Inside the Cure with Dr. Charles Mok

FDA Updated Guidance on Estrogen Therapy: What Women Should Know

Allure Medical

The FDA has updated its stance on estrogen therapy, reversing decades of confusion from early WHI interpretations. New research and global data now show estrogen may support long-term health and reduce key chronic risks.

This episode explains the FDA’s updated guidance, what the WHI got wrong, and what current science reveals about heart health, brain function, diabetes risk, bone density, and breast cancer. We also break down synthetic progestins vs. bioidentical progesterone, why timing matters, and how Europe achieved better outcomes with HRT.

Tune in to get clear, evidence-based insights so you can talk confidently with your provider and decide if hormone therapy fits your goals.

Timestamps:
 00:00 FDA Update
 00:27 WHI Misinterpretation
 01:05 Synthetic vs Bioidentical
 02:14 Why Estrogen Was Blamed
 03:12 Black Box Warning
 04:48 New Research
 06:10 Heart/Brain/Cancer Data
 07:45 Europe’s Approach
 08:30 Progestins vs Progesterone
 09:45 What It Means Today
 10:45 Why Doctors Stopped HRT
 11:30 FDA 2025 Review
 12:28 Black Box Removal
 13:25 Key Takeaways
 14:05 How to Discuss HRT

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