Starving Cancer? Dr. Thomas Seyfried on Keto, Fasting & Low-Dose Chemo (Part 2)

Dr. Thomas Seyfried returns for Part 2 of our deep dive into the metabolic theory of cancer—and this time we get practical.

In this episode, Professor Seyfried (Biology, Boston College), author of Cancer as a Metabolic Disease, explains how glucose and glutamine fuel tumor cells and why managing cancer as a mitochondrial metabolic disorder changes everything about prevention and therapy.

We discuss:
* Why keeping blood sugar low and ketones elevated (nutritional ketosis) creates a hostile environment for cancer cells
* How he uses the Glucose Ketone Index (GKI) to guide diet and fasting
* The idea of “press-pulse” therapy – long-term metabolic pressure plus short, targeted hits
* Combining ketogenic metabolic therapy with low-dose chemotherapy
* Why some patients and clinicians are exploring antiparasitic drugs (like mebendazole/fenbendazole) as glutamine-targeting tools
* The role of exercise, fasting, and evolutionary biology in protecting mitochondria
* Why he believes the genetic model of cancer is failing patients – and what a future metabolic standard of care could look like

If you or someone you love is dealing with cancer—or you’re serious about prevention—this conversation is essential listening. 

Listen here or watch the interview on YouTube: https://youtu.be/dp9um-MwMck

Disclaimer: This discussion is for educational purposes only and does not provide medical advice, diagnosis, treatment, or cures. Always work with your own qualified healthcare professional before making any changes to your diet, medications, or treatment plan.

Watch Part 1 with Dr. Seyfried for the scientific foundations of the metabolic model of cancer: https://youtu.be/l-_63d2Gkzc

About Dr. Thomas SeyfriedDr. Seyfried is a professor of biology at Boston College and author of “Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer.” His work builds on and expands the Warburg hypothesis, arguing that mitochondrial dysfunction and fermentation are at the heart of cancer biology.

Visit UltraBotanica.com to learn more about us and how you can get a free sample of our products.

Transcript

0:00:00 - (Dr. Thomas Seyfried): When you're in nutritional ketosis, where your glucose is low and your ketones are elevated and you're in the, in the 3 to 23 0, that, that range, you can take a very small dose of chemotherapy, even less than half of what they would normally give you. And boy, it just blows the out of these tumor cells because they're already vulnerable. Now you're putting them on a life support system.

0:00:23 - (Kyle Drew): That's right. They're starving.

0:00:25 - (Dr. Thomas Seyfried): They're starving and, and they're going to die. And they are dying. And then you throw in a tiny amount of chemo and the next thing you know, it's history for these tumor cells.

0:00:42 - (Kyle Drew): Hi everybody and welcome to another episode of Ultra Life Today. My name is Kyle Drew, meat eating, tofu hating nutritionist. So glad that you're joining us. You know, we're. We had a part one conversation with Dr. Thomas Seyfried, professor of biology at Boston College. And it was riveting and it was technical. We decided to break that episode up into two different episodes. And what you're about to see is our part two to our conversation with Dr. Seyfried. Now this one, what I found is that toward the end of the long conversation that we had, Dr. Seyfried became a lot more practical, a lot more what can we do about it?

0:01:31 - (Kyle Drew): He talks about therapeutic strategies, but also prevention strategies. He talks about diet, he talks about exercise. He talks about these antiparasite drugs like fenbendazole, mebendazole, et cetera, et cetera.

0:01:47 - (Dr. Thomas Seyfried): These.

0:01:47 - (Kyle Drew): This is well worth sending to your friends who have an active diagnosis and I'm anxious for you to listen to what we have. Let me tell you this. Ultra Life today is brought to you by Ultra Botanica, makers of the super absorbable high intensity curcumin. You can feel, it's called Ultracur. Also the makers of the pathway system products. A lot of folks are taking this who follow the metabolic model of cancer.

