{"version":"1.0.0","segments":[{"speaker":"Barrie Tan","startTime":0.75,"endTime":6.99,"body":"I'm always fascinated to know what are the things that can help our body to be in a better"},{"speaker":"Barrie Tan","startTime":6.99,"endTime":13.11,"body":"state? Assuming that as we grow older, our balance is off and I need to bring it back to"},{"speaker":"Barrie Tan","startTime":13.11,"endTime":15.72,"body":"balance. And this vitamin E is."},{"speaker":"Peter Bowes","startTime":18.24,"endTime":22.47,"body":"Dr. Barrie Tan is the leading expert on vitamin E."},{"speaker":"Peter Bowes","startTime":22.56,"endTime":25.78,"body":"He is the president of American River Nutrition."},{"speaker":"Peter Bowes","startTime":25.8,"endTime":30.78,"body":"He says his mission is simple to improve the everyday health of people."},{"speaker":"Peter Bowes","startTime":32.55,"endTime":36.71,"body":"Hello again and welcome to the Live Long and Master Aging podcast."},{"speaker":"Peter Bowes","startTime":36.72,"endTime":42.57,"body":"I'm Peter Bowes. This is where we explore the science and stories behind human longevity."},{"speaker":"SPONSOR MESSAGE","startTime":42.6,"endTime":47.43,"body":"This episode is brought to you in association with Clinique La Prairie, the award winning"},{"speaker":"SPONSOR MESSAGE","startTime":47.43,"endTime":52.47,"body":"spa clinic and pioneering health and wellness destination nestled on the shores of Lake"},{"speaker":"SPONSOR MESSAGE","startTime":52.47,"endTime":54.48,"body":"Geneva in Montreux, Switzerland."},{"speaker":"SPONSOR MESSAGE","startTime":54.63,"endTime":60.42,"body":"Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La"},{"speaker":"SPONSOR MESSAGE","startTime":60.42,"endTime":65.58,"body":"Prairie offers a holistic approach to living fuller, healthier and longer lives."},{"speaker":"Peter Bowes","startTime":66.48,"endTime":71.61,"body":"In this episode, we're going to discuss the role of Vitamin E plays in human longevity and"},{"speaker":"Peter Bowes","startTime":71.61,"endTime":75.84,"body":"how much attention we should pay to it in our daily lives."},{"speaker":"Peter Bowes","startTime":75.87,"endTime":79.87,"body":"Dr. Tan, welcome to the Live Long and Master Aging podcast."},{"speaker":"Barrie Tan","startTime":79.89,"endTime":81.77,"body":"Thank you. Thank you for inviting me."},{"speaker":"Barrie Tan","startTime":81.78,"endTime":83.19,"body":"Looking forward to this."},{"speaker":"Peter Bowes","startTime":83.22,"endTime":84.86,"body":"Great pleasure to talk to you."},{"speaker":"Peter Bowes","startTime":84.87,"endTime":87.35,"body":"Let's go straight to the heart of the matter."},{"speaker":"Peter Bowes","startTime":87.36,"endTime":89.64,"body":"What is the vitamin E?"},{"speaker":"Barrie Tan","startTime":89.7,"endTime":97.62,"body":"The vitamin E was discovered exactly 100 years ago, 1922, by two medical doctors at UC"},{"speaker":"Barrie Tan","startTime":97.62,"endTime":103.92,"body":"Berkeley. And they discovered this alpha-tocopherol at the time because it's able to help"},{"speaker":"Barrie Tan","startTime":103.92,"endTime":105.51,"body":"the fetus to full term."},{"speaker":"Barrie Tan","startTime":105.51,"endTime":110.67,"body":"Most people don't really know that, but it helps the fetus to go to full term."},{"speaker":"Barrie Tan","startTime":110.67,"endTime":117.57,"body":"But most people know after its discovery of the fetal to full term, it is a powerful"},{"speaker":"Barrie Tan","startTime":117.57,"endTime":122.49,"body":"antioxidant. So today most people know them, know it as an antioxidant."},{"speaker":"Barrie Tan","startTime":122.76,"endTime":125.88,"body":"My role in vitamin E is not in a discovery."},{"speaker":"Barrie Tan","startTime":125.88,"endTime":128.88,"body":"I simply is not old enough for 100 years in it."},{"speaker":"Barrie Tan","startTime":129.03,"endTime":137.4,"body":"But 40 years after the discovery of Tocopherol, a very similar compound to the original"},{"speaker":"Barrie Tan","startTime":137.4,"endTime":141.54,"body":"vitamin E, not tocopherol is called tocotrienol."},{"speaker":"Barrie Tan","startTime":141.57,"endTime":148.41,"body":"It was discovered by two groups separately, one at the USDA in the Midwest, and the other"},{"speaker":"Barrie Tan","startTime":148.41,"endTime":150.46,"body":"one in University of Liverpool."},{"speaker":"Barrie Tan","startTime":150.48,"endTime":156.9,"body":"They extracted this from rubber and then they found out this compound very similar to"},{"speaker":"Barrie Tan","startTime":156.9,"endTime":159.27,"body":"Tocopherol and called tocotrienol."},{"speaker":"Barrie Tan","startTime":159.3,"endTime":165.15,"body":"That probably was in the mid sixties and I started my career 20 years after that in the"},{"speaker":"Barrie Tan","startTime":165.15,"endTime":166.41,"body":"mid eighties."},{"speaker":"Barrie Tan","startTime":166.41,"endTime":172.7,"body":"And then I started to study this tocotrienol, and have stayed ever since in the 40 years."},{"speaker":"Peter Bowes","startTime":172.71,"endTime":176.09,"body":"Just tell me a little bit about your career that you refer to there."},{"speaker":"Peter Bowes","startTime":176.1,"endTime":179.55,"body":"You studied chemistry and biochemistry in New Zealand."},{"speaker":"Barrie Tan","startTime":179.55,"endTime":180.69,"body":"Yes, yes."},{"speaker":"Barrie Tan","startTime":180.69,"endTime":186.84,"body":"I went to my original home is Malaysia and New Zealand and Australia aren't too far away."},{"speaker":"Barrie Tan","startTime":186.84,"endTime":191.52,"body":"So I went to school in University of Otago in Dunedin on the Southern Island, was there"},{"speaker":"Barrie Tan","startTime":191.52,"endTime":196.5,"body":"for the entire eight and one half nine years to get my bachelors and PhD degree in"},{"speaker":"Barrie Tan","startTime":196.5,"endTime":198.21,"body":"chemistry and biochemistry."},{"speaker":"Barrie Tan","startTime":198.21,"endTime":204.96,"body":"Then then a short trip over to Auburn University, Alabama, where I did postdoc, did"},{"speaker":"Barrie Tan","startTime":204.96,"endTime":210.24,"body":"cancer study, and then soon after that I started my career as an assistant professor at"},{"speaker":"Barrie Tan","startTime":210.24,"endTime":213.18,"body":"the University of Massachusetts in Amherst, Mass."},{"speaker":"Barrie Tan","startTime":213.18,"endTime":218.85,"body":"And I've never left the area, even though after ten, 11, 12 years, I left the university."},{"speaker":"Barrie Tan","startTime":218.85,"endTime":226.56,"body":"So in the last 30 years, I've been focusing on discovery, almost like a medicine man and"},{"speaker":"Barrie Tan","startTime":226.56,"endTime":230.16,"body":"not and yet not to look for compounds in nature."},{"speaker":"Barrie Tan","startTime":230.16,"endTime":236.25,"body":"If I discover it, then I must figure out a way how to extract them to study further and"},{"speaker":"Barrie Tan","startTime":236.25,"endTime":242.19,"body":"if it further yields fruitful result and how to materialize the usefulness of this"},{"speaker":"Barrie Tan","startTime":242.19,"endTime":245.29,"body":"natural extract for the human soul."},{"speaker":"Peter Bowes","startTime":245.4,"endTime":249.03,"body":"So we're going to do a dive into Vitamin E."},{"speaker":"Peter Bowes","startTime":249.39,"endTime":252.75,"body":"I mentioned American River Nutrition in my introduction."},{"speaker":"Peter Bowes","startTime":252.75,"endTime":255.48,"body":"Just tell me a little bit more about it."},{"speaker":"Peter Bowes","startTime":255.48,"endTime":256.83,"body":"You started with your wife."},{"speaker":"Barrie Tan","startTime":256.83,"endTime":260.57,"body":"Yes, we my wife, Elizabeth and I started this."},{"speaker":"Barrie Tan","startTime":260.57,"endTime":267.24,"body":"When we started the company, I was very fascinated to focus on lipid soluble vitamin, the"},{"speaker":"Barrie Tan","startTime":267.24,"endTime":275.67,"body":"lipid soluble vitamins, vitamin A, D, K and E, and these kind of compound B and C are"},{"speaker":"Barrie Tan","startTime":275.67,"endTime":281.28,"body":"exceptions, they're water soluble, and they are found quite abundantly in nature if you"},{"speaker":"Barrie Tan","startTime":281.28,"endTime":282.39,"body":"know how to get it."