Salmon Sperm Hype vs. Evidence

The salmon sperm injection trend is everywhere — but the evidence isn't keeping up with the hype.

In this episode of Aesthetics Unscripted, Kim and special guest Co-Host Will Love take a thorough, evidence-based look at PDRN — the ingredient behind the viral salmon sperm skincare trend — and ask the question most providers aren't asking: does it actually work?

They break down a retracted split-face trial that showed no meaningful difference between PDRN and hyaluronic acid filler, why PDRN metabolizes too quickly to deliver lasting results, and the glaring research gap — almost no controlled studies comparing PDRN directly against PRP. 

Add to that a supply chain riddled with unregistered products, synthetic substitutions, and sourcing fraud — and the picture becomes clear. The results people are seeing online are most often driven by the other treatments being used alongside PDRN, not by PDRN itself.

Honest, research-backed, and exactly what you need before making any decisions about salmon sperm injections.

Transcript

SPEAKER_01 0:02

Well, they clearly didn't for a reason.

SPEAKER_00 0:04

Right. So again, as a potential patient, you know, now I'm to at this point I've progressed to extreme doubt. Yeah. So I'm sitting here doing just, you know, an hour's or a half an hour of the street.

SPEAKER_01 0:15

Research if you're debating getting a series of treatments and you find all this out, no point.

SPEAKER_00 0:20

Exactly. Exactly. So what the trial actually showed before it was retracted, um, not just to bash reguron, but they did prove that it was up against a HA filler and against that hyalinic acid filler in a split face design. So 72 patients had one side reguron and one side HA filler. Um, animal data looked favorable. See, the first was actually on animals.

SPEAKER_01 0:47

But in the actual human portion, that that just irritates me because it's smoking mirrors again. Is an animal getting filler?

SPEAKER_00 0:55

Right.

SPEAKER_01 0:56

Yes, is an animal getting cosmetic treatments? No, of course not. Outside the fact that it's tested on animals, and I feel bad for the animal. But really, an animal isn't gonna need filler. So compare if an animal got filler on one side and salmon sperm are on the other side and the spem salmon sperm looked better. Okay, that's not us. That's not a human.

SPEAKER_00 1:16

Right, exactly. And unfortunately, I couldn't find um in that original paper because it was retracted, I couldn't find any reference to was it a pig, which we know is, you know, chemically um or close to our certain valves and things that we could use, and we're finding now there's trials actually, side note, going on, which I find wildly exciting around the world for actual pig corneal replacement um in humans. Oh wow. There it looks very promising. So, you know, we have to really thank our pigs when we get a chance to. Whether you eat them or not is up to each individual, but be thankful either way, because I think we're gonna take another step forward in being able to help humans through them. But uh so to go back to laughing about it, right? But it's we're laughing, but it's serious. That the first, the beginning of the trial was actually split face on animals. And then in the human, the primary and secondary objective efficacy measures showed no statistical significance between re-juron and HA filler. Zero. Zero.

SPEAKER_01 2:25

The only difference And you're not even a filler person, but I'm sure at this point, even you would say get the filler.

SPEAKER_00 2:31

Right, because HA, as you know, it's it's um, it's cre that that filler is created a little bit differently than the older fillers. It's you know, it's not meant to be permanent, it's like a semi-permanent thing, it's meant to be more gentle in the face, etc. I'm still not a filler person, except for lips, but um, but it's very interesting to me that even Rajuron in a split face human trial couldn't show an improved difference. But the only difference between PDRN from Rajuron or any other company and an HA filler is that your PDRN is going to wear off very well.

SPEAKER_01 3:05

Way quicker.

SPEAKER_00 3:05

Yeah, very rapidly. It's the reason, like you said before, why are we doing this like once a month for X amount of months? Because we're trying to build up a cumulative benefit, but that's going to race its way right out of your skin through the daily aging process. So they're not having issues with like a lot of lawsuits for side effects because it's racing through your body.

SPEAKER_01 3:24

Yeah, it's being metabolized right away. You're just you're just wasting your money. There's plenty of other things you could waste it on cosmetically.

