The Metabolic Compass™ Podcast
The Metabolic Compass™ Podcast helps you decode your body’s signals and recalibrate your biology using a proven 4-direction framework—Nurture, Energize, Strengthen, and Withdraw. Rooted in cutting-edge science and real-life application, each episode guides you toward lasting health, resilience, and purpose.
The Metabolic Compass™ Podcast
Episode 016 - Butyrate: The Most Underrated Molecule in Human Health
Butyrate might be the most underrated molecule in human health.
In this episode, Brandon explains how butyrate stabilizes signals across the gut–liver axis, mitochondria, and immune tone—why many people don’t feel much from older forms—and how improved bioavailability changes outcomes.
You’ll learn:
• What butyrate does (gut barrier, immune calibration, mitochondrial support, redox balance)
• Endogenous vs. supplemental butyrate—and where each shines
• Practical use cases: cravings, energy stability, mood, sleep architecture, exercise recovery
• Forms & bioavailability: 2024 PK data comparing sodium butyrate, spray‑dried tributyrin, and BIOMEnd® (tributyrin performed ~5× worse than BIOMEnd® in that study; no coated/time‑release butyrate was included)
• How to integrate butyrate into a daily stack without overwhelm
🎯 Take the Drift Quiz: https://www.themetaboliccompass.com/quiz
➡️ Next: Episode 017 — Why Morning Light May Be the Most Powerful Hormone Reset Tool You’re Ignoring