#20 Pt2: How the Pill Disrupts the Microbiome Long-Term

In Part 2, Ronny Szelinsky explains the mechanism behind oestrogen-driven microbiome collapse at menopause — and what can be done about it. He introduces the estrobolome, details the research behind Get Happy's Happy Fem probiotic formula, and explains why oral probiotics colonise the gynecological tract as effectively as vaginal delivery. This is the translational bridge between the science of Part 1 and the practical interventions of Part 3.

Key Topics

• How oestrogen controls the thickness of the vaginal and endometrial tissue, and what happens when it drops
• Why UTIs become suddenly frequent after menopause — the biological mechanism
• Vaginal dryness and pain during sex: the mucosal layer explained
• The estrobolome: the bacterial community around the ovaries and its proposed role in oestrogen production
• The contraceptive pill and its long-term impact on microbiome colonisation after stopping
• Happy Fem: how the product was developed, the research methodology, and the fertility clinic partnerships
• Why oral probiotics achieve equivalent vaginal colonisation to vaginal administration — three pathways
• Lactobacillus CA-15: what the published research shows
• Who should take vaginal probiotics and under what circumstances
• When to pause: during pregnancy, and why
• Dosing: six-month courses for specific goals; ongoing daily use for post-menopausal women

Timestamps

• [Part 2 start] — Hormone-microbiome axis, oestrogen and tissue thickness
• [~05:00 into part] — Why UTIs spike at menopause
• [~10:00] — The estrobolome: ovarian bacteria and oestrogen production
• [~17:00] — Happy Fem: product development and research methodology
• [~22:00] — Oral vs vaginal administration — clinical study results
• [~27:00] — Lactobacillus CA-15: what it does
• [~30:00] — Who should take it; when to pause; dosing logic

References and Resources

• Happy Fem product: www.get-happy.com
• Lactobacillus CA-15

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Transcript

Judith Mueller (2) 0:00

Here's something that surprises almost everyone: an oral probiotic capsule colonises the vaginal and uterine microbiome just as effectively as a vaginally administered product. Same colonisation, after thirty days, regardless of the route. Which raises the question if bacteria you swallow end up in your reproductive tract, what else is talking to it? In Part 2, Ronny Szelinsky explains the feedback loop between your oestrogen levels and your gynecological bacteria including a concept called the estrobolome, which suggests the microbial community around your ovaries may actually be influencing how much oestrogen you produce. We get into the product his team built from scratch: six specific strains, selected after sequencing the microbiomes of fertile and infertile women side by side. And we end somewhere unexpected with what happens to a woman's microbiome with every baby she has. It only goes in one direction. And the mechanism behind it involves what the baby receives in the first seconds of life.

1:11

Welcome back to Biohacking Eve, health Optimization for Women with Judith Miller, where we shine a light on everything that will help you reach your best self. As a woman, as unique and individual as then you can be live long and prosper my friend.

Judith Mueller (2) 1:35

​In Part 1 of this conversation with Ronny Szelinsky, founder of Get Happy, we talked about what the gynecological microbiome actually is, why Lactobacillus dominance not diversity is the mark of a healthy vaginal and uterine environment, and how a dysbiotic microbiome can silently undermine fertility even when there are no symptoms. We covered the discovery that the uterus is not sterile, and how chronic inflammation in the reproductive tract attacks sperm and prevents embryo implantation. Now in Part 2, we go deeper into the hormone-microbiome relationship, explore the emerging concept of the estrobolome, and get into the science behind Get Happy's six-strain oral probiotic formula.

Judith Mueller 2:23

you mentioned something really interesting around how the hormones are impacting the microbiome and vice versa. How does that work in practice in layman's terms?