},{"speaker":"Barrie Tan","startTime":282.6,"endTime":289.71,"body":"And it was an accidental find for me, Peter, where I was in South America probably about"},{"speaker":"Barrie Tan","startTime":290.64,"endTime":293.76,"body":"25 years ago, looking for something else."},{"speaker":"Barrie Tan","startTime":293.76,"endTime":300.67,"body":"It was. And then I saw this plant, beautiful annatto plant discovered about 500 years ago"},{"speaker":"Barrie Tan","startTime":300.67,"endTime":309.16,"body":"during the Spanish inquest into South America and then about 100 years, hundred and 50"},{"speaker":"Barrie Tan","startTime":309.16,"endTime":313.47,"body":"years later, the British also stumble into it and they call it the lipstick plant."},{"speaker":"Barrie Tan","startTime":313.48,"endTime":319.99,"body":"So if you go to a botanical garden to look for annatto plant sometime referred to as the"},{"speaker":"Barrie Tan","startTime":319.99,"endTime":327.36,"body":"lipstick plant or the Spanish call it achiote, and the Portuguese word is urucum."},{"speaker":"Barrie Tan","startTime":327.37,"endTime":330.46,"body":"So either one of those would will take you to it."},{"speaker":"Barrie Tan","startTime":330.79,"endTime":338.23,"body":"In the West, however, the popular use of it is to color cheese, the yellowish orange hue."},{"speaker":"Barrie Tan","startTime":338.26,"endTime":340.74,"body":"Doritos chips, macaroni and cheese."},{"speaker":"Barrie Tan","startTime":340.75,"endTime":343.06,"body":"Those kinds of things are from annatto color."},{"speaker":"Barrie Tan","startTime":343.18,"endTime":349.92,"body":"So my role in this is the color mask, the beauty of the nutrient inside."},{"speaker":"Barrie Tan","startTime":349.93,"endTime":355.87,"body":"So I was fascinated with this plant because somehow the colors stay good for a long time."},{"speaker":"Barrie Tan","startTime":355.87,"endTime":360.4,"body":"So I surmise that something potent is protecting the color."},{"speaker":"Barrie Tan","startTime":360.4,"endTime":366.37,"body":"So I removed the color mixed in which is used in every facet in the West."},{"speaker":"Barrie Tan","startTime":366.4,"endTime":369.25,"body":"Then I notice that there's a powerful antioxidant."},{"speaker":"Barrie Tan","startTime":369.25,"endTime":372.98,"body":"At the time I was expecting this to be a polyphenol."},{"speaker":"Barrie Tan","startTime":373.0,"endTime":378.7,"body":"Many people talked, talked about that, but then I found out 'Oh, it is not a polyphenol'"},{"speaker":"Barrie Tan","startTime":378.73,"endTime":385.69,"body":"then more surprisingly it is a vitamin E, and most surprisingly it is a vitamin E that is"},{"speaker":"Barrie Tan","startTime":385.69,"endTime":388.54,"body":"devoid of tocopherol, which is a common one."},{"speaker":"Barrie Tan","startTime":388.54,"endTime":392.44,"body":"Instead, it is the rarer one, tocotrienol."},{"speaker":"Barrie Tan","startTime":392.44,"endTime":395.08,"body":"Now the chance finding out this."},{"speaker":"Barrie Tan","startTime":395.08,"endTime":402.46,"body":"I already have been studying tocotrienol now for 20 years before that, so I immediately"},{"speaker":"Barrie Tan","startTime":402.46,"endTime":409.24,"body":"embark on study on all chronic conditions of tocotrienol and the the reason I went with"},{"speaker":"Barrie Tan","startTime":409.24,"endTime":411.04,"body":"this with gusto was."},{"speaker":"Barrie Tan","startTime":411.93,"endTime":418.56,"body":"At the time I already knew the common Tocopherol Vitamin E doesn't do any good."},{"speaker":"Barrie Tan","startTime":418.68,"endTime":421.11,"body":"Only only as an antioxidant."},{"speaker":"Barrie Tan","startTime":421.11,"endTime":427.23,"body":"And most of the function is on tocotrienol, but in nature is very hard to find"},{"speaker":"Barrie Tan","startTime":427.62,"endTime":434.19,"body":"tocotrienol. And when I did my whole life, career, was arrested, and in the last 25 years"},{"speaker":"Barrie Tan","startTime":434.19,"endTime":439.8,"body":"I just about did nothing else but to study this and then study many, many animals study"},{"speaker":"Barrie Tan","startTime":439.8,"endTime":446.94,"body":"and having about nearly two dozen clinical trials on on anything on chronic conditions,"},{"speaker":"Barrie Tan","startTime":446.94,"endTime":454.11,"body":"prediabetes, diabetes, fatty, liver disease, obesity, osteopenia and cancer."},{"speaker":"Barrie Tan","startTime":454.11,"endTime":458.64,"body":"I know there's a lot. The reason I saw it out there, time may not permit you to ask, but"},{"speaker":"Barrie Tan","startTime":458.91,"endTime":463.56,"body":"if you can pick and choose anyone then now describe that particular one for you."},{"speaker":"Peter Bowes","startTime":463.56,"endTime":470.64,"body":"Well, let's go back to maybe some basics and look at vitamin E, And this is a podcast"},{"speaker":"Peter Bowes","startTime":470.64,"endTime":472.92,"body":"focused on human longevity."},{"speaker":"Peter Bowes","startTime":472.92,"endTime":474.93,"body":"It is focused on aging."},{"speaker":"Peter Bowes","startTime":474.93,"endTime":481.71,"body":"So in terms of the essential components of vitamin E, as we grow older, what are the"},{"speaker":"Peter Bowes","startTime":481.71,"endTime":482.72,"body":"benefits?"},{"speaker":"Barrie Tan","startTime":482.73,"endTime":490.23,"body":"The main benefit, if you say somebody is not ill or sick like that would be if you think"},{"speaker":"Barrie Tan","startTime":490.23,"endTime":496.71,"body":"of the human body, we have 38 trillion cells and think of the cell like a bean shape."},{"speaker":"Barrie Tan","startTime":496.83,"endTime":499.65,"body":"And this is as basic as you can get it."},{"speaker":"Barrie Tan","startTime":499.65,"endTime":504.27,"body":"And on longevity and in the cell, there's a cell wall."},{"speaker":"Barrie Tan","startTime":504.27,"endTime":510.51,"body":"You got to have a cell wall to contain all the constituent of the cell, like the nucleus"},{"speaker":"Barrie Tan","startTime":510.51,"endTime":515.85,"body":"that that that make you look like you and me look like me or like the mitochondria that"},{"speaker":"Barrie Tan","startTime":515.85,"endTime":518.67,"body":"produce energy, that's all inside the cell."},{"speaker":"Barrie Tan","startTime":518.67,"endTime":522.45,"body":"So in a sense, this is a gated community."},{"speaker":"Barrie Tan","startTime":522.48,"endTime":525.39,"body":"Only the nutrient goes in and the waste goes out."},{"speaker":"Barrie Tan","startTime":525.39,"endTime":533.49,"body":"But if the cell wall is compromised, then aging properly as we know it will be"},{"speaker":"Barrie Tan","startTime":533.49,"endTime":536.79,"body":"compromised in the most rudimentary sense."},{"speaker":"Barrie Tan","startTime":536.82,"endTime":539.61,"body":"38 trillion is a big number."},{"speaker":"Barrie Tan","startTime":539.64,"endTime":544.46,"body":"It approximate to about 5000 times the population of the earth."},{"speaker":"Barrie Tan","startTime":544.47,"endTime":553.62,"body":"So if you think of a human body containing 120 to £180, it had this 38 trillion cell and"},{"speaker":"Barrie Tan","startTime":553.62,"endTime":555.66,"body":"the cell walls need to be protected."},{"speaker":"Barrie Tan","startTime":555.66,"endTime":558.24,"body":"Now, this is, this is where the rub is."},{"speaker":"Barrie Tan","startTime":558.96,"endTime":566.88,"body":"More than half of the cell wall is fat and the fat is the lowest line food to get to go"},{"speaker":"Barrie Tan","startTime":566.88,"endTime":574.35,"body":"bad. Think of a think of a you're driving past a road kill on a summer day or you put a"},{"speaker":"Barrie Tan","startTime":574.35,"endTime":579.54,"body":"stick of butter out of anything and you return to to smell it 2 hours later."},{"speaker":"Barrie Tan","startTime":579.54,"endTime":582.99,"body":"That off smell is fat going off."},{"speaker":"Barrie Tan","startTime":582.99,"endTime":585.39,"body":"Yes, protein can go off."},{"speaker":"Barrie Tan","startTime":585.39,"endTime":586.95,"body":"Yes. Carbohydrate."},{"speaker":"Barrie Tan","startTime":586.95,"endTime":589.89,"body":"Even your DNA, nucleic acid can go up."},{"speaker":"Barrie Tan","startTime":589.89,"endTime":593.64,"body":"None go off as fast as fat."