SPEAKER_00 3:33

You could do some cell, not waste it in the city. Exactly. Yeah. Hey, now let's talk about seriously. You know, I'd love to talk about that all day long, but um, let me let me focus on PDRN. Let's talk about now the uh a glaring design flaw with any of PDRN studies from any company, which is PRP versus PDRN. So um just a quick cap here for anyone that doesn't know what PRP is yet. It's platelet-rich plasma. We do a blood draw and centrifuge in specific tubes for a specific amount of time at a specific speed to remove PRP, which is that plasma from your blood, and then reinject it for uh a new growth spurt or stimulation in the purpose of longevity and anti-aging. So it does need to be done in a series of treatments in the beginning, usually once a month, and then a single maintenance treatment periodically. Yeah. Because again, we age daily, but it's chemical-free, it's from your body back to your body.

SPEAKER_01 4:35

So a lot of people get it in certain areas. I want to do a series actually underneath my eye area.

SPEAKER_00 4:41

That's great in that area. So we'll have to come back and do another podcast about that.

SPEAKER_01 4:44

Yeah, for sure.

SPEAKER_00 4:45

Um, so what I found very interesting, Will, and I can't wait to hear your take on that, is that no company has done a split or whole phase side-by-side comparison trial with to me what is a no-brainer of PRP versus PDRN. No one's done it.

SPEAKER_01 5:02

Well, they didn't because the thing with tabolize is gonna show no results like it did with the filler comparison.

SPEAKER_00 5:06

Right, right. So maybe that retracted um potential white paper resource from a germ being retracted scared all the time.

SPEAKER_01 5:16

Hyaluronic acid filler typically will last longer than PRP, right?

SPEAKER_00 5:20

Yes, absolutely.

SPEAKER_01 5:21

So if PDRN is gonna fail in comparison to HA filler, it's gonna fail in comparison to PRP. You know what I mean?

SPEAKER_00 5:31

Exactly. And forgive me if I'm wrong, and I invite companies to please submit their white paper studies. If anyone has released worldwide anywhere their own PRP or they've even submitted and are waiting for the results to see if they're going to get published for their side-by-side comparison with PRP, I'd love to read it. I'm here for it. And I'm I'm totally respecting of any company that has done that recently. But in the flagship trial, like I said, there was no PRP arm. So classically, you would have a control arm. The control is the PDRN. Then you'd have a control arm, which would be the HA. But there's nothing stopping that company from going to the third arm, which would be PRP. And they could have done it all at once.

SPEAKER_01 6:14

They could have, yeah.

SPEAKER_00 6:15

You know, so in any any major country that's focused on beauty to the extent of South Korea, like I said, not just 20 or 50 people. They could have had hundreds, they could have had thousands of people line up to do this study and have it completed and submitted for publication in 12 months or less. So so why hasn't that been done? Um, but the question's never been answered in a controlled trial. There's no placebo, there's there's just nothing. And we do have uh a building body of evidence for PRP efficacy.

SPEAKER_02 6:43

Yes.

SPEAKER_00 6:43

Does it wear off faster than a chemical filler? Yes, because we've talked about it, you know, almost ad nauseum at this point, about how it will cycle. It's natural, we age daily, it cycles through your body, you have to keep up with it. You know, it's just like going to the gym.

SPEAKER_01 6:56

But it's still gonna last a hell of a lot longer than the salmon sperm.

SPEAKER_00 7:00

Right, right. When we're looking at the whys and the wherefores, it really is starting to build a strong case against why suddenly PDRN doesn't make sense. Like it sounds like a resounding no. And we can take that even further for hair injections with limited PRP and PDRN comparison data. Uh, the only context, however, where PDRN and PRP have been formally studied together is hair loss. And the result, um, unfortunately, again, I hate to say it, but PDRN was the loser. It was not the standalone claim for PDRN is from the individual companies, again, with no resources, no clinical trials to actually prove because PRP injectable for hair no third-party bipartisan study. Right, exactly. So for hair growth simulation, PRP when there was a side-by-side, won every time. So, again, I invite any companies out there that have some positive results that are swinging clearly into PR PDRN versus PRP that PDRN is better, we'd love to see it. Because unfortunately, to this point, there is nothing. Um, and SCAR and burn case studies using specifically Rejuron and PRP plus neurotoxin, so plus Botox in particular, in combination had good results for scar and burn advanced healing, but cannot be contributed to any single ingredient. So those studies.

