GLP-1 News: New Studies, Lawsuits & Compounding

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GLP-1 News: New Studies, Lawsuits & Compounding

What do the latest GLP-1 studies actually mean for patients?

This week, Kim is joined by Maria Rising, GLP-1 advocate, creator of GLP-1 News Now, our special guest News Correspondent. After living with PCOS and surviving a stroke in her 20s, Maria became passionate about helping patients understand the science behind obesity, GLP-1 medications, and access to care.

There isn't just one new GLP-1 study every week anymore. There are dozens. Maria follows the research, policy changes, and industry news so patients don't have to. Together, Kim and Maria break down the latest headlines and explain what they actually mean for people living with obesity and metabolic disease.

In this episode:

- Maria's journey with PCOS, stroke, and GLP-1 treatment

- The latest GLP-1 studies and research

- Compounding updates and current lawsuits

- What new research means for patients

- Obesity, metabolic health, and access to care

- How to separate headlines from evidence

For ongoing GLP-1 news, research, and access updates, be sure to subscribe to Maria's Substack and TikTok.

TikTok: https://www.tiktok.com/@tirzepatidetales

Substack: https://glp1newsnow.substack.com

The Plus SideZ Podcast is an educational podcast focused on obesity, metabolic health, and GLP-1 medications. This episode is for informational purposes only and is not medical advice. Always talk with your healthcare provider about questions regarding your treatment.

Transcript

SPEAKER_03 0:01

Hey plus science community, before we jump into the podcast, do me a favor, like, subscribe, and share if you haven't already. This helps us get referred up in the algorithm so we can find more people that need our help and guidance from our doctors. Thanks so much for supporting the show. Let's jump in. Friends, the GLP1 math is just not mathing. When I look and see 104 million people in America are struggling with a disease of obesity, and about 11,500 obesity specialists, that breaks down to like one obesity specialist per 9,000 patients. I saw the stat that said 72% of GLP1 users say that they want more support on their journey. Because I think we all realize you start on these medicines and you think, oh, it's just gonna be like Venomine or anything else ever taken the past. This ain't like that, bro. Like it's just not. It's different, you know? And I provide a lot of that here by interviewing doctors and things like that. But I've had people been asking me, emailing me for years, asking me to do one-on-one consoles, which I do do, but they're expensive, right? So I decided to make a group where 10 people at a time would come in with myself and with Kat. We could talk about recipes, we could talk about exercise, we can talk about side effect management. Um, we could talk about, you know, ideas on breaking stalls or things that we've tried. None of it's medical advice, but it is community support. It costs $50. If you're interested in that, there's a link in my bio. You just fill out that form. If you're not and you just want to go this route, that's okay too. I love you. And not alone, it's not your fault. And hopefully you'll sign up to hang out with us. All right, now back to the show. Are you interested in understanding GOP1 medications, Lycosympic, Wolfie, or Manjaro? Then join us on the Plus Sides, cracking the Obesity Code, the groundbreaking podcast helping people change their lives one episode at a time. The Plus Sides podcast is Disruptor. We're breaking down barriers, smashing stereotypes, and sharing inspiring stories that'll leave you feeling enforced and empowered. Join us every week to learn from doctors who are specialists around GLP1 medications, like a specific manjaro. We'll provide you with science and facts to validate this incredible story. But that's not all. We'll also bring you the voices of the GLP1 Manjaro TikTok community, real people who face the challenges of obesity related diseases and disorders, and discover the incredible plus fives of GLP1 medications. Our episodes are filled with heartwarming stories, laughter, and moments of triumph. You'll connect with our amazing community members who are reclaiming their health and experiencing their fullest lives. Are you ready to embark on a journey of discovery and empowerment? Tune in to the plus five cracking the obesity code, and together we'll change the narrative around obesity and the stigma. Subscribe now on YouTube or your favorite podcast platform and join our incredible community. Let's celebrate the plus sides of life together because every story deserves to be heard. Every life deserves to shine, and everyone deserves access to expert knowledge and medication. The plus side podcast, you're not alone. It's not different.

SPEAKER_02 3:04

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SPEAKER_04 3:33

Good job, sir.

SPEAKER_03 3:35

Exactly. Welcome, welcome to the Plus Sides Podcast. Hey Maria, what are you doing? Hey, I'm hanging out with my best friend. I'll see you, best friends. Hi guys. So uh Kat's taking a little break, and uh I've got some new friends coming in to talk with us about some stuff. And just like I took a break, because sometimes life gets in the way, we got some things to take care of. So uh we're gonna do things a little different. But if you are new here, we'll do quick intros. And I would say this is your key to fast forward, but you know it's not because you have to listen to Maria's intro. So no fast forward for you. Okay. So hi, I'm Kim. This is the Plus Sites Podcast. This podcast is an education and advocacy podcast all about metabolic disease, treatments, what it is, all the things. It's community. We're wanting you to heal and be the like healthiest you that you can be, right? Not whatever like friggin' number somebody else has for you because all that's just bullshit. So we talk about all those things here. We bring in experts, you're gonna communities, you have resources, all the things because you want you to have a place to go. We know there's a lot of misinformation out there. Um, this podcast has been around for uh three years. I think I've probably already said in lots of awards, but I have like I have really bad, I've been titled on a lot of meetings today. So I have like the ADHD heart, you know what I'm saying? Um, but this is just a good place for you to come. And today we're gonna talk about news. Uh, sometimes we do that. I usually don't. And I I didn't want to tell you, Maria. I asked, I asked uh talking to Sabine about it. I was like, I don't like doing the news. I go, and she goes, I think it's just not your style, like your style of content's just different. So it just doesn't, it may it makes you feel uncomfortable. I was like, well, I like hearing it from you guys. I don't I don't watch regular news, I only watch the news you guys talk about. Oh, authentic and warm and real and not bullshit and not spun, like it's for us, and so it's like I don't know, for us by us news, you know. So I'm so glad to have you here to bring twos to the placades because they know I don't like to do it.

SPEAKER_04 5:26

So that's fine. I love the news. I'm obsessed with the news. News is I know I love it, I love it.

SPEAKER_03 5:32

Okay, so um tell us who you are and how you help.

SPEAKER_04 5:35

Oh hi, I'm Maria Rising. I do the Rising Health Report on TikTok, but everywhere else you might know me as Trisepatide Tales. TikTok had some funny business, and I had to change my name because Trzepatide was in it. So we did a mini rebrand, but you'll find me on Substack. I post pretty much daily, sometimes multiple times a day, depending on how hot the news is about what's going on in the world. I like policy and law and everything that's happening in the news, and I also love research. Uh, I'm a GLP1 patient myself. I've been on compounded trzepatide for two and a half years, and I come from a like medical background myself. I am not a doctor. I am not a doctor, I'm not a doctor. I do that very much. Um, but I worked in medical research. So I trained doctors how to do research. I did some of the research myself and got myself a PhD, uh, but not the kind that's useful when you're talking about medicine.

SPEAKER_03 6:32

Sad story.

SPEAKER_04 6:33

Um, yeah, so I have social media channels, I report on the news, I've worked in telehealth, I've been around compounding pharmacies, I've been around the research, and I just really like communicating and educating folks and empowering folks to take control of their own health. I've had some health scares in my life, and it really has reframed the way I think about healthcare and what I want for myself and you know the people in my community that I adore and everybody in the world, you know? Yes, that's me.

SPEAKER_03 7:01

Big heart, big brain equals Maria. Stop. That's your new tagline. You're welcome. So innovative. It was very chat G Petit. Oh my God. I love it though. So um, we're gonna we're gonna talk about some GLPT. So, like things that have been going on in the news and some studies and stuff like that, and just have a conversation. So, this isn't gonna be like weird QA stuff. We're just gonna hang out. So, we hope that you'll hang out with us if you are watching on the YouTubery right now. I'm gonna need you to hit that little like button, okay? And if you're watching anywhere else where you can comment, do that, would you? And share it and all the things because that is how we help more people, guys. That's how this algorithm works, right? They they're only sending out the people that are you know telling all the lies because it's extreme. You gotta help us out by doing all the stuff.

SPEAKER_04 7:51

We don't we don't want to become popular by saying extreme, crazy stuff. We want to become popular by saying real stuff that actually moves the needle, not crazy stuff because social media loves crazy. Hopefully, not crazy.

SPEAKER_03 8:07

I'm I'm a little more than crazy excited, but I I'm all kinds of shades of crazy, but we all know this. You've been with ever for a while. So but it's a good day. All right, so tell us what's what's fresh.

