MTHFR, B Vitamins & Genetic Testing: The Root Cause of Fatigue, Anxiety & Brain Fog?

Could your migraines, anxiety, or fatigue be rooted in your genes?

In this powerful episode of Ultra Life Today, clinical pharmacist Mary Jane Fry and Ultra Botanica’s Adam Payne unpack how genetic testing—specifically the 3x4 genetics test—can reveal critical imbalances like MTHFR mutations, poor B vitamin methylation, glutathione deficiencies, and even hidden histamine intolerance or gluten sensitivity.

Learn how these overlooked genetic factors can explain chronic symptoms like low energy, mood swings, brain fog, and poor detoxification—and discover how simple nutritional changes can make all the difference.

Listen to the full episode here or watch it on YouTube: https://youtu.be/kL0xFKt_nNo

Visit UltraBotanica.com to learn more about us and how you can get a free sample of our products.

Transcript

0:00:00 - (Adam Payne): So I was not in good shape in 2012. I think this. We left it off. I went to the Mayo Clinic because I was getting significant pain issues, significant muscular deficits, and coming back with the idiots diagnosis, I was kind of at a loss. And that's when I met Dr. Gantt and I started to do more functional things and where I learned. So I was able to do functional things about it. I added in methylated B vitamins into my diet.

0:00:30 - (Adam Payne): I was able to add in all sorts of other supplements that go along with that B vitamin supplementation. And I was able to, I think, functionally stop the progression of this disease or at least slow it down.

0:00:55 - (Josh Bellieu): Welcome to Ultra Life. Today we have a very fascinating person that we call a friend. Her name is Mary Jane Fry. Some of you, if you've never gone back into our archives and listen to any of the podcasts we've done with her, you are really going to enjoy it. I am one of your hosts. I'm Josh Bell.

0:01:13 - (Adam Payne): You, I'm Adam Payne, the other host. And you're all right, Josh, this Mary Jane. You are a friend.

0:01:20 - (Mary Jane Fry): Thank you.

0:01:21 - (Adam Payne): I feel like there should be some corny song we get playing right now, but it's true. There are people that you get to know and you appreciate them professionally, and there's people that you'd actually want to hang out with. And I really want toa say you're one of those people.

0:01:37 - (Mary Jane Fry): Well, I tell people all the time. My friends at Ultra Botanica.

0:01:41 - (Adam Payne): Oh, so there we go. I guess it's done then.

0:01:44 - (Josh Bellieu): We appreciate that. Mary Jane, there's people that haven't viewed you before and listened to you. And so I would love it if you would. Rather than me trying to tell your story, I would rather you take a couple of three minutes and give a little journey of your educational background why you're doing what you're doing now. And then we'll get into the fun stuff later about things you are learning and things that people need to know to be able to get to the root cause, those mystery illnesses.

0:02:14 - (Mary Jane Fry): So well, I am a pharmacist. I was educated in the early 80s at Weatherford. I loved pharmacy. I still love pharmacy, but I've shifted from the traditional realm of pharmacy into a consulting world of pharmacy with functional integrative medicine as my base. Like you said, the root cause. I think it kind of just evolved over years. Started with our compounding pharmacy, going to some seminars and learning about.

0:02:53 - (Josh Bellieu): That's right, you had a light bulb moment in the bioidentical hormone World.

0:02:57 - (Mary Jane Fry): Right, right.

0:02:58 - (Josh Bellieu): That was kind of the first part of your path.

0:03:00 - (Mary Jane Fry): It was the hormone replacement therapy. And then as the years went on, whenever we went to a seminar, they would say, well, we taught you about hormones. Now you need to look at thyroid. Now you need to look at adrenals, your energy, your fatigue. Now you have to look at what's going on in your gut. And now my latest place that I put things into is trying to piece the genetics into that and weave it into everything else.

0:03:32 - (Josh Bellieu): I got to ask you, because I'm really interested, who was sponsoring these seminars that you were going to? Was it some of the diagnostic testing companies that you now represent?

0:03:46 - (Mary Jane Fry): It's been. I don't consider myself representing anybody specifically, but you utilize some ofes.

