Migraines are complicated — and when patients are dealing with recurring symptoms, it’s no surprise many turn to natural medicines. From butterbur and CoQ10 to caffeine, these options are easy to find and frequently discussed, but the evidence and safety can vary widely depending on how they’re used.

In this episode, NatMed editors Jeff Langford, PharmD, BCPS, BCCP; Andrea Stafford, PharmD; and Kelly Daniels break down the evidence behind common natural medicines for migraines and discuss how clinicians can help patients match the right option to the right goal… prevention versus acute treatment, while setting realistic expectations at the point of care.

Questions we answer in this episode:

• What should clinicians know about butterbur, including effectiveness, PA‑free labeling, product quality, and safety concerns? 
• How long does coenzyme Q10 typically take to show benefit, and how should patients be counseled before starting it?
• When can caffeine play a helpful role in migraine treatment — and when might it backfire?

Throughout the episode, we discuss how dose, timing, and total intake can shape whether natural medicines work as expected — and why those details matter just as much as the ingredient itself. We also share practical counseling approaches pharmacists can use to keep conversations focused and useful when patients ask what’s worth trying for migraines, without defaulting to a one‑size‑fits‑all answer.

🏷️ Get 10% off a new or upgraded subscription with code natmed1026 at checkout. 

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NatMed / TRC Healthcare Editor Hosts: 

• Jeff Langford PharmD, BCPS, BCCP (Managing Clinical Editor)
• Andrea Stafford, PharmD (Assistant Editor)
• Kelly Daniels, BA (News Editor & Associate Content Manager)

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CE Information:

This podcast is sourced from the NatMed April 2026 Newsletter. To claim CE credit, subscribers should read the newsletter and click “Take the CE Quiz” link to take the quiz. 

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Clinical resources, part of a subscription to NatMed: 

• 🌱 NatMed Pro
• 💊 TRC Healthcare
• Newsletter
• Infographic
• Monograph: Butterbur
• Monograph: Coenzyme Q10
• Monograph: Caffeine
• Effectiveness by Condition Tool: Migraine Headache

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The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

Natural Medicines: Evidence in Practice is a production of TRC Healthcare.