Peptides & Thyroid: Optimizing Cellular Function And Avoiding Problems

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🎓 ABOUT THIS VIDEO 
In this episode, Nathan and Aubrey dive into the nuanced world of hormonal management, peptides, and supplements, covering compounds like MOTS-c, SLU-PP-332, and NAD+, thyroid medications from T3 and T4 to Armour Thyroid, and SGLT2 inhibitors for metabolic health. You'll learn how to sequence and personalize these interventions safely and effectively, understanding the complexities behind thyroid function, mitochondrial health, and drug interactions along the way.

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🧠 TIMESTAMPS
00:00 - Intro: hormones, peptides, and what's ahead
00:27 - Aubrey's last day on drugs, and cycle break strategies
01:19 - Maintaining cycles and drug use in the offseason
01:44 - Hypothesis: insulin sensitivity without being lean
02:10 - How pumps and growth relate to body fat
03:04 - Volume management and split training technique
03:30 - Building size and tracking progress
03:58 - Self-coaching vs. external coaching
05:18 - Best peptides for joint pain and inflammation
05:42 - Peptide dosing strategies for inflammation
08:01 - Load management vs. peptides for joint recovery
09:25 - Tracking pain and inflammation response
10:43 - Proper water volume for peptide reconstitution
12:13 - Mitochondrial supplements and peptide synergies
13:36 - NAD+ and sirtuins in mitochondrial health
16:14 - Synergy between MOTS-c, SLU-PP-332, and NAD+
17:39 - Thyroid meds, history, and risks of Armour Thyroid
20:02 - Overdose risks with desiccated thyroid
21:56 - Safety concerns with unstandardized thyroid supplements
23:02 - When thyroid meds mask underlying issues
24:36 - T3 dosing, timing, and managing missed doses
25:15 - SGLT2 inhibitors for prep and insulin sensitivity
26:02 - Combining compounds for metabolic health
27:20 - Practical peptide and drug protocols in prep
28:35 - Peptides' real impact, and why context matters
29:23 - Community engagement and ongoing learning
30:42 - Upcoming projects and a focus on self-care
31:29 - Enhancing mental performance with nootropics
33:13 - Compounds' multifaceted, systemic effects
35:42 - The danger of stacking conflicting peptides
37:06 - A systems-based approach to autoimmune conditions
41:07 - Debunking myths about neurodivergence and autism
42:47 - Individual differences and biological diversity
45:35 - Timing and sequencing new peptides
48:36 - Balancing multiple interventions without overcomplicating
51:53 - Peptide administration routes and stability
54:36 - Why T3 often beats T4 for metabolic optimization
56:28 - Limitations of T4 studies, and T3 safety
59:14 - Labs vs. symptoms in personalized thyroid treatment
1:02:16 - System-wide thyroid optimization
1:04:07 - When peptide stacking becomes counterproductive
1:06:36 - Designing a personalized, full-year peptide rotation
1:08:09 - Diagnosing hidden thyroid or adrenal issues
1:10:38 - Final thoughts: collaboration and what's next

Transcript

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SPEAKER_00 0:00

What is up everybody? My name is Nathan. If you have never met me before, but I'm pretty sure you've met me before because like 90% of the people listening to this podcast are people that fuck with us pretty fucking hard. And today is Wednesday, and you know what happens on Wednesday? I welcome everybody to another episode of The Opticast with me, Nathan. And me, Aubrey. Where today we're answering client questions. Bunch of client questions specifically about thyroid drug supplements and stuff like that. So the stuff that you guys actually enjoy talking about, it is Aubrey's last day doing uh last week doing drugs, last day doing drugs today. Actually, as a matter of fact, I was even thinking, like, hey, why don't we just uh push for another two weeks and then we just deload you at the beach and just pull it off? Like never I haven't I haven't even bounced this idea off of you, but it's just something that I had in mind. What are your immediate like thoughts of it? I know you probably need like 72 hours to process it all, but like immediately, like what what jumps in?

SPEAKER_01 0:53

I'll honestly do whatever you think is best. I d think that a break from the drugs is probably a good idea. If you're planning to put me back on cycle in a little while. So yeah, I think I'm probably ready for a break from the drugs.

SPEAKER_00 1:08

Yeah. So yeah, it made me very, very happy that we didn't lose our cycle at all. So not only are we able to regain cycles at Optalab, we are able to maintain your cycle while you do drugs, which is uh pretty fucking cool and pretty unheard of. So I'm very excited to do that.

SPEAKER_01 1:22

Keep your cycle during your cycle.

SPEAKER_00 1:24

Keep your cycle during your cycle. That's how we do it, dog. Fucking Optilab, you know what I'm saying? Yeah, and I am in my uh second week now doing doing drugs. Uh feels great. I feel pretty good. I am approaching 210 pounds. I was like eight weeks ago, I was uh significantly slimmer than that. But uh, I am growing and I I have a theory here that I'm uh validating. Well, I have a hypothesis that I'm validating, and my hypothesis is that you do not need to be lean to be insulin sensitive. Seems pretty natural, but every coach and their mother makes everyone lean first before starting to push. I've decided to not make myself lean and to actually let myself get a little bit fluffier and then run it and then uh restore insulin sensitivity while being in a caloric surplus, reduce inflammatory markers while being on over a gram of gear, which is like what the fuck? Like that's pretty like hard and challenging to do. But if it works, I'm gonna let you guys know in about uh a few months. If it works, then now we'd literally fucking crack the code and we have the formula for uh making anyone grow regardless of their body fat within a reason, right? So I'm pretty fucking excited about that. Uh my pumps are are great and kind of ridiculous to be honest, like just hurting so bad. I did hamstrings today and it was just like fuck like painfully, um, yeah, painful, painfully so. But like I'll get to like third or fourth set of a body part and I'm like almost done. Like I can't contract it anymore, I can't like let it stretch anymore, it just feels like nothing, just feels numb. Some body parts are different, but on Instagram I said, you know, whenever you find that limit, now you need to start playing with frequency to get to get to your volume, you know. So if you can do I'll do a max of like good quality, like four sets, then four sets is the max that you do. You don't go for 12 because that's just junk. So what you're gonna do is you're gonna split that 12 sets into three sessions, you know, and then you're able to uh get the same amount of volume with with like full like quality stimulus from the beginning all the way to the end. So I've been sort of doing that with myself. Like for chest, I can push like six to eight sets. For hamstrings, it's like six sets as my max for quads, like four or five sets. I'm fucking wiped out. Biceps, like three sets, triceps like six. So it really does depend, like per body part. I could probably do like a hundred sets of lateral raises, but uh, I've been having a blast here growing. It just feels so nice to like finally see the weights moving up again and see myself getting bigger. Like yeah, it's been uh it's like almost half a year like doing nothing, just like waiting, just like working and and shit like that, and then now just being able to grow again. I'm excited. I wish I had spent the whole year growing, but it just wasn't possible. But um, yeah, next year it's already mapped out until next year because that's how we do it at Ops Lab. We map out everything for the client. So I thought I'm gonna map it out everything for myself because I coach myself. And I'm like, shit, like if you're an attentive listener, you already know that I had hired a coach uh a while ago, but that is uh no longer the case. I am back to coaching myself for reasons that I will not get into in the podcast because I really respect the coach that I was working with. Um, but it's just uh for my personality, for the moment in time that I'm living, and for the amount of uh attention to detail that I want, and uh also for being an experimenter and wanting to run experiments and things like that, it just works better when you're managing all of that in-house. Uh, you know, now this is not a recommendation of what people should do. I probably will still hire a coach before I step on stage. Uh, but it's just uh something that I've been uh been working on. But it's like when whenever whenever I start talking to people about like my process and stuff like that or training, the like I feel like people are mostly interested in just talking about drugs. And uh today we have a bunch of questions about those. So let us start with the first client question that we have received, and you guys get a little bit of a sneak peek into the stuff that I've been uh talking here about um uh with my clients. So just giving you guys a little bit of free sauce here for this Wednesday. So uh what's the first question here, Albert?

SPEAKER_01 5:10

What's the best peptide for joint pain?

