},{"speaker":"Lance Baldo","startTime":699.57,"endTime":701.82,"body":"being the perfect package for"},{"speaker":"Lance Baldo","startTime":699.57,"endTime":701.82,"body":"me, and it's been great. I have"},{"speaker":"Lance Baldo","startTime":701.82,"endTime":704.88,"body":"to say, like this is an amazing"},{"speaker":"Lance Baldo","startTime":701.82,"endTime":704.88,"body":"experience for me. I tell my"},{"speaker":"Lance Baldo","startTime":704.88,"endTime":708.09,"body":"team, John, I pinch myself"},{"speaker":"Lance Baldo","startTime":704.88,"endTime":708.09,"body":"sometimes for the situation that"},{"speaker":"Lance Baldo","startTime":708.09,"endTime":712.83,"body":"I find myself in because many"},{"speaker":"Lance Baldo","startTime":708.09,"endTime":712.83,"body":"people in their careers, you"},{"speaker":"Lance Baldo","startTime":712.83,"endTime":716.01,"body":"know, you can you can usually"},{"speaker":"Lance Baldo","startTime":712.83,"endTime":716.01,"body":"count on one hand how many times"},{"speaker":"Lance Baldo","startTime":716.01,"endTime":719.16,"body":"you're involved in a pivotal"},{"speaker":"Lance Baldo","startTime":716.01,"endTime":719.16,"body":"phase three readout at a very"},{"speaker":"Lance Baldo","startTime":719.16,"endTime":721.53,"body":"close level. I mean, if you're a"},{"speaker":"Lance Baldo","startTime":719.16,"endTime":721.53,"body":"CEO of a big company, sure you"},{"speaker":"Lance Baldo","startTime":721.53,"endTime":725.04,"body":"may have a number, but at a"},{"speaker":"Lance Baldo","startTime":721.53,"endTime":725.04,"body":"small company, to be this close"},{"speaker":"Lance Baldo","startTime":725.34,"endTime":728.49,"body":"to where the rubber meets the"},{"speaker":"Lance Baldo","startTime":725.34,"endTime":728.49,"body":"road, it's really it's all it's"},{"speaker":"Lance Baldo","startTime":728.49,"endTime":731.04,"body":"all inspiring. Really, it's it's"},{"speaker":"Lance Baldo","startTime":728.49,"endTime":731.04,"body":"just an amazing place to be."},{"speaker":"John Simboli","startTime":731.88,"endTime":734.61,"body":"I know you can't"},{"speaker":"John Simboli","startTime":731.88,"endTime":734.61,"body":"predict the future, but if"},{"speaker":"John Simboli","startTime":734.79,"endTime":737.7,"body":"things develop at Beacon the"},{"speaker":"John Simboli","startTime":734.79,"endTime":737.7,"body":"way, you hope it will, and you"},{"speaker":"John Simboli","startTime":737.7,"endTime":741.0,"body":"can bring hope and change to"},{"speaker":"John Simboli","startTime":737.7,"endTime":741.0,"body":"patients. How would it affect"},{"speaker":"John Simboli","startTime":741.0,"endTime":742.86,"body":"their lives if you could do what"},{"speaker":"John Simboli","startTime":741.0,"endTime":742.86,"body":"you want to do?"},{"speaker":"Lance Baldo","startTime":743.16,"endTime":746.4,"body":"Our lead asset is a"},{"speaker":"Lance Baldo","startTime":743.16,"endTime":746.4,"body":"is a product called laru-zova,"},{"speaker":"Lance Baldo","startTime":746.43,"endTime":749.64,"body":"and it's for an indication"},{"speaker":"Lance Baldo","startTime":746.43,"endTime":749.64,"body":"called XLRP, and it's a genetic"},{"speaker":"Lance Baldo","startTime":749.64,"endTime":753.24,"body":"blindness, and it affects"},{"speaker":"Lance Baldo","startTime":749.64,"endTime":753.24,"body":"predominantly males. And these"},{"speaker":"Lance Baldo","startTime":753.27,"endTime":757.38,"body":"poor young men just slowly and"},{"speaker":"Lance Baldo","startTime":753.27,"endTime":757.38,"body":"progressively become more and"},{"speaker":"Lance Baldo","startTime":757.38,"endTime":760.59,"body":"more blind until it starts"},{"speaker":"Lance Baldo","startTime":757.38,"endTime":760.59,"body":"affecting the way they live,"},{"speaker":"Lance Baldo","startTime":760.62,"endTime":764.61,"body":"their ability to work, their"},{"speaker":"Lance Baldo","startTime":760.62,"endTime":764.61,"body":"inability to drive. So it's just"},{"speaker":"Lance Baldo","startTime":764.61,"endTime":768.09,"body":"devastating. And this word unmet"},{"speaker":"Lance Baldo","startTime":764.61,"endTime":768.09,"body":"need gets thrown around a lot,"},{"speaker":"Lance Baldo","startTime":768.09,"endTime":771.15,"body":"John. But here, there's"},{"speaker":"Lance Baldo","startTime":768.09,"endTime":771.15,"body":"absolutely nothing other than"},{"speaker":"Lance Baldo","startTime":771.18,"endTime":773.88,"body":"get your life in order that we"},{"speaker":"Lance Baldo","startTime":771.18,"endTime":773.88,"body":"can do for these patients. And"},{"speaker":"Lance Baldo","startTime":773.88,"endTime":778.29,"body":"the interesting thing is, not"},{"speaker":"Lance Baldo","startTime":773.88,"endTime":778.29,"body":"only does the medicine assist"},{"speaker":"Lance Baldo","startTime":778.32,"endTime":782.37,"body":"with making their vision better,"},{"speaker":"Lance Baldo","startTime":778.32,"endTime":782.37,"body":"it actually allows them to"},{"speaker":"Lance Baldo","startTime":782.37,"endTime":786.18,"body":"regain vision, so they actually"},{"speaker":"Lance Baldo","startTime":782.37,"endTime":786.18,"body":"can gain. And we've all done an"},{"speaker":"Lance Baldo","startTime":786.18,"endTime":791.01,"body":"eye chart. Imagine gaining one,"},{"speaker":"Lance Baldo","startTime":786.18,"endTime":791.01,"body":"two, or three lines—not"},{"speaker":"Lance Baldo","startTime":791.1,"endTime":793.83,"body":"letters—lines on an eye"},{"speaker":"Lance Baldo","startTime":791.1,"endTime":793.83,"body":"chart-and that's what we've seen"},{"speaker":"Lance Baldo","startTime":793.83,"endTime":797.31,"body":"in some of our phase two data."