Rotations 2.0 Episode 47 Fibromyalgia

Episode 47 Fibromyalgia 

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Beats Through the Ashes by Alex Grohl

Courtesy of Pixabay under Creative Commons non-commercial use.

Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

 Answers for Episode 46 Gout

Question 1: Pathophysiology and Molecular Mechanisms

A 58-year-old male presents with recurrent gout flares. Genetic testing reveals a mutation in the NFAT5 gene. Based on recent findings, which of the following best describes the role of NFAT5 in gout pathogenesis?

C. NFAT5 enhances uric acid production through a feedback loop involving aldose reductase

Question 2: Diagnostic Imaging in Gout

According to the 2023 EULAR recommendations, which imaging modality is most effective for both diagnosing gout and monitoring crystal deposition and inflammation?

C. Dual-Energy Computed Tomography (DECT)

Question 3: Therapeutic Innovations

A new oral drug, dapansutrile (OLT1177), is being evaluated in Phase II/III trials for gout. What is its primary mechanism of action?

C. Selective inhibition of the NLRP3 inflammasome

Paper for Next Week: 

Fiona Kirkham-Wilson, Elaine Dennison1, Osteoporosis and Rheumatoid Arthritis: A Review of Current Understanding and Practice, British Journal of Hospital Medicine, 2024 Nov 30;85(11):1-11.

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