0:03:54 - (Josh Bellieu): They're in your toolbox.

0:03:56 - (Mary Jane Fry): So first off was the Pharmacy Compounding Association. That was a number one place that we learned about the hormone replacement therapies. There was a seminar that I went to early on that was from the American College of Apothecaries. And so that was another place. And then ZRT is a saliva blood test company, and now they do urine strips also. So that company did some seminars in the past. And then nutritionally wise, I've been at seminars from all of the big functional medicine type nutritional companies.

0:04:39 - (Mary Jane Fry): Zymogen metagenics, orthomolecular AC or the other place was a 4M.

0:04:47 - (Josh Bellieu): Right.

0:04:48 - (Mary Jane Fry): Some training with them, some seminars. So lots of different places.

0:04:54 - (Josh Bellieu): Are most pharmacists or compounding pharmacists open to this world? I have found that most compounding pharmacists I know know far more than pharmacists that don't do any compounding. Is there any reason that you, your group was so open to pursuing these things?

0:05:15 - (Mary Jane Fry): The owner of the pharmacy originally, Don Cootie, he was in pharmacist for years and years, and he took an interest in nutraceuticals and brought in somebody back in the early 90s and trained us in some basics. And then from there it just kind of kept growing. I think the reason that the compounding pharmacies were getting into it was the niches that we could be able to be involved in. You weren't just making a compound, but you actually understood what was going on.

0:05:55 - (Mary Jane Fry): And then also early on, there weren't very many practitioners who were involved in it. So the practitioners were sending us the patients.

0:06:04 - (Josh Bellieu): So, Adam, and you running into pharmacists and all kinds of researchers that you've run into over the years, what is the tipping point for some of them? I mean, we've always talked about these personal crises, but how do people like your workout at ou these researchers begin to get interested in plant bioactive compounds and nutraceuticals and things like that.

0:06:25 - (Adam Payne): Well, it typically doesn't come from the pharmacy backwards. It usually comes from a researcher that is understanding either the basic research, which we've done an incredible job. You know, our hats off to the NIH for investing, I think, a couple of trillion dollars now into basic research to understand how our biology works from a fundamental basis. Even like the whole human genome project was a dream of, I don't know, was the Carter administration when that started and they were goingn, we're going to sequence the whole human genome and it was like one pair at a time. And then it was, we could do lots more.

0:07:13 - (Adam Payne): And then the technology is now that we can now sequence a whole human genome in a couple of hours. That's amazing what we can do. But it's the research drove insights into human biology and then there were all of these anecdotal pieces of evidence that were out in the natural medicine space that drove connections. So, you know, we. A friend of ours, a guy namedy, he's a. The retired Mike Stefen, the retired orthodontist.

0:07:54 - (Adam Payne): Have you met him?

0:07:55 - (Mary Jane Fry): Have.

0:07:55 - (Adam Payne): Oh, he's a really interesting guy. His pet hobby was understanding nutritional supplements because his whole thing was we are living in an era when for the first time in human history, we have access to concentrated bioactive plant compounds, vitamins, minerals, nutritional substances in a concentrated form. So now we can selectively and effectively dose the human body with these concentrated substances that heretofore have just been available in the.

0:08:36 - (Adam Payne): In the food that we eat, but now we can concentrate them and provide them as supplementation.

0:08:41 - (Josh Bellieu): I say tangue in cheek and Mike will appreciate this because you and I know how many supplements he takes and he's in shape. So I think a good percentage of his poundage is just the amount of capsules he takes on a daily basis. Mary Jane, no, you got to hear.

0:08:56 - (Adam Payne): Mar'Love I kid you not. When we met him, he was taking over a hundred different supplements on a daily basis. I seriously, it was like most a walking veg cap.

0:09:08 - (Josh Bellieu): Yeah.

0:09:08 - (Adam Payne): And he was healthy.

0:09:10 - (Josh Bellieu): He was healthy indeed.