},{"speaker":"Lance Baldo","startTime":793.83,"endTime":797.31,"body":"And this is a gene therapy, so"},{"speaker":"Lance Baldo","startTime":797.31,"endTime":800.1,"body":"it is a needle in your eye. It"},{"speaker":"Lance Baldo","startTime":797.31,"endTime":800.1,"body":"happens to be done within an"},{"speaker":"Lance Baldo","startTime":800.1,"endTime":803.01,"body":"operating suite, but it's a"},{"speaker":"Lance Baldo","startTime":800.1,"endTime":803.01,"body":"needle in your eye, one time,"},{"speaker":"Lance Baldo","startTime":803.07,"endTime":806.73,"body":"which does help with kind of the"},{"speaker":"Lance Baldo","startTime":803.07,"endTime":806.73,"body":"treatment burden there as well,"},{"speaker":"Lance Baldo","startTime":806.73,"endTime":809.82,"body":"John. And that's for our first"},{"speaker":"Lance Baldo","startTime":806.73,"endTime":809.82,"body":"asset. For our second program,"},{"speaker":"Lance Baldo","startTime":809.85,"endTime":813.33,"body":"it is for a condition called dry"},{"speaker":"Lance Baldo","startTime":809.85,"endTime":813.33,"body":"AMD, where right now there is a"},{"speaker":"Lance Baldo","startTime":813.33,"endTime":815.73,"body":"big treatment burden because you"},{"speaker":"Lance Baldo","startTime":813.33,"endTime":815.73,"body":"do have to go back and get"},{"speaker":"Lance Baldo","startTime":815.73,"endTime":818.07,"body":"needles in your eye every month"},{"speaker":"Lance Baldo","startTime":815.73,"endTime":818.07,"body":"or two, and you actually don't"},{"speaker":"Lance Baldo","startTime":818.07,"endTime":823.2,"body":"feel any better. It arrests the"},{"speaker":"Lance Baldo","startTime":818.07,"endTime":823.2,"body":"progression of disease, but it"},{"speaker":"Lance Baldo","startTime":823.2,"endTime":826.77,"body":"doesn't make you see any better,"},{"speaker":"Lance Baldo","startTime":823.2,"endTime":826.77,"body":"and that's where we think that a"},{"speaker":"Lance Baldo","startTime":826.77,"endTime":830.64,"body":"gene therapy, a one-and-done"},{"speaker":"Lance Baldo","startTime":826.77,"endTime":830.64,"body":"therapy, could be hugely"},{"speaker":"Lance Baldo","startTime":830.64,"endTime":833.94,"body":"impactful for patients because"},{"speaker":"Lance Baldo","startTime":830.64,"endTime":833.94,"body":"theoretically it would be one"},{"speaker":"Lance Baldo","startTime":833.94,"endTime":836.16,"body":"injection, and they're going to"},{"speaker":"Lance Baldo","startTime":833.94,"endTime":836.16,"body":"get that lifelong benefit"},{"speaker":"Lance Baldo","startTime":836.16,"endTime":836.7,"body":"afterwards.,"},{"speaker":"John Simboli","startTime":837.48,"endTime":840.21,"body":"if I were to say,"},{"speaker":"John Simboli","startTime":837.48,"endTime":840.21,"body":"what is Lance's management"},{"speaker":"John Simboli","startTime":840.21,"endTime":842.97,"body":"approach? How does he get the"},{"speaker":"John Simboli","startTime":840.21,"endTime":842.97,"body":"best out of people? What do you"},{"speaker":"John Simboli","startTime":842.97,"endTime":843.72,"body":"think your team would say?"},{"speaker":"Lance Baldo","startTime":844.11,"endTime":847.59,"body":"I'm a very open"},{"speaker":"Lance Baldo","startTime":844.11,"endTime":847.59,"body":"leader. I tend to kind of wear"},{"speaker":"Lance Baldo","startTime":847.59,"endTime":851.64,"body":"my heart on my sleeve. I would"},{"speaker":"Lance Baldo","startTime":847.59,"endTime":851.64,"body":"often say that that I lead with"},{"speaker":"Lance Baldo","startTime":851.64,"endTime":854.58,"body":"my head and my heart, and I"},{"speaker":"Lance Baldo","startTime":851.64,"endTime":854.58,"body":"think people do see that. I'd"},{"speaker":"Lance Baldo","startTime":854.58,"endTime":856.89,"body":"like to think they would say I'm"},{"speaker":"Lance Baldo","startTime":854.58,"endTime":856.89,"body":"an empowering leader. I'm"},{"speaker":"Lance Baldo","startTime":856.89,"endTime":860.04,"body":"certainly not command and"},{"speaker":"Lance Baldo","startTime":856.89,"endTime":860.04,"body":"control. In fact, my belief, one"},{"speaker":"Lance Baldo","startTime":860.04,"endTime":863.4,"body":"of my strong beliefs in my"},{"speaker":"Lance Baldo","startTime":860.04,"endTime":863.4,"body":"career, is hire great people and"},{"speaker":"Lance Baldo","startTime":863.4,"endTime":865.92,"body":"then give them the space to"},{"speaker":"Lance Baldo","startTime":863.4,"endTime":865.92,"body":"actually operate and get on with"},{"speaker":"Lance Baldo","startTime":865.92,"endTime":870.93,"body":"what they need to do. I prefer"},{"speaker":"Lance Baldo","startTime":865.92,"endTime":870.93,"body":"consensus when we can, and so I"},{"speaker":"Lance Baldo","startTime":870.93,"endTime":874.2,"body":"always try to find what's that"},{"speaker":"Lance Baldo","startTime":870.93,"endTime":874.2,"body":"path of least resistance, to try"},{"speaker":"Lance Baldo","startTime":874.2,"endTime":877.08,"body":"to placate everybody to try to"},{"speaker":"Lance Baldo","startTime":874.2,"endTime":877.08,"body":"have a little bit more like"},{"speaker":"Lance Baldo","startTime":877.14,"endTime":879.6,"body":"harmony, you know, within the"},{"speaker":"Lance Baldo","startTime":877.14,"endTime":879.6,"body":"leadership team or within the"},{"speaker":"Lance Baldo","startTime":879.6,"endTime":882.18,"body":"organization. But that's"},{"speaker":"Lance Baldo","startTime":879.6,"endTime":882.18,"body":"something as a leader. When I"},{"speaker":"Lance Baldo","startTime":882.18,"endTime":884.34,"body":"think of what I struggle with,"},{"speaker":"Lance Baldo","startTime":882.18,"endTime":884.34,"body":"is sometimes you can't always"},{"speaker":"Lance Baldo","startTime":884.34,"endTime":886.53,"body":"have harmony, and sometimes you"},{"speaker":"Lance Baldo","startTime":884.34,"endTime":886.53,"body":"have to make the hard decision,"},{"speaker":"Lance Baldo","startTime":886.8,"endTime":889.17,"body":"and sometimes you have to"},{"speaker":"Lance Baldo","startTime":886.8,"endTime":889.17,"body":"realize that you're not going to"},{"speaker":"Lance Baldo","startTime":889.17,"endTime":890.73,"body":"make everyone happy all the"},{"speaker":"Lance Baldo","startTime":889.17,"endTime":890.73,"body":"time."