#18 Pt1: Your Genes Run Your Perimenopause — The 3 Hormonal Archetypes

Episode description

Yulia Mintchin, Forbes 30 Under 30 entrepreneur and creator of FemGene, reveals why perimenopause is an epigenetic reprogramming event — not just a hormone dip — and how genetic testing can predict your symptoms and HRT response before a single prescription is written

Key topics discussed

•  Perimenopause as a communication breakdown between genes and hormones 
•  Why women were excluded from medical research and what that means today 
•  Hormone genomics and hormone genetics — a new medical category 
•  The three hormonal archetypes: Sensitive, Silent and Resilient 
•  The COMT gene variant and oestrogen clearance, affecting around 20% of the population 
•  Why HRT fails for 40% of women — and how FemGene aims to fix that 
•  Hormone metabolites vs hormone levels: the missing safety step 
•  Bioidentical vs synthetic oestrogen — the cherry Haribo analogy 
•  Endometriosis case study: progesterone and halted progression 
•  Oncology’s shifting stance on HRT and oestrogen during cancer treatment 
•  The WHI study and tamoxifen: historical context 

Timestamps

00:00 Why perimenopause may be about genetic response, not just hormone decline
01:00 Meet Yulia Mintchin and the FemGene thesis
03:10 Why perimenopause is medicine’s biggest blind spot
05:05 Hormone genomics and hormone genetics explained
14:15 The three hormonal archetypes: Sensitive, Silent and Resilient
23:05 Why doubling HRT doses can backfire
24:10 COMT, oestrogen clearance and personalisation
31:40 When women should start testing
33:20 Endometriosis case study: progesterone and progression
37:20 How archetypes change HRT decisions
41:05 What the FemGene process looks like
45:00 Bioidentical vs synthetic oestrogen
51:20 Red flags that HRT is being managed poorly
56:05 Oncology, HRT and shifting views on oestrogen
58:10 Outro and disclaimer

References and resources mentioned

•  FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/
  
  
•  The WHI (Women’s Health Initiative) study — landmark trial that shaped HRT policy 
•  Biohacking Eve episode with Jennifer Garrison, referenced as approximately Episode 1, on hormonal changes affecting 80% of body systems 
•  COMT gene and oestrogen metabolism — widely studied SNP; Yulia references the slow COMT variant 
•  Tamoxifen and breast cancer treatment — historical context discussed 

Guest social links

•  Instagram: https://www.instagram.com/yulia.mintchin/
•  LinkedIn: https://www.linkedin.com/in/yuliamintchin/
•  Will Be website: https://www.mywillbe.co.uk/

Insta/TikTok: @BiohackingEve
Website: www.BiohackingEve.com

Transcript

Judith Mueller 0:00

What if perimenopausal symptoms aren’t actually caused by declining hormones but by your genetic response to that decline? In this episode, Forbes 30 Under 30 entrepreneur and FemGene creator Yulia Mintchin reveals the three hormonal archetypes that determine how every woman will experience perimenopause Sensitive, Silent and Resilient and why the standard approach of doubling HRT doses when they don’t work can backfire spectacularly for roughly one in five women. We dig into the COMT gene, oestrogen metabolites, and why the 40% HRT abandonment rate is not a failure of hormones but a failure of personalisation. This one will change how you think about your hormones. Welcome back to Biohacking Eve, health Optimization for Women with Judith Miller, where we shine a light on everything that will help you reach your best self. As a woman, as unique and individual as then you can be live long and prosper my friend. Hello everyone. Welcome back to the show. Today I have Yulia Mintchin from Will Be With Me. So Yulia is a Forbes 30 under 30 tech entrepreneur, a repeat founder with a successful exit in IT, and she's now parenting fem tech innovation for precision hormone replacement therapy. So obviously perimenopause is a big focus. Welcome, Yulia.

Yulia 1:43

Thank you so much for the introduction and I'm happy to be today and share my vision and what we do at will be.