SPEAKER_00 5:13

All right, so let's break it down. What is the issue with joint pain? Is it because of the inflammation? Is it just because of like actual morphological changes that you have? Or is it something that like you're dealing with with like some tenderness and you just need to push through, regardless of inflammation or not, just being able to like train and continue doing your stuff because you have a world championship coming up, like real story that that does happen, right? So it depends on what you need, right? So I think that depending on what issues you have, the usual TB500 and BPC 157 are gonna be great. If you have a lot of inflammation, KPV is gonna be great there as well. Also, JHK Copper just having it in the mix as always is gonna be good for those DNA changes. And one that I don't really hear people talking about is called Pentadeca Arginate. So PDA. Uh PDA is a fantastic one that I've been out. I was put on in this like fucking eight years ago, something like that. I don't remember, but it was through Leo and longevity, uh, when he was talking about like the uh all the stuff that can make your joints feel a little bit better and stuff. Dude, it's like it Deca, it doesn't even compare. Like the lubrication and stuff that you get, PDA is like you inject it in the morning, like a few hours later, you have no more pain. And it stays that way. It improves your range of motion, like absolutely everything. Negatives hurts like a bitch and possible ocular uh degeneration, because apparently there is a uh now this take it with a grain of salt and I'll explain why. But the the theory is that there is a certain amount of eye damage that your eye will take with every dose. So once you cross a certain threshold, is just you now have permanent eye damage, okay? Leo had the same theory about Kaber, cabergaline, um, that for us to reduce prolactin, we should opt for P5P because uh kabergaline is actually going to cause a fibrosis in the heart eventually, and there's no way to escape it because you just crossed that threshold. Problem is when I look at the evidence, I cannot find that shit whatsoever. Like, I just have no idea where Leo got that from, and well, I can't ask him. So, like, I I uh I take that with a little bit of a grain of salt, especially with KBR. I because I used to think the same thing, but the problem is like the doses for KBR that you do see heart problems in, they are not doses for reducing prolactin. Like they are the dose that we use for actual medical use, and they are like dozens of times higher than the doses that we take, which is just makes it unaffordable for most people because we're taking like a quarter to an eighth of a tablet like a couple times a week. It's not even like an everyday thing for a lot of people. So um, would I still prefer to take B5P? Yeah, if your B6 levels are good, like I found out that my B6 levels were like very fucking high, like double the reference range, which is a huge problem for nerve degeneration. This is actually validated. So it just depends on the context of their like what you're looking for. But like if you are someone who's working on elbow issues, right? First of all, I would read my free book that's in the description here on Obal tendinopathy because it's applicable for everything else in terms of volume management and the stuff that's really gonna move the needle for you to recover well. Um, but then number two, start with the foundation. Like the foundation is gonna be volume management and load management. The third thing that I would have in place is like actual like progressive overload, just understanding how to progress uh in that, and then the stuff that is like really gonna be helpful, like your food, as well as supplements like curcumin and things like that. And then I would look into the peptides. So like it's surprising to a lot of people, but like when I hear a client saying, like, hey, I pulled my hamstrings, I don't immediately go like glow every day, one milligram, like I don't do that. Um, I think there's other levers that are stronger. So I use BBC and TB and GHK, like if it's needed, to the point that I find it to be beneficial. PDA, if you have like a big match coming up, a big event, or you just like have like three weeks to end your push phase and you just want to push through or something like that, could be useful, right? You just have to understand that you are putting a bigger hole in your bucket that you're gonna have to patch later on. So you're creating more debt and you're gonna have to pay for that bill at a certain point. It just uh there's no free lunch, so to speak, right? You can't just uh manage that. But like honestly, for for joint pain, the biggest needle mover is going to be load management. So you don't want the pain to be there at a level higher than it was before. So you measure with your level of pain before the exercise, then during the exercise, immediately after the exercise, the day after, and then two days after. You want to see it declining. Even if you cross that threshold of like four to five out of ten in pain, if it does decrease and it progressively keeps like the gap keeps widening, you are making progress. So this is one of the things that like as a coach I do for my clients. But if you're gonna do yourself, you just need a lot of pen and paper and a lot of uh forms and stuff like that to just be able to track this stuff here for yourself. But yeah, you never really dealt with like joint pain and stuff like that, right?

SPEAKER_01 9:39

I have with my shoulder, and but it's a lot to do with my back issues. So if I foam roll and I stretch out and I hold a lot of stress and tension, so anytime that I'm going through like a stressful period, you know, I get all tied up in here. So I just have to foam roll and actually fix my back and my rib and my back. And if I do that, then my shoulder issues go away.

SPEAKER_00 10:06

Yeah, I love how she's like, if I as long as I fix my rib and my scapula and the muscles underneath the rib and my back, then I'm good. And I'm like, I have no fucking clue how to do that.

SPEAKER_01 10:15

It's not really I mean, I don't know fixing, but I like uh I have some some specific stretches and massage techniques that I do, and it seems to keep it in check.

SPEAKER_00 10:26

So Massage. Le Masson. A little bit of French going on. Alright, what is the next question? How much uh BAC water do I order with peptides? It's pronounced backwater, bacteristic water. So how much do you order? How much ever you need, bro? Like the thing is you you dude, the the the amount of backwater literally doesn't make a fucking difference. Like if you if you struggle with that whatsoever, inside of the engine there's a calculator for you to use. But it's just like assume one CC for every vial. So if you buy 10 vials and need 10 cc's. Fair assumption. Like if you have something that's 15 milligrams and you want it to match perfectly, then add 1.5 cc's of water per vial. You want three cc's of water in there because of like uh the clouding and stuff like that, like happens with MOTC? Sure, put three CC's inside. It literally, the amount of water is completely irrelevant. It just tells you how much you're dissolving. What you guys don't understand is like just take it in a cup and put 20 grams of sugar, okay? And now somebody asks me, like, hey, I'm trying to eat 10 grams of sugar. How do I make sure that I only eat 10 grams of sugar? I'm like, put however much water you fucking want and drink half. How can you do that math with sugar in the cup? But as soon as the sugar is inside of a vial, you're like, uh fucking don't know how to do anything. My fucking blue screen Air 404 on the screen, just boom, you know, like it doesn't, it doesn't work that way. So I won't spend much time on that question here.

SPEAKER_01 11:47

The synergy between the mitochondrial supplements and the peptides, like MOTC, NAD plus, SLU, that why they need to be combined to work effectively.

SPEAKER_00 11:58

Okay, so uh the person is pretty much asking me, like, hey, what's the rationale behind every item in your mitochondrial protocol? Uh, to which I'm gonna answer there is a lecture for this particular protocol inside of the OctoLab Engine. It's called the Pre-B Growth uh stack. And uh, you should just watch it. And if you want like a another breakdown of it, you can watch my part one of the conversation that I had with Anthony Castor and the DDT with Drew Jonathan's uh podcasts, also broke these down. But there's a different angle that I also wanted to uh to cover here because Mont C, NED Plus, and SOU, they're sort of all pushing on the same four man, which is PGC One Alpha, right? The thing is like PGC One Alpha is going to have two locks behind PGC One Alpha. So Mod C is sort of like turns the first lock, which is gonna trip the AMPK alarm, and AMPK is gonna tag the four man to switch it on. So the PGC One Alpha starts, but that is only the first lock. The second lock is gonna get turned on by the Sertuans. Sertuans are DNA uh cleaning up crews, right? So uh they're kind of like who's gonna pull the muzzle off of the four man so he can actually shout the orders, and the Sertuans can all work unless there is energy for them. If so, therefore, if you have no NAD plus, you get the second lock stain shut, right? So the foreman is gonna be activated by the NAD plus. So when you bring NAD plus, the the batteries are gonna charge, so to speak, inside of the mitochondria. The crew sort of wakes in and the second lock has gone away. So the SLU has been outside basically screaming for the build signal to be there like this entire time. So you've got Mod C turning one key, NAD plus turning the other key, and then SOU pretty much like handing the work order for your mitochondria. Like none of them works like on its own to fully switch PGC1 Alpha. So that's the thing, that's like the convergence of all of them. But on the other end, you also have like pretty much like the uh one of them is building the factory, so like uh SOU is building you like 30 different mitochondria, right? Except 30 cold furnaces are sitting there doing absolutely fucking nothing, so you need a charge. So NAD Plus is that charge, so you get more furnaces with SOU, you get the power for the actual furnaces with NAD Plus. And then, like when SOU is going to be like it has the like, okay, SOU build more furnaces, right? Great. Now the same four man also needs to build little battery like charging stations inside of those furnaces so that the house can make its own NAD Plus and it doesn't depend on you just injecting NAD plus every single time. So the NAD plus has to scale alongside with what the SOU is building. So like building capacity and charge supply capacity, they have to be combined together. And Mod C then is gonna be the guy who's running down the row, flipping all 30 furnaces on and then shoving the NAD fuel at them, right? So it's a three-part chain. The SLU builds, the NAD Plus powers, the Mod C Mod C is going to uh switch it on. And at the same time, like if you want to like just consider the last point here, is that like NAD Plus is gonna be sort of like uh suppressing the fire that's gonna let you run the other two things hotter without burning the house down, right? So when you run like all of these 30 furnaces that SOU build very, very hot, and you get them like turned to the on position at all times with Mod C, you're gonna throw off a lot of sparks. And those sparks are reactive oxygen species, which are oxidative stress. If you have too many sparks, bad things are gonna happen, right? So NAD Plus, because of the Sirtuans, it's literally the sprinkler system and the cleanup crew. So the the charge batteries, they're gonna let a very specific part of the sirtuan crew actually like run the fire suppression portion of things, and then that's going to be turning on those built-in extinguishers and keep the fired furnaces burning clean without causing problems. So the NAD Plus is also not just powering the furnaces, it's also the safety system that's gonna let you run these things uh without tripping the breaker, so to speak. So they're very much synergistic. And there's there's like these are just the three angles that I have like in my course. There's a fourth one that I just published last week on um with five amino 1MQ, is there? But you have to understand like how these things work uh sort of underneath the hood and then just play with their roles because their roles are multifaceted, they're not just doing one thing. So when people are like, oh, it turns PGC1 alpha, great. I'm like, well, how many things need to turn PGC one alpha? Because it's not just one thing. So it's like the same thing with nootropics, right? It's like, oh, this thing like makes your uh serotonin receptors more sensitive, or or like it traps the serotonin receptors so it keeps recycling in there and like raising the pool of what is in the serotonin receptors. I'm like, really fucking cool. But what if we could just build more of those and make them more sensitive, right? So, like, what's the tool that's gonna allow me to do that? So that's kind of how I'm rationalizing and thinking through these compounds because they're like uh they have multiple arms, right? They're touching multiple things at the same time. Some things they touch very, very hard, some things they touch very softly, and it just like doesn't have a lot of consequences. Certain things, when you mix these two, it becomes a no-no, uh, right? Like, for example, if you have the MOT C in the SLU, but you don't have a lot of antioxidant capacity, it's like you're kind of gonna start creating some problems with redox balance, right? Now, what if you're just like setting up insulin sensitivity with MOT C, but you're actually never actually solving the issue because you just have an alternative GLUT4 door, right? So you just gotta like think about these compounds in this uh direction. I think it's much more useful than asking in terms of like, what's the synergy? Well, it depends which angle you look at it, right? You could have synergy from like four different angles that I just presented here. Um, so it just depends on like what you are trying to get, which is why like your protocol may be the exact same as someone else's protocol. It may look exactly the same, but what it's accomplishing is something entirely different because of your system. So it's kind of like if you have like five receptors and uh there's three of them that are the priority, right? This protocol is gonna tackle this three. But for the other guy, maybe it's just these two and it's gonna tackle these two as well, just from a different angle with the same exact compounds. Now, second question here that this person asks Tesamoraling, Tesamoraling overview, if not already in there and how to use it. It is already in there, so go watch it inside of the Otflad engine, but yeah.