},{"speaker":"John Simboli","startTime":891.42,"endTime":893.52,"body":"When you're in the"},{"speaker":"John Simboli","startTime":891.42,"endTime":893.52,"body":"the dreaded \"elevator"},{"speaker":"John Simboli","startTime":893.55,"endTime":896.37,"body":"situation,\" someone says, \"Hey,"},{"speaker":"John Simboli","startTime":893.55,"endTime":896.37,"body":"Lance, who is Beacon"},{"speaker":"John Simboli","startTime":896.37,"endTime":898.83,"body":"Therapeutics?\" What's the short"},{"speaker":"John Simboli","startTime":896.37,"endTime":898.83,"body":"answer you like to give?"},{"speaker":"Lance Baldo","startTime":899.34,"endTime":903.3,"body":"We focus on"},{"speaker":"Lance Baldo","startTime":899.34,"endTime":903.3,"body":"devastating causes of blindness"},{"speaker":"Lance Baldo","startTime":903.54,"endTime":907.68,"body":"and try to find specific genetic"},{"speaker":"Lance Baldo","startTime":903.54,"endTime":907.68,"body":"therapies, specifically gene"},{"speaker":"Lance Baldo","startTime":907.68,"endTime":911.94,"body":"therapies, to be able to make"},{"speaker":"Lance Baldo","startTime":907.68,"endTime":911.94,"body":"these patients treated or make"},{"speaker":"Lance Baldo","startTime":911.94,"endTime":915.0,"body":"them see better. And so, the"},{"speaker":"Lance Baldo","startTime":911.94,"endTime":915.0,"body":"very technical term is ocular"},{"speaker":"Lance Baldo","startTime":915.18,"endTime":918.36,"body":"gene therapy, but a different"},{"speaker":"Lance Baldo","startTime":915.18,"endTime":918.36,"body":"way is using genetic medicines,"},{"speaker":"Lance Baldo","startTime":918.66,"endTime":921.93,"body":"putting them in the eye, and"},{"speaker":"Lance Baldo","startTime":918.66,"endTime":921.93,"body":"hopefully allowing patients and"},{"speaker":"Lance Baldo","startTime":921.93,"endTime":924.3,"body":"allowing people to see better."},{"speaker":"Lance Baldo","startTime":921.93,"endTime":924.3,"body":"That's what we do."},{"speaker":"Lance Baldo","startTime":924.63,"endTime":929.13,"body":"When you look at gene therapy,"},{"speaker":"Lance Baldo","startTime":924.63,"endTime":929.13,"body":"the eye is an ideal organ for"},{"speaker":"Lance Baldo","startTime":929.13,"endTime":932.55,"body":"making advancements within this"},{"speaker":"Lance Baldo","startTime":929.13,"endTime":932.55,"body":"space. It's an encapsulated"},{"speaker":"Lance Baldo","startTime":932.55,"endTime":935.97,"body":"organ, has something called"},{"speaker":"Lance Baldo","startTime":932.55,"endTime":935.97,"body":"immune privilege. So generally,"},{"speaker":"Lance Baldo","startTime":935.97,"endTime":938.82,"body":"it's a little bit harder for"},{"speaker":"Lance Baldo","startTime":935.97,"endTime":938.82,"body":"stuff that gets into the eye to"},{"speaker":"Lance Baldo","startTime":938.82,"endTime":941.82,"body":"get more broadly into the"},{"speaker":"Lance Baldo","startTime":938.82,"endTime":941.82,"body":"circulation. And there's a whole"},{"speaker":"Lance Baldo","startTime":941.82,"endTime":944.25,"body":"bunch of tests we can do, and"},{"speaker":"Lance Baldo","startTime":941.82,"endTime":944.25,"body":"we've already kind of mentioned"},{"speaker":"Lance Baldo","startTime":944.25,"endTime":946.5,"body":"some of them with the vision"},{"speaker":"Lance Baldo","startTime":944.25,"endTime":946.5,"body":"chart. It's a whole bunch of"},{"speaker":"Lance Baldo","startTime":946.5,"endTime":949.86,"body":"tests that we can do to see if"},{"speaker":"Lance Baldo","startTime":946.5,"endTime":949.86,"body":"the interventions that we're"},{"speaker":"Lance Baldo","startTime":949.86,"endTime":954.45,"body":"making are actually improving"},{"speaker":"Lance Baldo","startTime":949.86,"endTime":954.45,"body":"outcomes in patients. And so"},{"speaker":"Lance Baldo","startTime":954.48,"endTime":957.57,"body":"it's my personal belief that"},{"speaker":"Lance Baldo","startTime":954.48,"endTime":957.57,"body":"over time we're going to take"},{"speaker":"Lance Baldo","startTime":957.57,"endTime":960.3,"body":"some of the great learnings that"},{"speaker":"Lance Baldo","startTime":957.57,"endTime":960.3,"body":"we're gaining in ocular gene"},{"speaker":"Lance Baldo","startTime":960.3,"endTime":963.75,"body":"therapy and then apply that to"},{"speaker":"Lance Baldo","startTime":960.3,"endTime":963.75,"body":"other organ systems across the"},{"speaker":"Lance Baldo","startTime":963.75,"endTime":966.48,"body":"body, as well as in more"},{"speaker":"Lance Baldo","startTime":963.75,"endTime":966.48,"body":"systemic gene therapy."},{"speaker":"John Simboli","startTime":968.1,"endTime":969.75,"body":"You must"},{"speaker":"John Simboli","startTime":968.1,"endTime":969.75,"body":"frequently get the question of,"},{"speaker":"John Simboli","startTime":970.29,"endTime":972.99,"body":"\"Well, it's awfully hard to do"},{"speaker":"John Simboli","startTime":970.29,"endTime":972.99,"body":"this, Lance, other people have"},{"speaker":"John Simboli","startTime":972.99,"endTime":976.59,"body":"tried. Why are you trying?\""},{"speaker":"John Simboli","startTime":972.99,"endTime":976.59,"body":"Where do you go with that?"