The Power of Quercetin: The Super Antioxidant

Transform your health with quercetin. Discover its remarkable ability to combat free radicals and its potential transformative effect on your cells.

Join Adam Payne, CEO of Ultra Botanica, and host Josh Bellieu as they explore the complexities of quercetin in this episode of Ultra Life Today. 

Discover quercetin's potent antioxidant properties, its ability to chelate heavy metals, and its intricate interactions within cellular biology. The duo delves into its limited bioavailability and how their groundbreaking LPS technology amplifies its health benefits. They also discuss quercetin's potential roles in combating oxidative stress and metal toxicity, offering transformative insights into plant bioactives. 

Dive deeper into this enlightening conversation on quercetin by listening here or by watching on YouTube: https://youtu.be/NPJ9z9Dq4fQ

Visit UltraBotanica.com to learn more about us and how you can get a free sample of our products.

Transcript

0:00:00 - (Adam Payne): Quercetin is a polyphenol, like curcumin, that has a lot of domains of activity. These polyphenols tend to bind to a whole variety of stuff. So let's talk about the known domains of quercetin. So quercetin is a very powerful antioxidant. First of all, it's known to be when it's inside the cell or outside the cell, can attach to free radicals and essentially nullify their toxic ability that free radicals have that can damage cell membranes and the machinery inside of a cell.

0:00:51 - (Josh Bellieu): Hey there, everyone. Welcome to another edition of Ultralife Today. This is kind of our little Fireside Chat series where I get to sit down with the CEO of Ultra Botanica, Adam Payne, lead inventor of this incredible technology called lps. We've got another ingredient to talk about today.

0:01:10 - (Adam Payne): Drum roll.

0:01:10 - (Josh Bellieu): Hey, drum roll.

0:01:11 - (Adam Payne): I'm looking for the fire. Yeah, where's the fire? We're supposed to. Well, I mean. Fireside Chat, Josh. Oh, I'm sorry.

0:01:18 - (Josh Bellieu): You know, next time, I bet instead of our logo, they could probably put one up there.

0:01:24 - (Adam Payne): So we're having a conversation. We did the last one on curcumin.

0:01:28 - (Josh Bellieu): No, we did the last one on berberine. Can you say berberine? Sure.

0:01:33 - (Adam Payne): You can forget. Forgetting. Yeah, berberine. That's right. We did the last one on berberine. Now we're doing quercetin. The two of the. The second polyphenol that we've added into our technology.

0:01:45 - (Josh Bellieu): So before you go into that, I want to set this up. And. And we need to set it up because when I met you 10 years ago, you and B.G. currian and Hal Schofield were playing around with. They'd liquefied curcumin. They came to you, they said, we commercialize this, we want to get it into a free flowing powder. You guys sat around and did crazy shots of curcumin and got a curcumin buzz.

0:02:11 - (Adam Payne): Yeah.

0:02:12 - (Josh Bellieu): Guys figured out a technology called LPS technology. And the reason I'm bringing this up again is because we have another one of those problem ingredients, Adam. The LPS technology just to encapsulate it, pun intended.

0:02:27 - (Adam Payne): Wow, you're really rolling here.

0:02:29 - (Josh Bellieu): Is to be able to take these plant bioactive compounds that are polyphenols or flavonols or isoquinolones and get them into a form, a molecular form, where they'll literally move into the bloodstream and hit it at exponential levels and land on the cell receptor sites.

0:02:49 - (Adam Payne): Josh, there are so many of these compounds that have the promise of being something that should change our health, should have an impact on us. I mean how many times have there's so many of these kinds of ingredients that I call them faith based supplementation.

0:03:13 - (Josh Bellieu): Oh, that's a good one.

0:03:14 - (Adam Payne): You know where people, you know, they go to the health food store and they go to the. And I'm talking about your typical good health food store, like what you have in natural grocers where you get into the aisle and there's like lot too many choices and you're overwhelmed.

0:03:31 - (Josh Bellieu): Yeah. And you're gonna have massive amounts of products that have been extremely hot. Berberine, curcumin, quercetin, resveratrol, green tea.

0:03:41 - (Adam Payne): You remember Abner's nutrition down in.

0:03:43 - (Josh Bellieu): Oh sure.

0:03:44 - (Adam Payne): Where was down in Texas?

0:03:45 - (Josh Bellieu): Wichita Falls, baby.

0:03:46 - (Adam Payne): Yeah, we went there. This health food store had floor to ceiling racks full of ingredients I had never seen before.