},{"speaker":"Barrie Tan","startTime":593.64,"endTime":599.97,"body":"So therefore, in my judgment, since more than half of the fat is in the parts of our"},{"speaker":"Barrie Tan","startTime":599.97,"endTime":605.43,"body":"body, we cannot see if you hold your love handle, that's only part of the fat you can"},{"speaker":"Barrie Tan","startTime":605.43,"endTime":613.62,"body":"see. And therefore and in those parts, the vitamin E is the most common substance that"},{"speaker":"Barrie Tan","startTime":613.62,"endTime":616.05,"body":"protect the fat from going back."},{"speaker":"Barrie Tan","startTime":616.05,"endTime":617.61,"body":"And they reside."},{"speaker":"Barrie Tan","startTime":617.61,"endTime":621.72,"body":"They are situated their domicile right in the cell wall."},{"speaker":"Barrie Tan","startTime":621.75,"endTime":624.72,"body":"Most people don't bother to tell you that, Peter."},{"speaker":"Barrie Tan","startTime":624.72,"endTime":631.35,"body":"Once we once we understood that, that is the rudimentary understanding of longevity."},{"speaker":"Barrie Tan","startTime":631.35,"endTime":632.58,"body":"As I understand it."},{"speaker":"Peter Bowes","startTime":632.58,"endTime":639.36,"body":"My understanding of vitamin E has always been that it was one of those vitamins that, yes,"},{"speaker":"Peter Bowes","startTime":639.36,"endTime":645.27,"body":"we get from our diet and probably one of the lesser likely ones that we need to"},{"speaker":"Peter Bowes","startTime":645.27,"endTime":651.54,"body":"supplement with if we are eating a balanced diet that we probably don't need to worry"},{"speaker":"Peter Bowes","startTime":651.54,"endTime":653.73,"body":"about it. Is that fair enough?"},{"speaker":"Peter Bowes","startTime":653.73,"endTime":654.3,"body":"As an observation."},{"speaker":"Barrie Tan","startTime":654.3,"endTime":662.58,"body":"That is fair enough as an observation as to our understanding of to the RDA, the"},{"speaker":"Barrie Tan","startTime":662.58,"endTime":669.75,"body":"recommended daily allowance that the US Government provide, and they say that 100% RDA"},{"speaker":"Barrie Tan","startTime":669.78,"endTime":673.5,"body":"would be about 10 to 15 milligrams."},{"speaker":"Barrie Tan","startTime":673.86,"endTime":677.85,"body":"If you say by that rule then 10 to 15 milligrams."},{"speaker":"Barrie Tan","startTime":677.85,"endTime":681.84,"body":"True. You can get it from mostly vegetable oil and fat."},{"speaker":"Barrie Tan","startTime":681.84,"endTime":685.95,"body":"That's where the plant makes them, They put them in the fat tissues and for obvious"},{"speaker":"Barrie Tan","startTime":685.95,"endTime":689.96,"body":"reasons, plant never makes anything for human being."},{"speaker":"Barrie Tan","startTime":689.97,"endTime":692.7,"body":"It's only in our head that we think that they make it for us."},{"speaker":"Barrie Tan","startTime":692.73,"endTime":694.92,"body":"They make it to protect itself."},{"speaker":"Barrie Tan","startTime":694.92,"endTime":700.44,"body":"And is isn't it interesting when the plant makes vitamin E, they put it in the fat to"},{"speaker":"Barrie Tan","startTime":700.44,"endTime":702.45,"body":"protect the fat from oxidation."},{"speaker":"Barrie Tan","startTime":702.45,"endTime":708.09,"body":"That's so. Therefore, if you eat a lot of vegetable oil and fat and we try to reduce that"},{"speaker":"Barrie Tan","startTime":708.09,"endTime":712.97,"body":"for management of our health, then you get in the Vitamin E."},{"speaker":"Barrie Tan","startTime":712.97,"endTime":719.51,"body":"We have found that in the modern day stress at a huge component to our life and with that"},{"speaker":"Barrie Tan","startTime":719.51,"endTime":726.2,"body":"stress and huge component to our life and we are handling overweight, obesity, fatty"},{"speaker":"Barrie Tan","startTime":726.2,"endTime":731.57,"body":"liver and all these chronic conditions, the amount of vitamin E that we need, it had to"},{"speaker":"Barrie Tan","startTime":731.57,"endTime":738.59,"body":"be increased unless one would be a squeaky clean person with no ill know anything, then"},{"speaker":"Barrie Tan","startTime":738.59,"endTime":742.32,"body":"perhaps the minimum amount of 15 milligrams would suffice."},{"speaker":"Barrie Tan","startTime":742.34,"endTime":748.31,"body":"So I kind of answer your question and kind of still questioning that in the modern day"},{"speaker":"Barrie Tan","startTime":748.31,"endTime":750.07,"body":"life that isn't going to be true."},{"speaker":"Barrie Tan","startTime":750.11,"endTime":753.35,"body":"You and I, neither you and I are born in this country."},{"speaker":"Barrie Tan","startTime":753.35,"endTime":758.06,"body":"We live in this country significantly long enough, and the US government is repeatedly"},{"speaker":"Barrie Tan","startTime":758.06,"endTime":766.4,"body":"telling us that about 30% of Americans are overweight and another 25% are obese."},{"speaker":"Barrie Tan","startTime":766.4,"endTime":770.12,"body":"But then that is already off the kilter of normal."},{"speaker":"Peter Bowes","startTime":770.51,"endTime":773.57,"body":"It's interesting your observation about stress."},{"speaker":"Peter Bowes","startTime":773.57,"endTime":779.12,"body":"I'm curious in terms of what is happening within our bodies when we're experiencing that"},{"speaker":"Peter Bowes","startTime":779.12,"endTime":785.6,"body":"stress and how it affects our nutritional needs and especially as it applies to vitamin"},{"speaker":"Peter Bowes","startTime":785.6,"endTime":792.23,"body":"E, because as you correctly observe, it is a modern day epidemic, almost,the stress that"},{"speaker":"Peter Bowes","startTime":792.23,"endTime":795.8,"body":"people feel, and especially now we've gone through a pandemic."},{"speaker":"Peter Bowes","startTime":795.8,"endTime":801.98,"body":"The world is suffering all sorts of grave issues that are putting a lot of stress on"},{"speaker":"Peter Bowes","startTime":801.98,"endTime":807.17,"body":"people. A lot of people are just simply suffering from hunger around the world."},{"speaker":"Peter Bowes","startTime":807.17,"endTime":811.91,"body":"And we're talking about the Western world, that these problems are really stressing"},{"speaker":"Peter Bowes","startTime":811.91,"endTime":817.28,"body":"people out. And from what you say, that's creating issues that people are not aware of,"},{"speaker":"Peter Bowes","startTime":817.46,"endTime":823.4,"body":"how it affects our intake and our needs from food and people wouldn't necessarily make"},{"speaker":"Peter Bowes","startTime":823.4,"endTime":828.14,"body":"the connection, would they, between vitamin E and the stress that they are feeling?"},{"speaker":"Barrie Tan","startTime":828.14,"endTime":833.03,"body":"Yes. Let me answer this in the way that I know how to answer, Peter."},{"speaker":"Barrie Tan","startTime":833.07,"endTime":838.46,"body":"And in fact, I'm just reading a piece of work that was just sent to us using"},{"speaker":"Barrie Tan","startTime":838.49,"endTime":844.64,"body":"tocotrienol and they study people who are pre-diabetic and we already have study done on"},{"speaker":"Barrie Tan","startTime":844.76,"endTime":850.16,"body":"metabolic syndrome, which means that people their metabolites in the body is all out of"},{"speaker":"Barrie Tan","startTime":850.16,"endTime":855.14,"body":"kilter, sugar, triglyceride, cholesterol, all we we need all this to live, but they're"},{"speaker":"Barrie Tan","startTime":855.14,"endTime":858.46,"body":"out of kilter and we also studied people with fatty liver."},{"speaker":"Barrie Tan","startTime":858.47,"endTime":864.86,"body":"And what came back is this we always try to measure oxidized fat."},{"speaker":"Barrie Tan","startTime":865.28,"endTime":871.73,"body":"And when we did in the blood, we found that for those who are not taking any vitamin E,"},{"speaker":"Barrie Tan","startTime":871.76,"endTime":875.75,"body":"they oxidized fat, not fat, oxidized fat is high."},{"speaker":"Barrie Tan","startTime":875.99,"endTime":881.71,"body":"And then when we gave them the vitamin E, the oxidized fat is typically reduced 20 to"},{"speaker":"Barrie Tan","startTime":881.71,"endTime":883.79,"body":"25%. So that's tell tales."