0:09:11 - (Adam Payne): But it's. It was interesting the way he actually came to us because he said, I have to tell you a story. He said, adam, I have changed one thing in my life in the last six months and that was I added ultraur Pro to my regimen and I need to Tell you a story because I could never remember the names of my patient parents or my patients. And it was always befuddling to me. I'd have to like look at the chart and say okay, this is little Jimmy that's in here. And his parents are Amy and da da da D.

0:09:46 - (Adam Payne): And so he would like refresh himself. He said after taking ultraurr Pro he could not only remember the name of his patient, he knew their parents names. He could remember the dog that they have. He'd walk in and say, ah, you know, hi Jimmy and Mary and Ann and da da da da da da. And he said reflectively, the only thing he changed is ultracur Pro. He was convinced that this was like the newest thing in memory.

0:10:14 - (Mary Jane Fry): Well, just last week when I was listening to that memory Summit ye there were some of them talking about the curcumin.

0:10:21 - (Adam Payne): Really. So somehow clearing up the connections or what were they saying?

0:10:26 - (Mary Jane Fry): Well, it was just really brief, but it had to do with the inflammation.

0:10:31 - (Adam Payne): Oh, interesting.

0:10:31 - (Mary Jane Fry): Know. So I think that's interesting. I think when you ask the question about where is the trigger, the starting point. Mark Hyman, I know he had a health issue. So many different.

0:10:46 - (Josh Bellieu): Yeah.

0:10:47 - (Mary Jane Fry): Sarah Gotatfield had.

0:10:48 - (Josh Bellieu): Yeah, we've just seen that over and over and over during our interviews.

0:10:52 - (Mary Jane Fry): Right. And mine proably mine was probably my premature son and my mother aging at the same time and me trying to put together, you know, what I could do for.

0:11:06 - (Josh Bellieu): Wow, you're like super mom to do both of those things at the same time.

0:11:10 - (Adam Payne): Well, you live with the, with the cards that you're dealt.

0:11:13 - (Josh Bellieu): Righteah.

0:11:14 - (Adam Payne): You don't get to choose.

0:11:15 - (Josh Bellieu): That's right.

0:11:16 - (Mary Jane Fry): Well God gives us.

0:11:17 - (Adam Payne): Yes.

0:11:18 - (Mary Jane Fry): Things that make a difference and grace.

0:11:21 - (Josh Bellieu): To overcome in the moment.

0:11:22 - (Mary Jane Fry): Right, Absolutely.

0:11:24 - (Josh Bellieu): Grace to overcome in the moment. So is there anything that you have been doing lately? And I know we've. And we probably need to revisit just for a little bit your move into utilizing genetics. We were talking off camera just before this started and you were saying there's a reason that I do this and I do it because there's these categories of things that I learn. So help people understand in the name of the test that you prefer because you've done some research, you like the people, you like the solid science of what they put together and continue to evolve that.

0:12:00 - (Josh Bellieu): Tell us a little bit about that.

0:12:01 - (Mary Jane Fry): Again, 3 by 4 genetics. So it's 3x4 genetics is how you type it in. They take a pathway driven approach. And what that means is instead of looking at Just MTHFR or looking at.

0:12:18 - (Josh Bellieu): Okay, hold the phone. For those of you that don't know, Mary Jane is going to tell you what the MTHFR gene is.

0:12:26 - (Mary Jane Fry): It's a methylfolate reductase gene.

0:12:30 - (Josh Bellieu): Okay.

0:12:31 - (Mary Jane Fry): So what that is is part of our methylation pathway which has to do with how we process our DNA, how we process our B vitamins and other nutrients for supporting our DNA, supporting mood, heart, all different parts of our system.

0:12:54 - (Josh Bellieu): So for a second, because we've never talked really about methylation, I don't believe with any of these podcasts, Adam, you have a really personal thing about that. And then I'd love Mary Jane to come along and tell us a few things she learns it is a personal thing. Right?

0:13:11 - (Adam Payne): Well, I mean it's.

0:13:12 - (Josh Bellieu): So you had an issue, you didn't know what it was. Right.