Ronny Szelinsky 2:33

Yes. So this is like also a topic this that is so not like 100% clear. I can just say what we know so far. So what we know is that we have like, mainly connection to estradiol and estrogen. Which seems to be the main important hormone when we're talking about gynecological and reproductive microbiome. So what we see is especially in the aging process, for example, every listener already knows. So we have a massive and really rapid and fast decline in the estrogen levels with entering the menopause. And now from science, we know that it leads to different things like getting, and this is like a biological really bad situation because all the protection that you had over let's say 40, 50 years so you will lose this protective situation not over 30 years. You will lose it within a really, really short period. And this is a massive problem. So nearly from year one to another, you start to have a higher risk for nearly everything like bone health will decline, your cardiovascular health will decline, et cetera. They're like, nearly everything is somehow affected and. The situation that we see connected to the microbial system is that this tissue use especially the uteral and the vaginal tissue use where, which is like the basic living ground for the bacteria, they are connected in their thickness to the estrogen levels and the lower the estrogen levels are, so when they decline the thickness will shrink more and more and more. And this is like going really fast. This is why, for example women that are in menopause from nearly day one to another, they will experience having UTIs like all the time. They're like thousands and thousands of women that have this problem and they never had that before, from one year to another, they start to get UTI problems and bladder infections, like all the time and this is because this layer is getting thinner and the thinner the layer is you also have a let's say suboptimal situation where we're talking about this whole how the viscosity of it. Of this of the, cervix that is on it., And because of the thickness is getting thinner thinner, and also the cervix is getting thinner. So the layer that is actually should be thick and soft. It's getting thinner and also harder that's also why women in their or especially after immuno poot experience vaginal dryness a lot and experience pain while having sexual intercourse because this layer is actually getting smaller and it's like it's losing the softness. And this is a problem that is not just affecting the viscosity, for example. It's also affecting the microbiome because the bacteria that are living on it now, they're losing their living ground. The thing is, what we see is that bacteria are the other driver for this layer. For this tissue because they produce postbiotics that are able to have impact on the growth of this tissue also on the thickness. And when we see that we have two situations right now that are affecting it the basic logic that we are doing research on right now is will we somehow be able to have a non-hormonal way? Not talking about HRT. Hormonal replacement therapy, because a lot of people don't want it, even if we have new signs on it yet still a lot of people are afraid of it and they don't want any like like outer impact on their hormones could there be another way to keep up. The system by bringing the right bacteria in because typically you will lose them. You'll lose the bacteria when the estrogen levels are declining because they lose their living crowd. But if you bring in the right bacteria and they're producing the right postbiotics and have impact on the system the hormonal situation will not impact the system that much that it would do with not bringing in the right bacteria and we keep it up over this impact factor, which is way, way more easy, enjoyable. There are no side effects. It's like a totally convenient, easygoing way of keeping the system in a good and more healthy state than having like this hormonal impact and that is the basic mechanism behind it, and that is so interesting.

Judith Mueller 6:45

At the same time as we said, once people go into menopause, obviously there's so many other factors as cardiovascular health, there's cognitive

Ronny Szelinsky 6:52

Yes.

Judith Mueller 6:52

cetera, that is impacted by hormones. So

Ronny Szelinsky 6:54

Mm-hmm.

Judith Mueller 6:55

talking people out of HRT, I figured something should be looked at in

Ronny Szelinsky 6:58

Now

Judith Mueller 6:59

there was one term that keeps cropping up. The estro. What is that?

Ronny Szelinsky 7:03

The estrobolome is something which is really new. This is a term that was like just existing for a really short, short time and I can just say what basically the theory is because we don't have a final solution, or actually we don't have a clue how it's going in detail. We just know that it seems to be there.

Judith Mueller 7:28

Says that, when it says, we dunno what's going on, let's find out.

