Villages Vitality: Senior Life Unscripted
This weekly podcast will cover in detail, people, clubs and activities here in The Villages, Florida. Each show will run 20-30 minutes. We cover topics of interest to active, vital seniors. Topics range form activites to medical topics, from Alzheimer's to Zomba and everything in between of interest to seniors.
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Villages Vitality: Senior Life Unscripted
Unlocking The Secrets of Longevity with Dr. Sandra Kaufmann
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Season 8: Dr. Sandra Kaufmann on Cellular Aging, NAD, Exosomes, and a Simple Supplement “Panaccea”
In the Season 8 premiere of Villages Vitality Life: Senior Life Unscripted, host Mike Roth talks with Dr. Sandra Kaufmann, a longevity medicine physician and author of The Kaufmann Protocol: Why We Age and How to Stop It and Aging Solutions, about aging from a cellular perspective and how to slow it through proactive, personalized strategies. Kaufmann explains her “seven tenets of aging,” why there is no single magic bullet, and why aging begins as early as 30–35 as key pathways and hormones decline. She outlines practical starting points (mindset, diet, exercise, addressing basic medical problems) and highlights NAD precursors (NR or NMN) as an accessible over-the-counter supplement to support energy and DNA repair. The conversation also covers tiered approaches to medicine, cancer risk as DNA repair failure, the role of peptides as accessories, and exosomes as a lower-risk, more effective regenerative option than stem cells. Kaufmann closes with her five-supplement “PANACCEA” stack (pterostilbene, astaxanthin, NAD precursor, bioavailable curcumin, and carnosine) and shares how to learn more via kaufmannprotocol.com and kaufmannlongevity.com.
Chapters
- 0:08 - Introduction
- 0:43 - Meet Dr. Sandra Kaufmann
- 1:59 - Motivation for Anti-Aging
- 2:44 - Why Do We Age?
- 4:15 - Mindset and Longevity Pyramids
- 7:15 - When Does Aging Begin?
- 8:22 - The Importance of NAD Precursors
- 10:21 - Alzheimer's Medical Tip
- 12:13 - The Three Tiers of Medicine
- 13:40 - DNA Damage and Cancer
- 15:09 - Peptides, Stem Cells, and Exosomes
- 18:20 - Cost and Results of Longevity Medicine
- 19:57 - Starting the Longevity Process
- 21:44 - Genetics vs. Lifestyle
- 25:26 - The PANACCEA Supplements
- 27:57 - Outro
Villages Vitality Listeners, I've got some good news for you. In season 8 most new episodes will released as both audio & video versions. Videos on Apple Podcasts, Busssprout.com and YouTube. If you're listening via our Buzzsprout feed, you can ask questions via the Fan Mail button or leave me comments as a text or in our new feature, you can send it as a voicemail. If you'd like a response, make sure you leave your name, email address and cell phone number.
Open Forum in The Villages, Florida is Produced & Directed by Mike Roth
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Welcome to Season eight of Villages Vitality Life, seniors Life unscripted. In this new season, we talk to leaders of clubs and interesting folks who live in and around The Villages. We also talk to people who have information vital to seniors. You will get perspectives of what is happening in and around The Villages, Florida, in addition. We will add more information for all seniors. We are a listener supported podcast.
Mike (4):This is Mike Roth on Villages Vitality, Senior Life Unscripted. I'm here today with Dr. Sandra Kaufman. Thanks for joining me, Sandra
Dr. Sanda Kaufmann:It is my pleasure to be here
Mike (4):Dr. Sandra Kaufmann is a global leader in longevity medicine, an impressive scientific background in cellular biology and anesthesiology with a deep commitment to advancing the science of aging. Dr. Kaufmann is best known for her groundbreaking work as an author and creator of the Kaufmann Protocol, a comprehensive framework that systematically categorizes cellular aging and offers strategy to mitigate it. At the heart of this framework is the Kaufmann Rating System, unique methodology that assesses and recommends evidence-based supplements, helping individuals make informed choices to optimize their health span. Two influential books are The Kaufmann Protocol: Why We Age and How to Stop It, and the second book is Aging Solutions. She currently has offices in Miami and in Las Vegas. Dr. Kaufmann, how long has the newer book been out?