0:13:16 - (Adam Payne): A small issue. So we were talking about Charlie Gant. Remember a little bit earlier? Right. He actually I did my first genome scan using ancestry.com do and when he was still alive, Dr. Gant took me under his wing and he threw my genome into a tool that he had.

0:13:35 - (Josh Bellieu): I thought you were goingna say under.

0:13:36 - (Adam Payne): The bust did yeah, you're doomed, just go sit in a corner and die. No, he threw into this tool that essentially mapped out which genes are recessive, which are similar to 3x4 a lot less elegant. It, it spat out like a 20 page report that was color coded similar to, to that. And he had 12 genes that were related to the MTHFR and I was red in all of them. I am literally recessive on every single MTHFR gene.

0:14:13 - (Josh Bellieu): Now how did that affect the way you feel, Adam? Because I know I feel great about that.

0:14:18 - (Adam Payne): No, no.

0:14:20 - (Josh Bellieu): Okay, I'll take off my psychiatry hat now and I'll put on my commentator hat again. How did that manifest in your body?

0:14:28 - (Adam Payne): O well, I meanive, not only that, but I'm also recessive in all the B B vitamins which are really interesting. So I don't recycle B vitamins, I don't. I slowly turn them into energy. So my mitochondria have a hell of a time creating energy in my body, but it's resulted in significant motor neuron deficits in my legs and in my peripheral nerves. It manifests itself in functional loss. Josh is the short answer of it.

0:15:00 - (Adam Payne): But it also provided insight into where I could functionally supplement myself and find some, not just relief, but the ability to slow down the progression. So in 2012 I went to the Mayo Clinic and they said that I had something called I was an idiot. No, no, idiopathicathic and I have an idiot's disease. It's called idiopathy. No, idiopathic peripheral neuropathy, which is a shorthand for you have peripheral neuropathy and we have no idea where it's coming from.

0:15:36 - (Josh Bellieu): Okay, this is a great time for us to segue into another segment here now. We will be right back with Mary Jane Fry, pharmacist, Very interesting woman that does some neat things. One thing I love about her is she's always learning. So this is Ultral Life Today. I'm Josh Bell.

0:15:52 - (Adam Payne): You Addam Payne.

0:15:53 - (Josh Bellieu): We'll be right back.

0:15:54 - (Adam Payne): Stay tuned.

0:16:41 - (Josh Bellieu): Welcome back to Ultral Life Today we've got our very special guest, Mary Jane Fry with us. We've been going down a path of genetics talking about the MTHFR gene. Adam has been sharing that he's recessive there and in a number of other areas. And we are back. That was not a backhand. You're bashing me. I am trying to elevate. Yeah, I am trying to elevate the knowledge.

0:17:10 - (Adam Payne): Let me say this. So I was not in good shape in 2000. I think as we left it off. I went to the Mayo Clinic because I was getting significant pain issues, significant muscular deficits, and coming back with idiots diagnosis. I was kind of at a loss. And that's when I met Dr. Gantt and I started to do more functional things and where I learned. So I was able to do functional things about it. I added in methylated B vitamins into my diet.

0:17:41 - (Adam Payne): I was able to add in all sorts of other supplements that go along with that B vitamin supplementation. And I was able to, I think, functionally stop the progression of this disease or at least slow it down.

0:17:57 - (Josh Bellieu): And your body is now rejecting these nut is now accepting these nutrients that you're putting into it. Whereas before you could have been taking big handfuls of supplements and it just wasn't going to work. Right.

0:18:07 - (Adam Payne): And that's the rub. I mean, you could have measured B vitamins in my blood and looks like they look high.

0:18:13 - (Mary Jane Fry): A lot of times actually when you don't process your B12.

0:18:18 - (Josh Bellieu): Well, that makes sense.

0:18:18 - (Mary Jane Fry): Kind of the B12 level will look chi and they'll say, oh, you have to stop. And it's like, no, let's look at what's actually happening. Because if it doesn't process through the methylation system, it's just sitting there in the serum and that's all they look at. So now we look at different Places to be able to see the nutrients so that we know that they're getting to the system.