SPEAKER_04 8:20

What's fresh? So the latest news that I uh was reading about and writing about today that I'm I'm excited about. Maybe it's not that exciting. Nova Nordisk is suing Eli Lilly over advertising of Zetbound and Wagobi. How is that a thing? Right. How is it a thing? Well, if you recall, Novo and Lily have been suing compounders in telehouse like wild. There's hundreds and and actually hundreds of lawsuits in the past two years going out from big pharma to the little guys, right? Trying to say you can't advertise, you can't say essentially the same, you can't do essential copies, it's not FDA approved, like all these things that we've probably heard if you're in this GLP one ecosystem. So now they've turned their attention, those lawsuits have kind of tapered off. There's not been a lot of new ones recently. We're still trying to tie up the original ones. They turned on each other. The two major giants of GLP ones, they own, you know, 98 to 99% of the GLP one market right now. Uh, they're turning on each other. They're saying, you are making ads that make us look bad. And we want you to not only take those ads down, we want you to publish ads saying you were wrong. Like, what? That's insane. I know. I'm like, yeah, they're not doing that.

SPEAKER_03 9:40

And it's all about Man, you gotta have some giant conies to save that. Like printed attraction. That's like kind of what it is, right? That's the vibe.

SPEAKER_04 9:51

Yes, yes, it is, and it's kind of like it is the first one. It's like the first document of the lawsuit, right? The initial complaint, like Lily has not responded yet, which anxiously awaiting. You know how many notifications I set I set up this morning to see when Lily says something, I'm gonna be right there, like hot tea. Um, but it's crazy. You you shoot for the moon in your first one, usually, right? Like you can't ask for more as you continue on. So usually ask for like a lot up front. Um, but but it's good stuff. So it it still gets a little bit messier or juicy, if you will. So there's like two numbers on screen in these ads. It's like weight loss from Zeppelin, weight loss from Agobi. Yeah, and Novo is saying that Lily is cherry-picking the studies that they use for these numbers to make themselves look better. And now this is interesting, right? This gets into like data science and research and whatever. And I promise I'll try to not make it too nerdy. But essentially, what Lily did, or they're alleging Lily did, alleging was yeah. Well, I mean, it happened. Like I saw the ads, you saw the ads, like whatever. Yay was saying they allegedly allegedly. Um, so they used a trial of Lily's drug or Novo's drug Wagobi. That was before they approved a higher dose. So it was a lower dose data and it was old. It wasn't even current data, it was old against Z bounds, most current data and higher dose data. So it was like skewed, right? And so then it's it looks a little funnier. And Novo's saying, you know, if you do honest data, us now, you now, they're the same, essentially the same. That's not fair. That's not fair. Advertising that they that Lily keeps saying, we're better, we're better than Novo, we're better than Novo, we're better than Novo, we're better than Novo. That's the undertone of all this advertising. And Novo's like, are you though? And then they go on to poo-poo on the research and they say, actually, we think your clinical trials weren't very rigorous. And rigorous is a word we use in research, basically saying like good, high quality. Yeah, like they're they were very rigorous. So, like, honestly, do we trust any of the numbers? And I was like, okay, oh my god.

SPEAKER_03 12:21

Jeez, whoo! I mean, like, I can't know, but like, but is it okay? So they're getting sued, but it's it's not illegal to do this, right?

SPEAKER_04 12:34

Well, misinformation is quasi-illegal. Yeah, quasi slander isn't isn't nice. I don't think they called it slander. It's called false, it's false advertising, it's land act lawsuit, yeah. Because like it is a misconstruing of the truth, right? Like we talk a lot about like disclosures with pharmaceutical advertising, right? Like, there has to be lots of disclosures because you know, the really fast low voice at the end of every pharmaceutical advertisement you see of like side effects may include blah blah blah. Um, like those have to happen. But then we are starting to get more deeper into these things of like we need to talk about the pros and the cons. You can't just list the side effects really quickly at the end. You have to be like more honest in marketing. And that's like a movement with our government that we're trying to like push for, like more honest pharmaceutical uh advertising, which we love that because we're subjected to so much more advertising these days with social medias and the internet. Yeah, but they're still figuring it out, but also like lawsuits are now like ensuing a little bit more, I think, because there's more opportunities for stuff to have just like trying to have like a higher standard, like or something in this area. Yeah, absolutely. I mean, let's let's get really real with this. Eli Lilly was the seventh, so I think it was the seventh. Don't you know, fact check me on that one. But they were the seventh company in the world to reach a one trillion dollar evaluation. That's trillion with a T.

SPEAKER_03 14:00

Only the seventh.

SPEAKER_04 14:01

Yeah, there's not many. Like NVIDIA just got on it, Lily got on it right after NVIDIA. I don't even understand what trillion means. What does it even look like? I don't even understand what a million looks like, let alone a million millions.

SPEAKER_00 14:20

Insane.

SPEAKER_04 14:22

But like they reached that evaluation, meaning the company itself was worth that amount of money. They're not saying they made a trillion dollars, they're saying that the company is worth one trillion dollars, which means they've made well over that.

SPEAKER_00 14:33

Yeah.

SPEAKER_04 14:34

And like that is concerning, right? When some competitor, their their biggest competitor is Nova Nordisk in the GLP1 space. Their competitor's saying, like, you're cheating, essentially. How fair is that? You know, like that, this is where we start getting into all of that.

SPEAKER_03 14:51

Well, because yeah, because like when this one thing I had someone on my show recently. I won't go into the whole thing. Um, but they I don't know, I don't know if I say this. I know someone that told me, you know, I only take the Kim go back and edit this. I I know someone that said to me, Hey Kim, you know, I take Ozempic, um, but I don't take the weight loss doses. I just take the ones to control my blood sugar. But ultimately, that's a misconception because it is the same medicine and they are all weight loss doses, and they are all blood sugar controlled doses, and it just depends on the person. But that is why does that miss like why isn't that not clear? And it's because of things like this, right? It's because of this. Let's brand this over here to be the weight loss one, and let's rebrand this over here to be the diabetic one, and and and let's call them weight loss. Oh, wagobi and ozembic, like what's the difference? Yeah, dose. Like, you know what I mean? Like, that's it, right? But and honestly, and it's not, and the dose doesn't even start to change, right? Because, like, with just so everybody knows, if you guys don't know, because I don't think a lot of people do, so like Ozimpic and Wagovi are the same medicine that like I I'm without I'm I'm throwing down the is the same, okay? And Manjaro and Zetbound. We'll throw that one out there too. The difference between Major and Zetbound being exactly the same, though, is that they're not dose different, like they're the same. Same and same dose, it's got a different template on it, okay? But Osimpic and Wagovi, the misconception there, and they also did this with the daily one, which was Victosa um and sexenda, right? That it's it vary by it varies by dose. So for like back to like Ozimpic and Wagovi. So um Osimpic goes up to two milligrams, right? And then Wagovie goes to 2.4, but they just got approval for the higher doses. I can't even remember when that was. I knew they were studying it like a couple years ago. And so then now now it's available, and then they have the pill outs, right? So that still is all fairly new, like I think in medical stuff, right? So it is difficult as a marketer, right, to be like, oh, well, now I gotta go back and change my this and this, you know, like you're gonna use stuff that's in market, I would think, right? Or that's come to market. And I don't know if when they had done that. That's what I'd argue if I was their attorney. Like, did is this just data they knew about it, or is this data that was published? Was this actually available in market? Because if it wasn't available in market, it was available in market. Okay, the high doses were okay.

SPEAKER_04 17:11

It was right around, so they uh so they started them a season assist. Season assist, and then they did they just were like, Yeah, how we're gonna keep on publishing. Oh and that's when the lawsuit came. Oh, is it really? Yeah, I think they gave them a little bit of a warning that they were like kind of pissed about it. It wasn't just like we're really pissed, it was like, hey, we're mad, we're really mad, we're really mad.

SPEAKER_03 17:33

Oh, okay. Yeah, I mean, because if you think about it, like the and I I see this a lot in our community because everybody was like so stoked about terzepatine, and there are people asking all the time which one is the best, and most of us will say whichever one you can afford, right? And then that works good for you because I lost I literally lost all of my weight on Novo Meds, and the regain that I've experienced was what I lost on the Lily Meds. Like it's just to it, it's just your buddy, it's just like whatever you respond on you can afford, right? Like, but I think that like we look at these like statistics, right, and the study data, but like when I was I talked to one of our doctors, and she was like, you know, if you look back at how they're doing the the sort of like 72-week one, and then they're looking at the trial, that's you know, gonna be better than this than I will. And then she was looking back at like the the one where you like over three years they're tracking, right? And she's like, on average, it was like 55 pounds. So that means some people may have lost a hundred, right? And some people might so we're looking at these and we were making these like generalizations, but we've all seen when they rolled this out in market, some people were wildly more successful, and some people were not successful at all. And I think that's how averages work, yeah. Yes, but I don't, but I think that that people don't think of it that way, and a lot of it is because of the way things are advertised, you know.