SPEAKER_01 8:33

I think that was primarily the PRP and neurotoxin element.

SPEAKER_00 8:37

This is interesting because those studies itself specified that they could not pinpoint within the study was it the neurotoxin, uh, you know, was it the botulism? Was it the PRP or was it the PDRN? They themselves couldn't differentiate.

SPEAKER_01 8:53

Right, but those more than it was the salmon sperm.

SPEAKER_00 8:56

Right, but their own their own scientists couldn't even tell you that. So, you know, if they can't explain it to us, what are we supposed to feel about it?

SPEAKER_02 9:03

Yeah.

SPEAKER_00 9:03

So I found that whole thing was very confusing. Um, and then we're also coming up to the broader evidence base. Um it's it's thin across the board, and when you're talking about red flags, you know, you of yourself have waved the red flag here at this podcast a few times on this subject. A 2025 systemic review and journal of cosmetic dermatology. Only nine qualifying studies found across all databases, which is a total of just 219 patients across the entire evidence base for PN in aesthetic medicine. Um, in this small trial by pharmaceutical standards is not remotely sufficient for regulatory approval or definitive clinical conclusions.

SPEAKER_01 9:45

There we go.

SPEAKER_00 9:47

Right. So for any in-clinic study, which is usually called the study, not a trial, that's when you'll see on the back, and this is legal, and there's no hijinks usually about it. Yeah. You could have a study with five patients. You could have a study with eight patients, you could have those in-clinic trials with the smallest amount of patients as you want. I've literally seen beauty products that said on the back when tested on three patients, there was like 97% positive results. It's in fine print. So that's not illegal to say because they literally only tested on three patients. If you personally find that efficacious enough, then buy the product. You know, if you question that, then you're gonna wait and see if the company has anything to do with a bigger trial. So even a trial of like 100 patients sounds like a big trial. But for example, in the US for FDA standards, you're talking 250 patients minimum, but preferably 500 to 1,000, and preferably tracked over 12 months. So two to three year mark is more the standard of body of evidence that the FDA is looking for. So it's a huge deal when you're doing a study to prove efficacy versus FDA clearance or FDA approved. So please don't mix up both. It doesn't mean a product's bad. Like, for example, you know, when we go through the to go back to Somacell for hair growth, we go through that in-clinic trial in the beginning. I'm not gonna do 2,000 patients and track them for three years. Yeah. So I'm looking to prove efficacy for advanced um stimulation for hair growth in a short amount of time because that's the key for me. I want to see if we can help your hair grow faster and you don't have to wait six months for that to happen.

SPEAKER_02 11:29

Yeah.

SPEAKER_00 11:30

So that's why I'm being very clear about the standard of evidence that we're gathering. I'm not trying to tell you and trying to lie to you that it's gonna be an FDA cleared study, like an official one, because it's not, not in the beginning. Maybe we'll advance into that later, but we're not gonna take 2,000 patients and track you for three years. So um, you know, so people need to understand that there are minimums um and that needs to be put out there, otherwise it's a big red flag. You know, we have to understand marketing versus proven efficacy, even from smaller trials, versus pure red flag, smoke and mirrors. And then that brings us into the subject of the mechanism isn't fully understood. You and I are going through this whole thing, and you know, I've I've researched this to death, and I still don't fully understand the mechanism.

SPEAKER_02 12:24

Yeah.

SPEAKER_00 12:24

Right? So, why is PDRN supposed to work in the human body? Technically, there's two pathways, adenosine A2A, receptor stimulation, and the DNA salvage pathway. And the critical problem is no research has confirmed which pathway is actually operative in human skin. So there's that problem. Or whether either is meaningfully activated by injected salmon DNA fragments in cosmetic content. The biological plausibility is another issue, but plausible is not the same for each person. So this is another problem because when we have the salmon sperm, that DNA, it's actually a fragment of the DNA. So we think, in terms, as patients, we think, oh, if you tell me something, I'm thinking it's a whole thing. Yeah. Like it's your bottle of water, but it's not because maybe it's a bottle that only has three drops of water in it. So this is the difference. And your bottle of water, you know, might have a half, be half full with water, and my bottle of water might have the three drops. So when you go from pathway to pathway, each person's body responds differently. So this is a whole nother problem that we have when it comes to deciding if this is efficacious or not. Paying hundreds of dollars for a treatment whose mode of activation remains a theoretical framework to me just sounds like silly. If you want to throw your away. Well, that's what I mean.

