#38 Peptides that Help PMOS (Previously Known as PCOS)

A landmark Lancet paper officially renames PCOS to PMOS: polyendocrine metabolic ovarian syndrome. That wording is a big deal, because it pulls the conversation away from “Do you have cysts?” and back to what so many of you have been trying to explain for years: this is about multiple hormones, blood sugar, inflammation, and a body that feels like it’s fighting you no matter how hard you try. 

Inside this episode, we talk through what “endocrine” actually means in real life: 

• thyroid, 
• cortisol, 
• vitamin D, 
• metabolism and blood sugar
• progesterone, estrogen, testosterone. 

We also dig into why liver function matters for hormone clearance, and how being told “here’s birth control” or “here’s metformin” can miss the bigger picture. 

If you’ve ever felt dismissed because your symptoms didn’t fit a neat checklist, the PMOS shift may feel like validation. 

Now that you understand what PMOS actually means and how to treat it, what are the peptides that match the treatment protocol? Peptide therapy can be one of the best options for individuals who suffer from symptoms from PMOS: 

• GLP-1/GIP (terzepatide) 
• Glutathione 
• MOTs-C

Finally, we answer the question people keep asking about GLP-1s and other peptides: “How long do I need to be on it?” and why microdosing long term can be a smart, normal choice when your body doesn’t make enough GLP-1 in the first place. 

If this helped you think differently about PMOS, subscribe, share the show with a friend, and leave a review so more people can find accurate peptide and women’s health information.

Want to connect more with the hosts? We'd love it! Connect with Jess at B2BwithJess.com/peptides or on Instagram @jessb.talkshealth. Grab your Blood Work & Peptides Mini Guide for free at drkylieburton.com. 

Ready to explore peptide therapy for yourself? Visit the company we recommend for pharmaceutical peptides and receive all the one-on-one support that comes included at drkylieburton.com

Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com

Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary.

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Transcript

SPEAKER_01 0:02

Peptides are powerful and often misunderstood. And here we are trying to change that one conversation at a time. I'm Dr. Kylie Burton. And I'm Jessica Brickie.

PCOS Officially Becomes PMOS

SPEAKER_00 0:15

This is Pep Talk, Peptides Unpacked. Science made simple, results made real. If you've listened to this podcast and you haven't shared it yet, please do and take it one step farther and leave a review so that more people can find this podcast and find the true information about this lovely topic we call peptides. A review and a share would be greatly appreciated as we continue to get more and more downloads each week, doubling our downloads, which means you guys are loving the podcast and we're grateful for that, which is why we are striving to bring you more episodes this summer rather than pushing pause and taking a step back. We're going to keep going. So welcome aboard. If you're new here, well, we drop an episode whenever we feel like it. And we've been doing that about two per week. Um, that's the pace we've been keeping at, as we can bring you more information, more guests, because the reality is we can't share this information fast enough. So if you've been digesting it, thank you. Please share. If you're new here, welcome aboard. Today's topic is something we've heard a lot in the news, where PCOS has now become PMOS. Jess tell us about it.

SPEAKER_01 1:40

This is big news. This is big news for women that have been dismissed for many years or even not even treated properly. But on May 12th of this year, 2026, if you're listening later on, there was a landmark paper that was published in the Lancet. And that is one of the most prestigious medical journals in the world. And they announced that after 14 years of global collaboration involving over 22,000 patients, researchers, and advocates across 56 different organizations, polycystic ovarian syndrome, PCOS, has been officially renamed and it is now called polyendocrine metabolic ovarian syndrome, P M O S. And when I read this, my first thought is how many women I know that have been told it is just simply a hormone issue and nothing more.

SPEAKER_00 2:39

And now with this new name, we understand this is an endocrine issue, it's so much more, and that's gonna change the poly, polyendocrine means multiple, multiple, endocrine. Mm-hmm.

