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Mind & Matter

Nick Jikomes

Whether food, drugs or ideas, what you consume influences who you become. Learn directly from the best scientists & thinkers alive today about how your mind-body reacts to what you feed it.

The weekly M&M podcast features conversations with the most interesting scientists, thinkers, and technology entrepreneurs alive today.


Not medical advice.

At M&M, we are interested in trying to figure out how things work, not affirming our existing beliefs. We prefer consulting primary rather than secondary sources and independent rather than institutional voices. If we encounter uncomfortable truths or the evidence suggests unfashionable ideas may be valid, so be it.


As the host, my aim is to help you better understand how the body & mind work by curating & synthesizing information in a way that yields science-based insights that you can choose to use or disregard in your own life. Taking ownership of your health starts with taking ownership of your information diet.


I am motivated to connect the dots and distill general principles from what I learn, preferring to ask questions and play devil’s advocate to debating or incessantly pushing my own viewpoint.


My beliefs:


Sometimes modern discoveries teach us we must unlearn received wisdom. Other times, modern information overload & historical chauvinism cause us to forget ancient wisdom which stills applies. The framework for learning that I embody is inspired by three Ancient Greek maxims inscribed in the Temple of Apollo at Delphi:

  • “Γνῶθι σεαυτόν” (Know thyself)
  • “Μηδὲν ἄγαν” (Nothing in excess)
  • “Ἐγγύα πάρα δ Ἄτα” (Certainty brings insanity)
Evolution & Genetics of Human Diet, Metabolism, Disease Risk, Skin Color & Origins of Modern Europeans | Eske Willerslev | #154April 24, 2024
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Diet, Nutrition, Metabolic Psychiatry, Brain & Mental Health | Georgia Ede | #153April 19, 2024
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Plant Chemistry, Cannabinoids, Cannabis Terpenes & the Entourage Effect | Ryan Vandrey | #152April 12, 2024
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Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | #151April 07, 2024
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Visual System, Visual Impairments & Cures, Amblyopia, Neuroplasticity, Critical Periods & Metaplasticity, Ketamine & Psychedelics | Mark Bear | #150April 03, 2024
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DNA & RNA Biology, mRNA Vaccines, Vax Contamination & Side Effects, Spike Protein, Ivermectin, Hop Latent Viroid | Kevin McKernan | #149March 30, 2024
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Dietary Protein, Muscle Growth, Resistance Training, Amino Acids, Plant vs. Animal Protein Sources, Anabolic Growth | Luc van Loon | #148March 27, 2024
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Ketamine: Opioid System, Sex Differences, S- vs. R- Isomers, Depression & Ultrasound Imaging Technology | Tommaso Di Ianni | #147March 22, 2024
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Photobiology, Sunlight, Firelight, Incandescent Bulbs vs. LEDs, Mitochondria, Melatonin, Sunscreen & the Optics of the Body | Scott Zimmerman | #146March 19, 2024
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Epigenetics, Hormones, Endocrine Disruptors, Microplastics, Xenoestrogens, Obesogens & Obesity, Inheritance of Acquired Characteristics | Bruce Blumberg | #145March 14, 2024
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Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant | #144March 10, 2024
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Gut-Brain Communication, Vagus Nerve, Fats & Sugars, Food Addiction, Gut Hormones & Weight Loss Drugs | Will de Lartigue | #143March 05, 2024
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Endogenous DMT in the Mammalian Brain | Nicolas Glynos | #142February 29, 2024
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Evolution, Language, Domestication, Symbolic Cognition, AI & Large Language Models | Terrence Deacon | #141February 24, 2024
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Obesogens, Oxidative Stress, Dietary Sugars & Fats, Statins, Diabetes & the True Causes of Metabolic Dysfunction & Chronic Disease | Robert Lustig | #140February 17, 2024
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Metabolic Switching, Fasting, Ketosis, Neuroplasticity, Diet & Neurodegenerative Disease | Mark Mattson | #139February 14, 2024
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Evolution & Animal Development: How Nature Builds & Changes Bodies | Sean B. Carroll | #138February 09, 2024
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DMT, Serotonin, Inflammation, Psychedelics, and Past, Present & Future of Psychedelic Medicine | David & Charles Nichols | #137February 05, 2024
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Seed Oils, Omega-6 Fats, Inflammation, Obesity, Diabetes, Chronic Disease & Metabolic Dysfunction | Chris Knobbe | #136January 22, 2024
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History of Diet Trends & Medical Advice in the US, Fat & Cholesterol, Seed Oils, Processed Food, Ketogenic Diet, Can We Trust Public Health Institutions? | Orrin Devinsky | #135January 10, 2024
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Omega-6-9 Fats, Vegetable & Seed Oils, Sugar, Processed Food, Metabolic Health & Dietary Origins of Chronic Inflammatory Disease | Artemis Simopoulos | #134January 03, 2024
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Infant Microbiome & Breast Milk, Oral Microbiome & Cavities, Gut Health, Fiber, Probiotics, Diet, Sex Hormones, Soy Foods & Estrogens | Carolina Tropini | #133December 20, 2023
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Obesity Epidemic, Diet, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & Feeding Behavior | John Speakman | #132December 05, 2023
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Dietary Fat, Cholesterol, Cardiovascular Health & Disease, Carbohydrates, Dietary Guidelines, Food Industry & Diet Research | Ronald Krauss | #131December 04, 2023
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Cognitive Neuroscience, Cognitive Flexibility & Control, Attention, Working Memory, Multitasking & Behavior | Tobias Egner | #130November 05, 2023
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