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The Incubator At The Bench
At the Bench is a podcast series produced by The Incubator and hosted by Dr. Elizabeth Crouch, Dr. David McCulley, and Dr. Misty Good. This series is dedicated to exploring the lives and work of neonatal physician scientists. Each episode features in depth conversations with neonatologists who have chosen careers rooted in discovery science, offering listeners a closer look at what it truly means to be “at the bench.” Through thoughtful discussion, the hosts explore how these clinicians found their path into research, the scientific questions that drive their work, and the challenges and rewards of balancing clinical care with life in the laboratory. The series provides insight, inspiration, and practical perspective for trainees, early career investigators, and anyone curious about the role of physician scientists in advancing neonatal care.
The Incubator At The Bench
#008 - From Skeptic to Scientist, A Conversation with Dr. Augusto Zani
In this episode of the Incubator: At the bench, we talk with, Dr. Augusto Zani, a pediatric surgeon scientist who discusses his work on fetal lung regeneration and the use of stem cell derivatives and extracellular vesicles for diagnostics and therapy. He shares his journey from surgical training to becoming a surgeon scientist and the challenges he faced along the way. Dr. Zani also explains his transition from studying necrotizing enterocolitis to congenital diaphragmatic hernia (CDH) and the unanswered questions in lung hypoplasia related to CDH. He highlights the importance of understanding the mechanisms behind these conditions and the potential of extracellular vesicles in promoting lung growth and regeneration. Dr. Augusto Zani discusses his research on congenital diaphragmatic hernia (CDH) and the potential use of extracellular vesicles (EVs) as a therapy. He also discusses the role of inflammation in CDH and how EVs have both regenerative and anti-inflammatory properties. Dr. Zani also mentions the potential use of EVs in other pediatric surgical conditions, such as gastroschisis and spina bifida. He concludes by sharing his excitement about moving his lab to St. Louis Children's Hospital in the U.S.