SPEAKER_01 2:55

Yeah, so it's a little personal for me. So while I was never personally diagnosed with PCOS, when I was 19, and we're going back a few years, so I'm 50, currently 54, I'll be 55 this year. I was diagnosed with endometriosis. Not the same condition, but it was a really progressive doctor that did a surgery, found the scar tissue, and all of that. Um and along the way, I struggled still with my managing my symptoms, which was very difficult periods, painful periods, um, a lot of a lot of issues, to the point that there were days that I couldn't even sit because the pain was so incredible. And at the age of 23, I was told by another doctor to have a hysterectomy. That was the only way that I was gonna go with the case. I was gonna say, and you had kids? Yeah. 20. Can you imagine? I was 23, and this doctor said, Well, the only way you're gonna deal with this is to have a hysterectomy. I was so unbelievably dismissed by this doctor. Now, again, we didn't, we still probably don't know everything we should about endometriosis or PMOS, but the point is, is I went on to have three children. But through those early years in my 20s of trying to treat my endometriosis, I stumbled upon one way to self-treat my symptoms, which was the Atkins diet, which was all the rage back then. And that meant no, no carbs, no sugar, any at all. And when I was true to that, I had no symptoms. I felt my best, I had no pain, my periods were normal. Um, but it wasn't sustainable. Like having no carbs is not healthy. Which is why nobody's still on it. Right, exactly. So fast forward now, um, I would say, and probably in you in in your you're younger than me, and so you're you're more still in the childbearing years, you hear more and more women talking about having PCOS and and endometriosis. And it's gonna be a hard switch, by the way, to go from PCOS to PMOS. So used to saying that. Um, so it became more and more common that you were seeing this diagnosis, which one, because maybe we were better better at recognizing the symptoms and how to diagnose somebody accurately, but we didn't necessarily get better at treating women that have either condition. So when we look at the fact that all of these people, and that is a lot of people that were involved in this name change, have come together and said, hey, we've got it wrong. We need to change this name to something that is talking about the endocrine system because we told women that had this they didn't because they didn't have cysts. There is a ton of women that have dealt with for many years all of the symptoms of PCOS, with the exception of cysts, and because they didn't have that, they were dismissed as it's just your hormones are out of balance, or we'll control you by putting you on birth control. Um sorry, even sometimes just sorry.

SPEAKER_00 6:05

Yeah, several patients who came across my space had both. They had the endometriosis, the heavy, painful periods, and then they had the flip side of my endocrine system, my hormones, my everything is just whacked. And the only thing that they're gonna do for me is give me one metformin. That was the first step with all the side effects metformin came with, and then two, hormones. Yeah. So our hormones are a mess. Let's give you more hormones.

SPEAKER_01 6:36

Yeah, it's the craziest approach. You brought up something that I I was thinking about when I was writing notes to do this, and that is so I talked about my diagnosis of endometriosis at such a young age when nobody knew anything, and yet I have so many symptoms of the PCOS. Now I didn't have the acne, I didn't have the facial hair, but I had so many other things, and it was definitely controlled, all of it, by how I was nourishing my body. So I think back now, I'm like, gosh, I wonder if I did have both, but it was never diagnosed because I wasn't dealing with cysts. There were times I had some, but it wasn't like a big problem for me. So I the fact that I had some cyst, cystic activity in my young adult years, I think that I probably was one of those women that had both things, but nobody knew how to help me.

SPEAKER_00 7:30

Right. And in the same scenario, they can't lose weight, correct? They try everything under the sun, and the weight doesn't go off, it just keeps getting worse typically.

SPEAKER_01 7:42

There's a TV show that is on, um, and I'm I'm uh drawing a blank. It's uh the woman is a she's a she's a really heavy-set woman, she's a dancer, her name is Whitney, and I can't think of the name of this show on TLC, and she has PCOS, and she's been a big advocate for um large body women, women with PCOS, and all of the symptoms that come along with that. And you watch her over the years of this show really struggle with fighting her biology. I mean, she worked out like crazy, she was mindful of our food. And by the way, you should be able to go and have ice cream every now and again and not worry that you're your the scale went up 10 pounds because you ate one thing that isn't perfect.

SPEAKER_00 8:27

Yeah, they're doing the exercise, they're doing the lifestyle more than the skinny fat people are. Correct. And yet they're not looking the part.

SPEAKER_01 8:35

Right. Now, with endometriosis, a lot of times women don't struggle with their weight. However, as I became an adult, I did. It was something that I continued to fight. So I really do believe I was one of those women that had both. Yeah. Had both. Um, did you ever have iron problems? I did not ever have iron problems, thankfully. That was never an issue for me.

SPEAKER_00 9:01

I saw a lot of patients in blood work where I'm, do you have heavy periods? Yeah, how do you know? Your iron status is low.

