Alexander Disease Research Update
Albee Messing
Monthly discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.
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Episodes
Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation
September 08, 2023
Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab
August 07, 2023
Alexander Disease Research Update - Episode #15: subclassifications of Type I; questions regarding 1) mesenchymal stem cells and 2) the intransasal route of delivery
April 05, 2023
Alexander Disease Research Update - Episode #14: whole exome/genome sequencing; more questions on the brainstem
November 12, 2022
Alexander Disease Research Update - Episode #13: MRI diffusion tractography - what can it tell us?
October 13, 2022
Alexander Disease Research Update - Episode #12: GFAP variants and oxidative stress/mitochondrial dysfunction; commentary on dizziness, risks of brain biopsies
September 01, 2022
Alexander Disease Research Update - Episode #11: neurology 101 (location, location, location), discussion on the autonomic nervous system
August 05, 2022
Alexander Disease Research Update - Episode #10: effects of variants in the rod domain on GFAP assembly and aggregation, new ideas about functions of intermediate filaments
June 09, 2022
Alexander Disease Research Update - Episode #9: new mechanisms of astrocyte dysfunction, case report with novel variant, commentary on head trauma as an aggravating factor
April 12, 2022
Alexander Disease Research Update - Episode #8 - two case reports, natural history study of 21 pediatric patients, management of constipation
March 06, 2022
Alexander Disease Research Update - Episode #7 - common drugs tested in cell culture model; germline mosaicism vs de novo variants; electronic health records in research
January 27, 2022
Alexander Disease Research Update - Episode #6 - silent mutations, case report, new rat model, mouse proteomics
January 04, 2022
Alexander Disease Research Update - Episode #5 - case report with silent mutation and area postrema syndrome; neuropsychological testing
December 04, 2021
Alexander Disease Research Update - Episode #4 - case report, clinical trials
October 26, 2021
Alexander Disease Research Update - Episode #3: crossing the blood-brain barrier
September 16, 2021
Alexander Disease Research Update - Episode #2: tumor-like lesions; very-late onset
August 13, 2021
Alexander Disease Research Update - Episode #1: genetic anticipation?
July 15, 2021
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