Bremelanotide, also known as PT-141, is one of the most misunderstood sexual health medications available today, and it has one of the strangest origin stories in modern medicine. It was originally studied as a tanning drug, but researchers not...

Hedonism II is a resort in Jamaica that’s split between two worlds: half clothing-optional, half nude-mandatory. It’s a place intentionally designed for adults who want freedom, curiosity, and connection without judgment.Yes, people can...

Addyi was marketed as a breakthrough. But is one additional satisfying sexual experience per month, on average, worth abstaining from alcohol and accepting the risk of meaningful side effects? That question sits at the center of a drug that gen...

www.shamelesscare.com is your go to for all your prescription sexual health needs. Use coupon code podcast for $15 off today. No subscriptions - ever! Chlamydia has been around far longer tha...

Everyone knows that oral sex can cause cancer, but what kind? And is there a test for it? Trigger warning: CancerRobert got a bit emotional at the beginning of this one. Cancer is a scary word. HPV is one of the...

She had sex in a car, got an STI, and filed an auto insurance claim. And unbelievably, it worked.In this episode, we unpack one of the strangest legal cases in recent memory. A woman contracts an STI after having sex in a parked car, fi...

You are not the man your grandfather was. And that is not an insult. It is data.Over the past several decades, sperm counts have fallen dramatically and average testosterone levels in men have declined across generations. This episode l...

Vaginal lubrication. You love it. You want it. But do you actually understand it?In this episode, we break down what getting wet really means and why it is one of the most misunderstood parts of sex. We talk about how lubrication actual...

Sex is supposed to be fun — but for a lot of people, it comes with some unsexy side effects.In this episode, we talk honestly about bacterial vaginosis (BV), urinary tract infections (UTIs), and yeast infections — why they’re common, wh...

Before Viagra, erectile dysfunction was not treated with a discreet pill and a glass of water. It was treated with injections straight into the penis, vacuum pumps that looked like medical torture devices, hormone experiments, surgery, psychoth...

Christmas is supposed to be wholesome. Family friendly. Safe.Historically, that could not be further from the truth.Long before Christmas trees, carols, and Santa Claus, winter celebrations were loud, chaotic, and openly sexual. Anc...

For decades, HIV was a diagnosis defined by fear, stigma, and loss. In this episode, we trace the true history of HIV from its earliest recognition through the AIDS crisis and into the modern era of treatment and prevention. We explore how scie...

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Are you trying to keep a secret?In this episode, we break down what actually happens to your telehealth visits, prescriptions, and test results after you click “submit.” What gets documented. What gets shared. What might quietly show up ...

Everyone says herpes screening tests aren’t “accurate”… but is that actually true?In this week’s podcast, we break it all down: specificity, sensitivity, positive predictive value, IgG versus IgM — everything you could possibly want to know...

In today’s episode, we may have our best Dirty Joke of the Week ever.Oh — and we’re also answering six sexy questions with real science.What exactly is pre-ejaculate?How likely is pregnancy after a vasectomy?How fast do sperm di...

You become a part of everyone you have sex with and everyone you have sex with becomes a part of you. That is not poetry. That is biology. There are more bacterial cells in your body than human cells and more viral particles than both of those ...

In this episode Robert and Anna take you inside the world of CLIA certified labs, the invisible backbone of every STI test in the United States. If you have ever wondered how a lab earns its certification, who oversees it, what standards they m...

This episode is your invitation to the side of Thanksgiving that no teacher ever mentioned. Robert and Anna pull back the curtain on the Puritans and reveal a world that was a whole lot less pure than the myths. These were people who preached r...

Today we break down the pharmacology that every man should know. Sildenafil and tadalafil belong to the same class of medications, but they behave very differently. We cover the evolutionary path from early cardiovascular research to the discov...

The FDA just removed the long standing warning on female hormone replacement therapy. For more than twenty years women were told that HRT carried major dangers, but the science has changed and the original fear was based on misinterpreted data....

Most people think the Tuskegee Syphilis Study was a secret government experiment uncovered by a brave whistleblower. It wasn’t. For forty years, the U.S. Public Health Service openly studied hundreds of Black men in Alabama who had syphilis—wit...

You’ve feared a virus that causes sores on your skin ever since you started having sex — but it probably wasn’t this one.Today, we’re talking about Molluscum Contagiosum — which is contagious, in case the name didn’t give it away.

Robert and Anna get shameless about oxytocin — the hormone that makes you cum, cuddle, and occasionally catch feelings you didn’t order. It’s nature’s love potion, but now science is selling it by the spray bottle. Does synthetic oxytocin actua...

In 1983, British physiologist Dr. Giles Brindley walked onto a medical conference stage, dropped his pants, and revealed a full erection — all in the name of science. That legendary (and unbelievably awkward) moment became the birth of modern i...