Ronny Szelinsky 7:32

yeah, then it would be just guessing. But I can tell you what the basic theory is. The s for bottom it seems to be situation that like from the ra producing system in like the ovaries. There we see that the ovaries also they have like a specific microbiome which is connected to the uterus and the vaginal microbiome like that. It's comparable species. Huge crossover and they call this specific surrounding bacteria and system. They call it the estrobolome because this seems to impact the production of estrogen and we are not talking about like the whole, what is the ovary and everything, but we know actually that there are different systems in the human body where hormones are produced. And from the logical perspective, it absolutely makes sense that if you have a system that is hormonal producing, and this is surrounded by microbes, the microbes will actually be the main driver for how healthy the system is, how healthy the tissue is, how healthy the cervix is. And it will have a healthy health impact. And if impact on the system that is producing hormones is given by bacteria, we know that bad bacteria also can shift the system into a more negative state. So that's what we see when people, for example, take our bacteria. And they take our what we developed. They start to have more regular cycles because the hormonal situation, it's impacted we don't know in every detail how this is going. And it's also a bit different from person to person because also the microbiomes can be a bit different and the situation will be a bit different from woman to woman. But what we know is that when we keep a stable lacto, basili dominated situation up. It also will have a positive impact on the hormonal situation of a woman especially on the, that's what I said. Also in the question before the umra situation, which is the main like biological, hand in hand giver. For the microbiome in the gynecological tract, and this is basically what the COV of the Astro Ball is where we see also that it seems to be somehow modulated also by the gut because people also talk about the, the gut microbiome when we're talking about the astro ball and there we see that there is also a crossover between the gynecological tract and the gut microbiome and this is it is somehow going hand in hand. And this is what I, in the early beginning of our talk I just said there are postbiotics and this postbiotics, they seem to be signal givers for each other. It seems like trains are producing post biotic products that are giving growth signals to specific other strains even if the strain is a different species, it can give growth factors to the other strain. And this is where we see that. Maybe that's the theory from the biological side. There are bacteria that have to be in the body because they're not just important for their own function and their own system. They're also important because they're actually the voices like shouting out to the other systems that are also colonized by bacteria and the growth of the right bacteria over there. And this is like this like thing going hand in hand in the estro ball in between the gut and the gynecological system.

Judith Mueller 10:52

Let's turn to the various solutions that you're building, 'cause I know you've got a couple of pillars that you're looking at.

Ronny Szelinsky 10:59

What we have for the first solution that we are talking about is we were thinking about fertility because as I said though, we were seeing this huge decline in birth rates. And we thought, okay maybe when we talk about vaginal health, like there are, so many companies right now globally that are talking about the vaginal microbiome. So we are not the only ones. We are, but we are one of the few that are talking about fertility. And fertility is something that is connected to the vaginal health and also the endometrial health. The most people that are talking about the vaginal microbiome, because I think that a lot of people that are talking about it, they don't have a clue what it actually is. So what they tell you is that it's about vaginal and intimate health. It's about like like having a normal odor having just normal discharge like nothing that is irregular. And this is important for sure when you're talking about, okay, you have like unusual discharge it's maybe also a different visco of thickness it's also like having a strange smell or something you should think about a microbiome for sure, because you have a high chance of someone having an infection. Maybe the infection is really going on and you are the 50% of women that are feeling and also experiencing really the bacteria vaginosis, for example. But there other 50%, they will have no symptoms at all they don't have like unusual discharge itching or something. And this is an important factor for basic vaginal and intimate health so this is actually affecting mainly the front vaginal tract. This is important when we're seeing the lower and the deeper vaginal tract and like let's say the whole gynecologic tract with the endometrium then we are thinking about fertility and that was our topic that's where we saw okay actually it should also affect the fertility somehow in a way and that's where we're starting to think about, okay, how can we solve a problem that a lot of women experience don't have a solution on? And also a lot of women experience like having problems to get pregnant or planning to get pregnant over a longer period. And it's not working out that well that have no clue that they have a problem there and no symptoms and nothing I think if you, if you have like a UTI all the time, you know, that it is something you should fix for getting pregnant, that it will affect you in a specific way. Or if you really experience a bad bacteria vaginosis, you know that. But the majority have no symptoms at all. There's just an underlying situation that is leading to inflammation, et cetera and what we did with the product is we took women from fertility clinics that we're experiencing having problems to get pregnant. And we took women that had like. Huge number of babies. That are really, really, really fertile. And also people that were just regularly having one, two, two children. So regular birth. Right? And we compared to each other. We also did our sequencing. We looked on which kind of strains can we find? And then we looked on what are the characters of the strains that we mainly found in there and we, for example, looked on antioxidation. We looked on inflammation. We looked on what is it doing with the material? Is the material that is colonized really thick and healthy? Or is it more thin layered? What are the differences? And we had different measurements, and based on that we saw that there are specific strains that always had a positive situation. We also we also compared strengths to each other with putting bad bacteria into the system and just saw, just seeing how different strains are pushing away the bad bacteria. So, how good is the protecting mechanism of the bacteria against the pathogens where we know and this is something we knew from the science that was going before that are affecting fertility in a bad way and that's where we in the end, found a specific strain set of six strains that were the most effective and protecting and also inflammation lowering characteristics. For the strains that we were able to found there were thousands of more strains. We have to say microbiome is not always that easy because you cannot. Bring in thousands of strains there are two ways you could do it. One way would be to take a woman that is really fertile and to like take the material and bring the material into a woman that has a problem to get pregnant. This is what another company I think in Denmark or Sweden Denmark, I think was doing in a few years ago having a huge huge like response in the science network because of the study. But this was end of one study, we have to say. This was like. One trial where had actually worked that a woman that was having problems to conceive was able to conceive after getting the vaginal tissue material from a really fertile woman in. This is good because it's showing Okay. It seems to work. We know that it's also done in the gut that we have stool transplants in this way. It was like a vaginal transplant in our way we think that this is nothing that is mass convenient. Because we have so many people struggling with their fertility like it's nearly one third of all women right now, when we look on the couples, one third of all couples will experience infertility or fertility issues. You will not be possible to have that many women giving their vaginal material and transplanting it into other women. That's the first problem. The second problem is it will be massively expensive. You will pay like 10,000 of, of euros or dollars for that. In our way we did what is called a single strain approach we build the product strain by strain. By strain. In the end, we had the specific cluster of where we said, okay, this is the cluster that is the most effective that we have right now that we, we saw in our research. And this is something where we say, okay, this is also convenient. This is something where we can roll it out into the market and it's also affordable because this is also really important for us, we want to bring solutions that are effective but also affordable and accessible, and nothing that is like behind blocked clinic doors for 10,000 of dollars for the top, top, top 1% where we see, okay, but what is with the R 29% of the people that have a problem? What should they do? So we were like going into this direction. So that's where we brought out the first product called Happy Fem in March, 2025. So this is still new but it, took a while to do our research we are really big fans of understanding the topic and having really the final solution, protecting it and then bringing it out and not just doing it halfway somehow. Yeah, that's the story basically of it.

