Dr. Vita Sonjak: Is Aging Inevitable?

We know movement matters - in a BIG way. But do we understand why? This episode features Dr. Vita Sonjak from Montreal, Canada, and her research focuses on why active adults differ so much from "typical" adults. We love taking an evidence-based focus to health, wellness and performance at Catalyst, and Dr. Sonjak provides the deep dive into what's behind high quality function and lifestyle well into our 80's!

Whether you're a health coach, wellness coach, performance coach or someone simply wanting to make the most of their life, you won't want to miss this interview with one of the top researchers in this area.

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Transcript

Speaker 1: 0:06

[inaudible].

Speaker 2: 0:06

Welcome to the latest episode of the catalyst health wellness and performance podcast. I'm your host, Dr. Bradford Cooper, and one of the goals of this podcast is to bring the evidence to the forefront. There are so many brilliant researchers out there with so many intriguing findings and yet we miss out on most of them because they aren't the dramatic headlines that provide clickbait or sell magazines. So we want to try to help bridge the gap between the research and you. In a practical way. You're the individual who's looking to try to improve your own health, wellness, your performance, or maybe that of your client. And we want to help do that. Today's guest is dr Vieta sanjak, a researcher from Montreal, Canada, and she has done some fascinating research on aging muscle and the difference between typical aging adults and masters athletes of the same age. It has such interesting research that helps drive home the point that you already understand movement matters, but sometimes it's nice to pull back the curtain on what's really happening beneath the surface and how does that apply to us in our daily lives. And we'll do that in this episode. For those of you considering pursuing your wellness coach certification now as the time now is literally the time, the requirements, and thus the cost of doing that. Pursuing your national board certification both increased significantly this fall. Our at home fast track for June is likely full at the time you're listening to this, but we do have one more chance in July that will give you the opportunity to meet the requirements for the MBH WC before the change. You can check out all the details or pull up our new ebook that provides all the steps, just walked right through it involved in that national certification@catalystcoachinginstitute.com or as always, email us anytime results@catalystcoachinginstitute.com. We'll set up some time and talk it through whenever you'd like. Now let's join the discussion with dr Vita sanjak on the latest episode of the catalyst health wellness and performance podcast.

Speaker 1: 2:13

[inaudible]

Speaker 3: 2:14

good morning, dr Sonic. Glad to have you join us today.

Speaker 4: 2:17

Well, good morning Brad. Uh, thanks for having me.

Speaker 3: 2:20

Well, this is gonna be fun. Your research looked at the difference between female inactive and octogenarian masters athletes. Talk us through, how'd you get here? What'd you end up looking at and what were some of the findings that that came about as a result?

Speaker 4: 2:36

Yeah, so when we looked at this very old population, so here I talk more about um, people that are 75 years of age or older. And at this age, right there is a high diversity between these individuals. So some individuals, um, have a greater deterioration of their muscle and are at a greater risk of falls. Mobility on pyramid, right there other are more resistant and they maintain higher function in advanced age. So for example, if we picture it like a group, a group of young soccer player, just to describe this variability between individuals. So this group of soccer players that are young, right? They are really similar in their functional capacity. They, they are, they have similar speed. They lift similar weight. But then if we follow this group throughout age, this small difference, for example, one is faster, 10 seconds and the other they come psych way bigger. So the physiological changes, the difference become more apprehend in appearance, more in in advanced age.

Speaker 3: 3:46

So, so it's almost like the divergence of the curves. You, you start at the same point and then one is, is you know, one, 2% difference per year and over time the difference between the two is just massive.

Speaker 4: 3:59

Exactly. Even though they start yes, at the same for example, um, activity level. So without age, everything changes. Wow. Wow. Yes.

Speaker 3: 4:09

And so then, Oh, I'm sorry, keep going, keep going. Okay.

Speaker 4: 4:11

Yeah. So yeah, w advanced age, then muscle undergoes structural changes and each month, so the muscle is composed of muscle fibers and with age the number of these fibers decreases as well as their size. So they shrink, which we also call atrophy. And when we look at the muscle in old age, there is also a high variability in, in this fiber. So we have three small fibers. We have very big hypertrophic fibers and fibers for different shapes and we don't see that in younger people. And then one of the factors actually that contributes to these changes and then also consequently can affect muscle strength. And physical performance is the, is the loss of motor neurons. So motor neurons are the neurons that are connected with the muscle and beat the it's contraction.