SPEAKER_01 9:09

You know what? I I actually should go back up and say I did have iron issues here when I was young because I went to donate blood and I couldn't donate blood because my iron was too low. Now that you say that, I did. I did. Laughing can tell stories. Yes, and very often these things are genetic. So obviously, with my mom, um, she had very similar symptoms with with her menstruation and heavy periods and and and such, and there was no diagnosis for her back then. But but the good news is that it's being recognized for what it is, which is a multi-endocrine problem. So all these women that have unfortunately been dismissed now can get the right treatment. All those women that have been diagnosed that are diagnosed can get the right treatment, and that is going to be addressing things like the liver, mostly, because that's where we process a lot of hormones.

What Endocrine Really Means

SPEAKER_00 10:06

Um I was just gonna ask you, can you explain to us before we dive into the treatment side what endocrine means? The endocrine system.

SPEAKER_01 10:15

The endocrine system is basically our whole hormone system. That's that's basically what it is. And when we talk hormones, I think most people think it's testosterone and estrogen, and that's where it ends. But vitamin D. Right, but vitamin D is even a hormone, our thyroid is a hormone, or cortisol, which people are talking about a little bit more for a stress response. Hormone. We have many hormones in our body, so it doesn't end with just the reproductive hormone. So the endocrine system is basically all of that, and we need to include including our blood sugar, including the blood sugar, and we need to include the detox system as well.

SPEAKER_00 10:53

So the kidneys and the liver, because your estrogen, your progesterone, your testosterone, all of the things when we say hormones that you immediately think of in your mind, they have to go through your liver. And if your liver is too busy executing, getting rid of other toxins, it's not gonna get rid of estrogen, testosterone, progesterone. So when we see things like endometriosis, which is high estrogen levels, heavy, painful periods, well, rather than giving the individual testosterone, because that's the first thought is well, if we give testosterone, we're gonna balance the two of them out. No, we're just gonna flood the system with more hormones. That's all we're doing. Right. Where when I was treating endometriosis, we would focus on the liver and we would detox and we would help the liver get rid of hormones. So as we talk about endocrine system and polyendocrine, we're talking about more than just progesterone, testosterone, and estrogen. Blood sugar is another key piece, and that's number one on the PCOS. So we've got multi-aspects going on here that us functional medicine providers have been tackling for a while now. It's just more people are coming on board. Hallelujah.

GLP-1, Inflammation, And Full-Body Impact

SPEAKER_01 12:09

Yeah, absolutely. I would say um this diagnosis or this name change is also gonna mean that when it comes to the GLPs, because it is a big part of the solution, um, which by the way, there are some studies that are showing that most women that have been diagnosed with what we're now gonna call PMOS, don't produce GLP1 or probably have never produced it at a normal level. So some of them maybe have never produced any at all, um, and but most have produced very low levels, which is why they could no matter what they do, they never could balance their weight on this, you know, they could work out like crazy, but the minute that they didn't do their workout or the minute that they had that ice cream cone scale was going up, and then over time it just continues to noise in the brain, too.

SPEAKER_00 13:00

You're constantly finding the brain noise, yeah.

A Practical Plan For PMOS Support

SPEAKER_01 13:03

Uh it it just and and then full body inflammation, right? So the GLPs are important, not just we we're talking about them so much in terms of weight loss and blood sugar balancing, which is absolutely true, but because we have these receptor sites all over the body on every single organ, and it really does also impact the brain and how that functions with inflammation, how the brain uses insulin. This we're really talking about a full PMOS, we are talking about a full body breakdown. It it there isn't one aspect of your body that, in my opinion, is not going to be showing symptoms. So, with this new name change, we're gonna find that the GLPs are more accessible, probably at some point with insurance coverage. We're not there yet, but this is one step in that direction. So, what do we do? In my opinion, and I'm just one of many voices out there that would agree that we want to go after liver function, like you just mentioned, and there's two ways that we can do that. One is there's a lot of natural remedies that we can do to increase our glutathione production in the body, which is extremely it's the master antioxidant. It is extremely important to good liver function. Um, and we can do things like castor oil packs, eating bitter foods, um, making sure obviously we don't have processed foods in our diets, coffee enemas. I know that that's not one of your favorite things to talk about. It is non-negotiable in my world, but we can do all of those things to help produce glutathione naturally. But if you are struggling to do some of those things, you can go ahead and you can get glutathione as a supplement because it's not a peptide, so it's really going to be more of a an antioxidant supplement, but you can get straight glutathione and support that function. That would be number one. Number two is that we would want to consider MOTS C. Now, MOTS C is often referred to as something that is going to help people with energy levels, but MOTC is going to target the liver and make us a little bit more insulin sensitive. So it's going to improve the insulin sensitivity. It is not going to be the end all BL when it comes to balancing blood sugar, but it supports that. And it also targets visceral fat. Now, a lot of people with PMOS have an enormous amount of visceral fat, which is the dangerous fat that we keep in our belly and around our organs. It's extremely dangerous. So that MOTC is going to, yes, help the mitochondria and the energy production, which are which are suffering, and many women that have this fatigue is a big part of it. But more than that, it's going to support that insulin resistance, that stored uh blood sugar, the stored sugar that's in the liver, and make us help support that blood sugar sensitivity. So glutathione, MOT C, and absolutely the number one thing I would say is getting on a GLP1 and GIP combination. Depending on your goals and depending on your weight loss, would depend on whether you're a microdose candidate or a weight loss candidate. But very often women that are suffering with PMOS are 50 plus pounds overweight on average. So you're going to see them be in a in a situation where they're going to want to probably be on a weight loss program because if if if getting to a healthy weight is ideal, and it is because there's a lot of danger that comes along with carrying extra weight. So you probably would want to do that. But also, I want people to start thinking about giving themselves permission to be on this for the rest of their life. So we talked about a few minutes ago, many of these women have never made it at the level that they need it to be naturally. It's normally made in the small intestines. You produce it every time you eat food, but a lot of these women have never actually made it. And by the way, men can get this too. So it's not even just women, men can get it.

