Members of Technical Staff

Did Peptides Fall Off? with Max Marchione

Jayden Clark

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0:00 | 23:49

In today's extra I caught up with @maxmarchione to get a vibe check on peptides (they kind of fell off), get the FDA peptide panel update and talk about each other's stacks and skincare and such.

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Height is going to be solved

SPEAKER_00

Well that's a good way to start this, talking about our height issues. I mean, I'll speak to my fucking self.

SPEAKER_02

It's gonna be solvable, I think, in the next fifteen years. Yeah. We'll be able to unfuse growth plates, um, take growth helmet or something and grow. Um, interesting. I think I think definitely in the next thirty years, I think potentially in the next fifteen years. Yeah. Uh which is gonna be really interesting because you're gonna lose all your ambition.

SPEAKER_00

Exactly. Yeah, what do you think I'm compensating for? What do you think I'm compensating for you know, like like the way that I look at what I'm doing?

SPEAKER_01

All your humour disappeared, all your muscles are gone.

SPEAKER_00

My aura's just lost. I can just compensate for that. I mean, you know, they're solving this in Turkey, but they're doing it the kind of the way in which never allows you to deadlift ever again in your life.

SPEAKER_01

Yeah, I know. Guess what? Smash, smash your your tibia tibias, smash your fingers. And and pull the makes it, yeah, anyway.

SPEAKER_00

Um, yeah, yeah. I mean, it wasn't wasn't um wasn't on my topic list today.

SPEAKER_02

So if Jaden tells you that he's no longer deadlifting, you know why.

SPEAKER_01

I can't deadlift anymore.

SPEAKER_00

Yeah, I've actually I've actually never I've never been a joke in my life.

SPEAKER_01

I got into a car crash.

SPEAKER_00

Yeah, exactly, exactly. But that would be the higher aura version. Um, but no, I I like deadlifting too much. And um, I don't know, you know. I I like to joke a lot about my height, but I I can't say that my height has really prevented me from doing much in my life other than being good at some sports.

SPEAKER_02

I gave ChatGBT my bench numbers, my deadlift numbers, and it asked me if I actually had them right, because it's like, no, your bench press wouldn't be this high relative to your deadlift. Let's go check the numbers.

SPEAKER_00

I was about to say, let's go. Oh, hang on a second. Yeah, yeah, yeah, yeah. It happens, it happens. I think you know we all we all have our strong points. We all have our strong points, and that is okay. I mean, I think in my powerlifting days, it would have been the same, you know, my deadlift was way above everything else. Um, but now the only one that I care about is bench press. Yeah, you know, like as I as I keep telling people, as soon as I can bench 315, I'm convinced that my girlfriend will just instantly marry me. Yeah. That's how that works. That is how that works, and so I will I'll I'll keep that in mind. I'll keep that in mind. What I really wanted to get into today though, um, is that I

Vibe check on peptides. Have they fallen off?

SPEAKER_00

think, you know, the the the news, it travels pretty fast at the moment. And I think there was, there was, well one, I I don't think, I know there was a lot of peptide stuff that was missed. But first, before we get into some of this FDA advisory panel stuff, I want to just get like a general vibe check because to me it feels like now that the past year has sort of gone and done its thing, you know, I'm thinking back to, you know, if I think of it as like a timeline thing, like I started tweeting about this in July last year, July 4. And then New York publications starting started to catch on to this towards the end of last year, the beginning of this year. And then there was, you know, I mean, I mean, we various appearances, talking to Martin Schrelli, of course. I'm sort of just thinking about this timeline. It's been a whole year now. And I'm I'm wondering what the vibe check is now. Are people still talking to you about it a lot? Is this just kind of like mainstream now? So, you know, the the the peptide posts don't go as viral. I mean, we've got peptide parties, tasting parties and shit. Um I don't know. What's a what's a vibe check generally from you?

SPEAKER_02

So look, I think the peptide theme is gonna be structural because these things have fundamentally changed people's lives and will likely continue to. Um and that means that even if there's less hype, the structural theme is here to stay. Yeah. Similar GLP1s, right? 200 what, 21, 22, lots of hype, faded in 23, 24, back again with REDA, 25, 26. Um, it's gonna be true with peptides. Yeah. But right now, um, there's renewed interest clinically, um, in a more sophisticated sense, because the FDA kind of PCAC hearing happened. Yeah. An advisory committee gave advice to the FDA on how it should classify, I think it was seven peptides or eight peptides. Yeah, seven. Um the kind of uh high the the the like kind of mysterious hype around peptides has died down.

