#42 Here’s Why KLOW Works Only When Formulated Right

People hear “KLOW stack” and think it’s just a trendy peptide combo. We see something more important: a chemistry and safety problem that decides whether you get real healing benefits or you waste money injecting unstable compounds. 

Dr. Kylie Burton and Jessica Briecke break down:

• what KLOW is, 
• why it’s showing up everywhere, 
• and why doing it “DIY style” can backfire when you don’t understand formulation, pH, and receptor competition.

There are four peptides inside the KLOW compound. Let us teach you about each one and why this powerful combination is powerful - unless you're trying to play biochemist. Along the way, we share practical context on routes of use, real injury examples, and why people often feel drawn to stacking in the first place.

Beware: these peptides don’t automatically “belong together” unless the biochemistry is handled correctly. What exactly does this look like? It's all about the pH. You CANNOT do this in the kitchen safely and effectively. If you are, you're wasting your money. 

If you care about faster recovery, lower inflammation, better mobility, or healthier skin from peptides, listen closely, share this with a friend who’s tempted by the gray market, and subscribe for more clear, science-forward breakdowns.

Want to connect more with the hosts? We'd love it! Connect with Jess at B2BwithJess.com/peptides or on Instagram @jessb.talkshealth. Grab your Blood Work & Peptides Mini Guide for free at drkylieburton.com. 

Ready to explore peptide therapy for yourself? Visit the company we recommend for pharmaceutical peptides and receive all the one-on-one support that comes included at drkylieburton.com

Want to offer peptide therapy in your business? Whether you're adding it to your existing practice or building something new, learn how to get started—and how we'll mentor you along the way—at drkylieburton.com

Legal Disclaimer: This podcast is for educational and informational purposes only and is not intended as medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before starting any new health protocol. Dr. Kylie Burton and Jessica Briecke are affiliates and may receive compensation for referrals. Individual results may vary.

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Transcript

Why KLOW Matters

SPEAKER_00 0:02

Peptides are powerful and often misunderstood.

SPEAKER_01 0:06

And we're here to change that one conversation at a time. I'm Dr. Kylie Burton, and I'm Jessica Brickie.

SPEAKER_00 0:14

This is Pep Talk. Peptides Unpacked. If you've ever heard of the stack known as Clow, K-L-O-W, and you might have thought, you know, what is this all about? Could I benefit from it? Well, this is the episode for you. We're going to talk about Clow. Jess, lead the way.

SPEAKER_01 0:36

Yeah. So four peptides compounded in one. And a lot of people have been out there kind of doing it on their own. So we're going to talk about what these four peptides are and why that isn't something that you should be doing. And then how can you do it in a safe way? So let's first like break down the four peptides. So in this, you have BPC157, TB500, GHKCU, and then KPV.

GHK-Cu Beyond Beauty Benefits

SPEAKER_01 1:07

So we're going to start with the copper peptide, the GHKCU. And a lot of people love this. They'll do it by themselves because they want to have the pretty skin and the hair and the nails and all that, but it is so much more than that. So GHKCU is a copper-bound tripeptide. And that copper is the important part here. It's what it gets gives it the color and the biological activity. And if you take out the copper part of it, then you really got a whole lot of nothing. But this is going to target your skin and your tissue repair. It's going to stimulate collagen, which is why everybody likes it so much for their skin. But it's also an anti-inflammatory signaling peptide, tissue remodeling. It's naturally occurring in human plasma. And it does decline like many of these peptides too with age, but also with poor diet and stress and so on and so forth. So that's the first one. And people love that. They think of it as the beauty peptide, but it's deeper. The

BPC-157 For Gut And Joints

SPEAKER_01 2:11

next we have body protection compound. That's our BPC157. It's your favorite. You love this one, right? You're it's the one that it's where you started, I think. If I'm not oh, maybe you started with the methylene blue, but that that was your I did them both.

SPEAKER_00 2:24

Yeah.

SPEAKER_01 2:24

You did them both. Okay. Um, this one has been around for a minute. So everybody's talking about it like many of these peptides. This has been around and studied and used for about 30 years. This is not brand new like everybody thinks it is. And it was discussed, it was actually discovered in the early 1990s, derived from a protein found in the human gastric juice, which means our small intestines are producing this. Um, so it's not unfamiliar to the body. We know what to do with it if we're making it properly. It's made in the small intestines when we eat. It's going to target our tendons and ligaments and gut healing, the soft tissue in our body. Um, joint repair, that's a big one. I know that you were targeting it for your knee, right? Yeah. How is your knee doing, by the way? I haven't asked you.

SPEAKER_00 3:12

Has it helped you? I made it so on the Ogdamarathon, which was this past weekend, middle of May, a friend that was running the half, and I was like, okay, well, I'll meet you like the last three and ran the last three with her. I could the funny thing is, is when I I've had problems with my right knee. It was my left knee that had the issues. So that tells me it's like, okay, it's not something, it's not damage per se in the knee. This could be structural, but it's also like right where if I could pinpoint it, it would be right where the fibula and the hamstring come together. Okay. So that back hole, and I know like my my calves are tight, my thigh, my hamstrings are tight on both legs. And so I'm gonna do some like structural work, get some adjustments, get some massages, and add in the BPC injections. And I think once we add in those injections, it things will really start to ramp up. I have till October 3rd, because then I'm running a half marathon.