},{"speaker":"Barrie Tan","startTime":883.79,"endTime":884.81,"body":"It is a marker."},{"speaker":"Barrie Tan","startTime":884.84,"endTime":887.27,"body":"It doesn't tell the precise disease."},{"speaker":"Barrie Tan","startTime":887.27,"endTime":892.43,"body":"The marker tells us that the oxidized fat is in control or reduced."},{"speaker":"Barrie Tan","startTime":892.46,"endTime":893.9,"body":"So that's one sign."},{"speaker":"Barrie Tan","startTime":894.2,"endTime":897.83,"body":"Another sign that we try to measure is inflammation."},{"speaker":"Barrie Tan","startTime":897.83,"endTime":900.26,"body":"It's another way to measure stress."},{"speaker":"Barrie Tan","startTime":900.26,"endTime":902.33,"body":"And there is a marker in the body."},{"speaker":"Barrie Tan","startTime":902.39,"endTime":904.46,"body":"It's called C-reactive protein."},{"speaker":"Barrie Tan","startTime":904.46,"endTime":906.59,"body":"You can ask your doctor to measure them."},{"speaker":"Barrie Tan","startTime":906.59,"endTime":913.13,"body":"And the C-reactive protein under stress and duress, the liver spew out this protein and"},{"speaker":"Barrie Tan","startTime":913.13,"endTime":914.81,"body":"you can measure them in the blood."},{"speaker":"Barrie Tan","startTime":914.81,"endTime":921.71,"body":"And when we gave them vitamin E tocotrienol , the C-reactive protein also dropped"},{"speaker":"Barrie Tan","startTime":921.95,"endTime":927.97,"body":"approximately 20 to 30%, depending on the condition to be studied."},{"speaker":"Barrie Tan","startTime":927.98,"endTime":935.81,"body":"So those two markers tells me that the oxidative stress is reduced because we see that"},{"speaker":"Barrie Tan","startTime":935.81,"endTime":940.6,"body":"the fat getting oxidized is reduced and the inflammation is also reduced."},{"speaker":"Barrie Tan","startTime":940.61,"endTime":947.3,"body":"And then this last one, we did not count for this in the design of the study when we were"},{"speaker":"Barrie Tan","startTime":947.3,"endTime":949.61,"body":"measuring people with fatty liver disease."},{"speaker":"Barrie Tan","startTime":949.61,"endTime":951.62,"body":"Clearly fatty liver disease is."},{"speaker":"Barrie Tan","startTime":951.62,"endTime":958.01,"body":"And in other words, we we are consuming foods that are too much carbohydrate and too much"},{"speaker":"Barrie Tan","startTime":958.04,"endTime":965.99,"body":"fat such that our liver look like somebody who have gone to alcohol abuse cirrhosis."},{"speaker":"Barrie Tan","startTime":966.02,"endTime":968.54,"body":"Now, that statement is just massive."},{"speaker":"Barrie Tan","startTime":968.57,"endTime":976.31,"body":"It was only discovered by Mayo Clinic in 1980s and is simply long arcade with non"},{"speaker":"Barrie Tan","startTime":976.31,"endTime":978.59,"body":"alcohol, fatty liver disease."},{"speaker":"Barrie Tan","startTime":978.59,"endTime":983.48,"body":"And it's so named because the liver looked like somebody with liver cirrhosis."},{"speaker":"Barrie Tan","startTime":983.48,"endTime":990.62,"body":"So we decided to take it on to study it and it massively reduce steatosis, which is fat"},{"speaker":"Barrie Tan","startTime":990.62,"endTime":992.6,"body":"in the liver and fibrosis."},{"speaker":"Barrie Tan","startTime":992.6,"endTime":997.13,"body":"If the fat is not controlled, they will have scarring tissue fibrosis."},{"speaker":"Barrie Tan","startTime":997.13,"endTime":998.65,"body":"And we saw that reverse."},{"speaker":"Barrie Tan","startTime":998.66,"endTime":1004.87,"body":"All this is to say, because I know you you are asking the question, if I don't have all"},{"speaker":"Barrie Tan","startTime":1004.87,"endTime":1008.74,"body":"this concern, how do I reduce the stress in my life?"},{"speaker":"Barrie Tan","startTime":1008.74,"endTime":1015.55,"body":"And I would say the measurement of oxidized fat and the measurement of inflammation."},{"speaker":"Barrie Tan","startTime":1015.55,"endTime":1022.93,"body":"We saw a clear distinction it would reduce, but this amount needed above that of the 100%"},{"speaker":"Barrie Tan","startTime":1022.93,"endTime":1025.18,"body":"RDA that the government sets."},{"speaker":"Peter Bowes","startTime":1025.81,"endTime":1028.57,"body":"This is the Live Long and Master Live Long and Master Aging podcast."},{"speaker":"Peter Bowes","startTime":1028.57,"endTime":1034.84,"body":"Our guest is Dr. Barrie Tan, a long time and respected researcher into Vitamin E."},{"speaker":"Peter Bowes","startTime":1034.87,"endTime":1039.79,"body":"So we've talked about the relationship between vitamin E and perhaps the everyday"},{"speaker":"Peter Bowes","startTime":1039.79,"endTime":1042.25,"body":"stresses that people might be feeling."},{"speaker":"Peter Bowes","startTime":1042.25,"endTime":1045.97,"body":"I think the question that most people will have is, well, how do I know?"},{"speaker":"Peter Bowes","startTime":1045.97,"endTime":1053.35,"body":"How do I know that I need to perhaps pursue some vitamin E supplementation to add to what"},{"speaker":"Peter Bowes","startTime":1053.35,"endTime":1055.3,"body":"I'm getting through my diet?"},{"speaker":"Peter Bowes","startTime":1055.3,"endTime":1056.83,"body":"What is the test?"},{"speaker":"Peter Bowes","startTime":1056.83,"endTime":1057.91,"body":"What should people do?"},{"speaker":"Barrie Tan","startTime":1057.94,"endTime":1063.55,"body":"The best test would be to learn it from a bloodwork that the doctor would provide."},{"speaker":"Barrie Tan","startTime":1063.55,"endTime":1070.33,"body":"Measuring inflammation, measuring the metabolites like sugar, triglyceride and"},{"speaker":"Barrie Tan","startTime":1070.33,"endTime":1072.94,"body":"cholesterol. They call it a lipid panel."},{"speaker":"Barrie Tan","startTime":1073.24,"endTime":1078.01,"body":"If one does not want to do blood work, it's a little bit of a crapshoot."},{"speaker":"Barrie Tan","startTime":1078.01,"endTime":1084.37,"body":"But you can still do if you look into your skin only because the skin is the only organ"},{"speaker":"Barrie Tan","startTime":1084.37,"endTime":1085.75,"body":"outside our body."},{"speaker":"Barrie Tan","startTime":1085.75,"endTime":1093.64,"body":"And if it looks scratchy, patchy and not very vascular, that would be a telltale sign of"},{"speaker":"Barrie Tan","startTime":1094.27,"endTime":1098.17,"body":"what's inside is not going to be good."},{"speaker":"Barrie Tan","startTime":1098.23,"endTime":1102.07,"body":"That that would be the only measurement that I know of."},{"speaker":"Barrie Tan","startTime":1102.07,"endTime":1105.4,"body":"The way we learn this also indirectly."},{"speaker":"Barrie Tan","startTime":1105.43,"endTime":1109.0,"body":"I'll give you two examples in two of our clinical study."},{"speaker":"Barrie Tan","startTime":1109.0,"endTime":1111.94,"body":"One were in breast cancer patients."},{"speaker":"Barrie Tan","startTime":1112.21,"endTime":1116.07,"body":"They were taking tocotrienol vitamin E for breast cancer."},{"speaker":"Barrie Tan","startTime":1116.08,"endTime":1122.89,"body":"Now the context and when they start taking it clearly a work to mitigate chronic"},{"speaker":"Barrie Tan","startTime":1122.89,"endTime":1124.96,"body":"condition like breast a very severe."},{"speaker":"Barrie Tan","startTime":1125.7,"endTime":1132.9,"body":"But they were reporting that with radiation and their skin, they noticed that their skin"},{"speaker":"Barrie Tan","startTime":1132.9,"endTime":1134.13,"body":"got better."},{"speaker":"Barrie Tan","startTime":1134.37,"endTime":1135.87,"body":"So that is a telltale."},{"speaker":"Barrie Tan","startTime":1135.9,"endTime":1137.91,"body":"Even though there was not the intent."},{"speaker":"Barrie Tan","startTime":1137.94,"endTime":1143.7,"body":"The other one was people with severe inflammation, meaning lupus."},{"speaker":"Barrie Tan","startTime":1143.7,"endTime":1147.78,"body":"They cannot move their hand or rheumatoid arthritis."},{"speaker":"Barrie Tan","startTime":1147.87,"endTime":1151.77,"body":"People who have this will know immediately know what I meant."},{"speaker":"Barrie Tan","startTime":1151.89,"endTime":1158.64,"body":"When they start taking these vitamin E, they notice that the severe inflammation is"},{"speaker":"Barrie Tan","startTime":1158.64,"endTime":1162.63,"body":"reduced on conditions like lupus and rheumatoid arthritis."