SPEAKER_03

Yeah.

SPEAKER_02

But I think there's this time where peptides are a meme. Using the word peptide would drive virality. Yes. Now there's more like measured interest. I think people are legitimately curious. I think even doctors and kind of researchers now are having to give this theme weight. Yep. In the early days, there was this broad skepticism of no, this is all pseudoscience. Yeah. Now even the peptide skeptics, I think, are saying, oh, actually, maybe there's something here. Totally. And uh I think what the the the turning point moment is going to be FDA um legalization when when that happens.

SPEAKER_00

For sure, for sure.

What happened with the FDA peptide panel

SPEAKER_00

I mean, I think it's a it's a good trend to actually get into the the FDA panel. So this was last week, right? Uh and it was seven peptides that were voted on. Six out of the seven were voted yes. And so I can't remember, I think I actually have a post here, because I can't remember the exact ones off the top of my head. Oh, here they are. So there was BPC157, KPV, TB500, Mot C. That's my one. Never taken it, uh, but seems pretty relevant to me. Uh Epitallon, Cimax, and uh Amedolitide. I've actually I've never heard of the last one, but that would that A Medolitite was the one that was voted no on. This is according to Hymns House, which of course is the account that's been following this very, very closely. Now, of course, when I was actually looking into this today, um, there actually weren't that many accounts that properly commented on it. And I was very reluctant to actually include a bunch of accounts that had commented on it because there was always some sort of like um, let's just say I don't that basically every account that commented on it were had like, oh, and here's where you can get them. Totally.

SPEAKER_03

Yeah, totally.

SPEAKER_00

I didn't want to I didn't really want to include them in the show run, for better or for words. But thoughts generally, thoughts generally, uh FDA advisory, of course, not to be confused with the FDA itself. It'd be probably a good distinction to start.

SPEAKER_02

Yeah, totally. Well, I think this has been a long time coming, right? The American people want peptides. Survey data shows that uh this is not a blue or red issue. Like people on both sides of the aisle, on average, want peptides. Um I think the reason why is enough people have tried them or seen people who have tried them. Yeah. I think clinicians who have been practicing with peptides for years want peptides because it makes it easier for them to drive outcomes with their patients. Um the panel, uh the PCAT committee was really interesting. Where all the people who were pro-peptide were clinicians who use them. Yes, right. Uh not clinicians who make money from them, but clinicians who have seen their effects in patients. The people who were anti-peptide were uh researchers, scholars, folks who maybe just started hearing about the peptide craze six to twelve months ago.

SPEAKER_03

Yeah.

SPEAKER_02

And I think that's interesting. I always pay attention to who's in the arena who's a practitioner versus who's a theorist.

SPEAKER_03

Yeah.

SPEAKER_02

Um there's an interesting question on timeline. Like when this was a uh suggestion that the PCAC committee made to the FDA. What is the timeline for actual approval if that happens? Yeah. My guess is it's going to come before November elections. Yeah. So I think there's going to be a ruling or at least some sort of like preliminary ruling by the FDA in October, November-ish. And then I think that if we actually see legalization for compounding inclusion in the bulk substances list, I suspect that's going to happen around January, February.

SPEAKER_00

Wow. Yeah, that was that was going to be one of my questions. I think what could be interesting to get into here, I mean, first of all, even if I'm just going down this list, it could be useful to actually just go through the list and be like, okay, what does what does each one of these do? Right? Because again, six out of seven were voted yes on. Um one of them being BPC157, very popular. Of course, we've

What does BPC-157 and TB-500 do?

SPEAKER_00

talked about a bunch. Healing peptide. I mean, you want to add anything else to that one?

