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Food, supplement, and medication interactions are more common—and more nuanced—than many clinicians realize.

Everyday foods and supplements can quietly alter drug effectiveness or safety - and often go unrecognized in practice. Grapefruit juice, orange, juice, and green tea extract are just a few examples that may have more clinical significance than expected.

In this episode, NatMed editors Jeff Langford, Andrea Stafford, and Kelly Daniels break down clinically relevant interactions using atorvastatin as a case study—and show how to apply a practical framework for identifying, interpreting, and managing these interactions at the point of care.

Questions we answer in this episode:

• Which common beverages, foods, and supplements interact with atorvastatin - and how do they affect the drug?
• How do interactions differ between increased drug levels (toxicity risk) vs reduced drug effectiveness?
• When should clinicians recommend avoidance vs timing adjustments vs monitoring?
• How can clinicians identify interactions patients don’t think to mention in routine conversations?

🏷️ Our listeners can get 10% off a new or upgraded subscription with code natmed1026 at checkout. 

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NatMed / TRC Healthcare Editor Hosts: 

• Jeff Langford PharmD, BCPS, BCCP (Managing Clinical Editor)
• Andrea Stafford, PharmD (Assistant Editor)
• Kelly Daniels, BA (News Editor & Associate Content Manager)

Guest:

• Cathi Dennehy, PharmD, FCSHP (Health Sciences Professor of Clinical Pharmacy, UCSF School of Pharmacy)

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CE Information:

This podcast is sourced from the NatMed June 2026 Newsletter. To claim CE credit, subscribers should read the newsletter and click “Take the CE Quiz” link to take the quiz. 

Claim Credit

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The clinical resources mentioned during the podcast are part of a subscription to NatMed: 

• 🌱 NatMed Pro
• 💊 TRC Healthcare
• Newsletter
• Interaction Checker
• Infographic
• Monograph: Grapefruit
• Monograph: Green Tea
• Monograph: Orange Juice

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The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

Natural Medicines: Evidence in Practice is a production of TRC Healthcare.