Speaker 3: 5:09

And is that just a, is that a choice, a lifestyle thing? Is it just inevitable? I mean, obviously part of it is inevitable. You're not going to be as fast at a hundred years old as you are at 30, no matter what you do. But it did your findings lead us down any paths of this is part of the contributing factors?

Speaker 4: 5:28

I would say that, um, also from my other studies, um, it, the muscle just undergoes these. Um, so the muscle undergoes these innovation reinnervation process while out of life. And what does that mean is that when we age, our muscle loses the connection with this neuron. But then it's again reconnected. And this happens throughout life and in very old age. This capacity for we connect of the neuron to the muscle is somehow impaired. So the muscle fiber just, it's there without telling it anything to contract and it slowly shrinks in size. Yeah. So this innovation, great nutrition happens throughout life. We can really prevent it.

Speaker 3: 6:16

And that's where you looked at the masters athlete. So you're looking at 80 year old sprinters and and other distances and you're saying, wait a minute, these people are such outliers. What's different? Am I getting that right?

Speaker 4: 6:30

That's correct. So I wanted to actually with my study to address the presence and the degree of this innovation reinnervation. So the connection between muscle and nerves in this low sedentary, I mean low functioning, sedentary elderly individuals and then see what is like contrast my findings with the high functioning masters athletes that exercise throughout their lives. So is there any difference in, in like fiber size or this reinnervation capacity just to see what enables them to function so well? Right.

Speaker 3: 7:05

My parents are 80 for example, they're relatively active. What can people be doing who are listening now at 40 50 60 to set up their eighties or, or what can people in their eighties be doing different to set up their nineties or their function throughout their eighties in any, did any tidbits come out of your research that guides us down that path?

Speaker 4: 7:25

Yeah. So my research didn't look, so with my study, I didn't book the specific really into that. I mean it's really hard to to to say it because there's a lot that we don't know in this area. Yeah. But what we do in a way no, is that, what would X or, so the number of these motor units right in the muscle that composed like the motor neuron and all the muscle that motor nerve innervates, the number of this motor units decreases with age. And it doesn't matter how active you are. What matters is the capacity of reinnervation. So the reconnecting of the myofibers and what we see with masters athletes is that they still have muscle atrophy. So my fiber atrophy, they still have presence of denervation, but they have a greater capacity to read their rate, those denervated fibers and prevent atrophy. So the shrinkage in their size. So exercise, I think it helps to, to keep this capacity for reinnervation, but we can not outrun the reduction in the number of the motor units.

Speaker 3: 8:37

Okay. So it's almost like we have a volume and an intensity. If we put it in different phraseology, the volume meaning the total number that's that's going down almost no matter what. Everybody has some genetic differences, but your number of them that will decrease. It doesn't matter what you're doing out there, but your intensity in a workout setting or the power that those pack, the ones that are left can stay at maybe not quite the same level. But that's where these masters athletes are excelling is they're keeping that, that power in spite of the decreasing number. Am I catching that right?

Speaker 4: 9:14

Yes, exactly. They are way back they, and that's also why they have retained their muscle mass. But we also need to understand here with masters athletes, right? They are exceptional like individuals, but they still, they cannot outrun aging, right? So they still show reduction in muscle mass strength and physical performance, but at the lower rate than um, like non master athlete individuals.

Speaker 3: 9:40

Right. And and significantly lower like right. When you're comparing these people that you studied to the typical population, it's, it's not a 5% difference. It's not a 20%. It's a, it's a massive difference, wouldn't you say?

Speaker 4: 9:55

Yes, they are. They, they, they, it's amazing. Yeah. They're at the, they're at the data. What we actually see because again, they have atrophy. They have all the signs of, of aging, but they retain their physical performance. So they are really exceptional. Yeah.