Judith Mueller 1:51

Fantastic. So, Yulia, when you say perimenopause is an epigenetic reprogramming event, what does that mean in practice? What does that mean in simple terms for say, a 40-year-old listener?

Yulia 2:05

Okay, so if we are talking directly to 40-year-old female listeners, they definitely know what perimenopause is. So I'll start from the beginning. Why we are talking about perimenopause in the first place is because perimenopause is the biggest blind spot in modern medicine because women were not included in medical research until 30 years ago because of our bodies being too variable, because of our hormones and our cycles. And this has led women to being dismissed, unsupported during this critical transition. And been working in this perimenopause space for the past three years. And when we started, we've realized that wow, this is a massive problem. Women losing their jobs. One in five women leave workforce and never return leading to personal financial burdens. Not like even corporations now are having allocating budgets to help women to go through perimenopause, not to lose key talent. So this is the impact that perimenopause has and when we've been trying different solutions and when we started will be, we realized that anything we do, any woman we treat, we need to start from genetic testing because your unique biology should be the single overriding factor in the way you are treated. And one thing led to another and when we realized that actually perimenopause is not just a declining levels of hormones, it's actually a communication problem between genes and hormones. And that was a breakthrough understanding, which we started to dive deep on. And that has led us to creating two scientific frameworks. One big scientific category which is called hormone genomics and hormone genetics. How you are genetically wired to produce hormones in the first place, and how you are responding genetically when your hormones begin to decline. And what we've realized that, perimenopause is an epigenetic reprogramming event that determines the way a woman is going to age for decades to come. It's when our biology is giving us a chance to rewrite our aging health trajectory. And what we have been missing from perimenopause care is that hormones are powerful epigenetic regulators. And to be honest, we haven't discovered anything new. All we did, we looked through all the published research, which is out there the glass sites peer reviewed literature, and we put it all together into a simple tool for perimenopause called Fem Gene that helps women predict what symptoms they're going to experience when they, begin this journey of hormonal decline and how they will respond to hormone replacement therapy before it is prescribed. Because problem right now is that when a woman goes to the doctor, it usually takes them two to four years to find the right dose of hormones to get that perimenopausal symptom relief. There are over 120 different symptoms associated with perimenopause, and women are reporting six to seven symptoms at the same time, at in intensity felt of eight or more. This is this is a massive silent health crisis, which is happening to 51% of the world population, and currently there are 1 billion women worldwide in perimenopause struggling because we don't have any solutions for those women.

Judith Mueller 5:46

And what I found really interesting, so to the listeners I'd like to refer you back to an episode with Jennifer Garrison, I think it was episode one, where she talks about, look, these hormonal changes that we're seeing, they're actually affecting 80% of the systems that we have in our body. So brain bones, metabolism, immune system, mood, skin, et cetera. Right. And what I find also very interesting is that perimenopause so far has been a guessing game in the sense that you are in a period where everything is changing already, right? In the sense that your hormones are fluctuating. It's basically second puberty in many ways. And you're trying to titrate, you've got different treatment options. These can all be done at different dosages, different delivery methods as well. So you're trying to try trait something. For a moving goalpost. So while your hormones are changing, you're always trying to catch up and it just doesn't really work. So I think that's where the genetic testing upfront, where it's like, this is how you're likely to respond, is actually very, very interesting. So tell us about the different types of responders that you're.

