Cardiac Consult: A Cleveland Clinic Podcast for Healthcare Professionals
A Cleveland Clinic podcast exploring heart, vascular and thoracic topics of interest to healthcare providers: medical and surgical treatments, diagnostic testing, medical conditions, and research, technology and practice issues.
Cardiac Consult: A Cleveland Clinic Podcast for Healthcare Professionals
Novel siRNA, Lepodisiran, Reduces Lipoprotein(a)
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Cleveland Clinic Heart & Vascular Institute
In the first-in-human phase 1 trial of lepodisiran, a novel short-interfering RNA (siRNA) therapy, levels of lipoprotein(a) (Lp(a)) were reduced below the lowest limit of quantitation for nearly nine months. Steven Nissen, MD, summarizes these findings that were presented in a late-breaking science session at the American Heart Association Scientific Sessions 2023 and simultaneously published online in JAMA.