Episode 12: CHDI's Robert Pacifici on new treatments for Huntington's toasted with a Boulevardier

Andy and JC get the lowdown from Robert Pacifici, CSO of CHDI Foundation, on the latest in Huntington's treatments from the recent 20th CHDI Therapeutics Conference in Palm Springs, California. Robert has spearheaded efforts at CHDI for the past 22 years, driving forward preclinical drug discovery programs and corralling efforts to develop bioassays, clinical biomarkers, patient-staging systems, clinical and regulatory consortia to galvanize industry efforts in this devastating and fatal neurodegenerative disease. Just four years after the field suffered several reverses for ASO therapies in late-stage clinical development, there is renewed optimism that a new set of disease-modifying therapies are within reach.   

The Boulevardier 

INGREDIENTS: 

1 Oz bourbon (or rye) 

1 Oz sweet vermouth 

1 Oz Campari 

Ice cubes 

DIRECTIONS:

Stir over ice for 45 seconds, strain into a rocks glass over a large ice cube, and garnish with an orange peel.

Enjoy!

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Check out presentations given at the 20th CHDI Therapeutics Conference here

For a summary of the latest developments keep an eye out for a forthcoming news story at Nature Biotechnology

Paper's mentioned in the conversation:

Ai Yamamoto, José J Lucas & René Hen. Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease. Cell 101, p57-66 (2000).

The Mixer music “Pour Me Another” courtesy of Smooth Moves!