Talking About Tumors with Ryann and Ryan - A medical oncology podcast

02_08 Early HER-2 positive breast cancer

February 14, 2023 Talking About Tumors Season 2 Episode 8
Talking About Tumors with Ryann and Ryan - A medical oncology podcast
02_08 Early HER-2 positive breast cancer
Show Notes

  1. Role of adjuvant HER-2 Agents and during of therapy
  2. Chemotherapy backbone considerations
  3. Pathologic complete response
  4. Neoadjuvant systemic therapy and response modified approach


As always, citations, and sources include education from our respective training programs, the Devita textbook, and  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.

DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015. Waltham, MA: Wolters Kluwer.

Some highlighted references recommended to read related to this specific episode:

1.von Minckwitz G et al. NEJM. 2019;380(7):617-628. doi:10.1056/NEJMOA1814017/

2.von Minckwitz G et al. NEJM. 2017;377(2):122-131. doi:10.1056/NEJMOA1703643/

3.Slamon D et al.. NEJM. 2011;365(14):1273-1283. doi:10.1056/NEJMOA0910383

4.Piccart M et al. JCO. 2021;39(13):1448-1457. doi:10.1200/JCO.20.01204

5.Martin M  et al. Lancet Oncol. 2017;18(12):1688-1700. doi:10.1016/S1470-2045(17)30717-9

6.von Minckwitz G et al. NEJM. 2019;380(7):617-628. doi:10.1056/NEJMOA1814017/

7.Gianni L et al. Lancet Oncol. 2014;15(6):640-647. doi:10.1016/S1470-2045(14)70080-4

8.Symmans WF et al.. J Clin Oncol. 2017;35(10):1049-1060. doi:10.1200/JCO.2015.63.1010

9.Gianni L et al. Lancet Oncol. 2016;17(6):791-800. doi:10.1016/S1470-2045(16)00163-7

10.Gianni L et al. Lancet Oncol. 2012;13(1):25-32. doi:10.1016/S1470-2045(11)70336-9

11.Gilboa S et al. Eur J Cancer. 2021;153:190-202. doi:10.1016/J.EJCA.2021.04.044

12.Tolaney SM et al. NEJM. 2015;372(2):134-141. doi:10.1056/NEJMOA1406281/

13.Cameron D et al. Lancet. 2017;389(10075):1195-1205. doi:10.1016/S0140-6736(16)32616-2

14.Earl HM et al. Lancet. 2019;393(10191):2599-2612. doi:10.1016/S0140-6736(19)30650-6

15.Pivot X et al. Lancet. 2019;393(10191):2591-2598. doi:10.1016/S0140-6736(19)30653-1

16.Perez EA et al. J Clin Oncol. 2014;32(33):3744-3752. doi:10.1200/JCO.2014.55.5730

17.Romond EH et al. NEJM. 2005;353(16):1673-1684. doi:10.1056/NEJMOA052122/

18.Ennis S et al.. NEJM. 2001;344(11):783-792. doi:10.1056/NEJM200103153441101

19.Hudis CA. NEJM. 2007;357(1):39-51. doi:10.1056/NEJMRA043186

20.Slamon DJ et al. Science. 1987;235(4785):182-191. doi:10.1126/SCIENCE.3798106



Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 


Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology