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Can polyethylene glycol (PEG 3350, Miralax) affect the absorption of other medications?

In this BONUS mailbag episode of Rumor vs Truth, we answer a listener question about whether polyethylene glycol (PEG 3350) should be separated from other medications and, if so, by how long. Hosts Don Weinberger, PharmD and Steve Small, PharmD break down what the evidence actually shows about laxatives, intestinal transit time, and medication absorption.

Together, they discuss:

• Can PEG 3350 reduce the absorption of certain medications?
• Which medications might warrant extra caution when taken with PEG 3350?
• When spacing PEG 3350 doses may be reasonable...and when it may be unnecessary
• Practical counseling tips to balance adherence with potential interaction concerns

No CE credit is available for this bonus episode.
Want the full breakdown? CE credit is available for our full episode on laxatives.

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🎧 Related Episode (CE Available)

• Rumor vs Truth: Laxatives
  (Effective… or Hard Pass?)
  🎧Listen: https://rumorvstruth.buzzsprout.com/episodes/19520800
  ▶️ Watch: https://youtu.be/o3GlBngiaag 

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TRC Healthcare Editor Hosts

• Steve Small, PharmD, BCPS, BCPPS, BCCCP, CNSC
• Don Weinberger, PharmD, PMSP

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Clinical Resources:  

• FAQ: Management of Constipation

🏷️ Our listeners can get 10% off a new or upgraded subscription with code rvt1026 at checkout. 

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Send us Fan Mail

Email us: rumorvstruth@trchealthcare.com

The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

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