Talking About Tumors with Ryann and Ryan - A medical oncology podcast

03_05 NSCLC metastatic without driver mutations

June 20, 2023 Talking About Tumors Season 3 Episode 5
Talking About Tumors with Ryann and Ryan - A medical oncology podcast
03_05 NSCLC metastatic without driver mutations
Show Notes


  1. Evidence to support platinum doublets
  2. The tale of pemetrexed
  3. Immune checkpoint inhibitors alone and in combination
  4. Second Line, approach in progression



As always, citations, and sources include education from our respective training programs, the Devita textbook, and  We highly encourage review of guidelines published by ASCO, ESMO and other organizations local to your practice.

DeVita, Vincent T., Jr., Theodore S. Lawrence, and Steven A. Rosenberg. Devita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. 10th edition. Philadelphia: Wolters Kluwer, 2015. Waltham, MA: Wolters Kluwer.


1.           Paz-Ares L et al.  Lancet Oncol. 2021;22(2):198-211. doi:10.1016/S1470-2045(20)30641-0

2.           Hellmann MD et al. NEJM. 2019;381(21):2020-2031. doi:10.1056/NEJMOA1910231

3.           Socinski MA et al. J Thorac Oncol. 2021;16(11):1909-1924. doi:10.1016/J.JTHO.2021.07.009

4.           Reck M et al. NEJM. 2016;375(19):1823-1833. doi:10.1056/NEJMOA1606774

5.           Paz-Ares L et al. NEJM. 2018;379(21):2040-2051. doi:10.1056/NEJMOA1810865

6.           Gandhi L et al. NEJM. 2018;378(22):2078-2092. doi:10.1056/NEJMOA1801005/

7.           Scagliotti G et al. Oncologist. 2009;14(3):253-263. doi:10.1634/THEONCOLOGIST.2008-0232

8.           Paz-Ares L et al. Lancet Oncol. 2012;13(3):247-255. doi:10.1016/S1470-2045(12)70063-3

9.           Paz-Ares LG et al. JCO. 2013;31(23):2895-2902. doi:10.1200/JCO.2012.47.1102

10.        Scagliotti GV et al. JCO. 2008;26(21):3543-3551. doi:10.1200/JCO.2007.15.0375

11.        Delbaldo C et al. JAMA. 2004;292(4):470-484. doi:10.1001/JAMA.292.4.470

12.        Ardizzoni A et al. J Natl Cancer Inst. 2007;99(11):847-857. doi:10.1093/JNCI/DJK196

13.        Temel JS et al. NEJM. 2010;363(8):733-742. doi:10.1056/NEJMOA1000678




Talking about Tumors with Ryan and Ryann is not medical advice.  We have received no funding in relation to the information discussed within this episode and have no financial conflicts of interest to disclose.  All opinions are those of whoever stated them.  We have compiled this podcast to serve as an introduction to the field of medical oncology for post-graduate trainees interested in the topic. 


Hematology/Oncology, evidence based medicine, education, chemotherapy, immunotherapy, medical oncology