},{"speaker":"Lance Baldo","startTime":976.83,"endTime":980.88,"body":"I hearken back to"},{"speaker":"Lance Baldo","startTime":976.83,"endTime":980.88,"body":"some of the innovations of the"},{"speaker":"Lance Baldo","startTime":980.88,"endTime":985.47,"body":"last 15 or 20 years,"},{"speaker":"Lance Baldo","startTime":980.88,"endTime":985.47,"body":"particularly biologics. So using"},{"speaker":"Lance Baldo","startTime":985.47,"endTime":989.46,"body":"monoclonal antibodies to treat"},{"speaker":"Lance Baldo","startTime":985.47,"endTime":989.46,"body":"disease, and I just remember it"},{"speaker":"Lance Baldo","startTime":989.46,"endTime":992.37,"body":"was like, wow, this was going to"},{"speaker":"Lance Baldo","startTime":989.46,"endTime":992.37,"body":"be like science fiction. Using,"},{"speaker":"Lance Baldo","startTime":992.4,"endTime":995.76,"body":"you know, using antibodies to"},{"speaker":"Lance Baldo","startTime":992.4,"endTime":995.76,"body":"treat these devastating"},{"speaker":"Lance Baldo","startTime":995.76,"endTime":999.75,"body":"conditions. Now we use them . ."},{"speaker":"Lance Baldo","startTime":995.76,"endTime":999.75,"body":". ubiquitous is maybe too strong"},{"speaker":"Lance Baldo","startTime":999.75,"endTime":1002.51,"body":"a word, but they're used to"},{"speaker":"Lance Baldo","startTime":999.75,"endTime":1002.51,"body":"treat all kinds of conditions."},{"speaker":"Lance Baldo","startTime":1002.51,"endTime":1005.87,"body":"And I truly believe that gene"},{"speaker":"Lance Baldo","startTime":1002.51,"endTime":1005.87,"body":"therapy is at that same"},{"speaker":"Lance Baldo","startTime":1005.87,"endTime":1008.54,"body":"precipice. That we're looking at"},{"speaker":"Lance Baldo","startTime":1005.87,"endTime":1008.54,"body":"it now and saying, \"Hey, this is"},{"speaker":"Lance Baldo","startTime":1008.54,"endTime":1010.76,"body":"hard, and there may only be a"},{"speaker":"Lance Baldo","startTime":1008.54,"endTime":1010.76,"body":"few places where this is going"},{"speaker":"Lance Baldo","startTime":1010.76,"endTime":1014.33,"body":"to benefit.\" Then, John, we're"},{"speaker":"Lance Baldo","startTime":1010.76,"endTime":1014.33,"body":"going to look back in five or 10"},{"speaker":"Lance Baldo","startTime":1014.36,"endTime":1017.66,"body":"or maybe 20 years and say, \"Wow,"},{"speaker":"Lance Baldo","startTime":1014.36,"endTime":1017.66,"body":"you know, this really made a lot"},{"speaker":"Lance Baldo","startTime":1017.66,"endTime":1020.99,"body":"of sense at that time.\" If you"},{"speaker":"Lance Baldo","startTime":1017.66,"endTime":1020.99,"body":"come out of the gates too fast,"},{"speaker":"Lance Baldo","startTime":1020.99,"endTime":1023.36,"body":"and you think you're going to"},{"speaker":"Lance Baldo","startTime":1020.99,"endTime":1023.36,"body":"like fix everything, and you"},{"speaker":"Lance Baldo","startTime":1023.36,"endTime":1026.33,"body":"think you're going to have all"},{"speaker":"Lance Baldo","startTime":1023.36,"endTime":1026.33,"body":"this, you know, perfect success."},{"speaker":"Lance Baldo","startTime":1026.57,"endTime":1028.67,"body":"You're going to be sorely"},{"speaker":"Lance Baldo","startTime":1026.57,"endTime":1028.67,"body":"mistaken, and so I'll tell"},{"speaker":"Lance Baldo","startTime":1028.67,"endTime":1031.58,"body":"people it is a marathon and not"},{"speaker":"Lance Baldo","startTime":1028.67,"endTime":1031.58,"body":"a sprint, and just be prepared"},{"speaker":"Lance Baldo","startTime":1031.58,"endTime":1032.63,"body":"for the long game in this."},{"speaker":"John Simboli","startTime":1033.2,"endTime":1035.93,"body":"How does the"},{"speaker":"John Simboli","startTime":1033.2,"endTime":1035.93,"body":"pipeline express your vision for"},{"speaker":"John Simboli","startTime":1035.93,"endTime":1037.19,"body":"the company going forward?"},{"speaker":"Lance Baldo","startTime":1037.46,"endTime":1040.13,"body":"Our pivotal study,"},{"speaker":"Lance Baldo","startTime":1037.46,"endTime":1040.13,"body":"the registrational study, it's"},{"speaker":"Lance Baldo","startTime":1040.13,"endTime":1043.01,"body":"called VISTA, fully enrolled"},{"speaker":"Lance Baldo","startTime":1040.13,"endTime":1043.01,"body":"last year, and it's going to be"},{"speaker":"Lance Baldo","startTime":1043.01,"endTime":1045.62,"body":"reading out towards the end of"},{"speaker":"Lance Baldo","startTime":1043.01,"endTime":1045.62,"body":"this year. And this is going to"},{"speaker":"Lance Baldo","startTime":1045.62,"endTime":1048.11,"body":"be one of the foundations for"},{"speaker":"Lance Baldo","startTime":1045.62,"endTime":1048.11,"body":"the company, to kind of build"},{"speaker":"Lance Baldo","startTime":1048.26,"endTime":1051.41,"body":"some of the infrastructure that"},{"speaker":"Lance Baldo","startTime":1048.26,"endTime":1051.41,"body":"we need around that, and also to"},{"speaker":"Lance Baldo","startTime":1051.41,"endTime":1054.14,"body":"be able to kind of give the"},{"speaker":"Lance Baldo","startTime":1051.41,"endTime":1054.14,"body":"confidence in our investors,"},{"speaker":"Lance Baldo","startTime":1054.23,"endTime":1056.27,"body":"whether that's going to be"},{"speaker":"Lance Baldo","startTime":1054.23,"endTime":1056.27,"body":"private investors or eventual"},{"speaker":"Lance Baldo","startTime":1056.27,"endTime":1059.06,"body":"public investors, if we choose"},{"speaker":"Lance Baldo","startTime":1056.27,"endTime":1059.06,"body":"that route, to be able to kind"},{"speaker":"Lance Baldo","startTime":1059.06,"endTime":1062.24,"body":"of continue to invest in the"},{"speaker":"Lance Baldo","startTime":1059.06,"endTime":1062.24,"body":"portfolio as well. The second"},{"speaker":"Lance Baldo","startTime":1062.27,"endTime":1065.96,"body":"program that we have is going to"},{"speaker":"Lance Baldo","startTime":1062.27,"endTime":1065.96,"body":"be going into the clinic towards"},{"speaker":"Lance Baldo","startTime":1065.96,"endTime":1068.45,"body":"the latter half of this year,"},{"speaker":"Lance Baldo","startTime":1065.96,"endTime":1068.45,"body":"and so we're opening a so-called"},{"speaker":"Lance Baldo","startTime":1068.48,"endTime":1072.71,"body":"IND or investigational new drug"},{"speaker":"Lance Baldo","startTime":1068.48,"endTime":1072.71,"body":"application, and then that will"},{"speaker":"Lance Baldo","startTime":1072.71,"endTime":1076.79,"body":"allow us to enter the clinic or"},{"speaker":"Lance Baldo","startTime":1072.71,"endTime":1076.79,"body":"start testing the medicine in"},{"speaker":"Lance Baldo","startTime":1076.79,"endTime":1079.64,"body":"patients and subjects towards"},{"speaker":"Lance Baldo","startTime":1076.79,"endTime":1079.64,"body":"the latter half of this year."