The Chain: Protein Engineering Podcast
The Chain explores the lives, careers, research, and discoveries of protein engineers and scientists, the impact their work is having on the field, and where the industry is headed. Tune in to stay up-to-date on the newest advancements and to hear the stories that are impacting the world of biologics.
Episodes
74 episodes
PEGS Young Scientist Keynote Jessica Stark on the Role of Glycans in Cancer Research
In this episode of The Chain, host Brandon DeKosky, associate professor, speaks with MIT colleague Jessica Stark, Underwood-Prescott career development professor, about glycans and why they are important in cancer research. Stark discusses how ...
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Season 2
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Episode 71
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28:38
Episode: 70 - Views on Machine Learning and AI in the Antibody and Protein Engineering Space
March 11, 2025 | In this episode of The Chain, host Andrew Buchanan, principal scientist at AstraZeneca, and Andreas Plückthun, professor and head of biochemistry at the University of Zurich, discuss AI/ML technologies in the antibody an...
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Season 2
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Episode 70
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49:36
Episode: 69 - Conversation with Sir Greg Winter on the 50th Anniversary of the Milstein and Köhler Paper
February 21, 2025 | This episode marks the 50th anniversary of one of the most influential papers in biomedical science—the 1975 Milstein and Köhler paper on hybridoma technology, which paved the way for monoclonal antibodies. Ralph Mint...
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Season 2
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Episode 69
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50:36
Episode: 68 - Changing the Game of Protein-Protein Interactions With Randolph Lopez
In this episode of The Chain, host Andrew Bradbury, CSO of Specifica, an IQVIA business, speaks with Randolph Lopez, CTO and co-founder of A-Alpha Bio, about how A-Alpha Bio is changing the game of protein-protein interactions with their platfo...
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Season 3
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Episode 68
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46:00
Episode: 67 - Anthony Tolcher Discusses Oncology, Dual-Payload Technology, and the ADC Field
November 12, 2024 | In this episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, speaks with Anthony Tolcher, M.D., FRCPC, cofounder of NEXT Oncology, about antibody drug...
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Season 3
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Episode 67
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42:34
Episode: 66 - John Lambert on Antibody Drug Conjugates Then, Now, & Beyond
October 15, 2024 | In this month’s episode of The Chain, host Rakesh Dixit, PhD, DABT, president and founder of Bionavigen Oncology and Regio Biosciences, and John Lambert, PhD, consultant, about antibody drug conjugates (ADCs) then, now...
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Season 3
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Episode 66
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39:43
Episode 65- Tariq Ghayur on the Renaissance of Bispecifics and ADCs, AI, and More
September 10, 2024 | In this episode of The Chain, host Nimish Gera speaks with Tariq Ghayur, of Tariq Ghayur Consulting, LLC and Entrepreneur in Residence, FairJourney Biologics (and a fellow host of the podcast), about the current renaissance...
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Season 3
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Episode 65
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31:55
Episode: 64 - Peyton Greenside on AI’s Role in Antibody Engineering, Optimization, and More
In this episode of The Chain, host Nimish Gera, Ph.D., vice president of biologics at Mythic Therapeutics, speaks with Peyton Greenside, CSO and co-founder of BigHat Biosciences, about the role of AI and machine learning in antibody engineering...
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Season 3
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Episode 64
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32:31
Episode: 63 - Discussing Protein Signaling and Structural Biology With Andrew Kruse
In this episode of The Chain, host Brandon DeKosky, associate professor at MIT, speaks with Andrew Kruse, PhD, professor of biological chemistry and molecular pharmacology at Harvard University, about protein signaling and structural biology. K...
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Season 3
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Episode 63
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38:18
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Episode: 62 - AI/ML in Antibody Discovery and Engineering: Reality, Hope, Future, and Hype
his special episode of The Chain features a panel of industry experts who discussed AI and ML in antibody discovery and engineering at this year’s PEGS Boston event. Peter Tessier, professor at the University of Michigan; Andrew Bradbury, CSO a...
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Season 3
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Episode 62
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1:03:57
Episode: 61 - Tomoyuki Igawa Discusses Leadership and His Experiences in Discovery and Development
In this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in residence, FairJourney Biologics, speaks with Tomoyuki Igawa, PhD, chief executive officer, Chugai Pharmabody Research in Singapore, about his 20+ years of exp...
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Season 3
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Episode 61
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55:04
Episode: 60 - Lesley Millar-Nicholson on Technology Licensing, Navigating Patents, and Building Teams
This month The Chain shares a recent episode of the Lab Rats to Unicorns podcast. Lab Rats to Unicorns, hosted by John Flavin, aims to demystify the process of creating a great company in the life sciences, biotech, medtech, clean energy, and b...
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Season 3
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Episode 60
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48:14
Episode: 59 - Gabriel Rocklin on Protein Biophysics and Protein Design
In this month’s episode of The Chain, host Ben Hackel, professor of Chemical Engineering & Materials Science at the University of Minnesota, speaks with Gabriel Rocklin, assistant professor of Pharmacology at Northwestern University, about ...