SPEAKER_01 13:46

You're really throwing your money away on something that there's no real genuine concrete study that it's doing anything anti-aging related.

SPEAKER_00 13:55

Absolutely. Exactly. And I really wanted to be able to find evidence to say, hey, you know what? I love eating salmon. I love watching documentaries about this incredible struggle that salmon go through for, you know, to get back up those streams to go spawn where they were originally born and then die there. I'm always fascinated by everything having to do with salmon. So I really wanted to get behind this. But as you can see, the more we unpack, the more I'm just like, dude, what is happening here? Also, let's talk about the 61% wrinkle reduction headline.

SPEAKER_01 14:29

How long does that last now? Let's see. Does that what? We're talking not even a month?

SPEAKER_00 14:34

Um, marketing ploy, 60.

SPEAKER_01 14:37

That's what I mean. You're gonna waste your money. At least try one of the neurotoxins.

SPEAKER_00 14:39

Right, right, right. So get a lot of. And that's where the neurotoxic is.

SPEAKER_01 14:46

No, this shit would not work for me at all.

SPEAKER_00 14:48

Uh it'll work for like a day, but you could also do a hydrofacial for a day. Yeah. You know, for and get a great glow. Or you could do dermaplaning and get glass skin for a week. So these are proven things at least. Um, so the numbers are 61.4% reduction in periorbital wrinkles at 12 weeks, and 213 Asian subjects is cited everywhere as proof. From every PDRN company, they grabbed onto this one thing.

SPEAKER_01 15:14

But well, clearly they had nothing else to grab onto.

SPEAKER_00 15:20

But what isn't mentioned is the manufacturer-affiliated study, single homogenous population. So it's only Asians, and uh Asians are known, and this is a biological fact, Asians are known to have thinner epidermis and at different and different aging patterns. So let me repeat that because I'm kind of like blah. So different aging patterns and thinner epidermis. So it's easier to take someone with thin skin and show this miraculous new glow as opposed to someone like yourself that has a thicker epidermis.

SPEAKER_01 15:56

Um, double the units of neurotoxin. Right, yeah. Right.

SPEAKER_00 15:59

So you can, I mean, I don't know, maybe to the average person watching this podcast, they can't tell the difference. But when I look at your face versus mine, I can tell that your skin is thicker automatically. And I would have noticed that before I was in aesthetics as an expert provider. So it's just because your your actual genetic makeup has stronger skin behind it than mine does. Um, so it's a beautiful thing. And we want to keep it looking that way. But understand that when it comes to this miraculous 61.4% reduction in periorboro wrinkles, if it's only done on one type of person and these people also are not tracked for any length of time whatsoever, um, what are we proving?

SPEAKER_02 16:43

Yeah.

SPEAKER_00 16:43

You know what I mean? Like, what are we proving? We proved that for Asians, this could be a really great idea for the short haul.

SPEAKER_01 16:50

But I feel like they were also specifically chosen for the study because, like you mentioned, their skin is thinner, so it would show a quicker reaction.

SPEAKER_00 16:59

Right. And some of the biggest PDRN companies are coming out of Asia, so I'm not throwing stones. I'm half Korean. Hey, I'm all for it, you know. But I'm just saying we have to look at the reasons behind you're seeing these miraculous headlines, right? I mean, come on, it's all it's called marketing and advertising for a reason. Uh the regulatory and supply chain red flags. So we're going back to more red flags. We already know I can go over them very quickly. They're not FDA approved for U.S. cosmetic education. A lot of things are not, cosmetics are not regulated yet in this country by the FDA to begin with, but this is an injectable product we're talking about, not just a topical product. So you would think that the injectable part of the product would be coming under regulate regulatory scriptures. Exactly.

SPEAKER_02 17:44

Yeah.

SPEAKER_00 17:45

And, you know, we're we're hearing crickets from that side right now. Uh again, someone please, you know, reach out to Aesthetics Unscripted and correct me if I'm wrong, because I'd like to update that if that if the FDA is now finally taking a look at PDRN, but we don't have anything as of this moment. So uh the Philippines FDA issued a public health warning against unregistered PDRN and Regione products circulating in the market.

