Sulfa Allergy: What Drugs to Avoid (and What’s Usually Safe)

This Is Why with Dr. Busti

This Is Why with Dr. Busti
Sulfa Allergy: What Drugs to Avoid (and What’s Usually Safe)
Dec 26, 2025
Anthony Busti, MD, PharmD, MSc, FNLA, FAHA

Sulfa allergy is one of the most commonly reported drug allergies (often cited around ~6% of patients), and it frequently leads clinicians to avoid entire medication classes—sometimes unnecessarily. In this lecture from This is Why, Dr. Busti will break down what drugs to avoid with a sulfa allergy (and what’s usually safe) by focusing on the “why”: the chemical features that drive true sulfonamide allergy risk and what that means for real-world prescribing.


You’ll learn how to:

- Identify what makes a drug a “sulfonamide”

- Distinguish antimicrobial vs non-antimicrobial sulfonamides

- Understand the structural features linked to higher allergy risk (why Bactrim is different)

- Apply practical guidance for patients with a reported sulfa allergy

- Avoid unnecessary “all-or-nothing” medication exclusions while still prioritizing safety


The goal = make medical education easy and clinically relevant.


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#SulfaAllergy #SulfonamideAllergy #Bactrim #SulfaCrossReactivity #drbusti


Disclaimer:

This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

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