0:03:57 - (Josh Bellieu): One of the small health food stores, by the way, I've ever been in.

0:04:00 - (Adam Payne): Yeah, it's amazing.

0:04:01 - (Josh Bellieu): She does her stuff.

0:04:02 - (Adam Payne): And so you know what happens. I observed these kinds of interactions. You go into the health food store and you go, hey, I'm dealing with skin, dry skin or these female issues or I don't deal with female, you know, these issues that you experience and sometimes most of the time they'll point you in the direction of something that should help support health in variety of different organ systems or immune system or whatnot.

0:04:32 - (Adam Payne): A lot of these compounds, quercetin and curcumin for example, have the promise of being something that should transform our lives. But most people don't experience any benefit.

0:04:46 - (Josh Bellieu): You know almost every abstract that I read on PubMed and that's the government's clinical repository for, for research articles related and it's. You'd be amazed. Go to pubmed.gov and look up any natural compound. You will be shocked at how many studies there are on substances like.

0:05:05 - (Adam Payne): It's overwhelming.

0:05:06 - (Josh Bellieu): Yeah, 26,000 on curcumin. But you know what's interesting?

0:05:09 - (Adam Payne): I'm curious. Cursing. How many did you, you know, I.

0:05:11 - (Josh Bellieu): Didn'T pull the number up but I will say this, the thing you find over and over again when we're looking up these types of plant bioactives is one thing. They start off the abstract and they end it with. However, the universal problem with these kind of substances is exactly bioavailability, Getting them in the bloodstream, getting them into the cell receptor site.

0:05:33 - (Adam Payne): So that's why I call them faith based stuff. Because the research for example on curcumin, curcumin was the natural product of the year back in 2016, 2017.

0:05:46 - (Josh Bellieu): That's probably one of the largest grossing products in the history of the health food industry by far.

0:05:52 - (Adam Payne): We predicted that it was going to be a billion dollar category rivaling aloe.

0:05:56 - (Josh Bellieu): Vera which has been around for 60, 70 years.

0:05:58 - (Adam Payne): But most people when they take it, they don't feel anything. It takes weeks for people to experience.

0:06:07 - (Josh Bellieu): A difference, as you would say. I'm going to go back in the Wayback Machine. One of our favorite part tunes from back in the day.

0:06:14 - (Adam Payne): Peabody.

0:06:15 - (Josh Bellieu): When I first went out into Oklahoma.

0:06:17 - (Adam Payne): That's right. What was that called?

0:06:18 - (Josh Bellieu): Sherman and Mr. Peabody.

0:06:19 - (Adam Payne): That's right. Yeah.

0:06:20 - (Josh Bellieu): First when I first went out into Oklahoma City, I had a mission. You and I had created these three day samples of the original ultracur with color of your shirt. The lid was.

0:06:32 - (Adam Payne): Yeah, my favorite color.

0:06:33 - (Josh Bellieu): And so I went out to all these. I went out to clinical nutritionists, compounding pharmacists, integrative MDs, naturopaths. And I said do you all sell curcumin human in your place? And I knew they were all hot to trot on it. Right? And they were all like yes we do. And I was like, I'd love to ask you a simple question. How much benefit have you seen in your patient population or with your clients as it relates to the use of curcumin to a man or woman? Adam. The answer was.

0:07:06 - (Josh Bellieu): I see. I see. It's so. So.

0:07:08 - (Adam Payne): Yeah.

0:07:08 - (Josh Bellieu): And to your point, 30 days, 60 days, taking large, large amounts. Not really feeling it.

0:07:15 - (Adam Payne): But even most. What gets me, you go to the reviews of some of these turmeric curcumin products. Same thing with quercetin and berberine for that matter. And bourbon's a little bit different. Bourbon does somewhat get in the body. It has a better bioavailability than curcumin and quercetin. But it's kind of like oh, it's a great product. I'm feeling better. But they don't really talk about dramatic results.

0:07:41 - (Josh Bellieu): Transformative.

0:07:42 - (Adam Payne): Your word transformative.

0:07:43 - (Josh Bellieu): That's. That's my favorite word. I stole it about 10 years ago.

0:07:46 - (Adam Payne): So let's talk about quercetin. Quercetin, it's spelled Q U E R C E T I N. Right now a lot of people say quercetin.

0:07:55 - (Josh Bellieu): I saw it listed as a, as a flavanol.

0:07:59 - (Adam Payne): Right. The flavanol is a.