SPEAKER_01 17:46

Does armor thyroid have a place in anyone's protocol?

SPEAKER_00 17:50

Massive fucking question. Uh, because it's uh it's uh it's it's complicated, right? So what is armor thyroid? Armor thyroid is desiccated thyroid, right? So it's having both T4 and T3, which is great, much better than T4, right? And if you go back to the first instance of hormone replacement therapy as a whole, not just thyroid, that happened in 1891 with a guy named George Murray. Uh, George Murray injected a crushed extract of a sheep's gland inside of this woman who was, I think, 46 years old. She was dying of myxedema, and uh, she ended up to live until like 70 something, is the first time that we reversed the death sentence of myoxedema coma. So very, very interesting. And it was the first instance of hormone replacement therapy, and it was also the first instance of thyroid replacement therapy, which happens to contain both T4 and T3. Once we build the TSH molecule and uh the test, the radioimmonaassay, which got Young Love a fucking Nobel Prize in the 1970s, and at the same time in 1955 when armor thyroid came to place, we sort of like started to see that there are some issues with armor, right? So um, what is the issue with armor? First of all, armor was the once they realized that you needed like a pig's gland to be able to make it, uh, it wasn't a pharmaceutical company that started thyroid hormone. It was actually a slaughterhouse. So they had access to a fuck ton of uh thyroid, uh, well, of thyroids because they had an access to a bunch of pigs. So they started slaughtering those and and then crushing those and then putting them in uh pills for people to take them because Murray had already learned that we didn't need to inject people, it just needed to be present in the blood based on a guy that was kind of like a fraud and that uh tried hormonal therapy subcutaneous with uh an extract of the gland a few years ago uh before Murray. Uh very interesting story, but I I won't bother you guys with the with the details. Uh, if you want more details on the history of the thyroid, you guys already know you know where to go. But in any case, uh so what was the what happened in the 1970s once we had the TSH test? Because armor thyroid, right? Desiccated thyroid or NDT, it had the fantastic effect of uh bringing people back to life. So it literally saved people uh for the next like 50 years or so. It was fucking insane. Problem is once we started, uh once we had the TSH test, we noticed that a lot of those people were running extremely hot, and some of these people were running extremely cool. In other words, this was overdosed as shit. Why is it overdosed? Because you cannot escape this. A sheep gland and a pig's gland has a concentration of T4 to T3 of about four to one. A human being's 14 to 1, which means you are getting significantly more T3 out of the desiccated thyroid. Also, you can't control that because the gland is not even. It's kind of like when you're making edibles at home, you're like one is gonna have 10 milligrams, the other one is gonna have 45, the next one is gonna have three, and then you like split the three in half, and you're like, oh, I fell nothing, so let me just take a full one and now you just ingested 45 MIGs. So if kind of that happens, people are like, oh, but that doesn't happen nowadays. Uh, literally on uh January, February, March, uh March 18th uh was the last update on the web on the FDA's website. They're trying to like bring this shit back. Why? Because armor is not a medication, it's actually an unregulated supplement. Uh why is it an unregulated supplement? Because of this thing called the Grandfather Clause from 1938. But basically, these compounds don't need to prove safety and they don't need to prove uh standardization because they were made before that. Lithium is another good example of this. So uh they're trying to take it off the market because, like just as of I think last year or two years ago, we had another recall where people were taking hundreds of milligram of micrograms more of T3 than they should be, which is putting people in thyrotoxicosis. So all of the negative effects that people complain about, they're not coming from just people taking T3 from a pharmacy. They are literally coming from people taking desiccated thyroid compounded T3 as well as gray market T3. Every single one of them, just look at all the Bianco papers, is just very, very consistent. So is there a place is there a place for people? Yeah, like rescuing them from the in the beginning, whenever like they're on T4 monotherapy, which is garbage. So it gets that part right, but you can't escape the ratio, you can't escape the overdosing, and you can't escape the fact that it's unregulated, and there's literally the only people who are verifying the quality of this are the people fucking selling it, which uh multiple times in history we found these compounds to be significantly overdose. It's not just that, like supplements as well. Like people are just like, oh, let's just take some thyroid supplements. I'm like, motherfucker, selenium caused there was a a selenium batch that was recalled in 2024 that. Had uh, I think 200 times the amount of selenium that you should have, which caused a bunch of people to go into selenosis, which is a toxicity from selenium. It can happen. Uh, the same thing happens whenever you're taking uh, I think it's methymazole, PT, uh, right? When they're taking that, it contains about 75 milligrams of iodine, which is really, really good uh if you need to like shut down a thyroid. But the problem is if you're ever had an overactive thyroid uh with an autoimmune condition, that iodine flood, the system is not able to rebound from it and to absorb that shock, so to speak. And uh you just end up lightening up the fire that was you literally throw throwing gasoline in the fire of an autoimmune disease. So the concept is very important. This is why I tried like, well, with iodines, I I prefer to go with salt, with selemium. Let's try to go to Brazil nuts. Yes, I changed my mind. And uh, when it comes to uh thyroid, uh, why don't we just use a regulated thing that has been proven to be safe by Bull in 2025 and by Bianco's group in 2026 in the largest data set in human history for thyroid uh thyroidology, right? So do I see a role in people's place? Yeah, to rescue them in the beginning. But once they learn that you cannot escape the flaws that are built into armor, no, then I don't think it has any use for people uh in any way, shape, or form anymore. Yeah. Do you have any any thoughts or anything on thyroid and stuff?

SPEAKER_01 23:12

Nope.

SPEAKER_00 23:13

Okay, cool.

SPEAKER_01 23:14

What should I do if I miss a dose of T3? Take double the next time?

SPEAKER_00 23:18

Uh don't take double next time because you are going to double the peak of the drug, which means you're gonna double the effect of the dose. Now, don't don't be one of those people that's like takes the T3 and is like, oh, I get heart palpitations like an hour later. No, you don't. It takes like two and a half hours for it to peak in the blood, and the peak in the effects are decoupled in the pharmacokinetics of T3. Therefore, you're gonna feel the effects like five and a half hours later. Also, the heart palpitation is not a sign of heart damage. We literally tested this in both mice cells and humans, and we don't find that happening whatsoever, primarily because T3 has and uh has uh an effect of lowering collagen synthesis in the heart, which is why when people are dying of heart failure and their hearts are really, really compromised and you already see fibrotic tissue building in the heart, you get T3 in the hospital. If it was bad for your heart, no one would give it to you. However, some people will experience uh effects that can put them into thyrotoxicosis state, right? So if you double your dose, let's say you take 25 MIGs twice a day, like me, 25 mics uh twice a day. If I were to take 50 mics once a day, well, for me, I don't experience any side effects, but for a lot of people, that could actually throw their heart out of rhythm, which is going to be the beginning of something that's gonna feed into atrial fibrillation. So I don't see the benefit of doing that. If you miss the dose with T3, if there's another time to take the dose like an hour later, gated from the things that need to be gated, four hours away from the minerals and and an hour away from everything else, then do that. But if you can't, just whatever, dog. It is what it is. You're not like just try to be more consistent next time, so to speak, and put your T3 at a place at a time that you can actually take it uh pretty consistently. Yeah.

SPEAKER_01 24:47

Do you ever use SGLT2s?