},{"speaker":"Barrie Tan","startTime":1162.66,"endTime":1168.42,"body":"All that to say that if you do not need to do bloodwork to measure C-reactive protein,"},{"speaker":"Barrie Tan","startTime":1168.42,"endTime":1171.85,"body":"you will find no if you have severe condition, this would help."},{"speaker":"Barrie Tan","startTime":1171.87,"endTime":1179.22,"body":"So I knew, in fact I was guided by some of these comments that people tell me to know how"},{"speaker":"Barrie Tan","startTime":1179.22,"endTime":1180.81,"body":"to conduct clinical trials."},{"speaker":"Barrie Tan","startTime":1180.81,"endTime":1184.47,"body":"So it's not like magically I do everything scientific."},{"speaker":"Barrie Tan","startTime":1184.47,"endTime":1189.57,"body":"Not always. Sometimes I do, but sometimes people tell me things and I say, Oh, let me"},{"speaker":"Barrie Tan","startTime":1189.57,"endTime":1191.88,"body":"figure out a way how to design a study."},{"speaker":"Barrie Tan","startTime":1191.88,"endTime":1196.02,"body":"And then I go back to scientific based on things people tell me."},{"speaker":"Barrie Tan","startTime":1196.02,"endTime":1200.43,"body":"So those would be the two indication, if you will, not to do a blood work."},{"speaker":"Peter Bowes","startTime":1200.43,"endTime":1202.65,"body":"And from what you've said already."},{"speaker":"Peter Bowes","startTime":1203.1,"endTime":1206.37,"body":"Vitamin E supplements don't all come equal."},{"speaker":"Peter Bowes","startTime":1206.37,"endTime":1212.27,"body":"If you were to go to a store, there's often a vast array that you can choose from."},{"speaker":"Peter Bowes","startTime":1212.28,"endTime":1215.78,"body":"Where do people start in determining what is best for them?"},{"speaker":"Barrie Tan","startTime":1215.79,"endTime":1218.77,"body":"Okay, that is an excellent question."},{"speaker":"Barrie Tan","startTime":1218.79,"endTime":1226.11,"body":"If you go to a store to buy vitamin E, unlike some other vitamins, 90% of the vitamin"},{"speaker":"Barrie Tan","startTime":1226.11,"endTime":1229.23,"body":"would be TOCOPHEROL, which means that you don't want it."},{"speaker":"Barrie Tan","startTime":1229.44,"endTime":1233.13,"body":"You have enough tocopherol from your food."},{"speaker":"Barrie Tan","startTime":1233.16,"endTime":1239.58,"body":"So you want to look for the word tocotrienol and 10%, which means one in every ten bottle"},{"speaker":"Barrie Tan","startTime":1239.58,"endTime":1240.84,"body":"of vitamin E would be that."},{"speaker":"Barrie Tan","startTime":1240.84,"endTime":1243.39,"body":"And then further, you want to distinguish it."},{"speaker":"Barrie Tan","startTime":1243.39,"endTime":1246.0,"body":"There's only three sources of tocotrienol."},{"speaker":"Barrie Tan","startTime":1246.0,"endTime":1251.19,"body":"In all three I have discovered over my 30 years career like that."},{"speaker":"Barrie Tan","startTime":1251.28,"endTime":1255.48,"body":"What, from Rice, from Palm and from Annatto?"},{"speaker":"Barrie Tan","startTime":1255.51,"endTime":1262.41,"body":"From Rice and from Palm about 25 to 50% of the vitamin E is TOCOPHEROL."},{"speaker":"Barrie Tan","startTime":1262.44,"endTime":1265.08,"body":"So they're good, but they're not good enough."},{"speaker":"Barrie Tan","startTime":1265.26,"endTime":1272.16,"body":"And then in Annatto is the only source in my entire life of studying these that it is"},{"speaker":"Barrie Tan","startTime":1272.16,"endTime":1273.51,"body":"free of tocopherol."},{"speaker":"Barrie Tan","startTime":1273.51,"endTime":1276.97,"body":"It contains vitamin E only tocotrienol."},{"speaker":"Barrie Tan","startTime":1277.02,"endTime":1284.37,"body":"Hence, in the last 25 years we have committed to do 20 over clinical trials on"},{"speaker":"Barrie Tan","startTime":1284.37,"endTime":1291.36,"body":"tocotrienol so I don't have to waste time on including tocopherol when tocopherol does"},{"speaker":"Barrie Tan","startTime":1291.36,"endTime":1298.77,"body":"not work. So therefore when you go to the store to look for or go on the internet to buy"},{"speaker":"Barrie Tan","startTime":1298.77,"endTime":1307.02,"body":"vitamin E by Annatto tocotrienol, Annatto Vitamin E and Annatto is a ANNATTO."},{"speaker":"Barrie Tan","startTime":1307.05,"endTime":1308.63,"body":"It's just a name of the plant."},{"speaker":"Barrie Tan","startTime":1308.64,"endTime":1314.46,"body":"And if you see that word, that means that would be the kind of vitamin E you would need."},{"speaker":"Barrie Tan","startTime":1314.46,"endTime":1320.7,"body":"Or if you simply go on the internet to Google Annatto tocotrienol and what research you"},{"speaker":"Barrie Tan","startTime":1320.7,"endTime":1326.58,"body":"will quickly figure out the vitamin E that work from the clinical study that have been"},{"speaker":"Barrie Tan","startTime":1326.58,"endTime":1327.48,"body":"produced."},{"speaker":"Peter Bowes","startTime":1327.48,"endTime":1333.3,"body":"And I would always advise people, look, if you're considering changing an aspect of your"},{"speaker":"Peter Bowes","startTime":1333.3,"endTime":1337.26,"body":"nutrition, the first person you should speak to is your professional health advisor,"},{"speaker":"Peter Bowes","startTime":1337.56,"endTime":1342.42,"body":"speak to your doctor, and you've referred to getting blood tests through your doctor."},{"speaker":"Peter Bowes","startTime":1342.57,"endTime":1345.15,"body":"I'm sure you would echo that kind of advice."},{"speaker":"Barrie Tan","startTime":1345.15,"endTime":1346.95,"body":"Yes, and I would too."},{"speaker":"Barrie Tan","startTime":1346.95,"endTime":1353.52,"body":"And and if your doctor is not familiar about this annatto vitamin E, and then you can"},{"speaker":"Barrie Tan","startTime":1353.52,"endTime":1356.07,"body":"reach out to me, I will be glad to send you."},{"speaker":"Barrie Tan","startTime":1356.25,"endTime":1357.78,"body":"If you come to a website."},{"speaker":"Barrie Tan","startTime":1357.78,"endTime":1361.92,"body":"We write shorthand white papers and position papers."},{"speaker":"Barrie Tan","startTime":1361.92,"endTime":1366.81,"body":"But if people want to be more granular on it, you say, Well, Dr."},{"speaker":"Barrie Tan","startTime":1366.81,"endTime":1370.5,"body":"Tan, can you send me papers that you suggest would do this?"},{"speaker":"Barrie Tan","startTime":1370.53,"endTime":1372.57,"body":"We'll be glad to do that."},{"speaker":"Barrie Tan","startTime":1372.66,"endTime":1377.97,"body":"But we usually summarize them and then we gave the paper where we found so not all the"},{"speaker":"Barrie Tan","startTime":1377.97,"endTime":1382.26,"body":"studies we do ourselves, some of them, we funded this like we do ourselves."},{"speaker":"Barrie Tan","startTime":1382.26,"endTime":1389.52,"body":"So probably about 60, 70% are not controlled by me, which are actually welcome because"},{"speaker":"Barrie Tan","startTime":1389.52,"endTime":1395.37,"body":"then it won't be construed as somehow I would influence the direction of this study."},{"speaker":"Barrie Tan","startTime":1395.37,"endTime":1401.67,"body":"You know, the study usually have an outcome that I have no say in is done by Professor A,"},{"speaker":"Barrie Tan","startTime":1401.7,"endTime":1404.88,"body":"B, and C in university, X, Y, and Z."},{"speaker":"Barrie Tan","startTime":1404.88,"endTime":1407.52,"body":"You know, so so we funded this study."},{"speaker":"Barrie Tan","startTime":1407.52,"endTime":1414.12,"body":"Otherwise we have no say in the study, which is really what I want, because if it doesn't"},{"speaker":"Barrie Tan","startTime":1414.12,"endTime":1419.85,"body":"work, then then really you turn out to be a snake oil so there wouldn't be any use to"},{"speaker":"Barrie Tan","startTime":1419.85,"endTime":1420.57,"body":"anybody."},{"speaker":"Peter Bowes","startTime":1420.63,"endTime":1424.53,"body":"It's interesting you should use that phrase because it is the thing that I think a lot of"},{"speaker":"Peter Bowes","startTime":1424.53,"endTime":1430.5,"body":"people fear when they consider supplementation - that the snake oil, the advice that they"},{"speaker":"Peter Bowes","startTime":1430.5,"endTime":1432.51,"body":"can't necessarily trust."