SPEAKER_02

Yeah, BPC157 and TB500 are often looped together, grouped together, often taken together, used broadly for healing. Yeah. Um, sometimes taken orally for healing of the gut, the intestinal uh uh lining. Uh sometimes taken subcutaneously via injection, either in the stomach or locally at the side of an injury for faster injury repair. Um think torn ligaments, torn muscles, uh torn biceps from oral curls, God forbid, knock on wood somewhere, some wood. And uh sometimes taken for pain as well. Yes. So I know um I think two groups at the moment performing clinical studies for BBC 157 and pain, which is an easier thing to study because the kind of end point that you measure for pain is is is a self-report. And you can do that relative to placebo,

What does MOTS-c do?

SPEAKER_02

right? Um so there's BBC 157. MOTC on the list is a kind of mitochondrial peptide. Yep. Um people say that it could uh uh support longevity, can support energy levels, can increase HRV, can make people uh uh cells more efficient. Right. The mitochondria people say it's like the powerhouse of the cell. Yeah. As you might remember from high school biology class. Um finally, finally using something that I learned. Um

Epitalon for sleep

SPEAKER_02

epitalon is one of the bioregulators that people are using to improve sleep and their circadian rhythm. Um I've taken this orally, and I find it's one of the few things that uh I notice has an effect on sleep.

SPEAKER_00

Yeah, you you prefer it over something like melatonin, right?

SPEAKER_02

No, yeah, I I think it's probably a little bit um I I I I I personally find the effect is far more noticeable. There's less grogginess than melatonin. It doesn't develop the same kind of habituation, at least we don't believe it does relative to melatonin. And I've tried everything for sleep, right? I've tried every supplement under the sun. Yep. Um epitalin is kind of up there on my list.

Semax for cognition

SPEAKER_02

And then CMAX is primarily taken for cognition, I believe it was invented in Russia perhaps, often taken as a nasal spray rather than an injection. Yeah. And people say it helps them with focus, mental clarity. Um, yeah.

SPEAKER_00

Okay. Yeah, what's um, I guess my other my other question, right? Because obviously you mentioned that BBC 157 and TB500 are taken together most of the time. What are what are the differences between those two compounds just generally? Um why would you take them together as opposed to not together?

SPEAKER_02

Yeah, I don't know mechanistically um what the difference is. I think the reason they're taken together is that they target the same thing, right? And because they target the same thing and they likely have different mechanisms of action, people are like, we have a certain goal. You can achieve that goal more effectively by using two things um which are going after the the kind of same same endpoint.

SPEAKER_00

Totally, totally. And then the other couple on that list, one that was voted yes is KPV. I've never heard of KPV in my life. I don't even know what that is.

SPEAKER_02

Yeah, also used for healing. There are whole formulations, some people are taking it for for gut health. Yeah. Um thought of in a similar category to BPC and TB500. Interesting. And then the other one, the one that was voted no on, uh is maybe that's one name for uh D D S I P Delta sleep inducing peptide. Right. Um I I haven't tried it. I don't know many people who have. Some of the people who have tried it, I know, speak quite highly about it. Some people say, oh, in my aura ring, it kind of shows a big improvement in sleep. Oh, interesting. And some people who who have tried it say it doesn't do anything. Yep. Um I don't have an understanding of what human data and animal data we have on DSA. Um I don't think it's been around for quite as long as the others, or it's not as broadly used. So I suspect the like anecdotal data and clinical data is more sparse.

SPEAKER_00

Totally, totally. And I guess um, you know, to uh to for my particular interest, none of the growth hormone secretogogs made it onto that list. The ones that could be thought of as perhaps maybe inducing muscle growth.

SPEAKER_02

Well, well, we already have two um FDA approved uh or at least bulk substances approved growth hormone secretogogs. Yeah. Right? We have semorelin and tesimerellin. Of course, yes. Um and m my sense is given that we have two growth hormone secretogogs as well that have been through like phase three clinical trials, there's a large there's likely not a big incentive for the FDA to also look at C, J C and Ipermorelin. Sure.

SPEAKER_00

Makes sense to me, makes sense to me, because naturally the only thing that matters to me is what substance can make my arms bigger without giving me cystic acne. Or like, you know, me losing my hair.

SPEAKER_01

The list is limited.

SPEAKER_00

Yes, like creatine. Yeah, yeah. Oh, you know, uh already on already on 10 grams of that a day. So, you know, um, well, double the recommended,

How much creatine I take and creatine for sleep

SPEAKER_00

you know, five grams, but seems to work for me. I will take I will take the uh minimal gains right from that extra five grams. I'll take everything that I can get. And if I function okay and um my stomach and my liver feels okay, then you know, big fan, big fan.