Speaker 3: 10:14

Yeah. One of our most popular podcasts is Joe Friel who wrote the book fast after 50 and he's, I think he's in his late seventies now, mid to late seventies. And, and people just love that one. Cause it's, it's the things that you're talking about and how do we, how do we limit that? How do we minimize that? So, uh, it's, it's awesome to have you on here kind of giving us a peek behind what's, what's actually happening behind the, the, the other side. What, what surprised you about what you found in your data? What, what, what were you going through and you went, well, huh? I didn't expect to see that.

Speaker 4: 10:48

Uh, yeah. So yeah, that's actually what we just talked about. So I was really surprised to the raid of a myofiber atrophy. And even the presence of veneration in master saturates. So we see atrophy at the micro celery level, but at the whole muscle level, they retain mass, right? They have significantly higher lean mass compared to the sedentary, uh, controls. And even as young sedentary individuals and they have way better physical performance. So from this, we actually, um, like suggest that they retain, um, veteran number of dose myofibers so there is still atrophy, but the number of fibers does not reduced, um, to the same degree as with the sedentary, um, individuals.

Speaker 3: 11:42

Oh, okay. So taking back what I said earlier when I was kind of summarizing, so they actually did keep some of their numbers total numbers up a little bit. They're still seeing a decrease over time, but, but their numbers were higher in addition to their mass being more,

Speaker 4: 11:57

um, myofibers yes. So with H, right, you have, you have, you can lose myofibers and the myofiber so date, like they, they, they complete the atrophy and die. And then you have other myofibers that that undergo again, atrophy. So they are smaller. So you have two components, you have myofiber atrophy and you have myofiber loss. So you know, the number of microfibers in the aging muscle is reduced. Um, and last year, sadly it's at the pairs that they retain. I mean they retained better the number of my fibers and elderly.

Speaker 3: 12:37

And did you get into what they were doing? Were there any qualitative pieces of this study looking at what is their daily routine? How long have they been lifting weights or doing interval training or any of those components? Or do you have some hypotheses around those from, from some of your expanded metal analysis, that kind of thing?

Speaker 4: 12:57

Um, so I um, I didn't look specifically into it but um, the group, so I only had around seven that the female masters afterwards and there was almost half, half, half endurance and half sprinters in that group. And um, most of them, they started exercising in the younger age. But there, I remember there was one that's started at the age of 50. Right. So that again tells us is it's really like when is the right time to exercise, to start exercising, to have then positive effects in advanced age. And um, and then again, other studies also show that even individuals that are 85 years of age and above, they still their muscles, their, uh, response to this exercise. So to mechanical loading, they still increase in muscle strength like compared for, um, and then, and this training enables them to improve their physical function, which I think is the most important thing in advanced age. Um, so a lot of changes might be actually utilize lifestyle that are negative, right. With agent. Right.

Speaker 3: 14:11

Okay. So everybody listening out there, you heard what she said, it doesn't matter what your current age is. Now today's the time folks. Let's get going with this. All right. So your study was specifically about octogenarians. If you were to hypothesize about the differences that are present between highly active and inactive individuals in middle age, you know, forties, fifties, sixties, what would you expect to see?

Speaker 4: 14:36

So yeah, it's really hard to comment that up, right? Because we don't know that much yet. And we also don't know if the improved reinnervation is related to genetic environment or like behavioral influences or a combination of these factors. But again, you don't need to be a masters athletes athlete to have like, um, benefits regarding exercise. Even like, um, recreational, um, studies show that even the recruiting recreational individuals have better this reinnervation capacity. But now again, completely hypothetical. Um, perhaps yeah, exercise in the middle age would enable better reinnervation capacity in the muscle. So, um, regular exercise does not preserve motor unit number as we said before, but may facilitate to successful reinnervation and starting for example, in their middle age may better prime that individual, um, for these changes that are more apparent in advanced age. So, you know, you would enter into old age, like more ready. Exactly. Yeah.

Speaker 3: 15:46

Okay, good. All right, so you've done a good job of starting to pull us into the practical side because that with, with this whole catalyst podcast, that's what we love here. What practical elements would you draw from the results in terms of what it means for the average listener with our lives, our activity levels, et cetera. At any age.

