The DNA of Things with Dr. Jeremy Koenig

Episode 64: Rewriting Aging: Dr. Mark Tarnopolsky on Mitochondria, Muscle & Longevity

• Dr. Jeremy Koenig • Episode 64

In this episode of The DNA of Things, Dr. Jeremy Koenig sits down with legendary physician-scientist Dr. Mark Tarnopolsky to explore how exercise, nutrition, and genetics intersect to reshape the aging process. With over 500 peer-reviewed publications and decades of research in neurometabolic disorders, Dr. Tarnopolsky reveals groundbreaking insights into mitochondrial health, protein optimization, gene-environment interplay, and the future of therapeutics for aging and rare diseases.

This episode is a must-listen for anyone interested in the science of longevity, athletic performance, or functional health optimization.

🔑 Key Takeaways:

  • 🧬 Aging is not a sentence: Discover how cellular function can be reshaped through lifestyle.
  • 🏋️‍♂️ Muscle as medicine: Resistance and endurance training are critical for aging well and combating neuromuscular disorders.
  • 🥛 Protein timing & quality matter: Why whey, casein, and leucine-rich sources outperform trendy supplements.
  • ⚡ Exercise mimetics: Learn about Dr. Tarnopolsky’s breakthrough supplements like Muscle5 and Trim7 that simulate the metabolic effects of exercise.
  • đź§  From elite athletes to mitochondrial patients: How training principles apply across the human performance spectrum.
  • 🔬 Clinical-grade nutraceuticals: Why randomized, double-blind studies must back health claims—and how his startup is setting the gold standard.
  • 🔍 Genetics vs. epigenetics: Why knowing your genome is just the start—methylation, glycosylation, and environment matter too.
  • đź’Ą The future of healthspan: How brown fat, mitochondrial biogenesis, and smart protein dosing are changing the longevity game.

LINKS:

https://www.drjeremykoenig.com/
https://www.instagram.com/drjeremykoenig/
https://www.youtube.com/@drjeremykoenig


Here's the link for this week's episode: https://drjeremykoenig.substack.com/.