SPEAKER_04 18:50

It is like advertising is manipulation, right? Like advertising is getting you to think the way that we want you to think, and then behavior follows that, right? I mean, like Kim, you're a marketer, but like that's my you know, spark notes on that. But I I wanna I want to get on a high horse really quick because you like spark something in my memory. I hate it when people say what's the best or what's good. Yeah, because what does that actually mean? How you define good and best are so different than me. And like we need to be more specific when we're saying, like, is it good or is it whatever? Like, is the best price? Does it have at least side effects? Um, does it do whatever? Like, we need to define good and best because they they're just low impact words because there's just so many ways you can define them. Like I remember this in a speech class that I did in grad school, like saying good is useless. Yeah, it's just like it's not a it's not a word that causes impact or power because we don't know what good is. Good is evaluated off of your own internal standards. So when you're trying to communicate with anyone other than yourself, good doesn't matter. Yes, and it's just like I hate when we hear good and best as descriptors because it's different. And when I'm like, oh, what's the best GLP one for Maria?

SPEAKER_00 20:09

Yeah.

SPEAKER_04 20:10

I I I like trusepatite with B12. I'm naturally deficient with B12 and have and I have been deficient my entire life before this all started. So like I like that and I like trusepatite. I have like the best, likely side effects with it. That's what I like. And I just answered you with like why it's good for me. It's because of the side effects and the B12. Yeah, it's not because like I lost the most weight, it's not any of that. But like you might say those aren't aren't the important things for me. So true.

SPEAKER_03 20:41

Yeah, I think like I think it would be too um some, but I think when people come in, they're like on our lives, for example, they're like, which one they're about to make the decision, which one should I get? Which one's the best? Because they make the assumption that because one is less expensive than the other, then that must not be as good. And that goes back to the whole really all the things we're talking about here in the advertising practices, right? Because forever we didn't could anybody help any understand GOP1, GIP, or anything. Everything was Ozimpic, and everything was people, all the fad people are taking Ozimpic and taking it away from the diabetics. That was the narrative for like two fucking years, man. Like it was the worst, you know, and we're like, they are the same thing. Like, and the reason that they help people with obesity is because it's the same underlying biological dysfunction. But that's not I I wish they would do that in advertising, honestly. With I like like free okay, I know lonely people watch my show, guys. Free advice, find a way in your advertising to educate people, and you will sell empower them, empower people with knowledge. That's all you need to do. Did you know is a fucking disease? That's what you need to say, and then be like, direct how it works. You know what I'm saying? I'm just saying I built the entire platform of doing nothing, but taking all of y'all's baloney and breaking it down into what people can understand. Yes, fix that, would you? We'd like that a lot.

SPEAKER_04 22:03

I think they should fix it. Well, and and that that is the thing, like that it kind of sucks. Like you've built such a like great platform and like everything, but like we incentivize like this directedness of like not only extremism, but like do steps one through four and you will get this. Yeah, nothing, almost nothing in reality works that way. But we're so fed that through advertising and social media that we're so trained to it. When somebody says make your own decisions, we're not used to that. Yeah, let's go back to that. Like, that's what my whole thing goes by. I love teaching people research and I love teaching people the news because I want to give it to you in bite-sized snippets that you understand.

SPEAKER_03 22:42

You get a little of Maria's opinion because, like, I honestly tell myself, but well, yeah, you go get it, you get to make your own decisions just because you have bias and opinion, it does not make you a bad person. You just have to recognize it and be like, Okay, this is my opinion. I want to check with someone else. That's it, you know?

SPEAKER_04 22:57

Yeah, that's it. If you read my Substack articles, usually the last paragraph or two paragraph is like what Maria thinks.

SPEAKER_03 23:05

Yes, quick book. I'm gonna put it in there. Substack. If you guys are readers, okay, you gotta go over there, click on it, especially my listeners of podcasts, because I know you're readers, okay? Go over there, check it out. Okay, best quick, all right. Back in London.

SPEAKER_04 23:17

I well, hold on. I'm gonna add one more. Did you know on Substack you can listen to articles now too? Because I drive a lot and I like to listen to things. Um, and I do a lot of gardening and I listen to it. Can you put them in a queue?

SPEAKER_03 23:29

Because that would be ideal.

SPEAKER_04 23:30

I don't know if you can put them in a queue, but if you scroll either to the top or the bottom of the article, there's a little like triangle thing and you can listen. And it's super helpful because I'm more of a listener than a reader these days. So, like, yeah.

SPEAKER_03 23:42

All right, I'm pretty sure Substack needs to realize that if they just had a podcast, like if it was if it everything was in there like a podcast, people would just do what I mean.

SPEAKER_04 23:52

Okay, action item for us, Kim, for the future. Um solving everybody else's problems and not charging. No, but there is a podcast option on Substack, but I've never posted to it because I don't have like a podcast. Was there my podcast? Well, it's RSS.

SPEAKER_03 24:06

Okay, it's RSS. But if you could there's a way that you could like, there's gotta be. I'm listening Substack, I'm gonna need you to figure that out because our people that like to listen also like to read.

SPEAKER_01 24:15

So that's true.

SPEAKER_04 24:16

Like, I like to fact check things, right? Like I like pictures also. Like again, my Substacks primarily research. Sometimes they have really awesome graphics, and it's like really good to see what they're talking about and like understand it a little bit better.

SPEAKER_03 24:30

Yeah, for sure. Love it, love it. So, yeah, okay. Tell us in the comments while you're listening. Do you think because I've heard people say I don't want them advertising meds at all? I think that's problematic because I don't trust. I'm sorry, I just don't, I and you guys know a lot of these doctors are so my friends, right? I don't trust that they have the ability to tell me every time a new med comes out and that I'm in their office and that they know what's right for me. Like that, I uh they don't have, I don't think they have the time or the ability to do that. And if and the time that that we miss taking these meds when we could have been healthier a lot longer ago, I a lot of that I think is because we didn't know and because they weren't talking to us about it. And there's lots of issues and lots of science and stuff that's involved and all that of the bias and medicine and stuff. But regardless, I don't want to not, I don't want any more cut-off information from me about something that might help me. And I'm fine to be the person that goes to my doctor and talks to them and annoys them about it. I don't have a problem with that.

SPEAKER_04 25:24

So I think we're teaching people to have autonomy. Like our doctors, unfortunately, have been like behavior modified by the insurance companies and the whole process of our current healthcare system, right? Yes, they can't talk to us for like hours a day, they can't research the charts for hours, like they they just can't. They're allotted 15 to 20 minutes per patient, and they gotta have you know 50 patients a day or whatever the number is for their practice. Yeah, so you have to come to them kind of ready to go. And like that's what I've found out with GLP1s. And I had a stroke previously in my 20s, and a lot of it was really advocating for myself.

SPEAKER_03 26:02

Like, and that's even though when you were in your 20s having a stroke where they bully you off.

SPEAKER_04 26:07

I got discharged.

SPEAKER_03 26:08

Oh my god.

SPEAKER_04 26:09

I went to the ER, like the droopy face. I can't do it on command, but droopy face, could not talk, couldn't stay conscious. Like I was coming in and out of consciousness, and they sat me in the ER for four hours, and then a nurse carried me out, put me on the curb, and said, You probably just need to go to sleep. And I didn't have a phone, I wasn't talking. I a random stranger took me home. Like, I'm very lucky I wasn't kidnapped, but uh, like took me home and I like laid in bed, and then the next day my friend came over and she's like, There's something wrong. And I was like, Yeah, I think I have migraines, chronic migraines. She's like, Maybe you have like a really, really, really bad migraine. She calls my neurologist. We go over there the same day, and he's like, You're having a stroke. Like, go, you need like this is a stroke, go get an MRI. So we get an MRI. Before we even get home, the radiologist is like, You're having a stroke, but we can't give you uh it was TPA's back then, it's a clot busting agent because it had been over 24 hours, like it'd been a long time.

SPEAKER_03 27:10

Look, sorry, Dad.

SPEAKER_04 27:11

And so I didn't get any of that, and then I'm just like advocating and re-avocating, and they're like, Well, it's just a fluke, it's a fluke that a 27-year-old, pretty dang healthy girl had a stroke, and they're like, just live with it. I tell you what, I couldn't live with it. So, like, that's where I I'm I that's where I come from. I guess my background, I just gave you a lot more information than y'all need to know. No, no, not on this show.

