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The Learning Corner
Vitamin D & Other Nutrients
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Deficiency Theory: When we are deficient in something we have symptoms or a disease that shows up. It's that simple.
Our Genes Lead the Way:
Low to moderate penetrance SNPs associated with vitamin D deficiency include variants in the VDR gene, CYP2R1 gene, GC gene. These SNPs can affect vitamin D receptor function, hydroxylation, binding protein levels, and enzyme activities involved in vitamin D metabolism. Additionally, some SNPs may have a positive effect on vitamin D status, such as variants in the GC gene, which can increase vitamin D-binding protein levels and enzyme activity, respectively.
Nutrient deficiencies, beyond vitamin D, can also lead to various diseases and chronic or acute illnesses. For example, vitamin B12 deficiency can cause anemia and neurological problems, while iron deficiency can lead to anemia and impaired cognitive function. Other nutrient deficiencies, such as vitamin A, vitamin C, folate, iodine, zinc, magnesium, and calcium, can result in conditions like night blindness, scurvy, neural tube defects, goiter, impaired immune function, muscle cramps, and osteoporosis. Low to moderate penetrance SNPs associated with these deficiencies include variants in genes like FUT2, MTRR, HFE, SLC23A1, SLC23A2, MTHFR, and TRPM6. These SNPs can affect nutrient absorption, transport, metabolism, and receptor function, contributing to the development of deficiency-related conditions.
The relationship between nutrient deficiencies and genetic variants is complex and influenced by various factors, including diet, sun exposure, and overall health status. While some SNPs have a low to moderate penetrance and may only slightly increase the risk of deficiency or related conditions, others may have a more significant impact. Genetic testing can help identify these variants, but personalized management strategies should be developed in consultation with a healthcare provider. Addressing nutrient deficiencies often involves dietary changes, supplements, and lifestyle modifications tailored to the individual's genetic profile and health needs.
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