Yulia 6:54

So first of all, I will comment on something that you said. You are absolutely right that when hormonal decline occurs, it affects all of the systems in the body because every single cell in female body has estrogen receptors and aging and hormonal decline, they go hand in hand, is just the fundamental fact of life. And when hormones begin to shift and decline our genes are getting completely different instructions to what they used to be getting. Because remember, hormones are powerful epigenetic regulators. They keep our genes on, and when hormones are not there, those genes go off. And this is not very like proper scientific language, but this is just to get to that school of thought. And this is exactly the reason why a lot of women during perimenopause are saying, I feel like my body has been hijacked. Obviously, your genes are getting. Very different instructions to what they used to be getting when your hormones were at optimal levels. And when we're talking about perimenopausal symptom management, we actually need to start testing our genes first, because turns out perimenopausal symptoms, they're not hormonal. They are your genetic response to hormonal decline. When we, analyzed a lot of different receptor sensitivity genes, detox pathways, how you're genetically wide for inflammation response how you're genetically wire to detox hormones and are you more of a pro inflammatory troian metabolites or anti-inflammatories TRO metabolites. And then we put it all together into functional categories for each hormone. And we then linked those genetics to symptoms and from symptoms to HRT dosages and formulation decisions. And then we saw something remarkable patterns, repeatable, predictable patterns that are biologically explainable. And that's led us to this breakthrough that there are three types of responses to the same hormonal decline rooted in genetics. It's basically your genetic sensitivity to hormonal decline. And we call them hormonal archetypes. And hormonal archetypes is just the headline message for women to understand what is going on with them. To give women identity so they stop blaming themselves. This is just when you know that this is how you're wired, you just accept it. It's fem gene heals identity in the first place. It heals those years of dismissal. This is just in your head. This is stress, this is everything. So this is what powerful. But if we dive deeper into the scientific part, under each hormonal archetype there is like lots of data points that form a hormonal phenotype which we assess and that led us to creating our proprietary clinical model that helps doctors to personalize HRT safely and effectively without needing PhD in genetics and without two to four years of trial and error. Because it's not just women that are frustrated, doctors are also frustrated when the same patient comes back again and they can't help. It devastates not just women. It devastates doctors. And.

Judith Mueller 10:19

You say you also had three different archetypes. You've got a sensitive silent and the more resilient, responsive archetypes. Talk through that.

Yulia 10:26

Yeah.

Judith Mueller 10:27

Yeah.

Yulia 10:28

So there are three hormonal archetypes. Which is how women are wire to hormonal decline, for example the sensitive woman she's the one that feels, any changes in her hormones massively. She has receptor sensitivity genes. She has a slow detox pathways hormones are not clearing and that causes a buildup and the throws of the whole system of balance, and therefore she's feeling so unwell when hormones begin to decline. Then there is silent hormonal archetype, for example. She doesn't feel the common symptoms of perimenopause, but we need to be really focusing on preventative strategies for that archetype because for one woman, while she doesn't feel any symptoms and she doesn't seek for help she for one woman, low estrogen means. Fast track to osteoporosis because she has weak genes for bone health while for the other one low estrogen means fast track to insulin resistance and weight gain. And those two women require completely different approaches. Or if we're talking about resilient women, the same but resilient women they tolerate hormone replacement therapy really well. Those are women that usually we see once a quarter, those women are more interested in preventative strategies. But for somebody with a sensitive hormonal archetype a very common response that we hear is whenever we hear something like, I've tried hormones, but they didn't work for me, we definitely know it's either the sensitive woman or the silent woman because, it's just not possible. Your hormones worked for you your entire life. It's just the way they were replaced. That's the problem that didn't work. So for the sensitive woman, it's this overreaction and for the silent woman is that she tries, but she doesn't feel any difference because her detox pathways are too slow. She's too fast. She's clearing her hormones too fast and or she has on the not that sensitive hormone sensitivity receptors. So it's just it gives women language to explain what's going on with them.

Judith Mueller 12:40

And I find it so interesting. So if you're saying two women have similar hormonal panels, so similar Estrada, progesterone, et cetera, in bloods, but they've got completely different experiences, and this actually explains why you want to look at the epigenetic side of things.

Yulia 12:56

Of course of course, because as a when we imagine genes and then we imagine hormones turning genes on and on, whenever you have like weak genes, those are genes the most that are affected.

Judith Mueller 13:11

So can you give us for example, very concrete examples. So some say someone's got a detox pathway variant that changes how estrogen is cleared and what does that mean for hot flushes, for mood, for breast risk, et cetera.