SPEAKER_01 18:12

Oof.

SPEAKER_00 18:13

Yes.

SPEAKER_01 18:13

That's what I mean. There's a plethora of them.

SPEAKER_00 18:16

Exactly. And the problem, as we spoke over the yeah, reading about it constantly lately. Right. And uh it's like cod, cod sperm, cod sperm, cod sperm. But then also, you know, like what I had touched on, it's not just the source, but it's also the processing. So at least Rajuron has a very sterilized processing of their salmon guaranteed PDRN. Um, so whether it works or not, you also have to worry about the allergic reactions and possible negative side effects if this stuff is not processed properly. So bad enough, it's not salmon sperm, it's cod sperm, but it's it's like this questionable type of processing. Yeah. So what are you letting people inject in your face? It's very scary.

SPEAKER_01 18:56

It's a big gamble for something that's barely gonna work.

SPEAKER_00 18:58

Yes, exactly. And this um the product uh heterogenicity across the PDRN category makes cross-study comparisons nearly meaningless. So there's just not enough of a broad range reach when it comes to the clarity of the companies supplying it. They should just be, it should be printed right on their box. You shouldn't have to go looking for the information. Guaranteed PDRN, salmon fragmented DNA, uh, sterile processing, etc. You know, like when we get needles for injections, the proper needle will say individually sterilized packaging, guaranteed sterile needle. Like these are all things that automatically come on the package. So if you're gonna let someone inject something in your face, or you're gonna buy something to inject in someone's face or use topically after a micro wound, why wouldn't you want that very clearly stated?

SPEAKER_02 19:56

Yeah.

SPEAKER_00 19:56

You know, that alarms me. And the bottom line on Reguron, it's not great, Bob. So hate to say that, but Reguron is um genuinely superior to VAMP when it comes to being injectable because people are injecting it, as we said, and they're not supposed to be injecting VAMP or VAMP advanced. So that right away is a problem. If you're a VAMP provider or Vamp advanced, you're not to be injecting this product. So all the problems that we said before will stand up. There's no clinical trial anywhere. It could have easily been done at this point for by any company.

SPEAKER_02 20:34

Yeah.

SPEAKER_00 20:34

Uh rampant that it's not the right product, uh, rampant that it's not it's questionable about a lot of companies on how they even manufacture the product and source the product.

SPEAKER_01 20:45

Throw in the fact that there's a lot of fraud with this and a lot of fake salmon on the market that is actually cod.

SPEAKER_00 20:55

Oh, and that brings up another thing. And you and I talked about this privately. There's also the synthetic versions that are not disclosed as synthetic versions. They're not even real animal fragmented DNA. It's all just chemical product.

SPEAKER_01 21:10

There's so much fraud for a product that's clearly showing to be very ineffective with minimal results.

SPEAKER_00 21:18

Right.

SPEAKER_01 21:19

With so much out there today, I really don't know why one would spend their money on this.

SPEAKER_00 21:25

Exactly. But you know what? I think a lot of the social media um smoke and mirrors with a lot of posts creates another issue.

SPEAKER_01 21:32

But then all the med spas uh buy in on it so they have to promote it, and they'll say anything to like get a sale on it.

SPEAKER_00 21:39

Exactly. But you know what I think one of the problems with a lot of the posts are is that um you'll watch the reel and they'll be like, you'll see the bumps and you see the clickbait, and you're like, ooh, the here I am with the PDRN. Some of them are honest and say it burns like hell. This is really painful. You know, I'm not happy, this better be worth it, and then clicks over to the next one crazy, crazy glow. But if you Don't actually read that caption, which I found is becoming a huge widespread problem all over the world. People are just visually engaging in social and they're no longer even reading the captions on those same posts. The captions are saying, for example, I flew to Korea, and in one day, I got a laser resurfacing and microneedling and an oxygen treatment. So they combined it as well. And I got PDRN and I got neurotoxin. Right. And they had like this whole afternoon of this massive overhaul just on their face alone, much less what they're doing on their body. Yeah. And they are legitimately listing it in their post, but nobody's paying attention because the only thing in the post is PDRN, lumpy, bumpy face, and then glowy skin.