SPEAKER_00 24:50

Yeah, so sodium glucose co-transporter twos. Uh these are, I I I think they're really, really good for a lot of things, but the the use that I see for them is uh primarily in prep or in a falosh phase because something like a 100 megs of canagloflosin is going to uh reduce your uh it's gonna literally make you piss away about 300 calories worth of glucose. So if you don't want to decrease someone's calorie again, hundred mix of that, and you're kind of good. So it has a really good effect on that. It's also gonna be good for your lipids, depending on your context of your lipids, because you don't want to crush them, right? Uh, but I do use them uh and I think it's useful for them to be used during prep. I don't see the use of taking them year-round, though. Uh, and I'm I'm taking it right now because it's good for insulin sensitivity and also because it buys me a few more calories of a worth of wiggle room. But I find that the effects are not so much of like, well, you're taking canagloflose, and so now you get to eat 300 more calories and maintain your weight. I don't see that happening. I see my weight going up if I increase it by 300 calories. What I do see is better, like um my uh my insulin markers, they literally change in a matter of two weeks. So I've decreased my glucose was 100, it went down to 80, 83, I think. And my insulin was 6.8 and it went down to 3.7 in a matter of 18 days. Now, I was not just using canagloflosin, right? I also had 5 amino 1 MQ, SLU, T3, which is fantastic for insulin sensitivity, right? Because it literally built Glute 4 doors and also like sets how sensitive they are. Don't have a MOT C in place right now because I just don't think it's needed. Uh, but I do have other things like berberine and uh some 5 LOX inhibitors and a bunch of other like cool compounds in place that are working with the inflammation as well as with the uh insulin sensitivity, and I see a good, good uh effect on them. But I don't use it a lot, and I don't use it with a lot of people. And I do find that some people end up looking a little bit more deflated. So, like when I'm when I have someone in prep who's running this, they're gonna look a little bit more flat, which is gonna end up with like them looking a little bit fatter than they truly are. So it's like you look like 10 weeks out, you kind of look like 14 weeks out. But like as soon as we feed you and we like pull the canagrophones out, we pull the SOU, pull like whatever else we're running, you just fill up very, very fast. So I like to have it like in the middle of my of my preps, so to speak, whenever we are in the tail end, because I bring my guys ready like several weeks before the show, like several weeks. I'm not talking like two to three weeks. I go, I want to have my guys pretty much ready like six to eight weeks out. Like if we were to step into a regional show, they could take it, honestly. And then it's just gonna be refining details up to that point, right? Now, some people cannot tolerate to be like maintain that level of execution, adherence, and uh restriction, as well as like energy levels and all these things for that long. So for those people, I'm gonna push it a little bit closer to the show, but I don't run Canagua flows and all the way uh to the show. I mean, I have, but I I in generally don't, unless I'm like just trying to modulate the uh like if I'm trying to nail down the the the calories specifically and that's 300 cal of glucose coming out as like really not doing its job. Um, but in general I pull it out because I want the glucose to be retained into the tissue, which is one of the reasons why I use uh fats in my loadings as well for the majority of people. So I do think they have a place. Um and it's actually interchangeable between the the glyflosins, so to speak. Uh impagloflosin, canagloflosin, uh whatever the fuck the other ones are called, they're all called glyflosins. But it's like I think it's 25 megs of uh impaglyflosin to 100 megs of canaglofosin. I don't remember off the top of my head, but there is a conversion charge which I own. I just uh I never publish anywhere. But if you guys wanted uh more information on the flosins, uh let me know because I find them to be very interesting drugs, and honestly, I'm not as well versed in them as I am with T3. I mean, I'm not even verse well-versed into uh who the fuck I am and like who the fuck is my wife as well as I'm versed in T3, but uh that's uh I still have this uh ridiculous standard where I expect to know every single drug as well as I know T3, uh, which will happen. You guys are watching it happen. It's literally gonna happen in a matter of a few years, but uh it's uh I just wanted to say this actually, like it's really cool for for me to see like the effects of my learning into other people's lives. So like when I publish something on on Instagram or here of something that I learned and then something that I tested, validated, and bounced with other people and stuff, and you guys start running it, and then I see more people talking about it on other podcasts and stuff like that, regardless of the fact that no one ever gives credit to like where the idea comes from, because I think this just boils down to like not being an academic environment. So people are not like citing their sources, they're all just saying, like, hey, people are saying this, I think this, and people are saying that, and I say that, uh, which is why I think that it's uh uh we have it's so slow for us to make progress in this industry, which is one of the reasons why I cite papers and all this type of shit. But I just wanted to thank you guys for being part of my learning journey because it's also part of your learning journey, you know. Like as I start, uh, well, I have started, uh, but as I continue to learn more about peptides and the gut and and PDs and supplements, you guys are also learning about all of these things. So it's really cool to know that like I'm sitting down in my desk to study for like two hours. Dude, that's gonna change so many lives. And then I open Instagram, and there's like 40 fucking like comments and like a hundred like shares and eighty like reposts and all this shit, and then a bunch of messages from you guys just saying, like, man, I never thought about this, and this is really cool, and this makes a lot of sense and everything. I really like it, and I really appreciate you guys trusting me and everything and uh uh being involved in this journey with us. And uh in a few weeks we're gonna have some cooler things for you guys. Uh, I cannot fucking wait to share it, but I've been doing a lot of work. You guys know uh I had a call with someone this week uh who uh shout out Jen uh was uh is a very, very uh familiar with the podcast and the content and everything, just like fully immersed in it. I've absolutely fucking loved that because this is what I build it for, right? And on the call was just like, man, I was super tired this week. I crashed very, very hard and everything. And she's like, we could have told you that you're crashing. You've been complaining about being tired and like not being able to do everything, guys. I promise. It's only two and a half more weeks, and then just after that, well, two, two to four weeks, okay? Just two to four weeks, okay? More of that, and then uh we're gonna be back into a more chillax uh environment. And I'm really curious to see how my growth is gonna be uh once uh we have more time to uh breathe, you know, because right now, like every wakey moment is focused on clients and the people who are part of Optolab, uh, the engine and stuff like that, and uh the education, right? Um, and and consults and stuff like that is like it's focused on those things, and which is fantastic, right? And I'm gonna continue focusing on those things six days a week, but just one day a week. I just want to be able to focus on myself and just get a little bit of rest, you know, like pulling myself to do the pods and everything today was already like, oh my gosh, I'm so fucking tired. So we loaded up on uh phenylparacetam uh hydrolyzide, hydrazide, phenoparacetam hydrazide, 9ABC, some perizenthine, some uh Samax, which I'm trying a different uh Simax spray right now, and uh really, really uh looking forward to the to the to the experience here. Um, people don't really know this, but like in in terms of like high performance sports sports where you need a lot of like reaction speed, memory consolidation, and things like well, the memory is coming from elsewhere, but some max is absolutely fantastic. I don't know why people are not blasting the living shit out of SIMAX, but I also see like people are not blasting the living shit out of BBC of TB500, TB4, and I really see the benefits of those things, especially TB4. TB4, the AC SKDP sequence that TB500 lacks, it's literally antifibrotic. It reverses fibrosis, as a matter of fact, in the heart. It cannot reverse necrosis, obviously, right? Anyone tell you that it reverses necrosis, they they literally don't understand how necrosis works because once it's dead tissue, you can't bring it back to light. You're not Jesus resurrecting a part of the fucking heart, right? Unless you think you are. But um if you're if you're not, and if you're a normal human being like us, you could leverage CB4 TB4 for those effects, but the dose is significantly higher, right? Like people are using uh a few hundred micrograms, and I'm like, bro, it's like 80 milligrams a day for a couple of weeks and then 60 milligrams a day for a few weeks, and then you get down to like 10 to 15 milligrams a day for the heart issues. Very expensive, absolutely, but how much is your life worth? Because bodybuilders only die of one thing and it's their heart. So, you know, it's just like I like to have it in place. I don't have it in place for the majority of my clients because of cost. That is literally the only reason. But I think it's uh extremely beneficial. And I think all of these compounds are very context-dependent and uh very useful if you are using them in the right case, which brings us back to the SLG LT2s, uh, which uh they do have their time in place. It just depends when, where, and uh because I think there's literally more than one way to skin a cat, like whenever I'm building someone protocol, I I purposely try to build it differently than before. So, like if I know that, like, oh, this guy has Hashimoto's, we're in the very beginning stages, TPO is like right here, like uh TPO, Jesus Christ, anti-TG, it's like all of this stuff is like in place. This is how aggressive I'm gonna be. I'm gonna start working on the TH1 armed, TH17 armed right here. Uh, I just started like mapping things out, but I want I'm curious. So I want to be like, hmm, could I use something else for that, like for that effect, right? Could I train those T reg cells, the peacemakers, in a different way? Like, could I could I work on the zonnulin without without lazotide, right? Like could I make that happen? Uh, you know, there's confounding factors, right? Oh, this guy also has uh gluten sensitivity, uh, but he really likes eating out. So, like, what can we do? Can we uh work on a reversal of that condition? There's also IBS going on. It's like, okay, we definitely can reverse that, but which order are we gonna like I try to make every protocol differently because it's interesting to me, uh, but also because like every time that it works, I'm like, literally, dude, there is no protocol. Like every time that this happens and it happens almost every fucking time, I'm like, yep, there is no protocol. Like, there's a billion protocols that work, but it all depends on the person. And if you're able to nail every single one of those things down, you fucking made it. So the way that I see myself like attacking something like Hashimoto's, it's kind of like uh, you know, that that evil guy from Spider-Man that has like all the arms and stuff like that. I'm seeing the dashboard with a bunch of different buttons that need to be pressed, and I'm pulling as many arms as possible. My dick comes out just pressing a button as well. My nose, which is fucking massive, is just like hitting that spot, fucking Pinocchio ass nose. The fucked up earlobe is hitting there as well. Like I got every single hand on every part of the dash, which is why it fucking works, right? Where so many protocols that people are like, oh, I took selenium and colostrum and I still have Hashimotas. I'm like, of course you still have Hashimoto's. You try to fucking take over a country with like 30 soldiers. What the fuck are you doing? Like, that's not how it works. I just so fucking pissed I spit all over my screen. Uh, which damn, look at my screen, bro. It needs to be cleaned at some point. God damn. I was saying about my screen, my screen needs to be cleaned. You guys notice that this is organized? You didn't notice because the light is dark as fuck, but let me let me turn it on. Look at that. It's all my tiny little guns. I had a collection of guns. Why didn't I have a collection of guns? Because when I was really into guns, I've never been a collector, but I always like the idea of having a wall full of guns. Problem is, I don't really feel like spending the no three, three grand is a cheap gun, okay? You guys don't understand how competition shooting works. You're talking like open gun, you need three, and they cost at least $10,000 and they break at least twice a year. You got to replace every single one of those parts, which is like a grand. So, like having a full wall of these things, I gets really, really expensive. Now, if you want to just be a collector, fucking have at it. I never see the point of uh boasting about a bunch of things that I have, but I don't know how to use. I find it to be super weird. It's kind of like these people that uh come in constants and like, hey, I have access to like all of these peptides and all of these supplements. And I have I even have steroids. I'm like, bro, you're 73. Why do you have like steroids? It was like, oh, just in case, just in case. And I'm like, just in case, here's my address, send it to me. I will properly dispose of it, okay? But uh, yeah, so uh just the just let's just wrap up the conversation about drugs here and and context. But I do have a podcast with a very special guest talking specifically about the context of drugs. So you guys stay tuned because it's gonna come up on an interview on a Friday very, very soon. And also, thank you for the love on all the interviews. Thank you for the love on all the comments and everything. Like, literally, my heart is so full that my schedule is so full that I cannot even sit down to answer all of your guys' like questions and comments and everything. And you guys already know that I hate the platforms that we're in because like it literally doesn't show me every notification. And if I just like accidentally glance at it and an appraise refreshes, which Instagram does all the fucking time, I lose the comment forever. And I was like, well, I typed the response and now I can't even respond to this person. So I try my best to write people's names down and come back. You guys already know how it works. You send me a message, and three weeks later I send you a reply, but the reply is always there because I'm super fucking grateful for doing what I do and uh super fucking grateful to be able to influence your lives in a positive light. One of the most frustrating things that I had when I was in the space of religion was the fact that just by being a scholar, you are automatically pretty much against what every single person believes in. You know, it's kind of like uh every person is looking at the Bible from the lens of like, what can the Bible tell me? What's it's the love story that God writed just for me? Like it, I'm so special and I'm literally the center of the cosmos. And like, uh, what job should I make? What should I make for lunch? And like all of these ways. And like, that's not how a scholar looks at the Bible. So just from the lenses that we have, like without we even start talking, it's already disrespectful for a lot of people. With human optimization, that's not the case. You guys are willing to learn, you guys are like willing to be to be proven wrong, to like move in the rather direction. Well, there's some people who are not, they're very adamant about things that we literally don't know shit about. We have like four papers and people are like, this is exactly how it works. I'm like, shut the fuck up. But you know, like we don't, we don't know how shit works. But it makes me very grateful to be able to contribute in a positive light uh with my autism. Uh, it's just a very, very nice. And also, uh, just a side note here, uh, because I I have I've talked to so many people and I hear this all the time when people are like, yeah, maybe it's my autistic, maybe I'm autistic, uh, maybe I'm on the spectrum. Like, yeah, like uh I think I'm on the spectrum. Like people just toss that around. No, you're not on the spectrum, sweetie. Like you're just ADHD and you're unmedicated. So it feels like because there's a lot of overlap between trauma, depression, anxiety, autism, and ADHD. So unless you like really have been diagnosed with this shit, the only reason you're bringing up that you're like, oh, I think I'm autistic is just a polite way to say, I see myself as being a really smart person. When I say I'm autistic, I'm not saying that. I'm I'm saying like, guys, when I crash, dog, I need to turn off the lights. My wife needs to whisper around me. Okay. When I crash, my dog is the only thing that I want touching me. If anything else, including clothes, sometimes is too much. When when I'm overstimulated, bro, I can't fucking process your words because I'm hearing the fucking electricity in the room. I can literally fucking hear the light bulb. It's insane. So, like, if you're having struggle with that, if you've never like lost a bunch of important people in your life because you completely misread a situation because you'd lack the social skills, you're not autistic. If you if you never like had a conversation with someone who's like really, really important and you could even maintain eye contact, and then when you're maintaining eye contact and thinking about your facial expressions, you're not thinking about what you're like talking about. So the conversation goes to shit. So you can do one or the other, right? And I'm very authentic. Like uh if I have high energy, you guys see it. If I have low energy, you guys see it. If you're not like that, like I'm just like, you're not autistic, you're just using my disability to brag about your intelligence, which I find to be a pretty shitty thing. Uh, but I just wanted to uh add that in there because it's my podcast and we can talk about whatever the fuck we want. You were about to say something.

