Rotations 2.0 Ep. 30 Testosterone Deficiency

Episode 30 Testosterone Deficiency

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Flying Through the Valley an Epical Trailer

Courtesy of Pixabay under Creative Commons non-commercial use.

Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

Answers for Episode 29 Gestational Diabetes

Question 1: 

 A 32-year-old Hispanic woman, G3P2, presents for her 28-week prenatal visit. Her 1-hour 50-g glucose challenge test is elevated, and a follow-up 3-hour 100-g oral glucose tolerance test confirms gestational diabetes mellitus (GDM). She is otherwise healthy, with a BMI of 33 kg/m². She asks whether her condition will resolve after delivery.

Which of the following best explains the underlying pathophysiology of her condition?

B. Chronic β-cell dysfunction unmasked by pregnancy

Question 2: 

A 29-year-old woman with a history of GDM is enrolled in a longitudinal study. Her disposition index (DI) is measured annually. Over 5 years, her DI steadily declines, although her fasting glucose remains within the normal range. Which of the following best describes the clinical significance of a declining disposition index in this patient

 C. It reflects progressive β-cell failure and precedes hyperglycemia

Question 3: 

A randomized controlled trial evaluates the effect of troglitazone in Hispanic women with prior GDM. Participants are stratified by changes in insulin sensitivity and insulin secretion after 3 months of treatment. One group shows a 50% reduction in insulin output and a 0% annual incidence of diabetes. Which of the following best explains the protective effect observed in this group?

B. Reduced β-cell secretory load due to improved insulin sensitivity

Paper for next week:

Andrea Giustina, et. al., Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows Endocr Rev, 2024 Apr 27;45(5):625–654. 

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