Contributors

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Host

Dr Sarah Marzi

Having graduated with degrees in mathematics and psychology from the University of Freiburg, Dr Sarah Marzi completed her PhD in complex disease epigenetics with Prof Jonathan Mill at King’s College London and worked as a postdoctoral researcher with Prof Vardhman Rakyan at Queen Mary University of London. At the end of 2019, she established an independent research group as an Edmond and Lily Safra Research Fellow, joining the UK DRI at Imperial. The Marzi lab combines experimental genomic and epigenomic techniques with innovative statistical and computational analyses to understand gene regulatory mechanisms contributing to the earliest stages of neurodegenerative disease. Dr Marzi became a UK DRI Emerging Leader at UK DRI at Imperial in 2021, and a Group Leader at the UK DRI at King's in 2023.  

https://www.ukdri.ac.uk/team/sarah-marzi
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Host

Dr Sarah Mizielinska

Dr Sarah Mizielinska joined the UK DRI at King's to establish her first group in 2018. Also a Lecturer in Dementia & Neurodegenerative Disorders at the Maurice Wohl Clinical Neuroscience Institute, King’s College London, her research focuses on molecular and cellular mechanisms of neurodegeneration in dementia and motor neuron diseases, especially those caused by repeat expansions. Obtaining her PhD from the University of Dundee, Sarah went on to complete postdoctoral training at UCL and was awarded the UCL Early Careers Neuroscience Prize in 2014. Sarah's lab at the UK DRI at King's investigates transport disruption between neuronal nuclear and cytoplasmic sub-compartments in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 

https://www.ukdri.ac.uk/team/sarah-mizielinska

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Guests

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Guest

Professor Chris Shaw

Professor Shaw is Director of the Maurice Wohl Clinical Neurosciences Institute a Group Leader in the UK Dementia Research Institute and Chief Clinical and Scientific Advisor to AviadoBio, a Gene Therapy company spunout from his laboratory. For 30 years he led a motor neuron disorders clinic at King’s College Hospital which underpinned his research exploring the genetics, molecular and cellular pathobiology of MND and Frontotemporal Dementia (FTD). His team have led the discovery of many MND and FTD genes and developed stem cell and transgenic mouse models of disease. These revealed important insights into disease mechanisms, identified novel drug targets and advanced genetic therapies using antisense oligonucleotides and viral vectors.  

https://www.ukdri.ac.uk/team/chris-shaw