SPEAKER_02

Well, I think some of the studies, and I have to look into this, but I think some of the studies on creatine for things like Alzheimer's and cognition are increasing the dose to 15 to 20 milligrams a day. I could be wrong, don't quote me, but it's just the case. There's also this like trend right now of um when you have a a night of very little sleep, taking 20 to 30 milligrams of creatine the next day.

SPEAKER_03

Yep.

SPEAKER_02

Um personally I don't find it as much for me. Um there are some people I know who swear by it, and then there are some people I know who say it has them on the toilet all day.

SPEAKER_00

So yeah, well my thing is always like if I've ever taken, right, right, because because now I take, you know, 10, not five. If I ever accidentally double up, right, because I mean there's nothing worse than getting all the way through your day and realizing, oh my god, I've forgotten to take my creatine, right? Just like having the realization and then doubling up and taking 20 instead of 10. Uh, my thing is the dehydration. My thing is the dehydration. Uh you've got to drink so much water if you're taking 20, right? Yeah. And I saw studies that would say, oh, you should actually take, you know, upwards of like 70, you know, to try and cancel out the effects of sleep. Yes. Insane. Um and so like you start getting into uh some interesting trade-offs, really just with how much water you need to take just to stay alive for that fucking day.

SPEAKER_02

Yeah, I almost wonder like, uh, does um uh improving energy levels just come down to drinking more water? Probably not really. I do think creatine's having an effect, but that that might uh be supportive as well.

SPEAKER_00

Totally, totally. And you know, my favourite peptide of all time, creatine. So uh there's a reason why uh I am called that uh and it's not just because I was like 22 at the time making my silly stupid little Twitter account. Yeah. I thought it was funny.

SPEAKER_02

I think I actually think creatine might not be a peptide.

SPEAKER_00

You don't think so?

SPEAKER_02

I I I I I I forget, but I remember everyone says it's a peptide, and then I think I remember asking ChatGPT or something, and they're saying, no, it's not

Skincare

SPEAKER_02

actually a peptide. Who knows? I don't think it really matters. Um collagen's definitely a peptide. Creatine, I'm not so sure.

SPEAKER_00

Yeah, yeah, yeah, yep, yep. I mean sorry to break it to you. It's that would be incredibly unfortunate. I don't even think I I I think I only use um, you know, when the girlies get me to use collagen for my skin. That's when I'll use it. Yeah. I don't even think I don't actually think I have collagen in my skincare routine at the moment. It's just it's just tretinoin. Yeah.

SPEAKER_02

Okay, yeah, yeah.

SPEAKER_00

The the classic Yeah, there we go. Yeah, exactly, exactly. You know, I mean people people I mean I I don't want to, I don't want to um I don't want to toot my own horn uh too much here, although it is my own fucking show, so I guess I can say whatever the hell I want. But basically, I have gotten comments and I'm fishing really hard for this saying that my skin is glowing. It is glowing. It's glowing a little bit more.

SPEAKER_02

Thank you, thank you. It must be all the peptides, you know. Exactly.

SPEAKER_00

Do you take the do you take the copper one for your skin? No, you don't.

SPEAKER_02

I've tried it topically before. You can just buy it at Amazon like the ordinary sells it. Um I don't personally notice a difference. Yeah. Um, but I know some people swear by it. Yeah, interesting. Most of the people I know who swear by it take a prescription grade um topical one or they take the injection, and I haven't tried either of them.

SPEAKER_00

Yeah. Do you have a skincare routine? I'm I'm getting sort of sidetracked from what I want to do. But I'm I'm I'm curious.

SPEAKER_02

Yeah, I I I started uh moisturizing maybe a year ago.

SPEAKER_00

Oh yeah?

SPEAKER_02

So you know I'm getting getting old now. Um yeah, I I think I think like the there's like a set of ingredients that have studies to show that their effectiveness, right? You have certain B vitamins, you have nicinamide, you have um certain like topical peptides that can be applied. Yes. You have all the cleansers people use. And I think if you have a good cleanser and a good moisturizer, you end up ticking the boxes of most of those things.

SPEAKER_03

Yeah.