},{"speaker":"Lance Baldo","startTime":1079.67,"endTime":1082.88,"body":"And then that allows us to kind"},{"speaker":"Lance Baldo","startTime":1079.67,"endTime":1082.88,"body":"of continue to progress that"},{"speaker":"Lance Baldo","startTime":1082.88,"endTime":1086.99,"body":"portfolio and mature that"},{"speaker":"Lance Baldo","startTime":1082.88,"endTime":1086.99,"body":"portfolio over time. The big"},{"speaker":"Lance Baldo","startTime":1086.99,"endTime":1089.03,"body":"challenge that we'll have in"},{"speaker":"Lance Baldo","startTime":1086.99,"endTime":1089.03,"body":"front of us will be"},{"speaker":"Lance Baldo","startTime":1089.03,"endTime":1093.02,"body":"commercialization of the lead"},{"speaker":"Lance Baldo","startTime":1089.03,"endTime":1093.02,"body":"asset, kind of getting ramped up"},{"speaker":"Lance Baldo","startTime":1093.02,"endTime":1094.64,"body":"and getting prepared for that as"},{"speaker":"Lance Baldo","startTime":1093.02,"endTime":1094.64,"body":"well."},{"speaker":"John Simboli","startTime":1095.15,"endTime":1097.52,"body":"What can you tell"},{"speaker":"John Simboli","startTime":1095.15,"endTime":1097.52,"body":"me about the mechanism of action"},{"speaker":"John Simboli","startTime":1097.52,"endTime":1098.6,"body":"for the lead candidate"},{"speaker":"Lance Baldo","startTime":1099.11,"endTime":1101.84,"body":"in this particular"},{"speaker":"Lance Baldo","startTime":1099.11,"endTime":1101.84,"body":"disease, called X-linked"},{"speaker":"Lance Baldo","startTime":1101.84,"endTime":1105.95,"body":"retinitis pigmentosa, it is a"},{"speaker":"Lance Baldo","startTime":1101.84,"endTime":1105.95,"body":"disease that affects the"},{"speaker":"Lance Baldo","startTime":1105.95,"endTime":1109.31,"body":"photoreceptors in the back of"},{"speaker":"Lance Baldo","startTime":1105.95,"endTime":1109.31,"body":"the eye. So these are the cells"},{"speaker":"Lance Baldo","startTime":1109.31,"endTime":1112.91,"body":"in the back of the eye that pick"},{"speaker":"Lance Baldo","startTime":1109.31,"endTime":1112.91,"body":"up light stimuli and then send"},{"speaker":"Lance Baldo","startTime":1112.91,"endTime":1115.49,"body":"that message to your brain, so"},{"speaker":"Lance Baldo","startTime":1112.91,"endTime":1115.49,"body":"that you can see, so that you"},{"speaker":"Lance Baldo","startTime":1115.49,"endTime":1120.41,"body":"can distinguish colors, etc. In"},{"speaker":"Lance Baldo","startTime":1115.49,"endTime":1120.41,"body":"this case, there is a mutation"},{"speaker":"Lance Baldo","startTime":1120.44,"endTime":1124.4,"body":"in a particular gene called"},{"speaker":"Lance Baldo","startTime":1120.44,"endTime":1124.4,"body":"RPGR, and that protein, that"},{"speaker":"Lance Baldo","startTime":1124.4,"endTime":1128.21,"body":"RPGR protein, localizes to an"},{"speaker":"Lance Baldo","startTime":1124.4,"endTime":1128.21,"body":"area within those"},{"speaker":"Lance Baldo","startTime":1128.21,"endTime":1132.59,"body":"photoreceptors, and it allows"},{"speaker":"Lance Baldo","startTime":1128.21,"endTime":1132.59,"body":"for protein transport and energy"},{"speaker":"Lance Baldo","startTime":1132.59,"endTime":1136.76,"body":"metabolism. And so, when that"},{"speaker":"Lance Baldo","startTime":1132.59,"endTime":1136.76,"body":"protein is mutated, basically,"},{"speaker":"Lance Baldo","startTime":1136.76,"endTime":1140.03,"body":"those cells stop behaving the"},{"speaker":"Lance Baldo","startTime":1136.76,"endTime":1140.03,"body":"way they should behave, and"},{"speaker":"Lance Baldo","startTime":1140.03,"endTime":1144.35,"body":"that's why you get initially"},{"speaker":"Lance Baldo","startTime":1140.03,"endTime":1144.35,"body":"degradation in vision, and then"},{"speaker":"Lance Baldo","startTime":1144.35,"endTime":1147.74,"body":"over time, unfortunately, John,"},{"speaker":"Lance Baldo","startTime":1144.35,"endTime":1147.74,"body":"those photoreceptors will"},{"speaker":"Lance Baldo","startTime":1147.74,"endTime":1151.34,"body":"eventually just die. And"},{"speaker":"Lance Baldo","startTime":1147.74,"endTime":1151.34,"body":"therefore it's very hard, if not"},{"speaker":"Lance Baldo","startTime":1151.34,"endTime":1153.26,"body":"impossible, to get them to work"},{"speaker":"Lance Baldo","startTime":1151.34,"endTime":1153.26,"body":"anymore."},{"speaker":"Lance Baldo","startTime":1153.53,"endTime":1158.12,"body":"What we do is we take a gene"},{"speaker":"Lance Baldo","startTime":1153.53,"endTime":1158.12,"body":"therapy that's called an AAV, an"},{"speaker":"Lance Baldo","startTime":1158.15,"endTime":1162.32,"body":"adeno-associated virus vector."},{"speaker":"Lance Baldo","startTime":1158.15,"endTime":1162.32,"body":"We put that in the back of the"},{"speaker":"Lance Baldo","startTime":1162.32,"endTime":1165.26,"body":"eye, so we try to get it as"},{"speaker":"Lance Baldo","startTime":1162.32,"endTime":1165.26,"body":"close to those photoreceptors as"},{"speaker":"Lance Baldo","startTime":1165.26,"endTime":1169.01,"body":"we can. The gene therapy gets"},{"speaker":"Lance Baldo","startTime":1165.26,"endTime":1169.01,"body":"taken up by the cells, and then"},{"speaker":"Lance Baldo","startTime":1169.01,"endTime":1172.67,"body":"we code for that protein within"},{"speaker":"Lance Baldo","startTime":1169.01,"endTime":1172.67,"body":"the gene that's within. That"},{"speaker":"Lance Baldo","startTime":1172.67,"endTime":1176.27,"body":"gene therapy. And then those"},{"speaker":"Lance Baldo","startTime":1172.67,"endTime":1176.27,"body":"photoreceptors