Judith Mueller 17:25

The interesting one there is for happy femme. My understanding it's oral delivery rather than vaginal administration. Why?

Ronny Szelinsky 17:32

Yeah. So this is a really good question and this was also one of the main hypothesis we had in the early beginning of the research. Is it possible to actually thrive and impact the gynecological ecosystem without using the vaginal way of bringing it in which is typically done with lactic acid, for example. Yeah. If you have a really acute bacterial vaginosis or infection and you go to your pharmacy, typically you will find a lot of products that are administered vaginal, and it will have a direct impact that's what the theory actually is. Just saying one thing for all the women that are thinking lactic acid is the final solution, it is not. Lactic acid is actually something that has like a short time impact of the pH situation. It will drive the pH situation in a specific direction, which is more Yeah good benefit, let's say, because pH is important for the species that are like needing the specific pH score to be able to survive. But this is a really short term thing. It's like just for a few days changing pH situation, if you're not doing anything, it will go back into the bad situation again. It will only work if you also bring in the right bacteria. Like without the right bacteria that are actually the producers of the lactic acid, you won't have a long-term holistic solution for it. You would just have like a short symptom impact, maybe. That's it. That's first of all, so second of all

Judith Mueller 19:01

It'll be products like lacto, for example, which I think are lactobacillus. Is this something

Ronny Szelinsky 19:05

yeah.

Judith Mueller 19:06

can, I wouldn't say self treat. Obviously if you do have an issue, go see a doctor. But if this is something for example, if you don't have an issue and you're not trying to get pregnant, you're not trying to solve anything at that particular point in time

Ronny Szelinsky 19:18

Mm-hmm.

Judith Mueller 19:18

a lactobacillus product on a regular basis.