Dr. Sanda Kaufmann:Three years
Mike (4):About three years. And what motivated you to create a protocol anti-aging?
Dr. Sanda Kaufmann:I'd love to say that I, wanna help humanity, but to be perfectly frank, I did it because I didn't want to age. I have a background in cell biology. I've done… I have a liberal arts education in medicine. I did some surgery. I did some neurosurgery. I'm an anesthesiologist. So I think I'm sitting in a unique position to figure out why our bodies age from a cellular perspective, and I got tired of aging, and I set out to figure it out, to categorize it, and then to come up with solutions.
Mike (4):Great. It sounds like it should be a bestseller. Now me ask you a few questions about aging. Why do we age?
Dr. Sanda Kaufmann:What's humorous about the question is if you ask a million people, they're gonna give you a million different answers. To me, because I started my scientific world as a cell biologist, I think that you age because your cells age, and your cells are little factories. And I think y- from a scientific basis, like that's all we are. We are a cluster of cells and cell products, and I don't like to get into arguments about the soul or the reason of being and all the sort of metaphysical stuff like… But from a very solid scientific cellular basis, we are cells, and cells become dysfunctional over time. And if you can make some of that dysfunction be better, then you are better off overall
Mike (4):I was under the impression that as we age, our cells dendrites a- at the end don't reproduce as accurately as they did when we were younger. Is that true?
Dr. Sanda Kaufmann:Yeah. In a very simplistic fashion, that is one of the reasons that cells age. But the reasons are numerous. I categorize them by what I call the seven tenets of aging, and then there are of course very specific subcategories. So there is never going to be one magic bullet because you need to effectively approach all of the different reasons to truly decelerate aging
Mike (4):Okay. How can we alter the process of aging?
Dr. Sanda Kaufmann:What, you gotta fix yourself?
Mike (4):think young
Dr. Sanda Kaufmann:No, but honestly mindset is huge, right? There's a discrete difference between people who have a young frame of reference and an old frame of reference, and I'm sure that, every day. There are people in their 60- yeah, their 60s and 70s, and some people are out playing pickleball or tennis or swimming or doing whatever, and other people are just sitting around waiting to die. So mindset is absolutely a huge part of it. But then once you decide that you're going to be active and chasing life there's just many ways to do it, and one of the things that I do is I design longevity pyramids for people, and these are things that you do every day, every week, every month, so on and so forth. And stuff that's easy to do every day, of course, is, optimizing your diet, optimizing exercise. There are longevity supplements. There are longevity medications, and then there's all lots of accessory things you can do, right? Saunas and cold baths and light therapies. So there are innumerable ways to approach this, and people can either do one or two simple things, or they can, as I say, fall into the abyss of longevity and do everything
Mike (4):I think our genes come , into play very, heavily. And the other thing that I've seen is when people have conditions which cause pain, which hurts their mobility they tend to age more rapidly. How does someone know where to start the process of trying to control aging?
Dr. Sanda Kaufmann:That's a good question, and I think it very much depends on who the person is. So as an example, if someone is an absolute couch potato, they should just get off the couch, step one, right? If someone just eats a lot of cake and pie every day, maybe you start by eliminating that. Simple stuff, right? In terms of medical issues, you want to make sure you are adequately addressing medical issues prior to going into true longevity. And the reason I say this, and it's ironic. I, I've been an anesthesiologist for a million years, and we have these older patients that come to the hospital, and they're furious that we diagnose them with problems. And I, I can't tell you how many times I have heard people say I was fine before I walked into the hospital, and now I have high blood pressure, and heart disease, and blah, blah, blah, blah, blah." the answer is we didn't give it to them. They had it. They just didn't know it. So the first step
Mike (4):Undiagnosed
Dr. Sanda Kaufmann:is making sure you're taking care of your basic health issues
Mike (4):Okay and that, that would involve having a very good primary care physician. Unfortunately there are few of those. Someone start working on their longevity as a goal? Is there an age that,
Dr. Sanda Kaufmann:Yeah, you're,
Mike (4):should kick in?
Dr. Sanda Kaufmann:yeah, you're not gonna like this, but people start aging between 30 and 35
Mike (4):No, you're right. I didn't like it.