SPEAKER_03 27:36

Not on this show. You think, you think, no, no, no, I'll get it out of you. No, I think that that's and I think this is another example, though, of why it's important to make sure that and I I know we have so much information, it's hard to be able to weed through it and like know what's actually important anymore. I get it. I'm on totally on the team of I don't know what to believe anymore. I get it. But there are certain things, especially around health, because there are not enough doctors or not enough experts or not enough whatever to be able to get us what we need, right? And we always think that we're not the nuance or that we are, like, you know what I mean? Like, you know, and I think that we have to find a way to be able to like watch shows like this, right? Like watch TikToks and stuff and be able to know these things because I promise you, those knowledgeable things have been able, people have been able to advocate and save their lives, right? Like that's it's so important. Like my sister, I'll be my sister was young and trim and beautiful and everything, and she was going to the doctor with all this tummy stuff for years and years and years and years and always blown off because she looked young and trim and beautiful, and she had a autoimmune disease. And we didn't know until it was already attacking the bile duct in her liver. Sorry for the thumbs up thing, you know what I mean? So it's like I think that we have to quit dismissing people because they're fat, dismissing people because they're old, dismissing people because they're young. Like, and I think that those pieces, it's not like I don't think it's part of the story, but it shouldn't be like the filter, right? And now we're just done we dismiss it, you know. So I think that's all really important. And that's why I think more information, just better information, is what we need to focus on. But I'd love to know what you guys think about that in terms of advertisements. You know, please tell us in the comments.

SPEAKER_04 29:14

But I want to share, I want to share one more story because like triggered us. Um so the whole idea of like, you know, having autonomy, but like also sharing, right? Like sharing is good. We like learn from talking to each other. We don't have to take every single word that is said to us as like the gospel, but we listen and we like meditate on it a little bit. Um, so my father-in-law Dave just had a second stroke about a month ago. Oh fuck. And it's horrible. Stroke is horrible. If I can like get rid of one thing, cardiovascular disease, like hate it. But GLP ones help with that, so we love them. But um, so Dave had a stroke and it was second one in five years, and I was really scared. Like he was full facial droop. It was worse than the first one. He couldn't talk, he couldn't walk, he was very incapacitated. Got him to the hospital within an hour. We got given something called TNK, it's just like the TPA that I was supposed to get, but it it's like Drenal for your brain, and it like specifically targets the clot and like busts it up. 15 minutes later, he's talking and walking again. It was insane. It was a literal miracle. I know they call Zimbek the miracle drug. No, yeah. Nope. TNK is. I saw it. I saw with my own eyes. But I'm very emotional about this. I made a TikTok post about how I've had a stroke, he had a stroke. Yeah. And talking about the acronym B Fast. Get people to the ER. Even if you don't know, you have a four-hour window and it can change a life, save a life.

SPEAKER_03 30:43

Can you since I mean, because you just never who's gonna help, can you can you do it right now? The BFAT. Can I do it? Can you tell us?

SPEAKER_04 30:49

Oh I'm I'm blanking out of like pure, just like fast. Okay, it's just hold on, hold on. I can I got it, I got it, I got it. Okay, so B fast.

SPEAKER_00 31:01

Yeah.

SPEAKER_04 31:02

An acronym of what to look for when you need to go to the hospital. So B is loss of balance. So like you get disoriented, like the ear stuff and head stuff, it all changes that. Any changes in your eyes, the E of B is if your eyes change. For me, I had like quadruple vision. Like there were like a bunch of different things for him. For me, he was just dizzy. He didn't have a lot of vision changes. Face droop. So like you ask somebody to smile or say some phrase usually doesn't sound right. And then we have arm weakness. Usually one side will be weak, or you don't want to like lift your arm up evenly, or you can't hold your arm up, it just kind of naturally falls down. Okay. Um, speech difficulty, slurred speech, whatever. T stands for it's time, it's time to call 911. Wow. So many people have these symptoms and just think, I'm gonna go to sleep and then I'll be better in the morning. And some of those people don't wake up, and some of those people wake up with big detriments that could have been reversed with this TNK, like I was taught.

SPEAKER_03 32:00

Right. Like being able to go to the ER and get down medicine and stop the issue, right?

SPEAKER_04 32:05

It is a hard four hours. It's a four hours from onset of symptoms, not four hours from when you notice them. And sometimes because you are cognitively impaired with a stroke, you don't realize that these are happening. So Dave didn't know that he was having this stroke. He was mowing the grass when this was happening, and he mowed the grass for like 15 more minutes before he came in the house. He didn't know he was having a stroke until he looked in the mirror and smiled and noticed that it looked weird.

SPEAKER_00 32:32

Yeah.

SPEAKER_04 32:33

He didn't know before then, and he couldn't do like a bunch of stuff too, but he he wasn't like cognitively there to like know this. Um, so I think that's also important to know about this. Like, it's like when you first start getting drunk, right? You don't know you're getting drunk because it's like part of the action of alcohol in your system, is like not being aware. Um, it's the same thing. Um, so back to my story. I've made this TikTok video, and it's very like, I just feel bad. I want everybody to know. My friend Natty, who owns a company called SHAPA, he's wonderful. If you know what Shapa is, I highly support them. Calls me up and says, Maria, I had a recent scare, and we found out it was something called lipoprotein A that caused it. You should have your father-in-law test it because we went through a slew of testing. We stayed in the hospital for over a week. I think we did every test that the hospital had to offer essentially and found nothing. And they were just like, Go home. And we were like, No, this is the second one. Like, no, like no, we love him. We love him. We don't want him to like have, you know. Um, so Naddie calls me, tells me that I call him, he calls a doctor, they go in the next day, it's a blood draw, uh, but not a standard blood draw. It's similar to LDL and cholesterol, it's a form of cholesterol that is like more genetically inherited and doesn't really change with statins. Um, but it's a silent killer. One in five people have high lipoprotein A. It causes strokes. His was five times what the max level was. So we as soon as we got that result back, the doctor's like, yeah, that was it. And we said, Well, why didn't we test for that? And they're like, Wait, it's not standard here. But but what and then they're like, Well, we don't even have anything to give you or to do about it. But next year there'll be an FDA-approved drug that will like be ready for this. But like right now, we can't do anything. So, Maria, keyboard warrior that she is, got on the whole internet and found out that it happens in Europe as a standard practice. There's there's drugs in Europe, it happens in Canada. We just aren't testing for it and doing anything for it because like there's not a drug yet. But the moral of this story goes back to like just being interconnected, right? Like, if I hadn't made that video, Natty would have never seen it. We would have never tested him for that, and we would have never found out because it's not a standard practice of care.

SPEAKER_03 34:48

That's crazy. You know what I was thinking when you were saying that too is that like how long we have all had insulin resistance, usually before we get in that pre-diabetic and diabetic area, but they're not checking for that, right? They're not there. The and I think that that's also the same kind of the the treatment is like the same, like, but they're that they're not treating it until it's crossed over. So it's like it's the it those the standard like blood tests. And I think a lot of people do want to be empowered. Like, what do I need to check for? You know what I mean? Like, that's important, I think, because I think that doctors, I I suspect this is true. Don't say me, it may not be true, but I suspect that doctors like try to only order the blood work that's gonna get paid for by the insurance and not cause flags. I I don't know if that's true, my doctor friend. You guys let me know. But um, I don't know, but but I think that like there there has to be a reason why we don't just like do it all, you know. I can't.

SPEAKER_04 35:40

Yes, there has to be, and I I do think it's insurance as well. There's actually an article coming out of my Substack in a couple weeks about uh insurance trying to like actually make it really difficult to get GLP1s approved, like branded GLP ones approach, they put a few extra jumps in the way because at every jump people fall off and then they don't pay.

SPEAKER_03 36:03

Yes, so which is silly, and I think so too. I think they're gonna do we're gonna see more with step therapy. People are Christian, we'll go V pill, you know, and I think they'll do more with that. Um, and then honestly, depending on LG, I think that that we're gonna see that, and I agree. I think they try to rush you up in dose because they're like, that's what the study data does, because they know you'll get sick and you'll probably quit. Sorry, this is all my opinion, don't sue me. I probably can't. I'm just saying in general, this is probably what I think is happening. I'm not saying you're doing it specifically. Okay, bye. But I mean it's it does seem like that, like it's constant hurdles, you know, and it's just so ridiculous. Absolutely ridiculous.

SPEAKER_04 36:43

It is all like minutia when you just talk about it and you're like, oh, healthcare is falling apart. It hurts your soul when it's a face and a human that you know and you love, like it hurts and it's not fair because like all of this is always presented as numbers, but like every single number is like a human being, a person with a family, a person with a job, a person with a community, a person with thoughts, feelings, and emotions. Like, yeah, a lot of healthcare I feel is de-like humanized.

SPEAKER_03 37:13

Yeah, I almost feel like that has to be like well, my sister made a video about that recently. She's like, You have to almost be a little bit like a science experiment for them for them to be able to survive up here. It almost has to be that way, is what she was saying. And so she understood it because she has been the one experimented on because she had all this rare stuff, you know what I mean? And I think that's true. And I think because we look at these averages and they're the most part, you know, there's all these nuances because we're all incredibly unique, you know, and complicated, very complicated, very complicated. Yes, that's why that's like the whole idea of like even just like having a diet book that says follow this diet and you'll lose weight, you know, and you know, you'll lose this much and stuff like that. I'm like, what are you doing?

SPEAKER_04 37:54

No, because none of it, the conditions aren't the same. Like, we think about experiments, like go back to high school biology. Yes, think about all the variables you have to control for. We're not controlling for like even half the variables that are out there because like stress is a variable, sleep is a variable, temperature is a variable, all of this is a variable. Like we're all in a different body experiencing different things, and so like saying averages doesn't account for any of that.

SPEAKER_03 38:18

Yeah, I agree. It's so difficult. Like I whenever I make whenever I make like videos, I'm always like, on average, this, this, and I'll go, but I have seen this. Like this, yeah, you know, and why? So that they can go, okay, maybe that's something I ask about, right? And so I think that's it's so hard to be able to cover all of it. I also think that's why we don't we see a lot of doctors that don't do long videos and stuff, because there's just so much nuance when it comes to human beings and the human body, you know what I mean?

SPEAKER_04 38:44

Yeah, and and you just get kind of down the rabbit hole because you're like, oh yeah, yeah, this one thing, but this one thing is connected to this other thing, but it's also connected to this thing that's also connected to this thing, but this thing and this thing are also connected too.

SPEAKER_03 38:55

And then there's also this other random thing way over the you know, yeah, like and you know what happens when that happens? You start a podcast or a substack so that we can do it. You gotta you gotta talk about how it's connected, you know? But okay, I went way off. So did I, that was my thought. No, no, no, it's all important, it's all important, yeah.

SPEAKER_04 39:15

Okay, let's talk about some unique and interesting and exciting research that I just read. Um, it's about Mars and GLP1s.

SPEAKER_03 39:24

Friends, the GLP1 math is just not mathing. When I look and see 104 million people in America are struggling with a disease of obesity, and about 11,500 obesity specialists, that breaks down to like one obesity specialist per 9,000 patients. I saw the stat that said 72% of GLP1 users say that they want more support on their journey. Because I think we all realize you start on these medicines and you think, oh, it's just gonna be like Venomine or anything else or taking the past. This ain't like that, bro. Like it's not. It's different, you know? And I provide a lot of that here by interviewing doctors and things like that. But I have had people been asking me, emailing me for years, asking me to do one-on-one consults, which I do do, but they're expensive, right? So I decided to make a group where 10 people at a time would come in with myself and with Kat. We could talk about recipes, we could talk about exercise, we can talk about side effect management. Um, we could talk about, you know, ideas on breaking stalls or things that we've tried. None of it's medical advice, but it is community support. It costs $50. If you're interested in that, there's a link in my bio. You just fill out that form. If you're not and you just want to go this route, that's okay too. I love you. You're not alone, it's not your fault. And hopefully you'll sign up to hang out with us. All right, now back to the show. Okay. Any guesses of what this could be about? I don't know. The I you know, the only thing I know about Mars anything is that I remember I've been watching Big Bang with my husband, Big Bang Theory. Oh, yeah. And you know, Sheldon wanted to go there, and then he convinced Amy to go too, so that their children would be Martians. Yeah. And that's all I know about Mars. So what do you and you know, Mars bars, of course. Yeah. But what else you got?

SPEAKER_04 41:05

Right, right, right, right. I like sci-fi books. That's my favorite genre of books. So I I definitely like the space stuff. And when one popped up that was like funded by NASA and like so interesting, I love it. Um, it is about when we go on a Mars trip in a rocket ship. Not we, uh I'm not on that rocket ship. I'm not like Sheldon. Um, but when the astronauts do the sheld is not like Sheldon. Yeah, no, but we go to Mars, it takes three years to get to Mars. And there are no supplies at Mars. Like they don't have a pharmacy, a Walmart, a McDonald's, yeah, nothing. So they're talking about what astronauts might need on the adventure to bear and back from Mars. Peptides came up, so it's not just Yellow ones, it's peptides. And this is where it gets like real interesting, right? Like, so there were like a slew of peptides that they were like, we should have for astronauts because the effects of zero gravity are are big on the human body. Like it turns out humans weren't designed to be in zero gravity. It's crazy, I know. Right, it's shocking. Um, they lose a lot of, they have poor circulation issues. Bone density is actually one of the bigger issues with astronauts. Um, you lose bone density like extremely quickly in space. And so a six plus year mission would cause like detrimental density loss. So they'd have to try to like fight that. And most of the peptides that they did look at the top tier most important peptides they said in this study um were for bone density, and that they wanted to do these. But here is another bump or hurdle I'll throw out to you. When we're in Earth, we have the oozone layer and air and all the sorts of different stuff to eat up any other like ionizing radiation, like little particles that cause radiation, they tear up your cells. They're not good for your DNA. When you're in space, you don't have that. You have a rocket ship, but that stuff can cross through metal. So a lot of stuff gets ionized when it's in space. So astronauts are exposed to a lot of radiation. If you take drugs, aka peptides to space, they will be ionized. So they need to make the peptides as they need them in space. No, this is where it gets milder. Let me just like keep taking you on the crazier. Where are we going? A lot of that this part just cracks me up. Keep going. So they're using bacillus bacteria, like similar bacteria to what's in your probiotic. And those little bacteria are little peptide plants, basically. Like they'll have specific bacteria or specific peptides that they can use those bacteria to create them, culture them, use them. Crazy. And GLP1, so G Symagli. Semaglutide was on the list. It was like a mid-tier one when because they were ranking these peptides and like how important they would be. Semaglutide was on there because of its cardiovascular effects. Like it has cardiovascular protection on there. And that's another part of like spaced flight is poor circulation. We're designed with all these valves that look like this in our body, so blood flows through and it can't like back or like this. Like this. I think physics is not my strong suit, but it's so they can't backflow. Yeah. When you're in space, you don't have anything like pushing backflow. So there's like more freeform, and these like little valves push things higher in your body so they get a lot of head swelling, you get a lot of heart swelling. Uh, and this GLP1 smagalotide is supposed to help with some of that, hypothetically. We obviously have not sent astronauts to space on GLP1s yet. Maybe we have. Honestly, I don't know if any of the astronauts have been on it, but like we're not intentionally dosing them in space. Yeah, that we know of, right, exactly. But just to recap, they're gonna make uh peptides with bacteria on a mission to Mars.

SPEAKER_00 45:06

Gosh.

SPEAKER_04 45:20

This is a published research article. This is a peer-reviewed, published research article. This has been discussed, investigated, and tested. Not tested in the sense that they went to Mars, but tested in the zero theory. Yeah.

SPEAKER_03 45:36

Yeah. Like sanity. Like the Big Bang people do, they test theories, yeah, like that. Yeah, you got it. You got it.

SPEAKER_04 45:44

Everything comes out. You got it. It does. It's a good show. But that that's my wild one that I I really did kind of like go, oh my god. And same reaction to you. I was like, we are not new anymore. We are like fully arriving. Of like, what can we do with these? How can we make them?

SPEAKER_03 46:04

Like, what can I and in all fairness too? I do think we we need to probably but figuring out why why we need them so much to begin with, too. Like, I I hope somebody's like being like, all right, so we're clearly in this shit show, like our bodies are fucked up, and we have to put this in them. Can we can we just try to dissect all the things that maybe got us here? Because the only thing I ever hear is food. It's the food. It's always food. Yeah, it's always the food, all the thing. And don't get me wrong, uh the food is trash. Like it's straight trash. Okay, but there's other things, like, and I want to know what those are. And I want to know, okay, fine, is it the food? What's in the food? And once we know what's in the food, is it gonna fix if we take it out of the food? We gotta put something else in the food. Like, I want more information on what the fuck's wrong.

SPEAKER_04 46:50

But Kim, let me like push back. We just talked about how complicated this all is. Is it we're too stressed, we're not moving enough, we're not foraging for um food. Like, that's true. I mean, like everything's changed, right? Like it could be a combination of all that, right? It could be like five percent of this and ten percent of this, and like yeah, climate change, whatever, let's throw out all the things.

SPEAKER_03 47:09

Like, you can wonder, are we like here's my here's where I'm going with it? Cause because I'm also kind of spacing early too. At some point, are we gonna be at the point where we know we're all fucked up? Because you know, I don't know, I I I had diet type 2 diabetes, and my kid was swimming around in insulin, and so he's probably gonna have insulin and or be a diabetic or have obesity or whatever it is, right? So, what point do we give him medicine so that never happens? Like, I mean, simple if somebody could like somebody needs to be doing some research about that.

