Talking About Tumors with Ryann and Ryan - A medical oncology podcast
Designed for residents and fellows to provide an overview of the clinical practice and evidence behind management of each individual tumor site. Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, cancer
Episodes
48 episodes
04_09 Testicular Cancer I
1. Background, work up2. Staging of seminoma and NSGCT3. Young Adult/Adolescent Oncology4. Management of Stage I Disease CitationsAs always, citations, and sources include education from our respective trai...
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Season 4
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Episode 9
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28:18
04_08 Metastatic Renal Cell Carcinoma
1. Historical Approach (cytoreduction, IFN-a, sunitinib2. Prognostic risk scores3. Evidence for modern doublet regimens4. Later line therapyCitationsAs always, citations, and sources include education from our respecti...
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Season 4
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Episode 8
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24:16
04_07 Localized Renal Cell Carcinoma
1. Risk Factors and Presentation2. Staging and Paraneoplastic syndromes3. Localized Therapy Options and Considerations4. Evidence and Limitations for Adjuvant Systemic Therapy CitationsAs always, citations,...
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Season 4
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Episode 7
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25:15
04_06 Metastatic Urothelial Cancer
1. Immunohistochemistry of urothelial cancer2. History of systemic therapy in advanced and metastatic disease3. Pembrolizumab and Enfortumab Vedotin4. Approach to second line therapy and beyondCitationsAs always, citat...
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Season 4
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Episode 6
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24:33
04_05 Muscle Invasive Bladder Cancer
1. Etymology, presentation, and work-up of bladder/urothelial cancer2. Role of perioperative systemic therapy3. Tri-modality therapy (bladder sparing approach)4. Considerations for upper tract urothelial cancer Cit...
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Season 4
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Episode 5
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29:16
01_14 Ampullary Carcinoma (Mini Discussion)
1. Clinical presentation and work-up2. Intestinal and pancreatobiliary subtypes3. Role of perioperative therapy4. Considerations for metastatic diseaseCitationsAs always, citations, and sources include education...
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Season 1
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Episode 14
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10:59
04_04 Castrate Resistant Metastatic Prostate Cancer
1. On continuation of ADT and ARAT switch2. Systemic therapy options after progression3. Improper mandated crossover4. PARP inhibitors in prostate cancerCitationsAs always, citations, and sources include educati...
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Season 4
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Episode 4
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24:50
04_03 Metastatic Castrate Sensitive Prostate Cancer
1. The chemotherapy revolution in prostate cancer2. Role of ARATs in earlier disease states3. Triple therapy (chemotherapy, ADT, and ARAT)4. Considerations for frailer patients with indolent disease CitationsAs al...
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Season 4
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Episode 3
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29:02
04_02 Adjuvant Options for Prostate Cancer
1. Physiology, efficacy and toxicities of androgen deprivation2. Evidence for adjuvant intervention after definitive surgery or radiation3. Role of abiraterone in high-risk localized prostate cancer4. Limited evidence to support def...
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Season 4
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Episode 2
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28:41
04_01 Fundamentals of Localized Prostate Cancer
1. Background and presentation of prostate Cancer2. Evidence behind PSA screening and hallmarks of a screening test3. Staging and risk stratification of Localized Disease4. Management options and the ProtecT TrialCitations
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Season 4
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Episode 1
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31:59
04_00 Introduction (Updated 12.17.23)
We have updated our initial introduction and are re-posting it here as well as in the initial file.
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Season 4
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Episode 0
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3:38
03_13 Head and Neck Cancer – Locally advanced and metastatic
1. Role for definitive chemotherapy and radiation2. Controversy on induction chemotherapy3. Considerations for nasopharyngeal cancer4. Approach to metastatic HNSCCCitationsAs always, citations, and sources include educ...