},{"speaker":"Peter Bowes","startTime":1432.51,"endTime":1434.22,"body":"It might be all over the Internet."},{"speaker":"Peter Bowes","startTime":1434.22,"endTime":1439.11,"body":"And on this podcast, we've talked many times about the fact that it is one of the most"},{"speaker":"Peter Bowes","startTime":1439.11,"endTime":1441.81,"body":"confusing areas of of health care."},{"speaker":"Peter Bowes","startTime":1441.81,"endTime":1447.69,"body":"Supplementation. What is best for me, what do I need to take and whose advice can I trust?"},{"speaker":"Barrie Tan","startTime":1448.23,"endTime":1455.31,"body":"I, about 30 years ago, because I was committed to this area, which is why, you know, I'm"},{"speaker":"Barrie Tan","startTime":1455.31,"endTime":1456.99,"body":"able to bring food on the table."},{"speaker":"Barrie Tan","startTime":1456.99,"endTime":1460.86,"body":"All of us need to do something to bring material food on the table."},{"speaker":"Barrie Tan","startTime":1460.86,"endTime":1468.18,"body":"We did. And and over all these years, I have not failed to put in financial resources."},{"speaker":"Barrie Tan","startTime":1468.18,"endTime":1469.8,"body":"We are a small company."},{"speaker":"Barrie Tan","startTime":1469.8,"endTime":1472.53,"body":"We are the only company discovering this."},{"speaker":"Barrie Tan","startTime":1472.53,"endTime":1475.92,"body":"So it's a it's a long haul in the same direction."},{"speaker":"Barrie Tan","startTime":1475.92,"endTime":1482.04,"body":"And we have 20 over clinical study, which I'm really proud to say that, you know, large"},{"speaker":"Barrie Tan","startTime":1482.04,"endTime":1486.9,"body":"company would merely have two or three studies and they have huge resources and we have"},{"speaker":"Barrie Tan","startTime":1486.9,"endTime":1488.76,"body":"20 over clinical study."},{"speaker":"Barrie Tan","startTime":1488.76,"endTime":1495.3,"body":"And I didn't say this at the beginning, this Annatto plant, the seed, if you touch it, it"},{"speaker":"Barrie Tan","startTime":1495.3,"endTime":1499.88,"body":"stains you. And that's why it's nickname as a lipstick plant."},{"speaker":"Barrie Tan","startTime":1499.88,"endTime":1504.99,"body":"Carotene in life is normally protected in this."},{"speaker":"Barrie Tan","startTime":1505.08,"endTime":1512.52,"body":"For example, if you cut carrot, the beta carotene, you can't reach it unless you put it"},{"speaker":"Barrie Tan","startTime":1512.52,"endTime":1515.49,"body":"on a pan and then you raise the temperature."},{"speaker":"Barrie Tan","startTime":1515.49,"endTime":1518.82,"body":"You can you see the oil becoming yellowish orange color."},{"speaker":"Barrie Tan","startTime":1518.85,"endTime":1526.83,"body":"Or if you slice tomato and you make Italian sauce, you cannot easily access the lycopene"},{"speaker":"Barrie Tan","startTime":1526.83,"endTime":1530.52,"body":"because they're inside the cytoplasm, the cell of the plant."},{"speaker":"Barrie Tan","startTime":1530.61,"endTime":1534.96,"body":"That is how this unstable carotenes is protected."},{"speaker":"Barrie Tan","startTime":1535.47,"endTime":1540.9,"body":"And then if you eat lobster or crustacean, if you ever come to New England, the yucky"},{"speaker":"Barrie Tan","startTime":1540.9,"endTime":1546.57,"body":"green blue color, the moment you cook them, they deproteinate the protein detach from"},{"speaker":"Barrie Tan","startTime":1546.57,"endTime":1549.14,"body":"them, and then they have the wonderful red color."},{"speaker":"Barrie Tan","startTime":1549.15,"endTime":1552.84,"body":"I use this as an explanation every time without fail."},{"speaker":"Barrie Tan","startTime":1552.87,"endTime":1558.27,"body":"However, with the Annatto plant, if you touch it, it actually stains your hand."},{"speaker":"Barrie Tan","startTime":1558.27,"endTime":1564.87,"body":"So all this to say that it is not protected or bound to something."},{"speaker":"Barrie Tan","startTime":1564.87,"endTime":1572.61,"body":"That was when I theorize there's got to be a physical, super powerful antioxidant that"},{"speaker":"Barrie Tan","startTime":1572.61,"endTime":1573.78,"body":"protect the plant."},{"speaker":"Barrie Tan","startTime":1573.81,"endTime":1578.94,"body":"I was just lucky to ask the right question most of the time when I ask this kind of"},{"speaker":"Barrie Tan","startTime":1578.94,"endTime":1582.99,"body":"question, Peter, they are like they enter a cul de sac is a dead end."},{"speaker":"Barrie Tan","startTime":1583.02,"endTime":1584.61,"body":"I can't get anything out of it."},{"speaker":"Barrie Tan","startTime":1584.61,"endTime":1587.31,"body":"But this turned out to be not a dead end."},{"speaker":"Barrie Tan","startTime":1587.31,"endTime":1589.17,"body":"And I remember it so clearly."},{"speaker":"Barrie Tan","startTime":1589.17,"endTime":1592.53,"body":"The year was 1998, 99, like that."},{"speaker":"Barrie Tan","startTime":1592.53,"endTime":1594.81,"body":"So when I did they are 50."},{"speaker":"Barrie Tan","startTime":1595.23,"endTime":1597.57,"body":"I'm trying to touch on something spiritual."},{"speaker":"Barrie Tan","startTime":1597.6,"endTime":1604.62,"body":"There are 50 million chemical on Earth and most of the people who went to Amazonia to"},{"speaker":"Barrie Tan","startTime":1604.62,"endTime":1609.51,"body":"look for this that another thing like a medicine man, they are probably beaten to death"},{"speaker":"Barrie Tan","startTime":1609.51,"endTime":1613.5,"body":"by a snake or killed by a pathogen born mosquito like that."},{"speaker":"Barrie Tan","startTime":1613.5,"endTime":1616.5,"body":"I'm not even a medicine man."},{"speaker":"Barrie Tan","startTime":1616.5,"endTime":1621.57,"body":"I can't speak a word of Spanish and a lot of things being my Chinese background to go to"},{"speaker":"Barrie Tan","startTime":1621.57,"endTime":1622.98,"body":"China and Southeast Asia."},{"speaker":"Barrie Tan","startTime":1622.98,"endTime":1624.57,"body":"There was not where I went."},{"speaker":"Barrie Tan","startTime":1624.6,"endTime":1630.15,"body":"I went to South America looking for something else, not this stumble on this."},{"speaker":"Barrie Tan","startTime":1630.15,"endTime":1635.43,"body":"And then I theorize that they got to be a very powerful antioxidant and it's known for"},{"speaker":"Barrie Tan","startTime":1635.43,"endTime":1636.72,"body":"500 years."},{"speaker":"Barrie Tan","startTime":1636.72,"endTime":1644.22,"body":"And why do I have to privilege to find this thing out and discover this vitamin E?"},{"speaker":"Barrie Tan","startTime":1644.25,"endTime":1650.82,"body":"Because of that intuitive find and spiritual find, I've committed my life to study."},{"speaker":"Barrie Tan","startTime":1650.82,"endTime":1657.36,"body":"If this is something God gives to me, then I need to figure out how this can be useful."},{"speaker":"Barrie Tan","startTime":1657.36,"endTime":1664.83,"body":"So now to shorten it all, in the 25 years I've done this, we probably work with a dozen"},{"speaker":"Barrie Tan","startTime":1664.83,"endTime":1673.56,"body":"universities, many endless number of animal study then culminate it to 20 to 25 clinical"},{"speaker":"Barrie Tan","startTime":1673.56,"endTime":1679.68,"body":"study. I am now very confident and and even some of them I cannot even afford."},{"speaker":"Barrie Tan","startTime":1679.71,"endTime":1686.22,"body":"Do you know we have 7 to 8 clinical study done in the Kingdom of Denmark."},{"speaker":"Barrie Tan","startTime":1686.25,"endTime":1688.71,"body":"They are fantastically well off."},{"speaker":"Barrie Tan","startTime":1688.74,"endTime":1695.55,"body":"They decided to go after four cancers and the four cancers that they study are ovarian,"},{"speaker":"Barrie Tan","startTime":1695.55,"endTime":1698.73,"body":"breast, lung and colon cancer."},{"speaker":"Barrie Tan","startTime":1698.88,"endTime":1700.95,"body":"We have to provide the medicine."},{"speaker":"Barrie Tan","startTime":1700.98,"endTime":1703.97,"body":"They have to do the clinical study out of the account."},{"speaker":"Barrie Tan","startTime":1703.98,"endTime":1707.58,"body":"It probably costs about $15 Million like that."},{"speaker":"Barrie Tan","startTime":1707.58,"endTime":1710.49,"body":"So for this kind of study, take a long time."