SPEAKER_01 4:18

That's right. Well, the thing is too, you did the capsule version, which is really gonna be better for the gut repair. And I think the injections you're gonna find is gonna be a better um implementation for I'm hoping that we can stick injections in the thighs. Can you do that? You yeah, oh, of course, you can. And a lot of people with the BPC will do it at the site of where the injury is, although there's been studies that show it really doesn't matter. You can do your belly injections, your thigh injections, your upper arm, whatever. The body's gonna take the TB500. Yeah, well, but the TB500 component of of all that is kind of like the director, the traffic director. So it's gonna bring it where it needs to go. So, yes, you can do it at the site, and some people feel that that's better, but there's a lot of studies that have shown that it's not necessary. But yes, either way, you can do it in the thigh, you'll be just fine with that. Um, so I'll stay tuned. We'll learn when I start these injections. That's part two of the Clow Comp uh stack uh compound.

TB-500 As The Repair Director

SPEAKER_01 5:16

We have the TB500 that I was just mentioning, that is the thymocin beta 4 fragment. Um, it's a protein that's naturally present virtually everywhere in every cell in your body, and it works systemically, not just where you inject it. So, like I was just saying, it's kind of like the traffic director. This it's going to target um muscle repair, inflammation reduction, tissue regeneration, flexibility, and range of motion, which is awesome, especially when we're in this age of so many people having like shoulder injury, knee. That is a big one for that.

SPEAKER_00 5:52

Um conversation we had with Heidi on the previous episode, um, when she was like, I tore my hamstring and I'm and it rolled down her leg. I watched my brother do the same thing, his senior year of high school. First track meet of the season. Oh, that's right. You remember you talking about that. He's getting scouted by different colleges and he loses hamstring right off the bat. And he had struggles with it for the next five years, still has struggles with it now, 15 years later. And it's like, I just I just wonder what would have been different with recovery if we had access to the peptides.

SPEAKER_01 6:28

I would have been completely different for sure.

SPEAKER_00 6:31

Yeah.

SPEAKER_01 6:32

So TB500, we often see stacked with the BPC 157 by itself. It's referred to as the Wolverine stack. And there is some overlap, but they have very distinct repair jobs. So, in the so far in the CLO stack, we've now got the GHKCU, we've got the BPC157 and the TB500.

KPV For Immune Calm

SPEAKER_01 6:54

And then the final one that we have in the CLO is the KPV, which is an immune modulator. It's also a tripeptide, it's a fragment of um another stimulating hormone, which originates in the pituitary-related pathways. So we like to think about all the things that the pituitary responsible, it's kind of at the top of our chain, which we talk about in other episodes. Um, this is a very powerful anti-inflammatory and immune-modulating peptide, but we are going to think gut, we're going to think skin, systemic response with this one. Um, it's going to greatly influence the HPT access, which is the hypothalamus pituitary thyroid. Um key point here is that it is a it is really great at lowering inflammation, like some of the other ones, but think of KPB as almost like your peacekeeper. Like it's just gonna kind of keep everything in check, keep everything calm. Um, and it does connect to the thyroid, but indirectly, right? Because we're talking about the pituitary knot there. So those are the four peptides that we have, which a lot of people are you can inject them separately and be just fine.

The Risk Of DIY Mixing

SPEAKER_01 8:14

But what's happening out there is that a lot of people are trying to have less pokes, and so they're loading the needle on their own because we have so many people playing pharmacy in their kitchen, and they're putting these peptides together that do not belong together. Now, you and I represent a telemedicine company where they are doing wonderful things, extremely transparent in the way that they're doing those things, and they put out some information about the pH science behind this. So I'm gonna give you some numbers which to the average listener, right? Yeah, let me just add this one thing.

SPEAKER_00 8:52

Yep. The owner of the telemedicine company that we are working with and have partnered with, she is a biochemist. She has a biochemist background. So when she's explaining that we now have this stack available, when for so long we thought, no, that doesn't work because of the copper, it makes everything negate, it negates everything else in there because of the right. Yeah. She explained it to us from a chemistry perspective. So just share away.

SPEAKER_01 9:21

Yeah.