SPEAKER_01 22:39

Yeah, and people assume it's just from that. Whereas they did five other things, and the those other treatments that they did are more effective. So the glow is likely not from the salmon sperm alone.

SPEAKER_00 22:52

It's exactly.

SPEAKER_01 23:33

Yeah, exactly. And I did that recently. I did the uh H bot, I did Soma Cell, Microneedling, PRP, and Daxavide.

SPEAKER_00 23:42

Yes, all in one day. And the H bot is mild hyperbaric oxygen therapy chamber and it's on Will Social. Can you remind us what your social is again? Because I know you put you put you were storing in that.

SPEAKER_01 23:51

Oh, yeah, at Will Love Inc. If you go Will LoveInc, you'll see I did a full day of regenerative beauty at IT intelligent treatment. Started with the H bot, then did Soma Cell, then did Microneedling, PRP, and Daxify.

SPEAKER_00 24:05

Yeah, it was a lot of fun. And you're you were like, ah I want to do it again. So it's great. It was an honor and a pleasure to have you there. We just he had a great time, we had a great time, and you can tell shows on his face. And for the longevity also, because the things we're doing is to build up a to bolster your body against the daily aging process. So we're doing cumulative things to stave off what is happening to our faces and our bodies on a daily basis.

SPEAKER_02 24:34

Yeah.

SPEAKER_00 24:34

So to wrap up with uh what's actually producing the results from the real story, you you hit on that yourself just now.

SPEAKER_01 24:41

Well, it's everything else that they're doing.

SPEAKER_00 24:43

Everything else combined. Yes, it's like the wounding, right? The microneedling, the chemical peel, the laser. You know, that was targeted for specific and then adding hyalinic acid, adding amino acids, adding your antioxidants, adding your peptides. All of these things are proven drivers for, you know, whether it's slightly or at a longer rate of staving off the that, you know, marching across your face of time. So it's giving you visual benefits while it's giving you the chemical molecular response, which are beneficial.

SPEAKER_02 25:15

Yeah.

SPEAKER_00 25:16

But these are things at least that we can definitely understand and trust because there's so much clinical evidence that's come in worldwide for these things. And then you're throwing the PDRN on top and then you go.

SPEAKER_01 25:27

Which is really nothing. It's a miracle. But then it's getting all the credit instead of everything else. Exactly, exactly. That you did the same day.

SPEAKER_00 25:33

Yeah, that's like um what we all, you know, it's happened to everybody at one point or another. Maybe it was in high school, maybe it was at your job recently, but you're on a team and nobody's pulling their weight except you. Yeah. And you brought together this amazing result or this awesome presentation and nailed it. And then, like, five other people on your team who did no work get all, or one other person on the team who did no work is gonna get the pat on the head, the gold star, yeah, and you know, all the credit. And you're like, dude, it was me. Yeah, exactly. What are you talking about?

SPEAKER_01 26:05

It's like if you're gonna do something like uh filler, PRP, Botox, laser, the same thing as Sam sperm, salmon sperm is the uh lazy one in the group. Yeah, you're not gonna get results from that. And the results that you do have are gonna be from doing all the other four treatments, not the one that failed every trial.

SPEAKER_00 26:27

Right. Do the one that's like, are we done yet?

SPEAKER_01 26:31

Yeah.

SPEAKER_00 26:31

What are we doing here today? And while we're all like working away like little mad hatters. So if anyone's wondering why we have this picture up, it's also to dispel as a reminder. I could I it I wouldn't be me if I didn't remind everyone of some of these other trends that were so hot and so popular at the time.

SPEAKER_01 26:48

Oh, let's go through them.

SPEAKER_00 26:49

Do you remember the bird poop?

SPEAKER_01 26:51

Yes, this is very old one. Yes. Um before I started even doing any like cosmetic shit. Um I never got the idea of putting shit on my face as being some form of anti-aging treatment.

SPEAKER_00 27:05

Right.

SPEAKER_01 27:05

Well, there is Unless you have some fucked up scat fetish. I really don't get why one would want to do that.