0:08:01 - (Josh Bellieu): Is that a polyphenolic class? Okay, okay.

0:08:03 - (Adam Payne): Flavanols are classes of polyphenols that are of that exhibit Certain aromatic tendencies. So they're part. They're definitely. They have to be part of a plant extract, and it has to be of a natural extract.

0:08:20 - (Josh Bellieu): By the way, I have to say, Adam, I'm taking you so much more seriously when you're in your white lab coat. It's just a game changer.

0:08:29 - (Adam Payne): I don't know how to take that, Josh.

0:08:31 - (Josh Bellieu): It's a good thing.

0:08:31 - (Adam Payne): I know. I like my little web. I like my white lab coat.

0:08:36 - (Josh Bellieu): Okay, so it's a quercete. Quercetin.

0:08:39 - (Adam Payne): And this is Dr. We wear white lab coats in our production facility. Yeah. And I. Okay. It's on.

0:08:46 - (Josh Bellieu): It's flavanol. It's part of this polyphenolic group of plant bioactive compounds.

0:08:50 - (Adam Payne): Quercetin is also. It's produced by a number of different plant species. Unlike curcumin, which is really only made by the turmeric rhizome in the root of the plant.

0:09:02 - (Josh Bellieu): You know, my very favorite way to get cursing in my body other than our own product, is onions. I'm a huge onion guy, man. I cook with them and everything, making spaghetti sauces. And I'm a. I'm a cook. And so, yeah, and onions are phenomenal.

0:09:20 - (Adam Payne): How much quercetin is in onion?

0:09:22 - (Josh Bellieu): Well, I'll tell you something really interesting is that when you take the powdered forms of quercetin that are out there and you compare them just to eating a meal with onions, and you check blood levels, you can take off the chart amounts of powdered quercetin and maybe find 1% in the blood. But you can get higher amounts by eating, oh, the plants and different things like that.

0:09:46 - (Adam Payne): That's not surprising to me because essentially, in the plant, you're getting the LPS kind of effect. LPS stands for our patented technology, liquid protein scaffolding. We solubilize these compounds like quercetin, we get them into a liquid state, and it's in a liquid. It's a free molecule. Right. It's not bound to itself. The problem with polyphenols, this whole class, is that once they bind to themselves, they don't like to dissolve.

0:10:19 - (Josh Bellieu): They, like, invite all their cousins to the party. Don't they form into crystals?

0:10:22 - (Adam Payne): They form crystals, and those crystals are essentially insoluble. I liken it to swallowing quartz crystal. You're not going to get silicone in your blood by swallowing a bunch of.

0:10:33 - (Josh Bellieu): I actually know where that's going to end up, but we'll save that for another episode. It's going to be eliminated from the body, isn't it?

0:10:40 - (Adam Payne): Yes, a great portion of it. So many great phrases flowing through my mind. None of them appropriate for.

0:10:47 - (Josh Bellieu): And another thing about these polyphenolic compounds is that when they aggregate together and they form these crystals, they also have a tendency to create gastric. Gastric disturbances for people. Yeah.

0:11:02 - (Adam Payne): So that's more so for berberine.

0:11:05 - (Josh Bellieu): Berberine, okay.

0:11:06 - (Adam Payne): Yeah, berberine. Because berberine by itself is highly antimicrobial.

0:11:10 - (Josh Bellieu): Yeah. It's killing off everything. Right.

0:11:12 - (Adam Payne): It's like an antibiotic kind of curcumin can be a little bit abrasive to the gut. I don't know much about quercetin that's not absorbed. I do know that quercetin that is not absorbed isn't going to do much of. At all of anything.

0:11:26 - (Josh Bellieu): So we are going to be right back on Ultralife Today. I'm Josh Bellew sitting here with CEO of Ultra Botanica Adam Payne, and we're going to continue the conversation on Quercetin. Hey, do you love what we're doing? Go find podcasts anywhere you like to download them. Find us under Ultralife today. We've got a great YouTube channel as well. Learn more about our products@ultratoday.com.

0:11:50 - (Adam Payne): Our mission is to take nature's most beloved botanicals and enhance them with our liquid protein scaffold technology. This helps it reach your cells faster and better with exponentially enhanced bioavailability. You'll feel better every day. Ultra Botanica, the feel good curcumin.

0:12:17 - (Josh Bellieu): Hey, everyone. Welcome back to Ultralife Today. This is our second segment. Talking about Quercetin or Cursington is Dr. Joe Perita corrected us, right?

0:12:28 - (Adam Payne): No, he definitely corrected us.