Ronny Szelinsky 19:22

Yes, for sure. That's also what our users are doing. So maybe just to come to the question with the oral administration. So that's where we also did like where we have the clinical studies too. So we have two clinical studies that were actually comparing vaginal administration and oral administration. And that's where we saw it because we just tried it to be honest. We just, it was just like trying to see how it's working. Actually everyone thought that it's failing totally. So that it's not, not coming into the gynecological system, but we saw in the end that the colonization between the vaginal input and oral intake in the anti colonization, after 30 days of taking it, it was exactly the same. There was no difference at all and the thing is that we have three different ways for the oral way. First of all there's like a ary situation where we see that over the urinary system. We also have like a specific washout and where we see okay, that this is like connected to the reproductive and gynecological system and bacteria will also cross over into the tissues of the retinal and the whole gynecological tract. Second thing is like a smear infection, what it would be called in a bad way. But there's also a crossover from the anal to the vaginal tract. And this crossover also is happening for bacteria that are like like helpful for the vaginal system. Lact and the third thing is the whole posto situation. And that's what I already described. So if you have like bringing in signal givers from the right bacteria, they also give like signals to growth of the species that are existent, but maybe in a in a way which they're not. Many. Just a few and they're having the right signals for growing. And populating the system in the reproductive tract and the gynecological tract, these are the three basic mechanisms, and that's where we decided, okay. This was not a scientific situation in the end because we saw, okay, both is working out quite well. This was a convenience situation because we thought, okay, is that we did like re request and everything, like, and majority, like 95% said, okay, if I can do like oral intake, that would be way easier than like a vaginal administration for sure. And then that's where we actually decided to go into this oral direction and we see that other players in the pharmaceutical market, for example, after we did they all, you see that behind the closed curtains Also, other players are working on that. There's also like a pharmaceutical product in Germany, for example. This is like doing it exactly in the same way. Using a bit different species. I don't know. I don't see the research behind that. I was not able to see that. Maybe it's hidden research or something that it's not like for, for everyone., But they do it in the same administration way, which is good to see. It's also working out for them. This is the, yeah,

Judith Mueller 22:03

yeah.

Ronny Szelinsky 22:04

question.

Judith Mueller 22:04

Which strains are you using? If you can share?

Ronny Szelinsky 22:07

I can share one because basically the whole mix is protected. So I can tell you one strain, which is called lactobacillus ca 15. Because typically you have you have like different strains that are called in a specific number. There you have, like you will find hundreds or thousands of diff of strains. And you will see that it's the same species and the same type. It's lactobacillus. Then you say, okay, this is lactobacillus Crispus, for example and then you see, okay. But there are also 10 different lactobacillus Crispus in there but sequencing shows that it's like another genetic sequence. It's not the same. It's not really, it's not the same strain, it's the same species, but it's a different strain. And there we typically just put numbers behind it. And one of the most effective strains that also public research is there for this strain. So it's like was publicated, so it's called ca 15. And the ca 15 alone, just the strain alone, was able to populate the gynecological microbiome in a way where we had less inflammation, we had better tissues, thicker tissues, and, and we saw it was pushing away. Just the strain alone was pushing away bad pathogens like streptococcus or Gardnerella Vaginalis one example.

Judith Mueller 23:26

Interesting. And is there anyone that this is not for or when should someone pause it?