SPEAKER_00 27:11

It was, oh my god, it was very specific to a certain group of birds from a certain source, uh, if I remember correctly, because this is old, and the bird poop, I believe it was like chalky. So it made you look like, you know, like when you take a Kalen clay mask, you went, ooh, I see something. But it was bird poop at the end of the day, and it came and went as a huge trend for a reason. Because it was, it was like it wasn't bullshit, but it was bird poop.

SPEAKER_01 27:40

Well, 10 years later, we have more bullshit, except from down under with uh cod.

SPEAKER_00 27:45

Right, exactly. So that was one. Um, and also the bird poop when it was happening, when it was trending, reminded me of like back in the 50s and 60s when um poor kids that were experiencing a lot of acne were told to rub dog poop on their face.

SPEAKER_01 28:03

Who comes up with this?

SPEAKER_00 28:05

I don't know, and and kids everywhere tried it because they were desperate for relief. And I'm just like How many got E.

SPEAKER_01 28:11

coli infections?

SPEAKER_00 28:12

This I know that there was no tracking of that stuff. And oh, there's no well, there might have been tracking, but there's no official reporting about that stuff back then, so we don't know how many people really suffered a massive negative response because they were rubbing dog poop, and maybe it didn't even stop there, right? And by the way, I don't have a feces fetish, but while we're on this subject, maybe the bird poop or the dog poop people didn't stop there. If it didn't work, maybe they tried cow poop or cat poop or right?

SPEAKER_01 28:39

You really don't know what the people where did it stop?

SPEAKER_00 28:42

Like we don't know where it ended. So thank God though, the bird poop is coming gone. Bye. And then enter this was another huge one, right? This the um snail slime.

SPEAKER_01 28:54

I actually really don't remember this. These must be like from quite some time ago.

SPEAKER_00 29:00

So there's um snail, there's also like snake venom. I forgot to put up a picture of the snake, like maybe I could have done a magic.

SPEAKER_01 29:07

You know, I've read about certain snake venoms being good for cancer. I know in other countries that they've done treatments like that. Right. But um what the hell were snails doing for the face?

SPEAKER_00 29:17

So the snail slime and the snake venom. Snake venom in particular was supposed to be like a neurotoxin.

SPEAKER_01 29:23

Okay. And how long did that one last?

SPEAKER_00 29:25

It's not. It's like here you you might have looked great for a day or two or three, maybe a week for some people, and that was it. So there's nothing like a neurotoxin. I can't stress that enough. An antifiller girl, unless it's your lips, but there is nothing like a neurotoxin, not surgery, not soma cell, not laser, nothing like a neurotoxin, not snail slime. Just stop. Just please stop. There's nothing like a neurotoxin. Nothing is going to interact as quickly and as definitively as a neurotoxin. And some people are like you, they might have to try multiple before they find the one that works.

SPEAKER_01 30:00

Yeah.

SPEAKER_00 30:00

But it when it works, it works. And there's no question about it. So this so there's there's still a lot of companies product-wise, topical skin product-wise, that will have like some snail slime in it, uh, snail, whatever derivative that they're using in the ingredient, along with a host of other ingredients like we talked about before, yeah, to help with uh nutrients and like beautifying your skin. If it doesn't hurt, it's not gonna be harmful, fine, it's in there, but I personally would never go out looking for just you know one of these snail slime treatments, uh, or using bird poop, or and particularly not using PDRN. I the for me, it's not even juries out. For me personally, I'm against it. If you want glass skin, if you want anti-aging, if you want any kind of, even on a temporary basis, something that's gonna last longer than 24 or 48 or maybe 52 hours, we have a host. As you've pointed out, well, we have a host of things that will work with your body properly. Uh, some of them are non-invasive and not harmful or painful like somacelle, but there's so much more out there that you can do without wasting your money. And that's my bottom line. When it comes to salmon, eat it, admire it, or have it in a pond. Or, you know, do they even grow in ponds actually? I think they have to be out in free water. Yeah. I'm not I'm not into salmon forming.

SPEAKER_01 31:25

I mean, you know, it's so hard to right now to get food that's not genetically modified. Right. So if you are able to get salmon sperm instead of cod sperm, who's to say it's not from a genetically modified form?

SPEAKER_00 31:45

Exactly.

SPEAKER_01 31:45

You know, like there it there's just so you really need to look into this, and the fact that it hasn't proven promising in studies, uh, I don't think it's worth it at all.