0:02:17 - (Kyle Drew): They are taking this alongside some other things that they've seen out and about on the Internet. It is just a series of nutritional supplements that help nutritionally support the rebalancing of metabolic pathways that are imbalanced due to cancer and other diseases. It is not a treatment, it is not a cure, it is not even a prevention. There is no way that the FDA needs to worry about what we're saying about this.

0:02:46 - (Kyle Drew): It is a series of dietary supplements. Now I do need to say this, this is important just because I just told you about the pathway supplements as we're about to move into Dr. Seyfried's conversation. Do not take that as Dr. Seyfried's endorsement of these products. He doesn't know about these products. I don't want to imply in any way that Dr. Seyfried is saying, see metabolic model. Oh, you guys with your product. He doesn't know about these products.

0:03:17 - (Kyle Drew): And so please don't take that as Dr. Seyfried's endorsement. But we did want to attach that little pitch alongside the conversation, because Dr. Seyfried's metabolic model is what these pathway products are built on. So without further ado, Here is part two to our conversation with Dr. Thomas Seyfried. I remember years ago when I spoke to you on a radio show, the question was, should everybody consider a ketogenic diet, or at least a primitive diet, something that really limits glucose?

0:03:58 - (Kyle Drew): Whether or not we become ketotic is a different question, but that was the question then, and that's the question that I'll put to you now, just in your opinion, still on the prevention side.

0:04:10 - (Dr. Thomas Seyfried): Yeah. Well, I think cancer is a very preventable disease, conceptually. In practice, it's not. Right. Because we are now, our Paleolithic ancestors never had access to the highly processed carbohydrates, emotional stress, lack of exercise, poor sleep. What was killing those folks was injuries and infections. They had no orthopedic surgeons or antibiotics. So they were dying from injuries and infection. They weren't dying from cancer and cardiovascular disease.

0:04:40 - (Kyle Drew): Right.

0:04:41 - (Dr. Thomas Seyfried): It's not that they didn't live long. Yeah. And a lot of times they couldn't because they didn't have an antibiotic. But those guys who, who could survive. And we, we have, we have tribes in Africa where you can have old people in the 80s and who have never, never succumbed to those problems. But, but clearly the problem is, is the, is the temptation of our daily lives for putting our mitochondria at risk.

0:05:07 - (Dr. Thomas Seyfried): There we go. We, we are still Paleolithic man living in a totally different environment, and we have an obesity epidemic. That's. I say obesity is evolution in action. Those genes that allowed us to survive these horrible droughts and, and famines and all this kind of stuff. We are supremely, metabolically designed to store energy because if we did not have the capacity to store energy, you and I would not exist on the planet today.

0:05:35 - (Kyle Drew): No.

0:05:37 - (Dr. Thomas Seyfried): So now we take that same highly precise body and put it immersed in all kinds of highly processed carbs wherever you look, in drinks, in food, and of course. And you don't exercise. And the next thing you know, you're obese and you're at risk for cancer, diabetes, cardiovascular disease, dementia.

0:05:54 - (Kyle Drew): Yes.

0:05:56 - (Dr. Thomas Seyfried): It'S very understandable. But without an understanding of evolutionary biology, which is unfortunate, an affliction of the 90% of people in the medical field, you end up with this nonsense stuff that doesn't make any sense.

0:06:12 - (Kyle Drew): I think you're right. I think you're right. And so as we're moving from prevention to therapeutic strategies, one of the first things that went into my mind as you began talking about Warburg on the glucose side and then your work on the glutamine side. Okay, I think about two extreme kinds of diets, and I'll let you speak for yourself, but I just wanted to get your take on this. I talk to cancer patients all day, every day, and there are those who are juicing all the time.

0:06:46 - (Kyle Drew): And, boy, the vegetables and the fruits, it's got to be great. And the amount of sugar is astonishing that they're taking in. And then on the other side, there's the carnivore types with just nothing but meat, nothing but eggs. Protein, protein, protein. And because I'm less up on the ideas around the glutamine fermentation, I wonder first about protein intake. A classic ketogenic diet really limits protein.