},{"speaker":"Barrie Tan","startTime":1710.49,"endTime":1716.19,"body":"So far the breast cancer did not prove come out positive."},{"speaker":"Barrie Tan","startTime":1716.19,"endTime":1721.56,"body":"So they're going to repeat the breast cancer study, but the ovarian cancer came out"},{"speaker":"Barrie Tan","startTime":1721.56,"endTime":1726.76,"body":"positive and is able to extend the life of people with ovarian cancer."},{"speaker":"Barrie Tan","startTime":1726.77,"endTime":1730.06,"body":"So I will return back to the audience listening."},{"speaker":"Barrie Tan","startTime":1730.07,"endTime":1731.71,"body":"What is there not to like?"},{"speaker":"Barrie Tan","startTime":1731.72,"endTime":1736.42,"body":"You know, when the study like that, when only medicine can barely do this."},{"speaker":"Barrie Tan","startTime":1736.43,"endTime":1738.68,"body":"These are stage four cancer patient."},{"speaker":"Barrie Tan","startTime":1738.68,"endTime":1743.03,"body":"They do not have any options left and are able to extend their life."},{"speaker":"Barrie Tan","startTime":1743.03,"endTime":1746.45,"body":"So for me and my wife doing this, this."},{"speaker":"Barrie Tan","startTime":1746.8,"endTime":1750.85,"body":"This is this is a gift, you know, and there are 50 million."},{"speaker":"Barrie Tan","startTime":1750.86,"endTime":1753.87,"body":"I happen to stumble a one or two out of fifty."},{"speaker":"Barrie Tan","startTime":1753.89,"endTime":1755.72,"body":"That's a crapshoot for sure."},{"speaker":"Barrie Tan","startTime":1755.75,"endTime":1760.97,"body":"It's a lottery. So so that's why we're very committed to the extent for the X number of"},{"speaker":"Barrie Tan","startTime":1760.97,"endTime":1767.33,"body":"years I still in a career doing this, I will continue to bring to get the maximum number"},{"speaker":"Barrie Tan","startTime":1767.33,"endTime":1773.06,"body":"of clinical study so that the audience would be able to see what this may or may not be"},{"speaker":"Barrie Tan","startTime":1773.06,"endTime":1774.17,"body":"useful to them."},{"speaker":"Peter Bowes","startTime":1774.2,"endTime":1778.82,"body":"So you've personalized your research in a beautiful way."},{"speaker":"Peter Bowes","startTime":1778.82,"endTime":1784.43,"body":"You've talked about the spiritual connection to what you do, which I think leads me to"},{"speaker":"Peter Bowes","startTime":1784.43,"endTime":1789.83,"body":"this question, and I often ask this of people as you look at your own life and you think"},{"speaker":"Peter Bowes","startTime":1789.83,"endTime":1797.3,"body":"about your own human longevity, the years ahead for yourself, do you have aspirations?"},{"speaker":"Peter Bowes","startTime":1797.3,"endTime":1798.56,"body":"Do you have a goal?"},{"speaker":"Peter Bowes","startTime":1798.56,"endTime":1803.6,"body":"And is there anything that you do in your life that is particularly focused on your"},{"speaker":"Peter Bowes","startTime":1803.6,"endTime":1805.7,"body":"longevity and the years ahead?"},{"speaker":"Barrie Tan","startTime":1805.7,"endTime":1812.87,"body":"On the non material side, I would say this to be calm and collected and it's easy for me"},{"speaker":"Barrie Tan","startTime":1812.87,"endTime":1819.11,"body":"to say, and oftentimes I may not be calm, but to be calm and collected, then I will be"},{"speaker":"Barrie Tan","startTime":1819.11,"endTime":1822.44,"body":"able to think about my future better."},{"speaker":"Peter Bowes","startTime":1822.44,"endTime":1824.0,"body":"To keep the stress levels low."},{"speaker":"Barrie Tan","startTime":1824.03,"endTime":1825.98,"body":"You keep the stress level low, probably."},{"speaker":"Barrie Tan","startTime":1825.98,"endTime":1827.3,"body":"That's a very simplistic way."},{"speaker":"Barrie Tan","startTime":1827.45,"endTime":1828.77,"body":"Yes, that's correct."},{"speaker":"Barrie Tan","startTime":1829.04,"endTime":1835.85,"body":"And on the material side, because I'm a chemist, I'm always fascinated to know what are"},{"speaker":"Barrie Tan","startTime":1835.85,"endTime":1841.91,"body":"the things that can help our body to be in a better state, assuming that as we grow"},{"speaker":"Barrie Tan","startTime":1841.91,"endTime":1846.86,"body":"older, our balance is off and I need to bring it back to balance."},{"speaker":"Barrie Tan","startTime":1846.86,"endTime":1848.39,"body":"And this vitamin E is"},{"speaker":"Peter Bowes","startTime":1848.39,"endTime":1853.79,"body":"In terms of your longevity, do you have specific aspirations?"},{"speaker":"Peter Bowes","startTime":1853.79,"endTime":1859.37,"body":"I talk to a lot of people who say and believe very seriously that they can live to 100 or"},{"speaker":"Peter Bowes","startTime":1859.37,"endTime":1866.45,"body":"110 or 120, which is about, I think, the maximum age that people believe that we can live"},{"speaker":"Peter Bowes","startTime":1866.45,"endTime":1869.24,"body":"to considering the current state of science."},{"speaker":"Barrie Tan","startTime":1869.24,"endTime":1876.89,"body":"I think for at least for me, I need to believe in something or someone bigger than me"},{"speaker":"Barrie Tan","startTime":1876.89,"endTime":1880.7,"body":"because I'm finite and I cannot live forever."},{"speaker":"Barrie Tan","startTime":1880.7,"endTime":1887.48,"body":"So to believe in something larger than me and and this is not a telling people what to"},{"speaker":"Barrie Tan","startTime":1887.48,"endTime":1893.27,"body":"be. When I was in New Zealand as a student, I was always raised in a family that is"},{"speaker":"Barrie Tan","startTime":1893.27,"endTime":1896.15,"body":"animistic, maybe a Buddhist and Taoist."},{"speaker":"Barrie Tan","startTime":1896.48,"endTime":1903.05,"body":"But when I was in New Zealand, I learned that there is a place, that there is a God."},{"speaker":"Barrie Tan","startTime":1903.05,"endTime":1905.63,"body":"And then I believe that personally."},{"speaker":"Barrie Tan","startTime":1905.63,"endTime":1912.2,"body":"And over the last 45 years there have been a stay, a very stable rudder in my life."},{"speaker":"Barrie Tan","startTime":1912.2,"endTime":1918.02,"body":"So that would be the you know, I know this is not that a place for me, but since you"},{"speaker":"Barrie Tan","startTime":1918.02,"endTime":1921.94,"body":"asked that would be in my life for that."},{"speaker":"Barrie Tan","startTime":1921.94,"endTime":1930.44,"body":"I think on the material side, because to make our body good and to make our body stay the"},{"speaker":"Barrie Tan","startTime":1930.44,"endTime":1933.93,"body":"same, and it's hard for us to keep the balance."},{"speaker":"Barrie Tan","startTime":1933.95,"endTime":1940.25,"body":"When I was in my twenties, when I was in my fifties and now I'm I will be 70 next year"},{"speaker":"Barrie Tan","startTime":1940.28,"endTime":1948.86,"body":"like that. And for me to have the good mind and to continue to exercise I that I'm doing"},{"speaker":"Barrie Tan","startTime":1949.64,"endTime":1956.06,"body":"and then I'm trying to keep a balance so that my life would not be consuming as much"},{"speaker":"Barrie Tan","startTime":1956.06,"endTime":1959.42,"body":"carbohydrate and fat as I did when I was younger."},{"speaker":"Barrie Tan","startTime":1959.42,"endTime":1962.63,"body":"So that would be more in the material world to do this."},{"speaker":"Barrie Tan","startTime":1962.9,"endTime":1968.15,"body":"The supplement we mentioned that is vitamin E and G G, that's a little different."},{"speaker":"Barrie Tan","startTime":1968.15,"endTime":1971.84,"body":"Those are not normally things that you can find from your normal food."},{"speaker":"Barrie Tan","startTime":1971.84,"endTime":1974.75,"body":"They are more supplemental to your normal food."},{"speaker":"Barrie Tan","startTime":1974.75,"endTime":1978.71,"body":"I do that. I'm also not adverse to medication."},{"speaker":"Barrie Tan","startTime":1978.71,"endTime":1981.32,"body":"If I'm sick, I need to go and see a doctor."},{"speaker":"Barrie Tan","startTime":1981.32,"endTime":1985.64,"body":"I would, but I usually lead on allopathic medicine."},{"speaker":"Barrie Tan","startTime":1985.64,"endTime":1988.01,"body":"What are the side effects?"