Yulia 13:25

Okay, so for example a woman goes to her gp. She's struggling with hot flashes and her GP gives her estrogen dose. She goes, tries it, but it doesn't work for her. She comes back to the same gp and the GP says, okay, let's double the dose. All right. She goes back home, she starts taking double the dose of estrogen, but it's still not working. She stops taking it without knowing that she probably has. Slow calm gene, which means she's very slow with processing estrogen, and therefore she is just getting the buildup of estrogen rather than estrogen working for her body and converting estrogen into anti-inflammatory estrogen metabolites. So that would be like a very solid example when we don't do genetic testing, when we don't do hormone metabolites testing. We just don't know that. And what I find ridiculous that there are so many private gps, I'm not even talking about N Hs, that just don't do any sort of testing before prescribing hormone replacement therapy because, hormones don't work. When we misunderstand what perimenopause is, when we understand that it's communication problem between genes and hormones, that's when we can use those precision tools to create those personalized, preventative protocols for women, because it's not just about symptom relief. Hormonal decline accelerates biological aging by eight to nine years. And therefore it accelerates all of the risks for age associated diseases. And like another problem that we're using seek care tools for healthcare transition. And when we don't implement personalized strategies. During this healthcare transition, women are pushed into sick care with entirely preventable conditions such as osteoporosis insulin metabolic dysfunction, heart disease and all of those completely preventable. And there is a massive evidence base that it's all preventable. Estrogen is used for osteoporosis as a drug now.

Judith Mueller 15:35

Let's stick with this example actually, because the com gene, about 20% of global populations actually has a major variant in the sense that there's a major dysfunction from that variant. So you're saying that doesn't clear estrogen, so when you stick more estrogen on it, when you double the dose, that doesn't work. How would you act in this case? So obviously that's, you know, medical disclaimer that's on a prescription at this stage, but it's just to understand if this affects 20% of people, of the population, how would you actually go around that?

Yulia 16:07

So first of all, there are supplements that can help us speed up detox pathways at biochemical levels. And we don't need pharma drugs for that. It is just those natural supplements, giving the body raw materials to perform the way they are supposed to. And comp is very dependent on methylation as well. And again, disclaimer, I am an entrepreneur not a scientist, so I might use terminology incorrectly, but there is a strong link between your methylation and your calm gene. They are the another thing that we would need to do first is optimize your methylation and then optimize your calm gene.

Judith Mueller 16:47

Fantastic. The other thing, we're only saying things that affect a large share of the population. Let's flip the coin a little bit and I appreciate this is a little bit off topic, but looking at andropause, so testosterone decline in men. So we would think that for men it's a lot simpler because we are just looking at one hormone. I'm guessing. What does that process look like? How would you test for that? Or is it just a level of you just need blood tests? You don't need to look at the epigenetics of it.

Yulia 17:16

So We have opened an entirely new global medical category called female longevity. Unfortunately, I am not an expert on male health but I know that a male body is not as dependent on hormonal balance as female body for female body. Hormones literally govern our health. They govern everything from our heartbeat to our breath to our energy levels, our confidence in everything. I know it's very different for men but not the right person to talk about Anthrop Pause.

Judith Mueller 17:52

Fair enough. I will find the right person to talk about that. Speaking of, what are the data limitations when we're looking at these things, how do we avoid over interpreting genetic?

Yulia 18:04

All so that's a good question. And while we absolutely agree that genetics is only 20% of the whole picture and the rest is on the well, epigenetics it's important to note that still they show us your baseline tendencies. And still lifestyle is so important. That's why there is this whole shift of how we approach health in a preventative manner. That we start with genetics and then we look into your lifestyle. So while genetics is very important just to know your tendencies, just to know your patterns, it's very important to keep testing other things with functional tests, to see how your body actually processing things and how it's behaving in real time. And we are not solely focusing on genetics, but the way we build genetic test is very different to other genetic tests on the market. We own our IP lies in the interpretation layer. Of the genetics. We don't use this reductionist approach that if you have this s and p, therefore you have this. We built functional categories for each area that we are interested in, and that allows us to paint the whole picture for the tendency. But yes we are not relying completely on genetics. It's very important to do functional testing to see how your body works in real time. And what's important to say while we are talking about perimenopause and the reason why we are in a perimenopause space in the first place is because we are actually just. up the mess of the whole industry because if we were to test hormone metabolites and genetics in women that are 20 years old, 30 years old, we would know their genetic vulnerabilities and we would know how to approach perimenopause in preventative ways. And we would be able not just to escape age associated diseases, but also escape all of the symptoms that come with perimenopause. So it's baseline. You need to know your baseline. Your unique biology should be the single overriding factor. The way you are treated. And how we don't interpret things is by building hormonal archetypes and turning complex genetics into personal stories.

