Spontaneous reports of adverse drug reactions are a common source of evidence in pharmacovigilance, but as the science evolves, so do the types of data used to find and assess signals. Uppsala Monitoring Centre’s Daniele Sartori reviews how signal detection practices have changed over time.
Tune in to find out:
Want to know more?
Check out the full scoping review that inspired this episode.
In 2002, Meyboom and colleagues discussed criteria to select and follow up on signals.
In the first chapter of Uncertainty in Pharmacology, Aronson explains the difference between evidence for a mechanism and evidence from a mechanism.
In 2018, Murad and colleagues published a method to evaluate the quality of evidence in a series of case reports.
UMC scientists have shown how chemical information can support timely signal detection.
In partnership with the EHDEN consortium, UMC researchers are exploring whether observational health data can assist signal prioritisation and validation – more on that in the next episode!
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