SPEAKER_02

And then the probably level above is adding some sort of uh serum, where like serum is either in the direction of peptide GHKCU, which is a kind of a copper peptide or tritinoin. And I think the reality is um the kind of copper peptides or the peptides are doing a similar thing to the the tritinoans of the world. So many people who take one probably don't need the other. For sure, for sure.

SPEAKER_00

And of course it's like, you know, I mean, obviously, uh I used to take prescription acne cream as a kid, and so my skin is pretty damn bulletproof to retinol. Like I can I can just rub this shit all over my face and I I will not peel at all. Like, in fact, I'll barely look dried. Yeah, I do I do use moisturizer, of course. Um, but yeah, no, my my skin has a particular tolerance to the to the prescription cream, so that's why I just ramp it up. Yeah.

SPEAKER_02

I know a lot of people who swear by Tredinola.

SPEAKER_00

Yeah, yeah. Yeah, yeah. So, you know, I mean it's just you know recent recent thing of mine in the last last few months.

SPEAKER_02

Yeah, and not medical advice. Ask your doctor.

SPEAKER_00

My doctor was Amazon pharmacy for that particular one. Uh, but no, no, no, I've like I said, I've I've I've taken retinols, uh used retinols for for years and again. Um uh as a teenager, I did ask my doctor. So, you know, that is that is the um just to quickly sort of wrap on the uh peptide panel, like there was one more question that I wanted to ask, um, and that was just the panel itself, because obviously, you know, to me, and there was some discussion about this, like obviously this seemed to be a pretty pro-peptide panel. Uh do you think there is any any sort of inherent bias because of that? Do you what like like uh yeah, I I guess would you have preferred there perhaps being, you know, slightly less biased in the panel itself? Or do you think it makes a difference at all?

SPEAKER_02

I think they tried to find people who had experience with peptides. Yeah. So users, like you mentioned, users as opposed to researchers. And the clinical observations that come from doctors practicing with them.

SPEAKER_03

Yeah.

SPEAKER_02

Um and uh if you want to not, if you want to have a panel that does not involve people using pep using peptides, you can be like, oh, it's a non-biased panel. Yeah. A bunch of researchers who discovered peptides six months ago.

SPEAKER_00

So it'll be back the other way on.

SPEAKER_02

So it's hard to say. There's always going to be arguments of is this biased, is this not biased? Typically, when someone has knowledge of a thing, there's someone involved in a thing. That's just like the the the reality, right? If someone believes in peptides, they probably use peptides.

SPEAKER_03

Yeah, yeah, yeah, yeah, yeah.

SPEAKER_02

Right? So it's really tricky to make these arguments, and I think there are people who could make arguments in either direction in this case.

SPEAKER_00

Totally, totally. I think the last thing, just to just to wrap on, completely sort of off the cuff. Um what's um what's

Max’s current stack

SPEAKER_00

what's been what's been sort of the the stack recently for for you? And this is gonna be, you know, I've asked about the skincare routine. Just generally, like what's the what's what's part of the routine? Again, like we we always talk about like the routines, you know, whether it be the workout routines, it's like, oh, you know, what are you hitting recently? Like, what's your shoulder day look like? We talk about the routines off camera. Um, but anything that you've been particularly getting up to in the last couple of months that might might have been different since, say, the last time we met.

SPEAKER_02

Yeah, so um microdosing to Zeppetide now. Um shit. Yeah, yeah. Um I find that I don't have as much appetite suppression, but I don't have the resting heart rate increases to as much of a degree.

SPEAKER_00

Yeah.

SPEAKER_02

Um I take such a low dose regardless. Of course. So I I don't think it makes a ton of a difference either way. Um is still something that that's like a regular thing with me. It does have a big impact on not getting sick, and um I travel a reasonable amount, I stress a lot, I probably don't sleep enough. So I had a lot of uh stress in the immune system, and I find that is useful.

SPEAKER_03

Yeah.

SPEAKER_02

I will do IV drips um when I'm getting sick or as needed. That typically means um NAD, quite a higher for that. And then sometimes like vitamin C, glutathione, B vitamins, vitamin D. Um supplements are like an interesting thing because I've I've always taken lots of supplements, but supplements uh are very hard to adhere to. Yeah, right? People hate opening lots of bottles in the morning. It's like a very trivial thing I've been doing is I just have a pair of supplements at the start of the week.