Dr. Sanda Kaufmann:Yeah, I know. No one does. So for example, levels of very important components in your body start dropping w- in your early 30s. Estrogen starts dropping, DHEA starts dropping, pregnenolone starts dropping. By the time you hit 35, s- your sirtuins start dropping and you're like, "What the hell is a sirtuin?" Pardon my language. But there are pathways in your body that start failing starting at 35-ish and continuing on. So by the time you hit 40, 45, 50, you are well into the aging process, and unfortunately people don't realize it until you're behind the eight ball. On the other hand, I don't wanna discourage people from chasing longevity because even if I can't give you more years, I can give you better years
Mike (4):Can you give our listeners an example of a supplement that they might take help the effects of aging?
Dr. Sanda Kaufmann:Oh gosh, yes. So probably the easiest one for people to take is gonna be an NAD precursor. And what is that?
Mike (4):A what?
Dr. Sanda Kaufmann:An NAD precursor. So I'm gonna … All right,
Mike (4):NAD
Dr. Sanda Kaufmann:I'm gonna explain this. NAD is a molecule that stands for nicotinamide adenine dinucleotide, and this is a molecule that is massively needed in your body. You use it for four different places in energy production in your mitochondria, and you use it as a cofactor for 500 different reactions in a cell. And you need more as you get older, and you make less. So by the time you're hitting 40, 45, you are deficient, right? And interestingly enough, DNA repair mechanisms, these are mechanisms that help prevent cancer, require NAD. So the easiest, lowest hanging fruit is to replenish your amount of NAD, right? But swallowing NAD doesn't really work very well because there aren't any receptors, and I won't bore you with the details. But you have to take a molecule that your body turns into NAD, and there's two essential
Mike (4):sense
Dr. Sanda Kaufmann:There's something called NR, which is nicotinamide riboside, or NMN, which is nicotinamide mononucleotide. And these are just pills that you take every day, and within two to three weeks of doing this, your energy levels are much improved, and your life is just much improved. So that is an absolutely easy slam dunk, everyone should do it supplement
Mike (4):It's interesting because I've never heard of it. is it a prescription drug?
Dr. Sanda Kaufmann:Nope. Completely over the counter
Mike (4):Wow. That's a big tip. Okay, we're gonna take a a short break and listen to an Alzheimer's tip from Dr. Craig Curtis. we'll be back in about a minute
Mike:There have been some studies that people have talked about using GLP one drugs to help Alzheimer's. What, what's the story on that?
Dr. Craig Curtis:So that was breaking news a few months ago. They released the results that showed it was not a positive study, which means there was no statistical difference between the placebo group and those that received GLP ones for the length of the trial, which was approximately two years. Now. What they did find is that those. On the GLP ones did have trending biomarkers. The levels of tau and amyloid seem to be moving in the right direction, so it's possible they didn't receive the treatment long enough. Maybe a two year trial was not enough, sort of what we just referenced in hyperbaric oxygen. Maybe you need it for a longer amount of time. Yeah, longer than three months. Longer than. Three months. So there's going to be more data released at a big meeting coming up in Copenhagen in March that I'll be attending, called the Alzheimer's PD International Parkinson's Disease International Meeting. And they're going to release more information about the biomarkers, in that study and whether or not they will do more. So stay tuned. I don't think they quite have answers yet, but the overall study was. A failure if you wanna look at it from a totality or the study in full. Yeah.
Mike:But the study kind of indicates from what you're saying, that they need an additional study to go beyond two years.
Warren:With over 20 years of experience studying brain health, Dr. Curtis's goal is to educate The Villages community on how to live a longer, healthier life. To learn more, visit his website, CraigCurtisMD.com, or call 3 5 2 5 0 0 5 2 5 2 to attend a free seminar.
Mike (4):Thank you, Dr. Curtis. That, that, Dr. Kaufman, you gave us a great tip for a anti-aging supplement. Do you think there's a reason why most doctors don't prescribe it, or I've never heard of it before?
Dr. Sanda Kaufmann:There are… I like to think of today's medicine in three tiers. Tier one.
Mike (4):One
Dr. Sanda Kaufmann:Tier one is standard Western medicine, where we wait until you get a problem and then we try to fix it, right?