0:18:44 - (Adam Payne): So Br Gann, Brian Gant, Brian Frank actually did a really interesting test where they take doctors, I. I know terr so many doctors where he took cell samples from my mouth and they actually cultured those cells and looked at functional outputs of when you provided nutrients to those cells, how they actually process.

0:19:07 - (Josh Bellieu): That's cool.

0:19:08 - (Mary Jane Fry): N. Oh no, I haven't heard of that.

0:19:10 - (Adam Payne): Yeah, so I got some insight from that and it really. So it's just absolutely amazing the number of ways that we can look at functionally how our bodies are operating in order to provide insight into what we could be doing to remediate what's going on if there is a deficit.

0:19:33 - (Josh Bellieu): So you do this three by four genetic test. I said that. Right. That's what it's called. Okay. And you find some people, because I know you've done a lot of this, you find some people that you realize are not methylating B vitamins. Tell me how that affects behavior, mood, cognitive ability, other things in a person's life. Because a lot of people are just like, I just take my daily multivitamin and I don't care if it's synthetic or whatever, it's just supposed to do it kind of thing.

0:20:00 - (Josh Bellieu): But obviously a lot of people aren't getting out of their supplements what they need to. So you're unlocking a door where they can. What happens with an individual that's deficient and B vitamins and can't methylate them?

0:20:10 - (Mary Jane Fry): So there's lots of different things that can be their symptom that throws them into trying to figure it out. It can be headaches, it can be infertility, it can be depression, it can be cardiovascular. So there's a lot going on. The one thing that early on when they were just looking at that methylation mthfr, they were overmethylating sometimes because some people are heterozygous, which means they got the gene from one parent and sometimes they're homozygous, which means they got it from both parents.

0:20:46 - (Mary Jane Fry): And when it comes to methylation, their higher propensity towards risk is when it's homozygous. So if somebody were heterozygous at the be beginning and there's two different ones, actually there's two different MTHFRS. So if you were heterozygousin 1 and you were homozygous negative per se, it's not the right term, but you were in the. The potent I'm not danger zone of deficiency. Well, there's. You can be homozygous and not have any effect at all and you can be homozygous and it have high impact of risk. Ok, that's the way to say it.

0:21:28 - (Mary Jane Fry): So some people early on were finding out that they were heterozygous in one of the two genes, SNPs and they were getting put on high doses of methylfolate. But now because of the way we get pathways, not everybody is like adam and has 11 different methylation snips that are off. But so we can look at those methylation pieces and tell whether somebody has a little need for methylfolate or if they have a high need for methylfolate, if they have a need for B12 or if they have a need for choline, they have a need for other nutrients. So it's not always about methylfolate. Now, there's other pieces to how methylation occurs in our system.

0:22:19 - (Josh Bellieu): When you mention headaches, I know what continually run into people that have migraines that take them out for, you know, two days sometimes. Is that the kind of headache? I mean, could it actually manifest into a migraine when you are not.

0:22:33 - (Mary Jane Fry): If you don't methylate properly? Absolutely.

0:22:35 - (Josh Bellieu): Wow.

0:22:36 - (Mary Jane Fry): Methylation is part of our detoxing system also, so. So you don't always know where else you're going. Headaches can be hormonal, headaches can be toxins, headaches can be inflammation. So there's lots of different places, but in three by four we can look at each pathway, look at all of the SNPs in that pathway and be able to tell potentially it's all risk potentials of what's going on. You also throw in the lifestyle, the diet and some people will have a high propensity towards something and it not exhibit itself in them because they've already done the lifestyle, they've done the diet'exercise going on.

0:23:23 - (Josh Bellieu): So got the clean living.

0:23:25 - (Adam Payne): But let's set a foundation here though, because most people are going through life absolutely naive as to their genetic makeup. Absolutely, absolutely right. And they don't know what to take. They go to the maybe that maybe they'll have a functional dog that'll say, hey, we need to do some testing. And not all functional docs or even not everybody that comes into your clinic or into your store gets tested. Right.

0:23:53 - (Adam Payne): But it's typically driven by some sort of manifestation of disease or an issue that starts the whole thing. Right. So that's true.