0:07:21 - (Kyle Drew): But I'm wondering first of all, can you talk a little bit about protein intake when somebody does have an active diagnosis?

0:07:29 - (Dr. Thomas Seyfried): Well, that's why we use the gki, the glucose ketone index, because, I mean, I did it on myself. I ate rib eye steaks and bacon and eggs and hamburgers. Mix hamburger meat mixed in with eggs. I did the whole thing for about a week. And I. And I got my GKI down to about 10 in 5 days. If you get 2.0. If you're in 10, you're in a prevention zone. But if you want to kill cancer cells and manage chronic diseases, you should get down about 2.0 or below, which is. Which can be a real challenge.

0:08:00 - (Dr. Thomas Seyfried): But I made a mistake in eating too much of the meat. You know, you're hungry. You know, you have a tomahawk rib eye with. With one spear of asparagus, and. And it's really delicious. You pour butter on top of it? Yep. Or sauce bearnaise. It's all egg yolks and fat.

0:08:22 - (Kyle Drew): You betcha.

0:08:23 - (Dr. Thomas Seyfried): And then you measure your GKI and see what it is. And I said, if I do it again, listen, if I had cancer, I know what to do. But. But. And you become a lot more motivated than when you're just playing around with it.

0:08:34 - (Kyle Drew): It's the truth that changes. Talk to a cancer patient who knows this and who's doing it right, and you will see what inspiration is.

0:08:43 - (Dr. Thomas Seyfried): Yeah, right.

0:08:43 - (Kyle Drew): Yeah.

0:08:44 - (Dr. Thomas Seyfried): I mean, when you know your is on the line, you'd be surprised how smart you become in a short period of time.

0:08:48 - (Kyle Drew): No kidding. No kidding. You're right. And so, and so that's. That's the one side. And then you've got the juicers.

0:08:57 - (Dr. Thomas Seyfried): Well, I don't know what to say about the juicers. If you're throwing a lot of glucose into the system, I don't see how that could possibly be healing when the tumor cell needs the sugar. So, you know, we have to look at it long term as well. And then, you know, we don't throw out all parts of standard of care. What we're seeing in our clinics in Istanbul, Turkey, is a combination of ketogenic metabolic therapy with low dose chemo.

0:09:26 - (Kyle Drew): Mm, interesting.

0:09:28 - (Dr. Thomas Seyfried): Yeah. When you're in nutritional ketosis, where your glucose is low and your ketones are elevated and you're in the, in the 3 to 23 0, that, that range, you can take a very small dose of chemotherapy, even less than half of what they would normally give you. And boy, it just blows the out of these tumor cells because. Because they're already vulnerable. Now you're putting them on, on a life support system.

0:09:51 - (Kyle Drew): That's right. They're starving.

0:09:53 - (Dr. Thomas Seyfried): They're starving and they're going to die. And they are dying. And then you throw in a tiny amount of chemo and the next thing you know, it's history for these tumor cells. And we're getting results on pancreatic cancer. Three and four, three and five years of survival.

0:10:06 - (Kyle Drew): Goodness.

0:10:07 - (Dr. Thomas Seyfried): Yeah. It's unbelievable. But, you know, nobody's doing this. No, there's. There's nobody. There's no trial anywhere in the world that we know of. And we even wrote the protocols for doing the trials. Nobody's doing it. They're doing reduced glucose. They might be doing glutamine targeting without reducing glucose. They're not doing the full package.

0:10:28 - (Kyle Drew): Right.

0:10:29 - (Dr. Thomas Seyfried): And you got to do the full package correctly. You need to know upfront what that individual's blood work looks like. How many other comorbidities does the patient have when they're first diagnosed with cancer? If they're looking pretty healthy and they don't have any comorbidities, then we can go right in real quick. We put them on a zero carb diet for 14 to 20 days. Your body gets started, gets acclimated to this absence of glucose. And then we do water only fasting. And then we hit them with the parasite drugs.