Mike (4):Brake repair
Dr. Sanda Kaufmann:We wait till you're diagnosed with high blood pressure, and we give you a drug. We wait until you have appendicitis, and we take it out. It's very reactive medicine. Tier two, there's something called functional medicine, and this is where they do more proactive testing and they promote a more healthy lifestyle, and it's extremely good for longevity. But tier three is the world in which I live. And tier three is longevity medicine, and this is the idea that we know why cells stop working over time, and we prophylactically fix things, right? So that we're not gonna wait for you to get a disease. We're going to reduce all relative risk of getting that disease, and it takes it's…
Mike (4):like cancer?
Dr. Sanda Kaufmann:Yeah, absolutely. We know why you get cancer, so if you can prophylax against it I can't tell you won't get cancer, but I can reduce relative risk of you getting cancer
Mike (4):Why do we get cancer?
Dr. Sanda Kaufmann:You get cancer because basically it's DNA failure. You're gonna love this. Yeah, you're gonna love this. Every cell every day has 10 to the 5th DNA errors. All right? That's a lot of zeros. 10 to the 5th, and if you don't fix them, your cells don't function. You have five DNA repair mechanisms that fail as you get older. They just do. You can up regulate them, but they do unfortunately. So when a cell has so much DNA damage, . It's one of three choices. It can either just disappear die, it's called apoptosis. It can become senescent, which is more, it's a source of inflammation, or it becomes a cancerous cell. So these number of cells that are cancerous increase over time, and your body has a normal way of getting rid of these. You have your immune system, you have natural killer cells and they float around your body and they eat up bad cells, so when you're young, you have damaged cells, but you can get rid of them, so it's not a problem. When you get older, you have more damaged cells and less of an ability to clear them out, so your chances of cancer go up, right? So what do we do? We boost all of those things to prevent or to lower relative risk
Mike (4):Okay. sense. a couple of other therapies have, been touted as being highly effective. Things like stem cell therapy or medicine with peptides. What's your opinion of those things?
Dr. Sanda Kaufmann:I mentioned earlier that we create longevity pyramids for people.… If you're gonna go into this, and if you're gonna invest in stem cells and peptides, you need to know the basics, and the basics are we optimize cells first, right? If your cell is a factory, and your factory is not functioning well, you can yell at it all you want, and it's not gonna do what you ask it to. So peptides are amino to your DNA and tell that cell to make something. But if your factory isn't working, it's not gonna do it, right? This is like asking a shoe factory to make Skittles. It just isn't going to do it. But if you fix your cells, then they will. So what I do for my patients is we optimize cells first and then peptides come into play because peptides are more like fixing individual problems. So let's say you're pretty well optimized, but you want a little bit of an immune system boost. That's a peptide. Or if you want a little extra muscle growth, that's a peptide. But peptides , by themselves are not fantastic for longevity. They're accessories. Stem cells are the same thing. Stem cells can fix a particular problem, but they don't reverse time. Exosomes, which are stem cell products, actually do a significantly better job of reversing time. I'm a huge proponent of exosomes.
Mike (4):What was that last thing you said that worked better than stem cells?
Dr. Sanda Kaufmann:Exosomes. So exo, E-X-O-S-O-M-E, exosome. So these are vesicles, little bubbles that essentially get released from cells, and they contain messages in the form of RNA and cytokines and chemokines and that sort of thing, growth hormone. And they cause tissues to regenerate and rejuvenate. So if you get these things from perifetal cells, meaning cells that were around baby tissues So we get them from the umbilical cord, we get them from the placenta of very healthy young ladies. And you can inject them into yourself. And the- there's the- the risk is extraordinarily low. Stem cell risk is pretty high. Exosome risk is quite low. So I inject this into my patients on a monthly to quarterly basis and people just do extraordinarily well
Mike (4):Now are any of these anti-aging procedures covered by traditional Medicare or advantage plans?
Dr. Sanda Kaufmann:I wish it were but no, it is not. I'm quite sorry. And some of them can be expensive. On the other hand, some of these things can be not expensive. I actually like to consider longevity medicine as its own internal insurance policy because by investing in yourself, you're lowering the risk of needing anything more expensive in the future
Mike (4):What kind of budget should someone set aside for, anti-aging?