Ronny Szelinsky 23:31

You also had a question. If you can just take it as a regular basic, so Yes, you can do so. I see I, I have a specific view on nutraceuticals because we are like a nutraceutical. Because also it's taken like with, on this oral way. No, not a vaginal pharmaceutical product. If you are taking nutraceuticals or micronutrients or whatever I'm a big fan of doing it with a specific. Purpose, let's say. Not just taking everything just somehow. You should do it when you see, okay, you would benefit from it right now that's why I say okay for people that they experience that, for example, they have like vaginal health problems. Or people that have pain while having sexual intercourse, have a low libido, have irregular or painful cycles. People that have endometriosis has like like microbiome and endometriosis. There are studies out there right now and scientists that open up the theory that endometriosis is not just happening somehow, that endometriosis is the end state of a bad microbiome situation, which is resulting in growth, unwanted growth actually, of tissue material in the gynecological or the gut tract. This is like a big theory that we have in science right now. And I'm quite I think my theory is that it is like that and in the next five years we will have the final reports and the final studies on that, which are showing that yeah, that's a microbiome thing that's not just somehow happening. So this endometriosis if you are planning to get pregnant or have problems to get pregnant. This is also important. And that's basically, it also if you if you conceived, if you are like, your pregnancy is done and you have the birth of the baby, so we know that after every birth, the microbiome will get in a bad state. And we know that women that's also what we see. Women that had more babies, basically with every baby, their microbiome started to get less diverse it's not, not saying that it's getting bad. But it's losing the diversity, which is important. The diversity is an important factor for microbiome and it's getting less and less diverse, which, and in the end can lead to results, like having more problems with vaginal health for example. And this all are things where you should think about taking it on a regular basis. You don't need to take it if you don't experience anything of that. If you have like a regular cycle you have like a good hormonal situation in health. You don't have vaginal problems, why should you take it death? So there's no makes no sense you also should stop taking it when you are in your pregnancy. That's also what we say. Not because it's bad so there's no risk yet. So there are studies on that. There's no risk factor for taking it in the pregnancy. But what we see is that pregnancies are so different. And we have a pregnancy, also a pregnancy microbiome the microbiome over the pregnancy changes and there is what we tend from our company philosophy, we tend to always bring the body in a natural situation. So if we were able to bring the body into situation where the fertility was high and the conception was working, so then we have the right basic situation, and actually we want to let the body develop in a free way in the way where it's actually natural for this specific person in the pregnancy. And that's where we say, okay, there's no negative impact by taking it. So we don't have to be in fear that there's something bad happening that's not at all. But we want to say, okay, why should you bring in bacteria right now in a situation where your microbiome is like uniquely changing, that's just happening in pregnancy it's like a unique change of the microbiome why should we somehow affect that? So when before beforehand everything was fine with our with our solution, yeah. And fertility was good. Why should we do that? This is like the, the two situations where I would say you don't need it or you should not take it. For everything else also. Massively important entering the menopause and after menopause, I would actually, suggest every woman that is like entering menopause or after menopause, I would suggest every woman to support by taking a bacteria for the gynecological tract. It will have a huge upside for sure.

Judith Mueller 27:58

And you would take this as a course while say, why are you going for a menopause? Because there's all these changes. Is that something that post menopause, you should be taking, you know, on a regular basis or you take a course, I dunno, once or twice a year? How would you do that?

Ronny Szelinsky 28:12

what we saw is after taking it for one month like just talking about what we saw with our solution after one month taking it, the microbiome was stable in this. State what we actually build up with, with the solution for one month taking it one month, it will be stable for one month after that. So basically you could do it every two months that's if you really want to do it in a cost effective way also you have a stable situation after taking it 30 years. 30 days it will stay for 30 days. Then you should take it again, what we always say is if you have a situation that is really like just a specific time perspective, for example getting pregnant or for example, you have issues with your vaginal health, take it as a core of over six months. That's what we typically suggest. If you say yeah, I want to do it on a regular basis, for example women that are in or like in the menopause or after menopause there is no cycling anymore in this situation. It's not like fluctuating and changing like it's before there. I would say yeah, bring in the right bacteria all the time. Make it as new basis for everyday basis because it's, it's just important. There are also other examples where I would say, yeah, this is something women in an after menopause should definitely consume like an add-on to their normal nutrition when we're talking about micronutrients, for example. Yeah.

Judith Mueller 29:36

Are there any idea why the diversity is changing as women have more babies?

