Francis Couturaud joins Chloe Wilson of The Lancet to discuss the RENOVE trial, which looks at assessing the efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated.

Read the full paper: 
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02842-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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This week, we discuss treatment approaches for uncomplicated appendicitis in children following the publication of a trial in our January 18th issue. Lead author Shawn St Peter, general paediatric surgeon and surgeon-in-chief at Children’s Mercy Hospital, Kansas City, spoke with Callam Davidson about the motivation behind the study, key findings, and what the results mean for clinical practice.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02420-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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Michael Heneka joins Chloe Wilson and Bea Gomez Perez-Nievas of The Lancet to discuss a therapeutics paper discussing the opportunities and challenges of passive anti-amyloid β immunotherapy in Alzheimer's disease.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01883-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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ROSHNI-2 was a multicentre, randomised controlled trial that investigated the efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women. Joining us to share their expertise and perspectives are chief investigator Professor Nusrat Husain, trial manager Farah Lunat, and service user representative Fehmida Motala.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01612-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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Rasha Al-Lamee and Shayna Chotai join Chloe Wilson of The Lancet to discuss ESC Congress 2024 highlights.

The papers featured on this podcast are:

1) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01733-1/fulltext
2) https://www.nejm.org/doi/abs/10.1056/NEJMoa2409134
3) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01454-5/abstract
4) https://www.nejm.org/doi/abs/10.1056/NEJMoa2314328
5) https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Elevated-Blood-Pressure-and-Hypertension
6) https://www.jacc.org/doi/10.1016/j.jacc.2024.08.027

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On August 14th, the World Health Organisation declared a public health emergency of international concern in relation to mpox. This was motivated, in part, by the emergence of a concerning new strain of mpox, clade 1b, which has spread rapidly across Central Africa. Joining me this week to discuss important clinical aspects of the current mpox outbreak are Dr Oriol Mitja, Associate Professor at the Germans Trias Research Institute in Barcelona, and Dr Hypolite Muhindo Mavoko from the Department of Tropical Medicine at the University of Kinshasa.

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Natasha Pocovi joins Chloe Wilson of The Lancet to discuss a trial investigating a walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack).

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00755-4?dgcid=buzzsprout_tlv_podcast_generic_lancet

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Prasad Kulkarni joins Callam Davidson of The Lancet to discuss the safety and immunogenicity of a bivalent conjugate vaccine against typhoid and paratyphoid, following the publication of a phase 1 trial.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00249-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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Patricia Campbell and Frans Rutten join Chloe Wilson for an educationally-focused podcast, discussing the key messages for clinical practice on heart failure with preserved ejection fraction.

Read the full Seminar:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02756-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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Lene Seidler joins Callam Davidson of The Lancet to discuss umbilical cord clamping strategies at preterm birth following the publication of two systemic review and meta-analyses with individual participant data.

Read the full articles:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02468-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02469-8/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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Emily Chew joins Chloe Wilson of The Lancet to discuss the future of treatments for geographic atrophy following the publication of two randomised controlled trials of new drug treatments.

Read the full article here:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01583-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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Simon Kyle joins Gavin Cleaver of The Lancet to discuss his paper on sleep restriction therapy as a new effective treatment for insomnia.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00683-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

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On this International Women's Day,  Lancet editors and the co-chairs of the Women and Cancer Commission discuss the burden of women’s cancer on society and reflect on the questions the Commission is trying to answer. 

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Nick James discusses the key messages of the recent report from the STAMPEDE trial platform and the success of this platform in advancing the treatment of prostate cancer 

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《柳叶刀》亚洲执行主编王辉对话《柳叶刀中国女性生殖、孕产妇、新生儿、儿童和青少年健康重大报告》共同主席乔杰院士。

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Helena Wang discusses The Lancet Commission on women's reproductive, maternal, newborn, child and adolescent health (RMNCAH) in China with author Professor Jie Qiao.

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Siobhan Quenby & Arri Coomarasamy discuss the key findings from The Lancet's new Series on miscarriage.

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On the 50th anniversary of the Inverse Care Law, Professor Sir Muir Gray joins Gavin Cleaver to discuss the continuing importance of the ICL, and notions of value and quality in health care.

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The Lancet's new Commission, Public Policy and Health in the Trump Era, looks back at the effects of the last four years on the health of the USA. One of the authors of the Commission, Mary Bassett (Harvard University) joins us to talk about the Commission findings and wider issues facing the USA.

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Editor-in-chief of The Lancet, Richard Horton, discusses the results of the Oxford vaccine's phase 3 trial.

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Renee Salas, leader of the Lancet Countdown policy brief in the US, discusses the climate problems facing the US, the issues of the last four years, and the reasons to be optimistic about the future.

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Universal health coverage (UHC) is a vital facet of healthcare across the world, and a new Global Burden of Disease paper seeks to measure its spread. The Lancet spoke with  author Rafael Lozano and linked Comment author Margaret Kruk about efforts to analyse and measure UHC.

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The Lancet Editor-in-Chief Richard Horton explains the current status of the Oxford and China COVID-19 vaccines, including an overview of current progress and the next steps for both.

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The new Global Burden of Disease paper forecasts major alterations in worldwide population over the next few decades. We ask Kathleen O’Reilly, of LSHTM, how models are made and how you account for a changing world, and we speak with paper author Stein Emil Vollset of IHME about the implications of his predictions.

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Professor Rosanna Peeling discusses the implications of seroprevalence results from recent COVID-19 antibody studies.

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