SPEAKER_03

Yeah.

SPEAKER_02

And kind of the morning stack at the moment is a broad spectrum multivitamin. Um A, B1, B2, B6, B9, B12, C, D, E, K1, K2, both forms of K2, and then like your minerals magnesium, sodium, potassium, chloride, boron, lithium, uh, etc. Um NaC, uh, which is kind of a precursor to glutathione, which people call like the master antioxidant. Sure, yeah. I mean upping um uh dosing of other antioxidants, things like lutein, asthaxanthin, um uh some of those uh kind of mitochondrial uh antioxidants. I don't notice a big benefit of them, so I might remove them from my stack.

SPEAKER_00

Yeah.

SPEAKER_02

Um uh going higher on like omega-3 dosing. Oh, interesting. Um my kind of omega-6 relative to omega-3 levels is still too high. Yeah. And I want to think about, I don't have the right uh stack for it yet, but I want to think about how to almost reset that. Yeah. And then I'm about to start um trying to do a a like detox stack. Basically, my levels of mercury are still too high, my levels of mold are still too high. Um, my exposure to like glyphosate and environmental pesticides is still too high. And every six months or so I'll do a pretty hardcore detox stack to try to reset.

SPEAKER_00

Oh, interesting, interesting. Yeah, I mean, gosh, I my I I I always think about my own stack. It's funny,

My own stack

SPEAKER_00

I take my own stack before I go to bed personally, because it's always like like zinc magnesium. I take my vitamin D for the day. Um, you know, after I got my uh blood test with superpower, I realized that I needed to supplement selenium for a little bit. Okay. And so so I've been supplementing selenium, which has been great. And what else? What else? Well, actually, I it's not not really uh it's something that I have to take, but zertec because I have chronic hives. Interesting. And so I have to I take a zertec every night. I've been taking a zertec every single night since I was like 12.

SPEAKER_02

Really interesting. So it's not necessarily great for your gut. I think there's like this interesting question of like, why do you have chronic chronic hives, right? Yeah. Is it mast, is it some sort of mast cell problem? Is it um because of some uh uh challenge with like your gut or your gut lining? Um it's hard to solve. So sometimes it's a food sensitivity, sometimes it's environmental sensitivity. Yeah. Um but I'd be so curious to see like two test results for you. One is like a broad spectrum allergy panel, what shows up. Yeah. And the second is um a gut microbiome test. Yep.

SPEAKER_00

It's probably what I'll have to do because I mean, you know, it's it's been a very, very easy thing to just kick the can down the road because again, 12 is like, oh, Zotec, not super expensive. Take one of them every single night, I'm never itchy again. Great.

SPEAKER_03

Yeah, yeah, yeah. Totally.

SPEAKER_00

But yeah, it's like like um I remember the doctor just telling me at the time, he's like, yep, your body just produces too much histamine. I was like, okay. If it why?

SPEAKER_02

It's like I mean, like I like, yeah, doctors love these band-aid solutions. Uh that's often how medicine is taught. Pharma loves medicine to be taught that way because they develop band-aids. Um, but the the kind of interesting question is always why. And histamine sensitivity is like surprisingly common. Yeah. More common now than it was maybe 50 years ago. Sure. Potentially, because of things that happen in our environment and things we're exposed to. Yeah. And um uh yeah, the the the why question I think is pretty important.

SPEAKER_00

Totally. Well, we'll get we'll get to the bottom of this, I think, next time we check in. Uh well. Yeah, we'll have to give you some tests. Yeah, yeah, exactly.

SPEAKER_02

Like we do allergies and gut and totally, totally set up.

SPEAKER_00

I'm down, I'm down because yeah, I've I've never bothered to look into it because I'm like, you're a cool band-aid. Yeah. Well, stay tuned for this. I think it's actually also a good place to wrap. Uh, just yet again, no, another another peptide, another stack up, stack update. Uh we need to do this every month, basically. And we have been doing this every month. So we'll see you guys again on the timeline. Real soon. Been listening to another episode of Members of Technical Stuff. I just sent it all in the fucking reverse. This is the I've I've absolutely lost my mind this week. Anyway, let me try this again. You've been listening to another episode of Members of Technical Staff. We'll see you on the timeline again real soon.