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The Incubator At The Bench
At the Bench is a podcast series produced by The Incubator and hosted by Dr. Elizabeth Crouch, Dr. David McCulley, and Dr. Misty Good. This series is dedicated to exploring the lives and work of neonatal physician scientists. Each episode features in depth conversations with neonatologists who have chosen careers rooted in discovery science, offering listeners a closer look at what it truly means to be “at the bench.” Through thoughtful discussion, the hosts explore how these clinicians found their path into research, the scientific questions that drive their work, and the challenges and rewards of balancing clinical care with life in the laboratory. The series provides insight, inspiration, and practical perspective for trainees, early career investigators, and anyone curious about the role of physician scientists in advancing neonatal care.
The Incubator At The Bench
#005 - Sex Differences in Neonatal Lung Injury (ft. Dr. Krithikia Lingappan)
In this episode of the Incubator, At the bench, we talk with Dr. Krithika Lingappan who is a neonatologist and physician-scientist at the Children’s Hospital of Philadelphia and the University of Pennsylvania. Join us as we hear what inspired Dr. Lingappan to build her cutting-edge research program investigating sex-specific differences in preterm lung disease. She explains that every cell in the lung shows sex bias, including epithelial cells, endothelial cells, and immune cells. She explores the role of the X and Y chromosomes in determining susceptibility to lung diseases and the ongoing research to understand the dosage of the X chromosome and genes on the Y chromosome. Dr. Lingappan also discusses the use of multi-omics approaches, such as single-cell RNA sequencing and spatial transcriptomics, to study lung development and disease. We are fortunate to learn from her experiences including finding mentorship, building a research career that addresses a common clinical question, and establishing and then moving a research group. Dr. Lingappan also discusses her work promoting neonatology physician-scientist career development. We are thrilled to bring you this inside look into what it takes to become a neonatology physician-scientist!