Rotations 2.0 Episode 71 Squamous Cell Carcinoma

Episode 71 Squamous Cell Carcinoma

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Fragile Beauty by Alex Grohl

Courtesy of Pixabay under Creative Commons non-commercial use.

Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

Answers for Episode 70 Basal Cell Carcinoma 

Question 1 

A 72-year-old patient presents with a 0.8-cm pearly papule with telangiectasias on the nasal ala that intermittently bleeds. A shave biopsy confirms basal cell carcinoma. Which risk category best applies to this lesion based on NCCN high-risk features summarized in the article?

B. High-risk basal cell carcinoma

Question 2 

A 66-year-old patient has metastatic basal cell carcinoma (mBCC) and is started on vismodegib, a Hedgehog pathway inhibitor. Which of the following best matches the outcomes reported in the article from the ERIVANCE BCC trial for patients with mBCC?

C. ORR 48%, median PFS 9.5 months, OS ~33 months

Question 3 

A patient with advanced BCC has progressed after a Hedgehog pathway inhibitor and is being considered for chemotherapy. According to the article, which regimen corresponds to a retrospective study reporting a partial response rate of 43% and median PFS of 6 months in advanced BCC?

D. Cisplatin 50 mg/m² IV on days 1 and 8 + cyclophosphamide 600 mg/m² IV 

van Zuuren, Esther J., Bernd W. M. Arents, Mirelle M. D. van der Linden, Sofieke Vermeulen, Zbys Fedorowicz, and Jerry Tan. “Rosacea: New Concepts in Classification and Treatment.” American Journal of Clinical Dermatology 22 (2021): 457–465. https://doi.org/10.1007/s40257-021-00595-7. 

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