start producing"},{"speaker":"Lance Baldo","startTime":1176.27,"endTime":1179.3,"body":"that protein. But amazingly,"},{"speaker":"Lance Baldo","startTime":1176.27,"endTime":1179.3,"body":"that protein goes to where it's"},{"speaker":"Lance Baldo","startTime":1179.3,"endTime":1182.75,"body":"supposed to be and allows those"},{"speaker":"Lance Baldo","startTime":1179.3,"endTime":1182.75,"body":"photoreceptors to start working"},{"speaker":"Lance Baldo","startTime":1182.81,"endTime":1185.57,"body":"the right way again, and"},{"speaker":"Lance Baldo","startTime":1182.81,"endTime":1185.57,"body":"therefore they're starting to"},{"speaker":"Lance Baldo","startTime":1185.57,"endTime":1188.81,"body":"send the light signals back to"},{"speaker":"Lance Baldo","startTime":1185.57,"endTime":1188.81,"body":"the brain, and people can start"},{"speaker":"Lance Baldo","startTime":1188.81,"endTime":1192.44,"body":"to see more letters. People can"},{"speaker":"Lance Baldo","startTime":1188.81,"endTime":1192.44,"body":"start to see more lines, and so"},{"speaker":"Lance Baldo","startTime":1192.95,"endTime":1196.49,"body":"it's that combination of knowing"},{"speaker":"Lance Baldo","startTime":1192.95,"endTime":1196.49,"body":"exactly the genetic disease and"},{"speaker":"Lance Baldo","startTime":1196.49,"endTime":1199.79,"body":"exactly the protein that kind of"},{"speaker":"Lance Baldo","startTime":1196.49,"endTime":1199.79,"body":"needs to be replaced, and then"},{"speaker":"Lance Baldo","startTime":1199.79,"endTime":1202.55,"body":"making sure that we get it to"},{"speaker":"Lance Baldo","startTime":1199.79,"endTime":1202.55,"body":"the right place in the back of"},{"speaker":"Lance Baldo","startTime":1202.55,"endTime":1204.38,"body":"the eye near those"},{"speaker":"Lance Baldo","startTime":1202.55,"endTime":1204.38,"body":"photoreceptors."},{"speaker":"John Simboli","startTime":1205.1,"endTime":1208.58,"body":"When you describe"},{"speaker":"John Simboli","startTime":1205.1,"endTime":1208.58,"body":"that mechanism of action to a"},{"speaker":"John Simboli","startTime":1208.58,"endTime":1212.81,"body":"sophisticated audience, let's"},{"speaker":"John Simboli","startTime":1208.58,"endTime":1212.81,"body":"say to an investor conference,"},{"speaker":"John Simboli","startTime":1213.23,"endTime":1216.32,"body":"and you get the folks who say,"},{"speaker":"John Simboli","startTime":1213.23,"endTime":1216.32,"body":"\"Yeah, I'm interested. Let's"},{"speaker":"John Simboli","startTime":1216.32,"endTime":1219.11,"body":"talk more. Then you get the"},{"speaker":"John Simboli","startTime":1216.32,"endTime":1219.11,"body":"people who say, \"No, this this"},{"speaker":"John Simboli","startTime":1219.11,"endTime":1221.0,"body":"is not something I'm interested"},{"speaker":"John Simboli","startTime":1219.11,"endTime":1221.0,"body":"in. There's that interest."},{"speaker":"John Simboli","startTime":1221.0,"endTime":1223.4,"body":"There's that third category"},{"speaker":"John Simboli","startTime":1221.0,"endTime":1223.4,"body":"sometimes where people say, \"Oh"},{"speaker":"yeah, I understand,\"","startTime":1223.58,"endTime":1226.28,"body":"and then"},{"speaker":"yeah, I understand,\"","startTime":1223.58,"endTime":1226.28,"body":"you realize they didn't"},{"speaker":"yeah, I understand,\"","startTime":1226.28,"endTime":1227.15,"body":"understand it."},{"speaker":"Lance Baldo","startTime":1227.66,"endTime":1230.9,"body":"The disconnect is a"},{"speaker":"Lance Baldo","startTime":1227.66,"endTime":1230.9,"body":"lot of people are thinking"},{"speaker":"Lance Baldo","startTime":1230.9,"endTime":1233.75,"body":"about, like for instance,"},{"speaker":"Lance Baldo","startTime":1230.9,"endTime":1233.75,"body":"systemic gene therapy, that you"},{"speaker":"Lance Baldo","startTime":1233.75,"endTime":1236.69,"body":"kind of give the medicine and"},{"speaker":"Lance Baldo","startTime":1233.75,"endTime":1236.69,"body":"it's going to be taken up by,"},{"speaker":"Lance Baldo","startTime":1236.72,"endTime":1239.0,"body":"you know, other cells of"},{"speaker":"Lance Baldo","startTime":1236.72,"endTime":1239.0,"body":"interest and start producing"},{"speaker":"Lance Baldo","startTime":1239.0,"endTime":1241.58,"body":"something that's going. In this"},{"speaker":"Lance Baldo","startTime":1239.0,"endTime":1241.58,"body":"case, I think we have to make it"},{"speaker":"Lance Baldo","startTime":1241.58,"endTime":1244.22,"body":"very clear, and I'll often start"},{"speaker":"Lance Baldo","startTime":1241.58,"endTime":1244.22,"body":"with, \"Hey, this medicine is"},{"speaker":"Lance Baldo","startTime":1244.22,"endTime":1247.1,"body":"being administered in the back"},{"speaker":"Lance Baldo","startTime":1244.22,"endTime":1247.1,"body":"of the eye. We're trying to get"},{"speaker":"Lance Baldo","startTime":1247.1,"endTime":1250.13,"body":"it as close as possible to those"},{"speaker":"Lance Baldo","startTime":1247.1,"endTime":1250.13,"body":"cells of cell cells of interest,"},{"speaker":"Lance Baldo","startTime":1250.13,"endTime":1252.92,"body":"the ones that we actually want"},{"speaker":"Lance Baldo","startTime":1250.13,"endTime":1252.92,"body":"to make sure we can get to start"},{"speaker":"Lance Baldo","startTime":1252.92,"endTime":1255.74,"body":"functioning again\". That's"},{"speaker":"Lance Baldo","startTime":1252.92,"endTime":1255.74,"body":"probably the most common. I"},{"speaker":"Lance Baldo","startTime":1255.74,"endTime":1258.98,"body":"think probably the most common"},{"speaker":"Lance Baldo","startTime":1255.74,"endTime":1258.98,"body":"objection that we get are people"},{"speaker":"Lance Baldo","startTime":1258.98,"endTime":1261.71,"body":"worried about safety. They kind"},{"speaker":"Lance Baldo","startTime":1258.98,"endTime":1261.71,"body":"of read through some of the"},{"speaker":"Lance Baldo","startTime":1261.71,"endTime":1264.77,"body":"safety