Judith Mueller 20:22

This is interesting when you say we need to start early in an ideal world, so perimenopause is somewhere between 37 and 52. Statistically, when would you actually start testing and what would you start testing when? So it just doesn't make sense, you know, for a 20 old woman to get a test of some sort, to have a baseline? Or is this something that you say, once I'm feeling changes, you should get into.

Yulia 20:49

Absolutely. I would say post puberty. The cycle is stable when we know what's going on, the the earlier data you have it's your benchmark point, right? And, at the end of the day, hormonal imbalance is hormonal imbalance and younger girls that are struggling with endometriosis, PCOS and other all sorts of conditions. At the end of the day, they are hormonal imbalances. Those eye, unless it's already has been physically manifested into stage four endometriosis. is a hormonal imbalance in the first place. And I will tell you a case study. While we specialize in perimenopause, we naturally get girls with endometriosis because they struggle. So we had a client she is 32 years old doesn't have children has stage four endometriosis. And she's treated by NHS. And NHS said, okay, it's time to remove everything because your endometriosis is progressing. And she was hopeless. And she met us at the health optimization summit two years ago. And all we did, we introduced progesterone pill in the second part of the cycle and it. The progression slowed down. She went back to her NHS endometriosis specialist. They compared the scans. There was no progression of endometriosis after one year of taking progesterone pill in the second part of her cycle. And I'm talking about bioidentical hormones only.

Judith Mueller 22:24

And why would that be? So TEUs light data, why or what is the effect on progesterone in endometriosis in particular? Why is it missing and what is the, how does it work?

Yulia 22:33

It is about hormonal balance. Endometriosis is estrogen dominant state. You're probably genetically white for producing a lot of estrogen and less progesterone. Or you have low receptor sensitivity genes for progesterone and therefore the progesterone you're producing is just not landing like it could be many things, and yeah, it is just the school of thought about approaching hormonal imbalances and female health issues.

Judith Mueller 23:02

And coming back to the archetype. So we said we've got a sensitive, we've got a silent and the resilient slash response of archetype. How stable are these? So for example, if someone tests at 42 and 48, could that archetype change or is it more like a base operating system?

Yulia 23:18

If we're talking about archetypes, it's genetics, genetics doesn't change but your lifestyle can push you into feeling like you probably not that type of an archetype, right? So yeah, genetics doesn't change, so your archetype doesn't change.

Judith Mueller 23:35

Okay. And sticking with the archetypes in practice, what is the biggest decision that comes out of, say, once you've determined a woman's archetype? In terms of dose, in terms of root of HRT in terms of add-ons like luciens and lifestyle focus.

Yulia 23:53

How does it okay. It, how it cuts time to relief, first of all, because we know that for the sensitive woman we first need to optimize things before putting on her own HRT or for the silent woman. We need to awaken those receptors so she finally feels the, benefits of hormone replacement therapy. But the problem is the doctors right now, they don't have a map to navigate all these different responses and hormonal archetypes. They give them this map, and with each hormonal archetype, there comes a protocol which doctors can implement. And we have massive interest from longevity clinics, longevity hospital, not just longevity hospitals. Actually, proper hospitals are interested in this. Fem gene is not just about HRT, for example. Another application of fem gene is for women that are going through surgical menopause. When hormones disappear overnight, again, it predicts symptoms. It guides recovery protocols of women that are going through breast cancer treatment. And on hormone blockers, the same thing. It supports other, pathways that are important when women are suppressed of those hormones.