SPEAKER_01 39:38

Yeah, uh special interests. Special interests can range from a through a variety of mental disabilities.

SPEAKER_00 39:47

And and yeah, no, people think that, like, oh, because I'm very interested in peptides, I'm autistic. And I'm like, no, uh, you could be at HD, you could also have a high IQ, you could also just be a person who's interested in this thing. Like, stop pathal pathologizing everything. This is one of the biggest problems. And uh uh, yes, of course, I keep up with the with the major debates in the psychology world because I like to have these conversations with my therapists. The first six to eight months of therapy were literally just us talking about the philosophical foundations of the the approach that my psychologist has. Because it takes a lot for me to trust someone, which is why I explained everything to my clients, right? Because I I want you guys to be bought in. I want you guys to be like into the process with me. But I just needed to understand that one of the biggest debates that we have is that like we have basically gotten every form of normal human behavior, well, behavior that occurs frequently, and we basically pathologized it into a condition. And what people are or like, what we're pointing out in the literature is that, like, hey, the whole like neurodivergent and neuro uh well, it's neurodivergent and then uh holistic, I guess I'll call it. Well, holistic is non-autistic, so uh neurodivergent and then uh neurotypical. Neurotypical, that's the word. The the split is not clean because the neurotypical is not the majority, they are the minority because everyone has some degree of something. And that is not proof that everyone is a little bit autistic because there's no such thing as a little bit autistic. You are either autistic or not. It's like that, it's not like, oh, I have a little bit of Down syndrome, I have a little bit of fibromyalgia, I have a little bit of cancer. Like, no, you either have it or you don't have it. You either are or you are not. And when it comes to autism, you either are or you are not. It's not a matter of having it. It's not like a thing that accoplates into you on a receptor and just like, oh, I have this thing. And then we can like try to avoid it with like avoiding vaccines and a bunch of other shit. That's not how autism works whatsoever. Uh, but there are like things that are gonna trigger it and happen make it uh be uh presentable a little bit earlier in your life versus later in your life. The thing is, uh, why delay it? Why avoid it, right? Like I feel things so intensely. If I feel passion, anger, love, interest, uh frustration. I feel everything so intensely, and I love that lens is in life, right? It's not something that I'm trying to like remove or something like that. But when I talk to these people who are like a little bit autistic, they're all try finding ways of like bypassing their autism as opposed to like working with it. And I'm like, that's how you know it's not legitimately autism because you can't escape it. Every single thing that you do is through those lenses. It's kind of like if you're a Christian or if you have a political leaning that's very strong, you can't see life apart from that, right? Like it's just the lenses of like who you are and everything. And I am uh I'm very grateful for being who I am and I wouldn't want it in any other way, regardless of the difficulties that I face every single fucking day. You know, like I was uh talking to uh this guy who was my coach, and he was like, Man, I want your work ethic. I I wish I could just like sit down in front of my computer and do all the work like you do. And I'm like, bro, I am drugged uh a lot. Like uh, as my professor from seminary would say, uh Dr. Fuck, what was his name? No, it's not Dr. Dew. Dr. Dew threw an eraser at me for me being a materialist. Uh, but I was making a claim that the soul is material, not immaterial, and he didn't understand that. But in any case, uh, then he took my scholarship away because I was in a Christian school and I said, this atheist guy is actually correct about the interpretation of this text. And then they took my entire scholarship away. Isn't that nice? Uh, which is why like uh uh the academic environment should be free for you to pursue whatever the fuck you want to pursue. Any theory you have, just fucking prove it. Make it happen, right? And I uh I took that to an extreme. I wanted to prove that my arguments were very, very good, and I wanted to put my arguments on the line to be attacked to see if I'm actually right or not. So in every paper in college that I had the chance, I would argue against like the the thesis, the dissertation, the paper, the book that that professor had wrote. Because if I gotten an A plus arguing against the thing that this guy has argued, it's because my evidence is really fucking solid and my way of reasoning is pretty fucking solid. And uh I graduated Summa Kum Lare, so uh I I I did it. Not because I'm smart, but just because I'm fucking like just uh I just I just need to have shit fit perfectly, right? If I if I look at a paper and I'm like, this looks like a 50 page uh citation paper. Uh it just kind of like I I will not stop until I've considered every single possible angle, which is uh incapacitating at times, but it's also where a lot of this good stuff that you guys are asking me about it comes from. It comes from this type of stuff. But in any case, Enough of ranting about uh autism. You want to say something about your ADHD or something like that?

SPEAKER_01 44:04

I'm good. Let's read the next question.

SPEAKER_00 44:06

Okay, let's read the next question.

