How the Endometrium's Interview Process Affects your Fertility: Conversation with Dr. Nick Macklon

Making Sense of Pregnancy: What Experts Want you To Know About Your Body

Making Sense of Pregnancy: What Experts Want you To Know About Your Body
How the Endometrium's Interview Process Affects your Fertility: Conversation with Dr. Nick Macklon
Feb 05, 2025 Season 1 Episode 11
Paulette Kamenecka

You may not have given much thought to the lining of your uterus, aka your endometrium; but it is a super important workhorse when it comes to pregnancy, and one that, it turns out, has a voice. The old story used to be that the endometrium is this passive, patient group of cells waiting to give any embryo it glimpsed a warm, safe harbor to grow. Today's guest shares the updated story: the endometrium as selective screener, interviewing the embryo--by assessing its chemical signals-- accepting and investing in the embryos it thinks are viable, and rejecting the rest.

Nick Macklon's published work can be found here: https://pubmed.ncbi.nlm.nih.gov/?term=nick+macklon&sort=date 

Uterine Selection of Human Embryos at Implantation: https://pmc.ncbi.nlm.nih.gov/articles/PMC3915549/

Dr. Macklon's work at the London Women's Clinic, Kind IVF