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  Your Genes by Design
Your Genes by Design: practical genetics for women 45+. Weekly 5–10 minute episodes that turn complex science into everyday insight — with articles and helpful freebies to support your journey.
Your Genes by Design
Oxygenation: The Missing Link Between Energy, Glucose, and Genes
Feeling steady energy isn’t luck — it’s the result of how efficiently our cells use oxygen to turn fuel into power. In this episode, we trace the path from breath to mitochondria to blood sugar, showing how oxygenation influences glucose and insulin balance after 45.
What You’ll Learn
- How oxygen use determines whether glucose becomes clean energy or stored fuel
- Why mitochondrial health is the missing link between insulin sensitivity and stamina
- The roles of PPARGC1A, SOD2, and NOS3 in energy production, antioxidant defense, and blood flow
- How estrogen and thyroid changes after 45 affect oxygen delivery and glucose balance
- Simple ways to support oxygenation through breathing, movement, and nutrition
Your Next Step Toward Steadier Energy
 If your energy feels unpredictable — clear one day and flat the next — small shifts can help. Move often, breathe through your nose, focus on nutrients that fuel mitochondria, and protect your sleep window. When oxygen delivery improves, glucose burns cleanly, energy steadies, and recovery feels easier.
The Precision Piece
 If you’ve noticed slower recovery, afternoon fatigue, or brain fog that coffee can’t fix, your genes may reveal why. Variants in PPARGC1A, SOD2, and NOS3 affect how efficiently your cells use oxygen and handle oxidative stress. Understanding those patterns isn’t about perfection — it’s about precision. The more you know how your body is wired, the easier it becomes to build steadier energy and clearer focus — by design.
In this 5-minute episode, we explore how oxygenation influences glucose and insulin balance — and how genes like PPARGC1A, SOD2, and NOS3 shape energy, recovery, and focus after 45.
 💬 Full transcript → 