0:24:01 - (Mary Jane Fry): But hopefully over the years, as the price comes down. We will start with genetics. I was talking to a woman the other day and I said, we really should be checking your grandchild.

0:24:12 - (Adam Payne): Absolutely. I mean, this, this is the point I was getting to, is that we should be starting life with a genetic kind of roadmap, saying, hey, for this person, these are going to be the kinds of nutritional, biochemical challenges that they are going to be facing. And let's imprint some lifestyle issues now that will help that person. You know, it's like you steer the ship a little bit now, you can be in an entirely different place.

0:24:42 - (Adam Payne): You know, 20 years down the line.

0:24:43 - (Mary Jane Fry): I've seen so many people who are gluten sensitive.

0:24:46 - (Adam Payne): Oh my gosh, talk about a transformation.

0:24:49 - (Mary Jane Fry): When you see the changes, when the test shows up. So the genetic testing is not specifically for just gluten sensitivity. It's a test in our profile, the blueprint, the 3x4, that actually is looking at a risk of celiac disease. So if somebody has the combination of SNPs that go together in that pathway, the risk for celiac disease can be 75%.

0:25:24 - (Adam Payne): Wow.

0:25:25 - (Mary Jane Fry): So that's the highest risk. But there's other combinations of the SNPs and alleles that would put them into potentially just being sensitive to gluten. And so there's different ways to see that. I had a friend whose granddaughter was three or four years old, super pale, always having stomach trouble. And finally somebody tested her for celiac. And within a month, her entire structure.

0:25:56 - (Adam Payne): Features, everything, demeanor, everything changed, everything. So, I mean, just a recent thing in my life, my wife, you know, constant problems, headaches, sleep cycles that were all out of whack all the time. She finally figured out after working with Dr. Wyndham that she was sensitive to gluten. And she was, she struggled with it. She's like, oh my gosh, everything I love is gluten. She finally. She bit the bullet and she's eliminated from her life.

0:26:28 - (Adam Payne): And it's like whole. I'm meeting a whole new person.

0:26:32 - (Mary Jane Fry): It's amazing what it can do.

0:26:34 - (Josh Bellieu): It is magical, isn't it?

0:26:35 - (Adam Payne): It's a truly. I'm grateful.

0:26:38 - (Josh Bellieu): Yeeah, absolutely.

0:26:40 - (Mary Jane Fry): So other places in the pathways, there's a histamine pathway.

0:26:44 - (Adam Payne): Oh, yeah.

0:26:44 - (Mary Jane Fry): So you can have external allergies like you're dealing with, or you can have allergies that have to do with foods that raise systemine levels. But we found that there's probiotics that lower histamine levels in the system, there's foods that lower histamines. In the system, there's an enzyme that can lower histamine in the system. So by seeing that we can find different ways and histamines in the typical world we just think of antihistamines.

0:27:18 - (Mary Jane Fry): You have an allergy, you know what that allergy is, you stay away from it. But in reality it can be headaches, it can be hormone issues, it can be sleep issues. High histamine can be a sleep trigger or a lack of sleep trigger. So histamine is another whole world that has been opened up.

0:27:41 - (Josh Bellieu): And just so our viewers understand, you've walked down this thing where you mentioned things like headaches and migraines and that could be because they're not methylating B vitamins. You mentioned gluten and celiac disease. And if you've ever been around a person like Adam says that truly didn't know and then they changed their diet, their mental health, everything changes. It happens so quickly. It's just mind boggling sleep cycles like that. And then you mentioned histamine.

0:28:09 - (Josh Bellieu): I want everybody to recognize you're learning all this just from this one test, the three by four, right?

0:28:14 - (Mary Jane Fry): Absolutely.

0:28:15 - (Josh Bellieu): YesK And I know there's some other categories, so please.

0:28:18 - (Mary Jane Fry): So it's risk potentials always. So we're not going to say you are celiac.

0:28:24 - (Josh Bellieu): Right.