SPEAKER_04 47:36

Oh, Tim, hold on, I know about some of this research. So they're talking you do. I love it. So uh a lot of people are talking about ozembic babies, right? Getting on GLP one's they ovulate more regularly and then they're able to get pregnant, so it helps with fertility. Yep, hit my sub stack, there's a lot of pregnancy stuff coming up. Um so you're supposed to withdraw uh GLP1 use before you try to get pregnant. Two months for Ozambic, and I think it's three actually for Zip One. Uh people don't because they're like I'm irregular, whatever, never been able to get pregnant, and then all of a sudden they're like, I'm pregnant. And so there are like cases where babies are exposed. And now we're starting to ask the question of like, what does that mean? Um gestational diabetes is huge, huge. Like, this is a thing that happens. Um, they do treat with some different uh GLP1s occasionally. So now we're trying to figure out if we should continue use, taper use, stop use, change use, do whatever because they're seeing what they call transgenerational effects. So if a mother can control her glucose or a variety of other different things, it affects the way the genes are expressed in the fetus and the fetus's child. So it can skip generations.

SPEAKER_03 49:06

Would you say before? Like it's not something that can like I guess what I'm curious about. Like, is this something that's like preconception, right? Or is it like you know what I mean? Like, I that's what I'm wondering.

SPEAKER_04 49:16

Like, is it like okay, let's give it to them now that there's said baby, or well, so you think this is so my background is in repro. I should say that I went to grad school for repro. So this is like very like I love this part.

SPEAKER_03 49:29

Um well, all the pieces girls coming out here, so yeah, yes.

SPEAKER_04 49:35

Um, so this is like my analogy for folks when I talk about fertility, is that boys have a really great time, right? Like they can smoke and drink and party and do crazy stuff because their stem cells replenish every day, every couple of days. So it's kind of like a constant refresh, right? Like sperm are new. Like they have active stem cells that produce sperm constantly. Yeah, we are born with every single egg that we will ever have, yeah, as a woman. So everything you've done from day zero to day 1,336 plus affects the oceans that are in your body or the eggs that are in your body. So, like, you think about like how that makes me think about healthcare differently because you're like, I don't want to smoke and drink because like I got some, I got some eggs in there, like you know, and so then we talk about like there's a lot of studies about heavy metals with this, like um people who live in coastal cities and more remote countries, obviously not here, eat a lot of fish and mercury and cadmium or in fish, and they're seeing transgenerational effects again because of these metals that are affecting up to seven generations down the line. Seven generations, and and we're not talking like you know, growing six fingers, we're talking about like the expression of genes. It's called epigenetics. So you have like the DNA spiral, and then the apigenetics like sit on top of it and express it. Like that was a bad hand gesture. Um but but uh hindsight's 2020. Uh but yeah, it's really interesting, right? Because like we we also don't know what effect means. We know like it changes expression, it changes what's called methylation, which is another big sciencey word. Um, but it makes you ask questions, right? We go back to the GLP1s. Like, I chose to start a GLP1 later in my life. We don't have children, we want to have children. So then I I I personally am living this out right now of like, do I stop, do I stay, whatever? There's new, new, new, new research, like this week new um, about um people who were on GLP1 stopping GLP1s withdrawing with appropriate time and then regaining like a ton of weight.

SPEAKER_00 51:47

Yeah.

SPEAKER_04 51:48

During pregnancy plus, though, they were regaining almost double what people not regaining, I should say that they were gaining double what people normally gain during pregnancy.

SPEAKER_00 51:57

Wow.

SPEAKER_04 51:58

And they had a higher risk of gestational diabetes because of the cold turkey style like withdrawal that they did. Yeah. Um, so now the question becomes, what do you do? Right.

unknown 52:08

Yeah.

SPEAKER_04 52:08

And we're learning in live time because like we can't we can't do research where we like give pregnant women GLP1s and wash them like we do in a clinical trial. Like we have to do retroactive studies where we look at case files where things have happened and they are similar, but not the exact same commit conditions like a clinical trial. So the research like divulges differently with this kind of stuff too, and it takes like real things happening to real people, which is also scary.

SPEAKER_03 52:35

Yeah, I know, I know it is, and I I I think this is a another reason, just like to be honest, like just sitting here and listening to all this. There's so much stuff that we know, but there's way more that we don't. And I think that sometimes we forget that, and so we kind of get on these meds and we think it's said it and forget it, and then we're not gonna have to revisit it and we're not gonna have to do this, and it's just not true. It's just not for most people, it's not okay. And so I think like when when we see these things, this is why, right? People are like, fuck it. Sorry, mom and dad. Um, I'm just gonna go gray market because they don't know what the fuck you're talking about.

SPEAKER_04 53:08

Like, you know I'm well if nobody knows, it doesn't matter, right?

SPEAKER_03 53:11

Yeah, like and like that's what our brains do, you know what I mean? It's like whatever, like I'm tired of being sick, whatever. Like, I think that that happens a lot because of all of this, and so it would be better if they could like tell people what studies are going on or something.

SPEAKER_04 53:27

There's a website called clinicaltrials.org that tells you whatever clinical trial, every chinical clinical trial that's going on in the world. Wow, it's a lot of minutiae. Go crazy. Um, but you can at least know that would be an excellent Substack series article today. It's like they're coming up, there's a whole list. I'll tell you what, Cam, like this is also funny. Like, I I didn't do Substack initially. Like, TikTok is my medium, my mode. I love TikTok, it's my favorite, even though we have a love hate relationship. Um I posted a lot of research on TikTok, and I started doing this whole research angle because it like PhD Maria and you know, extrovert Maria got married and just like love it. Um like two years ago, honestly, I started doing this. I read research every single day, and I was doing a lot more medical research at the time, so I was really diving in that deeply. I was so excited when there was like one paper a week that would mention GLP once that weren't lyroglutide. Lyroglutide's been in like the it's longer. I I wanted to know about semaglutide and truseptide. I really wanted to know about triseptide. And I would get so excited, it'd be like one a week, and I would get so excited, and I would print it and I would highlight it, and I would have it. I have a whiteboard, and it would be all over my whiteboard, and I'd be like tearing it up. This is so cool. Um, and I'd have like days to analyze these, right? And then it sped up and it was like two or three a week, and it's and I was like, this is cool, this is cool, I love that. Yeah, there's like 50 to 100 a day currently of new research about trisepatide, semaglitide, redish litide, or I can't say the O1, or or foreglipron.

SPEAKER_03 55:10

Oh for glipron. I that one's real hard for me. That's that's that's out now, isn't it? No, that's not out. Yeah, it's coming soon.

SPEAKER_04 55:20

Or for Glaucana. Finde no Fendeho is that long. Can we get simpler names?

SPEAKER_03 55:27

No, I I always wonder like who decided this weird, like freaking taxonomy for these freaking oh my gosh, somebody told me the story behind this, and I know the answer.

SPEAKER_04 55:39

I'm gonna I'm gonna write a substack article about it. I'm gonna do the research and write it on the list. Put it on the list. No, the list just insane, like really, but the whole point being like this GLP one curve is like exponential, right? Like, yeah, I I love it, I really do. And so, like now I'm sorting through research, and like what you get on my Substack or what I talk about is like maybe a percent of what's happening, yeah, because there's just so much, right? And like, so I hope that gives you all peace. Like, listeners who are also like GLP1 patients, and like it gives me peace that the people are investigating it from the qualitative people survey, people experiences to the like cellular, what is happening, what's the mechanism of action, and how does that mechanism affect every single cell and part of your body? Yeah, um, so like people are looking at this, and and that's cool.

SPEAKER_03 56:36

It is cool. I love that's cool. That's crazy.

SPEAKER_00 56:39

I love it.

SPEAKER_03 56:40

I mean, I think it's um like if anything, it's it's nice not to have to like always defend it all the time, you know. But I do think that like I'm I'm happy to see people discussing it more openly now um about their uses of it, you know, the reasons why and stuff like that. I I don't I know you weren't at OAC this time, but I have to tell you, like, it was really cool um when their CEO, it was like the first thing, it was like the first day, not everybody was there yet, and he went up and he was talking, and he is a attractive man and a regular size, you know, smaller body. And he said, Um, this matters to me deeply, and you may not think that. And I'm not I'm not talking about any of us, we're thinking it, thinking that. He goes, but my disease is just in a well-controlled state. He's like, I'm on my seventh medication. Like, you know what I mean? So, like, I think that like it's it's something that we think we can look at people and we understand their health because we see their weight, but like there's just so much more going on, and so I think the more time the more we talk about it, especially considering we are testing this in different ways. Sure, we know it helps obesity, right? Sure, we know it helps type 2 diabetes. What's the next thing it helps with? Right, right.

SPEAKER_04 57:50

And that's that's the thing. Yeah, I think it's also weight is really hard to talk about, it's stigmatized, right? And we we talk about like you know, invisible disabilities, right? Like a lot, like that's a thing. Like, you don't know what somebody's got going on mentally, physically, whatever. Like some things are invisible. And that's like really hard to like be like less judgmental about that to think about like I got I got some judgment when I got on GLP ones. I didn't start for obesity, I wasn't thin by any means, but like my motivation was not obesity, it was not losing weight, it was PCOS, something you can't see or P PMOS. It was just rebranded, yeah, yeah, yeah. Um, but yeah, like you just don't know what folks are going through. So, like be nice. I know.