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Season 3
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Episode 59
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33:10
Episode: 58 - Janine Schuurman Reflects on the Key Lessons and Accomplishments of Her 20-Year Career
How does one maintain innovation in the antibody industry? In this episode of The Chain, host Tariq Ghayur, PhD, consultant and entrepreneur in residence, FairJourney Biologics, talks with Janine Schuurman, PhD, president of The Antibody Societ...
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Season 3
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Episode 58
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55:05
Episode: 57 - The Future of Bispecific Antibody Drug Conjugates With Rakesh Dixit, Ph. D.
Bispecific antibody drug conjugates (ADCs) have been undergoing a renaissance in recent years. As big pharma continues to express more interest, what can the field expect for the future of ADCs? In this episode of The Chain, Nimish Gera, Ph. D....
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Season 3
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Episode 57
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33:06
Episode: 56 - Thomas Sakmar on the Golden Age for the Application of Biologics to GPCR Pharmacology
What can we expect from GPCRs in antibodies and biologics? In this episode of The Chain, host Rajesh Sundaresan, PhD, Scientific Leader and GSK Fellow of Protein Cell and Structural Sciences at GlaxoSmithKline, speaks with Thomas P. Sakmar, MD,...
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Season 3
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Episode 56
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44:38
Episode: 55 - Tala Fakhouri Discusses AI/ML for Biologics Drug Discovery & Development
In this episode of The Chain, Richard Bonneau, PhD, and Marcel Hop, PhD, of Genentech interview Tala Fakhouri, PhD, of the FDA on her thoughts on the discussion paper, “Using Artificial Intelligence & Machine Learning in the Development of ...
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Season 3
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Episode 55
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33:27
Episode: 54 - Enkelejda Miho on the Current State of AI: Drug Development, Research, and the Future
With the whirlwind development of AI, it can be difficult to keep track of its uses in both research and the market. In this episode of The Chain podcast, host Ben Hackel, Professor of Chemical Engineering & Materials Science at the Univers...
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Season 3
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Episode 54
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29:20
Episode: 53 - Jonathan Sockolosky on Breaking Into Biotech and Making Real Progress in Ovarian Cancer Treatments
What is the first step of getting into biotech? How do you make real progress in research? In honor of Ovarian Cancer Awareness Month, host Nimish Gera discusses these topics and more with Jonathan Sockolosky, PhD, Director of CSO Partner Team ...
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Season 3
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Episode 53
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26:48
Episode 52: Entrepreneurship in Immunotherapy: Capstan’s Adrian Bot on Teambuilding
In this episode of The Chain, Brandon Dekosky, Associate Professor at MIT, speaks with Adrian Bot, Founding Chief Scientific Officer and Executive Vice President of R&D at Capstan Therapeutics, about his experiences in leadership roles, his...
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Season 3
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Episode 52
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23:31
Episode: 51 - Setting the Right Strategy to Drive Engineering Parameters for Solid Tumor-Targeting T Cell-Engagers
In this special episode of The Chain, G. Jonah Rainey, Senior Director of Protein Engineering at Eli Lilly and Company, hosts a panel at PEGS 2023 to discuss strategies to engineer parameters for solid tumor-targeting T-cell-engagers. Guests St...
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Season 3
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Episode 51
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53:45
Episode: 50 - Pivoting Research with Antibody Drug Conjugates
In this month’s episode of The Chain, Greg M. Thurber, associate professor of chemical engineering and biomedical engineering at the University of Michigan, sits with moderator Nimish Gera, vice president of biologics at Mythic Therapeutics, to...
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Season 3
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Episode 50
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31:20
Episode: 49 - Building a Next Generation Bioproduction Platform
Kyron.Bio is revolutionizing drug production with its Next Generation Bioproduction Platform that will make the production of therapeutics easier, cheaper and faster. Voldborg and McLaughlin talk about their shared vision for using synthetic bi...
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Season 3
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Episode 49
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23:30
Episode: 48 - A Conversation with Peter Tessier: Classifying Antibodies to Assess Biologics Developability Features Early in the Discovery Process
In this month’s episode of the Chain, guest Peter Tessier, Albert M. Mattocks pharmaceutical sciences and chemical engineering professor at the University of Michigan, speaks with moderator Tariq Ghayur, scientific advisor and entrepreneur in r...
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Season 3
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Episode 48
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48:01
Episode: 47 - Bonus Episode with PEGS Young Scientist Keynote Dr. Andrew Anzalone on Engineering Prime Editor Proteins for Therapeutic Applications
Dr. Andrew Anzalone, head of the Prime Editing Platform and scientific co-founder at Prime Medicine, is the winner of the PEGS Boston 2023 Young Scientist Keynote. He was invited to sit down with Brandon DeKosky, assistant professor of chemical...
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Season 3
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Episode 47
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40:43