Judith Mueller 25:05

Okay, and let's talk about fem gene in particular. So, you know, 43-year-old listener in London, for example, hears about fem gene and goes through the test. So what happens at every stage?

Yulia 25:18

Okay. We are a telemedicine service. So she gets it from our website. Then we are in contact with her. She receive her test kits to her home. We guide her how to take Femin. We guide her how to take hormone metabolite tests. So hormone metabolites test, who needs to be taken day 19 to 21 of the cycles. So we then arrange a courier pickup for those tests. We send it to the lab, a woman waits. Then once the results are back the report is generated. We book a session with her with our Dr. Vanessa. Who is a chief scientist behind this fem tech innovation. And Dr. Vanessa, she translates fem gene into personal story. She moves the thinking of what is wrong with me, to, okay, this is how I'm wired, so what do I need to do about it?

Judith Mueller 26:11

And I've had a chat with Vanessa. Very insightful. So we'll do a separate episode on that as well to dig more into into that. So about interpreting genetics without catastrophizing. So many women hear about genes and they immediately worry about breast cancer, dementia, et cetera. How do you frame that genetic risk without putting people into fear and freeze?

Yulia 26:31

You're talking about women are scared about finding out if they have a predisposition to some age associated diseases.

Judith Mueller 26:40

That, and obviously there was this whole misunderstanding around HRT because there was a flawed studies and I think the eighties that basically shaped all of HRT thinking for decades to come.

Yulia 26:51

story and I will start with it. So whenever somebody says that hormone replacement therapy, estrogen in particular, causes cancer the first thing that we should ask is, what estrogen are you talking about? Are you talking about, those estrogens that are in our environment, those fake estrogens. Are you talking about estrogen that was used in the study from a horse's urine? What type of estrogen are you talking about? Or are we talking about? Bioidentical estrogen? That our body naturally produces exactly the same molecule that when women are pregnant those levels rise massively. And women are not the demographic that has problems with breast cancer. Statistics clearly show that the demographic that struggles with age associated diseases it's a hormone deficient state. So it's again, like you just need to critically think about it and ask questions and the fear will be gone because there are things like the sky's a blue the trees are green and you can't deny it.

Judith Mueller 27:58

I hear you so.

Yulia 28:00

like you can't blame chemical la cherry Haribos for the impact that a synthetic hormone. I'm just trying to do a parallel between cherry Haribos with cherry flavor and synthetic estrogen. They cause them massive imbalances in the body, but cherries they don't, and the bioidentical estrogen also doesn't.

Judith Mueller 28:24

I think that's a very good example, Ashley. And this brings me up to the next question in terms of how to have an intelligent discussion with your doctor around these topics, because as we mentioned, there's still a lot of misconception out there. I think even a lot of doctors are still scared of HRT.

Yulia 28:40

So this is a massive problem because of women. Were not included in medical research. We're not talking about a small medical oversight. We are talking a massive scientific gap. And doctors are not trained in HRT. They're not trained in I'm not even gonna say anything more than that because the fundamental understanding of what perimenopause is what we're bringing to the table. So there is absolutely no point of discussing it. Nobody understand what it is. Until now, we are going to show the world what it is.

Judith Mueller 29:17

I like the spirit. And you to broaden that impact in the sense of, for example, if there's a listener that doesn't yet have access to fem gene for, you know, whatever might be different part of the world, et cetera, what are. Three questions that she can ask her GP or gynecologist to instantly raise the level of conversation from, you know, it is all in your head to, let's actually think about this.

Yulia 29:43

That's a very good question, and it's also very hard one because while I think that all women should have access to hormones, it's biological, right? But are still at the stage of innovation and it'll take time until it's adopted by, healthcare services, let's say. So when you are asking me that, do you mean private gps or you mean like NHS doctors?