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Season 3
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Episode 13
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37:18
03_12 Head and Neck Cancer – Background and adjuvant considerations
1. Anatomy, diagnostic work-up and staging2. Field cancerization3. Indications for adjuvant concurrent chemoradiation4. Evidence to support weekly cisplatin with concurrent radiationCitationsAs always, citations, and s...
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Season 3
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Episode 12
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23:28
03_11 Mesothelioma and a bit of Large Cell Neuroendocrine Carcinoma
1. Presentation, and considerations for regional mesothelioma2. Systemic therapy options for advanced mesothelioma3. Corticosteroids for pemetrexed, paclitaxel and docetaxel4. A quick review on considerations for LCNEC C...
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Season 3
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Episode 11
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29:40
03_10 Small cell lung cancer
1. Background on SCLC2. Approach to treatment by stage3. Emerging discussion on prophylactic cranial irradiation4. Brief review of basket and umbrella trialsCitationsAs always, citations, and sources include education ...
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Season 3
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Episode 10
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33:31
03_09 Stage III NSCLC for the Medical Oncologist
1. Refresher on T+N staging for Stage III2. Evidence for concurrent chemoradiation3. PACIFIC Trial4. Encourage cessation regardless of stage of Lung Cancer CitationsAs always, citations, and sources include...
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Season 3
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Episode 9
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27:46
03_08 ADAURA Trial
1. Background on adjuvant EGFR therapy2. Discussion of initial and updated results3. Hazard Ratios and Context4. When crossover and access limit generalizabilityCitationsAs always, citations, and sources include educ...
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Season 3
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Episode 8
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25:58
03_07 (Neo)Adjuvant NSCLC
1. Considerations with surgery, radiation, rate of relapse2. Adjuvant chemotherapy3. Adjuvant immune checkpoint inhibition4. Emerging neoadjuvant trial CitationsAs always, citations, and sources include education ...
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Season 3
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Episode 7
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24:16
03_06 Driver Mutations in Advanced NSCLC
1. EGFR inhibitors2. ALK inhibitors3. Less common molecular targets4. Role of KRAS inhibitors and evidence for sotorasib CitationsAs always, citations, and sources include education from our respective trai...
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Season 3
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Episode 6
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34:06
03_05 NSCLC metastatic without driver mutations
1. Evidence to support platinum doublets2. The tale of pemetrexed3. Immune checkpoint inhibitors alone and in combination4. Second Line, approach in progression CitationsAs always, citations, and sources in...
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Season 3
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Episode 5
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31:52
03_04 Overview of Lung Cancer
1. Presentation and Work-up2. Staging and how to memorize staging algorithms3. SVC Syndrome, an oncologic emergency4. Variations by histology and molecular mutations CitationsAs always, citations, and sourc...
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Season 3
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Episode 4
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25:14
03_03 Metastatic Melanoma
1. Patterns of recurrence and approach to stage IV disease2. Immunotherapy and BRAF/MEK considerations3. Cross trial comparisons4. Later line and emerging therapies for advanced melanoma CitationsAs always, citati...
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Season 3
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Episode 3
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36:20
03_02 Localized Melanoma
1. Background, staging and work-up of regional melanoma2. Evidence for adjuvant and neoadjuvant immunotherapy3. Adjuvant BRAF/MEK inhibitor 4. Considerations for stage IIB/IIC disease CitationsAs always, cita...
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Season 3
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Episode 2
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26:55
03_01 The era of immune checkpoint inhibitors
1. History of Immunotherapy2. Modern immune checkpoint inhibitors (ICIs)3. Unique considerations with ICIs4. Immune related adverse events and immortal time bias in observational studies CitationsAs always,...
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Season 3
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Episode 1
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22:59
02_10 BRCA Positive Breast Cancer in the Clinic
1. BRCA 1/2 genes and relation to malignancy2. Family history taking and identifying patients for genetic testing3. Risk reduction strategies for breast and ovarian cancer4. Systemic therapy considerations in BRCA positive breast ca...
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Season 2
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Episode 10
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21:39