The pH Science Behind KLOW

SPEAKER_01 9:22

So one of the biggest things that uh copper can compete for the same receptor sites as some of the other peptides will do. Uh, if we put this in a stabilized formulation, we're not going to be competing in the same way. Everybody's going to have the opportunity now go to their designated receptor sites and do their job. So what's interesting is it's a very tiny point. And I'm just, these numbers don't really mean anything as I say them, but it'll come together in just a second. So GHKCU has a stable pH range of 4.5 to 7.4. The optimal 5.5 to 6.5. Okay, great. BPC 157 is 5.0 to 7.5. The optimal range, 6.5 to 7.0, right? So GHK was 55 to 65. Now BPC's optimal range is 65 to 7. TB500, their stable range is 5.5 to 7.5. Their optimal range is 6.5 to 7.0. And then you have KPV, whose up their stable range 5.5.0 to 7.5. And the optimal range is 6.0 to 7.0. What does that all mean? In each and every one of those, there's only number. Yeah, 6.5 is the only one where they all cross over. That's the only number. So we this our telemedicine company and the brilliant people behind it recognized that and put formulated and stabilized these peptides so that they could all be at that pH and be in the same compound without destabilizing each other, competing with each other. Then they took it another step further and then they tested it in conditions with heat, refrigeration, and room temperature. And it all remained at the same pH and all remained stable. Phenomenal. So the proof of these particular peptides in our body is very clear. We know what each one of these things do. There's a ton of science behind each one. It's why people want to use them all together because they all have such incredible benefits on their own. But when you put them together in one powerhouse compound, that is going to change the trajectory of healing on multiple levels, even where you don't even realize that you need healing, that's going to happen. So people are out there, they're in the gray market using God knows what, at whatever pH, loading them up in a needle and inject it blows my mind, injecting them into their body and then creating problems because they're not doing it safely or understand the science behind it.

SPEAKER_00 12:08

Safely, and I can almost guarantee that pH is wrong. Right. Which means it's not even working. You're not even getting the benefits because you're killing the peptides themselves with the liquid. It's it's wild.

Real Recovery Story And Cautions

SPEAKER_01 12:20

The there is um a person that works at the at corporate for the telemedicine company, and she told a story about last fall, the pharmacist behind this put this together for her when she was having her knee replacement done. And she went in after her knee replacement for her two-week post-op visit. And first it was the nurses that did the intake with the same response. And then when the surgeon came in and looked at it, every one of them thought she was coming in for her two-month follow-up, not her two-week follow-up, because her healing had been that remarkable. So that was before you know we had had it available to us. They did it kind of as a special, special thing for her, put it together, and that was her experience. I mean, that that's a tough surgery. And to say that, you know, basically it it put her eight weeks or six weeks ahead of the healing schedule because she was using this stack. I think C-sections a hundred percent.

SPEAKER_00 13:22

Have that to your put your recovery.

SPEAKER_01 13:26

It depends, though. I would say it depends on if you're breastfeeding, right? Because there is, if you're breastfeeding, then we're we're do I think because these things are naturally made in the body, this is not medical advice. Let me just say this. This is not medical advice. Let me just say this is mob advice coming from us, right? This is just my thoughts. These are things that we are naturally producing, and so yes, they're synthetic because they're lab made, but they're made to match what we naturally make in the body. The body knows what to do. That do I think that there's really going to be a danger point with maybe using it if you're breastfeeding? I don't really, but we don't, but I don't know. So I would never advise anybody to do that. And that's part of the screening process. If you are doing that, if you're nursing, that would be flagged and say, nope, you're not gonna you're not gonna do that. We're not gonna take the chance. But we make these things naturally, so it would make sense.

SPEAKER_00 14:17

And definitely can't breastfeed. I was just gonna say, so if you're not breastfeeding, produce. I didn't even try with my third. Yeah. So it does me. I can heal faster from other things if I'm yeah, unwilling to not go the breastfeeding route. And it's just like my body just wouldn't produce, and I accepted it, and I was like, that's okay. I'm gonna die for like a day until my boobs overcame the engorgement, which I don't even know what from because I didn't even produce anything then either.

SPEAKER_01 14:47

But, anyways, sorry for we just see people um that are using the stack that are feeling their best and they're looking their best. It's like they're turning back the clock of time, the the the the clock of time, the clock of the feeling good and looking good, internal and extra external.

SPEAKER_00 15:04

Absolutely. We want you to be healthy on the inside just as much as healthy on the outside, and that's the beauty of these peptides, with the clo being the latest. And it's like if you want to have the benefits of four peptides put into one stack and only pay for one and get one injection, this is a simple solution.

SPEAKER_01 15:24

I will say it's a pricey peptide. But if you were there's four of them, number one, but number two, if you were doing them individually, it would cost you a lot more. It's the same dose as it is if you're doing them individually. It would cost you a lot more to do them individually than it does to do that in this compound. But the benefits from this this compound are it's phenomenal. It's a home run.

SPEAKER_00 15:47

Hello, ladies and gentlemen, K-L-O-W. Jess,

Cost Value And How To Start

SPEAKER_00 15:52

where can they find you? Absolutely.

SPEAKER_01 15:54

As always, you can find me on Instagram, jessb.talkshealth, and you can grab me at my website, b2bwithess.com.

SPEAKER_00 16:03

Please, if you get anything else from this episode, stop playing pharmacist in your kitchen. These need to be done under pharmaceutical biochemistry labs, like with elite experts doing them. And make sure you have medical attention, medical providers working with you. That's why we've combined our partnership with our telemedicine company. Neither Jess or I have pharmaceutical rights, nor do we want them. So we're gonna help you find these peptides safely with guidance and with the right oversight. So get started at drylaburton.com. This is peptick. Peptides unpacked. See you next time.