SPEAKER_01 44:08

I am planning on placing another peptide order tomorrow. Based on where I am at in the program and my current progress, when do you think you would typically start introducing additional peptides or making changes to the protocol? I am not looking to rush anything because I trust the process, but I'm curious what you were thinking in terms of timeline and what the next phase might look like.

SPEAKER_00 44:28

Okay, I really like this question because it shows like how I work. Uh, I don't have uh people taking a fuck ton of peptides from the beginning in general. I do see some people and then I started with that. It's the it's dependent, right? As some people are gonna say, like, um, you know, when we were in the podcast with uh, I think it was DJ, we were talking about like, hey, get the fundamentals in place and then we start the peptides. Absolutely. The guys that are working with me, they already have the fundamentals in place. So why would I not start peptides out the gate? It depends on their context. It depends if they need it or not. I do think that some supplements are way better than peptides for certain things. And habits as well. Sometimes they outshine peptides by a mile, by a fucking mile. Medications, people forget about medications. People are like, the max, the nupe, BDNF. Nupep doesn't work with BDNF, it's HGF, I think. Uh, but it's like you guys are pushing all of these compounds that have very little research. And I'm like, SSRIs also like work on BDNF. Fluvox, I mean, is great, but you guys want to keep fucking hammering methylene blue so that you can bypass complex one, which is really cool. It does create an alternative route of electron flow. But uh, have you ever thought about, have you ever asked yourself, is there a problem with skipping a step that my body finds to be natural? I'm just I'm not even gonna cover that because I have some stuff coming up with that, but I just wanted to uh throw that into you guys. Okay, so to answer this person's question, I already did answer, and I said, he's like, hey, I'm not looking to rush anything. And I'm like, you did rush it because I sent you a 20-page document explaining the rationale and the direction that we're going with every single thing. So you are rushing because you didn't read it. So uh let's start with actually fucking reading what's there. Uh when in terms of the direction, you also know because it's mapped out for your full year or for six months at least, but we always map out your future inside of Optolab, so you already know where we're going. But in terms of the peptides, like, why would I tell someone like, hey, get these peptides in hand, but don't start using them? I'll let you know when I start using it. Why? It's because I'm looking at their biofeedback and I want to see certain things in place before I move to the next direction. So if I'm trying to work on insulin sensitivity and I added berberine in place and I have metformin, I have zetomide, and I have like just whatever the fuck, fish oil mega dosing, DHA specifically. Uh EPA, sorry, not DHA, DHA is for something else. It actually works against insulin sensitivity if the dose is too high compared to your DHA EPA. But in any case, uh, I want to know if those things are moving in the right direction or not. If I just throw 40 things at once at the same time, I don't know. So I like to stagger things and work on them like specifically, and like I don't like to do everything at the same time. So, like, we're either gonna break down mitochondria or we're gonna rebuild mitochondria or we're gonna build new mitochondria or repurposing parts, or we are going to power the mitochondria, but we're not gonna do all of these things at the same time. So it's very clear like, hey, once we're breaking down mitochondria, you feel like shit. Uh, that's a sign. Uh, once we're building more mitochondria, you feel worse. That is a major sign. We didn't get rid of the senestia cells. Like, so it just gives me uh more flexibility and uh a cleaner data. And cleaner data is always gonna allow me to steer you in the right direction. So I feel like a lot of people they're they're so used to traditional coaching, which just assumes that people are stable and like a spreadsheet, that you can just like receive a program, run it for 18, 20 weeks, and it's always the same. I don't work that way. I every single week there might be a change, uh, or there might be no changes whatsoever for eight months. It depends on you. I'm trying to give you the best results. I'm not trying to give you the most complex protocol or the most simple protocol. I'm just trying to get you the best results. So I think that uh that is a little bit of a breakdown of like how I work with my phases and stuff like that. But like, well, like we were just saying in the beginning of the podcast, like I had the idea of extending the push phase for two weeks, just bouncing that off of you. Why? Because I want your feedback? No, because I I like within your risk profile, based on where you're at, uh, where do you think like about this idea now, right? I have uh I had someone in prep that I was like, uh, what do you think? Do you want to run this compound this way or do you want to run the compound that way? Do you want to take a break this week or do you want to take a break the next week? And like for a lot of people, that does look like, man, you really don't know what you're doing. FY, I I don't give a shit if you guys think that I know what I'm doing or not. Like, if I if I do something, people are like, oh, that's not like a good image, that's not a good presentation, right? Because like uh they're gonna think that you don't know. You're putting the the the the decision and the choice into them, and you need to be the one telling them what they need. And I'm like, I don't work with fucking retarded people. Everyone that I worked with is pretty fucking smart, and I believe in a collaborative environment. You know your body better than I do. You are in closer contact with your body more than I am. So what I'm gonna do is I'm just gonna like my job is to get rid of the noise. What people say it's like, what coaches say is like, oh, I shouldn't, I I'm not gonna ask you for your opinion because I want my own data and I trust my own data. And I'm like, are you so bad at data management that you can't separate noise from signal when someone normal is reporting it to you? Like, you couldn't work as an EMS because you would arrive to the person, like, what happened? I was like, oh no, never mind, I don't need your data. I'm actually gonna figure out what it is because I went to school for this, so I'm super fucking smart and I've been doing this for 10 years. And the guy's like fucking spilling blood everywhere. I just don't find that to be a good working model. So that's why I believe it's more of a collaboration thing, you know? And I I I'm so into this, uh, into this world of collaboration and I love it so much. That when I started working with another coach, like that was the main issue that I faced was like, oh shit, there's no collaboration at all. Ah, fuck, I forgot that this is the standard in the industry. It's you telling me what to do because you assume that I'm fucking stupid. Ah shit, that's not gonna work for me. And at the same time, like when I was working with uh I was uh on a call with someone, she was like, my previous coach didn't change my training for six months, didn't change my diet for six months and everything. And I was like, well, but there are good reasons for this, right? You uh there's there's uh there's this and that reason, right? It could be some uh motor learning, some DHT that's actually coming into place to help with uh faster like recruitment and all these things. Like there's a good reason for this. There's the timeline that we have in the research of like how long it takes you for you to get like proficient with the movement. There's the four layers of proficiency, right? Like there's so many things to consider. And she was like, Yeah, like that's the answer I want to hear. But for my coach, I just heard more is not better. And I'm like, Well, you sound like a prophet. That sounds really, really cool. And it sounds like you give you some aura or shit like that. People don't need aura. Your clients need clarity. Uh, so uh I'm just uh very much outside when people ask me, like, how do other coaches work and stuff like that? I'm like, I know how they work, but in in general, I don't love it. Now there are people out there that I fucking love and I trust and I would love to work with them. Absolutely. I'm not I'm not saying I'm the only one here. I I I don't want you guys to hear that. Please, for the love of God, I am not saying that in any way, shape, or form. I'm just talking about myself in relation to the people that I know and the vast majority of things. So very loosely, loose goose here. You want to add something to that or should we go to Instagram rapid fire questions?

SPEAKER_01 50:39

Let's go to Instagram rapid fire questions. How long do you run BPC 157 before you know if it's actually working?

SPEAKER_00 50:46

Depends what you're running it for. Uh, but I'm assuming that this person asked because of like, oh, my elbow hurts. So how long did it take for you to get better? When you're looking at the research of like how long elbow tendinopathy takes to recover, it's about a year whether you do PT or not. Doing PT actually changes the relapse rate, which is very important, but it doesn't make it recover any faster, so to speak. Tendons recover and ligaments, they recover very, very slow. There's very little blood flow, which is why BPC is so useful for them. Uh, but in general, like four to six weeks, you're noticing a lot of things going on. But if it is for something else, like for instance, for uh when I was leveraging BPC for anhedonia, um, that's like a 12, 14 week uh work there of laying the foundation there with GHK copper. Uh, what about for like fibromyalgia? Like if you have a flare, oh shit, that's a matter of hours. Like I had a my one of my clients that were working on fibromyalgia, like he was even like, I wonder if it's the supplement. Like, no, it is. It's just the other ones are working underneath the hood, so to speak, like long term. This one is working like more acutely and faster. So it just depends on what you're or what you're what you need it for.

SPEAKER_01 51:44

Can you take peptides orally or does it have to be injected to actually do anything?

SPEAKER_00 51:48

Depends on the peptide, right? So KPV uh acts in the gut orally, uh, apparently through a very short half-life. BPC157 is extracted from the gut mucosal ionies. So uh it literally absorb it, it literally works very, very well with that. But then when it comes to like peptides in longer chains, they have to go through this transporter called P P uh PEPT1, uh Pep T1, um, which is basically only gonna carry amino acids that are like less than four amino acids long into the gut, otherwise, they're gonna get destroyed. So it's the transporter that's gonna tag fragments of proteins that you eat. It's also gonna transport your uh your peptides, which is why uh tripeptides and dipeptides like bioregulators, they work very well orally, right? You can take thyreogen, stomach cord, and glendochord, like all of these SM ones orally because they're small enough. So either they need to be modified to be to be bypassing the gut, and or they need to be coming from the gut, or they need to be injected or small enough to actually be absorbed orally, but they need to be modified, yeah.

SPEAKER_01 52:42

What's the difference between taking T3 and T4? And why would someone choose one over the other?