SPEAKER_03 58:35

Like, I think what a lot of people like, especially like with the PCOS thing that don't understand, is like that's that's usually insulin resistance, right? Which leads to all these things. Like, we just had this really good episode about you should watch if you haven't seen it, um, where we talked about that and and the youth and then how quickly um they become type two diabetic diabetics and start having like organ failure, like in their 20s.

SPEAKER_04 58:56

It's crazy fast.

SPEAKER_03 58:57

Because of how, like, yeah, and and that that the people don't also always think about like the insulin resistance piece of PCOS, and it's just that's really important. So, but another example, like we have to talk about it and not look at somebody's body and decide if they're worthy of care, because frankly, that's not up to you. Now, I want to be really clear. I did used to do that, but then I realized I was being deterred and I stopped. So stop.

SPEAKER_04 59:16

Well, that's what we always get better. And I don't know if this happens to you, Ken, but this happens to me like constantly, uh, especially with family, extended family. They'll be like, hey, Maria, like I saw one of your TikToks. And I have two TikToks. Like, if you want to see a TikTok about flowers and horses, the rising project is a place for you. Um, but I it's very stupid. This is where like my mental health lives. Um, but they come up and they say, you know, I saw your TikTok. And I always think it's about flowers or horses because that's what people want to talk about, right? A lot of times lately in the past few years, it's been about septide, though. They're like, we saw you're on a GLP a lot. And they're like whispering. Also, I don't know if you can tell I'm whispering. And they're like, pull me aside, and like, I'm just like really struggling, and I I didn't know if like you thought it would be okay or whatever. And number one, not a doctor. Um, but number two, like it's helped me a lot. I can tell you what it's done for me and why I've done this. And like it is now a running joke that like my husband's family is like all on GLP ones, they all have issues with like insulin resistance, pre-diabetes, cardiac risk, um, some obesity as well. And and they're all on it now, and they're all like so happy, and they're like, Why did we wait? And I was like, Why were you so ashamed now, too? It is a dinner table discussion when we get together, like we're just like all talking about it, and it's like, what did you see? Rhea, what have you posted about this week? And I heard that my friend whatever was on it, and now we're like supporting each other, and it's like the cutest thing, but like it's been like a disease. It was like fat fun whispering to like the dinner table.

SPEAKER_03 1:00:58

Yeah, I think that's really and I I I think there are more people on than than we realize, and you know, for for some reasons that are good and some reasons that are not, you know, which is another show for another day. Um but I think like they're there, I think like giving just letting everybody understand that like a bare minimum, researching the research, right? AI is your friend sometimes. Just make sure you make sure that it's not just kissing your ass, but it can be your friend in this situation. That's kind of the sources, right? Yeah, like go and look at it, like and see. And then at bare minimum, you research, and then the other thing is you just talk to your doctor about it. You know what I mean? Like, it's there's nothing wrong with investigating, learning, and see if it's something that can help you. There's nothing that should be true with any medicine. Don't you think? Just know all the things, like, know all the things, risk versus reward.

SPEAKER_04 1:01:43

You want to do something for your health or your body, like you're your own advocate, you're the only person driving this body. As much as a doctor is helping and navigating, they're not driving, they don't know. Like, it's up to you to take responsibility for like what's going on in there. And like, I don't read the packets of the pharmacy fully front to back. I don't know anybody who does, but I think it's good to like know. And I I'm not gonna lie, I think AI is pretty great when you're like, hey, AI, this thing I think I want to take. Does it have any interactions? Is there something I should know about it? Like, you know, give me the you know, five bullet points about what I should know about this, and like for sure. That is a quick step to knowing more than just like kind of blindly doing whatever.

SPEAKER_03 1:02:26

Yeah, which I do think in in medicine in general, we've done for a really long time. We've just blindly done whatever. Like the doctor said this, that must be right. If the the this must be right, if they said it was fine, it's probably fine. If they didn't talk about it all, we must be okay. And I think that we're just beyond that now.

SPEAKER_04 1:02:41

Like, we have to like take control, you know, of what and I yeah, I have boomer parents and I love my boomer parents, but like they are very much in the generation of like you don't ask questions, you don't ask questions. That's like just it's rude to ask questions. My mom's but she's yeah, but like as they're navigating health issues as they get older, like it's becoming a real issue because like I'm not at the appointments and they'll just be like, Well, they didn't tell me. And I'm like, Did you ask? And they're like, Why would I ask?

SPEAKER_03 1:03:09

Yeah, yeah, and you're just like just assume everybody. I think that you just sort of assume everybody's got got it, you know? Yeah, and you won't ask, but but I'm not that I'm not I don't live that way anymore. Everything I got questions about everything, and then we end up talking for an hour because all I did was ask questions.

SPEAKER_04 1:03:24

If I don't have questions, I probably am very uncomfortable or I don't like you.

SPEAKER_03 1:03:28

Sure, or I'm out of spoons. If I'm out of spoons, I just tend to just kind of grunt. Mm-hmm. Mm-hmm. That's it. You know, like in a and if you walking, man. Like in a long. Yeah, like I'm gone. I'll talk to you about that. Like, I'm no longer can respond. I'm just like nodding, you know. Yeah, I get it. All right, well, excuse me. Any more uh news or studies you want to highlight on this episode?

SPEAKER_04 1:03:48

I don't know, nothing crazy. I can go on a very long tangent, or we can save it for another episode. Um we got time for a tangent, 15 minutes, Anna. Yeah, so I got to go to a compounding pharmacy where the GLPs are being made, the compounded versions of GLPs, and it was crazy.

SPEAKER_03 1:04:09

Yeah, and because you know what I've been hearing is people be like going over to Lowe's and picking people in trucks and bringing. I think it was Home Depot. I think it was Home Depot. Sorry, Lowe's, sorry, Lowe's, don't see me just my pinnacle. Yeah, and like they're going and picking up people and people just put stuff together. That's what I heard.

SPEAKER_04 1:04:26

Is that I didn't I didn't make it early enough in the morning to hit Home Depot. Um but what I did get to walk into was a bunch of like really cool people, like they were there were like a lot of pharmacists, a lot of things moving, uh, a lot more checks and balances than I realized. Like I know the regulations and like what the FDA says you have to do, and then like because I do a lot of policy work, I know that. But to see how it's being like implemented and then like uh added on to like additional things, like I was like very like happy about this. And mind you, like I have been in the space two and a half years making content. I have worked for telehealth directly, and I've still never been to a compounding pharmacy. I got this one, they called me up, they invited me out, and I was like, heck yeah, I've never seen it. They thought I was nuts as I'm like watching the like file being like stirred in the sterile room in the like sterile container. I'm like, that's traceptide. Like, I think I'm more excited about seeing that than I would be about like seeing any celebrity to be sure. Oh, can I get its autograph? Yeah, no, really. I asked them for a box because I was like, this is so cool! Like, not a box of traceptide, everybody, like a branded box that they custom make, whatever it's cool. Um, but it's just like wild for me to see. Like, you know, the show how it's made, where they're like, This is how we make golf balls or whatever. Yeah, it was like that. Like, you don't think about every single piece. Of compound invits that like have to happen. Like the dry powder to the sterile solution to the vial, to the sealing of the vial, sterile, sterile sealing to the labeling, to the box that it ships in, to the ice packs, to the styrofoam container, to the shipping. Like there are so many pieces with like variables that could change. Like it is truly so cool to see how this is being done. And they were like very transparent. I was like, what's going on? Like, blah, blah. Like, you know, and I was like asking the hard questions. I was like, uh, I always don't like hear about COAs, but everybody, like from lawyers to whatever, say COAs are difficult to acquire, they're difficult to share, certificate of analysis. It's like a purity rating for medications. Um, and he is like, What do you mean, COAs? And he pulls this book that is this thing, yeah. And he's like, This is our current batch of COAs, like for everything that they have in the stereo rooms. And he's like, slaps it on the table in front of me. He says, Go nuts, take pictures, do whatever you want. I've never seen one. Like COAs are like alleged.

SPEAKER_03 1:07:09

Oh, sorry, my kid was trying to come in. We're gonna go. Yeah, I mean, you know, you see them on the internet, but I'm like, Well, what was it? Baby, I'm on the internet. I'm on the internet, don't come in, don't come in the door, don't come in the door. Okay, but he's asking for time because I have screen time. He was just waving his phone. I'm on the internet. All right, hold on. Keep going. So yeah, yeah, so I'm just elusive as you think, huh?