SPEAKER_00 17:13

Mind the listeners, we're talking about they've never made at normal levels GLP one. Right.

Permission For Long-Term GLP Use

SPEAKER_01 17:20

So peptide. So the permission is that you might need to be on this for the rest of your life. Just like we've said this a million times before. A type one diabetic whose pancreas isn't working and is not producing insulin, you would be on insulin for the rest of your life. You have to have it to survive. Which is a peptide. It is a peptide. They've been using it for a hundred years. Yeah, I I read, and you and I have a mutual friend in common. Um, and she put a post out recently about somebody that she knew that was on. I don't know if you saw this or not on Facebook, but she had a mutual somebody she bumped into, they were on GLP one. And her question was, Well, how long do you plan to be on it? And the woman's response is for the rest of my life. And she was astounded. What do you mean you're gonna be on this for the rest of your life? And I thought, oh my gosh, this woman is doing this entire post shaming those that may need it for the rest of her life because she doesn't understand the need for this particular peptide. Yeah, I'll send it to you later.

SPEAKER_00 18:24

Okay, let's talk, let's talk about this because when I when I get questions about GLPs or peptides in general, um, the immediate question is, how long do I need to be on it? Well, how long do you want to have the benefits from it? And and there's more than just the weight loss benefits. So I've helped individuals get on it. I'm like, this is like the best thing you could do for your heart. This is the best thing you could do for your kidneys and your liver and your like your organs in general, because of these additional benefits that we just you know, weight loss is a big marketing aspect. So everybody knows that it does weight loss, but there's so much more to it. And if you need an example, go back to episode number three and listen to Jimmy's story. There's great aspects when it comes to alcohol or recovering from addictions. Like, there's so much more to GLPs and weight loss, and we need to give ourselves permission to be like, you know what? If this helps me feel good, if this helps me live better longer, I'm okay being on it long term. If that means for the rest of my life, so be it. You got on it for brain purposes. How many 80-year-olds, 70, 80 year olds, 90 year olds could have benefited from it if they started 30 years ago? 100%.

SPEAKER_01 19:45

I did it for the brain, but it helped so many other aspects of my life, right? So you just mentioned all that, and I openly talk about this. So if anybody gets squeamish listening, then you might want to plug your ears for 20 seconds while I say this. But prior to me starting, I was having some incontinence issues. And not in the way that after you've had babies, maybe you laugh and you pee a little bit, or you jump on a trampoline and you pee a little bit. I'd had that all resolved with a prolapse with surgeries before, and that was all good. I'm talking about my brain signaling walking to the bathroom, and I would walk there, and the party would get started before I got to the toilet. When I started doing this microdose, that went away. It completely stopped. It was a brain signaling issue between my brain and my bladder. So we have these receptor sites everywhere. So when it comes to a woman who has been diagnosed or suspects they weren't diagnosed, and they were told because they didn't have cis that they did not have PCOS, now PMOS, but you suspect that you did, and you can check off, yes, I have the facial hair, yes, I have the acne, yes, I have difficult or irregular periods, but I don't have cysts. Well, let's go back and get reevaluated and let's talk about this because this might be the thing that you need, and you might need a little bit of it for the rest of your life, and that's completely okay if that's what you did because you're not making it normally.