SPEAKER_00 52:47

Uh, you take T4 if your doctor told you so, or if you never thought about this in any way, shape, or form. You take T3 if you're smart, because you're trying the goal is not to fix your lab like your panel. The goal is to give you a good life. So to do that, you're gonna give the metabolism what it needs, where it needs in the tissues. So since the conversion of T4 to T3 is very unreliable, it affects the DIO2 THR92 BLA variant, it affects about 60% of people. MCT8 and MCT10 transporter uh cannot just be like it's not like a rat that you can just bypass that with an OATP1C1 transporter coming in place to transport the T3 into your brain. So you need to have that local production as well. And that is all done by D2. And apart from the pituitary, which has a protective mechanism against the self-tagging and destruction of it, uh, for every single weather tissue, you need the active hormone itself. So you feed the active hormone itself. Nobody is fucking mega dosing zinc and vitamin D and Tonga Ali to raise their testosterone. So they just inject tests. Same logic, just inject this. People are running secretogogs because they're fucking stupid, because they don't know that it down the receptor literally eat it uh it desensitizes in a matter of 30 minutes of you injecting. And this stays, it gets progressively worse, which is crazy because I I hear of like some pretty big names in the industry running multiple secretogogs at the same time for years at a time, uh, which I'm like just not doing anything. So we just take GH. Same logic, we just take T3 directly. Yeah. But if you want to know more about T3, there's only one place on the entire internet where you can give like a fucking 10-hour course on thyroid, uh, because it touches every single part of your body. Like, that's the thing people don't understand. They're like, oh, why would I take such a long course just on the thyroid? Because it sets your fucking stem cell production to recover your muscles, therefore, muscle growth. It also acts on the circa 2A pump for calcium channeling as well as circa two, because it creates GLUT 4 transporters, because it builds serotonin receptors and sets uh serotonin uh receptor sensitivity and density as well. Like, because it sets your rate of bone turnover and it like puts your your your your um your um uh follicles into the growth cycle as opposed to the shed and weight cycle. Like, there's so many reasons, right? Santa Fibrotic for there's so many fucking things. Like, why would you just take T4 and hope for the best when all of the research literally shows that it's bad, uh, that it doesn't really do the work that it's doing? And then some person is gonna put in the comments, I take T4 and it works. And I'm like, yeah, because you are in the 10% of people who respond well to it. You are in the minority. The medical textbook was built on an assumption that after being validated by Bianco has been proven to be false. The problem is that assumption solidified the guidelines for over 10 years ago. And then we had some poorly run trials of head-to-head comparisons between T4 and T3, where we ran the wrong protocol for T3 and we capped the benefit via TSH, which is horrendous. And then it showed that T4 and T3, uh there's no benefit to adding T3. And I'm like, yeah, if you remove the benefit, there's gonna show no benefit. Absolutely. Like if you have people wearing glasses on a study, and every time their vision starts to get a little bit better and they get a headache, you're like, oh, let's remove it because they got a headache. The glasses cause the headache. I was like, no, their eyes are just adapting. What the fuck are you talking about? So it looks like glasses don't solve eye problems, right? That's what happened with the T4 and the T3 studies. But then with Ball and uh and uh uh Bianco's group in uh 2025, 2026, we just see the safety of T3 just being so fucking strong that the entire field is basically like, hey, just some open questions here. Like with T4, over 77% of people were still going to take T4 and experience brain fog and fatigue. 60% of them is a mood issue and cognition. Uh like 50% of them is something related to their uh metabolism, right? I don't remember off the top of my head. But like you have if a if a if a restaurant was putting out meals and three out of four of those meals gave people stomach aches, you would think that's a bad restaurant. Uh that's T4. So uh let's go to the good restaurant.

SPEAKER_01 56:28

Do peptides lose their potency if they have been reconstituted for more than a couple of weeks?

SPEAKER_00 56:33

Yeah, theoretically, yeah. Uh in practice, I just don't see that happening. But again, in practice, like I'm not measuring this shit on a lab, so I just don't know. But I if I'm running something, and the like I ended my 12-week phase with this compound, like Tymus and Alpha 1, and there's a tiny little bit left, I'm gonna run it like two more days. And then just end it. So that I I only use the vial once it's like, you know, full and ready. And then for like, you want to let them, the, the, the, the water actually sort of marinate with the peptides and and and become like activated for all of those little crystals. So you don't like reconstitute and inject right away. Waiting 24 hours is a really good idea, especially if you have like one of those uh I forgot the name, but they basically like keep the formulation active. It's like this lab thing that just keeps it rotating the entire time. That would be like the perfect thing, and you're only injecting everything within 28 days. I see a lot of people getting good results with that. It's just that I find that for the majority of people, it's so cumbersome, it's so expensive that it's not worth it. Like, even myself, like I would I like to run all that shit. I'm like, yeah, I would, but like how much is it really making a difference? I don't know. I feel like I could just push for one more rep at the gym and go to sleep 20 minutes earlier, and I would get more benefits out of that than uh buying a $500 thing to rotate my shit, you know? So yeah.

SPEAKER_01 57:42

If someone's thyroid labs look normal but they feel like garbage, is it worth supplementing T3?

SPEAKER_00 57:47

Uh granted that T3 is the actual problem, then yes, the thing is like there could be something else. The way that the reason that I like to start with T3 is that because it has its hands on pretty much every dial in your body, once you solve all of the problems with T3, then you know what is truly a cognition problem, what is truly a metabolic problem, what is truly like a an insulin issue or something like that, or a sleep problem, or sleep apnea, right? Because like your sleep apnea could be coming from the gel-like substance, uh substance that is literally formed, which was a like a tell sign of uh myocedema, that is actually going to thicken your vocal cord, so your voice gets steeper in T3, uh, well, when you when you have a low T3, and also your your tongue gets wider. So it you can literally develop sleep apnea from hypothyroidism. So, like, would you just like throw a cognitive enhancer in there, like some uh racetams, and then for your mood, just an SSRI, and then for the sleep apnea, some fucking uh a CPAP uh machine, and then for your insulin, some MOTSI and actual insulin, like you're taking all of these things. You could just take T3, and then if you still have the problem afterwards, then you know that it was not thyroid related, but you start with the thyroid because it is the master dial. Now to the question of like my labs look normal, but I still feel like garbage, normal doesn't mean shit. I've hammered this on so like so often that I'm honestly getting tired of saying this, but normal just means this is a snapshot of a crowd if it's 95% of people in general, and these people include sick people that have not been diagnosed, aka the majority of people, because doctors only have 10 minutes to give you and they don't they're not paying attention to your shit. So, like the TSH range literally comes down to 13,000 people and it sets the range for the entire world. But then your different labs, like Quest and Lab Corp, they don't really agree on the change. As a matter of fact, the whole the biggest debate in thyroidology is whether to treat or not treat subclinical hypothyroidism, which is measured by the TSH. So the TSH band itself since the 1970s, we literally don't know where people should stand at. We know that if you drop under point uh point one, you're you raise your risk fractures like in your spine, like over 3.5 times, hip fractures like something like four times or something like that, if you are old. But like it's just a lot of like empty spaces that we don't know in terms of the reference range. So, like, I when I'm building someone, dude, we're going by every possible uh uh direction uh dashboard. We're using every dashboard that we can. I'm gonna use your temperature, your pulse, your appetite, your energy levels, your mood, your sexual libido. I'm gonna use your actual blood work as well. I'm gonna use everything that I know about reference ranges and times and all the contests and everything to nail down your dose. But I don't, I don't I have I'm never suggesting people to just like take T3 whenever they feel like shit. Never suggested that. Also, not saying that every problem is caused by T3, also not saying that every solution comes from T3. I'm saying it's the best thing that you can put in the beginning because the risk is extremely low, extremely safe, and you get the most bang for your butt because it's touching most things at the same time. So just like with testosterone TRT, we're trying to solve multiple issues at once. Well, T3 actually solves a lot of those issues, including fertility, which is why a TSH test is pretty much mandatory whenever you're winning uh your for your fertility to figure out what it is, because motility and mobility are morphology, sorry, are both going to be impacted whether you have too much thyroid or too little thyroid. So finding that balance is very important, but you have your own balance because of set point theory. Set point theory, not related to body weight, but when it comes to the thyroid, that is established. People have a very narrow band of where they feel best. And my job is to find a narrow band and put you there, not to just tell you, oh, in general, people feel well like this. Good fucking luck finding your sweet spot. Like, that doesn't work, which is why I'm like, it sounds like I'm pretty vague about this stuff. I'm like, no, I'm giving you all the specifics. It's just you're gonna have to do a lot of the homework. Like counting all of the papers that I read on the thyroid, we just crossed 1,300 papers last week. Like, good luck. Like, go ahead with like doing all of that, or we can just sit down and talk about it to try to like find that in uh in a matter of a couple of hours, as opposed to you spending the next three years trying to solve an issue that wasn't there to be solved in the first place. Like, there's so many instances in which adding thyroid is going to make things worse. Uh, there are literally some instances in which it looks like you're hypothyroidism. And if you add thyroid uh medication to this person, you're going to speed up how fast they get to their fucking grave. So you need to understand the kind. I'm not just suggesting that you take it. And also, my protocol is not just T3. Like, T3 solves the problem of like not having active hormone. It still has to be transported into the cell, it still has to be hovered inside of the cell, inside of the cell, it still has to be activated. And once it's activated, all the receptors still have to listen to it. So there's five failure points after the T3. We're just breaking a bunch of other failure points that come with everybody, which is conversion. But to for the T3 to actually land, that's the rest of the protocol. That's the mitochondria, that's the thyroid, that's the cellular stuff. And this is the stuff that I break down inside of my course for you for you guys to know. But it's like, I'm not suggesting just take T3 and your life is gonna be better. No, you need an entire fucking system. And the reason you don't get results is because you're still looking at compounds, thinking in terms of like, hey, what uh what compound is gonna give me X points uh for my you're looking like a video game, my mana, my health, my XP, and all this type of shit. And I'm like, that's not how it works. Uh, you need a you need a system, not a pile of drugs.