0:12:29 - (Josh Bellieu): Well, I'm hanging out with Adam Payne, CEO of Ultra Botanica, lead inventor of this incredible LPS technology that is literally revolutionizing. And when I say that, it's true. We have doctors all over the world, Adam, for many, many years that have basically said, when you guys create a product that's in this plant bioactive category of polyphenols, sign me up, because it's the only one we'll use because it produce results in a very, very short period of time.

0:12:58 - (Josh Bellieu): Now, when it comes to cursing, I must admit I'm a little behind the eight ball. I don't know a ton about cursing. So I do remember something, though, that kind of got me really going when Covid first hit, you know, I was going into independent health food stores and going into national chains, and you would literally see a wall of cursing that would be from floor up to about five Feet high. And they were end capping it everywhere.

0:13:27 - (Josh Bellieu): Why were they doing that? I remember this whole idea of cytokine storms, this incredible inflammatory response. What were they trying to figure out there?

0:13:36 - (Adam Payne): Well, quercetin's a polyphenol, like curcumin, that has a lot of domains of activity. These polyphenols tend to bind to a whole variety of stuff. So let's talk about the known domains of quercetin. So quercetin is a very powerful antioxidant. First of all, it's known to be when it's inside the cell or outside the cell, it can attach to free radicals and essentially nullify their toxic ability that free radicals have that can damage cell membranes and the machinery inside of a cell.

0:14:18 - (Josh Bellieu): And for a second, just in case, I know we have a very highbrow audience that really studies their stuff, but free radicals, I remember there being a description of free radicals and how they work. But basically you have, what, an electron that actually unpairs itself from the cell and it starts, like, playing pinball, doesn't it, and creating some issues.

0:14:39 - (Adam Payne): There's so many different kind of ways, anecdotally, to kind of describe what's going on. But as the essential mechanism is how we produce energy, I'm going to dig back into the Wayback Machine here, pulling from our Mr. Peabody error here. The Krebs cycle. Okay, Right. The Krebs cycle is a whole process that happens in the mitochondria.

0:15:04 - (Josh Bellieu): Powerhouse of the cell.

0:15:05 - (Adam Payne): Powerhouse of the cell. That involves glucose coming in, oxygen coming in, and then.

0:15:12 - (Josh Bellieu): And there's minerals and things.

0:15:14 - (Adam Payne): Yeah, there's all sorts of different things.

0:15:16 - (Josh Bellieu): Potassium, calcium.

0:15:17 - (Adam Payne): Yeah, 52 different. 52 ATP, I believe, is the number that is produced by one cycle of the Krebs cycle, as opposed to glycolysis or glycosis, is what cancer cells use. And they use one glucose and create two ATP. Very inefficient, very interesting. In the process of the Krebs cycle. Imagine like a car engineering, Right. Car engine takes in gasoline and burns oxygen. It creates exhaust. The exhaust coming out of the mitochondria is free radicals.

0:16:01 - (Josh Bellieu): Oh, wow.

0:16:02 - (Adam Payne): The free radicals that are produced are essentially the exhaust from the Krebs cycle engine. And so our bodies are designed to sop up that exhaust those free radicals we have.

0:16:16 - (Josh Bellieu): That's the job of an antioxidant.

0:16:18 - (Adam Payne): Yes. Glutathione is our antioxidant, and we have glutathione constantly being brought into where the mitochondria are producing the free radicals. And Sopping it up and taking and neutralizing it. Some free radicals escape the antioxidant capacity of a cell, especially as our cells become damaged or mitochondria become damaged.

0:16:45 - (Josh Bellieu): No doubt. Diet, lack of supplementation, exercise has a whole host of things.

0:16:49 - (Adam Payne): And there are other processes that create free radicals. Like when we are attacking, when our bodies kill bacteria. That creates a lot of free radicals. Oxidative stress is another kind of description of what this whole process looks like. Oxidative stress being the Krebs cycle, using oxygen creates these free radicals. That causes metabolic stress or cellular stress on the body. The problem with free radicals is that they are damaging.

0:17:21 - (Adam Payne): They grab electron or they donate electrons to things around them. And those donated electrons can create chemical reactions that you don't want to happen. They can damage cell membrane structures. They can get involved in the machinery of what should be a normal smooth process into something that's not a smooth process. It can damage DNA. It can change a DNA's coding for something that's going on.

0:17:48 - (Adam Payne): So quercetin, first thing's an antioxidant, right.