SPEAKER_04 1:07:39

Not as elusive. It's crazy. And uh they exist, they share them pretty readily. He says, like, they give them out all the time. Patients ask for them, they give them. Like, there's no secrets here. Um, what I've experienced when I've asked for them is like you always get the like, yeah, we'll get it to you, and then like it never comes. Yeah, like you know, you just keep doing that. They were like, nah, here we go. And like a lot of places won't let you come in to like where they ship or where they label or where they do storage or anything. He was like, film it all, ask me all the questions, don't hold back. Um, it was just really cool. He was very candid with me and talked about a lot of stuff. We talked about um right before this was right before the peptide meeting, the big elusive FDA peptide meeting that happened last week. And they were all like, you know, like what's gonna happen, Maria? What do you think is gonna happen? And I was like, I don't think you like what I think is gonna happen because they were like, it's gonna be so great, and we're gonna have peptides, and these people are gonna get like more, blah, blah, blah. Spoiler, peptides didn't move after that meeting because that's not how that meeting works. That meeting's more of a listening session. Yeah, uh, but yeah, it was cool. Phil showed me a lot. Love him to death. He works there. Um, the shipping was crazy, how it all has to be recorded, but also secure. Um I don't know. I mean, my mind is just like so blown by like the whole idea of it.

SPEAKER_03 1:08:58

The whole idea of it.

SPEAKER_04 1:08:59

Yeah, it's just it's crazy. And that they don't just make GLP ones, right? Like this is a pharmacy. Pharmacy has like a struggle with sports.

SPEAKER_03 1:09:06

I think like you, you and our friend Sabina, right, like have talked to us about a lot is that there are many different kinds of medicines that are compounded for many different kinds of reasons. So they're they're not only like yeah, you know, it's important to us for GLPs, like they are essential, you know.

SPEAKER_04 1:09:23

So that's where it like goes historically, right? Like every hospital used to have a compounding pharmacy, and we were making our own meds and like the whole apocalypse um kind of idea. And like, but there are plenty of use cases constantly, and they they do these like literally every day. It's like fully staffed to palliative care. Like when you lose your ability to swallow, you do like tinctures under your tongue. Kids are a great reason for a lot of compounds because kids won't eat pills, kids won't do anything that tastes bad. Yeah, he showed me all their flavorings, which also is like super fun. Of like, he's like, What's your favorite flavoring? And I was like, I I don't know. Only thing I remember is like bubblegum amoxicillin. Like that was what I remember from childhood. There apparently now it is like so niche, there's like 30 flavors that you can like come up for kids. It's crazy. That's great. Um, veterinary care is another one. Um, so like we have a lot of meds, and I know this from like being a horse girl, like we have a lot of meds that like we use in people, but there's not like funding for veterinary like medication development. So we use people's stuff. Horses are a thousand pounds, so a lot of times you need a bigger dose. Um, so they do that. Um, there's just like lots of dermatology has been compounding for like years, forever. Dermatologist monoxidil for hair loss, like skin creams for different like hormonal stuff, like HRT. Yeah, I was about to say HRT, perimenopause stuff. Yeah, yeah. It's been happening for years, like compounding pharmacies existed, and that's the other cool thing. I I really enjoy every compounding pharmacy that I've talked to. I've only been to one. Um, they're like family-owned for generations, yeah. And so, like, it is because that was the only pharmacy forever. They no, it was, it was, yeah, and then like CDS Killer Mark video.

SPEAKER_03 1:11:11

It's a great video. Yeah, I'll put it in the thing, put it in the notes.

SPEAKER_04 1:11:15

Yeah, yeah, the video is really cool. I have like lots of video content. I'm still in shock about it. Um, I'm trying to think of what my most shocking thing was. I don't even know. It was just seeing it, honestly, just seeing it all. But like, because we we walked through it all, we talked through it all. They start the tour off, they have this like big, giant, like it's bigger than a door-sized case of like meds that have historically been compounded in this facility. Yeah, and so like this facility has been open for 118 years. They moved the building on a horse and buggy to its current location. Like, that's oh my gosh, yeah, it's insane. That's nuts! Yes, it's crazy. And then they have this case of like historic things that used to be made there, and it's just like mind-blowing. And he's like telling me stories of a few of them because like again, I'm a yaffer, and I'm like, what do you what like what is this? What is that? Like, there's like lead, like lead iodine is in there because we used to like treat people with lead, and then he like jokingly is just like, and then we found out that was pretty bad, so we stopped doing that, and it's just like, but that's like how it worked.

SPEAKER_03 1:12:19

Yeah, that's still like many years ago, people yeah, well, not the not the lead stuff, but then still we're like, oh shit, we shouldn't shouldn't do that anymore.

SPEAKER_04 1:12:29

Yes, yes, well, and then like the so like I'm a flower farmer as a hobby and I love it, and I've been trying to like extract my own like lavender and calendula oil, but then like Phil, the pharmaceutic, this compounding pharmacy, there's like tons of bottles of gin and vodka in here, and he was like, Yeah, we infused stuff into gin and vodka and gave it to folks, and I was like, You mean what I'm doing in my backyard right now? And he's like, That was like kind of what we were doing. You're like a compound pharmacist. That's what I took out of it too. Um and it's just like interesting to think about like they would put different stuff that they found in the environment, like and whatever in these like elixir that like strip the oils away and made them more like accessible, and like that was literally how like we were treating people, and like I don't know, it just like blows my mind. Like, I just always think of logistics and how things work and how things are related, and it's crazy.

SPEAKER_03 1:13:30

Yeah, well, I think this has been some very good tea. What's crazy is we'll post this and then like something crazy will happen and we'll we miss the opportunity because it happened like at the end of the day, but it's cool when we do, we'll have Maria come back. Uh, and sometimes when Sabina can come back, she comes back too and keep us all informed about all the cool fun. So I hope that you loved this episode and had a good time talking with us about things that are in the news, things that are in research, and how we'd like things to possibly be going forward, because I do think that we are at a point in history where we can start as patients having more power and saying what we will and will not accept. But we just gotta all do it together and point at the same thing. That's that's what I think. Now that was that was my end of the day out of spoons explanation. And if you like all this, do all the things with the buttons, and then I'm gonna put the in the notes, we'll put your substack in the notes and your socials in the notes so they can go follow and look at the compound video, it'll be neat so you can see how everything works. And other than that, you got any sign-offs for us? I don't know how to officially sign off.

SPEAKER_04 1:14:36

Yeah, I'm excited. Like, follow the substack, follow the tick tocks, and honestly, comment what you want to hear. I love feedback, like that's the part of the social media that we don't get so much.

SPEAKER_00 1:14:49

Just be nice though.

SPEAKER_04 1:14:50

Just be nice, yeah. Nice, constructive, constructive feedback. Like, say constructive criticism, just just be like, you know, it'll be great. You can do this. Yeah, like hey, Maria, I'd really like to know about the research for uh yes what Yogi Wands does to my skin, whatever. I don't know what it might be. Yes, there's research. Why do we have Olympic space? I don't know, whatever. Whatever you can think of. Oh my god, yes, but tell me, and I love to write articles that I know are gonna land with somebody because I don't do all of this because I'm just like really into like writing long articles or whatever. Okay, which I kind of am, honestly. But it's not the primary goal. The primary goal is to connect with other people and give them useful information. So if I know what the useful information is for you, I'd love to provide that.

SPEAKER_03 1:15:34

Yes, I love that. Well, put it in here and I'll make sure she gets it and uh writes us some stuff. That'll be great, huh? All right. Oh, yeah. We love you guys. We will see you next week. Asta La Pasta. Toodles. Are you interested in understanding GOP1 medications like OSymphic, Wolfie, or Manjaro? Then join us on the Plus Side, cracking the Obesity Code, the groundbreaking podcast helping people change their lives one episode at a time.

SPEAKER_01 1:16:01

The Plus Side Podcast is Disruptor.

SPEAKER_03 1:16:04

We're breaking down barriers, smashing stereotypes, and sharing inspiring stories that leave you feeling enforced and empowered. Join us every week to learn from doctors to a specialist around GLP1 medications like obesity, the Goku Manjaro. We'll provide you with science and facts to validate incredible stories. But that's not all. We'll also bring you the voices of the GLP1 Manjaro TikTok community, real people who face the challenges of obesity related diseases and disorders, and discover the incredible plus sides of GLP1 medications. Our episodes are filled with heartwarming stories, laughter, and moments of triumph. You'll connect with our amazing community members who are reclaiming their health and experiencing their fullest lives. Are you ready to embark on a journey of discovery and empowerment? Tune in to the plus sides, cracking the obesity code, and together we'll change the narrative around obesity in the stigma. Subscribe now on YouTube or your favorite podcast platform and join our incredible community. Let's celebrate the plus sides of life together because every story deserves to be heard. Every life deserves to shine, and everyone deserves access to expert knowledge and medication. The plus side podcast, you're not alone. It's not your fault.

SPEAKER_02 1:17:20

What the fact is for half the site? With the formula for the formula, that's the first one.