SPEAKER_00 31:55

Right. So, like we talked about before, to totally recap it, is it salmon or cod? And then if it's salmon, is it genetically modified? Is it from a salmon farm which is proven to be rampant with disease, which they have to be bombarded with antibiotics, which is proving to be detrimental technically to human health when we're eating too much of that.

SPEAKER_01 32:17

Yeah. That's why people, when they want burgers, they want to make sure it's like grass-fed, antibiotic-free. Right. Same with chicken. Right. You know, and the same goes for, yeah, and salmon too.

SPEAKER_00 32:27

Exactly. So, you know, now we have all those problems, but then take it the furthest step, which is how is it being processed? Because, like we said at the beginning of the podcast, any sperm is very, very heat sensitive. So, how, if it is salmon and it is salmon sperm, and you're trying to DNA fragment this, how are you getting to that conclusion?

SPEAKER_01 32:50

Yeah, what are the regulations?

SPEAKER_00 32:51

Yeah, so is it even efficacious once that DNA has been fragmented? Because how do they fragment it off of that DNA? And then, as you said, and you know, I keep bringing we both keep bringing it back, there's no clinical evidence from anywhere in the world, almost two years into this trend, proving any kind of efficacy whatsoever. None.

SPEAKER_02 33:11

Yeah.

SPEAKER_00 33:12

So there you have it. So as far as I'm concerned, eat it, admire it, don't inject it in your face.

SPEAKER_01 33:19

And it's a no from me. I'm putting it in the same category as R microneedling, VI peels, bird poop, uh, bird shit. And what the fuck else am I missing that I tried and I was not happy with? Well, that's a sound.

SPEAKER_00 33:36

You said oh, and the opus plasma because you said it was way too painful.

SPEAKER_01 33:40

Yeah. No, no, and no.

SPEAKER_00 33:42

Right.

SPEAKER_01 33:43

There's a lot more successful things you could do.

SPEAKER_00 33:47

Absolutely.

SPEAKER_01 33:47

Do a day of regenerative beauty like I did. Get somacell, get toxin, get microneedling with PRP. You'll have a longer lasting effect than you will by investing in a series of salmon sperm.

SPEAKER_00 34:00

Right, because now you're taking individual treatments that are all been clinically proven on their own. So when they're put together, they enhance each other for an even better effect. And that's, you know, if you're looking for more than a singular treatment, uh, that's definitely something that you want to look into. Always make sure it's it's a licensed and certified professional provider. And I don't mean, you know, a license to drive uh a bus. You want a proper license for the level being represented of that provider to you. And you want to make sure that they have a lot of experience when it comes to each device that they're using, because not all lasers are created the same. Um, some of it sells great because it's not damaged. It's actually legitimate repair and regeneration that's been proven since the year 2000 for that technology. And when it comes to certain chemical pills, etc., if it's the right proven technology or product at the right amount of time, the right person, the right lifestyle, all these expectations, all these do and don'ts before and afters, and how do you manage that? If you understand that whole picture and so does your provider, you can get fantastic results at whatever level, whether it's no downtime, major downtime, or anything in between, whatever you want, you can work together to achieve those goals. But the quick fix with PDRN, please don't waste your money. That's where we stand on it. We'll update this podcast in the future if we get bombarded by new clinical trials that'll be coming out, right? Show me the money, show me the evidence, we'll come back and we'll share that with you. But in the meantime, it's a no and will. It's a no.

SPEAKER_01 35:38

And oh, definitely a no from me. Right. I just put it in that shit category. And all the other things that I tried that I did not like or see much of an improvement from, it's in that category.

SPEAKER_00 35:48

Exactly. So aesthetics unscripted, you can follow us at Soma Cell Skin and at ITXmagic and Soma CellSkin.com, itxmagic.com, and will please like, follow, subscribe also.

SPEAKER_01 36:04

Will love listen on iHeartRadio or anywhere you get your podcasts, and follow the podcast on social media at willlovelisten and me on social media at willlovinc. And also check out my articles. I'm the entertainment editor of that one jersey magazine. So, yes, follow me, read, watch, listen.

SPEAKER_00 36:22

So, inquiring minds want to know. We'd love to see your comments. Please subscribe, like, comment, and share. Aesthetics unscripted on YouTube.