issues we've seen with"},{"speaker":"Lance Baldo","startTime":1261.71,"endTime":1264.77,"body":"systemic gene therapy, and they"},{"speaker":"Lance Baldo","startTime":1264.77,"endTime":1268.28,"body":"just apply that errantly to the"},{"speaker":"Lance Baldo","startTime":1264.77,"endTime":1268.28,"body":"eye. And I think that's where I"},{"speaker":"Lance Baldo","startTime":1268.28,"endTime":1270.71,"body":"spend a lot of my time on"},{"speaker":"Lance Baldo","startTime":1268.28,"endTime":1270.71,"body":"education as to hey, it's not"},{"speaker":"Lance Baldo","startTime":1270.71,"endTime":1273.17,"body":"that these drugs are completely"},{"speaker":"Lance Baldo","startTime":1270.71,"endTime":1273.17,"body":"safe, John. There's no such"},{"speaker":"Lance Baldo","startTime":1273.17,"endTime":1276.11,"body":"thing as a drug that's"},{"speaker":"Lance Baldo","startTime":1273.17,"endTime":1276.11,"body":"completely safe. But I already"},{"speaker":"Lance Baldo","startTime":1276.11,"endTime":1278.51,"body":"described a little bit about the"},{"speaker":"Lance Baldo","startTime":1276.11,"endTime":1278.51,"body":"eye and some of the ways that we"},{"speaker":"Lance Baldo","startTime":1278.51,"endTime":1281.39,"body":"can manage some of the side"},{"speaker":"Lance Baldo","startTime":1278.51,"endTime":1281.39,"body":"effects. And so, probably the"},{"speaker":"Lance Baldo","startTime":1281.39,"endTime":1284.57,"body":"most common objection I get is,"},{"speaker":"Lance Baldo","startTime":1281.39,"endTime":1284.57,"body":"\"Hey, we've seen that these"},{"speaker":"Lance Baldo","startTime":1284.57,"endTime":1288.47,"body":"drugs could be unsafe in disease"},{"speaker":"Lance Baldo","startTime":1284.57,"endTime":1288.47,"body":"X, Y, or Z. Explain to me why"},{"speaker":"Lance Baldo","startTime":1288.47,"endTime":1290.93,"body":"it's going to be different in"},{"speaker":"Lance Baldo","startTime":1288.47,"endTime":1290.93,"body":"the diseases you're working on"},{"speaker":"Lance Baldo","startTime":1290.93,"endTime":1293.24,"body":"as well.\" So that's probably"},{"speaker":"Lance Baldo","startTime":1290.93,"endTime":1293.24,"body":"where I spend the largest part"},{"speaker":"Lance Baldo","startTime":1293.24,"endTime":1293.9,"body":"of my time."},{"speaker":"John Simboli","startTime":1294.65,"endTime":1297.2,"body":"What makes a good"},{"speaker":"John Simboli","startTime":1294.65,"endTime":1297.2,"body":"partner to Beacon Therapeutics?"},{"speaker":"Lance Baldo","startTime":1297.44,"endTime":1299.6,"body":"I'm hoping this is"},{"speaker":"Lance Baldo","startTime":1297.44,"endTime":1299.6,"body":"going to be amazing medicine"},{"speaker":"Lance Baldo","startTime":1299.6,"endTime":1303.08,"body":"that can help tens of thousands"},{"speaker":"Lance Baldo","startTime":1299.6,"endTime":1303.08,"body":"of people around the world. We"},{"speaker":"Lance Baldo","startTime":1303.08,"endTime":1306.62,"body":"simply at Beacon . . .it's"},{"speaker":"Lance Baldo","startTime":1303.08,"endTime":1306.62,"body":"unlikely that we ever will build"},{"speaker":"Lance Baldo","startTime":1306.62,"endTime":1308.72,"body":"the infrastructure that we need"},{"speaker":"Lance Baldo","startTime":1306.62,"endTime":1308.72,"body":"around the world to make sure"},{"speaker":"Lance Baldo","startTime":1308.72,"endTime":1311.51,"body":"that all these patients"},{"speaker":"Lance Baldo","startTime":1308.72,"endTime":1311.51,"body":"potentially could benefit. So"},{"speaker":"Lance Baldo","startTime":1311.51,"endTime":1314.42,"body":"we're looking at potential"},{"speaker":"Lance Baldo","startTime":1311.51,"endTime":1314.42,"body":"partners to help us to"},{"speaker":"Lance Baldo","startTime":1314.45,"endTime":1317.18,"body":"commercialize, to help us to"},{"speaker":"Lance Baldo","startTime":1314.45,"endTime":1317.18,"body":"distribute this medicine from"},{"speaker":"Lance Baldo","startTime":1317.18,"endTime":1320.0,"body":"around the world. In that"},{"speaker":"Lance Baldo","startTime":1317.18,"endTime":1320.0,"body":"setting, what makes a good"},{"speaker":"Lance Baldo","startTime":1320.0,"endTime":1322.61,"body":"partner, and this is where the"},{"speaker":"Lance Baldo","startTime":1320.0,"endTime":1322.61,"body":"the clinician and me comes out."},{"speaker":"Lance Baldo","startTime":1323.0,"endTime":1327.53,"body":"I want a partner that's going to"},{"speaker":"Lance Baldo","startTime":1323.0,"endTime":1327.53,"body":"take the gravitas that it means"},{"speaker":"Lance Baldo","startTime":1327.53,"endTime":1330.08,"body":"to, like, have the"},{"speaker":"Lance Baldo","startTime":1327.53,"endTime":1330.08,"body":"responsibility to try to get"},{"speaker":"Lance Baldo","startTime":1330.08,"endTime":1332.42,"body":"this medicine, these people, and"},{"speaker":"Lance Baldo","startTime":1330.08,"endTime":1332.42,"body":"that they take it as seriously"},{"speaker":"Lance Baldo","startTime":1332.6,"endTime":1336.68,"body":"as I would personally. Because I"},{"speaker":"Lance Baldo","startTime":1332.6,"endTime":1336.68,"body":"don't want this to get lost in a"},{"speaker":"Lance Baldo","startTime":1336.68,"endTime":1339.65,"body":"company where it's simply not"},{"speaker":"Lance Baldo","startTime":1336.68,"endTime":1339.65,"body":"important. I don't want it to be"},{"speaker":"Lance Baldo","startTime":1339.74,"endTime":1342.77,"body":"struggling in a company that"},{"speaker":"Lance Baldo","startTime":1339.74,"endTime":1342.77,"body":"simply doesn't invest behind it."