SPEAKER_00 21:17

Yeah. And when we're saying a little bit for the rest of your life, you're not gonna be on a weight loss dose for the rest of your life. You're not gonna be on maybe like a tiny microdose, maybe once a week, maybe every other week, maybe once a month. Like this isn't a daily thing for the rest of your life, but why not have the benefits from it for the rest of your life? Right. No matter if you have PMOS or if you think you have, or if you're like, you know what, Kylie and Jess, we've been listening to you for 40 episodes now. I'm in. Okay. And that's really what the goal is here is like to teach you guys there's so much more to this than weight loss, and it's so beneficial. So when we're talking PM PMO. Remind me what the M stands for. Um metabolic. Polycurration. Polyendocrine ovarian syndrome. Ovarian syndrome. Okay. Polyendocrine, talking hormones and everything that impacts the hormones, plus metabolic. Hello, blood sugar. And with PCOS, when it came to labs, it was blood sugar and elevated testosterone. That was a typical pattern. And estrogen, or sorry, in endometriosis, it was elevated blood sugar and high estrogen levels. Those were the lab markers that I've I often found with patterns. So the name just makes sense. Blood sugar and hormone problems. Um, the number one peptide you should start off with is the GLP1 GIP combination. Correct. Number two, glutathione, liver.

SPEAKER_01 22:54

Yeah, I would say you're you're pretty much a tie with the glutathione in the MOTC because both of them are gonna Yeah, both I I mean, I'd love I listen, one, two, three for for treating somebody, at least getting them in a better position. But if you have to do one, start with the GLP. And then with the second one, I would say it depends on whether or not you feel your drainage needs support. In other words, let's look at how are you pooping, what does your skin look like, how how is your breathing, your sinuses, all that. Like if drainage is a problem, let's go glutathione. If energy is more of an issue for you, you're really fatigued, and you would say that's at the top of my list. And let's consider MOTC, because both are gonna help the liver. They're just gonna do it in different ways. One, two, three, if you can do all three, but if you can't, start with the GLP GIP and then decide between the MOTC and the glutathione.

SPEAKER_00 23:49

Yes. And and ladies and men, gentlemen, ladies in particular, summer is right around the corner. Go do this for yourself so you have the energy to keep up with your kids and grandkids. Okay? Give yourself permission to go start this and then just watch how much better you feel, not just by the end of the summer, by the end of the year, and then in 12 months, and then in 18 months, and you're gonna look back and be like, I wish I had taken this sooner.

SPEAKER_01 24:26

Right? You know my story. It sat in my refrigerator for a couple weeks, and after I finally said, Oh, I'm gonna do it, I was like, what was I waiting for?

SPEAKER_00 24:37

And I'm still gonna do objections at some point. I'm gonna do it. All right.

SPEAKER_01 24:44

Jess, where can they learn more about you? Absolutely. Come and find me on Instagram where I share tips and all kinds of other fun adventures and education around peptides and all things wellness. That is at JessB.talkshealth. You can also find me on my website. That is b2bwithess.com. And both of those places I can help you get on your peptide journey.

SPEAKER_00 25:10

Yep. Okay, so remember, number one, GLP1 GIP combination, that is trazepatite. When you go to look at ordering these, you're gonna look at the longevity side or the weight loss side. And if your BMI is over 27, that's the weight loss. 27 or 28? 25. Oh, they lowered it. Okay, so if your BMI is over 25, you're gonna be in the weight loss category. If your BMI is under 25, you're gonna look at the microdose longevity side of the trisepatite.

unknown 25:45

Okay.

SPEAKER_00 25:46

Then glutathione or MOT C. Glutathione if you're needing the drainage, and MOT C if you're needing more of the energy. And if you can, you will benefit drastically from all three of them. Just start with GLP G I P if you need the in the to start there, okay, with the income. All right. You know what? And if you're like I would love to get those other two as well. You can make some money doing this too. Get started at drkylyburton.com, whether it's ordering peptides or becoming an affiliate and producing more income for your family so that you can pay for more of your peptides. People are doing it and they're doing it very well, and growing a business with it. So it's just totally up to you and how far you want to take this. Get all the details at drkylieburton.com. This is pep talk, peptides unpacked. See you next time.