0:17:54 - (Josh Bellieu): Considered a powerful one, especially if you could get it into the bloodstream. I know that glutathione is like the master.

0:18:00 - (Adam Payne): You know, we're not curcumin, guess what? Is also a very powerful antioxidant. That's so that's the first kind of capacity that that has been studied. I don't think anybody, I'm saying this and I'm probably wrong, has done a kind of a molecular tag. You know, you can tag molecules with different radioactive particles. You can see how they're. See if they go see what's happening. You can look at, at their activity. You can then use enzyme measurements to look at the enzyme capacity of these different things.

0:18:33 - (Adam Payne): I'm sure somebody's done some research on this and it's fascinating. So let's put to bed Antioxidant. Interesting.

0:18:40 - (Josh Bellieu): That's a benefit.

0:18:41 - (Adam Payne): Yep. Quercetin, like curcumin, can also chelate or take out of our body. Heavy metals that are lead, cadmium, mercury.

0:18:53 - (Josh Bellieu): Arsenic, the ones that really destroy and cripple our health that we get a lot of in our these days.

0:19:00 - (Adam Payne): Heavy metals are called heavy metals because guess what? They're heavy. These are big atoms and it's a heavy metal ion. And it's an ion. Imagine the closest analogy is like a wrecking ball. A heavy metal free just roaming around inside of your cell is literally like a wrecking ball.

0:19:24 - (Josh Bellieu): Just going three radicals on steroids that all agglomerated together.

0:19:29 - (Adam Payne): It's. It goes. It'll go through the cell wall. It'll destroy whatever is in its way as it's moving around. And it. Heavy metals damage cells.

0:19:40 - (Josh Bellieu): And don't they historically have a very difficult time escaping the body? Don't they want to abide in the tissues? A lot of them. Oh, heavy metals.

0:19:49 - (Adam Payne): This is the.

0:19:49 - (Josh Bellieu): It's hard to get them out. So you're telling me another benefit.

0:19:52 - (Adam Payne): They, when they. Especially when they're just wrecking balls, they. They're just going to continue damaging stuff.

0:19:58 - (Josh Bellieu): So querc.

0:19:59 - (Adam Payne): This is why mercury poisoning, lead, cadmium, arsenic poisoning, these are all heavy metals that the EPA tells us we need to be cognizant about how much we're taking in. Our body has a certain capacity to eliminate heavy metals, but it needs to do so by chelating them. And what I mean by chelation is these compounds. Curcumin's a chelator, especially a really good chelator of excess iron, which is really interesting, like for hematochromatosis. Hint, hint, wink, wink, say no more.

0:20:30 - (Josh Bellieu): Iron.

0:20:31 - (Adam Payne): Iron right over an overabundance of iron is actually bad.

0:20:34 - (Josh Bellieu): Argh.

0:20:35 - (Adam Payne): That damages the body just like heavy metal exposure. But quercetin can bind to these heavy metals and essentially inactivate them. So imagine a quercetin molecule wraps around the heavy metal ion and it activates it. And so then the body's able to deal with the heavy metal ion because it's not a wrecking ball anymore, you.

0:20:59 - (Josh Bellieu): Know, and that's one of the cool things I have found over the years and studying these plant bioactives, Adam, is when they do chelate something, when they go and basically smother it and bind to it and inactivate it. Some of these substances, especially radioactive type substances, can actually damage the kidneys when they're being eliminated. But plant bioactives inactivate them to such a capacity that when you're eliminating them, it does not create other problems. Compounding.

0:21:28 - (Adam Payne): So it's using the antioxidant capacity of the cursing or curcumin for that matter. And then it's binding to the heavy metal ion, so it attaches to that ion. And so then it's essentially not quite. Not completely inert, but the body's able to deal with it. It's not causing damage. It's not on that big chain and swinging through all the scaffolding of the cell and causing all sorts of damage.

0:21:52 - (Josh Bellieu): Wow. Antioxidant chelation, especially of heavy metals in this day and age, from the water supply, the air we breathe, the food. I mean, I mentioned this the other day and it bears repeating. A really cool organization named Moms Across America. I've got to get this plug in, go look them up. Lady named Zen Honeycutt. Their organization went to 40 different fast food restaurants to look for glyphosates and look for heavy metals in the food.

0:22:18 - (Adam Payne): I want to know.

0:22:20 - (Josh Bellieu): Disbelieving it is because many of these restaurants.

0:22:23 - (Adam Payne): Don't say it.