SPEAKER_01 1:02:47

How do you decide when to add a new peptide versus increasing the dose of the one you're already on?

SPEAKER_00 1:02:52

Holy shit, how is this a rapid fire question? Uh, it depends, man. It depends. So let's say my case, I'm not, let's say my insulin sensitivity was not getting better. I would probably raise the dose of the compounds that I have first before adding new compounds. Why? Because I want to know if it's a threshold type of thing. So, like you do see in a lot of like compound uh blends and stuff like that. It's like, oh, it has some like thyroid stuff. It has a little bit of selenium and iodine and zinc and iron and and all these sorts of things, right? And I'm like, well, that's fantastic. But like the dose is so low that it's not doing anything. Also, these three things are literally uh competing for the same activator or transporter or cofactor, so they're not going to be activated or transformed to the active form for your body to use. So it's just shit uh from the bottom all the way to the top. So I try to, I prefer to raise the doses while it's reasonable to do so. And if it's not working, I usually have already figured out like why it's not working. And if I figured out, like, oh, it's probably because of like this third pathway that's not being activated because there's this missing piece, I'm gonna try to add the missing piece and then it usually unlocks. Sometimes it's like, no, you were looking from a different angle. Uh, there was actually like a there was a post in front of you, and you were trying to guess where the next thing is. If we just move you in this direction, because now we have these sets and this many weeks of data, then we're able to able to see that it's like, oh no, we should tackle this from a completely different angle. So it depends on the person uh very, very much.

SPEAKER_01 1:04:09

Is there a point where stacking too many peptides becomes counterproductive?

SPEAKER_00 1:04:14

What do you think?

SPEAKER_01 1:04:16

Yes. Why because they can all be fighting against each other in some cases?

SPEAKER_00 1:04:24

Absolutely. Yeah, they can fight against each other, right? Like look at the uh the example of the BAM 15 and SLU. I don't give a shit what smart people are talking about. I I I just I just care about how SLU and BAM 15 work. One is making the mitochondria less efficient on purpose, the other one is making the mitochondria extremely efficient on purpose. You put both of them together and you're like telling the mitochondria to be super efficient, and at the same time you're telling the mitochondria to just not be efficient. I'm like, what do you think that happens? I think Anthony Castor broke down the negatives that can happen because it can literally sprite down into like, you know, you're gonna notice some brain fog, you're gonna notice some lack of energy and stuff in the beginning, but then later down the road, what you're actually going to notice is it might actually like you might develop some issues that could be like permissive on the environment for something like the big C-word, which we can't say on YouTube. Uh, but I already did like four times this episode, so just put it together. I'm not talking about the the the the the the thing that took over the world a while ago. I'm talking about the thing that everybody's mostly scared of. So you guys, you see a lump and you're scared of that, you already know what I'm talking about. So uh yes, there are points and it's gonna become counterproductive uh counterproductive. Also, I just think about SLU building more engines and making it like rev them up, right? Pushing them. Uh you also put in some T3, which also pushes the mitochondria to run hotter. You also put some uh some uh compounds that are going to be like uh uh yohimbean, right? And it's also going to push your system onto norepinephrine, which is literally going to feed the genomic arm uh, well, the non genomic arm, I'm sorry, of uh T3, which is gonna feed into a faster mitochondria. So, like just think if you don't have the capacity to deal with that oxidative stress, okay, but then you add oxidative stress, you you deal with the glutathione, you take vitamin C, vitamin E, like you add all these things. It's like, okay, now you fuck up. Redox balance. It's too unbalanced. You have too many firefighters, you don't have enough of a fire. Like you just created a problem on the other end, right? So it just I find that uh having too many things in place generally just makes things very complicated. I don't, I'm not a fan of having very intricate protocols uh because of this primarily. It just creates so much crosstalk, and when it comes to like pharmac uh uh uh a polypharmacy, we just don't know what a lot of this diversity is doing to us, you know? So yeah, I think it's absolutely uh it's absolutely in there.

SPEAKER_01 1:06:28

You guys, with your questions, my goodness, what does a typical peptide rotation look like over a full year? For who?

SPEAKER_00 1:06:36

What's your goal?

SPEAKER_01 1:06:37

What's your goal? I have nothing uh yeah, what who are you? What's your goal? What issues are you dealing with? How much money do you have um to spend on this stuff? Yeah. So many different factors.

SPEAKER_00 1:06:48

No, she nailed it. It's if you want to look at an example of like what it looks like for me to build a generalized protocol for like a uh a bodybuilder or someone who's enhanced or in the optimization space and stuff like that, you go to the engine and then you go to the bioregulators course, and then you go to the one that literally is uh how to build a full year rotation matching peptides, bioregulators, and supplements. So there's a lecture there for this particular go watch the lecture, you go learn that stuff, and then you ask me more questions if you have questions, and uh, I will answer them inside of the engine for you guys.

SPEAKER_01 1:07:15

Can thyroid medication mask an underlying issue that should be fixed instead?

SPEAKER_00 1:07:21

Yes, yes, it can. Uh fuck me. That's uh such a huge question. I'm not I'm not gonna develop more into this, but like I said before, into the T3, you could be solving a problem that's not the actual problem. So, like when it comes to like T3, it sits upstream of the majority of things, right, uh in your body. The thing is, like, there are things that sit upstream of T3, for instance, your adrenals. So you could be solving a T3 problem, but in reality, you do have an adrenal issue. Maybe your storage of DHA is not there, right? So like it depends on what I'm looking into, like your blood work and stuff like that, but it can absolutely mask a problem that's really there. So that is why like proper diagnosis is so damn important. And why I take so long to like nail down someone's first plan is because I want to nail it down from the beginning. I don't want to have to change direction and just be like, oh yeah, I fucked up. I didn't consider this thing. Like, no, we're gonna nail this shit from the beginning, regardless of how long it takes.

SPEAKER_01 1:08:09

How do you know if your gut issues are affecting your thyroid conversion? And what do you do about it?

SPEAKER_00 1:08:14

Okay, so first of all, the gut doesn't really uh it doesn't really convert, right? Because it doesn't have D2 deigenase. This is something that I got very wrong uh because I was taught this from other people. But it only has a D1 deigenase. Well, the gut doesn't have diodenasis at all, as a matter of fact. Uh the liver and the and is going to have a D1 deodenase, the kidneys as well. So it's gonna be mostly focused on filtration and recycling. So you could theoretically, well, not theoretically, you will be uh pretty much like pissing away a lot of the active C3 that has been converted instead of like using it because of gut integrity. But the primary issue for the gut is that when your zonulin is elevated, those tight junctions are gonna open and they're gonna re- uh things that were supposed to stay outside of your blood are going to be in your blood, like LPSS, and those things are gonna raise a lot of inflammation, which inflammation is what's going to be the one of the triggers, uh, which if it paired with like a lifestyle trigger, like trauma, a difficult year, some someone dying or something like that, or it's just stressful work or lack of sleep, like so many things, or gluten, like there's so many things that's going to trigger your like Hashimoto's or your Graves' disease or something like that, uh, or Hashi toxicosis or or more. So, how do you know if it's affecting your thyroid conversion? Uh, one, it doesn't do conversion. So there's there's that piece in there. Don't get mistaken. Uh, the whole thing comes from a misinterpretation of a of a thesis study that was published in a paper, uh, in a book actually in 2010. So it wasn't even an academic paper. Literally, functional health people uh in general, the more that I learn about this group, uh, the more that I see this like, oh, you guys are just like uh just the holistic crowd. You guys don't have like you you are act you have access to more peptides and supplements and stuff, but you are still not using the academic rigor that medicine actually taught us to like actually think through these things instead of being so open-minded that your brain just falls off. So, what do you do about it? Uh, well, if you have an issue with your tie junctions, close your tie junctions. If you have an issue with stomach acid inhibiting the absorption of your compounds and vitamins, which is going to trigger like B12, pernicious anemia and things like that, uh, then you solve those things as well by not putting iron first, but actually solving the issues like I've been teaching on Instagram. And then uh at the same time, you're also retraining your immune system and you're also supporting uh your thyroid directly as well as cellular entry and utilization of these compounds. So that's pretty much how you would uh how you would do that. But if you want more details on how exactly to do that, the thyroid course is where to go. Speaking of course, I gotta get back to work. Guys, thank you so much for popping on another episode of our fantastic QA made just for you guys, so that you guys can learn a little bit of how I deal with uh clientele and uh how I'm actually like processing these things for people in real life as we go. More videos coming up tomorrow, videos yesterday, videos tomorrow, videos on Friday, fucking banger interview. Super excited for this interview coming up on Friday, guys. Keep leaving comments, keep sending me messages, keep posting, keep tagging, keep doing everything because that's how we grow. And when we grow, you guys get more shit. You guys get more shit, you're more optimized, you're more optimized, you're more happy. So just like the video, subscribe, drop a comment, and I'll talk to you guys soon. Peace the fuck out. Peace.