0:10:58 - (Kyle Drew): Okay, good. I want to talk about that. That's a big one.

0:11:02 - (Dr. Thomas Seyfried): They're.

0:11:03 - (Kyle Drew): They target the glutamine pathway, the fenben, the me bin.

0:11:07 - (Dr. Thomas Seyfried): Well, I only tested mbendazole. We haven't tested fenbendazole.

0:11:13 - (Kyle Drew): Gotcha.

0:11:13 - (Dr. Thomas Seyfried): We have. We have not tested ivermectin. But here's what I did. If you go and look at parasites, a variety, there's a whole family of different kinds of parasites. You find out that when. When they're occupying tissue in their, in their resting state or existing state, rather than proliferation for reproduction, they're using mitochondrial substrate level phosphorylation.

0:11:36 - (Kyle Drew): Great. Here we go. Just as the cancer cells are astonishing.

0:11:41 - (Dr. Thomas Seyfried): So it's a neat way. Yeah. But there, you gotta hit, you gotta hit the glucose and glutamine with the parasite medication. And you know, we have Don6 Deoxynor Leucine, which is really powerful, but it does damage to your gut. So we've gotta figure out ways to monitor. Listen, we can manage these cancers at such a. On the cheap, minimal toxicity. What are you talking about here?

0:12:02 - (Kyle Drew): It's astonishing. And this is. I won't get conspiratorial. The thing that I was wanting to get your opinion on. Fasting. Whenever we're talking about pure water fasting for a period of time, do you have first a recommendation, those of us who have no diagnosis, any recommendation about how often and how long we should fast? Just for prevention, first of all.

0:12:28 - (Dr. Thomas Seyfried): Yeah. You know, I can't make any kind of recommendations.

0:12:31 - (Kyle Drew): Okay.

0:12:32 - (Dr. Thomas Seyfried): It's based on the person, the age, the sex, the general health. All of these things have to be taken into consideration when, when moving someone into these conditions. I can tell you from personal experience, going cold turkey and doing water fasting ain't easy.

0:12:47 - (Kyle Drew): Nope.

0:12:48 - (Dr. Thomas Seyfried): And it's, It's a turn off. Can you please give me the high dose chemo. Thank you.

0:12:53 - (Kyle Drew): It's. I'll tell you, it. It can be tough. There are sort of chronic fasters and they've sort of gotten used to that whole experience. But when you're going into the therapy model, and I want to ask you. And we'll come, we'll bring it in for a landing in just a moment. But you talk about something called press pulse strategy. Could you describe that just a little bit for those who have never heard this?

0:13:18 - (Dr. Thomas Seyfried): Well, it's a concept that I picked up from the field of paleobiology, from Ahrens and West published a paper. These paleobiologists looking at events in the history of our planet with mass extinctions of organisms. We've had these mass extinctions, you know, hundreds of millions of years ago, we've had mass extinctions. And the question is, it was always a combination of a chronic stress, weeding out weak members of the societies of organisms that existed at that time.

0:13:46 - (Dr. Thomas Seyfried): But it got rid of the weak, but not all the strong and the tough were able to survive. And then you have a pulse like a meteor or a series of volcanoes going off. And that was it. That was, was a complete extermination of every. So I just took the same concept. I said, how do we get rid of cancers? That we could use the same concept. Great.

0:14:06 - (Kyle Drew): Like that idea? It's so good. Okay.

0:14:09 - (Dr. Thomas Seyfried): Again, it's evolutionary biology, otherwise you don't know what the hell you're doing.

0:14:13 - (Kyle Drew): What is press in this paradigm?

0:14:16 - (Dr. Thomas Seyfried): Press, we can hold glucose down because we evolved to be in a glucose restricted environment. We didn't have delicatessens and donut shops on every corner. So our ancestors were always in a state of low glucose and elevated ketones.

0:14:31 - (Kyle Drew): So. That's right.

0:14:32 - (Dr. Thomas Seyfried): Not. Not because they wanted to be in that state. They had no choice. I mean, throw it in there.

0:14:39 - (Kyle Drew): It wasn't willpower.

0:14:41 - (Dr. Thomas Seyfried): You throw in a hot pizza to those caveman, you see what happens, right?

0:14:44 - (Kyle Drew): You better believe it.

0:14:47 - (Dr. Thomas Seyfried): They'd kill each other for a bite of the pizza.

0:14:49 - (Kyle Drew): You know it, you know it. That's the press side and then the pulse side.

0:14:54 - (Dr. Thomas Seyfried): Well, we have two presses.

0:14:56 - (Kyle Drew): Two presses.

0:14:57 - (Dr. Thomas Seyfried): We have the ketogenic metabolic therapy, which lowers the blood sugar, elevates the ketones. And you can take ketone supplements like Dom d' Agostino talks about, boost the ketones up a little bit. But then we have exercise. Extremely important. You can walk at what lowers blood sugar. The muscles will take glucose out of the bloodstream. And once the muscle takes the glucose, it does not share. This is an evolutionarily concerned because. Because if you're. The muscles are sharing their sugar with the brain and other. All of a sudden the lion comes and you don't have the capability of running away from the lion.

0:15:32 - (Kyle Drew): That's true, that's true.

0:15:35 - (Dr. Thomas Seyfried): So you need. The muscle needs to keep the glucose for a burst of quick action. The brain will suck up whatever, whatever sugar is hanging around. And the last guy on the totem pole is the tumor cell.

0:15:47 - (Kyle Drew): There we go.

0:15:48 - (Dr. Thomas Seyfried): Even with gluconeogenesis, you can't produce enough. Enough sugar to keep those tumor cells alive.

0:15:54 - (Kyle Drew): That's. That was the question. Gluconeogenesis and again, protein. And. Yeah, the transformation. Yeah.

0:16:01 - (Dr. Thomas Seyfried): So you're just. Just marginalizing this poor tumor cell. You feel bad for them in their existence. You know, there's. You have to feel like these poor suffering and the rest of your body is getting healthier and healthier.

0:16:13 - (Kyle Drew): There we go.

0:16:14 - (Dr. Thomas Seyfried): We go.

0:16:14 - (Kyle Drew): Beautiful.

0:16:15 - (Dr. Thomas Seyfried): Yeah, yeah. So. And then you come in with the glutamine targeting drugs and pulsing. Because if you're too aggressive, you can harm your gut. And the very cells, the immune cells that are needed for picking up the dead tumor cells are your immune system. So you don't want to paralyze them with a pressing of the glutamine. And the other thing that we have shown and others, the metastatic cancer cell, the cell that metastasizes and spreads through your body, is a hybrid between a cancer cell and a macrophage part of our immune system.

0:16:47 - (Dr. Thomas Seyfried): Interesting. So, yeah, they fuse. There's a fuse agenda. There's a lot of people who know about this, but everybody knows about. Except National Cancer Institute.

0:16:57 - (Kyle Drew): The experts.

0:16:58 - (Dr. Thomas Seyfried): Yeah, the experts. Right. That's why we have 1700 people a day dying from these experts. You got to go back to look at the dead people. They're all piling up, right? Because I know. Because the academic and pharmaceutical companies have no clue what we're talking about here. And if they do have a clue, they try to ignore it because it's too unsettling to the. To the establishment. And that's their personal.

0:17:20 - (Dr. Thomas Seyfried): Their personal misfortune. But it's. But it's also impacting negatively on the. On the people. And I feel so bad because I see all these people suffering and dying needlessly. It's just a tragedy of. Of monumental proportions. We don't have to have that. But. But the bottom line is that you have these metastatic cancer cells. Now, macrophages are an extremely powerful glucose glutamine consumer glutamine, a fuel for the immune system.

0:17:45 - (Dr. Thomas Seyfried): So you have a cell of the immune system, like a macrophage or a neutrophil, a leukocyte fusing with a tumor cell. And now you have a rogue macrophage already genetically programmed to spread throughout the body.

0:17:58 - (Kyle Drew): Goodness.

0:17:59 - (Dr. Thomas Seyfried): When you have a wound or something like that, the monocytes come pouring out of the bloodstream and go into the wound to heal the wound. They throw growth factors and cytokines and do all this stuff. And when the wound Is not healing. They fuse together to even facilitate greater wound healing. But if the cancer cell is throwing out lactic acid like a wound, Then the immune cells are behaving as they're genetically programmed, But. But in an abnormal context.

0:18:23 - (Dr. Thomas Seyfried): Oh, so then you all of a sudden you get this fuse hybridization and then these things spread all through your body, and everybody's poisoning your body and shooting radiation and all this crazy. And these things can't live without glucose and glutamine. What the hell?

0:18:37 - (Kyle Drew): And so it just seems reasonable. Press and pulse. This combination. And this is what you are seeing is really beginning to change the dynamic of how the precious few patients who have been exposed to this, and maybe they found a clinician that can hold their hands, but there are so few. And oh, how I want everybody to know about this.

0:19:03 - (Dr. Thomas Seyfried): Yeah, well, you have to know about it like I'm speaking. But when you start seeing the science as we have published, the mechanisms and the pathways and the evidence in pre clinical studies, don't forget I do all my work with preclinical studies.

0:19:15 - (Kyle Drew): Right.

0:19:16 - (Dr. Thomas Seyfried): And then I and I have an army of physicians that. That are out there that want to use this stuff. And then you got to try to rein in the physicians because they all want to throw everything at the problem, you know, oh, well, a little of this work, A little berberine here, you know, a little of this there's. And I said, yeah, we'll get to the heart. If you want to throw something at the cancer patient, Like a supplement or anything, Just make sure it doesn't harm them. Because you can get benefit from a placebo effect by doing one of these things. But as long as you're pulling, holding the restriction of the glucose and the glutamine, and then you can use small dose doses of radiation or chemo, you can use immunotherapies.

0:19:49 - (Dr. Thomas Seyfried): Oh, you hear them advertised every night on tv. How wonderful it is. And they spend more time telling you how it's going to kill you Than how it's going to save you.

0:19:57 - (Kyle Drew): You betcha.

0:19:58 - (Dr. Thomas Seyfried): And the reason why it doesn't work for a lot of people Is because the acidification of the tumor microenvironment Blocks the ability of the immunotherapy to work. And the acidification is the waste products of glucose and glutamine. So we know why these things don't work. We know. We know more about this problem than anybody else on the planet. And we have the evidence to support, Both scientifically and clinically, the evidence to support what we're saying the problem is we. When the NIH tells you it's a genetic disease, you can't, you can't think another way. And the academics are getting millions of dollars in research grants doing the same crazy. That hasn't worked for 50 years.

0:20:36 - (Dr. Thomas Seyfried): So the pharmaceutical companies are making hand over fist on drugs that they have no interest.

0:20:42 - (Kyle Drew): Right.

0:20:43 - (Dr. Thomas Seyfried): It's a mess up and down the whole system. But if you want to live and you want to be healthy, do metabolic therapy and have somebody that really understands what's going on. Well, and you go down to the clinics, go to the top medical schools and ask them, do you know anything about targeting glucose? I never heard of it. Eat as much sugar as you want. Glucose is nuts.

0:21:03 - (Kyle Drew): Yes, almost. Their strategy almost ensures the chronicity of the disease.