Dr. Sanda Kaufmann:Oh my goodness, that's a really good question. It can be fairly cheap. It can be ungodly expensive. Exercising is fairly cheap, right? Getting your little butt to the gym, maybe you're paying for a pair of sneakers and, some enthusiasm and a cup of coffee. Other hand exosomes can be expensive. Some of the medications can be expensive. I- you could fall into the abyss of unbelievable cost
Mike (4):What kind of results have you had with your patients?
Dr. Sanda Kaufmann:Unbelievable results. Truly unbelievable. So we've fixed individual things like shoulder problems, knee problems thought processes, people's memory has gotten better, people's vision has gotten better, people's skin has gotten better. I've taken people who were sedentary potatoes and now they're, out climbing mountains with their grandkids. If people have the enthusiasm, the world is their oyster.
Mike (4):I- is there a doctor in The Villages area that, that does what you do?
Dr. Sanda Kaufmann:I guess I could be imported. My office is in Miami, but it's only a couple hours away.
Mike (4):It's a long five-hour drive.
Dr. Sanda Kaufmann:Find me enough patients and I'll drive up to The Villages.
Mike (4):We have 165,000 seniors here. And they advertise the place as a active senior and it is very active with, 3,500 clubs and activities. It keeps people's minds and bodies busy. From a medical perspective there's a lot of not the best medical care. find I have to go to Gainesville to see specialists. Now, in, in your practice how do you start with patients?
Dr. Sanda Kaufmann:We start just like a normal physician visit. And I do it in person and online 'cause I have a lot of international patients as well. And it starts just a regular, you're filling out forms, right? What is your medical history? How old are you? What's your diet? What is your exercise capacity? And just a brief example here, everyone talks about cardiovascular and muscular, and I like to put bone in there as well. Older ladies have issues with osteoporosis, and compressive exercises are extremely important. But anyway, so then we talk about medical issues. Do you have heart disease? Do you have high blood pressure? Do you have, such and such? What is your family history? If everyone in your family had diabetes, then that's clearly quite important. If everyone in your family had neurologic disease, clearly that's important. And then we, check standard labs and some specialized longevity labs and then we come up with protocols, and they're very personalized based on what an individual wants to do. None of this is mandatory. It's all rather elective. So how many pills does somebody wanna swallow? How deeply do they want to jump into this pool of longevity?
Mike (4):Yeah. I'm already swallowing way too many pills.
Dr. Sanda Kaufmann:I, we could compare and contrast. I take 72 supplements a day and 13 pharmaceuticals for diseases I don't have
Mike (4):How many pills a day do you take?
Dr. Sanda Kaufmann:I take 72 supplements and 13 pharmaceuticals
Mike (4):Oh, you dwarf me in the number of pills.
Dr. Sanda Kaufmann:But it's
Mike (4):you're 93 years old.
Dr. Sanda Kaufmann:I'm 104. Yes.
Mike (4):Okay. Okay. Yeah. You don't look it at all.
Dr. Sanda Kaufmann:Thank you.
Mike (4):Yeah, I'm only 102,
Dr. Sanda Kaufmann:see? It's amazing what longevity can do
Mike (4):And it, it does run in families and it
Dr. Sanda Kaufmann:There is a… Yes, there is absolutely a genetic component. But I will tell people that you can't rest your laurels on what your parents did. You're not living the life that your parents did and we're not living the life our grandparents did. They tended… The diets were different, their activity levels were different, their environmental inputs are different. So you may have good means, but you don't have the same culture necessarily unless you're living on a farm.
Mike (4):That's it
Dr. Sanda Kaufmann:So as a, example, like my father is 85 and he lives with his girlfriend who's 85, and they live on her horse farm, and my dad is the stable boy. Twice a day he's out there for hours feeding horses, mucking the stalls, carrying feed around, and just the physical activity and breathing healthy air and eating good food, you would think the man was 60. So it is truly amazing what you can do if you choose to do it.
Mike (4):Yeah. Not everyone wants to live on a horse farm. But…
Dr. Sanda Kaufmann:That's true. Small to be perfectly honest. I wouldn't want to either. However, he's in good shape.