Judith Mueller 30:14

I think anywhere, I think whenever women are, are being. For whatever reason, gaslit by the doctor. How can they, obviously, other than changing doctor, potentially, but that's hard, right?

Yulia 30:24

just find the doctor. Welcome to will be just read our content. We share lots of content. We are commercializing the science. Like we're working on democratizing access to hormones because it's a biological right from all of the longevity modalities. Maintaining optimal levels of hormones is the most powerful evidence-based fountain of use. And every woman should have access to it, but only if it's done in personalized way. And this is what we're working towards. We're working towards a pharmacogenomic platform that will allow clinicians to get the right dose for every woman. But yes, it'll take time. Just find, just the advice is to find the doctors that are about genetics when they're talking about perimenopause and menopause that are advocating for hormone replacement therapy because it's the embodiment of preventative medicine. When we are young beautiful and energetic, we have optimal levels of hormones. And then aging begins when hormones begin to decline.

Judith Mueller 31:28

Indeed. So I'm gonna play devil's advocates here from two viewpoints. We'll start with the first one. For a woman who's already on HRT, what is a red flag that her current HRT is managed or is used for symptom suppression rather than a long-term longevity plan?

Yulia 31:47

Not testing hormone metabolites because the fear around hormone cause cancer is not because hormone levels cause cancer. Hormones don't cause cancer is your genetic predisposition to pro-inflammatory estrogen metabolites. For example, estrogen metabolites going through the wrong pathways. This one things begin to go towards a bad scenario. So monitoring your hormone metabolites while on HRT is essential. It's crucial. You need to do twice a year. HRT is a commitment, same as health span is, its commitment like we are obviously talking to biohackers and, like you can't drink alcohol when you are on HRT, because it also affects your estrogen metabolites like its commitment. Longevity is commitment.

Judith Mueller 32:41

And I think a lot of people are still looking for the silver bullet. At least that's what, that's what I'm seeing a lot. Let's look at it from the other point of view. So we said for someone who's on HRT but is not used well, what about the other category of a woman who says, look, I'm open to HRT, but she's been told it's not for you. Without any further explanation, what data points or tests are often missing from that decision? Obviously we've talked about the genetic testing.

Yulia 33:10

So again, brings me back. I tried hormones, but they didn't work for me. You can't have hormones. Why not? Your hormones worked for you your whole life. Why can you not have hormones? Even oncology is shifting already and women that are going through breast cancer, they are still given estrogen while they are doing treatments. There is this school of thought is changing dramatically right now. It's changing fast. And like traditional medicine such as oncology, which I like hugely huge respect, right? But they already understand the systemic importance of maintaining hormone levels. And interestingly, before WHI study and before Tamoxifen went on the market, breast cancer was treated by high doses of estrogen.

Judith Mueller 34:05

And what happened to that,

Yulia 34:07

And then I don't know. I don't want to speculate,

Judith Mueller 34:10

the profitable drug came on the market. Okay, let's leave it at that.

34:19

Thank you for joining me on this transformative journey. Your presence in this community is truly valued. Now, you may not realize it, but your words hold in men's power. They have the ability to reach others. You may benefit greatly from the wisdom shared here. If you found value in what you had, I kindly ask you to take a moment to subscribe to by Hacking Eve. Leave a glow and review on your preferred podcast platform and share by Hacking Eve with your friends and family. Your support helps spread the message of health optimization for women far and white. Lastly, I want to express my gratitude to you for investing in yourself. We're prioritizing your wellbeing, new service, and inspiration to others. I'm eagerly looking forward to bringing you many more exciting episodes, and thank you for being a vital part of our community. Live long and prosper, my friend. The Biohacking Eve Health Optimization for Women Podcast is for general informational purposes only, and does not constitute the practice of medicine, nursing, or other professional healthcare services. Including the given of medical advice and no doctor patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be substituted for professional medical advice, diagnosis, or treatment. Users should not disregard or delay obtaining medical advice for any medical condition they may have and should seek the assistance of the healthcare professionals for any such conditions. In addition, the information on this podcast does not constitute investment or financial advice.