0:21:10 - (Dr. Thomas Seyfried): Yes. I don't think they're doing it purposefully.

0:21:13 - (Kyle Drew): Of course not.

0:21:14 - (Dr. Thomas Seyfried): They're doing it out of lack of knowledge and training that never brought them to understand what we're talking about.

0:21:20 - (Kyle Drew): Well, if more and more of them could be turned on to the work of you and your colleagues, I think that we could have a revolution. Oh, if that day could come, it wouldn't be too soon.

0:21:33 - (Dr. Thomas Seyfried): Well, you have the people on your side.

0:21:36 - (Kyle Drew): You sure do, man.

0:21:38 - (Dr. Thomas Seyfried): You do. You've got the folks, you have the people that really would want to benefit establishment. The system is not on your side.

0:21:46 - (Kyle Drew): That's it. It's the system. That's exactly right. Well, I got to tell you, Dr. Seyfried, what you have devoted your life to is well worthwhile. Not everybody can say that. And I just say, God bless you. Keep up the good work. I can't wait to see the continued studies that you and your colleagues will publish. Do you see what can you envision? What's next in the, in the metabolic terrain concept?

0:22:17 - (Dr. Thomas Seyfried): Yeah. And also it's important to mention that the research that we do is all supported by private foundations in philanthropy.

0:22:25 - (Kyle Drew): Goodness gracious.

0:22:26 - (Dr. Thomas Seyfried): Yeah. I mean, I. My career earlier on was supported by NIH grants all the way up for, for decades. But then when you start doing this kind of stuff that really is not part of the, it's not part of.

0:22:37 - (Kyle Drew): The mainstream, part of, it's not part of the script.

0:22:39 - (Dr. Thomas Seyfried): It'll be the way, It'll be the new standard of care.

0:22:42 - (Kyle Drew): Uh huh.

0:22:43 - (Dr. Thomas Seyfried): But getting there is like walking on hot rocks.

0:22:46 - (Kyle Drew): I believe it.

0:22:47 - (Dr. Thomas Seyfried): But so we have people that, that support our foundations and there are some people who say, I don't care if I need, if I make money on this. In other words, Philanthropy without strings. They just want to see. They just want to see people alive and healthy. And. And the. And. And what we're doing now is we're trying to find a tumor cell that's not dependent on glucose and glutamine. We haven't found any yet. So.

0:23:11 - (Kyle Drew): Still looking, huh? Still looking.

0:23:13 - (Dr. Thomas Seyfried): We're looking colon, breast, pancreatic, you name it.

0:23:17 - (Kyle Drew): What about liquid tumors? The leukemias and lymphomas?

0:23:20 - (Dr. Thomas Seyfried): They're blowing out lactic acid and succinic acid.

0:23:23 - (Kyle Drew): Wow.

0:23:24 - (Dr. Thomas Seyfried): And they collect lipid drops. We. We. The lipid. Here's the crazy thing. The people in the cancer field say, oh, they're using lipids like crazy because they've got all these lipid droplets in the cytoplasm.

0:23:35 - (Kyle Drew): Yeah.

0:23:35 - (Dr. Thomas Seyfried): The reason the lipid droplets are there is because the mitochondria can't metabolize the fatty acids. So you. You put them in lipid drops as a protective mechanism, because if you start burning fatty acids, you're going to produce ROS and kill the tumor cell.

0:23:49 - (Kyle Drew): It's just. It folds on itself. Astonishing. Astonishing.

0:23:55 - (Dr. Thomas Seyfried): And 90% of the papers in the top science and nature journals are saying cancer cells use fatty acids readily because all the stored fatty acids in the cytoplasm, little did they know they're there. So the tumor doesn't die.

0:24:10 - (Kyle Drew): You are right. That has been cited over and over again in response, kind of pushing back on the idea of keto. And so I think that's.

