Business Trip
Business Trip tells the story of businesses at the frontier of mental health and brain health. Each episode features founders, investors, and researchers in psychedelics, neurotechnology, metabolic psychiatry, digital therapeutics, and more.
Business Trip
Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron
Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer’s trials.
In this episode, we discuss:
- How skin-derived cells can be turned into neurons to repair the brain.
- Why replacing lost neurons may succeed where drugs have failed in Alzheimer’s.
- What makes autologous (self-derived) cell therapy safer and more effective.
- How testing in dogs brought stronger proof than traditional mouse models.
- Why this approach could shift Alzheimer’s treatment from slowing decline to restoring memory.
Credits:
Created by Greg Kubin and Matias Serebrinsky
Host: Matias Serebrinsky & Greg Kubin
Produced by Caitlin Ner & Nico V. Rey
Find us at businesstrip.fm and psymed.ventures
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Theme music by Dorian Love
Additional Music: Distant Daze by Zack Frank