Mike (4):That's the important thing. Now, in defining longevity medicine how would you… Will you put that in the, what you call the third group of medical? Okay. And what can people do to get more information or how do they contact you to maybe become a client of yours?
Dr. Sanda Kaufmann:So good questions. So I have two websites. The first one is more about the science behind all of this, and it's called the Kaufmann Protocol, and it talks s- it's science-y, but it's not… You don't need a PhD to understand it certainly. It's pretty common language, but it's science. And it talks about cellular aging, and it talks about my rating system so people have an idea of how to choose what agents. Sort of it's just informational. And so that's kaufmannprotocol.com. And then if people actually want to come see me as a physician, the website is kaufmannlongevity.com. And again, I see people in person, and I see people online, and we do exosome therapies and et cetera, et cetera
Mike (4):Okay. And are your books available on Amazon?
Dr. Sanda Kaufmann:Yep. The so what's interesting is , my work is incredibly scientific. It's, there's a little bit of entertaining fluff, but everything I talk about has a bazillion citations, so it is accurate. The pros of this are that you know that I'm not bullshitting anybody, and pardon my language. On the other hand, it takes forever to write these books. So the first book I think came out six or seven years ago. It took me another three or four to write book two. And what I've decided since is to release e-chapters because it just takes far too long to get these things written. So in addition to the two books that you mentioned, I just released something called Mastering the Mast Cell, and it is a, what I'm calling it's an e-treaty, so it's only online or electronic. It's on Amazon, and it talks about how we take care of mast cells because they're one of the contributors to aging. And I will be releasing other e-chapters going forward because they seem to be quite popular. Anyway, there's lots of
Mike (4):Are you planning on releasing the books as audiobooks?
Dr. Sanda Kaufmann:Not at the moment, no. The production costs are actually fairly high, so I haven't done it yet
Mike (4):Okay. Are there any questions that I failed to ask you that you'd like to tell our listeners about?
Dr. Sanda Kaufmann:I think that the one thing that I think is incredibly important… People always say if I do start supplements, where do I start?" And I like to mention the most generic place and it's a program that I call the PANACCEA.
Mike (4):Panacea
Dr. Sanda Kaufmann:And the reason it's called the PANACCEA, it's a panaccea, but not entirely, but the letters help define the PANACCEA. And this is a collection of five supplements that pretty much anyone can take over the age of 40 that will be absolutely beneficial. And the P stands for something called Pterostilbene. And you're gonna say, "Oh my goodness, I've never heard of this." It is an analog of resveratrol. There you go. It's a sirtuin 1 activator. And again, most people don't know what sirtuins are, but it's irrelevant. It's incredibly… It's… Sirtuins are on/off switches that help control homeostasis. So Pterostilbene is really important. So if you follow PANACCEA, P-A. A is astaxanthin. Astaxanthin comes from algae. It's a free radical scavenger. It reduces the risk of coronary disease, it reduces DNA damage, reduces sunburn if you're out in the sun, i.e. in Central Florida if you're playing golf. It helps vision. It's just the only thing that's counterintuitive to astaxanthin is if you have gout, so that's the only one thing. So P-A-N. N is your NAD precursor, and we talked about that. And then there's two Cs. The first C is curcumin, and curcumin is a fantastic natural anti-inflammatory. The problem with it is that it's not very bioavailable, meaning if you sh- take regular, generic grocery store curcumin, nothing's gonna happen. So you have to find a bottle that says bioavailable so it actually does something for you. And then the last one is another C, and it's carnosine, and this is a naturally occurring dipeptide, and it helps remove sugar from your body, and it also helps muscles repair better because you're reducing the acid load in exercising. So if you take those five things after the age of 40, you will only help yourself. And there it is,
Mike (4):And
Dr. Sanda Kaufmann:party hurts.
Mike (4):Where would our listeners find these five over-the-counter
Dr. Sanda Kaufmann:Amazon.
Mike (4):Say again?
Dr. Sanda Kaufmann:Amazon. Good? And if anyone wants link suggestions I think that they are on my website.
Mike (4):Good. for joining us today, Dr. Kaufman
Dr. Sanda Kaufmann:My pleasure. This has been lovely. Thank you
Mike (4):Great I wanna thank you for being on and I may wanna bring you back because you seem like you're a wealth of knowledge.
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