Ronny Szelinsky 29:44

this is where we are talking about the regular birth. So we're talking about like a regular birth where the baby is actually going through the birth channel. We have something that is called seeding. Seeding is something where, and this is important for babies.. So babies that were seeded, which actually means they're going through the cervix on the tissue through the birth tract and the whole cervix is actually colonized by billions of bacteria. And this bacteria will colonize the baby it will colonize the skin. The baby will have like also like an open mouth while getting born. It also will enter into the mouth it will actually, this is the basic, the basic set that a baby is getting as a bacterial colonization. This is like the regular, normal birth set and it's also entering into the mouth and also into the guts there it's important for every microbiome not just the skin. So what we see is that babies that are born through like on a natural way and that experience, a seeding that was a science was showing in the last years. They have a lower rate of for example, allergies lower inflammation also they have somehow, we don't know why, but they have lower obesity rate. They're, it seems like they're whole system is working more efficient their whole gut system is also working more efficient. And this is like having a huge impact on everything that is connected to your immune system. They have, like, for example, allergy allergies is one example. And they have a better immune system and this is made by dose bacteria which is not made. If you have like an like, yeah. Or artificial birth, let's say if you're not, like a baby's not born on a regular wave for birth channel, you miss out the seeding and then you have to be lucky if you have a good doctor. They're doing the seeding manual. They are taking the material of the retinal tract and they're actually smearing it on the neck of the baby and the skin, and also putting it into the mouth this is good. This is a good doctor then. Unfortunately the most doctors don't do that. Typically this is something that should be done always. But back to the question, why is it getting less diverse it seems like with this is by the way, just happening by regular births if you are like, having like a birth through the birth channel this mechanism seems to somehow disrupt the microbiome of the woman. In a specific way where it's not building up that diverse after it. We don't know why. The theory is that there are specific strains that are given to the baby and strains that it seems like the body things they don't are needed anymore and this is why diversity is lowering than so maybe it's just a theory but maybe those strains are strains that are not just important for the women's or the female health, or maybe not important at all, but important for the baby then. And this is where the diversity, if you take a woman after the pregnancy will get lower within the pregnancy so if you're getting pregnant again, this is what I mean with this unique pregnancy microbiome the diversity will start to rise again so it will start to get higher. And there are strains from like in the pregnancy that you don't have before. It seems like those strains are important for the baby. And this is how it's going, but with every birth, the diversity is going lower and lower. And that's why I say also with the solution from taking the vaginal transplant from one movement to another, it doesn't automatically mean that if you take the the vaginal transplant from a woman that had whatever, five babies, for example, it's the best thing you can do actually you should take the material from a woman that had five babies and it's pregnant six times, that, that would make more sense in my opinion. But basically if you take it after the fifth or sixth baby, the divers will be way, way, way, way, way lower and that's why I say this end of one trial, I don't know if it, that's, if it's really something that can be compared to every woman and every situation or if it was maybe lucky somehow. But that as it as it is, yeah..

Judith Mueller (2) 33:50

So we've covered the hormone connection, the product, and just now what happens to a woman's microbiome with every birth, and what her baby receives in the first seconds of life. But there's a piece of this story we haven't reached yet. His team is building a diagnostic tool that could read the state of your uterine microbiome from a simple vaginal swab no biopsy, no anaesthetic, no disruption to the tissue you're trying to protect. We're also getting into what he thinks will be clinically normal at your gynaecologist within a decade that doesn't exist yet. And there's an emerging theory about one of the most under-diagnosed conditions in women's health that may reframe it completely. All of that in Part 3. Thank you for joining me on this transformative journey. Your presence in this community is truly valued. Now, you may not realize it, but your words hold in men's power. They have the ability to reach others. You may benefit greatly from the wisdom shared here. If you found value in what you had, I kindly ask you to take a moment to subscribe to by Hacking Eve. Leave a glow and review on your preferred podcast platform and share by Hacking Eve with your friends and family. Your support helps spread the message of health optimization for women far and white. Lastly, I want to express my gratitude to you for investing in yourself. We're prioritizing your wellbeing, new service, and inspiration to others. I'm eagerly looking forward to bringing you many more exciting episodes, and thank you for being a vital part of our community. Live long and prosper, my friend. The Biohacking Eve Health Optimization for Women Podcast is for general informational purposes only, and does not constitute the practice of medicine, nursing, or other professional healthcare services. Including the given of medical advice and no doctor patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be substituted for professional medical advice, diagnosis, or treatment. Users should not disregard or delay obtaining medical advice for any medical condition they may have and should seek the assistance of the healthcare professionals for any such conditions. In addition, the information on this podcast does not constitute investment or financial advice.