0:22:24 - (Josh Bellieu): Many of These restaurants had 18 to 20 to 50 times the levels of the EPA allowable for substances like cadmium, mercury, lead. Get away with that.

0:22:34 - (Adam Payne): And seriously.

0:22:35 - (Josh Bellieu): And the thing that broke my heart the most.

0:22:37 - (Adam Payne): Hold on, hold on a minute. So I mean, if I'm a food producer, I have to comply with, with food testing to make sure that my, the food I'm producing, like our nutritional supplements is not over the legal limits for heavy metals.

0:22:51 - (Josh Bellieu): Okay, here I go down the road that they call. I am looking at the camera right now. Regulatory capture. It's in every industry. It's in the pharmaceutical industry, it's in the food industry, it's in the oil industry. It's everything related to lobbyists and their ability to continue to do things and have people kind of just look the other way. And it's everywhere. And that's why, that's why I love consumer groups like this. I mean these are okay Moms Across America.

0:23:19 - (Adam Payne): So can dads play with them? Are we?

0:23:21 - (Josh Bellieu): Oh yeah, they would. I mean, Zen Honeycutt is cool.

0:23:25 - (Adam Payne): Can we have a Dads Across America?

0:23:26 - (Josh Bellieu): We could if you and I want to see Step.

0:23:28 - (Adam Payne): I'm a dad.

0:23:29 - (Josh Bellieu): We started. Oh yeah, four.

0:23:31 - (Adam Payne): Four dad. You're a four times dad.

0:23:33 - (Josh Bellieu): I am a four time dad.

0:23:34 - (Adam Payne): I'm a four times dad. @ least all that I know of. I don't, you know, talk about that.

0:23:39 - (Josh Bellieu): Okay. Antioxidant, chelating, any other benefits?

0:23:45 - (Adam Payne): Oh my gosh, yes.

0:23:46 - (Josh Bellieu): Come off the top of your head.

0:23:47 - (Adam Payne): So now we're getting into. So those are kind of the most polyphenols to my understanding have the ability to have antioxidant capacity and I believe has some chelation capacity. I could be wrong. I'm not a chemist. Contrary to everybody's popularity.

0:24:05 - (Josh Bellieu): And these are often brightly colored. So if we find them in the food supply, they tend to have a tendency. Right.

0:24:11 - (Adam Payne): They tend to have very specific wavelengths within which they will fluoresce, which is interesting. The polyphenol groups themselves lend it to that fluorescing activity. So now we're getting into some More what I would call ligand.

0:24:25 - (Josh Bellieu): And so with a minute and a half, let's start into this road of the next benefit that we've got.

0:24:30 - (Adam Payne): Okay, now we're getting into. Where does quercetin actually interact with a cell in its biology, not just dealing with heavy metals or antioxidants. But how does quercetin affect cellular biology?

0:24:46 - (Josh Bellieu): Well, I have a huge question mark above my head. I'm sure everybody can see it right now. I have no idea.

0:24:51 - (Adam Payne): We gotta make one. Can we. Can we get a question mark here?

0:24:55 - (Josh Bellieu): They can probably.

0:24:55 - (Adam Payne): I would love to see that.

0:24:56 - (Josh Bellieu): Probably superimpose one.

0:24:57 - (Adam Payne): Yeah, Done.

0:24:59 - (Josh Bellieu): Okay.

0:24:59 - (Adam Payne): Yep.

0:25:00 - (Josh Bellieu): All right. So anyway, you mentioned ligand and. And where.

0:25:04 - (Adam Payne): It's a fancy word.

0:25:05 - (Josh Bellieu): Okay. Where are we going with that? And what is a ligand?

0:25:07 - (Adam Payne): So ligand is technically a cell receptor. It's. So if you look, cells don't communicate by words. They can communicate a little bit by when they're touching other cells by electrical signals and some gradients around them. Primarily the way that a cell communicates to its outside environment by producing little soluble messenger molecules. We call them cytokines, chemokines, leukotrienes. And they get made and then they get expressed through the cell.

0:25:45 - (Adam Payne): So the cells produce these little soluble hormones. Then different cells in the body have the ability to receive those signals and then bring them into the cell as a communication.

0:26:02 - (Josh Bellieu): Hold that thought. We've been having a fascinating conversation on quercetin with Adam Payne, CEO, lead inventor, Ultra Beta Britannica. I am Josh Bell. You listen, you love what we're doing. Find us wherever you find podcasts. We're going to be going into another segment for our radio listeners. It's going to be next week's show, so we'll be right back with Ultra Life today.