Speaker 4: 16:05

Yeah. Just like starting to move to exercise. And again, it's like we don't know how much exercise we need and for how long we need to exercise. But any kinds of movement, it's better than nothing, right? So we are all different, right? And we, we can start at different, um, States of exercising. So some individuals that just start even just standing from a chair or going for a walk. It's for someone exercise. But of course you need to build up on that. And I also saw for example, in, uh, in my young sedentary individuals that surprised me too is that their muscle under undergone like this, um, fiber type for modeling, which is again a sign of this like innervation reinnervation, which is similar to the old sedentary individuals. So they had similar fiber, um, um, remodeling. And this also suggests that muscle disuse in a younger age may, um, lead to, um, that so that these individuals are sedentary, may be more predisposed to ability to parent in advanced age. But then again, the muscle at the younger age is more, it's way more responsive to exercise. So it's never too late just to start like being active.

Speaker 3: 17:33

Hmm. Good, good. We hear that all the time, but now we get the science behind it. So the other things you're working on next, current studies that you're involved with, things that you're putting proposals in for where, where are you wanting to take this? What are we going to hear from you in two, three, five, seven years in terms of are you staying on this topic? Are you looking into some of those details and what people can be doing too?

Speaker 4: 17:55

Pop that up a little bit? Um, yeah, so, um, I'm still working on some of my data for my PhD. So what I'm looking in right now is to, uh, how resistance training in these sedentary elderly women, um, affect actually their muscle as well as this innovation we innovation process. And, um, what I found was that the, that the muscle that muscle fibers, they do, um, increase in size. So we see that resistance training has a positive effect and this elderly, they also improve their physical performance, um, like the overall lean mass. And they also would use some of their fatness. But then at the my cellular level, if you look more into this reinnervation capacity at the moment, I didn't meet and any significant changes, I did see an increase in decisive fibers that belong to different, that belong to a group. So a group is again, a sign of reinnervation process, but I didn't see an increased number of fibers within that group would exercise.

Speaker 3: 19:05

Okay. So w were these 80 year olds again, is it still in the 80, 90 age groups? It was interesting. Yeah. So these were people that were previously limited activity levels and you start them on a resistance training program and even in 80 year olds you're seeing improvements, not the numbers, but in terms of mass and function, which is frankly the one that they really care about. It is, is that correct?

Speaker 4: 19:30

That's correct. Exactly right. Yeah. And, and like maybe like even 12 weeks of resistant training, um, maybe that was not enough for that old muscle. Um, perhaps if we would have a longer intervention, maybe we would see also like in the reinnervation, uh, and um, really, you know, bigger effects. Um, because right, the muscle of very old individual is also, it has anabolic like insistence to exercise meaning that they need, uh, more of an exercise stimuli to get benefits compared to the young.

Speaker 3: 20:10

Okay. So let's run down that path cause that's an interesting idea. And again, I understand you may not have done specific research on this and if you want to throw some disclaimers in there about, we haven't said this exactly, but I'd just like to get your thoughts on it, kind of where you think it might be going or where things you'd like to look into. So you have this 80 year old moderate to limited activity levels and you start them to tell us first about what is this resistance training and they're obviously not doing dead lifts and tire pushes. What types of things did you have them doing or what were they involved with over that 12 weeks?

Speaker 4: 20:42

Okay. So I was so thirsty, I was not like really personally involved in the training because that was, um, that's w it is a huge project. So another colleague of mine, um, she was mainly into this exercise and nutritional intervention. But uh, from when we talk, so from what I know, they were training upper and lower body and they use small needles, uh, stationary equipment, you know, when you sit and

Speaker 3: 21:09

kind of pull with the arms. Exactly. Almost a bus, a seated bike with some arm movement type things.

Speaker 4: 21:15

Yeah. And even like, um, squats on the machine. Um, so they were like various um, um, these trends exercises and then they improved. I mean if they were able at the defined weight, I think it was like 60 or 80% of one repetition maximum. And once they were able to do the right 12 times, so, um, the repetition exactly in really good form, they increased the load.

