The Stem Cell Report with Janet Rossant
Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Rossant goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.
Episodes
43 episodes
Crossing the Border: Modeling the Blood Brain Barrier
The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human stem-cell-based mo...
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Season 4
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Episode 7
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29:52
Movin’ On Out: Mobilizing HSCs From The Bone Marrow
Hematopoietic stem cells (HSCs) normally reside in the bone marrow niche but can traffic across the bone marrow endothelium into the bloodstream to populate different niches. This process of HSC mobilization from the bone marrow to the blood, i...
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Season 4
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Episode 6
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33:22
Cancer Neuroscience, Tumor Organoids, and Understanding the Role of the Nervous System in Human Glioblastoma
The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and migration of gliomas, a glial-derived tumor of the CNS, via diffu...
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Season 4
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Episode 5
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45:34
Stem Cells in Space: Muscle Regeneration in Microgravity
Skeletal muscle is one of the most abundant tissues in the human body, representing approximately 40% of body weight. Under certain circumstances, skeletal muscle can be regenerated through satellite cells, a reservoir of quiescent muscle stem ...
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Season 4
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Episode 4
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39:52
Parkinson's Disease, Cell Therapy, and Exercise
The potential of pluripotent stem cells and the ability to scale and differentiate them to generate large numbers of enriched cell populations has created new opportunities and approaches to treat human disease. Preclinical proof-of-principle d...
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Season 4
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Episode 3
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38:33
Leaving an Imprint: The Function, Impact, and Detection of Epigenetic Marks
Parent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and maintenance are not fully understood. In humans, approximately 200 i...
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Season 4
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Episode 2
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54:08
Don’t Dull the SPARCL: The Lung Microvasculature and its Role in Development
The mature lung in both humans and mice is highly vascularized, with approximately 30% of all cells being endothelial cells (ECs). The blood vessels have a physiological role in gas exchange within the tissue, but the vascular cells have additi...
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Season 4
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Episode 1
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43:27
A Look Into the Future of Stem Cell Reports: A Conversation with Janet Rossant
In this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what she sees as some of the exciting prospects over the horizon for stem cell ...
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Season 3
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Episode 14
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57:40
SeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality Assessment
During the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological questions. However, abnormalities in cell lines such as aneuploidy, ...
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Season 3
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Episode 13
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34:28
Guidelines for Managing and Using the Digital Phenotypes of Pluripotent Stem Cell Lines
The ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development and disease. As a result, these cells are shared, edited, and differentiat...
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Season 3
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Episode 12
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53:47
PSC Developmental Bias: The Mechanism and the Variation in Human Neural Development
Pluripotent stem cells are defined, in part, by their potential to generate cell types from all three embryonic germ layers. However, it is well known within the field that there is variability in developmental potential between cell lines. Thi...
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Season 3
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Episode 11
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42:54
Aging, Stem Cells, and Biological Clocks
Epigenetic clocks based on tissue DNA methylation analysis have emerged as robust and powerful biomarkers of aging. This technology has allowed scientists to investigate how diseases affect the aging process, to evaluate the effectiveness...
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Season 3
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Episode 10
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39:52
Evaluating the Expanding Models of Brain Disease
Those who study neurological diseases and their underlying cellular and molecular mechanisms have a number of scientific models at their disposal. In vivo animal models, particularly those bearing targeted genetic modifications, remain the gold...
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Season 3
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Episode 9
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51:38
Going Out on a LIM: Rethinking the Role of LMX1A in Patterning Dopaminergic Neurons
This episode of The Stem Cell Report will discuss the process of directing stem cells to acquire the proper identity, an essential step in the development of effective and durable cell replacement therapies. Specifically, we will talk about the...
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Season 3
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Episode 8
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30:40
No Oligo Monopoly: Oligodendrocyte Precursor Cells in the Developing Cortex
Myelination is one of the last events during mammalian brain development and is thought to continue into young adulthood in humans. Even in adulthood, ongoing low-level myelination is essential for neural homeostasis, and for dynamic processes ...
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Season 3
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Episode 7
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37:49
Enhancing Connections: Rebuilding Neural Circuits in Spinal Cord Injury
Biomedical researchers have long sought ways to repair spinal cord damage with the holy grail of the pursuit being the reconstitution of lost function. In the mid 1990’s with the successful culture of human embryonic stem cells, and about a dec...
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Season 3
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Episode 6
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24:35
Climbing the Scientific Mountain of Retinal Regeneration
Collectively, retinal degenerative disorders are a major cause of blindness worldwide. For example, one of the most common disorders is age related macular degeneration, which alone affects nearly 200 million globally. In humans, an...
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Season 3
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Episode 5
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43:07
Human Fetal Tissue: A Legacy of Biomedical Research Contributions
Since the 1930’s research using human fetal tissue has been used in numerous scientific and medical advances that have saved millions of lives, including the development of vaccines and treatments for diseases. Despite its substantial contribut...
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Season 3
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Episode 4
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37:32
The Selling of Stem Cells
This November marks the 25th anniversary of the successful isolation and culture of human embryonic stem cells by Jamie Thompson. This breakthrough was a turning point in biomedical research. This discovery provided scientists with a limi...
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Season 3
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Episode 3
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48:39
Setting the Standards for Human Stem Cell Research
Human stem cell technology has led to remarkable insights into human biology in health and disease. However, for the results and outputs from this research to be accurate, meaningful, and durable, it is important that the field have agreed upon...
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Season 3
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Episode 2
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52:44
Organoids: Multi-Dimensional Standards for Three Dimensional Models
The use of organoids as an experimental system is rapidly advancing in pace and complexity. Derived from pluripotent or tissue stem cells, organoids are three-dimensional, in vitro, structures intended to model functional or developmental aspec...
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Season 3
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Episode 1
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38:51
Brushing Up on Tooth Biology: New Tools for Understanding Tooth Development
While teeth have evolved over millions of years, scientists are still working to understand how teeth develop, a process formally known as Odontogenesis. Our guests today have developed a new model of mouse tooth development using long-term exp...
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Season 2
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Episode 10
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54:24
The Satellite View: Muscle Stem Cells and Muscle Disease
Over the last 10 years of Stem Cell Reports, the journal has published nearly 2,000 papers across the breadth of stem cell research. In this special episode of the podcast, we are celebrating the anniversary of the journal by talking w...
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Season 2
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Episode 9
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35:33
Focusing on the Aberration: Learning From PSCs Chromosomal Abnormalities
Human pluripotent stem cells have an unlimited capacity to self-renew in culture. This feature, along with their ability to become any cell type in the adult body, makes them a unique tool to study human biology in health and disease. Unfortuna...
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Season 2
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Episode 8
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48:34
PiWi – The Not-So-Small and Expanding Role of RNA Binding Proteins
The PiWi family of genes may have a diminutive sounding name, but they have a large role in the function of the germline and germline stem cells. Initially discovered in Drosophila, these highly conserved RNA-binding proteins have well...
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Season 2
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Episode 7
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39:54