0:24:21 - (Dr. Thomas Seyfried): Yeah, yeah, it's just. It's just amazing. But, you know, as we say, the journey is worth the fight. The journey is what keeps us going because we know we're right and we want to have people not dying. I mean, these poor people coming out of these cancer clinics, they're bald and they've got mucositis. They've got all kinds of stuff. I never found a cancer cell in the hair follicle of anybody. Why are you losing your hair? What are you trying. There's cancer cells in your hair. I don't know why you're going bald.

0:24:50 - (Dr. Thomas Seyfried): But. But they shouldn't have to lose hair. They shouldn't have to have all these adverse side effects and killing cancer cells very strategically. Nobody. And then you run down. You hear people hear what I say. They run down to their oncologists at the top, MD Anderson, Sloan Kettering, wherever they go, and they get slapped down, they get angry, and they throw them out. It's just absolutely. It's a tragedy.

0:25:12 - (Kyle Drew): We talk to cancer patients all the time, and it's almost as if there are two types of patients. The ones who know better than to say certain things and. And then those that are going to be berated because they don't know any better.

0:25:30 - (Dr. Thomas Seyfried): Well, I feel bad because, you know, even if I were to have cancer, I have my colleagues. Even though I designed the experiments and tested everything, you still want somebody to talk to you. Do you want a clinician who can help you negotiate some of these things that you might not have heard about and that he has and therefore, you know, walk you through the process and give you some level of encouragement and monitoring. And you're monitoring at the same time with your GKI and you're taking the dosage of medication that will target the glutamine and you want to make sure those dosages and timings are right for you and your body.

0:26:10 - (Dr. Thomas Seyfried): And you want that person to know that and help you. And I would talk to my friends next door about this.

0:26:16 - (Kyle Drew): Yes.

0:26:16 - (Dr. Thomas Seyfried): And unfortunately I have all this information and know what to do if I had to do it. But most 99% of cancer patients don't have this.

0:26:25 - (Kyle Drew): No, no, absolutely not. And that's why it's so important to get this message out on platforms where the lay public. I love talking to cancer patients and they bring up your name. I love it when they have found you somehow on podcasts, some of your speeches. This is terrific. We are humbled and we're grateful that you would be on this podcast. We hope to have you back someday. Boy, oh boy. Keep it up.

0:26:52 - (Kyle Drew): Keep it up. Professor, thank you for what you do.

0:26:54 - (Dr. Thomas Seyfried): Well, we, we will. We won't stop until we start seeing the consistent drop in cancer deaths year in and year out.

0:27:01 - (Kyle Drew): Yes.

0:27:01 - (Dr. Thomas Seyfried): When you. The needle needs to move.

0:27:04 - (Kyle Drew): Well, just since we've started this podcast, about 70. 70 people have died. That's cancer.

0:27:11 - (Dr. Thomas Seyfried): That's right.

0:27:12 - (Kyle Drew): That's it's.

0:27:13 - (Dr. Thomas Seyfried): Which is.

0:27:13 - (Kyle Drew): It's high time we get that closer to zero. And we're not going to do it if we keep chasing the. The somatic genetic model. It's just faulty. It doesn't work. Here's where we need to be. And I thank you for taking the arrows because I know you're taking a lot, but thank you for taking the arrows, brother. Right. Does make might.

0:27:35 - (Dr. Thomas Seyfried): Yeah. Well, thank you very much. Pleasure.

0:27:37 - (Kyle Drew): Thank you, professor, thank you for watching Ultra Life today. Well, that was a power packed episode. I hope you enjoyed it. Dr. Thomas Seyfried really is a legend. I put him on the Mount Rushmore of most important cancer researchers. Of our time right there with Dr. Otto Warburg and others. So glad that you not only watch, but we thank you doubly for telling your friends. Please pass this along. Please subscribe.

0:28:09 - (Kyle Drew): Please like these episodes? We're going to do more like this very, very shortly. We are grateful that you are joining us for for each episode of Ultralife today.