},{"speaker":"Barrie Tan","startTime":1988.01,"endTime":1995.84,"body":"How how it might interfere in my life so that in understanding that, then I can also take"},{"speaker":"Barrie Tan","startTime":1995.84,"endTime":2000.61,"body":"steps to block those interferences while I'm taking the medicine."},{"speaker":"Barrie Tan","startTime":2000.61,"endTime":2004.3,"body":"So it's an indirect way to answer your question, Peter."},{"speaker":"Peter Bowes","startTime":2004.57,"endTime":2009.13,"body":"And just one final thought and really coming back to where we started, and that is the"},{"speaker":"Peter Bowes","startTime":2009.13,"endTime":2011.26,"body":"importance of vitamins."},{"speaker":"Peter Bowes","startTime":2011.26,"endTime":2015.79,"body":"What do you think of multi-vitamin supplements?"},{"speaker":"Peter Bowes","startTime":2015.79,"endTime":2021.52,"body":"I think that is when people talk about supplementing their diet, a lot of people will opt"},{"speaker":"Peter Bowes","startTime":2021.52,"endTime":2024.55,"body":"for the multi multi-vitamin option because."},{"speaker":"Peter Bowes","startTime":2024.64,"endTime":2028.78,"body":"They believe they're getting essentially a little bit of everything."},{"speaker":"Peter Bowes","startTime":2028.78,"endTime":2033.83,"body":"And it kind of takes the thinking away from figuring out precisely what you need."},{"speaker":"Peter Bowes","startTime":2033.85,"endTime":2038.17,"body":"Well, if I'm taking one of these multi vitamins, I'm probably going to be okay."},{"speaker":"Peter Bowes","startTime":2038.22,"endTime":2039.4,"body":"Is that fair?"},{"speaker":"Barrie Tan","startTime":2039.43,"endTime":2040.66,"body":"That is fair."},{"speaker":"Barrie Tan","startTime":2041.26,"endTime":2043.54,"body":"It's kind of like a catch all."},{"speaker":"Barrie Tan","startTime":2043.66,"endTime":2046.66,"body":"The list is usually about 15 to 20 like that."},{"speaker":"Barrie Tan","startTime":2046.87,"endTime":2050.52,"body":"I have taken multi for a long time."},{"speaker":"Barrie Tan","startTime":2050.53,"endTime":2056.76,"body":"I stopped because of the for vitamin E, They always put TOCOPHEROL and it's not the"},{"speaker":"Barrie Tan","startTime":2056.77,"endTime":2059.84,"body":"vitamin E that I need, but everything else would be okay."},{"speaker":"Barrie Tan","startTime":2059.86,"endTime":2062.86,"body":"Then I finally was able to convince one."},{"speaker":"Barrie Tan","startTime":2063.37,"endTime":2065.51,"body":"So my record is not so good."},{"speaker":"Barrie Tan","startTime":2065.53,"endTime":2071.29,"body":"I was only able to convince one company if they can remove the vitamin E tocopherol and"},{"speaker":"Barrie Tan","startTime":2071.29,"endTime":2073.78,"body":"put tocotrienol I would start to take them."},{"speaker":"Barrie Tan","startTime":2073.78,"endTime":2075.82,"body":"And that company did."},{"speaker":"Barrie Tan","startTime":2076.12,"endTime":2078.93,"body":"Fortunately, it's a health professional company."},{"speaker":"Barrie Tan","startTime":2078.94,"endTime":2080.5,"body":"I'm not even pushing anything."},{"speaker":"Barrie Tan","startTime":2080.74,"endTime":2082.96,"body":"They are called designs for health."},{"speaker":"Barrie Tan","startTime":2082.96,"endTime":2085.42,"body":"And you can go on Amazon you can buy them."},{"speaker":"Barrie Tan","startTime":2085.42,"endTime":2090.16,"body":"They're probably one of the best known, if not the best known health professional"},{"speaker":"Barrie Tan","startTime":2090.16,"endTime":2096.85,"body":"company. They decided to change and I'm taking the multivitamin and when they did my"},{"speaker":"Barrie Tan","startTime":2096.85,"endTime":2103.21,"body":"blood work on the balance of minerals and on all the other B vitamin mine is right on"},{"speaker":"Barrie Tan","startTime":2103.21,"endTime":2109.42,"body":"balance. So I'm very happy to say because I take a multivitamin that have the vitamin E"},{"speaker":"Barrie Tan","startTime":2109.81,"endTime":2111.61,"body":"as tocotrienol, then there is a balance."},{"speaker":"Barrie Tan","startTime":2111.61,"endTime":2113.83,"body":"So thank goodness that's one company."},{"speaker":"Barrie Tan","startTime":2113.83,"endTime":2116.8,"body":"So I'm resuming my taking a multi now."},{"speaker":"Peter Bowes","startTime":2116.89,"endTime":2119.04,"body":"That's a fascinating insight."},{"speaker":"Peter Bowes","startTime":2119.05,"endTime":2121.09,"body":"I really appreciate your time."},{"speaker":"Peter Bowes","startTime":2121.09,"endTime":2123.34,"body":"This has been really interesting conversation."},{"speaker":"Peter Bowes","startTime":2123.34,"endTime":2126.58,"body":"And as you have implied, there is much more to learn."},{"speaker":"Peter Bowes","startTime":2126.58,"endTime":2128.59,"body":"And you've mentioned your website."},{"speaker":"Peter Bowes","startTime":2128.59,"endTime":2134.17,"body":"I will put some more details of that website into the show notes for this episode, and"},{"speaker":"Peter Bowes","startTime":2134.17,"endTime":2142.51,"body":"you can find those at the LLAMA podcast website that's LLAMApodcast.com And it is worth"},{"speaker":"Peter Bowes","startTime":2142.51,"endTime":2148.3,"body":"taking the time, I think, isn't it, to dive deep and just try to figure out the fact that"},{"speaker":"Peter Bowes","startTime":2148.3,"endTime":2153.1,"body":"issues are quite as simple as we sometimes think they might be or even hope they might"},{"speaker":"Peter Bowes","startTime":2153.1,"endTime":2158.89,"body":"be, that when you referring to one single vitamin, it is worth diving a little deeper to"},{"speaker":"Peter Bowes","startTime":2158.89,"endTime":2162.52,"body":"figure out what is best, what you need, and what the way forward is."},{"speaker":"Barrie Tan","startTime":2162.64,"endTime":2164.56,"body":"Thank you so much for inviting me."},{"speaker":"Barrie Tan","startTime":2164.56,"endTime":2167.38,"body":"I've done hundreds of podcasts."},{"speaker":"Barrie Tan","startTime":2167.38,"endTime":2172.79,"body":"I said something good about your podcast, Peter, and you didn't ask me to do it."},{"speaker":"Barrie Tan","startTime":2172.81,"endTime":2179.8,"body":"I think there is a sense in your podcast, Peter, you you have an ownership of sincerity."},{"speaker":"Barrie Tan","startTime":2179.8,"endTime":2185.89,"body":"I think that your listener will stay with you for a long time, and as I'm doing the same,"},{"speaker":"Barrie Tan","startTime":2185.89,"endTime":2191.5,"body":"I want it to bear out information to people that to my best of my knowledge, that they"},{"speaker":"Barrie Tan","startTime":2191.5,"endTime":2193.42,"body":"are germane and are true."},{"speaker":"Barrie Tan","startTime":2193.42,"endTime":2199.18,"body":"And if anything is not sure, I simply withhold and not comment or I say I don't know."},{"speaker":"Barrie Tan","startTime":2199.18,"endTime":2201.63,"body":"So blessings to all your listener."},{"speaker":"Barrie Tan","startTime":2201.64,"endTime":2202.87,"body":"That listen to you."},{"speaker":"Barrie Tan","startTime":2202.9,"endTime":2209.29,"body":"Hopefully you'll find some nugget of truth in something that I say in other things that"},{"speaker":"Barrie Tan","startTime":2209.29,"endTime":2210.88,"body":"you don't get to hear."},{"speaker":"Barrie Tan","startTime":2210.88,"endTime":2215.2,"body":"Just come to a website of mine and then you can download whatever white papers that we"},{"speaker":"Barrie Tan","startTime":2215.2,"endTime":2216.85,"body":"have. Thank you again."},{"speaker":"Peter Bowes","startTime":2217.12,"endTime":2220.66,"body":"You're very kind and I am very grateful to you for your time."},{"speaker":"Peter Bowes","startTime":2220.66,"endTime":2223.21,"body":"Dr. Barrie Tan, thank you very much indeed."},{"speaker":"Barrie Tan","startTime":2223.21,"endTime":2223.93,"body":"Thank you."},{"speaker":"Peter Bowes","startTime":2224.17,"endTime":2226.6,"body":"This has been a HealthSpan Media production."},{"speaker":"Peter Bowes","startTime":2226.6,"endTime":2232.54,"body":"You can contact me by direct message @PeterBowes or email peter@LLAMApodcast."},{"speaker":"Peter Bowes","startTime":2233.11,"endTime":2237.28,"body":"It's always good to hear your feedback on the interviews that we do."},{"speaker":"Peter Bowes","startTime":2237.31,"endTime":2238.45,"body":"Thank you so much for listening."}]}