Aubrey De Grey - Longevity Escape Velocity - 7 pillars of immortality

The 7 Pillars of Longevity Escape Velocity – How Close Are We?

Longevity Escape Velocity (LEV) is when medical advancements extend lifespan faster than we age, effectively halting aging. But how close are we? In this video, we break down the seven pillars of longevity, how far we’ve come, and AI’s role—both its current limits and its potential to accelerate breakthroughs.

The 7 Pillars & AI’s Role

🧬 1. Cell Loss & Tissue Atrophy (60% solved, 15 years to go)
 • Problem: Some cells (like heart and brain) don’t regenerate, causing tissue decline.
 • Progress: Stem cell therapies are advancing rapidly.
 • AI’s Role: High – AI helps optimize cell growth, regenerative medicine, and personalized stem cell treatments.

🧪 2. Extracellular Junk (Amyloids & Plaques) (50% solved, 18 years to go)
 • Problem: Toxic protein buildup (like Alzheimer’s plaques) clogs tissues.
 • Progress: Beta-amyloid immunotherapies show promise.
 • AI’s Role: High – AI speeds up drug discovery, diagnostics, and treatment development.

🔬 3. Intracellular Junk (Lysosomal Waste) (40% solved, 20 years to go)
 • Problem: Cells accumulate waste they can’t break down.
 • Progress: Senolytics and enzyme-based therapies in early research.
 • AI’s Role: Medium – AI helps simulate cleanup processes and design new enzyme-based treatments.

🧿 4. DNA Mutations & Cancer (70% solved, 12 years to go)
 • Problem: DNA damage causes cancer, a leading cause of death.
 • Progress: CRISPR, CAR-T therapy, and early cancer vaccines.
 • AI’s Role: High – AI improves early detection, drug discovery, and personalized medicine.

⚡ 5. Mitochondrial Dysfunction (30% solved, 22 years to go)
 • Problem: Mitochondria power our cells, but mutations lead to energy decline.
 • Progress: Early work on mitochondrial repair and transplants.
 • AI’s Role: Medium – AI models mitochondrial interactions but can’t yet provide direct solutions.

🦠 6. Zombie Cells (Cell Senescence) (70% solved, 5-10 years to go)
 • Problem: Aging cells refuse to die, releasing toxic signals.
 • Progress: Senolytics are in human trials and showing success.
 • AI’s Role: High – AI accelerates drug discovery and personalized senolytic therapies.

🩸 7. Crosslinks & Tissue Stiffening (20% solved, 25-30 years to go)
 • Problem: Proteins bind together over time, making tissues stiff and brittle.
 • Progress: Glucosepane crosslink research is ongoing.
 • AI’s Role: Moderate – AI is helping identify enzymes to break crosslinks, but no treatment exists yet.

🧠 AI’s Role – How Much Will It Help?

AI is already accelerating research, but it can’t solve aging alone—yet. The real shift could come with AGI (Artificial General Intelligence).
 • Short term (5-10 years): AI speeds up drug discovery, clinical trials, and personalized medicine.
 • Long term (AGI-level AI): Future AI could model biologi

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Chapters

• 14:48 [Ad] Digital Disruption with Geoff Nielson
• 15:27 (Cont.) Aubrey De Grey - Longevity Escape Velocity - 7 pillars of immortality
• 24:56 [Ad] Everyday AI: Your daily guide to grown with Generative AI
• 25:45 (Cont.) Aubrey De Grey - Longevity Escape Velocity - 7 pillars of immortality