0:28:25 - (Mary Jane Fry): You know it's a risk potential for celiac or you are going to have an issue with histamine because you might have eliminated those foods already and not be right. So everything is a risk potential. So the main four cellular pathways are detoxification, inflammation, methylation and oxidative stress. So one of my stories is I've had a foot. My left foot has peeled for 20 years.

0:28:54 - (Adam Payne): Wow.

0:28:55 - (Mary Jane Fry): Maybe even 25 years now. Right foot, no peeling. Left foot const peeling. And when I did my genetics, I found out that I don't have all of the proper processes when it comes to glutathione. And glutathione, a major master antioxidant, master antioxidant, master detoxifier. So in being able to add a couple of supplements, my foot is so much better. But it cleared, you know, some of those toxins or whatever'going on through the left side of your body.

0:29:33 - (Mary Jane Fry): Years ago a doc had told me, well, it's the left side of your body, so it has to do with detoxification.

0:29:40 - (Adam Payne): What? Why, why does the left side have to do the detet detoxification?

0:29:45 - (Mary Jane Fry): This woman, she actually had like three or four different degrees and she said, our left side of our body is how we detox things out of our system.

0:29:53 - (Adam Payne): Wow. So I would love to know why that is.

0:29:56 - (Mary Jane Fry): I don't know.

0:29:57 - (Josh Bellieu): Mary Jane's gonna find out for you. We'll talk about it next time.

0:30:01 - (Mary Jane Fry): Right, Will.

0:30:01 - (Adam Payne): So, I mean, have you clinically seen this? And as you've gone through life.

0:30:05 - (Mary Jane Fry): Well, because May, I've only done the genetics like two years ago, but I'm making progress.

0:30:10 - (Adam Payne): Yeah, but in other people.

0:30:13 - (Mary Jane Fry): Every once in a while, somebody will tell me that their left foot has what they think is a toe fungus, when it's not probably a toe fungus.

0:30:21 - (Adam Payne): It's probably something. A detoxification maybe.

0:30:24 - (Josh Bellieu): So, Mary Jane, with just a couple of minutes left before this next break, when you mentioned your inability to process glutathione and then you said you took a couple of supplements, Adam and I do not mind if people talk about other supplements on our broadcast. We have a special niche with a couple of things that we do, and we do it really, really well here. But I'm very curious because there's people out there probably taking glutathione, thinking it's doing great for them. What were the cofactors that helped your body begin to be able to process glutathione?

0:30:59 - (Mary Jane Fry): So sulfuraphane.

0:31:01 - (Josh Bellieu): Okay, Sulforane.

0:31:03 - (Mary Jane Fry): Right. One of those pro products. But sulfuraphane is. I don't know that I'm saying that it so forame.

0:31:11 - (Josh Bellieu): But yesah. It's racist, basically, like a precursor. Right. It's the glucina elevate the glucin, but.

0:31:17 - (Mary Jane Fry): You have to have myrosinase with it, which is the enzyme that breaks it down. So it comes from broccoli. But there's different ways to get it. And some people will say, I'm taking this product and if it doesn't have the right way to process it within the product, or you don't have the myroinase in your system at that moment, then you don't get as much of a benefit.

0:31:42 - (Josh Bellieu): Where does my rosnse come from? And how do people end up supplementing with it?

0:31:48 - (Mary Jane Fry): Well, there are companies and I've listened to people talk about them, but I haven't ever used them. But there are products that they say if it's the broccoli sprout and it's the raw powder, then you're going to get the myrosinase with it. So that's what some people, they hold their head on. That Zymogen has come up with a combination of the suluraphane with myrosinase. They've sourced the actual myrosinase.

0:32:16 - (Mary Jane Fry): Put it together. And that's what I'm taking right now.

0:32:19 - (Josh Bellieu): Okay.

0:32:20 - (Adam Payne): Interesting.

0:32:20 - (Josh Bellieu): Clever idea. Okay, well, this is Ultra Life Today. I'm one of your hosts, Josh Bell. You.

0:32:25 - (Adam Payne): I m Madam Payne, and we've been having a discussion with Mary Jane Fry. Next week will be returning to our discussion and continuing on in the fascinating journey. Stay tuned.