},{"speaker":"Lance Baldo","startTime":1343.01,"endTime":1347.42,"body":"I mean, ideally, I'd like to"},{"speaker":"Lance Baldo","startTime":1343.01,"endTime":1347.42,"body":"find a partner that considers"},{"speaker":"Lance Baldo","startTime":1347.42,"endTime":1349.61,"body":"this to be a pillar of their"},{"speaker":"Lance Baldo","startTime":1347.42,"endTime":1349.61,"body":"business, and they're going to"},{"speaker":"Lance Baldo","startTime":1349.61,"endTime":1353.09,"body":"want to invest behind it, not"},{"speaker":"Lance Baldo","startTime":1349.61,"endTime":1353.09,"body":"just with financial resources,"},{"speaker":"Lance Baldo","startTime":1353.3,"endTime":1357.2,"body":"but hopefully also great people"},{"speaker":"Lance Baldo","startTime":1353.3,"endTime":1357.2,"body":"around the world as well. We're"},{"speaker":"Lance Baldo","startTime":1357.2,"endTime":1360.32,"body":"confident that we could"},{"speaker":"Lance Baldo","startTime":1357.2,"endTime":1360.32,"body":"commercialize this alone in the"},{"speaker":"Lance Baldo","startTime":1360.32,"endTime":1362.87,"body":"U.S. and some of the larger"},{"speaker":"Lance Baldo","startTime":1360.32,"endTime":1362.87,"body":"markets, particularly in Europe."},{"speaker":"Lance Baldo","startTime":1363.14,"endTime":1366.59,"body":"But beyond that, John, most"},{"speaker":"Lance Baldo","startTime":1363.14,"endTime":1366.59,"body":"companies our size just don't"},{"speaker":"Lance Baldo","startTime":1366.59,"endTime":1368.78,"body":"build that infrastructure—at"},{"speaker":"Lance Baldo","startTime":1366.59,"endTime":1368.78,"body":"least not for the first product."},{"speaker":"Lance Baldo","startTime":1368.78,"endTime":1370.79,"body":"We don't build that"},{"speaker":"Lance Baldo","startTime":1368.78,"endTime":1370.79,"body":"infrastructure, so that's what a"},{"speaker":"Lance Baldo","startTime":1370.79,"endTime":1374.81,"body":"good partner looks like as well."},{"speaker":"Lance Baldo","startTime":1370.79,"endTime":1374.81,"body":"And the other area where I'd say"},{"speaker":"we already have great partners","startTime":1375.35,"endTime":1379.64,"body":"the clinical community in"},{"speaker":"we already have great partners","startTime":1379.64,"endTime":1382.67,"body":"inherited retinal diseases,"},{"speaker":"we already have great partners","startTime":1379.64,"endTime":1382.67,"body":"which is the category of disease"},{"speaker":"we already have great partners","startTime":1382.67,"endTime":1385.79,"body":"that this fits into, absolutely"},{"speaker":"we already have great partners","startTime":1382.67,"endTime":1385.79,"body":"amazing. Everything from the"},{"speaker":"we already have great partners","startTime":1385.79,"endTime":1390.35,"body":"advocacy groups to the motivated"},{"speaker":"we already have great partners","startTime":1385.79,"endTime":1390.35,"body":"clinicians to the sites that"},{"speaker":"we already have great partners","startTime":1390.35,"endTime":1393.44,"body":"support our studies—they've been"},{"speaker":"we already have great partners","startTime":1390.35,"endTime":1393.44,"body":"amazing partners. This study was"},{"speaker":"we already have great partners","startTime":1393.44,"endTime":1396.83,"body":"enrolled in about 14 months, and"},{"speaker":"we already have great partners","startTime":1393.44,"endTime":1396.83,"body":"that might sound like a long"},{"speaker":"we already have great partners","startTime":1396.83,"endTime":1400.64,"body":"time for the uninitiated, but"},{"speaker":"we already have great partners","startTime":1396.83,"endTime":1400.64,"body":"enrolling a rare disease study"},{"speaker":"we already have great partners","startTime":1400.67,"endTime":1404.66,"body":"in about 14 months is nothing"},{"speaker":"we already have great partners","startTime":1400.67,"endTime":1404.66,"body":"short of magnificent, and we"},{"speaker":"we already have great partners","startTime":1404.66,"endTime":1408.05,"body":"couldn't have done that alone."},{"speaker":"we already have great partners","startTime":1404.66,"endTime":1408.05,"body":"It took the commitment of all of"},{"speaker":"we already have great partners","startTime":1408.05,"endTime":1412.07,"body":"the ecosystem around us to help"},{"speaker":"we already have great partners","startTime":1408.05,"endTime":1412.07,"body":"us get that done, and so we just"},{"speaker":"we already have great partners","startTime":1412.07,"endTime":1414.71,"body":"want to give back now, hopefully"},{"speaker":"we already have great partners","startTime":1412.07,"endTime":1414.71,"body":"with positive data, and then"},{"speaker":"we already have great partners","startTime":1414.71,"endTime":1416.69,"body":"with a medicine that's going to"},{"speaker":"we already have great partners","startTime":1414.71,"endTime":1416.69,"body":"help lots of people."},{"speaker":"John Simboli","startTime":1417.32,"endTime":1419.33,"body":"Thanks for"},{"speaker":"John Simboli","startTime":1417.32,"endTime":1419.33,"body":"speaking with me today, Lance."},{"speaker":"Lance Baldo","startTime":1419.39,"endTime":1499.58,"body":"I really enjoyed"},{"speaker":"Lance Baldo","startTime":1419.39,"endTime":1499.58,"body":"it. Thank you so much."},{"speaker":"John Simboli","startTime":1545.29,"endTime":1552.16,"body":"BioBoss is brought"},{"speaker":"John Simboli","startTime":1545.29,"endTime":1552.16,"body":"to you by Wyant Simboli, a"},{"speaker":"John Simboli","startTime":1552.16,"endTime":1555.73,"body":"strategic branding firm focused"},{"speaker":"John Simboli","startTime":1552.16,"endTime":1555.73,"body":"on helping life sciences"},{"speaker":"John Simboli","startTime":1555.73,"endTime":1559.54,"body":"companies advance. We partner"},{"speaker":"John Simboli","startTime":1555.73,"endTime":1559.54,"body":"with companies to define their"},{"speaker":"John Simboli","startTime":1559.54,"endTime":1564.55,"body":"story, structure their brand and"},{"speaker":"John Simboli","startTime":1559.54,"endTime":1564.55,"body":"inspire their audience. Visit"},{"speaker":"John Simboli","startTime":1564.55,"endTime":1568.03,"body":"wyantsimboli.com for more"},{"speaker":"John Simboli","startTime":1564.55,"endTime":1568.03,"body":"information."}]}