Habit Change Anxiety - Personalizing Anxiety Treatment: The Science of Psychological Phenotyping Artwork

The Dr. Jud Podcast

Welcome to the Dr. Jud podcast. I am an addiction psychiatrist and neuroscientist. My lab first at Yale and now at Brown University has been researching how our brains form negative behavior patterns, bad habits and addictions, and the specific techniques needed to create lasting change. My aim with this podcast, is to use every day issues that we all struggle with from anxiety to emotional eating to self judgment to help us understand how our minds work so that we can put them to work for us. I'll show you how you can use your brain to overcome the habits and “everyday addictions” that are holding you back. And along the way, you'll learn how helping yourself can help create a kinder and more compassionate world. Thank you for your interest in learning how to work with your mind.-Dr. Jud Brewer

All Episodes

The Dr. Jud Podcast

Habit Change Anxiety - Personalizing Anxiety Treatment: The Science of Psychological Phenotyping

March 22, 2025 • Dr. Jud Brewer

Cluster-Based Psychological Phenotyping and Differences in Anxiety Treatment Outcomes

In this episode, Dr. Jud Brewer and colleagues explore how machine learning and psychological phenotyping can optimize treatment for anxiety disorders. Through a groundbreaking study involving app-based mindfulness training, participants were grouped into three psychological phenotypes: "severely anxious with body/emotional awareness," "body/emotionally unaware," and "non-reactive and aware." The study demonstrates how cluster membership significantly influences treatment outcomes, with two phenotypes showing marked improvements in anxiety symptoms. This research sets the stage for personalized medicine in mental health, offering low-cost, scalable solutions to match individuals with tailored interventions for better results.

Full Reference:
Taylor, V. A., Roy, A., & Brewer, J. A. (2023). Cluster-based psychological phenotyping and differences in anxiety treatment outcomes. Scientific Reports, 13, 3055. https://doi.org/10.1038/s41598-023-28660-7

Let's connect on Instagram