Speaker 3: 21:47

Okay. So I like hearing this because we're not just talking about, cause a lot of times folks at work with older individuals are when they get started late they're like, well you know I should get on the exercise bike and actually ride for 20 minutes and then I'll be done. And you're saying in this study they were sitting there and they were doing the squat machine. They were completely safe, very protected setting, but they are doing the squat machine. They were doing the working the large muscle mass areas. Is that,

Speaker 4: 22:11

is that correct? That's correct. Yeah. Yeah. But again, right with very older people they're also afraid of falling and injuring. Right. So you need to assess it. What is their initial fitness level? Is it like safe to actually go directly to the machines? Should you first improve their balance and stability and make all the joints stronger and perhaps after that you, you know, you, you just build on that. Right. And these older they actually enjoy doing the exercises.

Speaker 3: 22:46

Love that. All right. Let's talk about just two questions left. Let's talk briefly about the masters athletes. What, as you were working with these masters athletes, I just want to get your opinion on this one. What makes them different? Because they're so different physiologically based on the choices and the decisions and the lifestyle. But did you, did you get anything out of their heads and why were they doing this and what drove on a daily basis? It's just kind of intriguing stuff. And since you interacted with the seven people for this, I'm just curious what you picked up that was encouraging to you.

Speaker 4: 23:19

Uh, yeah, so unfortunately I been really directly interact with them cause that was, yeah, I know, I know. I'm also a bit bummed about it because that's, this data was collected before I actually started my PhD. Right. But yeah, I mean they are exceptional and so perhaps, I mean they might even have optimal like genetic backgrounds focused attitude toward training, performing and also access to trainers. And I think, yeah, exercise is important but also like the nutrition that, um, like the food that you eat, it's also very important to get the benefits from the exercise that we do, especially in advanced age. Right? Because we know that older people, they don't consume enough, um, proteins or nutrients. Right? So when we start with the exercise, which, and we also need to optimize that, you know, to get the, the optimal benefit. Right.

Speaker 2: 24:18

And for you, you're not 81, what did this steady do to you and your perspective and what you're doing with your life and the plans you're making? Did, did it have an influence?

Speaker 4: 24:32

Um, I was, it just somehow concerned for me what I've been doing since a very young age. So I'm quite active that I, I haven't been competitively involved in, in swimming and even, um, after, um, like I ended my swim career, I still, you know, went to the gym. I did different classes, I did a bit of CrossFit, um, I bike. So it's, I dunno, it's just a way of life for me. It just to stay active and it's not even like feeling stronger. It also helps me to focus. It makes me happy. So I think besides like the whole exercise, it's, um, yes, it makes you fit, but there are also other, um, factors that exercise improves mood. And it pushes you also in a way to be more socialized, especially if you think of classes. Right.

Speaker 2: 25:29

Good. So last question, and this is taking your research hat off and just saying, from your experience, your research, your interaction, what you've read in the literature, any final words of wisdom you'd like to share with anyone that's trying to improve their health, their wellness, or their performance overall?

Speaker 4: 25:48

Yeah, so I would definitely say it's never too late to start exercising and make any changes, but yeah, it is important for people to take their hand, their health into their own hands because no one else will will do that for them. Right.

Speaker 2: 26:04

Perfect. Dr Sinai, really appreciate it. Thank you for joining us today.

Speaker 4: 26:09

Well, thank you for having me. It was a, it was really nice

Speaker 1: 26:18

[inaudible] in the

Speaker 2: 26:18

world of health, wellness and performance, it's common to just scratch the surface and ignore the details. That's why we were excited to have dr sanjak join us. Of course, we knew in quotes that activity and resistance training makes a difference, but do we know why now? We do. And it sounds like there's some intriguing research that we'll build on this right around the corner. Thank you for joining us. If you enjoy the podcast, share it with others. If you have two minutes to leave a positive review on iTunes, that goes so far to helping people find us. So really appreciate it. And if you enjoy this podcast, you might enjoy our new YouTube coaching channel, which you can literally find it. youtube.com/coaching channel. We just released a special video of one of the legends of health, wellness and performance to our subscribers there. So you might wanna check that out. Now it's time to go get better and help those around us do the same. And as we heard today, sometimes that is literally one step, one repetition at a time. This is Dr. Bradford Cooper signing off. Make it a great rest of your week and I'll speak with you soon on the next episode of the catalyst health wellness

Speaker 1: 27:32

[inaudible].