Basics to Brilliance: Haematology Podcast
Welcome to Basics to Brilliance, the podcast created to supplement & bolster your knowledge of Haematology.
Featuring a two way, non-didactic conversational-style Q&A between the SpR and SHO, this podcast will be your pocket companion no matter where you are.
We aim to cover:
- Malignant and non-malignant topics
- Science/lab detail
- UK guidelines, hallmark trials and how these translate into clinical practice
- Future research directions
- The whole syllabus for FRCPath part 1
All readily accessible and completely free of charge!
For every budding haematologist out there, we hope this podcast aids you in your endeavours and fills you with interest and excitement for the brilliant world of Haematology.
Warmest Regards,
Dr. Everden
Dr. Fasey
Dr. Jafri
Disclaimer: This podcast is intended as a revision aid and should not be used for the medical management of patients. Guidelines in the initial episodes span 2023/2024. We aim to update our content in accordance with the most recent available guidelines when possible.
This podcast is CPD accredited by the Royal College of Pathologists UK
Episodes
25 episodes
Lab Diagnostic Techniques for Haemoglobinpathies and Thalassemias (with Dr. Noemi Roy)
We are delighted to have Dr. Noémi Roy Consultant Haematologist at Oxford University Hospitals NHS Foundation Trust join us for this very special episode!
Red Cell Basics
Welcome to the Red Cell Series!Timestamps and notes to follow...
Dilemmas in Haemophilia
This is a discussion about possible factors and strategies to consider and should not be used as a guideline for clinical practice. Always discuss complicated cases with the attending H&T consultant.00:52 Intro01:30 Case 1: 41...
Acquired Haemophilia A
00:52 Intro and chuckles01:40 Case study: 75M, left calf swelling, put on DOAC, 24 hrs later haematoma and deep bleed on CT06:00 General informationElderly (>65), Mortality 8-40%Common presentations: GI and...
Haemophilia A in Pregnancy
00:52 Intro - very important topic02:00 Case Study: Haem/Obstetrics clinic, Family Hx Severe Haemophilia A, 12wks pregnant04:15 Clotting changes in pregnancyIncreased: FVII, FVIII, FX, VWF, FibrinogenDecreased...
Haemophilia A: Inhibitors
00:52 Intro02:10 DefinitionCommon: Alloantibody neutralizes FVIIIRare: causes increased clearance of FVIII1/3 of Severe Haemophilia A patientsMedian time 10-15 emergency dosesRF: Mutation t...
Haemophilia A: Management Basics
00:52 Intro02:35 Structure of Haemophilia A care05:10 Key aspects of management (On-demand vs prophylaxis)07:00 Prophylaxis: reduce death rates from ICH and reducing joint bleeds- Primary prophylaxis: before the 2nd ...
Haemophilia A: Diagnosis & Investigations
00:52 Intro02:00 What is Haemophilia A?03:00 Factor VIII, Pathogenesis of Haemophilia A07:10 Structure of Factor VIII (exam pearl)300kDHeavy (A1 A2, B) + Light Chain (A3, C1, C2) bound by a metal ions *...
Factor XIII (13), Fibrinolysis & Thrombolysis
01:45 Case: Neonate with repeated umblical bleeding. IC haemorrhage. Normal Factors (so far), Normal VW screen, Normal FBC and normal film.05:35 Factor XIII (13): function and presentations in deficiency 09:45 Testing, ...
Inhibitors in Haemostasis
00:52 Intro: definition and prompts04:25 Intro to Case 1: Haemophilia B, 3rd dose of BeneFix Anaphylaxis 06:03 Intro to Case 2: Severe Haemophilia A, joint bleed, non-responsive to emergency Factor VIII07:30 Initial sc...
Heparin & the Anti-Xa Assay
00:52 Intro (shoutuout to the BSH anticoagulant monitoring guidelines)02:15 Practical relevance of testing and monitoring anticoagulants 07:30 Heparin: The Basics 09:00 Unfractionated Heparin vs. Low Molecular Wei...
Thrombin Time & Fibrinogen Assays
00:54 Intro and table of contents1:48 Case 1: pre-op, prolonged PT and ++ prolonged APTT…thrombin time done03:44 Case 2: post-op, normal PT and prolonged APTT…thrombin time done04:46 Thrombin Time definition and ingredients...
Mixing Studies & Factor Assays
0:52 Intro and table of contents2:36 CASE 1- Infection, due surgery and a prolonged APTT ft. a refresher on APTT prolongation08:00 Mixing studies- definition and uses ft. Hari’s exam nugget17:00 Factor assays (1 stage...
Practical Haemostasis of the Clotting Screen
00:00 Intro04:25 Automated Methods of Measuring a Clot05:50 Scenario 1 & Pre-Analytical Variables11:50 HIL Index & Patient Factors15:55 Blood Tube Basics21:10 Nitty Gritties- What Happens When We Send ...
The Clotting Screen: Back to Basics
0:00 Intro2:45 What is Haemostasis?3:55 Stages of Haemostasis (summary)4:45 Primary Haemostasis 8:35 Secondary Haemostasis11:10 The Clotting Cascade12:20 Common + Extrinsic Pathway13:50 Intr...
Polycythemia Rubra Vera (PRV)
Polycythaemia- red cell #Erythrocytosis – in red cell massAbsolute Erythrocytosis- M: Hct >0.60 or >0.52 + RCM >25% of mean- F: Hct >0.56 or >0.48 + RCM >25% of meanAppa...
Secondary CNS Lymphoma
- Synchronous CNS and systemic lymphoma at initial presentation (treatment-naïve; TN-SCNSL)- CNS relapse without recurrent systemic lymphoma (relapsed isolated CNS lymphoma; RI-...
Primary CNS Lymphoma
CNS Lymphomas1% of all NHL3% of all Brain tumoursMost common subtype (90%) is DLBCL Clinical division:1. 1* CNS lymphoma, 2. 2* CNS lymphoma- TN-SCNSL- RI-SCNSL- RC-SCNSL
